GRAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.52985084
2negative T cell selection (GO:0043383)7.29273337
3positive T cell selection (GO:0043368)6.98504553
4regulation of gamma-delta T cell differentiation (GO:0045586)6.71299272
5positive thymic T cell selection (GO:0045059)6.71260237
6negative thymic T cell selection (GO:0045060)6.69309562
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.53446854
8negative regulation of cell killing (GO:0031342)6.53446854
9neutrophil activation involved in immune response (GO:0002283)6.52853668
10T cell selection (GO:0045058)6.19003681
11regulation of gamma-delta T cell activation (GO:0046643)6.17762176
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.16928369
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.16928369
14interferon-gamma production (GO:0032609)6.10103319
15thymic T cell selection (GO:0045061)6.04274331
16response to interleukin-15 (GO:0070672)5.77144643
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.72815634
18antigen processing and presentation of endogenous antigen (GO:0019883)5.66722657
19positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.51897594
20T cell migration (GO:0072678)5.28062423
21cellular response to interleukin-15 (GO:0071350)5.18750357
22thrombin receptor signaling pathway (GO:0070493)5.12274692
23regulation of isotype switching to IgG isotypes (GO:0048302)5.03602461
24regulation of platelet aggregation (GO:0090330)4.93181315
25* T cell receptor signaling pathway (GO:0050852)4.86552553
26leukocyte aggregation (GO:0070486)4.58293888
27activated T cell proliferation (GO:0050798)4.57334774
28leukocyte migration involved in inflammatory response (GO:0002523)4.52887291
29regulation of T cell tolerance induction (GO:0002664)4.48741987
30neutrophil activation (GO:0042119)4.48283300
31regulation of regulatory T cell differentiation (GO:0045589)4.40194735
32positive regulation of interleukin-2 production (GO:0032743)4.37942486
33* antigen receptor-mediated signaling pathway (GO:0050851)4.31062516
34positive regulation of mast cell activation (GO:0033005)4.29537504
35regulation of B cell receptor signaling pathway (GO:0050855)4.28565390
36regulation of interleukin-12 biosynthetic process (GO:0045075)4.26121169
37* T cell costimulation (GO:0031295)4.20924017
38regulation of alpha-beta T cell proliferation (GO:0046640)4.18188337
39* lymphocyte costimulation (GO:0031294)4.13253321
40regulation of interleukin-2 biosynthetic process (GO:0045076)4.03338975
41granulocyte activation (GO:0036230)4.01045576
42megakaryocyte development (GO:0035855)3.98849947
43regulation of platelet activation (GO:0010543)3.96460990
44regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.94117095
45V(D)J recombination (GO:0033151)3.91936484
46positive regulation of isotype switching (GO:0045830)3.90708971
47regulation of T cell receptor signaling pathway (GO:0050856)3.89354172
48regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.88947328
49negative regulation of T cell mediated immunity (GO:0002710)3.82595812
50alpha-beta T cell activation (GO:0046631)3.80894399
51positive regulation of macrophage differentiation (GO:0045651)3.79314782
52platelet aggregation (GO:0070527)3.78114467
53G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.76065601
54tolerance induction (GO:0002507)3.74205660
55leukocyte degranulation (GO:0043299)3.73576300
56alpha-beta T cell differentiation (GO:0046632)3.72467772
57positive regulation of tolerance induction (GO:0002645)3.65977496
58T cell homeostasis (GO:0043029)3.65566429
59T cell differentiation (GO:0030217)3.63416256
60protein neddylation (GO:0045116)3.62440688
61negative regulation of T cell apoptotic process (GO:0070233)3.61880437
62regulation of B cell differentiation (GO:0045577)3.58621178
63B cell receptor signaling pathway (GO:0050853)3.57263778
64positive regulation of alpha-beta T cell proliferation (GO:0046641)3.54444057
65Arp2/3 complex-mediated actin nucleation (GO:0034314)3.52731343
66antigen processing and presentation via MHC class Ib (GO:0002475)3.48749995
67modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.47020865
68positive regulation by organism of defense response of other organism involved in symbiotic interact3.47020865
69modulation by symbiont of host immune response (GO:0052553)3.47020865
70positive regulation by symbiont of host defense response (GO:0052509)3.47020865
71modulation by symbiont of host defense response (GO:0052031)3.47020865
72modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.47020865
73mast cell activation (GO:0045576)3.43323570
74angiogenesis involved in wound healing (GO:0060055)3.41086959
75positive regulation of DNA recombination (GO:0045911)3.40356726
76negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.39945508
77regulation of isotype switching (GO:0045191)3.38710286
78myeloid cell activation involved in immune response (GO:0002275)3.38057056
79lymphocyte homeostasis (GO:0002260)3.36353264
80NIK/NF-kappaB signaling (GO:0038061)3.35997567
81adenosine receptor signaling pathway (GO:0001973)3.33995849
82regulation of tolerance induction (GO:0002643)3.30841125
83regulation of interleukin-2 production (GO:0032663)3.30346236
84negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.28227107
85negative regulation of T-helper cell differentiation (GO:0045623)3.28227107
86natural killer cell activation (GO:0030101)3.26779325
87regulation of mast cell degranulation (GO:0043304)3.26067999
88mast cell degranulation (GO:0043303)3.24787045
89mast cell activation involved in immune response (GO:0002279)3.24787045
90regulation of mast cell activation (GO:0033003)3.23427669
91cellular extravasation (GO:0045123)3.21906903
92positive regulation of immunoglobulin mediated immune response (GO:0002891)3.20239695
93positive regulation of B cell mediated immunity (GO:0002714)3.20239695
94negative regulation of erythrocyte differentiation (GO:0045647)3.20108604
95positive regulation of granulocyte differentiation (GO:0030854)3.18497913
96regulation of response to interferon-gamma (GO:0060330)3.18000983
97positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.17248305
98leukocyte cell-cell adhesion (GO:0007159)3.16704337
99natural killer cell differentiation (GO:0001779)3.16691311
100purinergic nucleotide receptor signaling pathway (GO:0035590)3.16356271
101regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.16282161
102positive regulation of humoral immune response (GO:0002922)3.15814258
103dendritic cell chemotaxis (GO:0002407)3.14524490
104negative regulation of homotypic cell-cell adhesion (GO:0034111)3.12841529
105lipoxygenase pathway (GO:0019372)3.11292590
106negative regulation of thymocyte apoptotic process (GO:0070244)3.11237403
107T cell activation (GO:0042110)3.10984185
108antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.10972940
109microglial cell activation (GO:0001774)3.10347033
110blood coagulation, intrinsic pathway (GO:0007597)3.07939964
111negative regulation of lymphocyte mediated immunity (GO:0002707)3.06263003
112regulation of natural killer cell mediated immunity (GO:0002715)3.05675964
113regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.05675964
114regulation of mast cell activation involved in immune response (GO:0033006)3.05601736
115regulation of type I interferon-mediated signaling pathway (GO:0060338)3.05447973
116T cell proliferation (GO:0042098)3.05424937
117negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.05409104
118homotypic cell-cell adhesion (GO:0034109)3.04929449
119* immune response-activating cell surface receptor signaling pathway (GO:0002429)3.04520355
120detection of other organism (GO:0098543)3.04351001
121platelet formation (GO:0030220)3.04031486
122positive regulation of immunoglobulin production (GO:0002639)3.02492082
123detection of bacterium (GO:0016045)3.01465874
124regulation of homotypic cell-cell adhesion (GO:0034110)3.01308292
125JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.00128188
126positive regulation of endothelial cell differentiation (GO:0045603)2.99467656
127regulation of immunoglobulin mediated immune response (GO:0002889)2.97632118
128dendritic cell migration (GO:0036336)2.96621464
129positive regulation of B cell differentiation (GO:0045579)2.96457547
130regulation of granulocyte differentiation (GO:0030852)2.95939312
131hepatocyte apoptotic process (GO:0097284)2.93732048
132regulation of B cell mediated immunity (GO:0002712)2.93318416
133regulation of immunoglobulin production (GO:0002637)2.89075697
134positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.89045141
135positive regulation of natural killer cell mediated immunity (GO:0002717)2.89045141
136B cell proliferation (GO:0042100)2.89002078
137regulation of MHC class II biosynthetic process (GO:0045346)2.88685708
138negative regulation of T cell receptor signaling pathway (GO:0050860)2.86600607
139lymphocyte migration (GO:0072676)2.84293427
140G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.84206856
141positive regulation of histone deacetylation (GO:0031065)2.84102427
142leukocyte homeostasis (GO:0001776)2.83951405
143actin nucleation (GO:0045010)2.83603024
144negative regulation of leukocyte mediated immunity (GO:0002704)2.81458782
145modulation by virus of host process (GO:0019054)2.80033954
146negative regulation of stress fiber assembly (GO:0051497)2.79796503
147CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.79268605
148T-helper cell differentiation (GO:0042093)2.79268605
149positive regulation of T cell differentiation (GO:0045582)2.78340828
150positive regulation of mast cell degranulation (GO:0043306)2.77424038
151positive regulation of mast cell activation involved in immune response (GO:0033008)2.77424038
152* positive regulation of T cell activation (GO:0050870)2.75583247
153lymphocyte differentiation (GO:0030098)2.74215700
154lymph node development (GO:0048535)2.73156916
155myeloid dendritic cell activation (GO:0001773)2.72874418

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.21169408
2* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.78871184
3E2F7_22180533_ChIP-Seq_HELA_Human4.80761118
4MYC_22102868_ChIP-Seq_BL_Human4.25868501
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.86625230
6RUNX_20019798_ChIP-Seq_JUKART_Human3.70884828
7* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.70738129
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.49344962
9* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.40531284
10* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.27961264
11MYB_26560356_Chip-Seq_TH2_Human3.27769517
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.13855087
13EGR1_19374776_ChIP-ChIP_THP-1_Human3.05376988
14MAF_26560356_Chip-Seq_TH1_Human2.98087418
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.93504616
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.93193013
17UTX_26944678_Chip-Seq_JUKART_Human2.79087712
18VDR_21846776_ChIP-Seq_THP-1_Human2.78053508
19MYB_26560356_Chip-Seq_TH1_Human2.77436318
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.67061995
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.45779791
22KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.35653514
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.30524357
24* TCF7_22412390_ChIP-Seq_EML_Mouse2.28141572
25SCL_19346495_ChIP-Seq_HPC-7_Human2.21134948
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.08698255
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.08317550
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.05168534
29MAF_26560356_Chip-Seq_TH2_Human2.04436228
30IRF8_21731497_ChIP-ChIP_J774_Mouse2.04413181
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04184430
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.01754952
33RUNX1_22412390_ChIP-Seq_EML_Mouse2.01208728
34* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.00537990
35KDM2B_26808549_Chip-Seq_DND41_Human1.99194127
36* GATA3_27048872_Chip-Seq_THYMUS_Human1.94571386
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.93018431
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92222785
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.92202320
40CIITA_25753668_ChIP-Seq_RAJI_Human1.89474520
41VDR_24763502_ChIP-Seq_THP-1_Human1.89424236
42* IRF8_27001747_Chip-Seq_BMDM_Mouse1.87512370
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.87091713
44SPI1_23547873_ChIP-Seq_NB4_Human1.72722699
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.70092747
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.68211769
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.65087743
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63144204
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61837138
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52479623
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46886486
52RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.44455281
53* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.44192925
54* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41688044
55E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37493246
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.35940465
57* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35400945
58KDM2B_26808549_Chip-Seq_JURKAT_Human1.32573495
59* SPI1_23127762_ChIP-Seq_K562_Human1.31398828
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29749770
61GATA1_19941827_ChIP-Seq_MEL86_Mouse1.29448622
62* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28591831
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.22863995
64* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20822614
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.18222430
66BP1_19119308_ChIP-ChIP_Hs578T_Human1.16951137
67PU_27001747_Chip-Seq_BMDM_Mouse1.16359236
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.15877609
69GATA3_26560356_Chip-Seq_TH2_Human1.14119686
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14063618
71ELK4_26923725_Chip-Seq_MESODERM_Mouse1.14058849
72SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13654442
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10358137
74GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10205522
75STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08986021
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08939408
77SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.08572411
78KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.08507774
79CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08467465
80VDR_24787735_ChIP-Seq_THP-1_Human1.06830964
81SPI1_20517297_ChIP-Seq_HL60_Human1.06736899
82NCOR1_26117541_ChIP-Seq_K562_Human1.06501935
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04023547
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01496990
85* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01496837
86GATA1_19941826_ChIP-Seq_K562_Human1.00457708
87PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00003328
88FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.99600786
89PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98853039
90* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.98476891
91FOXP3_21729870_ChIP-Seq_TREG_Human0.97131075
92VDR_23849224_ChIP-Seq_CD4+_Human0.96433954
93ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95929831
94* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90467169
95CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85144706
96RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84338415
97SMRT_27268052_Chip-Seq_Bcells_Human0.84213135
98* GATA2_19941826_ChIP-Seq_K562_Human0.83770612
99KDM5A_27292631_Chip-Seq_BREAST_Human0.83294282
100STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.82852105
101NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.82676967
102BCL6_27268052_Chip-Seq_Bcells_Human0.80343702
103STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.79952389
104HOXB4_20404135_ChIP-ChIP_EML_Mouse0.79516060
105GATA3_26560356_Chip-Seq_TH1_Human0.78987580
106NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.76520452
107TP63_19390658_ChIP-ChIP_HaCaT_Human0.75760701
108CTCF_27219007_Chip-Seq_ERYTHROID_Human0.75020974
109CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75009306
110* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.74767652
111BCOR_27268052_Chip-Seq_Bcells_Human0.74204080
112SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.73312317
113* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72702769
114CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72695604
115* SALL4_22934838_ChIP-ChIP_CD34+_Human0.72623118
116CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.71972906
117GATA1_22025678_ChIP-Seq_K562_Human0.71861809
118ETS1_22383799_ChIP-Seq_G1ME_Mouse0.71537923
119* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.69860666
120DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.69020613
121* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.68818943
122PKCTHETA_26484144_Chip-Seq_BREAST_Human0.68290528
123* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66991280
124KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.66393858

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.42688598
2MP0005671_abnormal_response_to3.99650756
3MP0000685_abnormal_immune_system3.71247918
4MP0001835_abnormal_antigen_presentation3.53542630
5MP0001800_abnormal_humoral_immune3.43635539
6MP0001790_abnormal_immune_system3.35873786
7MP0005387_immune_system_phenotype3.35873786
8MP0008004_abnormal_stomach_pH3.27173384
9* MP0002398_abnormal_bone_marrow2.99968898
10MP0002420_abnormal_adaptive_immunity2.85499372
11MP0001819_abnormal_immune_cell2.81037311
12* MP0000703_abnormal_thymus_morphology2.79639149
13MP0002723_abnormal_immune_serum2.79273520
14MP0005000_abnormal_immune_tolerance2.77352877
15MP0002452_abnormal_antigen_presenting2.72192063
16MP0009333_abnormal_splenocyte_physiolog2.69858090
17MP0002396_abnormal_hematopoietic_system2.67367674
18MP0002166_altered_tumor_susceptibility2.60320881
19* MP0000716_abnormal_immune_system2.52734842
20MP0002722_abnormal_immune_system2.44962499
21MP0001873_stomach_inflammation2.44569975
22MP0002405_respiratory_system_inflammati2.43207266
23MP0003300_gastrointestinal_ulcer2.42590883
24MP0000689_abnormal_spleen_morphology2.38334558
25MP0005025_abnormal_response_to2.23182671
26MP0002006_tumorigenesis2.23121736
27MP0009785_altered_susceptibility_to2.21220699
28MP0010155_abnormal_intestine_physiology2.20618289
29MP0003436_decreased_susceptibility_to2.19900683
30* MP0002429_abnormal_blood_cell2.09893412
31MP0003303_peritoneal_inflammation2.05646569
32MP0003866_abnormal_defecation2.04075672
33MP0004947_skin_inflammation1.96311350
34MP0004808_abnormal_hematopoietic_stem1.91080873
35MP0005083_abnormal_biliary_tract1.90757499
36MP0002419_abnormal_innate_immunity1.80760501
37MP0005464_abnormal_platelet_physiology1.78000962
38MP0006082_CNS_inflammation1.75440241
39MP0002148_abnormal_hypersensitivity_rea1.74808987
40MP0002132_abnormal_respiratory_system1.69438326
41MP0004510_myositis1.67138032
42MP0001845_abnormal_inflammatory_respons1.64990736
43MP0003828_pulmonary_edema1.55779412
44MP0005310_abnormal_salivary_gland1.49105480
45MP0008057_abnormal_DNA_replication1.47304931
46MP0002933_joint_inflammation1.47077415
47MP0001853_heart_inflammation1.45627670
48MP0009278_abnormal_bone_marrow1.41290687
49MP0000490_abnormal_crypts_of1.40119495
50MP0004381_abnormal_hair_follicle1.39026303
51MP0000343_altered_response_to1.38267041
52MP0005397_hematopoietic_system_phenotyp1.37967328
53MP0001545_abnormal_hematopoietic_system1.37967328
54MP0002009_preneoplasia1.33720333
55MP0000465_gastrointestinal_hemorrhage1.33163059
56MP0000858_altered_metastatic_potential1.30404989
57MP0008260_abnormal_autophagy1.27330818
58MP0003724_increased_susceptibility_to1.27042327
59MP0004130_abnormal_muscle_cell1.25516029
60MP0003077_abnormal_cell_cycle1.16496820
61MP0002019_abnormal_tumor_incidence1.15535147
62MP0008961_abnormal_basal_metabolism1.14137433
63MP0005174_abnormal_tail_pigmentation1.12655548
64MP0010094_abnormal_chromosome_stability1.11348419
65MP0003566_abnormal_cell_adhesion1.08212220
66MP0005075_abnormal_melanosome_morpholog1.06546202
67MP0003448_altered_tumor_morphology1.03872715
68MP0000249_abnormal_blood_vessel1.01640188
69MP0004883_abnormal_blood_vessel0.99836385
70MP0005076_abnormal_cell_differentiation0.99188515
71MP0005058_abnormal_lysosome_morphology0.98651838
72MP0003638_abnormal_response/metabolism_0.95780294
73MP0010352_gastrointestinal_tract_polyps0.91869024
74MP0000230_abnormal_systemic_arterial0.91696618
75MP0003111_abnormal_nucleus_morphology0.90320489
76MP0004084_abnormal_cardiac_muscle0.90280927
77MP0003172_abnormal_lysosome_physiology0.88471538
78MP0008469_abnormal_protein_level0.87602617
79MP0003656_abnormal_erythrocyte_physiolo0.84987715
80MP0008874_decreased_physiological_sensi0.84751584
81MP0002998_abnormal_bone_remodeling0.80795259
82MP0008058_abnormal_DNA_repair0.79936639
83MP0000015_abnormal_ear_pigmentation0.79329565
84MP0005167_abnormal_blood-brain_barrier0.79206970
85MP0001533_abnormal_skeleton_physiology0.78319826
86MP0003787_abnormal_imprinting0.77635625
87MP0002138_abnormal_hepatobiliary_system0.75767052
88MP0003693_abnormal_embryo_hatching0.74474781
89MP0008872_abnormal_physiological_respon0.74110035
90MP0002095_abnormal_skin_pigmentation0.73185466
91MP0005084_abnormal_gallbladder_morpholo0.73169930
92MP0004036_abnormal_muscle_relaxation0.71631199
93MP0009642_abnormal_blood_homeostasis0.69134865
94MP0001851_eye_inflammation0.69072559
95MP0005381_digestive/alimentary_phenotyp0.68139354
96MP0010307_abnormal_tumor_latency0.65851720
97MP0003183_abnormal_peptide_metabolism0.63331829
98MP0003879_abnormal_hair_cell0.62764183
99MP0000350_abnormal_cell_proliferation0.62166808
100MP0003045_fibrosis0.61943852
101MP0004185_abnormal_adipocyte_glucose0.60774342
102MP0001765_abnormal_ion_homeostasis0.60666894
103MP0001663_abnormal_digestive_system0.60060304
104MP0008775_abnormal_heart_ventricle0.59826133
105MP0005410_abnormal_fertilization0.59179532
106MP0005451_abnormal_body_composition0.59120274
107MP0008007_abnormal_cellular_replicative0.58731303
108MP0003453_abnormal_keratinocyte_physiol0.57958307
109MP0005023_abnormal_wound_healing0.57280137
110MP0002736_abnormal_nociception_after0.56306814
111MP0003075_altered_response_to0.55729205
112MP0005535_abnormal_body_temperature0.55631681
113MP0009765_abnormal_xenobiotic_induced0.55486430
114MP0010329_abnormal_lipoprotein_level0.55251768
115MP0000313_abnormal_cell_death0.54686132
116MP0009764_decreased_sensitivity_to0.54406913
117MP0002136_abnormal_kidney_physiology0.53891665
118MP0005166_decreased_susceptibility_to0.53503897
119MP0004484_altered_response_of0.53096502
120MP0000477_abnormal_intestine_morphology0.52526824
121MP0005164_abnormal_response_to0.51630179
122MP0000609_abnormal_liver_physiology0.51203552
123MP0003191_abnormal_cellular_cholesterol0.51148652
124MP0003795_abnormal_bone_structure0.46563104
125MP0009763_increased_sensitivity_to0.45333175
126MP0001191_abnormal_skin_condition0.44787075
127MP0004957_abnormal_blastocyst_morpholog0.44487067
128MP0001243_abnormal_dermal_layer0.42252163
129MP0009931_abnormal_skin_appearance0.40490389
130MP0003091_abnormal_cell_migration0.40370187
131MP0005621_abnormal_cell_physiology0.40130912
132MP0008770_decreased_survivor_rate0.38929918
133MP0002083_premature_death0.38329141
134MP0000367_abnormal_coat/_hair0.36704567
135MP0001216_abnormal_epidermal_layer0.36504630

Predicted human phenotypes

RankGene SetZ-score
1Menorrhagia (HP:0000132)7.74996324
2T lymphocytopenia (HP:0005403)7.68517361
3Abnormality of T cell number (HP:0011839)7.32534762
4Purpura (HP:0000979)6.84537462
5Panhypogammaglobulinemia (HP:0003139)5.54401569
6Recurrent viral infections (HP:0004429)5.36563409
7Abnormality of T cells (HP:0002843)5.13188025
8Abnormal delayed hypersensitivity skin test (HP:0002963)4.86575137
9Severe combined immunodeficiency (HP:0004430)4.76298206
10Recurrent fungal infections (HP:0002841)4.66483293
11Abnormality of the fingertips (HP:0001211)4.66324481
12Combined immunodeficiency (HP:0005387)4.60141175
13Impaired platelet aggregation (HP:0003540)4.52923426
14Abnormal platelet function (HP:0011869)4.52923426
15Chronic otitis media (HP:0000389)4.31602353
16IgM deficiency (HP:0002850)4.25406661
17Pustule (HP:0200039)4.23045133
18Recurrent bronchitis (HP:0002837)4.19665687
19Abnormality of B cell number (HP:0010975)4.19516062
20B lymphocytopenia (HP:0010976)4.19516062
21Hyperlipoproteinemia (HP:0010980)4.04347661
22Nasal polyposis (HP:0100582)3.95609389
23Abnormality of macrophages (HP:0004311)3.92385564
24Eosinophilia (HP:0001880)3.91624420
25Thyroiditis (HP:0100646)3.88538766
26Elevated erythrocyte sedimentation rate (HP:0003565)3.85328562
27Stomatitis (HP:0010280)3.80460734
28IgG deficiency (HP:0004315)3.80137759
29Recurrent cutaneous fungal infections (HP:0011370)3.79858721
30Chronic mucocutaneous candidiasis (HP:0002728)3.79858721
31Poikilocytosis (HP:0004447)3.76322236
32Abnormality of eosinophils (HP:0001879)3.56921869
33Agammaglobulinemia (HP:0004432)3.51201128
34Abnormality of the heme biosynthetic pathway (HP:0010472)3.43443097
35Meningitis (HP:0001287)3.41817937
36Granulocytopenia (HP:0001913)3.35499441
37Inflammation of the large intestine (HP:0002037)3.33230817
38Autoimmune thrombocytopenia (HP:0001973)3.32216332
39Verrucae (HP:0200043)3.28348903
40Papilloma (HP:0012740)3.28348903
41Acanthocytosis (HP:0001927)3.27140345
42Gastrointestinal inflammation (HP:0004386)3.24586619
43Myositis (HP:0100614)3.21729015
44Abnormality of the nasal mucosa (HP:0000433)3.15634291
45Lymphopenia (HP:0001888)3.13790069
46Eczematoid dermatitis (HP:0000976)3.06102188
47Abnormality of T cell physiology (HP:0011840)3.03371004
48Abnormality of cells of the lymphoid lineage (HP:0012140)3.01234970
49Leukocytosis (HP:0001974)2.98446462
50Hypoplasia of the thymus (HP:0000778)2.93141944
51Prolonged bleeding time (HP:0003010)2.92914395
52Spontaneous hematomas (HP:0007420)2.91972100
53Chronic diarrhea (HP:0002028)2.86047277
54Conjunctival telangiectasia (HP:0000524)2.82563113
55Recurrent sinusitis (HP:0011108)2.80582440
56Bruising susceptibility (HP:0000978)2.79460015
57Increased IgE level (HP:0003212)2.79267469
58Vasculitis (HP:0002633)2.78374043
59Abnormality of the common coagulation pathway (HP:0010990)2.76029719
60Encephalitis (HP:0002383)2.70442034
61Basal cell carcinoma (HP:0002671)2.68569619
62Lymphoma (HP:0002665)2.66342864
63Joint swelling (HP:0001386)2.65593780
64Mediastinal lymphadenopathy (HP:0100721)2.63348231
65Colitis (HP:0002583)2.59504168
66Chronic sinusitis (HP:0011109)2.58915927
67Dyschromatopsia (HP:0007641)2.57605438
68Abnormal platelet volume (HP:0011876)2.51935469
69IgA deficiency (HP:0002720)2.51780609
70Recurrent abscess formation (HP:0002722)2.51664085
71Abnormality of the vasculature of the conjunctiva (HP:0008054)2.50843016
72Chronic obstructive pulmonary disease (HP:0006510)2.46881066
73Obstructive lung disease (HP:0006536)2.46881066
74Episodic fever (HP:0001954)2.44829265
75Optic neuritis (HP:0100653)2.39320131
76Retrobulbar optic neuritis (HP:0100654)2.39320131
77Recurrent skin infections (HP:0001581)2.35959266
78Hypochromic microcytic anemia (HP:0004840)2.34966208
79Autoimmune hemolytic anemia (HP:0001890)2.34352923
80Bronchitis (HP:0012387)2.30919484
81Cellulitis (HP:0100658)2.30192650
82Polycythemia (HP:0001901)2.29814060
83Epistaxis (HP:0000421)2.28386197
84Abnormal pupillary function (HP:0007686)2.28059489
85Hepatosplenomegaly (HP:0001433)2.26193374
86Abnormality of iron homeostasis (HP:0011031)2.24438658
87Hemoptysis (HP:0002105)2.21894148
88Pulmonary infiltrates (HP:0002113)2.20557312
89Paralysis (HP:0003470)2.17997702
90Increased IgM level (HP:0003496)2.16391688
91Recurrent gram-negative bacterial infections (HP:0005420)2.14847906
92Hypochromic anemia (HP:0001931)2.14327904
93Cheilitis (HP:0100825)2.12547192
94Recurrent otitis media (HP:0000403)2.09836296
95Abnormality of lateral ventricle (HP:0030047)2.08173598
96Increased density of long bones (HP:0006392)2.08008703
97Gastrointestinal stroma tumor (HP:0100723)2.07741892
98Keratoconjunctivitis (HP:0001096)2.05808988
99Increased serum ferritin (HP:0003281)2.05247004
100Thrombocytosis (HP:0001894)2.02782669
101Recurrent bacterial skin infections (HP:0005406)2.00898952
102Gingival bleeding (HP:0000225)2.00559838
103Petechiae (HP:0000967)2.00170826
104Chest pain (HP:0100749)1.99991813
105Emphysema (HP:0002097)1.97736047
106Orchitis (HP:0100796)1.97344514
107Bronchiectasis (HP:0002110)1.95522872
108Gastrointestinal infarctions (HP:0005244)1.94871338
109Urticaria (HP:0001025)1.94755411
110Tinnitus (HP:0000360)1.94712711
111Aplasia/Hypoplasia of the thymus (HP:0010515)1.94356438
112Abnormality of transition element cation homeostasis (HP:0011030)1.93220675
113Hypergammaglobulinemia (HP:0010702)1.92958351
114Acute hepatic failure (HP:0006554)1.90514605
115Anorexia (HP:0002039)1.90470589
116Ureteral stenosis (HP:0000071)1.88772581
117Vertigo (HP:0002321)1.88620003
118Increased mean platelet volume (HP:0011877)1.85204314
119Periodontitis (HP:0000704)1.85114017
120Arterial thrombosis (HP:0004420)1.84973030
121Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.84797577
122Joint hemorrhage (HP:0005261)1.81231584
123Thrombophlebitis (HP:0004418)1.80288979
124Skin ulcer (HP:0200042)1.79562540
125Prominent nose (HP:0000448)1.78952853
126Amaurosis fugax (HP:0100576)1.78709317
127Abnormal hair whorl (HP:0010721)1.78529305
128Keratoconjunctivitis sicca (HP:0001097)1.78472789
129Gingivitis (HP:0000230)1.77925544
130Microcytic anemia (HP:0001935)1.73651863
131Pulmonary embolism (HP:0002204)1.73438995
132Abnormality of the prostate (HP:0008775)1.72066088
133Bicuspid aortic valve (HP:0001647)1.71354546
134Ureteral obstruction (HP:0006000)1.71091902
135Sepsis (HP:0100806)1.71012559
136Seborrheic dermatitis (HP:0001051)1.69862412

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K16.00857259
2TXK4.70916111
3ITK2.93175262
4GRK62.89090394
5STK102.88184578
6JAK32.80616594
7BMX2.77471538
8EEF2K2.59195978
9ZAP702.55080773
10MAP3K102.49767691
11TAOK32.48452949
12FGFR42.39606533
13TYK22.37440626
14EIF2AK12.15704722
15MAP3K141.97085607
16FGFR31.96197172
17IKBKE1.93404444
18CDK121.88635954
19FGR1.82165846
20NLK1.81536816
21JAK11.79330014
22PTK2B1.73796542
23BMPR21.64816595
24SYK1.64317013
25SIK21.62402779
26LCK1.60803567
27MAP3K131.56710757
28BTK1.55022539
29PIK3CG1.51658635
30TEC1.49521438
31MST41.45465610
32PKN21.43253500
33MARK31.42276517
34HCK1.41592753
35CSK1.40878010
36MYLK1.37872566
37PIM11.30798441
38GRK51.30620471
39PRKCH1.25074940
40TNK21.23858809
41PRKCQ1.18963127
42SIK31.17816170
43IKBKB1.16842120
44MAP3K71.16743601
45LRRK21.16632735
46PRPF4B1.13047866
47CLK11.12095068
48BLK1.07746343
49TBK11.03428019
50STK41.00529979
51TRIB30.97101071
52MAP3K30.93023258
53JAK20.92411542
54IRAK40.92348933
55TESK20.92045118
56CAMKK20.91912934
57CHUK0.90528084
58BRD40.89185120
59CDK40.87424706
60TAOK20.83186390
61MAP3K110.80230058
62MELK0.79416581
63MATK0.78659713
64PDGFRB0.77802820
65TGFBR20.77486940
66RPS6KA40.76402020
67SGK30.75653188
68MAP3K10.74317754
69CSF1R0.74254656
70FES0.74133763
71HIPK20.74046550
72MARK20.73089840
73PRKD20.72752018
74LYN0.71714317
75EPHB10.70652496
76PASK0.69278250
77KSR20.68710328
78STK240.68286814
79CDK90.67848558
80PAK10.67604099
81ILK0.67364171
82NEK20.67307159
83FGFR20.66977012
84EPHA30.66594199
85MAPK70.66117268
86FYN0.65364301
87MAP2K30.62474934
88RET0.62359463
89MAP3K50.61937428
90KIT0.60578461
91ALK0.59583157
92TRPM70.59112066
93PDPK10.58470663
94RAF10.57647237
95YES10.56898431
96NME20.56074703
97ADRBK20.52712665
98TYRO30.52666072
99STK30.51399761
100SIK10.51284667
101CDK60.50573104
102PDK10.50093300
103CDC70.49276152
104TAOK10.48374166
105FLT30.48336021
106TTN0.44913316
107RPS6KB20.44824771
108KDR0.44551197
109SGK20.43984651
110MAP3K20.42139216
111MAPK110.41656424
112ERBB20.39417471
113MAPK120.38707240
114IRAK30.38505737
115ACVR1B0.38478172
116PRKD10.37178458
117PTK60.37028552
118NTRK20.34379485
119RPS6KA60.33989753
120CAMKK10.33928662
121ADRBK10.33854915
122ATR0.32915341
123MAPKAPK30.32878990
124INSR0.31055716
125MAPK40.30483982
126CHEK10.30463219
127RPS6KA50.29739065
128IRAK20.27822486
129MAPK30.27495809
130RPS6KC10.27351124
131RPS6KL10.27351124
132ARAF0.26641975
133IRAK10.26333181
134DYRK1B0.25901247
135MAP3K80.25791439
136CDC42BPA0.24986906
137TLK10.24719573
138DMPK0.24395290
139PRKACG0.23637178
140RIPK40.23452367
141MAPKAPK20.22884190
142KSR10.22219372

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.42236096
2* T cell receptor signaling pathway_Homo sapiens_hsa046603.46885614
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.71235110
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.64220039
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.58478207
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.56670403
7Measles_Homo sapiens_hsa051622.56113380
8Antigen processing and presentation_Homo sapiens_hsa046122.33125505
9B cell receptor signaling pathway_Homo sapiens_hsa046622.30955335
10Graft-versus-host disease_Homo sapiens_hsa053322.21983044
11Hematopoietic cell lineage_Homo sapiens_hsa046402.21682491
12Osteoclast differentiation_Homo sapiens_hsa043801.97891885
13SNARE interactions in vesicular transport_Homo sapiens_hsa041301.96111471
14Allograft rejection_Homo sapiens_hsa053301.95165583
15Jak-STAT signaling pathway_Homo sapiens_hsa046301.76630512
16Leishmaniasis_Homo sapiens_hsa051401.75556349
17Acute myeloid leukemia_Homo sapiens_hsa052211.67883122
18Herpes simplex infection_Homo sapiens_hsa051681.65106347
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.54063039
20Chemokine signaling pathway_Homo sapiens_hsa040621.46932905
21Autoimmune thyroid disease_Homo sapiens_hsa053201.46390256
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.44151333
23Hepatitis B_Homo sapiens_hsa051611.43740066
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.41118604
25Chronic myeloid leukemia_Homo sapiens_hsa052201.39629650
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.37944300
27Toxoplasmosis_Homo sapiens_hsa051451.35870280
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.33032760
29Non-homologous end-joining_Homo sapiens_hsa034501.32611611
30Viral myocarditis_Homo sapiens_hsa054161.30934020
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.29879126
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26878364
33Influenza A_Homo sapiens_hsa051641.26739559
34HTLV-I infection_Homo sapiens_hsa051661.22358592
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.22232929
36Pancreatic cancer_Homo sapiens_hsa052121.21902053
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18014844
38Colorectal cancer_Homo sapiens_hsa052101.17651506
39Apoptosis_Homo sapiens_hsa042101.14687930
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10029648
41TNF signaling pathway_Homo sapiens_hsa046681.07725712
42Non-small cell lung cancer_Homo sapiens_hsa052231.05715548
43Epstein-Barr virus infection_Homo sapiens_hsa051690.99931323
44Viral carcinogenesis_Homo sapiens_hsa052030.97338466
45Platelet activation_Homo sapiens_hsa046110.96501057
46Prolactin signaling pathway_Homo sapiens_hsa049170.95287548
47Phagosome_Homo sapiens_hsa041450.92530414
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92255013
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91525150
50Hepatitis C_Homo sapiens_hsa051600.90959962
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90246926
52Arachidonic acid metabolism_Homo sapiens_hsa005900.88273032
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88237696
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87813210
55Endometrial cancer_Homo sapiens_hsa052130.87532433
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.85489482
57Shigellosis_Homo sapiens_hsa051310.85305277
58FoxO signaling pathway_Homo sapiens_hsa040680.84326302
59Base excision repair_Homo sapiens_hsa034100.83730794
60Type I diabetes mellitus_Homo sapiens_hsa049400.83408506
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81336930
62Systemic lupus erythematosus_Homo sapiens_hsa053220.80883833
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80664481
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.79337972
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76698848
66Asthma_Homo sapiens_hsa053100.76388120
67Tuberculosis_Homo sapiens_hsa051520.75892124
68Small cell lung cancer_Homo sapiens_hsa052220.75878478
69Gap junction_Homo sapiens_hsa045400.75328491
70Spliceosome_Homo sapiens_hsa030400.73876231
71Notch signaling pathway_Homo sapiens_hsa043300.73293598
72Malaria_Homo sapiens_hsa051440.72705398
73Lysine degradation_Homo sapiens_hsa003100.72592420
74Prostate cancer_Homo sapiens_hsa052150.72494335
75Nitrogen metabolism_Homo sapiens_hsa009100.70702603
76mRNA surveillance pathway_Homo sapiens_hsa030150.65913033
77DNA replication_Homo sapiens_hsa030300.64974561
78VEGF signaling pathway_Homo sapiens_hsa043700.63350143
79Alcoholism_Homo sapiens_hsa050340.62465086
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62045181
81p53 signaling pathway_Homo sapiens_hsa041150.61244423
82MAPK signaling pathway_Homo sapiens_hsa040100.60522771
83Serotonergic synapse_Homo sapiens_hsa047260.58775205
84African trypanosomiasis_Homo sapiens_hsa051430.58453979
85mTOR signaling pathway_Homo sapiens_hsa041500.58269136
86Legionellosis_Homo sapiens_hsa051340.57990790
87Ribosome_Homo sapiens_hsa030100.57522364
88Rheumatoid arthritis_Homo sapiens_hsa053230.55893089
89Thyroid cancer_Homo sapiens_hsa052160.55781380
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.55567281
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.55549841
92Glycerolipid metabolism_Homo sapiens_hsa005610.55440339
93Glioma_Homo sapiens_hsa052140.54784682
94MicroRNAs in cancer_Homo sapiens_hsa052060.54535914
95Ras signaling pathway_Homo sapiens_hsa040140.54291564
96Collecting duct acid secretion_Homo sapiens_hsa049660.54290855
97Inositol phosphate metabolism_Homo sapiens_hsa005620.52136549
98Pancreatic secretion_Homo sapiens_hsa049720.50122048
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49785976
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49352234
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49292116
102Renal cell carcinoma_Homo sapiens_hsa052110.49255604
103Cell cycle_Homo sapiens_hsa041100.49055118
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48961009
105Olfactory transduction_Homo sapiens_hsa047400.48369048
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48126515
107ECM-receptor interaction_Homo sapiens_hsa045120.47130280
108Long-term depression_Homo sapiens_hsa047300.46957845
109Salmonella infection_Homo sapiens_hsa051320.45819806
110Choline metabolism in cancer_Homo sapiens_hsa052310.45289992
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44639151
112Staphylococcus aureus infection_Homo sapiens_hsa051500.43398394
113Insulin resistance_Homo sapiens_hsa049310.42764116
114RNA degradation_Homo sapiens_hsa030180.40324382
115Fanconi anemia pathway_Homo sapiens_hsa034600.40169450
116Mismatch repair_Homo sapiens_hsa034300.39876222
117Dorso-ventral axis formation_Homo sapiens_hsa043200.39709368
118Endocytosis_Homo sapiens_hsa041440.39657105
119Pathways in cancer_Homo sapiens_hsa052000.39573440
120Pertussis_Homo sapiens_hsa051330.39395774
121Rap1 signaling pathway_Homo sapiens_hsa040150.34224207
122ErbB signaling pathway_Homo sapiens_hsa040120.31778112
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.30684009
124Homologous recombination_Homo sapiens_hsa034400.30625434
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30032720
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.27803822
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27741521

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