GRAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.46644436
2antigen processing and presentation of endogenous antigen (GO:0019883)7.25523055
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.83562645
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.83562645
5positive thymic T cell selection (GO:0045059)6.62131134
6negative T cell selection (GO:0043383)6.35162491
7negative thymic T cell selection (GO:0045060)6.25744231
8regulation of B cell receptor signaling pathway (GO:0050855)6.05216384
9regulation of gamma-delta T cell differentiation (GO:0045586)6.04255704
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.79106201
11positive T cell selection (GO:0043368)5.75847764
12regulation of gamma-delta T cell activation (GO:0046643)5.60018268
13thymic T cell selection (GO:0045061)5.44553972
14response to interleukin-15 (GO:0070672)5.26713111
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.16189543
16negative regulation of cell killing (GO:0031342)5.16189543
17cellular response to interleukin-15 (GO:0071350)5.12349105
18T cell selection (GO:0045058)5.08739436
19positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.00034637
20B cell receptor signaling pathway (GO:0050853)4.85990926
21regulation of isotype switching to IgG isotypes (GO:0048302)4.83807718
22regulation of interleukin-12 biosynthetic process (GO:0045075)4.80136611
23regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.67916136
24leukocyte aggregation (GO:0070486)4.48448691
25T cell migration (GO:0072678)4.46639072
26regulation of T cell tolerance induction (GO:0002664)4.45844168
27immunoglobulin mediated immune response (GO:0016064)4.39442200
28T cell costimulation (GO:0031295)4.37595380
29lymphocyte costimulation (GO:0031294)4.31276858
30positive regulation by symbiont of host defense response (GO:0052509)4.26011443
31modulation by symbiont of host defense response (GO:0052031)4.26011443
32modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.26011443
33modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.26011443
34positive regulation by organism of defense response of other organism involved in symbiotic interact4.26011443
35modulation by symbiont of host immune response (GO:0052553)4.26011443
36detection of bacterium (GO:0016045)4.22884555
37regulation of alpha-beta T cell proliferation (GO:0046640)4.21861530
38antigen receptor-mediated signaling pathway (GO:0050851)4.21532050
39regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.19479226
40interferon-gamma production (GO:0032609)4.12416383
41T cell receptor signaling pathway (GO:0050852)4.11479048
42detection of other organism (GO:0098543)4.11010078
43tolerance induction (GO:0002507)4.08849112
44regulation of B cell differentiation (GO:0045577)4.02588774
45NIK/NF-kappaB signaling (GO:0038061)3.99517254
46positive regulation of interleukin-2 production (GO:0032743)3.96160173
47regulation of interferon-beta biosynthetic process (GO:0045357)3.81501792
48regulation of interleukin-2 biosynthetic process (GO:0045076)3.73848123
49negative regulation of lymphocyte mediated immunity (GO:0002707)3.73007735
50negative regulation of phagocytosis (GO:0050765)3.72311353
51positive regulation of isotype switching (GO:0045830)3.72239976
52cellular response to zinc ion (GO:0071294)3.70629432
53regulation of dendritic cell antigen processing and presentation (GO:0002604)3.68286445
54positive regulation of alpha-beta T cell proliferation (GO:0046641)3.67494388
55regulation of regulatory T cell differentiation (GO:0045589)3.66293236
56macrophage activation involved in immune response (GO:0002281)3.58254495
57B cell mediated immunity (GO:0019724)3.55703781
58negative regulation of leukocyte mediated immunity (GO:0002704)3.54578306
59positive regulation of humoral immune response (GO:0002922)3.54230924
60activated T cell proliferation (GO:0050798)3.53689209
61regulation of T cell receptor signaling pathway (GO:0050856)3.51579563
62positive regulation of tolerance induction (GO:0002645)3.49584820
63negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.49177172
64positive regulation of B cell differentiation (GO:0045579)3.49038481
65neutrophil activation involved in immune response (GO:0002283)3.48888591
66positive regulation of immunoglobulin production (GO:0002639)3.45204750
67interferon-gamma-mediated signaling pathway (GO:0060333)3.38425399
68positive regulation of granulocyte differentiation (GO:0030854)3.38149095
69regulation of antigen processing and presentation (GO:0002577)3.34572952
70response to type I interferon (GO:0034340)3.34560325
71positive regulation of B cell mediated immunity (GO:0002714)3.33621312
72positive regulation of immunoglobulin mediated immune response (GO:0002891)3.33621312
73T cell homeostasis (GO:0043029)3.32485053
74regulation of tolerance induction (GO:0002643)3.31338167
75negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.30596832
76negative regulation of T-helper cell differentiation (GO:0045623)3.29817697
77negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.29817697
78endothelial tube morphogenesis (GO:0061154)3.29754897
79morphogenesis of an endothelium (GO:0003159)3.29754897
80myeloid dendritic cell activation (GO:0001773)3.29420184
81JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.28846377
82regulation of response to interferon-gamma (GO:0060330)3.27405265
83immune response-activating cell surface receptor signaling pathway (GO:0002429)3.27293401
84positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.26218720
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.26012968
86B cell proliferation (GO:0042100)3.25526609
87regulation of type I interferon-mediated signaling pathway (GO:0060338)3.25349541
88type I interferon signaling pathway (GO:0060337)3.24497187
89cellular response to type I interferon (GO:0071357)3.24497187
90negative regulation of erythrocyte differentiation (GO:0045647)3.24105204
91regulation of T cell mediated cytotoxicity (GO:0001914)3.22733531
92respiratory burst (GO:0045730)3.21561185
93mast cell activation (GO:0045576)3.21073851
94positive regulation of DNA recombination (GO:0045911)3.20278504
95myeloid dendritic cell differentiation (GO:0043011)3.20087883
96regulation of isotype switching (GO:0045191)3.19605738
97regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.19525063
98mucosal-associated lymphoid tissue development (GO:0048537)3.19159404
99Peyers patch development (GO:0048541)3.19159404
100regulation of B cell proliferation (GO:0030888)3.18561625
101germinal center formation (GO:0002467)3.18500700
102lymphocyte homeostasis (GO:0002260)3.17656144
103regulation of immunoglobulin production (GO:0002637)3.16561230
104mature B cell differentiation (GO:0002335)3.14853478
105regulation of B cell mediated immunity (GO:0002712)3.14763534
106regulation of immunoglobulin mediated immune response (GO:0002889)3.13129956
107positive regulation of B cell proliferation (GO:0030890)3.11642182
108positive regulation of T cell mediated cytotoxicity (GO:0001916)3.11518941
109T cell proliferation (GO:0042098)3.08771446
110leukocyte cell-cell adhesion (GO:0007159)3.08100259
111positive regulation of antigen processing and presentation (GO:0002579)3.06691841
112detection of external biotic stimulus (GO:0098581)3.06137066
113response to host immune response (GO:0052572)3.05290783
114response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.05290783
115cellular extravasation (GO:0045123)3.04908387
116natural killer cell activation (GO:0030101)3.02817358
117negative regulation of innate immune response (GO:0045824)3.02433556
118regulation of interleukin-2 production (GO:0032663)3.01237055
119positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.01028674
120positive regulation of natural killer cell mediated immunity (GO:0002717)3.01028674
121antigen processing and presentation via MHC class Ib (GO:0002475)3.00055463
122myeloid cell activation involved in immune response (GO:0002275)2.99424168
123regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.98468988
124regulation of natural killer cell mediated immunity (GO:0002715)2.98468988
125positive regulation of B cell activation (GO:0050871)2.96730412
126negative regulation of alpha-beta T cell activation (GO:0046636)2.96701833
127defense response to protozoan (GO:0042832)2.91572480
128negative regulation of interleukin-12 production (GO:0032695)2.90516097
129lymphocyte migration (GO:0072676)2.89346019
130response to muramyl dipeptide (GO:0032495)2.89110767
131regulation of alpha-beta T cell activation (GO:0046634)2.88762021
132lymph node development (GO:0048535)2.88466666
133negative regulation of T cell mediated immunity (GO:0002710)2.88321763
134response to protozoan (GO:0001562)2.87274830
135neutrophil activation (GO:0042119)2.85425322
136regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.84267003
137regulation of B cell activation (GO:0050864)2.79944342
138mononuclear cell proliferation (GO:0032943)2.79749897
139lymphocyte proliferation (GO:0046651)2.78069414
140positive regulation of T cell activation (GO:0050870)2.76776264
141Arp2/3 complex-mediated actin nucleation (GO:0034314)2.76398931

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.54870341
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.83291651
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.72765689
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.62610120
5MYC_22102868_ChIP-Seq_BL_Human3.69769664
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.65347610
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.64254872
8RUNX_20019798_ChIP-Seq_JUKART_Human3.51373807
9* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.45308415
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.37760168
11FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.30056459
12* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.27416502
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.20760128
14MYB_26560356_Chip-Seq_TH2_Human3.04958981
15MAF_26560356_Chip-Seq_TH1_Human2.88508667
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.78963732
17* MYB_26560356_Chip-Seq_TH1_Human2.67423449
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.60285285
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.59327846
20UTX_26944678_Chip-Seq_JUKART_Human2.50745262
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.45490311
22VDR_21846776_ChIP-Seq_THP-1_Human2.42600103
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27111421
24BP1_19119308_ChIP-ChIP_Hs578T_Human2.23645217
25EGR1_19374776_ChIP-ChIP_THP-1_Human2.23164890
26* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.21668116
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.16522342
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.10037929
29E2F7_22180533_ChIP-Seq_HELA_Human2.08662139
30SPI1_23547873_ChIP-Seq_NB4_Human2.03244757
31RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.97588334
32MAF_26560356_Chip-Seq_TH2_Human1.96913931
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.92317648
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.88329509
35TCF7_22412390_ChIP-Seq_EML_Mouse1.87406061
36GATA3_27048872_Chip-Seq_THYMUS_Human1.86793908
37SCL_19346495_ChIP-Seq_HPC-7_Human1.85645009
38VDR_24763502_ChIP-Seq_THP-1_Human1.84171438
39* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.78968221
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.77271205
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70738173
42* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62427648
43* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61542915
44SPI1_23127762_ChIP-Seq_K562_Human1.61010094
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60431528
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59601417
47* KDM2B_26808549_Chip-Seq_DND41_Human1.53889562
48* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48585740
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.47703843
50KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46723880
51GATA2_22383799_ChIP-Seq_G1ME_Mouse1.38521865
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.36677600
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35856182
54BCL6_27268052_Chip-Seq_Bcells_Human1.34191931
55PU_27001747_Chip-Seq_BMDM_Mouse1.32883352
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30768605
57PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22995948
58GATA3_26560356_Chip-Seq_TH2_Human1.22704517
59ELF1_20517297_ChIP-Seq_JURKAT_Human1.21727355
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20350881
61BCOR_27268052_Chip-Seq_Bcells_Human1.19767180
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19524835
63VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14349107
64RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.14225002
65CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13925645
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11957546
67* CIITA_25753668_ChIP-Seq_RAJI_Human1.10891695
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07494723
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06919871
70* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06904178
71CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06751323
72GATA1_22025678_ChIP-Seq_K562_Human1.06170677
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02108025
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99035190
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98082777
76GATA2_21666600_ChIP-Seq_HMVEC_Human0.97412082
77NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96990347
78KDM2B_26808549_Chip-Seq_JURKAT_Human0.96657679
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95875052
80P300_27268052_Chip-Seq_Bcells_Human0.95114567
81CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94338435
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93840710
83CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92208763
84GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90987450
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89823467
86SPI1_20517297_ChIP-Seq_HL60_Human0.88977997
87* P68_20966046_ChIP-Seq_HELA_Human0.87980765
88STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86911978
89VDR_24787735_ChIP-Seq_THP-1_Human0.85651772
90GATA1_19941827_ChIP-Seq_MEL_Mouse0.84578827
91SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.83751471
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83292142
93CTCF_21964334_ChIP-Seq_BJAB-B_Human0.82353117
94CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81973663
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81644418
96SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81374857
97ERG_20887958_ChIP-Seq_HPC-7_Mouse0.79385393
98NCOR1_26117541_ChIP-Seq_K562_Human0.79045592
99PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78382889
100HOXB4_20404135_ChIP-ChIP_EML_Mouse0.78039514
101FOXP3_21729870_ChIP-Seq_TREG_Human0.77441242
102VDR_23849224_ChIP-Seq_CD4+_Human0.76493918
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74521185
104DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74473597
105LXR_22292898_ChIP-Seq_THP-1_Human0.74279161
106PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.72092133
107EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.71775051
108SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.71253296
109FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71021416
110IKZF1_21737484_ChIP-ChIP_HCT116_Human0.70315771
111GATA1_19941826_ChIP-Seq_K562_Human0.70011470
112RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67425109
113Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.67066863

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.56339886
2MP0003763_abnormal_thymus_physiology4.18471735
3MP0005671_abnormal_response_to4.07700131
4MP0000685_abnormal_immune_system3.76752745
5MP0005387_immune_system_phenotype3.74672534
6MP0001790_abnormal_immune_system3.74672534
7MP0001800_abnormal_humoral_immune3.70901592
8MP0003303_peritoneal_inflammation3.07167183
9MP0005000_abnormal_immune_tolerance3.02284461
10MP0002452_abnormal_antigen_presenting3.00056347
11MP0002723_abnormal_immune_serum2.91325064
12* MP0002420_abnormal_adaptive_immunity2.86189547
13* MP0001819_abnormal_immune_cell2.81666958
14MP0009785_altered_susceptibility_to2.79340724
15MP0002398_abnormal_bone_marrow2.64690462
16MP0002166_altered_tumor_susceptibility2.57876134
17MP0005025_abnormal_response_to2.48204184
18MP0003300_gastrointestinal_ulcer2.42995836
19MP0000716_abnormal_immune_system2.41584735
20MP0001873_stomach_inflammation2.39449058
21MP0002405_respiratory_system_inflammati2.36291220
22MP0003436_decreased_susceptibility_to2.31871526
23MP0002148_abnormal_hypersensitivity_rea2.28531222
24MP0003724_increased_susceptibility_to2.25155629
25MP0009333_abnormal_splenocyte_physiolog2.22214829
26MP0001853_heart_inflammation2.21969828
27MP0004510_myositis2.21621088
28MP0006082_CNS_inflammation2.17209901
29MP0000689_abnormal_spleen_morphology2.16154587
30MP0002722_abnormal_immune_system2.08848624
31MP0002419_abnormal_innate_immunity2.08164594
32MP0010155_abnormal_intestine_physiology2.03724448
33MP0000703_abnormal_thymus_morphology1.99425908
34MP0002429_abnormal_blood_cell1.98351058
35MP0002006_tumorigenesis1.95489256
36MP0002396_abnormal_hematopoietic_system1.93497012
37MP0001845_abnormal_inflammatory_respons1.72719833
38MP0003866_abnormal_defecation1.69313937
39MP0001879_abnormal_lymphatic_vessel1.68771879
40MP0004947_skin_inflammation1.63835498
41MP0003191_abnormal_cellular_cholesterol1.56919171
42MP0005464_abnormal_platelet_physiology1.56727889
43MP0002138_abnormal_hepatobiliary_system1.56470711
44MP0002933_joint_inflammation1.54269370
45MP0000465_gastrointestinal_hemorrhage1.44840998
46MP0005310_abnormal_salivary_gland1.43309365
47MP0004808_abnormal_hematopoietic_stem1.36981902
48MP0003172_abnormal_lysosome_physiology1.22447896
49MP0003045_fibrosis1.18049037
50MP0001533_abnormal_skeleton_physiology1.16630902
51MP0008260_abnormal_autophagy1.15560301
52MP0003828_pulmonary_edema1.14841277
53MP0010368_abnormal_lymphatic_system1.14317999
54MP0008469_abnormal_protein_level1.12085886
55MP0003448_altered_tumor_morphology1.05521765
56MP0001851_eye_inflammation1.01923168
57MP0001348_abnormal_lacrimal_gland1.00872537
58MP0000858_altered_metastatic_potential0.98671380
59MP0001545_abnormal_hematopoietic_system0.91553238
60MP0005397_hematopoietic_system_phenotyp0.91553238
61MP0006054_spinal_hemorrhage0.91509233
62MP0008057_abnormal_DNA_replication0.91281056
63MP0002132_abnormal_respiratory_system0.87130677
64MP0000249_abnormal_blood_vessel0.86959647
65MP0009278_abnormal_bone_marrow0.85280047
66MP0004883_abnormal_blood_vessel0.84691651
67MP0009764_decreased_sensitivity_to0.84349214
68MP0003091_abnormal_cell_migration0.81950276
69MP0002019_abnormal_tumor_incidence0.80546877
70MP0005058_abnormal_lysosome_morphology0.79250970
71MP0002998_abnormal_bone_remodeling0.79075642
72MP0000767_abnormal_smooth_muscle0.75375787
73MP0005167_abnormal_blood-brain_barrier0.72839394
74MP0005023_abnormal_wound_healing0.72833708
75MP0002136_abnormal_kidney_physiology0.72236972
76MP0000490_abnormal_crypts_of0.72179027
77MP0002254_reproductive_system_inflammat0.71474946
78MP0003806_abnormal_nucleotide_metabolis0.71283045
79MP0004381_abnormal_hair_follicle0.70610365
80MP0003075_altered_response_to0.68875198
81MP0001663_abnormal_digestive_system0.68210870
82MP0009840_abnormal_foam_cell0.68000781
83MP0009763_increased_sensitivity_to0.66344727
84MP0003279_aneurysm0.59859804
85MP0010352_gastrointestinal_tract_polyps0.59558528
86MP0005075_abnormal_melanosome_morpholog0.57931568
87MP0001986_abnormal_taste_sensitivity0.57925504
88MP0005645_abnormal_hypothalamus_physiol0.57379063
89MP0008874_decreased_physiological_sensi0.56710516
90MP0000015_abnormal_ear_pigmentation0.56281583
91MP0005390_skeleton_phenotype0.55230494
92MP0003690_abnormal_glial_cell0.55218820
93MP0008004_abnormal_stomach_pH0.53668324
94MP0003453_abnormal_keratinocyte_physiol0.53013193
95MP0003252_abnormal_bile_duct0.52511148
96MP0008961_abnormal_basal_metabolism0.52316535
97MP0002693_abnormal_pancreas_physiology0.51856252
98MP0000343_altered_response_to0.49787846
99MP0002277_abnormal_respiratory_mucosa0.48682935
100MP0003795_abnormal_bone_structure0.48215563
101MP0002009_preneoplasia0.47587019
102MP0000609_abnormal_liver_physiology0.46860743
103MP0005174_abnormal_tail_pigmentation0.46717265
104MP0003183_abnormal_peptide_metabolism0.45782782
105MP0000313_abnormal_cell_death0.45779385
106MP0005166_decreased_susceptibility_to0.45308195
107MP0005164_abnormal_response_to0.44374525
108MP0003077_abnormal_cell_cycle0.44022992
109MP0001191_abnormal_skin_condition0.43789029
110MP0005360_urolithiasis0.43327314
111MP0002928_abnormal_bile_duct0.43036944
112MP0001915_intracranial_hemorrhage0.42608346
113MP0003566_abnormal_cell_adhesion0.42551124
114MP0005381_digestive/alimentary_phenotyp0.41872359
115MP0005451_abnormal_body_composition0.41303851
116MP0002653_abnormal_ependyma_morphology0.41102979
117MP0004782_abnormal_surfactant_physiolog0.40379266
118MP0009765_abnormal_xenobiotic_induced0.40214365
119MP0002332_abnormal_exercise_endurance0.40054777
120MP0000604_amyloidosis0.39700603
121MP0005076_abnormal_cell_differentiation0.39587392

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bronchitis (HP:0002837)5.78392118
2T lymphocytopenia (HP:0005403)5.45846233
3Agammaglobulinemia (HP:0004432)5.42708303
4Abnormality of T cell number (HP:0011839)5.37535053
5Chronic otitis media (HP:0000389)4.78004895
6Panhypogammaglobulinemia (HP:0003139)4.74985563
7Recurrent viral infections (HP:0004429)4.62974869
8IgM deficiency (HP:0002850)4.61423729
9Eczematoid dermatitis (HP:0000976)4.58893884
10Recurrent fungal infections (HP:0002841)4.46394666
11Colitis (HP:0002583)4.42660686
12Abnormal delayed hypersensitivity skin test (HP:0002963)4.42191415
13Abnormality of T cells (HP:0002843)4.41212336
14Inflammation of the large intestine (HP:0002037)4.30516641
15Gastrointestinal stroma tumor (HP:0100723)4.26444732
16Recurrent cutaneous fungal infections (HP:0011370)4.20314424
17Chronic mucocutaneous candidiasis (HP:0002728)4.20314424
18Gastrointestinal inflammation (HP:0004386)4.10789814
19Recurrent sinusitis (HP:0011108)4.10593778
20Elevated erythrocyte sedimentation rate (HP:0003565)4.10578074
21Abnormality of the nasal mucosa (HP:0000433)4.09110119
22Stomatitis (HP:0010280)4.04736235
23Lymphopenia (HP:0001888)4.04125870
24Recurrent abscess formation (HP:0002722)3.99560394
25Spontaneous hematomas (HP:0007420)3.96977718
26Nasal polyposis (HP:0100582)3.92434708
27Severe combined immunodeficiency (HP:0004430)3.91942135
28Abnormality of cells of the lymphoid lineage (HP:0012140)3.90494119
29Meningitis (HP:0001287)3.78313686
30Abnormality of B cell number (HP:0010975)3.78208406
31B lymphocytopenia (HP:0010976)3.78208406
32Combined immunodeficiency (HP:0005387)3.75120741
33IgG deficiency (HP:0004315)3.73732331
34Chronic sinusitis (HP:0011109)3.64353758
35Vasculitis (HP:0002633)3.62300179
36Chronic diarrhea (HP:0002028)3.51621508
37IgA deficiency (HP:0002720)3.46692580
38Bronchitis (HP:0012387)3.40453900
39Cellulitis (HP:0100658)3.40297200
40Abnormality of T cell physiology (HP:0011840)3.38148839
41Recurrent bacterial skin infections (HP:0005406)3.35977853
42Verrucae (HP:0200043)3.31878199
43Papilloma (HP:0012740)3.31878199
44Thyroiditis (HP:0100646)3.30717749
45Mediastinal lymphadenopathy (HP:0100721)3.26260914
46Emphysema (HP:0002097)3.25745244
47Recurrent skin infections (HP:0001581)3.18130233
48Pulmonary infiltrates (HP:0002113)3.14701281
49Pustule (HP:0200039)3.14471987
50Myositis (HP:0100614)3.11087871
51Thrombocytosis (HP:0001894)2.96289677
52Abnormality of the fingertips (HP:0001211)2.94940535
53Eosinophilia (HP:0001880)2.94202567
54Autoimmune thrombocytopenia (HP:0001973)2.93245644
55Urticaria (HP:0001025)2.91742858
56Obstructive lung disease (HP:0006536)2.91651766
57Chronic obstructive pulmonary disease (HP:0006510)2.91651766
58Abnormality of eosinophils (HP:0001879)2.86569606
59Hematochezia (HP:0002573)2.82700933
60Autoimmune hemolytic anemia (HP:0001890)2.67987015
61Increased IgE level (HP:0003212)2.67865883
62Leukocytosis (HP:0001974)2.64380045
63Increased IgM level (HP:0003496)2.59666705
64Lymphoma (HP:0002665)2.58148579
65Interstitial pulmonary disease (HP:0006530)2.55794316
66Granulocytopenia (HP:0001913)2.55712433
67Hemoptysis (HP:0002105)2.52685266
68Encephalitis (HP:0002383)2.50791387
69Osteomyelitis (HP:0002754)2.50438543
70Restrictive lung disease (HP:0002091)2.47253943
71Keratoconjunctivitis sicca (HP:0001097)2.45974810
72Gastrointestinal infarctions (HP:0005244)2.44288105
73Abnormality of the prostate (HP:0008775)2.43760895
74Recurrent otitis media (HP:0000403)2.43168357
75Recurrent pneumonia (HP:0006532)2.40999952
76Recurrent lower respiratory tract infections (HP:0002783)2.40681040
77Joint swelling (HP:0001386)2.40042429
78Hypochromic anemia (HP:0001931)2.39315943
79Petechiae (HP:0000967)2.29368539
80Acute hepatic failure (HP:0006554)2.28330697
81Keratoconjunctivitis (HP:0001096)2.28073947
82Arterial thrombosis (HP:0004420)2.26637351
83Chest pain (HP:0100749)2.26082011
84Hypergammaglobulinemia (HP:0010702)2.24912665
85Skin ulcer (HP:0200042)2.23921589
86Abnormality of the pleura (HP:0002103)2.22382338
87Optic neuritis (HP:0100653)2.20464045
88Retrobulbar optic neuritis (HP:0100654)2.20464045
89Sepsis (HP:0100806)2.20273881
90Gingival bleeding (HP:0000225)2.14427506
91Acrocyanosis (HP:0001063)2.13776500
92Hypochromic microcytic anemia (HP:0004840)2.12831365
93Aplasia/Hypoplasia of the thymus (HP:0010515)2.09884276
94Hepatitis (HP:0012115)2.09604515
95Polycythemia (HP:0001901)2.08968861
96Recurrent gram-negative bacterial infections (HP:0005420)2.08701565
97Hypertensive crisis (HP:0100735)2.08474604
98Pulmonary embolism (HP:0002204)2.07087687
99Xerostomia (HP:0000217)2.07052991
100Leukopenia (HP:0001882)2.04656943
101Arthralgia (HP:0002829)2.04496562
102Orchitis (HP:0100796)2.02978777
103Epistaxis (HP:0000421)2.02354108
104Microcytic anemia (HP:0001935)2.02193450
105Fatigue (HP:0012378)2.01460913
106Abnormality of macrophages (HP:0004311)1.99407460
107Gingivitis (HP:0000230)1.99149624
108Purpura (HP:0000979)1.98354686
109Viral hepatitis (HP:0006562)1.97683132
110Hypoplasia of the thymus (HP:0000778)1.96325227
111Reduced subcutaneous adipose tissue (HP:0003758)1.96125303
112Papilledema (HP:0001085)1.94708943
113Skin rash (HP:0000988)1.93260250
114Basal cell carcinoma (HP:0002671)1.92012405
115Prolonged bleeding time (HP:0003010)1.91655054

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K16.31244208
2TXK3.95476473
3MAP3K142.97940956
4JAK32.81367297
5TYK22.73627751
6KDR2.62109101
7PRPF4B2.61061764
8ITK2.58275507
9ZAP702.57530098
10STK102.54014160
11BLK2.34288971
12FGFR42.29254397
13IKBKE2.18510662
14JAK12.15334291
15TGFBR22.13244549
16GRK62.08930815
17TIE12.05215983
18TEC2.01252100
19CSK1.92503151
20SYK1.92071982
21TBK11.88518380
22BTK1.87936958
23MST41.84763497
24TAOK31.80530330
25MAP3K101.68745086
26IRAK41.64763235
27LCK1.60023151
28LRRK21.55571703
29CSF1R1.54927905
30NLK1.54884908
31IKBKB1.53020351
32FGFR31.52671443
33MAP3K131.47904233
34SMG11.42665697
35HCK1.40100913
36KIT1.30465321
37MARK31.19171875
38ERN11.16542637
39CLK11.15401366
40LYN1.15113726
41EPHB11.15080175
42CHUK1.11110185
43SIK31.10944475
44PRKCQ1.10118412
45SIK21.09327837
46FES1.07616383
47PASK1.07185084
48IRAK31.06287158
49PRKCH1.05448627
50EEF2K1.01227553
51TGFBR10.98792793
52GRK10.97376667
53RPS6KA40.92952320
54MAP2K30.88562425
55CDK120.87868051
56MAP3K10.84699100
57RIPK40.80783622
58PIM10.79505807
59JAK20.78747340
60EPHA30.78653046
61CDK190.78307125
62NME20.77858335
63BMPR20.72575528
64CAMKK10.68494461
65SCYL20.68038338
66TNK20.62474649
67CAMKK20.62328305
68NEK90.59026898
69INSR0.56510368
70PTK60.56049499
71TAOK20.54509524
72PKN20.50854509
73MAPK120.49472424
74MAP3K70.49107860
75MAP2K20.45973273
76MAPK70.45489946
77PDPK10.44220077
78PDK10.43140715
79ALK0.42286388
80TRIB30.42152830
81CDC42BPA0.42037227
82CDK40.41587519
83ABL10.41172451
84CDK90.41164196
85IRAK10.40919683
86FYN0.39300630
87MATK0.39010634
88DYRK1B0.38274602
89NUAK10.38176326
90PIK3CG0.37366250
91EGFR0.36393580
92MAP3K30.36390869
93HIPK20.36055357
94PRKD20.35501460
95KSR20.34661412
96PTK2B0.34356639
97IGF1R0.34183089
98TSSK60.32197840
99STK40.32153438
100BCKDK0.31952341
101MAP3K80.31538876
102MAPKAPK20.30370105
103YES10.30293814
104SIK10.29947919
105RPS6KL10.29530292
106RPS6KC10.29530292
107TESK20.29087640
108MELK0.28027099
109PDGFRB0.27266977
110PRKCD0.25184269
111BRD40.23865066
112RPS6KA60.23559317
113MAP3K110.22561713
114PRKD10.21344176
115FGR0.20605803
116GRK70.20066162
117DMPK0.19999147
118MARK20.19916059
119MAP3K50.19666823
120TTN0.19605719
121MAPK40.19342469
122MAPK30.19336507
123MAPK110.18804214
124TAOK10.18373439
125SRC0.17476943
126PKN10.15021226

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.71542856
2NF-kappa B signaling pathway_Homo sapiens_hsa040643.08143051
3B cell receptor signaling pathway_Homo sapiens_hsa046623.04402368
4T cell receptor signaling pathway_Homo sapiens_hsa046603.00657720
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.99854552
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.67379457
7Antigen processing and presentation_Homo sapiens_hsa046122.61838206
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.61029380
9Measles_Homo sapiens_hsa051622.55055058
10Hematopoietic cell lineage_Homo sapiens_hsa046402.42841306
11Allograft rejection_Homo sapiens_hsa053302.37098040
12Graft-versus-host disease_Homo sapiens_hsa053322.32880899
13Leishmaniasis_Homo sapiens_hsa051402.29509704
14Osteoclast differentiation_Homo sapiens_hsa043802.25965362
15Viral myocarditis_Homo sapiens_hsa054161.84157376
16Autoimmune thyroid disease_Homo sapiens_hsa053201.69569125
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.68034572
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.66433136
19Herpes simplex infection_Homo sapiens_hsa051681.66071986
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.54265556
21Leukocyte transendothelial migration_Homo sapiens_hsa046701.52487924
22Toxoplasmosis_Homo sapiens_hsa051451.52307248
23Chemokine signaling pathway_Homo sapiens_hsa040621.49818287
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45667763
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41507724
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36735094
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35819505
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.33619156
29Systemic lupus erythematosus_Homo sapiens_hsa053221.27386559
30Malaria_Homo sapiens_hsa051441.27113329
31Influenza A_Homo sapiens_hsa051641.27100491
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25935232
33TNF signaling pathway_Homo sapiens_hsa046681.22825845
34Shigellosis_Homo sapiens_hsa051311.22022950
35Hepatitis B_Homo sapiens_hsa051611.20325555
36Asthma_Homo sapiens_hsa053101.19871158
37Tuberculosis_Homo sapiens_hsa051521.14702066
38Apoptosis_Homo sapiens_hsa042101.14053096
39Acute myeloid leukemia_Homo sapiens_hsa052211.12777229
40HTLV-I infection_Homo sapiens_hsa051661.05668534
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03849351
42Staphylococcus aureus infection_Homo sapiens_hsa051501.03558413
43Legionellosis_Homo sapiens_hsa051341.02889088
44Epstein-Barr virus infection_Homo sapiens_hsa051691.00192966
45Type I diabetes mellitus_Homo sapiens_hsa049400.99626118
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99112827
47Ribosome_Homo sapiens_hsa030100.97888244
48Pertussis_Homo sapiens_hsa051330.94240555
49Platelet activation_Homo sapiens_hsa046110.92049691
50Pancreatic cancer_Homo sapiens_hsa052120.91649039
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90467188
52Hepatitis C_Homo sapiens_hsa051600.86968857
53Chronic myeloid leukemia_Homo sapiens_hsa052200.84971047
54Phagosome_Homo sapiens_hsa041450.83986512
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83748575
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81243439
57African trypanosomiasis_Homo sapiens_hsa051430.78881198
58Viral carcinogenesis_Homo sapiens_hsa052030.76803164
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75801995
60Salmonella infection_Homo sapiens_hsa051320.75738196
61VEGF signaling pathway_Homo sapiens_hsa043700.71318898
62Prolactin signaling pathway_Homo sapiens_hsa049170.70230533
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70117195
64Small cell lung cancer_Homo sapiens_hsa052220.68628531
65Rheumatoid arthritis_Homo sapiens_hsa053230.62495800
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.59721793
67Notch signaling pathway_Homo sapiens_hsa043300.55036432
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54628448
69Other glycan degradation_Homo sapiens_hsa005110.54620258
70Colorectal cancer_Homo sapiens_hsa052100.54438744
71MAPK signaling pathway_Homo sapiens_hsa040100.51979353
72Base excision repair_Homo sapiens_hsa034100.51928112
73Endocytosis_Homo sapiens_hsa041440.51793112
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46029582
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45101924
76Rap1 signaling pathway_Homo sapiens_hsa040150.42688971
77p53 signaling pathway_Homo sapiens_hsa041150.41383437
78Non-small cell lung cancer_Homo sapiens_hsa052230.41367026
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41151491
80Adherens junction_Homo sapiens_hsa045200.40870942
81Non-homologous end-joining_Homo sapiens_hsa034500.40110949
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.39858757
83Spliceosome_Homo sapiens_hsa030400.39712946
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.38046595
85HIF-1 signaling pathway_Homo sapiens_hsa040660.37986026
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.37883662
87FoxO signaling pathway_Homo sapiens_hsa040680.36810517
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34867540
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34739704
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34118473
91Prostate cancer_Homo sapiens_hsa052150.34097011
92Insulin resistance_Homo sapiens_hsa049310.33543877
93Renal cell carcinoma_Homo sapiens_hsa052110.32749879
94Alcoholism_Homo sapiens_hsa050340.32337888
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.31894692
96Focal adhesion_Homo sapiens_hsa045100.31072573
97Choline metabolism in cancer_Homo sapiens_hsa052310.30884901
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30304634
99Lysosome_Homo sapiens_hsa041420.29233657
100Pathways in cancer_Homo sapiens_hsa052000.28971181
101Proteoglycans in cancer_Homo sapiens_hsa052050.28458795
102MicroRNAs in cancer_Homo sapiens_hsa052060.27079826
103mTOR signaling pathway_Homo sapiens_hsa041500.24205076
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24109905
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.22334229
106Endometrial cancer_Homo sapiens_hsa052130.21970798
107Ras signaling pathway_Homo sapiens_hsa040140.21344505
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.19934092
109Inositol phosphate metabolism_Homo sapiens_hsa005620.19499886
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.18809884
111RNA degradation_Homo sapiens_hsa030180.18049129
112DNA replication_Homo sapiens_hsa030300.17753583
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17750271
114ABC transporters_Homo sapiens_hsa020100.17735320
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16312588
116Mismatch repair_Homo sapiens_hsa034300.15886217
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.15537191
118GnRH signaling pathway_Homo sapiens_hsa049120.14679453
119Regulation of autophagy_Homo sapiens_hsa041400.13055946

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