GRAMD1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)7.70726294
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.70726294
3positive regulation of gamma-delta T cell activation (GO:0046645)7.18667173
4positive thymic T cell selection (GO:0045059)5.88433350
5regulation of gamma-delta T cell differentiation (GO:0045586)5.78328094
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.67834814
7negative T cell selection (GO:0043383)5.61983503
8negative thymic T cell selection (GO:0045060)5.56639128
9regulation of gamma-delta T cell activation (GO:0046643)5.53235720
10positive T cell selection (GO:0043368)5.31881449
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.20722755
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.20722755
13response to interleukin-15 (GO:0070672)5.16479679
14thymic T cell selection (GO:0045061)4.97110649
15response to peptidoglycan (GO:0032494)4.82016216
16cellular response to interleukin-15 (GO:0071350)4.80245408
17T cell selection (GO:0045058)4.75155242
18regulation of isotype switching to IgG isotypes (GO:0048302)4.65166997
19regulation of vitamin D biosynthetic process (GO:0060556)4.53955550
20antigen processing and presentation of endogenous antigen (GO:0019883)4.47658369
21regulation of T-helper 1 cell differentiation (GO:0045625)4.34357710
22regulation of B cell receptor signaling pathway (GO:0050855)4.33555380
23lipopolysaccharide-mediated signaling pathway (GO:0031663)4.22883967
24T cell migration (GO:0072678)4.20455903
25T cell receptor signaling pathway (GO:0050852)4.19834630
26antigen processing and presentation via MHC class Ib (GO:0002475)4.14365800
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.13050808
28interferon-gamma production (GO:0032609)4.07803408
29macrophage activation involved in immune response (GO:0002281)4.02937020
30positive regulation by symbiont of host defense response (GO:0052509)4.00412812
31modulation by symbiont of host defense response (GO:0052031)4.00412812
32modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.00412812
33modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.00412812
34positive regulation by organism of defense response of other organism involved in symbiotic interact4.00412812
35modulation by symbiont of host immune response (GO:0052553)4.00412812
36leukocyte aggregation (GO:0070486)4.00215653
37regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.97443623
38germinal center formation (GO:0002467)3.96046079
39regulation of interleukin-12 biosynthetic process (GO:0045075)3.86398086
40antigen receptor-mediated signaling pathway (GO:0050851)3.80498207
41regulation of podosome assembly (GO:0071801)3.79880842
42regulation of T cell tolerance induction (GO:0002664)3.78939569
43response to muramyl dipeptide (GO:0032495)3.73800223
44positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.71204550
45regulation of B cell differentiation (GO:0045577)3.70103966
46negative regulation of erythrocyte differentiation (GO:0045647)3.62407636
47T cell costimulation (GO:0031295)3.62175713
48regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.61529735
49negative regulation of cytokine production involved in immune response (GO:0002719)3.58016298
50regulation of chronic inflammatory response (GO:0002676)3.58015315
51regulation of vitamin metabolic process (GO:0030656)3.57211413
52regulation of interferon-alpha production (GO:0032647)3.56751267
53lymphocyte costimulation (GO:0031294)3.56624208
54defense response to protozoan (GO:0042832)3.56137554
55response to protozoan (GO:0001562)3.50811194
56immunoglobulin mediated immune response (GO:0016064)3.49123633
57regulation of cytokine secretion involved in immune response (GO:0002739)3.48350263
58positive regulation of heat generation (GO:0031652)3.47207902
59NIK/NF-kappaB signaling (GO:0038061)3.47100211
60negative regulation of lymphocyte mediated immunity (GO:0002707)3.45695619
61positive regulation of chemokine biosynthetic process (GO:0045080)3.45313224
62B cell receptor signaling pathway (GO:0050853)3.44353226
63regulation of T-helper 2 cell differentiation (GO:0045628)3.37599616
64regulation of interferon-beta biosynthetic process (GO:0045357)3.36878834
65regulation of chemokine biosynthetic process (GO:0045073)3.36450785
66regulation of T cell receptor signaling pathway (GO:0050856)3.34291985
67negative regulation of T cell mediated immunity (GO:0002710)3.32987102
68neutrophil activation involved in immune response (GO:0002283)3.32519621
69T-helper 1 type immune response (GO:0042088)3.31468840
70regulation of defense response to virus by virus (GO:0050690)3.28913185
71myeloid dendritic cell differentiation (GO:0043011)3.28566421
72regulation of regulatory T cell differentiation (GO:0045589)3.28437678
73positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.27825445
74regulation of fever generation (GO:0031620)3.27776586
75positive regulation of B cell differentiation (GO:0045579)3.26865218
76positive regulation of type 2 immune response (GO:0002830)3.23966055
77regulation of dendritic cell antigen processing and presentation (GO:0002604)3.23358137
78positive regulation of NF-kappaB import into nucleus (GO:0042346)3.19221442
79positive regulation of tolerance induction (GO:0002645)3.16065582
80positive regulation of interleukin-2 production (GO:0032743)3.15550240
81mast cell activation (GO:0045576)3.14391266
82regulation of type I interferon-mediated signaling pathway (GO:0060338)3.10735881
83positive regulation of interferon-alpha production (GO:0032727)3.10300102
84JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.09181081
85tolerance induction (GO:0002507)3.07124272
86regulation of natural killer cell mediated immunity (GO:0002715)3.05457436
87regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.05457436
88positive regulation of histone deacetylation (GO:0031065)3.05260150
89negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.05077818
90regulation of alpha-beta T cell proliferation (GO:0046640)3.04463569
91regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.03824246
92T cell homeostasis (GO:0043029)3.02639632
93natural killer cell differentiation (GO:0001779)2.99701660
94response to type I interferon (GO:0034340)2.99679965
95activation of MAPKKK activity (GO:0000185)2.99497437
96activated T cell proliferation (GO:0050798)2.96038937
97regulation of interleukin-2 biosynthetic process (GO:0045076)2.94510724
98negative regulation of leukocyte mediated immunity (GO:0002704)2.94005403
99cellular response to type I interferon (GO:0071357)2.93667414
100type I interferon signaling pathway (GO:0060337)2.93667414
101negative regulation of myeloid cell apoptotic process (GO:0033033)2.92114509
102regulation of membrane protein ectodomain proteolysis (GO:0051043)2.92002275
103regulation of T-helper cell differentiation (GO:0045622)2.91362419
104detection of molecule of bacterial origin (GO:0032490)2.90255616
105positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.90124988
106mannose metabolic process (GO:0006013)2.88544407
107leukocyte cell-cell adhesion (GO:0007159)2.88238091
108regulation of interleukin-12 production (GO:0032655)2.87908107
109positive regulation of transcription factor import into nucleus (GO:0042993)2.85821361
110mast cell activation involved in immune response (GO:0002279)2.85146841
111mast cell degranulation (GO:0043303)2.85146841
112regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.84301613
113positive regulation of T-helper cell differentiation (GO:0045624)2.84097705
114immune response-activating cell surface receptor signaling pathway (GO:0002429)2.83460113
115regulation of type 2 immune response (GO:0002828)2.83205920
116regulation of tolerance induction (GO:0002643)2.82698854
117detection of other organism (GO:0098543)2.82268067
118negative regulation of production of molecular mediator of immune response (GO:0002701)2.81434662
119regulation of isotype switching (GO:0045191)2.80540375
120positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.80422667
121positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.80357007
122natural killer cell activation (GO:0030101)2.80261694
123myeloid dendritic cell activation (GO:0001773)2.80213757
124granulocyte activation (GO:0036230)2.79650431
125modulation by symbiont of host cellular process (GO:0044068)2.79151670
126positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.78904224
127positive regulation of isotype switching (GO:0045830)2.78497880
128positive regulation of humoral immune response (GO:0002922)2.78424327
129regulation of interferon-gamma biosynthetic process (GO:0045072)2.78317811
130branching involved in labyrinthine layer morphogenesis (GO:0060670)2.77732627
131cellular response to lipopolysaccharide (GO:0071222)2.75348044
132positive regulation of granulocyte differentiation (GO:0030854)2.73895214
133regulation of response to interferon-gamma (GO:0060330)2.72179915
134positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.72101731
135detection of bacterium (GO:0016045)2.70770968
136cellular response to virus (GO:0098586)2.70672563
137positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.70616248
138positive regulation of natural killer cell mediated immunity (GO:0002717)2.70616248
139negative regulation of innate immune response (GO:0045824)2.70416133
140regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.70356510
141cellular response to molecule of bacterial origin (GO:0071219)2.70229097
142positive regulation of Rap GTPase activity (GO:0032854)2.70192553
143T cell differentiation (GO:0030217)2.68435492
144regulation of interleukin-2 production (GO:0032663)2.67761405
145regulation of leukocyte mediated cytotoxicity (GO:0001910)2.67616921
146interferon-gamma-mediated signaling pathway (GO:0060333)2.67320723
147lymphocyte homeostasis (GO:0002260)2.67265089
148interferon-gamma secretion (GO:0072643)2.66341370
149response to host immune response (GO:0052572)2.65907940
150response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.65907940
151positive regulation of lamellipodium assembly (GO:0010592)2.64344466
152myeloid cell activation involved in immune response (GO:0002275)2.64037084
153negative regulation of tumor necrosis factor production (GO:0032720)2.63722096
154regulation of antigen processing and presentation (GO:0002577)2.63668128
155detection of external biotic stimulus (GO:0098581)2.61763061
156positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.61566982
157CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.60172325
158positive regulation of interferon-beta production (GO:0032728)2.59839945
159mature B cell differentiation (GO:0002335)2.59834078
160regulation of NF-kappaB import into nucleus (GO:0042345)2.59763385
161positive regulation of acute inflammatory response (GO:0002675)2.59373565
162positive regulation of interleukin-17 production (GO:0032740)2.59197917
163negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.58685618
164negative regulation of interleukin-6 production (GO:0032715)2.58521679
165histone H3-K4 trimethylation (GO:0080182)2.57288190
166regulation of immunoglobulin mediated immune response (GO:0002889)2.57035754
167negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.55541124
168T cell proliferation (GO:0042098)2.55087075
169regulation of B cell mediated immunity (GO:0002712)2.53923742
170negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.53650274
171negative regulation of adaptive immune response (GO:0002820)2.51322903
172alpha-beta T cell activation (GO:0046631)2.49998089
173regulation of cell killing (GO:0031341)2.49842359
174negative regulation of interleukin-12 production (GO:0032695)2.48787378
175T cell activation (GO:0042110)2.46970006
176positive regulation of B cell mediated immunity (GO:0002714)2.45787072
177positive regulation of immunoglobulin mediated immune response (GO:0002891)2.45787072
178leukocyte homeostasis (GO:0001776)2.45510083

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.26417637
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.01135018
3MYC_22102868_ChIP-Seq_BL_Human4.29898425
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.92034908
5RUNX_20019798_ChIP-Seq_JUKART_Human3.22496244
6VDR_21846776_ChIP-Seq_THP-1_Human3.21659261
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.19620780
8* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.10372537
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.90308368
10* MAF_26560356_Chip-Seq_TH1_Human2.88590568
11UTX_26944678_Chip-Seq_JUKART_Human2.84004501
12* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.80805858
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.80601630
14TCF7_22412390_ChIP-Seq_EML_Mouse2.80000885
15KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.74762673
16MYB_26560356_Chip-Seq_TH2_Human2.69221741
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.68970745
18KDM2B_26808549_Chip-Seq_DND41_Human2.68703838
19* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.63252180
20* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.63168921
21SCL_19346495_ChIP-Seq_HPC-7_Human2.58823905
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.51031344
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.43054618
24* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.42201436
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.38505874
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.36516029
27MYB_26560356_Chip-Seq_TH1_Human2.35035533
28* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.21236610
29VDR_24763502_ChIP-Seq_THP-1_Human2.19586186
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.12911684
31SPI1_23127762_ChIP-Seq_K562_Human2.07250271
32MAF_26560356_Chip-Seq_TH2_Human2.02946937
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.99551546
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95559430
35CIITA_25753668_ChIP-Seq_RAJI_Human1.94976816
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88277579
37KDM2B_26808549_Chip-Seq_JURKAT_Human1.87187562
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.85521307
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84161697
40IRF8_21731497_ChIP-ChIP_J774_Mouse1.83749202
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79422728
42* ELK3_25401928_ChIP-Seq_HUVEC_Human1.76333049
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.75359564
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.74940443
45LXR_22292898_ChIP-Seq_THP-1_Human1.73096994
46GATA3_27048872_Chip-Seq_THYMUS_Human1.72588530
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.67027782
48IRF8_27001747_Chip-Seq_BMDM_Mouse1.66126831
49RACK7_27058665_Chip-Seq_MCF-7_Human1.64356990
50SPI1_23547873_ChIP-Seq_NB4_Human1.62505242
51MYB_21317192_ChIP-Seq_ERMYB_Mouse1.61628281
52* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53619369
53* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52213076
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.50205336
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45588259
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.41804190
57* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41703377
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40147826
59TP63_17297297_ChIP-ChIP_HaCaT_Human1.38303239
60PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37066063
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35555606
62* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34811168
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33866273
64* ESR2_21235772_ChIP-Seq_MCF-7_Human1.33716143
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33359772
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32225693
67* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30324210
68ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28277239
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26837630
70RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.26726440
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24484562
72GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.23144668
73BCOR_27268052_Chip-Seq_Bcells_Human1.22857758
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22789667
75Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.21727122
76KDM2B_26808549_Chip-Seq_K562_Human1.21651552
77LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21632905
78RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20841317
79ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19434992
80* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19268789
81* GATA1_19941827_ChIP-Seq_MEL_Mouse1.18010148
82SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17165664
83DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17139877
84PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14566790
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13837546
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13137078
87SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13099138
88SMC4_20622854_ChIP-Seq_HELA_Human1.13066680
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12061274
90DROSHA_22980978_ChIP-Seq_HELA_Human1.11567454
91RARB_27405468_Chip-Seq_BRAIN_Mouse1.10720543
92BP1_19119308_ChIP-ChIP_Hs578T_Human1.10563955
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09450811
94TET1_21451524_ChIP-Seq_MESCs_Mouse1.09124572
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08736832
96ERG_21242973_ChIP-ChIP_JURKAT_Human1.07900554
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07305990
98PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.07090455
99VDR_24787735_ChIP-Seq_THP-1_Human1.05453565
100ELF1_20517297_ChIP-Seq_JURKAT_Human1.03588664
101KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.02778041
102KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.02778041
103KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.02778041
104SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.02378997
105RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01941333
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01940973
107CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01411066
108* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00905077
109CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00864573
110CTCF_26484167_Chip-Seq_Bcells_Mouse0.99680234
111CREB1_26743006_Chip-Seq_LNCaP_Human0.99615519
112GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99257027
113DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98250262
114PU_27001747_Chip-Seq_BMDM_Mouse0.96640563
115* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96239285
116CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96156641
117CTCF_21964334_ChIP-Seq_BJAB-B_Human0.95301005
118STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95008270
119SA1_27219007_Chip-Seq_ERYTHROID_Human0.94962896
120GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93276015
121SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93144014
122GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91290467
123NCOR1_26117541_ChIP-Seq_K562_Human0.88156884
124PKCTHETA_26484144_Chip-Seq_BREAST_Human0.87171915
125P68_20966046_ChIP-Seq_HELA_Human0.87102069
126BCL6_27268052_Chip-Seq_Bcells_Human0.86639042
127PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86235521
128GATA1_19941826_ChIP-Seq_K562_Human0.83845977
129* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.83465755

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.51720770
2MP0005671_abnormal_response_to3.74372803
3MP0000685_abnormal_immune_system3.57343511
4MP0001835_abnormal_antigen_presentation3.01834936
5MP0001800_abnormal_humoral_immune2.83511130
6MP0002396_abnormal_hematopoietic_system2.77983034
7MP0008961_abnormal_basal_metabolism2.66939707
8MP0001790_abnormal_immune_system2.61076231
9MP0005387_immune_system_phenotype2.61076231
10MP0005451_abnormal_body_composition2.61057502
11MP0002398_abnormal_bone_marrow2.57901073
12MP0002420_abnormal_adaptive_immunity2.55729645
13MP0003303_peritoneal_inflammation2.54557467
14MP0001819_abnormal_immune_cell2.52802143
15MP0002166_altered_tumor_susceptibility2.51947599
16MP0002723_abnormal_immune_serum2.51137797
17MP0005000_abnormal_immune_tolerance2.50393246
18MP0000569_abnormal_digit_pigmentation2.46898972
19MP0002452_abnormal_antigen_presenting2.36776821
20MP0000703_abnormal_thymus_morphology2.30447444
21MP0003300_gastrointestinal_ulcer2.23014997
22MP0004510_myositis2.18297639
23MP0002254_reproductive_system_inflammat2.17974479
24MP0000716_abnormal_immune_system2.17867932
25MP0009785_altered_susceptibility_to2.17130657
26MP0005025_abnormal_response_to2.13066314
27MP0009840_abnormal_foam_cell2.08845183
28MP0004859_abnormal_synaptic_plasticity2.05571258
29MP0002405_respiratory_system_inflammati2.02489509
30MP0003436_decreased_susceptibility_to2.00283180
31MP0001873_stomach_inflammation1.95735246
32MP0003172_abnormal_lysosome_physiology1.95331925
33MP0002722_abnormal_immune_system1.94432386
34MP0003866_abnormal_defecation1.93955012
35MP0002006_tumorigenesis1.93941888
36MP0003075_altered_response_to1.92320438
37MP0009764_decreased_sensitivity_to1.92279111
38MP0000689_abnormal_spleen_morphology1.88605054
39MP0008004_abnormal_stomach_pH1.87952894
40MP0003183_abnormal_peptide_metabolism1.82913318
41MP0004808_abnormal_hematopoietic_stem1.79096925
42MP0002419_abnormal_innate_immunity1.77787026
43MP0009278_abnormal_bone_marrow1.76944185
44MP0005464_abnormal_platelet_physiology1.76653275
45MP0002429_abnormal_blood_cell1.76445905
46MP0009333_abnormal_splenocyte_physiolog1.75654342
47MP0004947_skin_inflammation1.75056684
48MP0010155_abnormal_intestine_physiology1.72620773
49MP0006082_CNS_inflammation1.70343403
50MP0002933_joint_inflammation1.66369106
51MP0005174_abnormal_tail_pigmentation1.61432060
52MP0005167_abnormal_blood-brain_barrier1.58729084
53MP0003453_abnormal_keratinocyte_physiol1.57020999
54MP0000343_altered_response_to1.40351466
55MP0001845_abnormal_inflammatory_respons1.35745751
56MP0002332_abnormal_exercise_endurance1.35157137
57MP0008260_abnormal_autophagy1.34550082
58MP0002148_abnormal_hypersensitivity_rea1.30208560
59MP0002909_abnormal_adrenal_gland1.25015429
60MP0003191_abnormal_cellular_cholesterol1.23938357
61MP0005423_abnormal_somatic_nervous1.23358286
62MP0000465_gastrointestinal_hemorrhage1.22620385
63MP0005166_decreased_susceptibility_to1.21792439
64MP0003724_increased_susceptibility_to1.20515603
65MP0003787_abnormal_imprinting1.15199004
66MP0005397_hematopoietic_system_phenotyp1.14884725
67MP0001545_abnormal_hematopoietic_system1.14884725
68MP0005076_abnormal_cell_differentiation1.10479118
69MP0008569_lethality_at_weaning1.09927749
70MP0005390_skeleton_phenotype1.09407988
71MP0005075_abnormal_melanosome_morpholog1.08370773
72MP0003690_abnormal_glial_cell1.07857871
73MP0000015_abnormal_ear_pigmentation1.06298954
74MP0003705_abnormal_hypodermis_morpholog1.06044171
75MP0002139_abnormal_hepatobiliary_system1.05058509
76MP0003122_maternal_imprinting0.98586918
77MP0000858_altered_metastatic_potential0.97503761
78MP0001663_abnormal_digestive_system0.96239516
79MP0000678_abnormal_parathyroid_gland0.94974931
80MP0002998_abnormal_bone_remodeling0.94506887
81MP0005310_abnormal_salivary_gland0.92700037
82MP0000371_diluted_coat_color0.92604377
83MP0003635_abnormal_synaptic_transmissio0.90008798
84MP0001853_heart_inflammation0.86421535
85MP0004130_abnormal_muscle_cell0.86342035
86MP0003656_abnormal_erythrocyte_physiolo0.85422361
87MP0001533_abnormal_skeleton_physiology0.85185532
88MP0001851_eye_inflammation0.84608378
89MP0000490_abnormal_crypts_of0.83804929
90MP0003279_aneurysm0.83429458
91MP0002138_abnormal_hepatobiliary_system0.80815083
92MP0005666_abnormal_adipose_tissue0.79627222
93MP0006054_spinal_hemorrhage0.79386867
94MP0005164_abnormal_response_to0.79217228
95MP0005645_abnormal_hypothalamus_physiol0.77426236
96MP0002095_abnormal_skin_pigmentation0.76034052
97MP0008469_abnormal_protein_level0.75567485
98MP0002693_abnormal_pancreas_physiology0.75085362
99MP0009763_increased_sensitivity_to0.75077161
100MP0003091_abnormal_cell_migration0.73240767
101MP0004811_abnormal_neuron_physiology0.73060355
102MP0005023_abnormal_wound_healing0.72683692
103MP0002089_abnormal_postnatal_growth/wei0.72561658
104MP0003448_altered_tumor_morphology0.72167251
105MP0003828_pulmonary_edema0.71418349
106MP0002928_abnormal_bile_duct0.71118085
107MP0003806_abnormal_nucleotide_metabolis0.70368787
108MP0002019_abnormal_tumor_incidence0.69852128
109MP0009765_abnormal_xenobiotic_induced0.67973945
110MP0000249_abnormal_blood_vessel0.67956360
111MP0004185_abnormal_adipocyte_glucose0.67929925
112MP0003329_amyloid_beta_deposits0.67552150
113MP0002877_abnormal_melanocyte_morpholog0.67122262
114MP0003045_fibrosis0.65936179
115MP0001348_abnormal_lacrimal_gland0.65105637
116MP0004858_abnormal_nervous_system0.64887807
117MP0005381_digestive/alimentary_phenotyp0.63962602
118MP0005375_adipose_tissue_phenotype0.62887124
119MP0003121_genomic_imprinting0.62556765
120MP0002277_abnormal_respiratory_mucosa0.61380020
121MP0004883_abnormal_blood_vessel0.58369682
122MP0005058_abnormal_lysosome_morphology0.57287391
123MP0003959_abnormal_lean_body0.56114873
124MP0003646_muscle_fatigue0.55174797
125MP0000767_abnormal_smooth_muscle0.55100564
126MP0002063_abnormal_learning/memory/cond0.55026902
127MP0008770_decreased_survivor_rate0.53838692
128MP0001502_abnormal_circadian_rhythm0.52916314
129MP0002083_premature_death0.52319049
130MP0008874_decreased_physiological_sensi0.47572596
131MP0010352_gastrointestinal_tract_polyps0.44429684
132MP0000604_amyloidosis0.44040485
133MP0001944_abnormal_pancreas_morphology0.43125250
134MP0002075_abnormal_coat/hair_pigmentati0.42767926
135MP0003795_abnormal_bone_structure0.42425428
136MP0000477_abnormal_intestine_morphology0.41663153
137MP0001849_ear_inflammation0.41487003
138MP0002557_abnormal_social/conspecific_i0.40851509
139MP0009745_abnormal_behavioral_response0.40346278
140MP0002822_catalepsy0.40095958

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.77295766
2T lymphocytopenia (HP:0005403)4.69124031
3Abnormality of glycolipid metabolism (HP:0010969)4.63843234
4Abnormality of liposaccharide metabolism (HP:0010968)4.63843234
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.63843234
6Abnormality of macrophages (HP:0004311)4.50414875
7Abnormality of T cell number (HP:0011839)4.43491496
8Recurrent bronchitis (HP:0002837)4.01112640
9Severe combined immunodeficiency (HP:0004430)3.91070744
10Recurrent fungal infections (HP:0002841)3.79727247
11Chronic mucocutaneous candidiasis (HP:0002728)3.77877159
12Recurrent cutaneous fungal infections (HP:0011370)3.77877159
13Dysostosis multiplex (HP:0000943)3.69596177
14Abnormality of the fingertips (HP:0001211)3.67022243
15Panhypogammaglobulinemia (HP:0003139)3.66263061
16Abnormality of T cells (HP:0002843)3.54027862
17Increased cerebral lipofuscin (HP:0011813)3.53142518
18Stomatitis (HP:0010280)3.51344551
19Thyroiditis (HP:0100646)3.44889775
20Loss of speech (HP:0002371)3.38926711
21Myositis (HP:0100614)3.38726102
22Recurrent viral infections (HP:0004429)3.38080661
23Combined immunodeficiency (HP:0005387)3.33995404
24Chronic otitis media (HP:0000389)3.33195190
25Systemic lupus erythematosus (HP:0002725)3.29920036
26Abnormal delayed hypersensitivity skin test (HP:0002963)3.27075019
27IgM deficiency (HP:0002850)3.25811613
28Hyperacusis (HP:0010780)3.19216973
29Keratoconjunctivitis sicca (HP:0001097)3.14705263
30Recurrent gram-negative bacterial infections (HP:0005420)3.13142279
31Nasal polyposis (HP:0100582)3.01103475
32Gastrointestinal infarctions (HP:0005244)2.93547050
33Increased neuronal autofluorescent lipopigment (HP:0002074)2.93001514
34Abnormality of mucopolysaccharide metabolism (HP:0011020)2.88981015
35Abnormality of polysaccharide metabolism (HP:0011012)2.88981015
36Abnormality of glycosaminoglycan metabolism (HP:0004371)2.88981015
37Eczematoid dermatitis (HP:0000976)2.83355995
38Chronic diarrhea (HP:0002028)2.82225806
39Vacuolated lymphocytes (HP:0001922)2.81938502
40Keratoconjunctivitis (HP:0001096)2.80081511
41Interstitial pulmonary disease (HP:0006530)2.78105341
42Increased IgM level (HP:0003496)2.77997138
43Abnormality of the nasal mucosa (HP:0000433)2.75230316
44Hypoplasia of the thymus (HP:0000778)2.74561211
45Agammaglobulinemia (HP:0004432)2.73939829
46Nuclear cataract (HP:0100018)2.73117079
47Increased serum ferritin (HP:0003281)2.71943414
48Urinary glycosaminoglycan excretion (HP:0003541)2.71648773
49Mucopolysacchariduria (HP:0008155)2.71648773
50B lymphocytopenia (HP:0010976)2.71297115
51Abnormality of B cell number (HP:0010975)2.71297115
52IgG deficiency (HP:0004315)2.66878805
53Gastrointestinal inflammation (HP:0004386)2.66331536
54Disinhibition (HP:0000734)2.62024816
55Abnormality of eosinophils (HP:0001879)2.61927862
56Recurrent abscess formation (HP:0002722)2.60490676
57Inflammation of the large intestine (HP:0002037)2.59564160
58Lymphopenia (HP:0001888)2.58622981
59Mediastinal lymphadenopathy (HP:0100721)2.58024058
60Abnormality of cells of the lymphoid lineage (HP:0012140)2.51109301
61Neurofibrillary tangles (HP:0002185)2.44285548
62Thin bony cortex (HP:0002753)2.44069377
63Purpura (HP:0000979)2.40129976
64Amyloidosis (HP:0011034)2.36678247
65Hemoptysis (HP:0002105)2.35683853
66Macroorchidism (HP:0000053)2.33245400
67Meningitis (HP:0001287)2.32798164
68Recurrent skin infections (HP:0001581)2.32592768
69Abnormality of T cell physiology (HP:0011840)2.32316363
70Encephalitis (HP:0002383)2.32047063
71Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.31630505
72Leukocytosis (HP:0001974)2.30952814
73Segmental peripheral demyelination/remyelination (HP:0003481)2.24750537
74Spinal canal stenosis (HP:0003416)2.24513657
75Chest pain (HP:0100749)2.24247551
76Amyotrophic lateral sclerosis (HP:0007354)2.22582725
77Gangrene (HP:0100758)2.19661396
78Hypertensive crisis (HP:0100735)2.18153927
79Acne (HP:0001061)2.17402310
80Frequent falls (HP:0002359)2.16948431
81Thoracic kyphosis (HP:0002942)2.16756976
82Basal cell carcinoma (HP:0002671)2.15564997
83Thrombocytosis (HP:0001894)2.14682612
84Abnormality of the endocardium (HP:0004306)2.14022219
85Glomerulonephritis (HP:0000099)2.12747374
86Retrobulbar optic neuritis (HP:0100654)2.12398598
87Optic neuritis (HP:0100653)2.12398598
88Hematochezia (HP:0002573)2.11321890
89Colitis (HP:0002583)2.11013235
90Neuronal loss in central nervous system (HP:0002529)2.10787509
91Mutism (HP:0002300)2.10112722
92Large eyes (HP:0001090)2.09272189
93Polygenic inheritance (HP:0010982)2.08181547
94Anorexia (HP:0002039)2.07990838
95Episodic fever (HP:0001954)2.07958497
96Elfin facies (HP:0004428)2.07226848
97Autoimmune thrombocytopenia (HP:0001973)2.06972436
98Abnormality of iron homeostasis (HP:0011031)2.05964701
99Vasculitis (HP:0002633)2.05626606
100Prolonged bleeding time (HP:0003010)2.05017000
101Axonal loss (HP:0003447)2.04730430
102Urticaria (HP:0001025)2.04002451
103Progressive neurologic deterioration (HP:0002344)2.03240139
104Recurrent bacterial skin infections (HP:0005406)2.02868310
105Pustule (HP:0200039)2.00761987
106Increased IgE level (HP:0003212)2.00655395
107Orchitis (HP:0100796)1.99559109
108Increased density of long bones (HP:0006392)1.98614885
109Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.98574321
110Bronchitis (HP:0012387)1.98541476
111Abnormality of the pleura (HP:0002103)1.97242206
112Eosinophilia (HP:0001880)1.96832235
113Apathy (HP:0000741)1.96080255
114Cerebral aneurysm (HP:0004944)1.94915898
115Pulmonary infiltrates (HP:0002113)1.94818412
116Papilloma (HP:0012740)1.93411870
117Verrucae (HP:0200043)1.93411870
118Diminished motivation (HP:0000745)1.93206544
119Pulmonary embolism (HP:0002204)1.91818872
120Petechiae (HP:0000967)1.91149115
121Cerebral inclusion bodies (HP:0100314)1.90662935
122Hepatosplenomegaly (HP:0001433)1.90365151
123Poikiloderma (HP:0001029)1.89653448
124Chronic sinusitis (HP:0011109)1.89481077
125Pointed chin (HP:0000307)1.89102058
126Deep palmar crease (HP:0006191)1.88166269
127Recurrent sinusitis (HP:0011108)1.88134378
128Acute lymphatic leukemia (HP:0006721)1.87969337
129Emphysema (HP:0002097)1.87931386
130Restrictive lung disease (HP:0002091)1.87170220
131Cellulitis (HP:0100658)1.86584925
132Insomnia (HP:0100785)1.86376268
133Gingivitis (HP:0000230)1.83622271
134Autoimmune hemolytic anemia (HP:0001890)1.81808655
135Obstructive sleep apnea (HP:0002870)1.81057268
136Arthralgia (HP:0002829)1.81007877
137Abnormality of the thoracic spine (HP:0100711)1.79340840
138Arterial thrombosis (HP:0004420)1.78536516
139Joint swelling (HP:0001386)1.77952824
140Cheilitis (HP:0100825)1.77520942
141Hypergammaglobulinemia (HP:0010702)1.77182649
142Heterotopia (HP:0002282)1.76124102
143Papilledema (HP:0001085)1.75824153
144Spontaneous hematomas (HP:0007420)1.74257776
145Bicuspid aortic valve (HP:0001647)1.73758728
146Gastrointestinal stroma tumor (HP:0100723)1.73163587
147Striae distensae (HP:0001065)1.72974370
148Lymphoma (HP:0002665)1.72355389
149Ureteral stenosis (HP:0000071)1.71466965
150Fatigue (HP:0012378)1.71109539
151Neoplasm of the heart (HP:0100544)1.70266922
152Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.68565943
153Urinary urgency (HP:0000012)1.68270178
154Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.68109219
155IgA deficiency (HP:0002720)1.66845870
156Obsessive-compulsive behavior (HP:0000722)1.65208357
157Obstructive lung disease (HP:0006536)1.64884369
158Chronic obstructive pulmonary disease (HP:0006510)1.64884369
159Broad palm (HP:0001169)1.64343186

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.73158201
2IRAK34.13608742
3TXK3.56695118
4PRPF4B2.99545779
5FGFR42.89116150
6JAK32.76547382
7NME22.68996854
8SIK22.58436054
9MAP3K102.55726073
10ZAP702.46078660
11TAOK22.42505446
12IKBKE2.38511668
13MAP3K112.26711836
14KIT2.23856951
15TYK22.21838038
16ITK2.19894845
17EEF2K2.17556313
18MAP2K32.03099312
19SMG12.00504173
20MATK1.97943382
21TRIB31.95703907
22PKN21.93024679
23DDR21.88814938
24TBK11.83722473
25FGFR31.80037234
26JAK11.79793973
27SIK31.73912058
28FLT31.70158019
29CDC42BPA1.67477165
30MAP3K31.60908103
31FGR1.57135177
32SYK1.51408666
33GRK61.50058062
34LCK1.46994357
35CSF1R1.45871643
36NTRK21.45115479
37MAP3K131.44072830
38HCK1.44062257
39GRK71.41197790
40MARK21.38615996
41BTK1.36199980
42FES1.34189917
43MARK11.33718481
44IRAK41.33603773
45ERN11.30785634
46MAP3K11.28858510
47PRKCH1.26984304
48TYRO31.25141519
49NLK1.24670424
50MAP3K71.23757100
51RIPK11.16303645
52PIM21.08124510
53CSK1.05177906
54TGFBR21.04884533
55TEC1.03956066
56CAMK1G1.03375836
57TAOK11.00588713
58HIPK20.98715430
59MOS0.97511388
60MAP3K140.95597512
61BLK0.94566269
62RIPK40.88993917
63MARK30.86542101
64SIK10.86314641
65KDR0.85497907
66JAK20.84099242
67TNK20.83892294
68STK100.83524165
69TNIK0.77140747
70PDGFRB0.77068558
71BRD40.74301192
72RET0.71991330
73RPS6KC10.71202550
74RPS6KL10.71202550
75PDGFRA0.70829088
76BMX0.68431203
77TTN0.68097610
78PRKD20.65848284
79LYN0.65667302
80CAMK1D0.65552122
81SCYL20.65188186
82PTK60.64061471
83TGFBR10.62287782
84MAP3K90.61596285
85DAPK10.60952161
86UHMK10.60240977
87ALK0.58050973
88RPS6KA60.57066093
89CHUK0.56722296
90MAP2K60.56150720
91PDPK10.56061216
92PRKCQ0.55290150
93BMPR20.55183949
94PASK0.54917462
95ARAF0.54471814
96CAMKK10.54085867
97EPHB10.53452225
98LRRK20.53399052
99CLK10.53136139
100IKBKB0.51423492
101PDK10.50913368
102KSR20.50704995
103FYN0.50507844
104CAMKK20.49668847
105DMPK0.48591244
106CDK40.47840723
107TESK20.47323695
108CDK120.46335608
109MAP3K50.45542682
110DAPK20.45396038
111FGFR20.45296531
112MAP3K120.44874509
113MAPK70.44051002
114CAMK10.43273524
115EPHA30.42864082
116DYRK30.42726055
117DYRK1B0.42182108
118MAPK120.41690201
119PIM10.41593087
120MAPK110.41121818
121IRAK10.37899584
122MAPK40.34622338
123ICK0.34399048
124IRAK20.34351261
125ABL20.34161800
126CAMK40.33811228
127MTOR0.33549589
128MAPK90.32633336
129CDK50.32310563
130RPS6KA10.31984646
131MAPK130.30770116
132KSR10.30583856
133TAOK30.28669016
134RPS6KA20.28498284

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.54403286
2T cell receptor signaling pathway_Homo sapiens_hsa046602.60957677
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.23151684
4Malaria_Homo sapiens_hsa051442.18106525
5B cell receptor signaling pathway_Homo sapiens_hsa046622.06631600
6Staphylococcus aureus infection_Homo sapiens_hsa051501.93932780
7Osteoclast differentiation_Homo sapiens_hsa043801.88278401
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.87224722
9Measles_Homo sapiens_hsa051621.84415937
10African trypanosomiasis_Homo sapiens_hsa051431.81635814
11Rheumatoid arthritis_Homo sapiens_hsa053231.76557549
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.72999616
13Leishmaniasis_Homo sapiens_hsa051401.71769155
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.69942354
15Asthma_Homo sapiens_hsa053101.69745563
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.63259116
17Autoimmune thyroid disease_Homo sapiens_hsa053201.62086637
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.55449758
19Lysosome_Homo sapiens_hsa041421.52104228
20Acute myeloid leukemia_Homo sapiens_hsa052211.50299454
21Hematopoietic cell lineage_Homo sapiens_hsa046401.42662138
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.42481689
23Neurotrophin signaling pathway_Homo sapiens_hsa047221.37400868
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36651001
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.35373538
26Chemokine signaling pathway_Homo sapiens_hsa040621.33989294
27Chronic myeloid leukemia_Homo sapiens_hsa052201.33716396
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.33629596
29Colorectal cancer_Homo sapiens_hsa052101.33404843
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.32251284
31Viral myocarditis_Homo sapiens_hsa054161.31984467
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31876829
33Antigen processing and presentation_Homo sapiens_hsa046121.31778177
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25924029
35Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.22046746
36VEGF signaling pathway_Homo sapiens_hsa043701.21678187
37Toxoplasmosis_Homo sapiens_hsa051451.19664745
38Bladder cancer_Homo sapiens_hsa052191.17418897
39Pancreatic cancer_Homo sapiens_hsa052121.16285150
40Hepatitis B_Homo sapiens_hsa051611.16042390
41Notch signaling pathway_Homo sapiens_hsa043301.15739687
42Prion diseases_Homo sapiens_hsa050201.14350762
43Herpes simplex infection_Homo sapiens_hsa051681.13627340
44Shigellosis_Homo sapiens_hsa051311.11899518
45Allograft rejection_Homo sapiens_hsa053301.11084044
46Type II diabetes mellitus_Homo sapiens_hsa049301.09218127
47Prolactin signaling pathway_Homo sapiens_hsa049171.08073632
48Influenza A_Homo sapiens_hsa051641.07514466
49Platelet activation_Homo sapiens_hsa046111.06110826
50Non-small cell lung cancer_Homo sapiens_hsa052231.05349506
51TNF signaling pathway_Homo sapiens_hsa046681.04430467
52Adipocytokine signaling pathway_Homo sapiens_hsa049201.04016434
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02834372
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99623843
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.99432877
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98394044
57Amoebiasis_Homo sapiens_hsa051460.96384731
58Type I diabetes mellitus_Homo sapiens_hsa049400.96189052
59Endometrial cancer_Homo sapiens_hsa052130.95303346
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94251579
61HTLV-I infection_Homo sapiens_hsa051660.90074540
62NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89533072
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88121610
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88089938
65Graft-versus-host disease_Homo sapiens_hsa053320.86631179
66Tuberculosis_Homo sapiens_hsa051520.85932108
67mTOR signaling pathway_Homo sapiens_hsa041500.85928998
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84222752
69Apoptosis_Homo sapiens_hsa042100.83444167
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81600193
71Phagosome_Homo sapiens_hsa041450.80026496
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78378453
73Salmonella infection_Homo sapiens_hsa051320.77253661
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76876305
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76212755
76MAPK signaling pathway_Homo sapiens_hsa040100.74421184
77Choline metabolism in cancer_Homo sapiens_hsa052310.72872598
78Long-term potentiation_Homo sapiens_hsa047200.72777257
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.71934679
80Estrogen signaling pathway_Homo sapiens_hsa049150.71826995
81Cholinergic synapse_Homo sapiens_hsa047250.71779255
82Glioma_Homo sapiens_hsa052140.71479456
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70144649
84Morphine addiction_Homo sapiens_hsa050320.70098089
85Hepatitis C_Homo sapiens_hsa051600.69495749
86Endocytosis_Homo sapiens_hsa041440.69159197
87Renal cell carcinoma_Homo sapiens_hsa052110.69133831
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68770362
89Rap1 signaling pathway_Homo sapiens_hsa040150.67853341
90Insulin resistance_Homo sapiens_hsa049310.67433050
91ErbB signaling pathway_Homo sapiens_hsa040120.66412020
92Pertussis_Homo sapiens_hsa051330.66160573
93Oxytocin signaling pathway_Homo sapiens_hsa049210.64423803
94Circadian entrainment_Homo sapiens_hsa047130.64275314
95Insulin secretion_Homo sapiens_hsa049110.64217786
96Olfactory transduction_Homo sapiens_hsa047400.63408430
97Epstein-Barr virus infection_Homo sapiens_hsa051690.62480140
98Cocaine addiction_Homo sapiens_hsa050300.61981039
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.61941602
100Dopaminergic synapse_Homo sapiens_hsa047280.61553130
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61233221
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61084420
103Viral carcinogenesis_Homo sapiens_hsa052030.56448476
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56444768
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55628705
106Insulin signaling pathway_Homo sapiens_hsa049100.54482019
107Inositol phosphate metabolism_Homo sapiens_hsa005620.54414803
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53412852
109Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52290728
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51215906
111GnRH signaling pathway_Homo sapiens_hsa049120.51101691
112HIF-1 signaling pathway_Homo sapiens_hsa040660.50730238
113Galactose metabolism_Homo sapiens_hsa000520.49202284
114Gastric acid secretion_Homo sapiens_hsa049710.49090995
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.48337247
116Other glycan degradation_Homo sapiens_hsa005110.48119262
117Legionellosis_Homo sapiens_hsa051340.47452856
118Thyroid cancer_Homo sapiens_hsa052160.47424484
119cAMP signaling pathway_Homo sapiens_hsa040240.47311193
120FoxO signaling pathway_Homo sapiens_hsa040680.45268774
121Fructose and mannose metabolism_Homo sapiens_hsa000510.44939949
122Small cell lung cancer_Homo sapiens_hsa052220.38363226
123Prostate cancer_Homo sapiens_hsa052150.36712682
124Sphingolipid metabolism_Homo sapiens_hsa006000.31514989
125Dorso-ventral axis formation_Homo sapiens_hsa043200.29777174

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