GPX7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)6.38229824
2translational termination (GO:0006415)6.16831287
3collagen fibril organization (GO:0030199)5.95031038
4ribosomal small subunit assembly (GO:0000028)5.62109218
5establishment of protein localization to endoplasmic reticulum (GO:0072599)5.37900107
6protein localization to endoplasmic reticulum (GO:0070972)5.31482309
7translational elongation (GO:0006414)5.12787717
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.10229612
9chaperone-mediated protein transport (GO:0072321)4.90755665
10extracellular fibril organization (GO:0043206)4.75595689
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.64592499
12viral life cycle (GO:0019058)4.62947770
13ATP synthesis coupled proton transport (GO:0015986)4.61752255
14energy coupled proton transport, down electrochemical gradient (GO:0015985)4.61752255
15cellular protein complex disassembly (GO:0043624)4.59018001
16keratan sulfate catabolic process (GO:0042340)4.58519937
17chondrocyte proliferation (GO:0035988)4.58275656
18notochord development (GO:0030903)4.43619293
19ribosomal small subunit biogenesis (GO:0042274)4.41599075
20establishment of protein localization to mitochondrial membrane (GO:0090151)4.41155140
21bone trabecula formation (GO:0060346)4.40056177
22cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.33301922
23nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.29525680
24fibril organization (GO:0097435)4.22611499
25dermatan sulfate biosynthetic process (GO:0030208)4.21380239
26sequestering of extracellular ligand from receptor (GO:0035581)4.21302688
27protein complex biogenesis (GO:0070271)4.19417750
28translational initiation (GO:0006413)4.16327946
29epithelial cilium movement (GO:0003351)4.15426573
30mitochondrial respiratory chain complex I assembly (GO:0032981)4.12531607
31NADH dehydrogenase complex assembly (GO:0010257)4.12531607
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.12531607
33chondrocyte development (GO:0002063)3.94197412
34protein complex disassembly (GO:0043241)3.92993385
35mitochondrial respiratory chain complex assembly (GO:0033108)3.88173042
36dermatan sulfate metabolic process (GO:0030205)3.86026802
37collagen metabolic process (GO:0032963)3.77221273
38negative regulation of phagocytosis (GO:0050765)3.75507672
39protein targeting to membrane (GO:0006612)3.73906433
40protein neddylation (GO:0045116)3.68008672
41intraciliary transport (GO:0042073)3.65951756
42collagen catabolic process (GO:0030574)3.65865465
43macromolecular complex disassembly (GO:0032984)3.65813797
44maturation of SSU-rRNA (GO:0030490)3.59277726
45neuron fate determination (GO:0048664)3.57539824
46short-term memory (GO:0007614)3.56663203
47negative regulation of mast cell activation (GO:0033004)3.53957860
48cartilage condensation (GO:0001502)3.53880407
49cell aggregation (GO:0098743)3.53880407
50ribosomal large subunit biogenesis (GO:0042273)3.52924577
51translation (GO:0006412)3.52292148
52tongue development (GO:0043586)3.48596669
53multicellular organismal macromolecule metabolic process (GO:0044259)3.46712017
54endothelial cell morphogenesis (GO:0001886)3.44840704
55seminiferous tubule development (GO:0072520)3.44803187
56centriole replication (GO:0007099)3.41673345
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.38226166
58positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.37440947
59mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.35943635
60protein retention in ER lumen (GO:0006621)3.35488926
61nuclear-transcribed mRNA catabolic process (GO:0000956)3.34766821
62embryonic skeletal joint morphogenesis (GO:0060272)3.32025759
63endocardial cushion morphogenesis (GO:0003203)3.31632599
64multicellular organismal catabolic process (GO:0044243)3.30849479
65G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.28939395
66maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.26343115
67multicellular organismal metabolic process (GO:0044236)3.26118143
68basement membrane organization (GO:0071711)3.25226448
69GTP biosynthetic process (GO:0006183)3.23385294
70mesenchyme morphogenesis (GO:0072132)3.22635356
71pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.22517232
72RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.18889953
73tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.18889953
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.18860188
75mRNA catabolic process (GO:0006402)3.15147910
76positive regulation of cartilage development (GO:0061036)3.14957200
77negative regulation of chondrocyte differentiation (GO:0032331)3.14459887
78neuronal stem cell maintenance (GO:0097150)3.13210539
79mesenchymal cell proliferation (GO:0010463)3.12698442
80paraxial mesoderm development (GO:0048339)3.08678397
81cilium movement (GO:0003341)3.08643378
82respiratory electron transport chain (GO:0022904)3.07276573
83metanephric mesenchyme development (GO:0072075)3.06856264
84outer ear morphogenesis (GO:0042473)3.06673962
85cochlea morphogenesis (GO:0090103)3.05907663
86craniofacial suture morphogenesis (GO:0097094)3.05697078
87platelet dense granule organization (GO:0060155)3.04559308
88electron transport chain (GO:0022900)3.03565874
89radial glial cell differentiation (GO:0060019)3.03366023
90peptidyl-histidine modification (GO:0018202)3.02076138
91mannosylation (GO:0097502)3.01282047
92negative regulation of cartilage development (GO:0061037)3.01220832
93peptidyl-proline hydroxylation (GO:0019511)3.00287661
94neuron projection extension involved in neuron projection guidance (GO:1902284)2.98015217
95axon extension involved in axon guidance (GO:0048846)2.98015217
96glomerular basement membrane development (GO:0032836)2.97609413
97endodermal cell differentiation (GO:0035987)2.97405320
98lymphangiogenesis (GO:0001946)2.97337642
99kidney mesenchyme development (GO:0072074)2.96041218
100positive regulation of extracellular matrix organization (GO:1903055)2.95428657
101cilium morphogenesis (GO:0060271)2.93432577
102cell proliferation involved in kidney development (GO:0072111)2.93269340
103extracellular matrix disassembly (GO:0022617)2.93265465
104blood vessel maturation (GO:0001955)2.91600368
105cranial suture morphogenesis (GO:0060363)2.91352574
106negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.91012471
107base-excision repair, AP site formation (GO:0006285)2.90905158
108somite development (GO:0061053)2.89980787
109negative regulation of embryonic development (GO:0045992)2.88403790
110cardiac epithelial to mesenchymal transition (GO:0060317)2.88357833
111establishment of planar polarity (GO:0001736)2.86580220
112establishment of tissue polarity (GO:0007164)2.86580220
113cellular response to BMP stimulus (GO:0071773)2.85664094
114response to BMP (GO:0071772)2.85664094
115estrogen biosynthetic process (GO:0006703)2.85009358
116parturition (GO:0007567)2.84751173
117peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.83854395
118chondroitin sulfate biosynthetic process (GO:0030206)2.83327982
119extracellular regulation of signal transduction (GO:1900115)2.83005082
120extracellular negative regulation of signal transduction (GO:1900116)2.83005082
121positive regulation of epithelial to mesenchymal transition (GO:0010718)2.82796574
122peptidyl-proline modification (GO:0018208)2.81822246
123C-terminal protein lipidation (GO:0006501)2.81714574
124DNA deamination (GO:0045006)2.81544958
125preassembly of GPI anchor in ER membrane (GO:0016254)2.81475123
126kinetochore assembly (GO:0051382)2.80695516
127planar cell polarity pathway involved in neural tube closure (GO:0090179)2.80485754
128skin morphogenesis (GO:0043589)2.79779817
129extracellular matrix assembly (GO:0085029)2.79522377
130deoxyribonucleotide catabolic process (GO:0009264)2.79336059
131RNA catabolic process (GO:0006401)2.78977227
132extracellular matrix organization (GO:0030198)2.78247726
133cell proliferation involved in metanephros development (GO:0072203)2.77994018
134UTP metabolic process (GO:0046051)2.77929316
135pyrimidine nucleotide catabolic process (GO:0006244)2.77826556
136middle ear morphogenesis (GO:0042474)2.77631055
137limb bud formation (GO:0060174)2.76999874
138extracellular structure organization (GO:0043062)2.76959371
139protein peptidyl-prolyl isomerization (GO:0000413)2.75181107
140respiratory chain complex IV assembly (GO:0008535)2.73987372
141endothelial cell proliferation (GO:0001935)2.73948697
142cartilage development (GO:0051216)2.73317722
143negative regulation of striated muscle cell apoptotic process (GO:0010664)2.71447228
144cell migration involved in heart development (GO:0060973)2.70524983
145resolution of meiotic recombination intermediates (GO:0000712)2.69274896
146cullin deneddylation (GO:0010388)2.68624552
147artery development (GO:0060840)2.67998695
148epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.67694101
149regulation of non-canonical Wnt signaling pathway (GO:2000050)2.66807444
150UTP biosynthetic process (GO:0006228)2.66760897
151negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.66670395
152regulation of integrin-mediated signaling pathway (GO:2001044)2.64505541
153positive regulation of granulocyte differentiation (GO:0030854)2.63360401
154ventricular cardiac muscle cell development (GO:0055015)2.62885562
155SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.61414524
156positive regulation of stem cell differentiation (GO:2000738)2.60928382
157deoxyribose phosphate catabolic process (GO:0046386)2.60831900
158Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.60670371
159regulation of isotype switching to IgG isotypes (GO:0048302)2.60062973
160intracellular protein transmembrane import (GO:0044743)2.59931388
161purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.59423072
162regulation of heart morphogenesis (GO:2000826)2.57847879
163positive regulation of chondrocyte differentiation (GO:0032332)2.57676065
164C-terminal protein amino acid modification (GO:0018410)2.57450031
165epithelial to mesenchymal transition (GO:0001837)2.56502109
166cotranslational protein targeting to membrane (GO:0006613)2.56416341
167protein targeting to ER (GO:0045047)2.54283214
168sequestering of actin monomers (GO:0042989)2.53779824
169embryonic cranial skeleton morphogenesis (GO:0048701)2.53214279
170ubiquinone biosynthetic process (GO:0006744)2.53159913
171behavioral response to nicotine (GO:0035095)2.52757962
172wound healing, spreading of epidermal cells (GO:0035313)2.52429524
173non-canonical Wnt signaling pathway (GO:0035567)2.52338230
174purine nucleoside triphosphate biosynthetic process (GO:0009145)2.52318536
175limb development (GO:0060173)2.52081419
176appendage development (GO:0048736)2.52081419
177regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.51577489
178purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.51530591
179purine deoxyribonucleotide catabolic process (GO:0009155)2.50686502
180regulation of cartilage development (GO:0061035)2.50301400
181nucleotide-sugar biosynthetic process (GO:0009226)2.49907274
182deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.49790940
183viral transcription (GO:0019083)2.49128811
184head development (GO:0060322)2.48300308
185regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.47943903
186regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.47720175
187response to gravity (GO:0009629)2.47260792
188cytochrome complex assembly (GO:0017004)2.47033632
189regulation of metalloenzyme activity (GO:0048552)2.46352592
190protein deneddylation (GO:0000338)2.46105905
191protein targeting (GO:0006605)2.43939625
192kinetochore organization (GO:0051383)2.43050283
193negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.43040489
194kidney morphogenesis (GO:0060993)2.42965389
195dentate gyrus development (GO:0021542)2.42799938

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.71123844
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.30693067
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.81015308
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.46740197
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.22861980
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.08491212
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.90283440
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.84800157
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.79891809
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.68280165
11WT1_19549856_ChIP-ChIP_CCG9911_Human2.64454691
12CLOCK_20551151_ChIP-Seq_293T_Human2.52370736
13ZNF274_21170338_ChIP-Seq_K562_Hela2.44052967
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.43097101
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.41436006
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.37945337
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.30270176
18EWS_26573619_Chip-Seq_HEK293_Human2.27528121
19IGF1R_20145208_ChIP-Seq_DFB_Human2.22373494
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.18854039
21CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.11870078
22HIF1A_21447827_ChIP-Seq_MCF-7_Human2.10737713
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.07394006
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.07360964
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.06518466
26TP53_20018659_ChIP-ChIP_R1E_Mouse2.04637391
27TP63_19390658_ChIP-ChIP_HaCaT_Human2.03783581
28EZH2_22144423_ChIP-Seq_EOC_Human2.01895202
29TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.01064176
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00292711
31FUS_26573619_Chip-Seq_HEK293_Human2.00110750
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.96989484
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.95808845
34VDR_23849224_ChIP-Seq_CD4+_Human1.94173406
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.92496137
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.91875175
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91638442
38MYC_18940864_ChIP-ChIP_HL60_Human1.89408682
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88114835
40RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.87670067
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.78913731
42GBX2_23144817_ChIP-Seq_PC3_Human1.78579370
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77670913
44ELK1_22589737_ChIP-Seq_MCF10A_Human1.76473947
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.76158614
46CJUN_26792858_Chip-Seq_BT549_Human1.75269714
47FOXP3_21729870_ChIP-Seq_TREG_Human1.73787936
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.72989144
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.69314389
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.66557960
51IRF1_19129219_ChIP-ChIP_H3396_Human1.65627331
52SOX2_18555785_ChIP-Seq_MESCs_Mouse1.64087486
53KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.64067205
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.62947364
55P300_19829295_ChIP-Seq_ESCs_Human1.62843805
56TCF3_18692474_ChIP-Seq_MEFs_Mouse1.61801447
57MYC_18358816_ChIP-ChIP_MESCs_Mouse1.60862400
58MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.57801842
59ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.57554793
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.56898837
61HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.56562315
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.56358520
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.56307032
64NANOG_16153702_ChIP-ChIP_HESCs_Human1.55425203
65EP300_21415370_ChIP-Seq_HL-1_Mouse1.54667364
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54596199
67ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.53236472
68E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51039331
69RNF2_27304074_Chip-Seq_NSC_Mouse1.50402786
70* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49235485
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49234052
72NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47456207
73TAF15_26573619_Chip-Seq_HEK293_Human1.47263994
74BRD4_25478319_ChIP-Seq_HGPS_Human1.44935770
75SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.44369486
76EZH2_27304074_Chip-Seq_ESCs_Mouse1.44354267
77FLI1_27457419_Chip-Seq_LIVER_Mouse1.44272094
78AR_21909140_ChIP-Seq_LNCAP_Human1.43130566
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42985676
80ETS1_20019798_ChIP-Seq_JURKAT_Human1.42422007
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42095644
82ELK1_19687146_ChIP-ChIP_HELA_Human1.41280949
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.41026917
84E2F7_22180533_ChIP-Seq_HELA_Human1.40931542
85RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40808925
86SALL1_21062744_ChIP-ChIP_HESCs_Human1.40654526
87XRN2_22483619_ChIP-Seq_HELA_Human1.40355549
88SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.40345681
89BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38037869
90HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36186432
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35789727
92* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35648402
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35033279
94CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33953907
95NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.32955806
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32842097
97CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.32518745
98JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.30637997
99TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.28645175
100KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.25681139
101KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.25681139
102KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.25681139
103SMC3_22415368_ChIP-Seq_MEFs_Mouse1.24590850
104HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24089918
105TTF2_22483619_ChIP-Seq_HELA_Human1.24069630
106ESR1_21235772_ChIP-Seq_MCF-7_Human1.23809349
107SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.22824681
108SA1_22415368_ChIP-Seq_MEFs_Mouse1.20685250
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19641125
110CBP_20019798_ChIP-Seq_JUKART_Human1.19552013
111IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19552013
112VDR_22108803_ChIP-Seq_LS180_Human1.19054944
113E2F4_17652178_ChIP-ChIP_JURKAT_Human1.18167622
114CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.17871325
115EZH2_18974828_ChIP-Seq_MESCs_Mouse1.16922823
116RNF2_18974828_ChIP-Seq_MESCs_Mouse1.16922823
117STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16165877
118TP53_22573176_ChIP-Seq_HFKS_Human1.16024547
119POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14411502
120SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14075806
121SMC1_22415368_ChIP-Seq_MEFs_Mouse1.13778960
122PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13483818
123* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.13471914
124FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13104756
125HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12667150
126ERG_20517297_ChIP-Seq_VCAP_Human1.11731936
127ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11698415
128JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11485059
129PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09812255
130* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09407193
131SOX17_20123909_ChIP-Seq_XEN_Mouse1.08920780
132WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06466504
133AR_20517297_ChIP-Seq_VCAP_Human1.05427320
134* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05052325
135KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04256377
136NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04185238
137NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04185238
138CBX2_27304074_Chip-Seq_ESCs_Mouse1.03581022
139OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03337025
140* NANOG_19829295_ChIP-Seq_ESCs_Human1.03113288
141* SOX2_19829295_ChIP-Seq_ESCs_Human1.03113288
142PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03001626
143ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01740143
144TP53_18474530_ChIP-ChIP_U2OS_Human1.01143256
145GATA3_21878914_ChIP-Seq_MCF-7_Human1.00203187
146SOX2_16153702_ChIP-ChIP_HESCs_Human1.00005098
147FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.99994445
148YY1_21170310_ChIP-Seq_MESCs_Mouse0.99581891
149GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98959254
150CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97702714
151FOXA1_25329375_ChIP-Seq_VCAP_Human0.94867418
152FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94867418
153TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93079693
154KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90686769
155HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88245405
156JARID2_20064375_ChIP-Seq_MESCs_Mouse0.87710470
157UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86500196
158CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.85788425
159SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.85313275
160ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84236505
161BCAT_22108803_ChIP-Seq_LS180_Human0.83916824
162SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83530879
163NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82439810
164SMAD3_21741376_ChIP-Seq_EPCs_Human0.81905893
165* NANOG_20526341_ChIP-Seq_ESCs_Human0.80561114

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.18936763
2MP0005503_abnormal_tendon_morphology6.27250940
3MP0005275_abnormal_skin_tensile4.42817141
4MP0003279_aneurysm3.86055984
5MP0006292_abnormal_olfactory_placode3.72349166
6MP0002653_abnormal_ependyma_morphology3.22813106
7MP0010030_abnormal_orbit_morphology3.15423281
8MP0004272_abnormal_basement_membrane2.80587199
9MP0009384_cardiac_valve_regurgitation2.75026652
10MP0003705_abnormal_hypodermis_morpholog2.71232247
11MP0001958_emphysema2.70607896
12MP0002282_abnormal_trachea_morphology2.54783110
13MP0009250_abnormal_appendicular_skeleto2.48064567
14MP0005508_abnormal_skeleton_morphology2.44848437
15MP0001542_abnormal_bone_strength2.25330582
16MP0003385_abnormal_body_wall2.13113575
17MP0003787_abnormal_imprinting2.05973266
18MP0006072_abnormal_retinal_apoptosis2.00508549
19MP0002249_abnormal_larynx_morphology1.99749305
20MP0000049_abnormal_middle_ear1.97404164
21MP0010368_abnormal_lymphatic_system1.92502672
22MP0004142_abnormal_muscle_tone1.91338975
23MP0002163_abnormal_gland_morphology1.83726080
24MP0002108_abnormal_muscle_morphology1.82999052
25MP0006054_spinal_hemorrhage1.81215661
26MP0000372_irregular_coat_pigmentation1.80683977
27MP0002102_abnormal_ear_morphology1.74584309
28MP0004134_abnormal_chest_morphology1.73258190
29MP0008789_abnormal_olfactory_epithelium1.72896519
30MP0003123_paternal_imprinting1.71262398
31MP0003122_maternal_imprinting1.70087064
32MP0000163_abnormal_cartilage_morphology1.70062759
33MP0006276_abnormal_autonomic_nervous1.67455011
34MP0001293_anophthalmia1.67109273
35MP0003942_abnormal_urinary_system1.62731233
36MP0001986_abnormal_taste_sensitivity1.60480041
37MP0005257_abnormal_intraocular_pressure1.59113556
38MP0003880_abnormal_central_pattern1.57234797
39MP0001879_abnormal_lymphatic_vessel1.55980599
40MP0001529_abnormal_vocalization1.55652920
41MP0002295_abnormal_pulmonary_circulatio1.55449404
42MP0009053_abnormal_anal_canal1.54842383
43MP0005084_abnormal_gallbladder_morpholo1.52624263
44MP0005623_abnormal_meninges_morphology1.52043660
45MP0002933_joint_inflammation1.50615607
46MP0002060_abnormal_skin_morphology1.45560380
47MP0005253_abnormal_eye_physiology1.43716162
48MP0002115_abnormal_skeleton_extremities1.42774024
49MP0002932_abnormal_joint_morphology1.39493151
50MP0008877_abnormal_DNA_methylation1.39087238
51MP0000631_abnormal_neuroendocrine_gland1.38152479
52MP0003283_abnormal_digestive_organ1.37859613
53MP0005023_abnormal_wound_healing1.33981636
54MP0002938_white_spotting1.31828905
55MP0003755_abnormal_palate_morphology1.30360654
56MP0002638_abnormal_pupillary_reflex1.28944445
57MP0000534_abnormal_ureter_morphology1.28065646
58MP0002896_abnormal_bone_mineralization1.25932247
59MP0000762_abnormal_tongue_morphology1.24902899
60MP0002113_abnormal_skeleton_development1.24800654
61MP0003646_muscle_fatigue1.23651625
62MP0005390_skeleton_phenotype1.23295464
63MP0005367_renal/urinary_system_phenotyp1.21306518
64MP0000516_abnormal_urinary_system1.21306518
65MP0003566_abnormal_cell_adhesion1.20914578
66MP0005171_absent_coat_pigmentation1.20294657
67MP0002109_abnormal_limb_morphology1.20242360
68MP0003115_abnormal_respiratory_system1.20089588
69MP0008058_abnormal_DNA_repair1.18986542
70MP0000751_myopathy1.18827635
71MP0002751_abnormal_autonomic_nervous1.17599840
72MP0000750_abnormal_muscle_regeneration1.15822031
73MP0009379_abnormal_foot_pigmentation1.14416794
74MP0002116_abnormal_craniofacial_bone1.13892125
75MP0005394_taste/olfaction_phenotype1.13224658
76MP0005499_abnormal_olfactory_system1.13224658
77MP0000749_muscle_degeneration1.12600479
78MP0003937_abnormal_limbs/digits/tail_de1.09933527
79MP0005391_vision/eye_phenotype1.09702692
80MP0000778_abnormal_nervous_system1.08960738
81MP0000767_abnormal_smooth_muscle1.08246828
82MP0008995_early_reproductive_senescence1.07911104
83MP0002009_preneoplasia1.06443601
84MP0002234_abnormal_pharynx_morphology1.06398718
85MP0000026_abnormal_inner_ear1.06060058
86MP0005551_abnormal_eye_electrophysiolog1.06006923
87MP0002233_abnormal_nose_morphology1.04506944
88MP0004133_heterotaxia1.04378489
89MP0000432_abnormal_head_morphology1.03916567
90MP0001485_abnormal_pinna_reflex1.03855459
91MP0002111_abnormal_tail_morphology1.02276898
92MP0001243_abnormal_dermal_layer1.01640655
93MP0000428_abnormal_craniofacial_morphol1.01467344
94MP0003935_abnormal_craniofacial_develop0.98914329
95MP0004084_abnormal_cardiac_muscle0.98669878
96MP0002837_dystrophic_cardiac_calcinosis0.97951758
97MP0003186_abnormal_redox_activity0.97926926
98MP0002114_abnormal_axial_skeleton0.97390354
99MP0004145_abnormal_muscle_electrophysio0.95563315
100MP0003786_premature_aging0.94067936
101MP0003941_abnormal_skin_development0.93904425
102MP0008007_abnormal_cellular_replicative0.93066367
103MP0002928_abnormal_bile_duct0.93024612
104MP0005645_abnormal_hypothalamus_physiol0.92945150
105MP0003195_calcinosis0.92474116
106MP0000013_abnormal_adipose_tissue0.90627872
107MP0001299_abnormal_eye_distance/0.90399948
108MP0001963_abnormal_hearing_physiology0.89874661
109MP0005195_abnormal_posterior_eye0.88724380
110MP0002127_abnormal_cardiovascular_syste0.88678806
111MP0003121_genomic_imprinting0.88613528
112MP0003878_abnormal_ear_physiology0.88605073
113MP0005377_hearing/vestibular/ear_phenot0.88605073
114MP0005595_abnormal_vascular_smooth0.87880595
115MP0005389_reproductive_system_phenotype0.86331659
116MP0004147_increased_porphyrin_level0.86069892
117MP0002752_abnormal_somatic_nervous0.84833882
118MP0002089_abnormal_postnatal_growth/wei0.83882913
119MP0001270_distended_abdomen0.82129437
120MP0001905_abnormal_dopamine_level0.80744346
121MP0003315_abnormal_perineum_morphology0.80559322
122MP0001119_abnormal_female_reproductive0.80456631
123MP0001175_abnormal_lung_morphology0.78581981
124MP0002128_abnormal_blood_circulation0.78520274
125MP0003011_delayed_dark_adaptation0.78098906
126MP0006138_congestive_heart_failure0.76318412
127MP0001984_abnormal_olfaction0.75656501
128MP0001286_abnormal_eye_development0.75532388
129MP0002160_abnormal_reproductive_system0.75515025
130MP0002166_altered_tumor_susceptibility0.74675476
131MP0008932_abnormal_embryonic_tissue0.74662010
132MP0002736_abnormal_nociception_after0.74293485
133MP0004883_abnormal_blood_vessel0.73610868
134MP0003950_abnormal_plasma_membrane0.73001776
135MP0000537_abnormal_urethra_morphology0.72475742
136MP0000759_abnormal_skeletal_muscle0.71958082
137MP0005388_respiratory_system_phenotype0.71369281
138MP0002133_abnormal_respiratory_system0.71369281
139MP0004197_abnormal_fetal_growth/weight/0.71142470
140MP0006036_abnormal_mitochondrial_physio0.70734003
141MP0000566_synostosis0.70698890
142MP0008775_abnormal_heart_ventricle0.70600444
143MP0003119_abnormal_digestive_system0.69476341
144MP0005379_endocrine/exocrine_gland_phen0.69361036
145MP0004233_abnormal_muscle_weight0.68440108
146MP0005369_muscle_phenotype0.67191267
147MP0001614_abnormal_blood_vessel0.65938805
148MP0003795_abnormal_bone_structure0.65590506
149MP0003567_abnormal_fetal_cardiomyocyte0.65175235
150MP0002177_abnormal_outer_ear0.64387291
151MP0000733_abnormal_muscle_development0.63876542
152MP0004858_abnormal_nervous_system0.62457603
153MP0003091_abnormal_cell_migration0.61720414
154MP0002972_abnormal_cardiac_muscle0.59857649
155MP0003136_yellow_coat_color0.58641974

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.23270324
2Premature rupture of membranes (HP:0001788)6.02794166
3Neonatal short-limb short stature (HP:0008921)4.58114974
4Abnormality of dentin (HP:0010299)4.50604894
5Type 2 muscle fiber atrophy (HP:0003554)4.37027397
6Soft skin (HP:0000977)4.25033974
7Biconcave vertebral bodies (HP:0004586)3.95875159
8Muscle fiber atrophy (HP:0100295)3.88261912
9Acute necrotizing encephalopathy (HP:0006965)3.87614154
10Irregular epiphyses (HP:0010582)3.70812775
11Reticulocytopenia (HP:0001896)3.66687142
12Molar tooth sign on MRI (HP:0002419)3.65583026
13Abnormality of midbrain morphology (HP:0002418)3.65583026
14Pancreatic cysts (HP:0001737)3.65209300
15Epiphyseal dysplasia (HP:0002656)3.59960926
163-Methylglutaconic aciduria (HP:0003535)3.58634776
17Abnormal mitochondria in muscle tissue (HP:0008316)3.47295312
18Pancreatic fibrosis (HP:0100732)3.45104820
19Acute encephalopathy (HP:0006846)3.43811672
20Nephronophthisis (HP:0000090)3.41334919
21Bladder diverticulum (HP:0000015)3.39204269
22Aortic dissection (HP:0002647)3.38333784
23Wormian bones (HP:0002645)3.37384256
24Mitochondrial inheritance (HP:0001427)3.28343728
25Aortic aneurysm (HP:0004942)3.19963505
26Vertebral compression fractures (HP:0002953)3.19184694
27Progressive macrocephaly (HP:0004481)3.19075423
28Vitreoretinal degeneration (HP:0000655)3.18297116
29Spinal rigidity (HP:0003306)3.13027206
30Abnormality of cells of the erythroid lineage (HP:0012130)3.11363816
31Bile duct proliferation (HP:0001408)3.07771396
32Abnormal biliary tract physiology (HP:0012439)3.07771396
33Ankle contracture (HP:0006466)3.07661597
34True hermaphroditism (HP:0010459)3.03937975
35Mild short stature (HP:0003502)3.03610947
36Blue sclerae (HP:0000592)2.94738093
37Follicular hyperkeratosis (HP:0007502)2.89167738
38Colon cancer (HP:0003003)2.85980735
39Distal arthrogryposis (HP:0005684)2.85513959
40Type 1 muscle fiber predominance (HP:0003803)2.80949235
41Abnormal number of erythroid precursors (HP:0012131)2.79150447
42Increased CSF lactate (HP:0002490)2.78740445
43Shallow orbits (HP:0000586)2.77875095
44Atrophic scars (HP:0001075)2.77651256
45Vascular tortuosity (HP:0004948)2.76244121
46Hypoplastic ischia (HP:0003175)2.69856448
47Abnormality of the renal medulla (HP:0100957)2.68030306
48Small epiphyses (HP:0010585)2.67424329
49Broad metatarsal (HP:0001783)2.66872714
50Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.66249387
51Cervical subluxation (HP:0003308)2.65025728
52Medial flaring of the eyebrow (HP:0010747)2.62654803
53Cupped ribs (HP:0000887)2.62376372
54Septo-optic dysplasia (HP:0100842)2.60153888
55Rib fusion (HP:0000902)2.58300258
56Abnormality of the diencephalon (HP:0010662)2.57739619
57Osteoarthritis (HP:0002758)2.57646614
58Macrocytic anemia (HP:0001972)2.57328869
59Increased hepatocellular lipid droplets (HP:0006565)2.57272269
60Cystic liver disease (HP:0006706)2.56429913
61Morphological abnormality of the middle ear (HP:0008609)2.55561674
62Beaking of vertebral bodies (HP:0004568)2.54630607
63Wide anterior fontanel (HP:0000260)2.54076274
64Coxa vara (HP:0002812)2.51044215
65Abnormality of the acetabulum (HP:0003170)2.45218312
66Overgrowth (HP:0001548)2.43849625
67Flat capital femoral epiphysis (HP:0003370)2.42615229
68Anophthalmia (HP:0000528)2.41584647
69Platyspondyly (HP:0000926)2.37919170
70Hepatocellular necrosis (HP:0001404)2.37864490
71Fragile skin (HP:0001030)2.36904600
72Dilatation of the ascending aorta (HP:0005111)2.36485457
73Chronic hepatic failure (HP:0100626)2.36407691
74Genu recurvatum (HP:0002816)2.35202151
75Lipid accumulation in hepatocytes (HP:0006561)2.34288034
76Abnormality of the ischium (HP:0003174)2.33144806
77Renal Fanconi syndrome (HP:0001994)2.28062922
78Weak cry (HP:0001612)2.26403502
79Peritonitis (HP:0002586)2.25133858
80Broad long bones (HP:0005622)2.23878867
81Genu varum (HP:0002970)2.19725868
82Cerebral edema (HP:0002181)2.19173657
83Increased connective tissue (HP:0009025)2.18471168
84Abnormal delivery (HP:0001787)2.18012383
85Hepatic necrosis (HP:0002605)2.15406379
86Bifid tongue (HP:0010297)2.14094474
87Congenital hepatic fibrosis (HP:0002612)2.12134398
88Pulmonary artery stenosis (HP:0004415)2.11882756
89Broad ribs (HP:0000885)2.11329506
90Mesomelia (HP:0003027)2.09714047
91Hyperextensible skin (HP:0000974)2.08877864
92Ulnar deviation of the wrist (HP:0003049)2.08442937
93Decreased skull ossification (HP:0004331)2.07776987
94Abnormal drinking behavior (HP:0030082)2.07451040
95Polydipsia (HP:0001959)2.07451040
96Delayed epiphyseal ossification (HP:0002663)2.07399492
97Tubular atrophy (HP:0000092)2.07311152
98Arterial tortuosity (HP:0005116)2.06906388
99Absent phalangeal crease (HP:0006109)2.03522512
100Abnormal tarsal ossification (HP:0008369)2.01930220
101Pallor (HP:0000980)1.99277027
102Metaphyseal dysplasia (HP:0100255)1.98882949
103Short middle phalanx of the 5th finger (HP:0004220)1.98797092
104Adrenal hypoplasia (HP:0000835)1.98577533
105Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.98446331
106Congenital primary aphakia (HP:0007707)1.96871901
107Nonimmune hydrops fetalis (HP:0001790)1.96462152
108Optic disc pallor (HP:0000543)1.95841903
109Slender build (HP:0001533)1.95320739
110Bell-shaped thorax (HP:0001591)1.95262993
111Patent foramen ovale (HP:0001655)1.94954241
112Joint laxity (HP:0001388)1.94737503
113Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.94310557
114Abnormality of the phalanges of the 2nd finger (HP:0009541)1.93752144
115Symphalangism affecting the phalanges of the hand (HP:0009773)1.93684510
116Hypoplasia of the ulna (HP:0003022)1.93312785
117Depressed nasal ridge (HP:0000457)1.93137360
118Metaphyseal cupping (HP:0003021)1.93064681
119Breech presentation (HP:0001623)1.92981231
120Growth hormone deficiency (HP:0000824)1.92793419
121Limited hip movement (HP:0008800)1.92732375
122Mitral valve prolapse (HP:0001634)1.91852402
123Hip contracture (HP:0003273)1.91586224
124Abnormality of the neuromuscular junction (HP:0003398)1.91305984
125Fatigable weakness (HP:0003473)1.91305984
126Intestinal atresia (HP:0011100)1.91226435
127Congenital stationary night blindness (HP:0007642)1.91191034
128Postaxial hand polydactyly (HP:0001162)1.90658838
129Sclerocornea (HP:0000647)1.90417370
130Polyuria (HP:0000103)1.89662566
131Tubulointerstitial abnormality (HP:0001969)1.89385553
132Mildly elevated creatine phosphokinase (HP:0008180)1.88907838
133Hyperglycinemia (HP:0002154)1.88662883
134Elbow flexion contracture (HP:0002987)1.88645356
135Stenosis of the external auditory canal (HP:0000402)1.87984133
136Increased corneal curvature (HP:0100692)1.87325138
137Keratoconus (HP:0000563)1.87325138
138Delayed cranial suture closure (HP:0000270)1.87003529
139Tubulointerstitial nephritis (HP:0001970)1.86790996
140Decreased muscle mass (HP:0003199)1.85814030
141Broad phalanx (HP:0006009)1.85219952
142Postaxial foot polydactyly (HP:0001830)1.85001755
143Nephrogenic diabetes insipidus (HP:0009806)1.84607090
144Calcaneovalgus deformity (HP:0001848)1.83599379
145Abnormality of the proximal phalanges of the hand (HP:0009834)1.83290829
146Aplasia/Hypoplasia of the tongue (HP:0010295)1.82475120
147Exertional dyspnea (HP:0002875)1.82433823
148Gait imbalance (HP:0002141)1.82346512
149Panhypogammaglobulinemia (HP:0003139)1.81935527
150Increased variability in muscle fiber diameter (HP:0003557)1.81745107
151Diastasis recti (HP:0001540)1.81275952
152Hypoplastic pelvis (HP:0008839)1.80481754
153Short hallux (HP:0010109)1.80421772
154Bowel diverticulosis (HP:0005222)1.79684492
155Exercise intolerance (HP:0003546)1.79562077
156Wrist flexion contracture (HP:0001239)1.79488660
157Abolished electroretinogram (ERG) (HP:0000550)1.78915557
158Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.78649135
159Absent epiphyses (HP:0010577)1.78649135
160Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.78188995
161Severe combined immunodeficiency (HP:0004430)1.78065564
162Abnormality of the renal cortex (HP:0011035)1.78032657
163Abnormality of skull ossification (HP:0002703)1.77422182
164Abnormality of the phalanges of the 5th finger (HP:0004213)1.77073292
165Cerebral aneurysm (HP:0004944)1.76391208
166Redundant skin (HP:0001582)1.76304157
167Triphalangeal thumb (HP:0001199)1.76287070
168Popliteal pterygium (HP:0009756)1.76195361
169Vaginal atresia (HP:0000148)1.75148369
170Fibular hypoplasia (HP:0003038)1.74477123
171Mitral regurgitation (HP:0001653)1.74152043
172Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.73707963
173Abnormality of femoral epiphyses (HP:0006499)1.73707963
174Increased serum lactate (HP:0002151)1.73584767
175Absent septum pellucidum (HP:0001331)1.72551351
176Tarsal synostosis (HP:0008368)1.72313618
177Deformed tarsal bones (HP:0008119)1.71697497
178Abnormality of the calcaneus (HP:0008364)1.71209054
179Flattened epiphyses (HP:0003071)1.71204508
180Joint stiffness (HP:0001387)1.70646104
181Asymmetry of the thorax (HP:0001555)1.70249936
182Abnormality of carpal bone ossification (HP:0006257)1.70171536
183Abnormality of the pubic bones (HP:0003172)1.69850859
184Genital tract atresia (HP:0001827)1.69745315
185Carpal bone hypoplasia (HP:0001498)1.69636108
186Abnormal finger flexion creases (HP:0006143)1.68753258
187Thoracolumbar scoliosis (HP:0002944)1.68273627
188Abnormality of renal resorption (HP:0011038)1.66565671
189Lactic acidosis (HP:0003128)1.66211748
190Thyroiditis (HP:0100646)1.66178266
191Partial duplication of the phalanx of hand (HP:0009999)1.64092357

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.01754998
2LATS23.75763572
3STK38L3.71094429
4VRK23.56130010
5LIMK13.26555959
6NME22.95638794
7WNK32.87022935
8EPHB22.79534503
9MYLK2.59225300
10BUB12.53008188
11CDK192.34498184
12MKNK12.21235499
13MAP4K22.21021285
14ERBB32.15692655
15TESK12.11057970
16STK242.09316788
17MAP3K31.94374617
18PIM21.91375429
19KIT1.89031949
20ADRBK21.87703629
21TRIB31.84627108
22MKNK21.82367458
23PASK1.75262257
24PIK3CA1.69466651
25TGFBR11.67520212
26MAPK151.64478475
27MUSK1.61009488
28ILK1.59315716
29TNIK1.57808550
30PLK21.53545244
31MAP4K11.50873381
32LATS11.48654845
33ZAK1.48475173
34EPHA31.48259549
35ROCK11.35026172
36TRPM71.33916868
37PDGFRA1.33686453
38WEE11.33558339
39FRK1.31984565
40PAK21.31216172
41EIF2AK11.26630728
42PLK31.25958146
43NEK11.23732996
44TLK11.22867421
45TESK21.22791981
46TTN1.20327523
47TEC1.19033059
48GRK11.18381702
49INSRR1.11579710
50KDR1.10943342
51TAOK31.10491113
52DYRK21.10391830
53SRPK11.09800339
54MAP3K41.06886085
55BRSK21.06655349
56OBSCN1.06238261
57CDC71.05282503
58TAF11.03356341
59CDK81.01565325
60TAOK21.00607205
61EIF2AK31.00506726
62TIE10.97980430
63PINK10.97597959
64CDC42BPA0.97492233
65PTK2B0.94739241
66TXK0.94219659
67NME10.94096629
68STK30.91712792
69TRIM280.90719539
70PRKG20.89693444
71LRRK20.89203404
72CDK70.89026107
73NLK0.88847724
74PAK40.87744812
75DYRK1B0.87558332
76DYRK30.86561190
77FES0.85229697
78PAK10.84964150
79PRPF4B0.82990937
80PIK3CG0.81592788
81FGFR20.81348887
82ITK0.80819036
83FER0.79368463
84ARAF0.77433123
85VRK10.77257309
86PAK30.75244608
87RPS6KA40.74890419
88PBK0.72810438
89PKN20.72779807
90STK160.72659450
91PTK20.71388005
92DAPK30.71281708
93PRKCG0.69416077
94AURKB0.69364773
95MET0.68544429
96EPHA40.67924349
97PLK10.66333440
98MAPK130.66058819
99PRKCQ0.65893222
100BTK0.65062776
101ROCK20.64023587
102ERN10.63742425
103ADRBK10.63593783
104AURKA0.63277070
105PNCK0.62585519
106CSF1R0.62377913
107DMPK0.62059516
108BRAF0.60007436
109PRKD30.59612518
110AKT30.58242747
111MAP2K30.58143064
112FGFR10.56143512
113OXSR10.55458410
114UHMK10.55038040
115ABL20.53398885
116EIF2AK20.52398624
117TNK20.52032552
118NEK20.51219816
119BCKDK0.50568305
120BRD40.50311548
121BCR0.50178481
122CSNK1G10.50053630
123PLK40.49875718
124CSNK1G30.49313795
125MAPK120.47785062
126CSNK1G20.47379787
127TGFBR20.46675623
128FLT30.46313971
129MAP3K100.46257287
130CDK140.45942614
131CSNK2A20.45755988
132MST40.45182199
133RPS6KA50.44150763
134PHKG20.43539213
135PHKG10.43539213
136BRSK10.43207697
137MOS0.43161937
138WNK40.40721984
139ATR0.40387682
140MAPKAPK30.40300974
141CSNK2A10.39586796
142PRKACA0.39527850
143MAP3K110.38932135
144NUAK10.38825512
145PRKCI0.37829533
146PRKCE0.37802503
147SYK0.37185917
148NEK60.36255900
149LYN0.36172588
150BMPR1B0.35934564
151LCK0.35624291
152IKBKE0.35607140
153PRKG10.35523401
154CDK11A0.34867690
155CDK180.34798606
156MAP2K70.33981019
157CASK0.33809493
158CHEK20.33207384
159CAMKK20.30679835
160STK40.29648165

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.85375663
2Ribosome_Homo sapiens_hsa030103.59939927
3Protein export_Homo sapiens_hsa030603.22932000
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.22666520
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.99958683
6Proteasome_Homo sapiens_hsa030502.74404684
7Protein digestion and absorption_Homo sapiens_hsa049742.67912914
8TGF-beta signaling pathway_Homo sapiens_hsa043502.54652085
9Basal cell carcinoma_Homo sapiens_hsa052172.52095313
10RNA polymerase_Homo sapiens_hsa030202.51151898
11Hedgehog signaling pathway_Homo sapiens_hsa043402.35409642
12Focal adhesion_Homo sapiens_hsa045102.20742411
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.07096747
14Hippo signaling pathway_Homo sapiens_hsa043902.00972414
15Parkinsons disease_Homo sapiens_hsa050121.94731742
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.92581847
17Fatty acid elongation_Homo sapiens_hsa000621.82092736
18Oxidative phosphorylation_Homo sapiens_hsa001901.77733909
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.72347595
20Huntingtons disease_Homo sapiens_hsa050161.68545878
21Asthma_Homo sapiens_hsa053101.68113451
22Dilated cardiomyopathy_Homo sapiens_hsa054141.67130414
23Primary immunodeficiency_Homo sapiens_hsa053401.66768098
24Propanoate metabolism_Homo sapiens_hsa006401.65423378
25Cell cycle_Homo sapiens_hsa041101.65099860
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.65048891
27Spliceosome_Homo sapiens_hsa030401.64567167
28DNA replication_Homo sapiens_hsa030301.62790529
29Pyrimidine metabolism_Homo sapiens_hsa002401.59676894
30Malaria_Homo sapiens_hsa051441.58733890
31Cardiac muscle contraction_Homo sapiens_hsa042601.51674190
32Nucleotide excision repair_Homo sapiens_hsa034201.50907658
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50197898
34PI3K-Akt signaling pathway_Homo sapiens_hsa041511.49682961
35Proteoglycans in cancer_Homo sapiens_hsa052051.42921749
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42833057
37RNA transport_Homo sapiens_hsa030131.38443051
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38209747
39Mismatch repair_Homo sapiens_hsa034301.35264177
40Base excision repair_Homo sapiens_hsa034101.33796245
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.31814859
42Butanoate metabolism_Homo sapiens_hsa006501.30213459
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.22437640
44Wnt signaling pathway_Homo sapiens_hsa043101.19777148
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.18659148
46Adherens junction_Homo sapiens_hsa045201.17095664
47Phototransduction_Homo sapiens_hsa047441.14737674
48Allograft rejection_Homo sapiens_hsa053301.14584802
49Autoimmune thyroid disease_Homo sapiens_hsa053201.14214792
50Alzheimers disease_Homo sapiens_hsa050101.11361125
51p53 signaling pathway_Homo sapiens_hsa041151.09502721
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09047806
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08214021
54MicroRNAs in cancer_Homo sapiens_hsa052061.01718067
55Peroxisome_Homo sapiens_hsa041461.01442102
56Homologous recombination_Homo sapiens_hsa034401.00779911
57Sulfur relay system_Homo sapiens_hsa041221.00433859
58Melanoma_Homo sapiens_hsa052180.97875297
59Purine metabolism_Homo sapiens_hsa002300.94339595
60Bladder cancer_Homo sapiens_hsa052190.93131900
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91794817
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89539163
63Tight junction_Homo sapiens_hsa045300.88816551
64Melanogenesis_Homo sapiens_hsa049160.87056729
65* Glutathione metabolism_Homo sapiens_hsa004800.87018495
66Basal transcription factors_Homo sapiens_hsa030220.85411529
67Small cell lung cancer_Homo sapiens_hsa052220.83939982
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83613904
69HTLV-I infection_Homo sapiens_hsa051660.83043855
70Pathways in cancer_Homo sapiens_hsa052000.82608453
71Linoleic acid metabolism_Homo sapiens_hsa005910.82544682
72N-Glycan biosynthesis_Homo sapiens_hsa005100.81017954
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79739406
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.78965851
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.76778062
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76089968
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75809123
78Selenocompound metabolism_Homo sapiens_hsa004500.75493653
79Hematopoietic cell lineage_Homo sapiens_hsa046400.75290039
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75034580
81* Arachidonic acid metabolism_Homo sapiens_hsa005900.74917612
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74125983
83Axon guidance_Homo sapiens_hsa043600.73748877
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.73483472
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72582889
86Nitrogen metabolism_Homo sapiens_hsa009100.71866535
87One carbon pool by folate_Homo sapiens_hsa006700.70832698
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70436688
89Galactose metabolism_Homo sapiens_hsa000520.70391381
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67368795
91Tryptophan metabolism_Homo sapiens_hsa003800.65860769
92Prostate cancer_Homo sapiens_hsa052150.65671589
93Amoebiasis_Homo sapiens_hsa051460.64320968
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62486851
95Viral myocarditis_Homo sapiens_hsa054160.61947788
96Regulation of autophagy_Homo sapiens_hsa041400.61574190
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59363966
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57514937
99Sulfur metabolism_Homo sapiens_hsa009200.57345221
100RNA degradation_Homo sapiens_hsa030180.54771181
101Arginine and proline metabolism_Homo sapiens_hsa003300.54352602
102Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53516271
103Thyroid cancer_Homo sapiens_hsa052160.52521661
104Epstein-Barr virus infection_Homo sapiens_hsa051690.50938685
105Folate biosynthesis_Homo sapiens_hsa007900.50720217
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.50272160
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49345219
108Fatty acid degradation_Homo sapiens_hsa000710.47509220
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47374321
110Fanconi anemia pathway_Homo sapiens_hsa034600.47045067
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45944236
112Steroid biosynthesis_Homo sapiens_hsa001000.45837367
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44137234
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43356139
115Sphingolipid metabolism_Homo sapiens_hsa006000.43351589
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43322104
117Rap1 signaling pathway_Homo sapiens_hsa040150.42978548
118Olfactory transduction_Homo sapiens_hsa047400.42717150
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42527911
120mRNA surveillance pathway_Homo sapiens_hsa030150.42107766
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39821215
122Pyruvate metabolism_Homo sapiens_hsa006200.37840211
123HIF-1 signaling pathway_Homo sapiens_hsa040660.37745377
124Ovarian steroidogenesis_Homo sapiens_hsa049130.37592506
125Gap junction_Homo sapiens_hsa045400.33715336
126Glycosaminoglycan degradation_Homo sapiens_hsa005310.32183072
127Shigellosis_Homo sapiens_hsa051310.31620176
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31557908
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.31228477
130Ether lipid metabolism_Homo sapiens_hsa005650.30656537
131Oocyte meiosis_Homo sapiens_hsa041140.30648623
132Non-homologous end-joining_Homo sapiens_hsa034500.30226755
133Cysteine and methionine metabolism_Homo sapiens_hsa002700.29709403
134Fatty acid metabolism_Homo sapiens_hsa012120.28826238
135Vibrio cholerae infection_Homo sapiens_hsa051100.28548408
136Type I diabetes mellitus_Homo sapiens_hsa049400.28285046
137Metabolic pathways_Homo sapiens_hsa011000.26654527
1382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.25902870
139Systemic lupus erythematosus_Homo sapiens_hsa053220.25454728
140* Thyroid hormone synthesis_Homo sapiens_hsa049180.24226821
141Carbon metabolism_Homo sapiens_hsa012000.22824575
142Caffeine metabolism_Homo sapiens_hsa002320.22113679
143Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.21950367
144Chemical carcinogenesis_Homo sapiens_hsa052040.21531448
145Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.19409980
146SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19026370
147Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.18618045
148Phagosome_Homo sapiens_hsa041450.17989281

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