GPX6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. Expression of this gene has been observed in embryos and olfactory epithelium; however, the exact function of this gene is not known. This isozyme is a selenoprotein in humans, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The orthologs of this gene in mouse and rat (and some other species) contain a cysteine (Cys) residue in place of the Sec residue, and their corresponding mRNAs lack the SECIS elements. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to cilium (GO:0061512)6.96604358
2one-carbon compound transport (GO:0019755)6.70918025
3ethanol oxidation (GO:0006069)5.60554680
4positive regulation of digestive system process (GO:0060456)5.40524030
5renal absorption (GO:0070293)5.36874779
6regulation of cholesterol biosynthetic process (GO:0045540)4.88411787
7platelet dense granule organization (GO:0060155)4.77640053
8exogenous drug catabolic process (GO:0042738)4.71912200
9cellular ketone body metabolic process (GO:0046950)4.59492614
10uronic acid metabolic process (GO:0006063)4.51287041
11glucuronate metabolic process (GO:0019585)4.51287041
12drug catabolic process (GO:0042737)4.49378460
13cellular glucuronidation (GO:0052695)4.48642741
14protein K11-linked deubiquitination (GO:0035871)4.45423168
15epoxygenase P450 pathway (GO:0019373)4.37179727
16antibacterial humoral response (GO:0019731)4.34133083
17respiratory chain complex IV assembly (GO:0008535)4.31367468
18ethanol metabolic process (GO:0006067)4.18588944
19ketone body metabolic process (GO:1902224)4.13729634
20polyol transport (GO:0015791)4.09838761
21reflex (GO:0060004)4.08860988
22tryptophan catabolic process (GO:0006569)4.08090763
23indole-containing compound catabolic process (GO:0042436)4.08090763
24indolalkylamine catabolic process (GO:0046218)4.08090763
25tachykinin receptor signaling pathway (GO:0007217)4.00231253
26antimicrobial humoral response (GO:0019730)3.99858979
27behavioral response to nicotine (GO:0035095)3.97388445
28excretion (GO:0007588)3.95651053
29lateral ventricle development (GO:0021670)3.90814081
30flavonoid metabolic process (GO:0009812)3.89659303
31detection of light stimulus involved in visual perception (GO:0050908)3.86617887
32detection of light stimulus involved in sensory perception (GO:0050962)3.86617887
33righting reflex (GO:0060013)3.85796352
34cytochrome complex assembly (GO:0017004)3.84589817
35regulation of sodium ion transmembrane transport (GO:1902305)3.80472834
36response to pheromone (GO:0019236)3.78344276
37response to mercury ion (GO:0046689)3.75058973
38adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.71170981
39detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.68386572
40regulation of glucokinase activity (GO:0033131)3.66556007
41regulation of hexokinase activity (GO:1903299)3.66556007
42cullin deneddylation (GO:0010388)3.62835891
43water transport (GO:0006833)3.61131128
44V(D)J recombination (GO:0033151)3.58732497
45gas transport (GO:0015669)3.55856782
46activation of protein kinase A activity (GO:0034199)3.53389523
47DNA deamination (GO:0045006)3.48909445
48auditory receptor cell differentiation (GO:0042491)3.47227496
49sulfur amino acid catabolic process (GO:0000098)3.45026743
50auditory receptor cell stereocilium organization (GO:0060088)3.43998924
51membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.43243690
52protein complex biogenesis (GO:0070271)3.42876051
53regulation of sodium ion transmembrane transporter activity (GO:2000649)3.42765602
54water-soluble vitamin biosynthetic process (GO:0042364)3.39706908
55indolalkylamine metabolic process (GO:0006586)3.39653698
56adaptation of signaling pathway (GO:0023058)3.38434315
57protein-chromophore linkage (GO:0018298)3.37391043
58regulation of cholesterol metabolic process (GO:0090181)3.36235197
59regulation of steroid hormone biosynthetic process (GO:0090030)3.36165693
60relaxation of cardiac muscle (GO:0055119)3.32761985
61tryptophan metabolic process (GO:0006568)3.30750110
62hormone catabolic process (GO:0042447)3.30130013
63carnitine metabolic process (GO:0009437)3.27468554
64L-ascorbic acid metabolic process (GO:0019852)3.26784564
65drug transmembrane transport (GO:0006855)3.26059036
66nonmotile primary cilium assembly (GO:0035058)3.24850181
67lysine catabolic process (GO:0006554)3.23526425
68lysine metabolic process (GO:0006553)3.23526425
69regulation of sodium ion transport (GO:0002028)3.18769796
70fluid transport (GO:0042044)3.15499760
71short-chain fatty acid metabolic process (GO:0046459)3.15392447
72photoreceptor cell maintenance (GO:0045494)3.14553085
73protein deneddylation (GO:0000338)3.13209972
74cysteine metabolic process (GO:0006534)3.12736436
75cellular potassium ion homeostasis (GO:0030007)3.11063750
76protein polyglutamylation (GO:0018095)3.10515753
77positive regulation of hormone biosynthetic process (GO:0046886)3.10187544
78kynurenine metabolic process (GO:0070189)3.10178557
79neuron fate determination (GO:0048664)3.10085269
80protein insertion into membrane (GO:0051205)3.09489895
81regulation of female gonad development (GO:2000194)3.09068775
82synaptic transmission, cholinergic (GO:0007271)3.04067303
83mating behavior (GO:0007617)3.01885929
84alkaloid metabolic process (GO:0009820)3.01634819
85chemical homeostasis within a tissue (GO:0048875)3.01058785
86peptide biosynthetic process (GO:0043043)3.00113499
87sensory perception of smell (GO:0007608)21.9497124
88mitochondrial respiratory chain complex assembly (GO:0033108)2.98448996
89membrane repolarization during action potential (GO:0086011)2.98185931
90negative regulation of systemic arterial blood pressure (GO:0003085)2.96854246
91behavioral response to ethanol (GO:0048149)2.96451325
92amino-acid betaine metabolic process (GO:0006577)2.94479579
93GPI anchor metabolic process (GO:0006505)2.93339070
94negative regulation of thymocyte apoptotic process (GO:0070244)2.90008648
95gamma-aminobutyric acid transport (GO:0015812)2.89336538
96negative regulation of mast cell activation (GO:0033004)2.87918234
97response to vitamin A (GO:0033189)2.86832600
98nonribosomal peptide biosynthetic process (GO:0019184)2.85792951
99regulation of neurotransmitter uptake (GO:0051580)2.84240389
100drug transport (GO:0015893)2.83466363
101protein targeting to Golgi (GO:0000042)2.81727207
102camera-type eye morphogenesis (GO:0048593)2.81381192
103cellular biogenic amine catabolic process (GO:0042402)2.81240719
104amine catabolic process (GO:0009310)2.81240719
105establishment of protein localization to Golgi (GO:0072600)2.80832608
106GPI anchor biosynthetic process (GO:0006506)2.80485573
107ovulation cycle (GO:0042698)2.80028123
108metanephric tubule development (GO:0072170)2.79997603
109metanephric nephron tubule development (GO:0072234)2.79997603
110cAMP biosynthetic process (GO:0006171)2.78766365
111inositol phosphate catabolic process (GO:0071545)2.78331044
112sodium ion export (GO:0071436)2.77638905
113ubiquinone biosynthetic process (GO:0006744)2.76654693
114protein localization to endosome (GO:0036010)2.76174239
115ubiquinone metabolic process (GO:0006743)2.75971737
116negative regulation of astrocyte differentiation (GO:0048712)2.75833590
117regulation of cilium movement (GO:0003352)2.75539121
118mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.74171279
119mitochondrial respiratory chain complex I assembly (GO:0032981)2.74171279
120NADH dehydrogenase complex assembly (GO:0010257)2.74171279
121presynaptic membrane assembly (GO:0097105)2.73328473
122negative regulation of lipase activity (GO:0060192)2.70478252
123signal peptide processing (GO:0006465)2.70398877
124glutathione biosynthetic process (GO:0006750)2.68144872
125response to histamine (GO:0034776)2.68063017
126axoneme assembly (GO:0035082)2.66754996
127anterograde synaptic vesicle transport (GO:0048490)2.66350408
128organic cation transport (GO:0015695)2.65982169
129negative regulation of cytosolic calcium ion concentration (GO:0051481)2.65790623
130endocrine pancreas development (GO:0031018)2.65536225
131transepithelial transport (GO:0070633)2.65103337
132dopamine transport (GO:0015872)2.65002679
133inner ear receptor stereocilium organization (GO:0060122)2.64965040
134regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.64455772
135rhodopsin mediated signaling pathway (GO:0016056)2.63883173
136omega-hydroxylase P450 pathway (GO:0097267)2.63512199
137nephron tubule morphogenesis (GO:0072078)2.63248553
138nephron epithelium morphogenesis (GO:0072088)2.63248553
139aromatic amino acid family catabolic process (GO:0009074)2.59150043
140fucose catabolic process (GO:0019317)2.58750949
141L-fucose metabolic process (GO:0042354)2.58750949
142L-fucose catabolic process (GO:0042355)2.58750949
143RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.58542603
144toxin metabolic process (GO:0009404)2.58496150
145retinal cone cell development (GO:0046549)2.58030493
146regulation of DNA endoreduplication (GO:0032875)2.57059424
147indole-containing compound metabolic process (GO:0042430)2.56623600
148cellular copper ion homeostasis (GO:0006878)2.55564374
149glycolipid biosynthetic process (GO:0009247)2.55070721
150phosphorylated carbohydrate dephosphorylation (GO:0046838)2.54851955
151inositol phosphate dephosphorylation (GO:0046855)2.54851955
152regulation of heart rate by cardiac conduction (GO:0086091)2.53737169
153positive regulation of steroid biosynthetic process (GO:0010893)2.53689145
154cilium organization (GO:0044782)2.53358781
155protein localization to Golgi apparatus (GO:0034067)2.52270214
156primary alcohol catabolic process (GO:0034310)2.51012512
157benzene-containing compound metabolic process (GO:0042537)2.50435931
158metanephric nephron epithelium development (GO:0072243)2.50172781
159positive regulation of hormone metabolic process (GO:0032352)2.50013914
160S-adenosylmethionine metabolic process (GO:0046500)2.49516601
161membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.48099063
162photoreceptor cell development (GO:0042461)2.48047309
163retrograde transport, vesicle recycling within Golgi (GO:0000301)2.47974930
164hyperosmotic salinity response (GO:0042538)2.47184598
165cAMP catabolic process (GO:0006198)2.46927087
166resolution of meiotic recombination intermediates (GO:0000712)2.46039859
167potassium ion homeostasis (GO:0055075)2.45507396
168urate metabolic process (GO:0046415)2.45374974
169negative regulation of sodium ion transport (GO:0010766)2.45372047
170cilium assembly (GO:0042384)2.44974512
171fatty acid oxidation (GO:0019395)2.44020590
172cochlea development (GO:0090102)2.43318515
173cilium morphogenesis (GO:0060271)2.42083775
174somite rostral/caudal axis specification (GO:0032525)2.41757976
175positive regulation of oligodendrocyte differentiation (GO:0048714)2.41058178
176lipid oxidation (GO:0034440)2.39594522
177aspartate family amino acid catabolic process (GO:0009068)2.38147311
178glycerophospholipid catabolic process (GO:0046475)2.37865094
179aggressive behavior (GO:0002118)2.36468538
180mannosylation (GO:0097502)2.36251186
181cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.36055888
182methionine biosynthetic process (GO:0009086)2.35785565
183sulfation (GO:0051923)2.34734889
184nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.34495865
185phosphate ion transport (GO:0006817)2.32829815
186cell volume homeostasis (GO:0006884)2.32005742
187L-phenylalanine catabolic process (GO:0006559)2.30461895
188erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.30461895
189epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.30169679
190cilium movement (GO:0003341)2.27940087
191forebrain neuron development (GO:0021884)2.27710058
192negative regulation of hormone metabolic process (GO:0032351)2.27695849
193negative regulation of hormone biosynthetic process (GO:0032353)2.27695849
194chemosensory behavior (GO:0007635)12.7431152
195sensory perception of chemical stimulus (GO:0007606)11.8101337

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.80857785
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.73154848
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.40321616
4ZFP57_27257070_Chip-Seq_ESCs_Mouse3.18911734
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.13690619
6ZNF274_21170338_ChIP-Seq_K562_Hela3.03330242
7GBX2_23144817_ChIP-Seq_PC3_Human2.82227774
8IGF1R_20145208_ChIP-Seq_DFB_Human2.77227425
9FUS_26573619_Chip-Seq_HEK293_Human2.58259010
10DROSHA_22980978_ChIP-Seq_HELA_Human2.58178313
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.55402436
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.47458809
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.45493138
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.33800830
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.30661739
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.29606063
17ZNF263_19887448_ChIP-Seq_K562_Human2.28927492
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.26062987
19LXR_22158963_ChIP-Seq_LIVER_Mouse2.25584768
20P300_19829295_ChIP-Seq_ESCs_Human2.10234031
21EWS_26573619_Chip-Seq_HEK293_Human2.09099345
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.05878477
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04203890
24ERG_21242973_ChIP-ChIP_JURKAT_Human2.01890795
25CLOCK_20551151_ChIP-Seq_293T_Human1.94939783
26LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94778936
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.90927730
28BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.86956551
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.85718351
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.81096909
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.79464015
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78959623
33ER_23166858_ChIP-Seq_MCF-7_Human1.77740514
34SMAD4_21799915_ChIP-Seq_A2780_Human1.77625871
35ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.71317510
36RNF2_27304074_Chip-Seq_NSC_Mouse1.70764976
37PPARA_22158963_ChIP-Seq_LIVER_Mouse1.67916541
38SOX2_27498859_Chip-Seq_STOMACH_Mouse1.64170988
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57348262
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.55439251
41AR_25329375_ChIP-Seq_VCAP_Human1.55300418
42NR3C1_21868756_ChIP-Seq_MCF10A_Human1.54265746
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52952447
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.51692534
45BCAT_22108803_ChIP-Seq_LS180_Human1.51387589
46STAT3_23295773_ChIP-Seq_U87_Human1.50870792
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49763133
48CBP_20019798_ChIP-Seq_JUKART_Human1.49763133
49EZH2_18974828_ChIP-Seq_MESCs_Mouse1.49721386
50RNF2_18974828_ChIP-Seq_MESCs_Mouse1.49721386
51* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49011099
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46948973
53ERG_20517297_ChIP-Seq_VCAP_Human1.46662168
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46244518
55EZH2_22144423_ChIP-Seq_EOC_Human1.45665215
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45342241
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.45189463
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43857461
59* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43411449
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42009598
61KDM2B_26808549_Chip-Seq_K562_Human1.41686632
62* NANOG_19829295_ChIP-Seq_ESCs_Human1.39588415
63* SOX2_19829295_ChIP-Seq_ESCs_Human1.39588415
64FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.39550359
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.38743973
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38537894
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38303647
68TCF4_23295773_ChIP-Seq_U87_Human1.37183790
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36410540
70EP300_21415370_ChIP-Seq_HL-1_Mouse1.35560834
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35431575
72EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34890021
73RUNX1_27514584_Chip-Seq_MCF-7_Human1.32031246
74AHR_22903824_ChIP-Seq_MCF-7_Human1.31886477
75TCF4_22108803_ChIP-Seq_LS180_Human1.31493084
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.30797402
77* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.30699547
78ETV2_25802403_ChIP-Seq_MESCs_Mouse1.30010853
79TP53_22573176_ChIP-Seq_HFKS_Human1.28559179
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.28446877
81FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27360747
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.26638051
83ESR1_21235772_ChIP-Seq_MCF-7_Human1.26451877
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25042799
85REST_21632747_ChIP-Seq_MESCs_Mouse1.24941061
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24905466
87IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23930138
88RUNX2_22187159_ChIP-Seq_PCA_Human1.23620022
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23582028
90EED_16625203_ChIP-ChIP_MESCs_Mouse1.23482543
91SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.23306579
92AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.22837416
93TAL1_26923725_Chip-Seq_HPCs_Mouse1.22222674
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20667869
95ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20460080
96TAF15_26573619_Chip-Seq_HEK293_Human1.20393555
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19613199
98SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19259908
99CDX2_22108803_ChIP-Seq_LS180_Human1.19076351
100GATA3_24758297_ChIP-Seq_MCF-7_Human1.18863712
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18713458
102EST1_17652178_ChIP-ChIP_JURKAT_Human1.18684932
103SMAD_19615063_ChIP-ChIP_OVARY_Human1.18318049
104MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17633193
105IRF1_19129219_ChIP-ChIP_H3396_Human1.16348513
106SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.15455160
107TP53_18474530_ChIP-ChIP_U2OS_Human1.15051775
108CRX_20693478_ChIP-Seq_RETINA_Mouse1.14918993
109KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14403339
110PRDM14_20953172_ChIP-Seq_ESCs_Human1.14361019
111SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13718334
112P53_22387025_ChIP-Seq_ESCs_Mouse1.13667672
113FLI1_21867929_ChIP-Seq_TH2_Mouse1.13533964
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13419249
115FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13327738
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12971644
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12763776
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12763776
119BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11157808
120* FOXA1_25329375_ChIP-Seq_VCAP_Human1.11038523
121* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11038523
122NCOR_22424771_ChIP-Seq_293T_Human1.10781947
123AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10095045
124E2F1_18555785_Chip-Seq_ESCs_Mouse1.09798025
125RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09513588
126ELK4_26923725_Chip-Seq_MESODERM_Mouse1.09419410
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09387308
128TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09334750
129ARNT_22903824_ChIP-Seq_MCF-7_Human1.08851543
130AR_20517297_ChIP-Seq_VCAP_Human1.08607057
131FOXA2_19822575_ChIP-Seq_HepG2_Human1.08519329
132ELK1_19687146_ChIP-ChIP_HELA_Human1.08367595
133NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07853581
134WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06861345
135ISL1_27105846_Chip-Seq_CPCs_Mouse1.06584054
136SMAD4_21741376_ChIP-Seq_HESCs_Human1.06074720
137OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05381150
138GATA1_19941827_ChIP-Seq_MEL86_Mouse1.04726647
139MYC_19915707_ChIP-ChIP_AK7_Human1.04698995
140NOTCH1_21737748_ChIP-Seq_TLL_Human1.04592302
141GATA3_27048872_Chip-Seq_THYMUS_Human1.04485868
142SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04424130
143P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04079950
144JARID2_20064375_ChIP-Seq_MESCs_Mouse1.03932354
145PIAS1_25552417_ChIP-Seq_VCAP_Human1.03440571
146NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03196736
147SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02959938
148TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01749157
149HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01665121
150HTT_18923047_ChIP-ChIP_STHdh_Human1.00410299
151CMYC_18555785_Chip-Seq_ESCs_Mouse1.00194344
152ATF3_27146783_Chip-Seq_COLON_Human1.00156725
153WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98245672
154FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98064971
155STAT3_18555785_Chip-Seq_ESCs_Mouse0.97476053
156SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97420353
157PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.97390048
158SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97388458
159RACK7_27058665_Chip-Seq_MCF-7_Human0.96915878
160* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95795475
161SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94494631
162GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93273073
163RING1B_27294783_Chip-Seq_ESCs_Mouse0.92500292
164SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92312835
165TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92207235
166CTCF_27219007_Chip-Seq_Bcells_Human0.91974821
167ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91731229
168TBX20_22328084_ChIP-Seq_HEART_Mouse0.91621597
169TBX20_22080862_ChIP-Seq_HEART_Mouse0.91621597
170SMAD3_21741376_ChIP-Seq_HESCs_Human0.91471954
171GF1_26923725_Chip-Seq_HPCs_Mouse0.90654991
172LXR_22292898_ChIP-Seq_THP-1_Human0.90420792
173RARB_27405468_Chip-Seq_BRAIN_Mouse0.90335695
174CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90093410
175ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89007049
176GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.88678283
177DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88144842
178RAD21_21589869_ChIP-Seq_MESCs_Mouse0.86827628
179SMC4_20622854_ChIP-Seq_HELA_Human0.86809601
180SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.86736857
181KLF5_25053715_ChIP-Seq_YYC3_Human0.86702984
182NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.85960613
183AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85951090
184SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85538773
185TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83516092
186SMAD4_21741376_ChIP-Seq_EPCs_Human0.82766538
187EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.82727577
188TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.82717995
189SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80346541
190DPY_21335234_ChIP-Seq_ESCs_Mouse0.79965628

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok6.05977861
2MP0005394_taste/olfaction_phenotype5.95201194
3MP0005499_abnormal_olfactory_system5.95201194
4MP0008789_abnormal_olfactory_epithelium4.46887172
5MP0006072_abnormal_retinal_apoptosis3.13743885
6MP0002876_abnormal_thyroid_physiology2.88855307
7MP0004043_abnormal_pH_regulation2.83151986
8MP0005084_abnormal_gallbladder_morpholo2.81646942
9MP0005253_abnormal_eye_physiology2.68509473
10MP0002638_abnormal_pupillary_reflex2.48505927
11MP0002139_abnormal_hepatobiliary_system2.48073738
12MP0003806_abnormal_nucleotide_metabolis2.47702833
13MP0005551_abnormal_eye_electrophysiolog2.44632904
14MP0003136_yellow_coat_color2.44397281
15MP0003011_delayed_dark_adaptation2.44260932
16MP0010386_abnormal_urinary_bladder2.30933618
17MP0000372_irregular_coat_pigmentation2.25190260
18MP0002837_dystrophic_cardiac_calcinosis2.24503201
19MP0010234_abnormal_vibrissa_follicle2.17875823
20MP0005360_urolithiasis2.14970350
21MP0002102_abnormal_ear_morphology2.04342108
22MP0005365_abnormal_bile_salt2.02694070
23MP0001984_abnormal_olfaction12.4992759
24MP0000427_abnormal_hair_cycle1.99329904
25MP0008872_abnormal_physiological_respon1.97229942
26MP0001529_abnormal_vocalization1.96083485
27MP0003195_calcinosis1.91523763
28MP0002132_abnormal_respiratory_system1.85428814
29MP0000569_abnormal_digit_pigmentation1.82218126
30MP0005646_abnormal_pituitary_gland1.78807001
31MP0002095_abnormal_skin_pigmentation1.71317315
32MP0005645_abnormal_hypothalamus_physiol1.68751571
33MP0003880_abnormal_central_pattern1.68133836
34MP0005083_abnormal_biliary_tract1.66518893
35MP0002736_abnormal_nociception_after1.64924237
36MP0000383_abnormal_hair_follicle1.63121346
37MP0005379_endocrine/exocrine_gland_phen1.58867076
38MP0001968_abnormal_touch/_nociception1.58602191
39MP0003122_maternal_imprinting1.58153433
40MP0010030_abnormal_orbit_morphology1.55303754
41MP0001986_abnormal_taste_sensitivity1.54591102
42MP0009780_abnormal_chondrocyte_physiolo1.53830451
43MP0002938_white_spotting1.53418900
44MP0009745_abnormal_behavioral_response1.52356944
45MP0001486_abnormal_startle_reflex1.47676670
46MP0006276_abnormal_autonomic_nervous1.47604528
47MP0002653_abnormal_ependyma_morphology1.47267954
48MP0008877_abnormal_DNA_methylation1.46754386
49MP0001905_abnormal_dopamine_level1.46748633
50MP0009046_muscle_twitch1.45500420
51MP0002272_abnormal_nervous_system1.44033458
52MP0001756_abnormal_urination1.42597837
53MP0009643_abnormal_urine_homeostasis1.42132678
54MP0002233_abnormal_nose_morphology1.41132747
55MP0000534_abnormal_ureter_morphology1.37411737
56MP0003787_abnormal_imprinting1.33755209
57MP0004147_increased_porphyrin_level1.32188039
58MP0001501_abnormal_sleep_pattern1.29416129
59MP0004019_abnormal_vitamin_homeostasis1.28412354
60MP0004142_abnormal_muscle_tone1.27124203
61MP0001485_abnormal_pinna_reflex1.26686784
62MP0001346_abnormal_lacrimal_gland1.23949552
63MP0004133_heterotaxia1.23615931
64MP0002163_abnormal_gland_morphology1.20377307
65MP0002572_abnormal_emotion/affect_behav1.20019451
66MP0005410_abnormal_fertilization1.17991424
67MP0008058_abnormal_DNA_repair1.14006798
68MP0003329_amyloid_beta_deposits1.13368540
69MP0005391_vision/eye_phenotype1.10604208
70MP0002557_abnormal_social/conspecific_i1.08823982
71MP0000631_abnormal_neuroendocrine_gland1.07140575
72MP0001944_abnormal_pancreas_morphology1.07012007
73MP0005332_abnormal_amino_acid1.06509901
74MP0005195_abnormal_posterior_eye1.05176099
75MP0001970_abnormal_pain_threshold1.04679034
76MP0001765_abnormal_ion_homeostasis1.04522111
77MP0003943_abnormal_hepatobiliary_system1.02342264
78MP0001440_abnormal_grooming_behavior1.02000491
79MP0005171_absent_coat_pigmentation1.01989254
80MP0002734_abnormal_mechanical_nocicepti1.00823842
81MP0003942_abnormal_urinary_system1.00465631
82MP0005584_abnormal_enzyme/coenzyme_acti0.99867663
83MP0010329_abnormal_lipoprotein_level0.97693472
84MP0003252_abnormal_bile_duct0.97361671
85MP0010678_abnormal_skin_adnexa0.96909604
86MP0003075_altered_response_to0.96740356
87MP0006292_abnormal_olfactory_placode0.95443241
88MP0002909_abnormal_adrenal_gland0.95277658
89MP0010094_abnormal_chromosome_stability0.94911903
90MP0002166_altered_tumor_susceptibility0.94740087
91MP0008995_early_reproductive_senescence0.93969314
92MP0005058_abnormal_lysosome_morphology0.92242243
93MP0002064_seizures0.91625211
94MP0000026_abnormal_inner_ear0.91103195
95MP0005623_abnormal_meninges_morphology0.89886052
96MP0004885_abnormal_endolymph0.89189080
97MP0000647_abnormal_sebaceous_gland0.89176685
98MP0002822_catalepsy0.87856453
99MP0002090_abnormal_vision0.86325561
100MP0008961_abnormal_basal_metabolism0.86002684
101MP0005085_abnormal_gallbladder_physiolo0.85272301
102MP0002136_abnormal_kidney_physiology0.84059689
103MP0000604_amyloidosis0.83492109
104MP0002067_abnormal_sensory_capabilities0.82322079
105MP0002896_abnormal_bone_mineralization0.81545394
106MP0002693_abnormal_pancreas_physiology0.80503575
107MP0005174_abnormal_tail_pigmentation0.80379174
108MP0004215_abnormal_myocardial_fiber0.79686713
109MP0005386_behavior/neurological_phenoty0.78761598
110MP0004924_abnormal_behavior0.78761598
111MP0002735_abnormal_chemical_nociception0.77763162
112MP0005075_abnormal_melanosome_morpholog0.77211517
113MP0003878_abnormal_ear_physiology0.76960856
114MP0005377_hearing/vestibular/ear_phenot0.76960856
115MP0002733_abnormal_thermal_nociception0.76749363
116MP0001764_abnormal_homeostasis0.76695249
117MP0003566_abnormal_cell_adhesion0.76413672
118MP0002006_tumorigenesis0.75607292
119MP0003186_abnormal_redox_activity0.75489684
120MP0002160_abnormal_reproductive_system0.75432867
121MP0000639_abnormal_adrenal_gland0.74978625
122MP0003950_abnormal_plasma_membrane0.74083730
123MP0005636_abnormal_mineral_homeostasis0.73150654
124MP0000613_abnormal_salivary_gland0.70546324
125MP0001849_ear_inflammation0.70236816
126MP0004858_abnormal_nervous_system0.69581637
127MP0002184_abnormal_innervation0.66754742
128MP0002138_abnormal_hepatobiliary_system0.59947340
129MP0005310_abnormal_salivary_gland0.57184035
130MP0005319_abnormal_enzyme/_coenzyme0.55084415
131MP0005266_abnormal_metabolism0.54474317
132MP0002752_abnormal_somatic_nervous0.53859023
133MP0002928_abnormal_bile_duct0.53586383
134MP0003300_gastrointestinal_ulcer0.53298507
135MP0002168_other_aberrant_phenotype0.52233985
136MP0002282_abnormal_trachea_morphology0.52184853
137MP0000609_abnormal_liver_physiology0.52100966
138MP0005187_abnormal_penis_morphology0.51818675
139MP0002249_abnormal_larynx_morphology0.51713068
140MP0005451_abnormal_body_composition0.51629986
141MP0005395_other_phenotype0.50495837
142MP0002877_abnormal_melanocyte_morpholog0.50393894
143MP0002295_abnormal_pulmonary_circulatio0.50176803
144MP0005408_hypopigmentation0.49234897
145MP0002118_abnormal_lipid_homeostasis0.48882251
146MP0004859_abnormal_synaptic_plasticity0.48340390
147MP0003705_abnormal_hypodermis_morpholog0.47887694
148MP0001915_intracranial_hemorrhage0.46696037
149MP0005367_renal/urinary_system_phenotyp0.46658320
150MP0000516_abnormal_urinary_system0.46658320
151MP0003633_abnormal_nervous_system0.44115992
152MP0005167_abnormal_blood-brain_barrier0.43925134
153MP0001299_abnormal_eye_distance/0.43913599
154MP0002063_abnormal_learning/memory/cond0.43444110
155MP0000465_gastrointestinal_hemorrhage0.42614284
156MP0003718_maternal_effect0.42330534
157MP0008874_decreased_physiological_sensi0.42266502
158MP0002135_abnormal_kidney_morphology0.41419409
159MP0000538_abnormal_urinary_bladder0.41016471
160MP0003283_abnormal_digestive_organ0.39782507
161MP0002882_abnormal_neuron_morphology0.38989739
162MP0009384_cardiac_valve_regurgitation0.37826859
163MP0003937_abnormal_limbs/digits/tail_de0.37671145
164MP0002234_abnormal_pharynx_morphology0.37086553
165MP0003690_abnormal_glial_cell0.36632092
166MP0006054_spinal_hemorrhage0.36405249
167MP0009764_decreased_sensitivity_to0.36386276
168MP0005508_abnormal_skeleton_morphology0.35898518
169MP0003635_abnormal_synaptic_transmissio0.35494387
170MP0009250_abnormal_appendicular_skeleto0.35022156
171MP0004264_abnormal_extraembryonic_tissu0.34607529
172MP0001270_distended_abdomen0.33589243
173MP0003938_abnormal_ear_development0.33503117
174MP0005248_abnormal_Harderian_gland0.32672747
175MP0003935_abnormal_craniofacial_develop0.31608041
176MP0004270_analgesia0.31303552
177MP0002115_abnormal_skeleton_extremities0.30965730
178MP0002092_abnormal_eye_morphology0.30891728

Predicted human phenotypes

RankGene SetZ-score
1Metabolic alkalosis (HP:0200114)6.04018145
2B lymphocytopenia (HP:0010976)5.85690544
3Hyperaldosteronism (HP:0000859)5.83329826
4Polyuria (HP:0000103)5.59779584
5Thyroiditis (HP:0100646)5.54242388
6Hypokalemic alkalosis (HP:0001949)5.52213004
7Abnormal drinking behavior (HP:0030082)5.50045524
8Polydipsia (HP:0001959)5.50045524
9Abnormality of B cell number (HP:0010975)5.32462898
10Abnormal urine output (HP:0012590)5.27591098
11Hyperactive renin-angiotensin system (HP:0000841)5.14537313
12Severe combined immunodeficiency (HP:0004430)5.12303074
13Decreased circulating renin level (HP:0003351)5.07866955
14Abnormality of renin-angiotensin system (HP:0000847)5.03406471
15Hypoproteinemia (HP:0003075)4.92907416
16Abnormality of chloride homeostasis (HP:0011422)4.91783845
17Abnormality of renal excretion (HP:0011036)4.80276047
18Increased circulating renin level (HP:0000848)4.73297023
19Hypoplasia of the thymus (HP:0000778)4.52170553
20Ulnar bowing (HP:0003031)4.31353842
21Abnormality of sodium homeostasis (HP:0010931)4.31029280
22Renal salt wasting (HP:0000127)4.10506483
23Panhypogammaglobulinemia (HP:0003139)4.06993115
24Hypokalemia (HP:0002900)4.00420286
25Combined immunodeficiency (HP:0005387)3.86506661
26Hypomagnesemia (HP:0002917)3.74969277
27True hermaphroditism (HP:0010459)3.72785569
28Gout (HP:0001997)3.70210080
29Abnormality of dentin (HP:0010299)3.58039856
30Bilateral sensorineural hearing impairment (HP:0008619)3.57994222
31Decreased central vision (HP:0007663)3.55126138
32Pancreatic cysts (HP:0001737)3.43907722
33Abolished electroretinogram (ERG) (HP:0000550)3.43265466
34Atrioventricular block (HP:0001678)3.38391633
35Alkalosis (HP:0001948)3.34944147
36Bifid scrotum (HP:0000048)3.34771109
37Pancreatic fibrosis (HP:0100732)3.34739365
38Hypercalciuria (HP:0002150)3.33409763
39Synostosis involving the elbow (HP:0003938)3.30055104
40Humeroradial synostosis (HP:0003041)3.30055104
41Abnormality of potassium homeostasis (HP:0011042)3.29005504
42Attenuation of retinal blood vessels (HP:0007843)3.26933754
43Aplasia/Hypoplasia of the tibia (HP:0005772)3.12307828
44Large for gestational age (HP:0001520)3.10788944
45Type II lissencephaly (HP:0007260)3.09372762
46Palpitations (HP:0001962)3.03879921
47Tetany (HP:0001281)2.98400986
48Adrenal overactivity (HP:0002717)2.98091766
49Erythroderma (HP:0001019)2.97023612
50Methylmalonic acidemia (HP:0002912)2.96999383
51Ketoacidosis (HP:0001993)2.94973698
52Bronchomalacia (HP:0002780)2.94895603
53Renal tubular acidosis (HP:0001947)2.93502210
54Congenital stationary night blindness (HP:0007642)2.92152222
55Abnormality of magnesium homeostasis (HP:0004921)2.92081567
56Short tibia (HP:0005736)2.91338394
57Hyperglycinuria (HP:0003108)2.88694042
58Febrile seizures (HP:0002373)2.88519397
59Type 2 muscle fiber atrophy (HP:0003554)2.85789863
60Bony spicule pigmentary retinopathy (HP:0007737)2.78211128
61Decreased electroretinogram (ERG) amplitude (HP:0000654)2.76641141
62Increased purine levels (HP:0004368)2.73387254
63Hyperuricemia (HP:0002149)2.73387254
64Syncope (HP:0001279)2.73019364
65Molar tooth sign on MRI (HP:0002419)2.71259397
66Abnormality of midbrain morphology (HP:0002418)2.71259397
67Limb dystonia (HP:0002451)2.67970580
68Abnormality of the renal cortex (HP:0011035)2.66990838
69Chronic bronchitis (HP:0004469)2.63393055
70Prolonged QT interval (HP:0001657)2.63384217
71Arterial tortuosity (HP:0005116)2.62090705
72Renal cortical cysts (HP:0000803)2.61796780
73Volvulus (HP:0002580)2.61315509
74Choanal stenosis (HP:0000452)2.60838690
75Congenital sensorineural hearing impairment (HP:0008527)2.56680877
76Abnormality of serine family amino acid metabolism (HP:0010894)2.51994835
77Abnormality of glycine metabolism (HP:0010895)2.51994835
78Vaginal fistula (HP:0004320)2.47144310
79Medial flaring of the eyebrow (HP:0010747)2.46641171
80Chronic sinusitis (HP:0011109)2.45377988
81Ketosis (HP:0001946)2.43100286
82Abnormal rod and cone electroretinograms (HP:0008323)2.41856909
83Torticollis (HP:0000473)2.41303009
84Bowed forearm bones (HP:0003956)2.37528346
85Bowing of the arm (HP:0006488)2.37528346
86Abnormal respiratory motile cilium physiology (HP:0012261)2.37524882
87Tubulointerstitial fibrosis (HP:0005576)2.36863534
88Colon cancer (HP:0003003)2.35703990
89Abnormality of macular pigmentation (HP:0008002)2.35382520
90Vascular tortuosity (HP:0004948)2.35147303
91Intestinal atresia (HP:0011100)2.34953477
92Nephronophthisis (HP:0000090)2.33225336
93Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.30731519
94Chronic hepatic failure (HP:0100626)2.30237585
95Lip pit (HP:0100267)2.29463350
96Hepatic necrosis (HP:0002605)2.26110436
97Femoral bowing (HP:0002980)2.24459371
98Hemiparesis (HP:0001269)2.23963220
99Heart block (HP:0012722)2.23471355
100Abnormality of purine metabolism (HP:0004352)2.22385083
101Male infertility (HP:0003251)2.19672622
102Abnormality of glutamine family amino acid metabolism (HP:0010902)2.18409086
103IgG deficiency (HP:0004315)2.17378572
104Craniofacial dystonia (HP:0012179)2.17260790
105Hyperglycinemia (HP:0002154)2.16012929
106Hyperlipoproteinemia (HP:0010980)2.14746012
107Abnormality of vitamin B metabolism (HP:0004340)2.13067263
108Gastrointestinal atresia (HP:0002589)2.08319542
109Absent rod-and cone-mediated responses on ERG (HP:0007688)2.08130461
110Disproportionate short-trunk short stature (HP:0003521)2.07673746
111T lymphocytopenia (HP:0005403)2.07642721
112Focal motor seizures (HP:0011153)2.07492784
113Delayed CNS myelination (HP:0002188)2.07363605
114Hypoglycemic coma (HP:0001325)2.07241954
115Eosinophilia (HP:0001880)2.06167376
116Chondrocalcinosis (HP:0000934)2.05895753
117Abnormal atrioventricular conduction (HP:0005150)2.05570591
118Deep venous thrombosis (HP:0002625)2.05301502
119Abnormality of eosinophils (HP:0001879)2.04713735
120Methylmalonic aciduria (HP:0012120)2.04308936
121Aplasia/Hypoplasia of the tongue (HP:0010295)2.03326647
122Genital tract atresia (HP:0001827)2.01976872
123Muscle fiber atrophy (HP:0100295)2.01146759
124Dysphonia (HP:0001618)2.00975587
125Abnormality of the renal medulla (HP:0100957)1.99772630
126Abnormal respiratory epithelium morphology (HP:0012253)1.99474932
127Abnormal respiratory motile cilium morphology (HP:0005938)1.99474932
128Anencephaly (HP:0002323)1.98051702
129Focal dystonia (HP:0004373)1.96916620
130Abnormality of Sharpey fibers (HP:0100685)1.96312560
131Pendular nystagmus (HP:0012043)1.96258917
132Abnormal protein glycosylation (HP:0012346)1.95517882
133Abnormal glycosylation (HP:0012345)1.95517882
134Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95517882
135Abnormal protein N-linked glycosylation (HP:0012347)1.95517882
136Congenital primary aphakia (HP:0007707)1.95326096
137Severe muscular hypotonia (HP:0006829)1.95208651
138Gait imbalance (HP:0002141)1.94543880
139Neonatal onset (HP:0003623)1.93892482
140Constricted visual fields (HP:0001133)1.92589673
141Generalized aminoaciduria (HP:0002909)1.90155894
142Poikilocytosis (HP:0004447)1.89906287
143Abnormal ciliary motility (HP:0012262)1.89246555
144Tubulointerstitial abnormality (HP:0001969)1.89082222
145Macular degeneration (HP:0000608)1.88381559
146Increased CSF lactate (HP:0002490)1.88034271
147Proximal tubulopathy (HP:0000114)1.87741375
148Hepatocellular necrosis (HP:0001404)1.86774939
149Nephrogenic diabetes insipidus (HP:0009806)1.86702618
150Protrusio acetabuli (HP:0003179)1.86545111
151Labial hypoplasia (HP:0000066)1.85266806
152Anosmia (HP:0000458)1.85111744
153Hypothermia (HP:0002045)1.84993875
154Abnormality of aromatic amino acid family metabolism (HP:0004338)1.84774982
155Furrowed tongue (HP:0000221)1.84589986
156Cystic liver disease (HP:0006706)1.84000008
157Mitochondrial inheritance (HP:0001427)1.83443845
158Acute necrotizing encephalopathy (HP:0006965)1.83205091
159Progressive macrocephaly (HP:0004481)1.81772895
160Hypoplasia of the pons (HP:0012110)1.81609888
161Retinitis pigmentosa (HP:0000510)1.81462809
162Abnormality of the pons (HP:0007361)1.81337084
163Retinal dysplasia (HP:0007973)1.79812004
164Xanthomatosis (HP:0000991)1.79650137
165Turricephaly (HP:0000262)1.79102034
166Abnormality of vitamin metabolism (HP:0100508)1.78819154
167Type I transferrin isoform profile (HP:0003642)1.78339653
168Facial shape deformation (HP:0011334)1.78316035
169Potter facies (HP:0002009)1.78316035
170Nephrocalcinosis (HP:0000121)1.76886138
171Polycythemia (HP:0001901)1.76414662
172Choroideremia (HP:0001139)1.75987601
173Nonprogressive disorder (HP:0003680)1.75937935
174Vaginal atresia (HP:0000148)1.75351784
175Atonic seizures (HP:0010819)1.75304465
176Abnormality of T cell number (HP:0011839)1.75228481
177Amelogenesis imperfecta (HP:0000705)1.75193167
178Glycosuria (HP:0003076)1.75164983
179Abnormality of urine glucose concentration (HP:0011016)1.75164983
180Complement deficiency (HP:0004431)1.74913543
181Dialeptic seizures (HP:0011146)1.74909437
182Vacuolated lymphocytes (HP:0001922)1.74906930
183Malnutrition (HP:0004395)1.74585004
184Hypoalbuminemia (HP:0003073)1.74552061
185Abnormal albumin level (HP:0012116)1.74552061
186Abnormality of the vitamin B12 metabolism (HP:0004341)1.74241594
187Abnormal EKG (HP:0003115)1.73938596
188Dehydration (HP:0001944)1.71152516
189Abnormality of fatty-acid metabolism (HP:0004359)1.68771806
190Primary atrial arrhythmia (HP:0001692)1.67215716
191Rickets (HP:0002748)1.64979858
192Hypoplastic female external genitalia (HP:0012815)1.62674936
193Hyponatremia (HP:0002902)1.62577624
194Nephrolithiasis (HP:0000787)1.62498937
195Rhinitis (HP:0012384)1.62352597

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK64.19658560
2OXSR14.08155476
3WNK43.95374122
4WNK33.92300634
5LATS13.41593160
6STK393.33949669
7STK163.06860592
8MAPK152.82119054
9TYRO32.77972651
10BMPR1B2.36749986
11PAK32.26837106
12RIPK12.16309360
13INSRR2.00492651
14MAPK131.93878424
15MAPKAPK31.91373818
16PDK41.90910895
17PDK31.90910895
18CASK1.89306074
19TRIB31.87372063
20EEF2K1.87274276
21NEK11.85238599
22TAOK31.83636265
23ADRBK21.82608114
24MAP3K121.81819844
25EIF2AK31.73105680
26NME11.70768826
27PRKD31.68982846
28SIK11.65725771
29ZAK1.56665591
30CAMK2D1.56399950
31TTK1.54369455
32GRK11.53459319
33CAMK2B1.51096515
34STK38L1.45691731
35KSR21.43861447
36MAP2K71.41839985
37TGFBR21.41746158
38TESK11.39503456
39LMTK21.38450387
40HIPK21.34349685
41MKNK21.32245825
42PIK3CG1.29510042
43PRKCE1.28760092
44SIK21.27505662
45PKN21.25047108
46DAPK21.24154500
47ERBB31.21078896
48CSNK1A1L1.20587162
49FRK1.16016818
50CAMK2G1.15705231
51PAK61.14581228
52PDK21.14502457
53EPHA41.10467102
54CAMKK21.09637862
55MAP3K21.09347409
56WNK11.07897281
57MAP4K21.05958820
58ERBB41.05743848
59NTRK11.03786152
60PNCK1.02894870
61BCKDK1.02064850
62CDK31.01407840
63SGK4941.00010732
64SGK2231.00010732
65MST1R0.99992770
66FER0.99952367
67PLK20.99660548
68ERN10.98433210
69TRIM280.97994304
70CSNK1G10.96400652
71STK30.96085168
72MUSK0.94076645
73MAP3K70.93256903
74GRK60.92394036
75DDR20.90272014
76MAP3K60.89510451
77CSNK1G20.89353484
78MAP2K40.88859469
79MAPKAPK50.88849939
80EPHB10.87183267
81TIE10.86723165
82VRK10.86278671
83MYLK0.86069354
84PKN10.85463818
85MAP3K40.84385153
86CSNK1G30.82226953
87STK380.77902909
88LRRK20.76837731
89SGK30.74216134
90MAP3K90.72066319
91PHKG20.70966328
92PHKG10.70966328
93ILK0.70671472
94SIK30.70488828
95MAP2K10.69916003
96LATS20.69589405
97TAOK10.69182108
98PLK40.68920249
99TGFBR10.68526298
100SCYL20.67242535
101PDPK10.66188398
102NEK60.62543665
103LIMK10.61938379
104ICK0.61731945
105PINK10.60708406
106ALK0.57994367
107CDK60.57797375
108PRKCG0.57008094
109PRKD10.56414213
110DYRK1B0.55839652
111WEE10.55571988
112NTRK20.54892792
113PRKG10.54057406
114NTRK30.53869749
115SGK20.53855014
116PTK60.53203980
117STK240.52070118
118ABL10.50993404
119PRKACA0.50655794
120PRKG20.50598384
121DYRK20.50552781
122BRD40.50114545
123ROCK10.48138017
124PDGFRA0.47948392
125PRKCH0.47934303
126BRSK20.46864762
127PRKD20.46677963
128MARK10.46114189
129PAK40.46086460
130RET0.45368321
131CAMK2A0.44560208
132AKT30.44440943
133FGFR20.44371502
134PRKAA10.44253314
135CDK80.44215664
136PASK0.44084072
137ADRBK10.43137714
138OBSCN0.42941629
139MINK10.42756919
140TLK10.42499348
141MKNK10.41631395
142PRKCQ0.41300184
143PTK20.41067434
144STK110.40336244
145ROCK20.38281144
146PLK30.38114168
147PTK2B0.38041088
148NLK0.37525695
149MOS0.37302217
150PRKCA0.37255916
151STK100.36672034
152BMX0.35766161
153MAP2K60.35103835
154TXK0.34927945
155ERBB20.34465102
156NUAK10.32314378
157MST40.32081319
158BMPR20.31512930
159CDK50.31440552
160TRPM70.30957624
161CAMKK10.30070516
162CSK0.28943797
163MET0.27357728
164NEK90.27117058
165DAPK10.26780889

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.44516771
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.70324506
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.44680227
4Pentose and glucuronate interconversions_Homo sapiens_hsa000403.26130838
5Butanoate metabolism_Homo sapiens_hsa006503.17435101
6Non-homologous end-joining_Homo sapiens_hsa034503.10512632
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.96926857
8Caffeine metabolism_Homo sapiens_hsa002322.79574696
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.62136587
10Phototransduction_Homo sapiens_hsa047442.58705193
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.56546787
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.41486840
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.34494795
14Nicotine addiction_Homo sapiens_hsa050332.31704840
15One carbon pool by folate_Homo sapiens_hsa006702.12277633
16Bile secretion_Homo sapiens_hsa049762.08209645
17Sulfur metabolism_Homo sapiens_hsa009201.99740485
18Asthma_Homo sapiens_hsa053101.99618357
19beta-Alanine metabolism_Homo sapiens_hsa004101.91495267
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.87402247
21Propanoate metabolism_Homo sapiens_hsa006401.80138923
22Oxidative phosphorylation_Homo sapiens_hsa001901.75328783
23Histidine metabolism_Homo sapiens_hsa003401.73569841
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.70709325
25Type I diabetes mellitus_Homo sapiens_hsa049401.68027096
26Protein export_Homo sapiens_hsa030601.66280654
27Pyruvate metabolism_Homo sapiens_hsa006201.63153891
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.58208211
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57985673
30Collecting duct acid secretion_Homo sapiens_hsa049661.55537143
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.55322930
32Fatty acid degradation_Homo sapiens_hsa000711.51045750
33Tryptophan metabolism_Homo sapiens_hsa003801.48305984
34Homologous recombination_Homo sapiens_hsa034401.46342429
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45424643
36Salivary secretion_Homo sapiens_hsa049701.44265917
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.41907873
38Chemical carcinogenesis_Homo sapiens_hsa052041.41874169
39Vibrio cholerae infection_Homo sapiens_hsa051101.41836966
40Linoleic acid metabolism_Homo sapiens_hsa005911.41562654
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41536348
42Primary immunodeficiency_Homo sapiens_hsa053401.39917028
43Nitrogen metabolism_Homo sapiens_hsa009101.39165760
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.34068772
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33878580
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.31050587
47Gastric acid secretion_Homo sapiens_hsa049711.26941150
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26236838
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.24490474
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21473256
51Parkinsons disease_Homo sapiens_hsa050121.19317100
52Fanconi anemia pathway_Homo sapiens_hsa034601.15637963
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14389935
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09590456
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07825525
56RNA degradation_Homo sapiens_hsa030181.04863266
57Primary bile acid biosynthesis_Homo sapiens_hsa001201.04393845
58Allograft rejection_Homo sapiens_hsa053301.03799525
59Graft-versus-host disease_Homo sapiens_hsa053321.03352893
60Arginine biosynthesis_Homo sapiens_hsa002201.01881029
61Drug metabolism - other enzymes_Homo sapiens_hsa009831.01327984
62Autoimmune thyroid disease_Homo sapiens_hsa053201.00370205
63Starch and sucrose metabolism_Homo sapiens_hsa005000.99972793
64Retinol metabolism_Homo sapiens_hsa008300.99312756
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98970051
66* Thyroid hormone synthesis_Homo sapiens_hsa049180.92065971
67Ovarian steroidogenesis_Homo sapiens_hsa049130.90805407
68Ether lipid metabolism_Homo sapiens_hsa005650.90303141
69Fatty acid elongation_Homo sapiens_hsa000620.90235063
70* Glutathione metabolism_Homo sapiens_hsa004800.89006861
71Antigen processing and presentation_Homo sapiens_hsa046120.88101239
72ABC transporters_Homo sapiens_hsa020100.83595889
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83218321
74Legionellosis_Homo sapiens_hsa051340.82545188
75Rheumatoid arthritis_Homo sapiens_hsa053230.82155217
76Basal transcription factors_Homo sapiens_hsa030220.81986707
77Proteasome_Homo sapiens_hsa030500.81381443
78Insulin secretion_Homo sapiens_hsa049110.79321818
79Arginine and proline metabolism_Homo sapiens_hsa003300.78998299
80PPAR signaling pathway_Homo sapiens_hsa033200.78710298
81Synaptic vesicle cycle_Homo sapiens_hsa047210.78701363
82Morphine addiction_Homo sapiens_hsa050320.75350553
83Fatty acid metabolism_Homo sapiens_hsa012120.75179995
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73711044
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.73261276
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71475997
87Cardiac muscle contraction_Homo sapiens_hsa042600.70007924
88Mineral absorption_Homo sapiens_hsa049780.69729870
89Peroxisome_Homo sapiens_hsa041460.69282117
90Serotonergic synapse_Homo sapiens_hsa047260.68554470
91Selenocompound metabolism_Homo sapiens_hsa004500.68252607
92Regulation of autophagy_Homo sapiens_hsa041400.66908029
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66505001
94Estrogen signaling pathway_Homo sapiens_hsa049150.65675197
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62411223
96Carbon metabolism_Homo sapiens_hsa012000.61586915
97cAMP signaling pathway_Homo sapiens_hsa040240.60439739
98Circadian entrainment_Homo sapiens_hsa047130.60029997
99Dopaminergic synapse_Homo sapiens_hsa047280.59755297
100Sphingolipid metabolism_Homo sapiens_hsa006000.59228068
101Mismatch repair_Homo sapiens_hsa034300.59077400
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58197584
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56884980
104Alzheimers disease_Homo sapiens_hsa050100.56626852
105Phenylalanine metabolism_Homo sapiens_hsa003600.54698668
106GABAergic synapse_Homo sapiens_hsa047270.53996036
107Purine metabolism_Homo sapiens_hsa002300.52415571
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51381708
109Metabolic pathways_Homo sapiens_hsa011000.51359130
110Huntingtons disease_Homo sapiens_hsa050160.49652101
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46605827
112RNA polymerase_Homo sapiens_hsa030200.46503606
113* Arachidonic acid metabolism_Homo sapiens_hsa005900.46164717
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46089021
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45626728
116GnRH signaling pathway_Homo sapiens_hsa049120.45055153
117Biosynthesis of amino acids_Homo sapiens_hsa012300.43804734
118Calcium signaling pathway_Homo sapiens_hsa040200.42009997
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41296534
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40440534
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40369456
122Renin secretion_Homo sapiens_hsa049240.39499288
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38586411
124Fatty acid biosynthesis_Homo sapiens_hsa000610.37548655
125Pancreatic secretion_Homo sapiens_hsa049720.36796988
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36239250
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35841693
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35293950
129Taste transduction_Homo sapiens_hsa047420.34421518
130Cocaine addiction_Homo sapiens_hsa050300.33892521
131Hedgehog signaling pathway_Homo sapiens_hsa043400.33307997
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33254948
133Glutamatergic synapse_Homo sapiens_hsa047240.33208257
134Sulfur relay system_Homo sapiens_hsa041220.32185526
135Lysine degradation_Homo sapiens_hsa003100.31968796
136Complement and coagulation cascades_Homo sapiens_hsa046100.31206011
137TGF-beta signaling pathway_Homo sapiens_hsa043500.30409037
138Glycerolipid metabolism_Homo sapiens_hsa005610.29742298
139Lysosome_Homo sapiens_hsa041420.29693064
140Cholinergic synapse_Homo sapiens_hsa047250.27928004
141Adherens junction_Homo sapiens_hsa045200.26642753
142Dorso-ventral axis formation_Homo sapiens_hsa043200.26391487
143Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25625122
144Melanogenesis_Homo sapiens_hsa049160.25457580
145Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.25341013
146Insulin resistance_Homo sapiens_hsa049310.25321723
147Adipocytokine signaling pathway_Homo sapiens_hsa049200.22721317
148Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22704398
149Gap junction_Homo sapiens_hsa045400.22373192
150Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22072814
151Axon guidance_Homo sapiens_hsa043600.21959654
152Oxytocin signaling pathway_Homo sapiens_hsa049210.21637774
153Dilated cardiomyopathy_Homo sapiens_hsa054140.21410833
154Protein digestion and absorption_Homo sapiens_hsa049740.18664930
155Amphetamine addiction_Homo sapiens_hsa050310.18015499

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