GPT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.35678382
2L-phenylalanine catabolic process (GO:0006559)7.35678382
3L-phenylalanine metabolic process (GO:0006558)7.11517294
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.11517294
5epoxygenase P450 pathway (GO:0019373)7.10345356
6aromatic amino acid family catabolic process (GO:0009074)6.53102763
7exogenous drug catabolic process (GO:0042738)6.45607397
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.27599206
9tryptophan catabolic process (GO:0006569)5.82178793
10indole-containing compound catabolic process (GO:0042436)5.82178793
11indolalkylamine catabolic process (GO:0046218)5.82178793
12kynurenine metabolic process (GO:0070189)5.72617078
13omega-hydroxylase P450 pathway (GO:0097267)5.71672014
14sulfur amino acid catabolic process (GO:0000098)5.64512687
15bile acid biosynthetic process (GO:0006699)5.63702644
16glyoxylate metabolic process (GO:0046487)5.60226786
17urea cycle (GO:0000050)5.57755297
18urea metabolic process (GO:0019627)5.57755297
19alpha-linolenic acid metabolic process (GO:0036109)5.48103677
20tryptophan metabolic process (GO:0006568)5.46712763
21cysteine metabolic process (GO:0006534)5.32673895
22high-density lipoprotein particle remodeling (GO:0034375)5.31718730
23negative regulation of fibrinolysis (GO:0051918)5.15065299
24nitrogen cycle metabolic process (GO:0071941)5.14522317
25ethanol metabolic process (GO:0006067)5.14435037
26complement activation, alternative pathway (GO:0006957)5.10025535
27protein carboxylation (GO:0018214)5.07553542
28peptidyl-glutamic acid carboxylation (GO:0017187)5.07553542
29regulation of plasminogen activation (GO:0010755)5.05764388
30serine family amino acid catabolic process (GO:0009071)5.05562966
31drug metabolic process (GO:0017144)5.02549095
32regulation of protein activation cascade (GO:2000257)4.97504621
33NADH metabolic process (GO:0006734)4.97327421
34bile acid metabolic process (GO:0008206)4.96601102
35regulation of fibrinolysis (GO:0051917)4.94331405
36regulation of triglyceride catabolic process (GO:0010896)4.94282853
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.84643899
38homocysteine metabolic process (GO:0050667)4.75409749
39regulation of cholesterol esterification (GO:0010872)4.75020587
40aromatic amino acid family metabolic process (GO:0009072)4.74785261
41triglyceride homeostasis (GO:0070328)4.73102466
42acylglycerol homeostasis (GO:0055090)4.73102466
43reverse cholesterol transport (GO:0043691)4.66642311
44regulation of complement activation (GO:0030449)4.65728589
45lysine metabolic process (GO:0006553)4.61640169
46lysine catabolic process (GO:0006554)4.61640169
47protein-lipid complex remodeling (GO:0034368)4.61064671
48macromolecular complex remodeling (GO:0034367)4.61064671
49plasma lipoprotein particle remodeling (GO:0034369)4.61064671
50tyrosine metabolic process (GO:0006570)4.60144369
51amino-acid betaine metabolic process (GO:0006577)4.55889711
52* alpha-amino acid catabolic process (GO:1901606)4.51607078
53phospholipid efflux (GO:0033700)4.46918823
54negative regulation of sterol transport (GO:0032372)4.44117175
55negative regulation of cholesterol transport (GO:0032375)4.44117175
56plasma lipoprotein particle clearance (GO:0034381)4.38309867
57cellular ketone body metabolic process (GO:0046950)4.23665707
58glycine metabolic process (GO:0006544)4.23431835
59oxaloacetate metabolic process (GO:0006107)4.23413281
60cholesterol efflux (GO:0033344)4.23235129
61coenzyme catabolic process (GO:0009109)4.21910939
62* cellular amino acid catabolic process (GO:0009063)4.21740590
63bile acid and bile salt transport (GO:0015721)4.21152629
64ethanol oxidation (GO:0006069)4.17310701
65cellular glucuronidation (GO:0052695)4.10794418
66serine family amino acid metabolic process (GO:0009069)4.10356730
67imidazole-containing compound metabolic process (GO:0052803)4.10265253
68glutamate metabolic process (GO:0006536)4.09982949
69indolalkylamine metabolic process (GO:0006586)4.09025248
70plasma lipoprotein particle assembly (GO:0034377)4.07822163
71complement activation, classical pathway (GO:0006958)4.07222098
72very-low-density lipoprotein particle assembly (GO:0034379)4.03921321
73cellular biogenic amine catabolic process (GO:0042402)4.01905683
74amine catabolic process (GO:0009310)4.01905683
75cellular modified amino acid catabolic process (GO:0042219)3.98013023
76complement activation (GO:0006956)3.94325978
77drug catabolic process (GO:0042737)3.92608231
78benzene-containing compound metabolic process (GO:0042537)3.92303967
79acetyl-CoA metabolic process (GO:0006084)3.91351041
80creatine metabolic process (GO:0006600)3.90581319
81serine family amino acid biosynthetic process (GO:0009070)3.89437437
82intestinal cholesterol absorption (GO:0030299)3.88944645
83fructose metabolic process (GO:0006000)3.87371887
84arginine metabolic process (GO:0006525)3.86730007
85protein activation cascade (GO:0072376)3.85944194
86regulation of cholesterol homeostasis (GO:2000188)3.84099379
87cholesterol homeostasis (GO:0042632)3.82139519
88positive regulation of triglyceride lipase activity (GO:0061365)3.81642065
89positive regulation of lipoprotein lipase activity (GO:0051006)3.81642065
90dicarboxylic acid biosynthetic process (GO:0043650)3.80906546
91positive regulation of lipid catabolic process (GO:0050996)3.80609026
92response to mercury ion (GO:0046689)3.80601766
93low-density lipoprotein particle remodeling (GO:0034374)3.80066430
94* organic acid catabolic process (GO:0016054)3.76384253
95* carboxylic acid catabolic process (GO:0046395)3.76384253
96sterol homeostasis (GO:0055092)3.75587140
97regulation of bile acid biosynthetic process (GO:0070857)3.75031837
98short-chain fatty acid metabolic process (GO:0046459)3.71597804
99cytolysis (GO:0019835)3.70511093
100phospholipid homeostasis (GO:0055091)3.68906976
101negative regulation of lipase activity (GO:0060192)3.68513698
102protein-lipid complex assembly (GO:0065005)3.67038997
103fibrinolysis (GO:0042730)3.66260215
104ketone body metabolic process (GO:1902224)3.65863798
105fatty acid beta-oxidation (GO:0006635)3.64142128
106oxidative demethylation (GO:0070989)3.63878113
107aldehyde catabolic process (GO:0046185)3.62862062
108glucuronate metabolic process (GO:0019585)3.61610197
109uronic acid metabolic process (GO:0006063)3.61610197
110plasma lipoprotein particle organization (GO:0071827)3.61331089
111fatty acid oxidation (GO:0019395)3.59930032
112phenylpropanoid metabolic process (GO:0009698)3.59207769
113negative regulation of fatty acid biosynthetic process (GO:0045717)3.58768875
114monocarboxylic acid catabolic process (GO:0072329)3.57576570
115cofactor catabolic process (GO:0051187)3.57541820
116flavonoid metabolic process (GO:0009812)3.56495703
117blood coagulation, intrinsic pathway (GO:0007597)3.52006054
118acute-phase response (GO:0006953)3.51330569
119intestinal absorption (GO:0050892)3.50591391
120positive regulation of fatty acid biosynthetic process (GO:0045723)3.46435405
121regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.46238740
122fat-soluble vitamin biosynthetic process (GO:0042362)3.42420318
123negative regulation of blood coagulation (GO:0030195)3.41886770
124negative regulation of hemostasis (GO:1900047)3.41886770
125alkaloid metabolic process (GO:0009820)3.40139987
126regulation of sequestering of triglyceride (GO:0010889)3.38000944
127hormone catabolic process (GO:0042447)3.36050520
1282-oxoglutarate metabolic process (GO:0006103)3.20438927
129diacylglycerol metabolic process (GO:0046339)3.15255503
130muscle filament sliding (GO:0030049)3.13071357
131actin-myosin filament sliding (GO:0033275)3.13071357
132primary alcohol metabolic process (GO:0034308)3.11614733
133positive regulation of fatty acid metabolic process (GO:0045923)3.10908377
134regulation of humoral immune response (GO:0002920)3.09607326
135positive regulation of triglyceride metabolic process (GO:0090208)3.09295318
136negative regulation of coagulation (GO:0050819)3.08237506
137proline metabolic process (GO:0006560)3.06334352
138fatty acid catabolic process (GO:0009062)3.03867211
139negative regulation of wound healing (GO:0061045)3.00304812
140primary alcohol catabolic process (GO:0034310)2.99799515
141protein-lipid complex subunit organization (GO:0071825)2.99148542
142fatty acid transmembrane transport (GO:1902001)2.99142457
143angiotensin maturation (GO:0002003)2.96196185
144carnitine shuttle (GO:0006853)2.95933732

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.17513555
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.02614558
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.43998244
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.32427396
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.71664679
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.24167113
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.89225328
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.03574928
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.83812873
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.48090545
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.41782988
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07381937
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.3337357
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.89215788
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87543560
16CLOCK_20551151_ChIP-Seq_293T_Human1.71293948
17TRIM28_21343339_ChIP-Seq_HEK293_Human1.68639573
18BP1_19119308_ChIP-ChIP_Hs578T_Human1.64466394
19FOXA2_19822575_ChIP-Seq_HepG2_Human1.51984505
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44938758
21TP63_17297297_ChIP-ChIP_HaCaT_Human1.39111840
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38150340
23* HNF4A_19822575_ChIP-Seq_HepG2_Human1.36863910
24HTT_18923047_ChIP-ChIP_STHdh_Human1.33106918
25RXRA_24833708_ChIP-Seq_LIVER_Mouse1.32433237
26DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30505128
27* P68_20966046_ChIP-Seq_HELA_Human1.30152843
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.27763991
29SA1_27219007_Chip-Seq_Bcells_Human1.27285567
30SMC4_20622854_ChIP-Seq_HELA_Human1.27042037
31GATA1_22025678_ChIP-Seq_K562_Human1.21385556
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19223992
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18077429
34TBX20_22328084_ChIP-Seq_HEART_Mouse1.16491684
35TBX20_22080862_ChIP-Seq_HEART_Mouse1.16491684
36SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14932875
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.14796956
38DROSHA_22980978_ChIP-Seq_HELA_Human1.13876757
39SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09028637
40VDR_21846776_ChIP-Seq_THP-1_Human1.06432818
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06102946
42ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05215598
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04533895
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03087534
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02961128
46ZNF263_19887448_ChIP-Seq_K562_Human1.02704478
47E2F1_20622854_ChIP-Seq_HELA_Human1.02310516
48SA1_27219007_Chip-Seq_ERYTHROID_Human1.01725263
49* CREB1_26743006_Chip-Seq_LNCaP_Human0.98920077
50CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98456354
51RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98153457
52TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97271672
53EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95099057
54SOX2_20726797_ChIP-Seq_SW620_Human0.94926917
55* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.93650279
56NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93574286
57EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93403392
58KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92902221
59LXR_22292898_ChIP-Seq_THP-1_Human0.92450137
60* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92383621
61* TCF7_22412390_ChIP-Seq_EML_Mouse0.90941380
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90788453
63TP63_22573176_ChIP-Seq_HFKS_Human0.90371348
64IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.89479771
65UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88667629
66PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88117915
67PHF8_20622854_ChIP-Seq_HELA_Human0.87477012
68SMC3_22415368_ChIP-Seq_MEFs_Mouse0.87145111
69GATA4_25053715_ChIP-Seq_YYC3_Human0.87048258
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86885111
71ESR2_21235772_ChIP-Seq_MCF-7_Human0.86854232
72SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.86675349
73RARA_24833708_ChIP-Seq_LIVER_Mouse0.86579665
74KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85230827
75GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84995838
76YY1_22570637_ChIP-Seq_MALME-3M_Human0.84703370
77SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.84182108
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.83905838
79CTCF_21964334_ChIP-Seq_BJAB-B_Human0.82974989
80ELF1_20517297_ChIP-Seq_JURKAT_Human0.81051605
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.80004910
82RUNX1_27514584_Chip-Seq_MCF-7_Human0.79969984
83RARB_24833708_ChIP-Seq_LIVER_Mouse0.78052260
84STAT3_1855785_ChIP-Seq_MESCs_Mouse0.77357165
85ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77123692
86CDX2_20551321_ChIP-Seq_CACO-2_Human0.76277848
87IRF8_22096565_ChIP-ChIP_GC-B_Human0.75813455
88CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75191775
89RAD21_21589869_ChIP-Seq_MESCs_Mouse0.71575804
90AUTS2_25519132_ChIP-Seq_293T-REX_Human0.70110653
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.69872215
92ERG_21242973_ChIP-ChIP_JURKAT_Human0.68537536
93SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65902716
94PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.65309595
95RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.63278087
96BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61689309
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.61632024
98AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.61563531
99CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.61079131
100KAP1_22055183_ChIP-Seq_ESCs_Mouse0.60011543
101RACK7_27058665_Chip-Seq_MCF-7_Human0.58668249
102CEBPB_22108803_ChIP-Seq_LS180_Human0.57792798
103PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.57401934
104FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.55282194
105EGR1_19032775_ChIP-ChIP_M12_Human0.54190725
106PPAR_26484153_Chip-Seq_NCI-H1993_Human0.54154858
107GATA6_25053715_ChIP-Seq_YYC3_Human0.53918372
108* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.52910824
109BCOR_27268052_Chip-Seq_Bcells_Human0.52304266
110ESET_19884257_ChIP-Seq_ESCs_Mouse0.52024115
111ESR1_20079471_ChIP-ChIP_T-47D_Human0.51414307
112ESR1_21235772_ChIP-Seq_MCF-7_Human0.51201961
113* TET1_21451524_ChIP-Seq_MESCs_Mouse0.50745973
114FOXA1_25552417_ChIP-Seq_VCAP_Human0.48960654
115SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.48727848
116PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.48186293
117SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.47781742
118MYC_19915707_ChIP-ChIP_AK7_Human0.47649325
119GATA1_19941826_ChIP-Seq_K562_Human0.47178287
120SPI1_26923725_Chip-Seq_HPCs_Mouse0.47032619
121FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.47013342
122NRF2_20460467_ChIP-Seq_MEFs_Mouse0.46914655
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.46914655
124MYC_27129775_Chip-Seq_CORNEA_Mouse0.46718035
125FOXO3_23340844_ChIP-Seq_DLD1_Human0.44498746
126GATA1_19941827_ChIP-Seq_MEL_Mouse0.43919973
127FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.43759392
128TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.42790300
129GATA2_19941826_ChIP-Seq_K562_Human0.42535490
130BCL6_27268052_Chip-Seq_Bcells_Human0.42310495
131STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.42229835
132GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.41431858
133CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.41318936
134* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.41210593
135CBP_21632823_ChIP-Seq_H3396_Human0.41195449
136CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.40520838
137POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.40438675
138CTCF_27219007_Chip-Seq_Bcells_Human0.40404118
139TAF2_19829295_ChIP-Seq_ESCs_Human0.40248554
140AR_20517297_ChIP-Seq_VCAP_Human0.39697922
141POU5F1_16518401_ChIP-PET_MESCs_Mouse0.39681358
142* P53_21459846_ChIP-Seq_SAOS-2_Human0.39303644

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.02613605
2MP0005360_urolithiasis7.54365933
3MP0005085_abnormal_gallbladder_physiolo6.35305632
4MP0005365_abnormal_bile_salt6.17214546
5MP0008875_abnormal_xenobiotic_pharmacok5.07532492
6MP0003806_abnormal_nucleotide_metabolis4.13839318
7MP0003252_abnormal_bile_duct3.78233796
8MP0010329_abnormal_lipoprotein_level3.66686876
9MP0009840_abnormal_foam_cell3.34461749
10MP0005083_abnormal_biliary_tract2.95800408
11MP0001666_abnormal_nutrient_absorption2.82363930
12MP0005332_abnormal_amino_acid2.78581814
13MP0000751_myopathy2.60605586
14MP0003195_calcinosis2.54720896
15MP0003191_abnormal_cellular_cholesterol2.40314509
16MP0004019_abnormal_vitamin_homeostasis2.21439754
17MP0002118_abnormal_lipid_homeostasis2.20968056
18MP0000609_abnormal_liver_physiology2.18735263
19MP0003646_muscle_fatigue2.08636603
20MP0004145_abnormal_muscle_electrophysio1.88047470
21MP0005319_abnormal_enzyme/_coenzyme1.83914760
22MP0000749_muscle_degeneration1.80315745
23MP0002138_abnormal_hepatobiliary_system1.75830599
24MP0003868_abnormal_feces_composition1.72407106
25MP0001764_abnormal_homeostasis1.71291439
26MP0004036_abnormal_muscle_relaxation1.67697632
27MP0005584_abnormal_enzyme/coenzyme_acti1.55409993
28MP0000747_muscle_weakness1.47146349
29MP0005330_cardiomyopathy1.40007117
30MP0009697_abnormal_copulation1.39909953
31MP0005451_abnormal_body_composition1.38798847
32MP0003879_abnormal_hair_cell1.38741508
33MP0003183_abnormal_peptide_metabolism1.37872506
34MP0005670_abnormal_white_adipose1.32791157
35MP0003186_abnormal_redox_activity1.32036967
36MP0003705_abnormal_hypodermis_morpholog1.31571161
37MP0004087_abnormal_muscle_fiber1.30024960
38MP0004043_abnormal_pH_regulation1.27600557
39MP0004084_abnormal_cardiac_muscle1.25923793
40MP0003656_abnormal_erythrocyte_physiolo1.25242390
41MP0000013_abnormal_adipose_tissue1.25119469
42MP0009643_abnormal_urine_homeostasis1.24541669
43MP0002332_abnormal_exercise_endurance1.19220945
44MP0003011_delayed_dark_adaptation1.17986864
45MP0000598_abnormal_liver_morphology1.15868324
46MP0010234_abnormal_vibrissa_follicle1.15304925
47MP0005647_abnormal_sex_gland1.14008340
48MP0006138_congestive_heart_failure1.11996798
49MP0002106_abnormal_muscle_physiology1.09991573
50MP0000759_abnormal_skeletal_muscle1.09557692
51MP0004130_abnormal_muscle_cell1.07864972
52MP0002254_reproductive_system_inflammat1.02953215
53MP0004147_increased_porphyrin_level1.02526150
54MP0002971_abnormal_brown_adipose0.98475525
55MP0000003_abnormal_adipose_tissue0.96803659
56MP0000604_amyloidosis0.95918806
57MP0009764_decreased_sensitivity_to0.95402470
58MP0009763_increased_sensitivity_to0.94773750
59MP0006036_abnormal_mitochondrial_physio0.92461939
60MP0005369_muscle_phenotype0.89996375
61MP0005409_darkened_coat_color0.89756197
62MP0005334_abnormal_fat_pad0.85791193
63MP0005620_abnormal_muscle_contractility0.85700138
64MP0009642_abnormal_blood_homeostasis0.85112331
65MP0002876_abnormal_thyroid_physiology0.84519052
66MP0002078_abnormal_glucose_homeostasis0.84053931
67MP0010155_abnormal_intestine_physiology0.83527199
68MP0005376_homeostasis/metabolism_phenot0.83178864
69MP0005636_abnormal_mineral_homeostasis0.82482354
70MP0002972_abnormal_cardiac_muscle0.82274516
71MP0008469_abnormal_protein_level0.80604048
72MP0005385_cardiovascular_system_phenoty0.79649225
73MP0001544_abnormal_cardiovascular_syste0.79649225
74MP0005666_abnormal_adipose_tissue0.79585696
75MP0004215_abnormal_myocardial_fiber0.79546803
76MP0005266_abnormal_metabolism0.77057490
77MP0004510_myositis0.76396375
78MP0002249_abnormal_larynx_morphology0.75410625
79MP0000678_abnormal_parathyroid_gland0.74852049
80MP0005535_abnormal_body_temperature0.74266065
81MP0010630_abnormal_cardiac_muscle0.74094959
82MP0002132_abnormal_respiratory_system0.72854679
83MP0009765_abnormal_xenobiotic_induced0.71289878
84MP0005220_abnormal_exocrine_pancreas0.71289352
85MP0005448_abnormal_energy_balance0.71078733
86MP0005084_abnormal_gallbladder_morpholo0.70122796
87MP0004484_altered_response_of0.69961498
88MP0001661_extended_life_span0.69733062
89MP0003690_abnormal_glial_cell0.68712981
90MP0001765_abnormal_ion_homeostasis0.68233844
91MP0010368_abnormal_lymphatic_system0.67946954
92MP0008775_abnormal_heart_ventricle0.67433874
93MP0005408_hypopigmentation0.67361805
94MP0002837_dystrophic_cardiac_calcinosis0.66747344
95MP0000639_abnormal_adrenal_gland0.63534499
96MP0002796_impaired_skin_barrier0.62168653
97MP0004233_abnormal_muscle_weight0.61529426
98MP0009053_abnormal_anal_canal0.60273490
99MP0009115_abnormal_fat_cell0.60237869
100MP0000750_abnormal_muscle_regeneration0.59595039
101MP0003329_amyloid_beta_deposits0.56650124
102MP0001756_abnormal_urination0.56322597
103MP0001664_abnormal_digestion0.56191090
104MP0000467_abnormal_esophagus_morphology0.55894299
105MP0002127_abnormal_cardiovascular_syste0.55252350
106MP0004858_abnormal_nervous_system0.53657294
107MP0003638_abnormal_response/metabolism_0.51977064
108MP0000579_abnormal_nail_morphology0.49967577
109MP0006035_abnormal_mitochondrial_morpho0.49942945
110MP0002970_abnormal_white_adipose0.49418991
111MP0003718_maternal_effect0.48529412
112MP0004782_abnormal_surfactant_physiolog0.47981094
113MP0005395_other_phenotype0.47890751
114MP0004185_abnormal_adipocyte_glucose0.46706004
115MP0003953_abnormal_hormone_level0.46639301
116MP0008874_decreased_physiological_sensi0.46252834
117MP0005058_abnormal_lysosome_morphology0.44340649
118MP0005464_abnormal_platelet_physiology0.44238687
119MP0002136_abnormal_kidney_physiology0.43456909
120MP0003075_altered_response_to0.43350414
121MP0002822_catalepsy0.42765181
122MP0008873_increased_physiological_sensi0.42665010
123MP0002060_abnormal_skin_morphology0.40175837
124MP0003453_abnormal_keratinocyte_physiol0.39248777
125MP0003724_increased_susceptibility_to0.38492648
126MP0005248_abnormal_Harderian_gland0.37725961
127MP0008872_abnormal_physiological_respon0.35733419
128MP0005375_adipose_tissue_phenotype0.34959343
129MP0002269_muscular_atrophy0.34112501
130MP0004264_abnormal_extraembryonic_tissu0.33694076
131MP0003959_abnormal_lean_body0.33172866
132MP0002928_abnormal_bile_duct0.32963453
133MP0003436_decreased_susceptibility_to0.31381262
134MP0000249_abnormal_blood_vessel0.31178743
135MP0005166_decreased_susceptibility_to0.30976054
136MP0009672_abnormal_birth_weight0.30696974
137MP0006082_CNS_inflammation0.30485436
138MP0002168_other_aberrant_phenotype0.30145089
139MP0001881_abnormal_mammary_gland0.29715411
140MP0001853_heart_inflammation0.29542928
141MP0001243_abnormal_dermal_layer0.27832486
142MP0004381_abnormal_hair_follicle0.27429847

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.25894367
2Intrahepatic cholestasis (HP:0001406)6.98229132
3Deep venous thrombosis (HP:0002625)6.95129712
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.49595069
5Hypobetalipoproteinemia (HP:0003563)6.43448151
6Xanthomatosis (HP:0000991)6.20908812
7Prolonged partial thromboplastin time (HP:0003645)6.04440259
8Hyperlipoproteinemia (HP:0010980)5.48380329
9Complement deficiency (HP:0004431)5.14725346
10Hypolipoproteinemia (HP:0010981)4.84331492
11Hyperammonemia (HP:0001987)4.76273696
12Muscle fiber inclusion bodies (HP:0100299)4.55038532
13Epidermoid cyst (HP:0200040)4.51981782
14Exercise-induced myalgia (HP:0003738)4.48226503
15Nemaline bodies (HP:0003798)4.46403056
16Hyperglycinemia (HP:0002154)4.45293513
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.43998808
18Ketosis (HP:0001946)4.43638868
19Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.41859720
20Joint hemorrhage (HP:0005261)4.38901676
21Abnormality of glutamine family amino acid metabolism (HP:0010902)4.35194161
22Hyperglycinuria (HP:0003108)4.34871701
23Abnormality of sulfur amino acid metabolism (HP:0004339)4.24081209
24Hypoalphalipoproteinemia (HP:0003233)4.21241079
25Abnormality of glycine metabolism (HP:0010895)4.19762032
26Abnormality of serine family amino acid metabolism (HP:0010894)4.19762032
27Abnormality of methionine metabolism (HP:0010901)4.16748331
28Abnormality of aspartate family amino acid metabolism (HP:0010899)4.13619850
29Abnormality of the common coagulation pathway (HP:0010990)4.11702472
30Fat malabsorption (HP:0002630)4.09771518
31Hypoglycemic coma (HP:0001325)3.92022265
32Abnormality of complement system (HP:0005339)3.76024177
33Type 1 muscle fiber predominance (HP:0003803)3.75494662
34Myopathic facies (HP:0002058)3.70315804
35Abnormality of pyrimidine metabolism (HP:0004353)3.67369745
36Hypercholesterolemia (HP:0003124)3.61093790
37Conjugated hyperbilirubinemia (HP:0002908)3.53962391
38Abnormality of fatty-acid metabolism (HP:0004359)3.52998019
39Abnormality of the intrinsic pathway (HP:0010989)3.51846237
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.51617596
41Ketoacidosis (HP:0001993)3.35690393
42Rhabdomyolysis (HP:0003201)3.27412845
43Hyperbilirubinemia (HP:0002904)3.19752658
44Myocardial infarction (HP:0001658)3.12080399
45Hypochromic microcytic anemia (HP:0004840)3.07778965
46Abnormality of nucleobase metabolism (HP:0010932)3.07468054
47Steatorrhea (HP:0002570)3.06938730
48Abnormality of serum amino acid levels (HP:0003112)3.06401929
49Delayed CNS myelination (HP:0002188)3.04326812
50Myoglobinuria (HP:0002913)2.85140883
51Metabolic acidosis (HP:0001942)2.81622950
52Hepatocellular carcinoma (HP:0001402)2.80558475
53Skin nodule (HP:0200036)2.77683427
54Abnormality of purine metabolism (HP:0004352)2.77517209
55Nephritis (HP:0000123)2.74462295
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.72298206
57Dicarboxylic aciduria (HP:0003215)2.72298206
58Lethargy (HP:0001254)2.70100235
59Spontaneous abortion (HP:0005268)2.68676396
60Exercise-induced muscle cramps (HP:0003710)2.68416815
61Asymmetric septal hypertrophy (HP:0001670)2.67745726
62Muscle hypertrophy of the lower extremities (HP:0008968)2.63199408
63Muscle fiber splitting (HP:0003555)2.57987176
64Systemic lupus erythematosus (HP:0002725)2.57393782
65EMG: myopathic abnormalities (HP:0003458)2.57374679
66Centrally nucleated skeletal muscle fibers (HP:0003687)2.56100724
67Distal lower limb muscle weakness (HP:0009053)2.52962406
68Acanthocytosis (HP:0001927)2.49659879
69Gout (HP:0001997)2.49252909
70Hyporeflexia of lower limbs (HP:0002600)2.48724960
71Vascular calcification (HP:0004934)2.48091386
72Increased connective tissue (HP:0009025)2.46777991
73Malnutrition (HP:0004395)2.45093474
74Cerebral edema (HP:0002181)2.43771565
75Spastic diplegia (HP:0001264)2.42962258
76Hypoglycemic seizures (HP:0002173)2.41264087
77Abnormal gallbladder morphology (HP:0012437)2.39603917
78Cholelithiasis (HP:0001081)2.35869061
79Irritability (HP:0000737)2.35713173
80Sudden death (HP:0001699)2.32730040
81Calf muscle hypertrophy (HP:0008981)2.31373236
82Neonatal onset (HP:0003623)2.26805602
83Neck muscle weakness (HP:0000467)2.24364304
84Pancreatitis (HP:0001733)2.23360855
85Abnormality of skeletal muscle fiber size (HP:0012084)2.22651992
86Cholecystitis (HP:0001082)2.21125586
87Abnormal gallbladder physiology (HP:0012438)2.21125586
88Cerebral palsy (HP:0100021)2.21077335
89Glomerulonephritis (HP:0000099)2.20839243
90Ileus (HP:0002595)2.20480618
91Cardiovascular calcification (HP:0011915)2.19640998
92Amyloidosis (HP:0011034)2.18639600
93Mildly elevated creatine phosphokinase (HP:0008180)2.18566447
94Late onset (HP:0003584)2.18563564
95Hyperuricemia (HP:0002149)2.17383016
96Hydroxyprolinuria (HP:0003080)2.16775507
97Abnormality of proline metabolism (HP:0010907)2.16775507
98Brushfield spots (HP:0001088)2.16385264
99Vomiting (HP:0002013)2.16025596
100Opisthotonus (HP:0002179)2.15797654
101Esophageal varix (HP:0002040)2.15484369
102Distal lower limb amyotrophy (HP:0008944)2.14813765
103Mitral stenosis (HP:0001718)2.14404428
104Round ear (HP:0100830)2.14113946
105Muscle stiffness (HP:0003552)2.12691217
106Generalized aminoaciduria (HP:0002909)2.08460121
107Sensorimotor neuropathy (HP:0007141)2.07257070
108Abnormality of the calf musculature (HP:0001430)2.06429147
109Heart block (HP:0012722)2.06417793
110Visceral angiomatosis (HP:0100761)2.05968879
111Hemorrhage of the eye (HP:0011885)2.05866254
112Bundle branch block (HP:0011710)2.04827662
113Recurrent gram-negative bacterial infections (HP:0005420)2.04257556
114Abnormal atrioventricular conduction (HP:0005150)2.03830495
115Atrioventricular block (HP:0001678)2.03607726
116Menorrhagia (HP:0000132)2.02290250
117Difficulty running (HP:0009046)2.01563108
118Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01452842
119Abnormality of alanine metabolism (HP:0010916)2.01452842
120Hyperalaninemia (HP:0003348)2.01452842
121Increased variability in muscle fiber diameter (HP:0003557)1.99905589
122Hyperinsulinemic hypoglycemia (HP:0000825)1.99682935
123Ventricular tachycardia (HP:0004756)1.99098888
124Poikilocytosis (HP:0004447)1.97529279
125Bulbar palsy (HP:0001283)1.96112893
126Distal arthrogryposis (HP:0005684)1.95445693
127Abnormal cartilage morphology (HP:0002763)1.94939497
128Gingival bleeding (HP:0000225)1.94257951
129Enlarged kidneys (HP:0000105)1.94198828
130Abnormality of the Achilles tendon (HP:0005109)1.94087166
131Abnormality of the gallbladder (HP:0005264)1.91937865
132Spontaneous hematomas (HP:0007420)1.88614264
133Nausea (HP:0002018)1.87939145
134Hypertriglyceridemia (HP:0002155)1.87493563
135Increased serum pyruvate (HP:0003542)1.87331386
136Thrombophlebitis (HP:0004418)1.86198508
137Acute hepatic failure (HP:0006554)1.85817126
138Turricephaly (HP:0000262)1.84742270
139Abnormality of transition element cation homeostasis (HP:0011030)1.83223787
140Abnormality of iron homeostasis (HP:0011031)1.82589817
141Rickets (HP:0002748)1.81951331
142Abnormal enzyme/coenzyme activity (HP:0012379)1.81236253
143Renal cortical cysts (HP:0000803)1.80964108
144Alkalosis (HP:0001948)1.79688511
145Elevated hepatic transaminases (HP:0002910)1.78858487
146Hyperglycemia (HP:0003074)1.78518134
147Increased purine levels (HP:0004368)1.77231701

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.86540290
2OBSCN5.01013013
3SIK14.63569429
4ERN14.03184762
5FGFR43.78743852
6TTN3.76526505
7INSRR2.50721728
8TRIB32.39510600
9ERBB42.29199154
10TAOK32.24417972
11MAPK152.18419097
12MST1R2.17943152
13PINK12.11610641
14ACVR1B2.11105977
15ICK2.09994164
16PIK3CA2.00030125
17MAPK111.98833187
18PKN21.94556322
19PRPF4B1.75221545
20MAP2K41.72762907
21FLT31.66212290
22MAP3K111.63606409
23MAP3K61.62180859
24EPHA21.59809955
25LATS11.56432027
26EEF2K1.51636998
27EPHB21.48962282
28PIK3CG1.45828580
29PRKAA21.36270394
30FRK1.34621488
31LMTK21.31071479
32TYK21.30661188
33PTK61.27590650
34MAPKAPK31.27045315
35CAMK1D1.23262317
36MAP3K101.21218157
37CSK1.21176554
38CDK61.18172167
39FGFR21.16737785
40PRKG21.16323486
41DYRK1B1.13909482
42ABL21.13353760
43JAK21.11176797
44MAP3K71.11135469
45DDR21.08123296
46DAPK21.05209835
47RIPK11.02006676
48MUSK1.01232463
49MAP3K10.99848462
50NEK90.99619513
51MYLK0.97894747
52KDR0.96380255
53CDC42BPA0.95138585
54PRKAA10.93530062
55GSK3A0.92847780
56MAPK40.92742321
57GRK60.91623162
58MAP2K30.90123499
59BMX0.87538885
60MET0.84600171
61TBK10.83362113
62PRKCZ0.82982808
63MAP3K30.81355167
64STK38L0.79113249
65JAK30.78430814
66PDGFRA0.78228929
67JAK10.77682717
68SMG10.77202305
69ERBB20.76182382
70CAMK2G0.76054144
71CAMK2D0.75996766
72PRKACG0.74606367
73TAOK10.73109923
74PDK30.72458025
75PDK40.72458025
76EPHB10.69507717
77SGK4940.69040494
78SGK2230.69040494
79MAPK120.66547309
80TESK10.66292832
81CDK90.65523880
82MAP4K10.65112134
83TIE10.61530528
84DMPK0.61218949
85MATK0.61130649
86TYRO30.59508561
87MAP3K130.59498431
88RPS6KB20.59253913
89KSR20.58144788
90IRAK30.57902294
91TRPM70.56819294
92ZAP700.56134284
93MAP2K60.56042364
94RPS6KL10.54001435
95RPS6KC10.54001435
96MTOR0.53439967
97TAOK20.52994406
98SGK30.52264687
99PDPK10.51470506
100PTK20.51196305
101BLK0.50867954
102CAMK1G0.49616397
103AKT30.48916293
104SGK20.47716502
105DAPK10.46981299
106TNK20.46100633
107AKT20.45895304
108LATS20.45718402
109NTRK30.45169517
110CAMK2B0.45037165
111FGFR30.43672329
112CSNK1G10.42756241
113PHKG10.42339211
114PHKG20.42339211
115MAP3K140.41938881
116CDK40.41751068
117RPS6KA20.41043124
118RPS6KA60.40533519
119NME10.40210483
120MAP2K10.40142925
121TGFBR20.38598491
122PRKG10.37631611
123FGR0.37596602
124PRKACA0.36324465
125MAP2K20.36041536
126SGK10.35896264
127MAPK70.35853885
128EGFR0.34893573
129EPHA30.34876572
130ROCK10.33571700
131MAP3K50.32803409
132PDK20.29447426
133IGF1R0.29074272
134PRKCQ0.28503246
135CSF1R0.27519492
136IKBKE0.27443867
137PRKD10.27142452
138PDK10.26765576
139MAPK30.25222701
140PRKD20.24467158
141GRK10.21843442
142ABL10.21653543
143RPS6KA10.21399926
144FGFR10.21104740
145CAMK40.21015233

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.29719218
2Nitrogen metabolism_Homo sapiens_hsa009103.54402667
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.24526315
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.24497610
5* Arginine biosynthesis_Homo sapiens_hsa002202.88162580
6Tryptophan metabolism_Homo sapiens_hsa003802.64601465
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62034194
8Fatty acid degradation_Homo sapiens_hsa000712.58877831
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.55799386
10Complement and coagulation cascades_Homo sapiens_hsa046102.52597813
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50650612
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.49924946
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.27365271
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.13617797
15Propanoate metabolism_Homo sapiens_hsa006402.10387931
16Butanoate metabolism_Homo sapiens_hsa006502.08339376
17Peroxisome_Homo sapiens_hsa041462.07047774
18Fatty acid metabolism_Homo sapiens_hsa012122.02212123
19PPAR signaling pathway_Homo sapiens_hsa033202.01052458
20Chemical carcinogenesis_Homo sapiens_hsa052041.91786414
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.91450706
22Histidine metabolism_Homo sapiens_hsa003401.88314531
23Caffeine metabolism_Homo sapiens_hsa002321.87049670
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.80535140
25beta-Alanine metabolism_Homo sapiens_hsa004101.75984048
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.70222239
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65632669
28Retinol metabolism_Homo sapiens_hsa008301.65256614
29Staphylococcus aureus infection_Homo sapiens_hsa051501.60978553
30Phenylalanine metabolism_Homo sapiens_hsa003601.57850289
31* Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.54110930
32Selenocompound metabolism_Homo sapiens_hsa004501.51942705
33Bile secretion_Homo sapiens_hsa049761.47567721
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47323434
35* 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47009244
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45986491
37Fat digestion and absorption_Homo sapiens_hsa049751.44889530
38Pyruvate metabolism_Homo sapiens_hsa006201.44538211
39Tyrosine metabolism_Homo sapiens_hsa003501.43608912
40Fatty acid elongation_Homo sapiens_hsa000621.38328201
41Sulfur metabolism_Homo sapiens_hsa009201.36798686
42Starch and sucrose metabolism_Homo sapiens_hsa005001.36760616
43Folate biosynthesis_Homo sapiens_hsa007901.35233375
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.29051567
45* Biosynthesis of amino acids_Homo sapiens_hsa012301.24575668
46ABC transporters_Homo sapiens_hsa020101.20248564
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18148116
48* Carbon metabolism_Homo sapiens_hsa012001.16061587
49Steroid biosynthesis_Homo sapiens_hsa001001.13416029
50Fatty acid biosynthesis_Homo sapiens_hsa000611.11727861
51Arginine and proline metabolism_Homo sapiens_hsa003301.08121508
52Sulfur relay system_Homo sapiens_hsa041221.03471365
53Maturity onset diabetes of the young_Homo sapiens_hsa049501.01556074
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.99701477
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99357173
56Vitamin digestion and absorption_Homo sapiens_hsa049770.93176083
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89994703
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89467938
59Vitamin B6 metabolism_Homo sapiens_hsa007500.88783528
60Glycerolipid metabolism_Homo sapiens_hsa005610.85981786
61Lysine degradation_Homo sapiens_hsa003100.85710087
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75173769
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72900733
64Other glycan degradation_Homo sapiens_hsa005110.72568757
65Glutathione metabolism_Homo sapiens_hsa004800.72186694
66One carbon pool by folate_Homo sapiens_hsa006700.63792675
67Pentose phosphate pathway_Homo sapiens_hsa000300.59249790
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50395326
69* Metabolic pathways_Homo sapiens_hsa011000.47210974
70Fructose and mannose metabolism_Homo sapiens_hsa000510.38263108
71Galactose metabolism_Homo sapiens_hsa000520.36231330
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31678676
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.30761450
74Pertussis_Homo sapiens_hsa051330.29655079
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28577122
76Linoleic acid metabolism_Homo sapiens_hsa005910.28327090
77Insulin resistance_Homo sapiens_hsa049310.27659931
78Prion diseases_Homo sapiens_hsa050200.27460435
79Dilated cardiomyopathy_Homo sapiens_hsa054140.24546468
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.22327520
81AMPK signaling pathway_Homo sapiens_hsa041520.14580994
82Glucagon signaling pathway_Homo sapiens_hsa049220.13053251
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.10837912
84Cardiac muscle contraction_Homo sapiens_hsa042600.10190567
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.08760257
86Renin secretion_Homo sapiens_hsa049240.08211961
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.06973622
88Amoebiasis_Homo sapiens_hsa051460.05438253
89Pancreatic secretion_Homo sapiens_hsa049720.04320089
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.03023471
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.02463589
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.01626382
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2106951
94Hepatitis C_Homo sapiens_hsa05160-0.2031878
95African trypanosomiasis_Homo sapiens_hsa05143-0.1999523
96Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1988275
97Regulation of autophagy_Homo sapiens_hsa04140-0.1906791
98Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1906276
99Bladder cancer_Homo sapiens_hsa05219-0.1855347
100Protein digestion and absorption_Homo sapiens_hsa04974-0.1854065
101Circadian rhythm_Homo sapiens_hsa04710-0.1774920
102Mineral absorption_Homo sapiens_hsa04978-0.1615174
103Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1534960
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1526129
105Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1269718
106Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1172714
107Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1134067
108Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1104565
109Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1035401
110Renin-angiotensin system_Homo sapiens_hsa04614-0.0213605
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412-0.0182624
112Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0115325
113Insulin signaling pathway_Homo sapiens_hsa04910-0.0097403
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261-0.0024688

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