GPSM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82). Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retinal cone cell development (GO:0046549)8.17229641
2detection of light stimulus involved in sensory perception (GO:0050962)6.95187399
3detection of light stimulus involved in visual perception (GO:0050908)6.95187399
4nuclear pore complex assembly (GO:0051292)6.41502323
5photoreceptor cell maintenance (GO:0045494)6.33078551
6photoreceptor cell development (GO:0042461)6.18625120
7eye photoreceptor cell development (GO:0042462)6.02646580
8phototransduction, visible light (GO:0007603)5.84406801
9detection of visible light (GO:0009584)5.70461158
10phototransduction (GO:0007602)5.65975219
11detection of light stimulus (GO:0009583)5.60132965
12positive regulation of guanylate cyclase activity (GO:0031284)5.57604684
13GMP metabolic process (GO:0046037)5.45905441
14eye photoreceptor cell differentiation (GO:0001754)5.17802169
15photoreceptor cell differentiation (GO:0046530)5.17802169
16retinal rod cell development (GO:0046548)5.13904582
17regulation of guanylate cyclase activity (GO:0031282)5.07423622
18cellular response to light stimulus (GO:0071482)4.85950636
19regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.73519541
20pore complex assembly (GO:0046931)4.72364029
21visual perception (GO:0007601)4.61307513
22sensory perception of light stimulus (GO:0050953)4.61126370
23sister chromatid segregation (GO:0000819)4.55409436
24mitotic sister chromatid segregation (GO:0000070)4.38530474
25protein-chromophore linkage (GO:0018298)4.37359617
26kinetochore organization (GO:0051383)4.36941076
27mitotic chromosome condensation (GO:0007076)4.28568343
28protein localization to kinetochore (GO:0034501)4.19681945
29retina development in camera-type eye (GO:0060041)4.11227142
30regulation of centriole replication (GO:0046599)4.05256827
31protein localization to chromosome, centromeric region (GO:0071459)4.01430287
32regulation of cGMP metabolic process (GO:0030823)3.99862558
33DNA unwinding involved in DNA replication (GO:0006268)3.85833276
34detection of external stimulus (GO:0009581)3.76167456
35DNA packaging (GO:0006323)3.74192822
36regulation of sister chromatid cohesion (GO:0007063)3.73736286
37regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.73323801
38detection of abiotic stimulus (GO:0009582)3.70802178
39regulation of centrosome cycle (GO:0046605)3.65364421
40kinetochore assembly (GO:0051382)3.65135702
41nuclear envelope disassembly (GO:0051081)3.65125447
42membrane disassembly (GO:0030397)3.65125447
43attachment of spindle microtubules to kinetochore (GO:0008608)3.65084970
44DNA replication-dependent nucleosome organization (GO:0034723)3.55967390
45DNA replication-dependent nucleosome assembly (GO:0006335)3.55967390
46positive regulation of chromosome segregation (GO:0051984)3.52779435
47hemidesmosome assembly (GO:0031581)3.52603494
48regulation of spindle organization (GO:0090224)3.51719658
49cellular response to radiation (GO:0071478)3.50022982
50regulation of mitotic spindle organization (GO:0060236)3.49914132
51regulation of chromosome segregation (GO:0051983)3.47243316
52cytoskeleton-dependent cytokinesis (GO:0061640)3.45572987
53mitotic metaphase plate congression (GO:0007080)3.43550588
54positive regulation of cell cycle checkpoint (GO:1901978)3.39640771
55CENP-A containing nucleosome assembly (GO:0034080)3.36206759
56DNA duplex unwinding (GO:0032508)3.30217192
57DNA conformation change (GO:0071103)3.29104542
58chromatin remodeling at centromere (GO:0031055)3.27777403
59positive regulation of cGMP metabolic process (GO:0030825)3.27304196
60spindle assembly involved in mitosis (GO:0090307)3.26956157
61protoporphyrinogen IX metabolic process (GO:0046501)3.26829727
62positive regulation of mitotic sister chromatid separation (GO:1901970)3.25614447
63positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.25614447
64positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.25614447
65mitotic spindle organization (GO:0007052)3.23497045
66spindle checkpoint (GO:0031577)3.23353488
67regulation of centrosome duplication (GO:0010824)3.23300577
68spindle assembly checkpoint (GO:0071173)3.22773808
69metaphase plate congression (GO:0051310)3.21187568
70DNA geometric change (GO:0032392)3.19400226
71spindle organization (GO:0007051)3.16557271
72negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.15416953
73negative regulation of sister chromatid segregation (GO:0033046)3.15416953
74negative regulation of mitotic sister chromatid separation (GO:2000816)3.15416953
75negative regulation of mitotic sister chromatid segregation (GO:0033048)3.15416953
76positive regulation of cGMP biosynthetic process (GO:0030828)3.15144376
77* establishment of mitotic spindle localization (GO:0040001)3.14410969
78regulation of mitotic metaphase/anaphase transition (GO:0030071)3.14219108
79negative regulation of chromosome segregation (GO:0051985)3.12855556
80mitotic spindle assembly checkpoint (GO:0007094)3.10966610
81protein heterotetramerization (GO:0051290)3.10936893
82regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.06477091
83protoporphyrinogen IX biosynthetic process (GO:0006782)3.06455415
84microtubule polymerization or depolymerization (GO:0031109)3.05970552
85negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.05362642
86heterochromatin organization (GO:0070828)3.04678712
87desmosome organization (GO:0002934)3.04163254
88DNA strand elongation (GO:0022616)3.03683090
89mitotic sister chromatid cohesion (GO:0007064)3.03262192
90telomere maintenance via semi-conservative replication (GO:0032201)3.02589586
91histone-serine phosphorylation (GO:0035404)3.01319088
92mitotic spindle checkpoint (GO:0071174)3.00151429
93chromosome condensation (GO:0030261)2.98967647
94spindle assembly (GO:0051225)2.98311439
95regulation of cGMP biosynthetic process (GO:0030826)2.97948189
96DNA replication initiation (GO:0006270)2.97860944
97establishment of chromosome localization (GO:0051303)2.97506771
98nuclear envelope organization (GO:0006998)2.96674034
99histone exchange (GO:0043486)2.96201221
100DNA replication-independent nucleosome assembly (GO:0006336)2.96157574
101DNA replication-independent nucleosome organization (GO:0034724)2.96157574
102nonmotile primary cilium assembly (GO:0035058)2.96114932
103detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.92341371
104microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.91832965
105regulation of sister chromatid segregation (GO:0033045)2.91023662
106regulation of mitotic sister chromatid separation (GO:0010965)2.91023662
107regulation of mitotic sister chromatid segregation (GO:0033047)2.91023662
108DNA topological change (GO:0006265)2.90424802
109interkinetic nuclear migration (GO:0022027)2.88375723
110centrosome duplication (GO:0051298)2.87437640
111negative regulation of DNA repair (GO:0045738)2.87200263
112non-recombinational repair (GO:0000726)2.84911374
113double-strand break repair via nonhomologous end joining (GO:0006303)2.84911374
114DNA ligation (GO:0006266)2.84130554
115* establishment of spindle localization (GO:0051293)2.82262506
116nuclear pore organization (GO:0006999)2.81143601
117peptidyl-lysine dimethylation (GO:0018027)2.80288012
118telomere maintenance via recombination (GO:0000722)2.80193106
119protein localization to chromosome (GO:0034502)2.79709313
120regulation of RNA export from nucleus (GO:0046831)2.79480571
121mitotic nuclear envelope disassembly (GO:0007077)2.78594330
122DNA strand elongation involved in DNA replication (GO:0006271)2.78591200
123regulation of DNA endoreduplication (GO:0032875)2.78340143
124chromosome segregation (GO:0007059)2.77929049
125mitotic recombination (GO:0006312)2.76125888
126prenylation (GO:0097354)2.75681150
127protein prenylation (GO:0018342)2.75681150
128mitotic G2 DNA damage checkpoint (GO:0007095)2.73917916
129cell morphogenesis involved in neuron differentiation (GO:0048667)2.73732796
130regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.73461297
131meiotic chromosome segregation (GO:0045132)2.73344513
132negative regulation of cell cycle G2/M phase transition (GO:1902750)2.72636070
133DNA synthesis involved in DNA repair (GO:0000731)2.72354802
134microtubule depolymerization (GO:0007019)2.71744032
135histone phosphorylation (GO:0016572)2.71680497
136mitotic G2/M transition checkpoint (GO:0044818)2.69841441
137cytokinesis (GO:0000910)2.66230840
138mitotic cytokinesis (GO:0000281)2.65690388
139positive regulation of cytokinesis (GO:0032467)2.65159564
140chromosome organization (GO:0051276)2.64437780
141DNA replication checkpoint (GO:0000076)2.63745602
142mitotic nuclear division (GO:0007067)2.63459819
143mitotic cell cycle (GO:0000278)2.62288800
144regulation of exit from mitosis (GO:0007096)2.61047388
145regulation of rhodopsin mediated signaling pathway (GO:0022400)10.1962707
146rhodopsin mediated signaling pathway (GO:0016056)10.1461200

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human8.90759930
2E2F7_22180533_ChIP-Seq_HELA_Human8.29046993
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.80571182
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.76486336
5E2F4_17652178_ChIP-ChIP_JURKAT_Human4.49412730
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.28825099
7AR_21909140_ChIP-Seq_LNCAP_Human4.01087103
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.23421593
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.62340016
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.30153473
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.21058698
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15951791
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.09256663
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.06779180
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.05266542
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.04567378
17* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95570614
18MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93785046
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.92270507
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.89290773
21* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.88071047
22MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87042722
23XRN2_22483619_ChIP-Seq_HELA_Human1.86109360
24HIF1A_21447827_ChIP-Seq_MCF-7_Human1.82552830
25GATA1_22025678_ChIP-Seq_K562_Human1.71092758
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.68980794
27MYC_19030024_ChIP-ChIP_MESCs_Mouse1.64969731
28ZNF263_19887448_ChIP-Seq_K562_Human1.63054453
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.61384789
30DCP1A_22483619_ChIP-Seq_HELA_Human1.60703716
31CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.59013478
32ESR1_15608294_ChIP-ChIP_MCF-7_Human1.56028823
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55290125
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.46802327
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41718440
36SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.38722667
37SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.38722667
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36629702
39PKCTHETA_26484144_Chip-Seq_BREAST_Human1.36327757
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34794298
41TTF2_22483619_ChIP-Seq_HELA_Human1.28386575
42KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.27336959
43* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27125824
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26920845
45SOX2_16153702_ChIP-ChIP_HESCs_Human1.26637873
46CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25862880
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.23606255
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21729613
49* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18287416
50* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17669043
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17425940
52FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.17373795
53BRD4_25478319_ChIP-Seq_HGPS_Human1.16117080
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16045074
55CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15810116
56CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.15776629
57GABP_17652178_ChIP-ChIP_JURKAT_Human1.13242612
58ELK1_19687146_ChIP-ChIP_HELA_Human1.12091709
59SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11806832
60KDM5A_27292631_Chip-Seq_BREAST_Human1.11596777
61YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11327904
62CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10802232
63TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10714176
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06834613
65MYC_18940864_ChIP-ChIP_HL60_Human1.06153017
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04203092
67VDR_23849224_ChIP-Seq_CD4+_Human1.03028716
68* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.02301270
69FOXP3_21729870_ChIP-Seq_TREG_Human1.01668821
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00923655
71EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.00557487
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98705835
73FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97513729
74NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97369226
75CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96751322
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.95220252
77SOX9_26525672_Chip-Seq_HEART_Mouse0.94709397
78NANOG_16153702_ChIP-ChIP_HESCs_Human0.94287215
79TP63_19390658_ChIP-ChIP_HaCaT_Human0.94137211
80ESR1_20079471_ChIP-ChIP_T-47D_Human0.92676112
81* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.92666075
82FUS_26573619_Chip-Seq_HEK293_Human0.92660171
83WT1_19549856_ChIP-ChIP_CCG9911_Human0.91947068
84TRIM28_21343339_ChIP-Seq_HEK293_Human0.91782229
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90543877
86NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90506479
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89982919
88KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89910413
89* CHD1_26751641_Chip-Seq_LNCaP_Human0.89526381
90* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88422272
91JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.88026086
92DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87758693
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86366972
94GATA6_25053715_ChIP-Seq_YYC3_Human0.86245186
95* UBF1/2_26484160_Chip-Seq_HMECs_Human0.85992674
96GABP_19822575_ChIP-Seq_HepG2_Human0.85943901
97GATA4_21415370_ChIP-Seq_HL-1_Mouse0.83336458
98VDR_22108803_ChIP-Seq_LS180_Human0.83010797
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.82986358
100THAP11_20581084_ChIP-Seq_MESCs_Mouse0.82654891
101P300_27058665_Chip-Seq_ZR-75-30cells_Human0.82443316
102HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.82296618
103HOXB4_20404135_ChIP-ChIP_EML_Mouse0.81996338
104SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.80755808
105ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.80585546
106SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.79305343
107FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.78932224
108NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.78671578
109NANOG_18555785_ChIP-Seq_MESCs_Mouse0.78562277
110HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.78105347
111SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.77588448
112NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.76831624
113FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.76146539
114* SOX17_20123909_ChIP-Seq_XEN_Mouse0.75253534
115PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.75245437
116EGR1_23403033_ChIP-Seq_LIVER_Mouse0.75244135
117* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.74632484
118ELF1_17652178_ChIP-ChIP_JURKAT_Human0.74537407
119* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.74513272
120SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74208408
121* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.74179982
122POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.73801640
123SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.72320175
124SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.72119161
125PPAR_26484153_Chip-Seq_NCI-H1993_Human0.71818919
126TP53_16413492_ChIP-PET_HCT116_Human0.71583095
127* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.71160512
128BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.70930774
129CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70572779
130CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.70003361
131CLOCK_20551151_ChIP-Seq_293T_Human0.69748875
132TCF3_18692474_ChIP-Seq_MEFs_Mouse0.69675370
133POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.69170443
134EWS_26573619_Chip-Seq_HEK293_Human0.68428148
135HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.68066619
136ATF3_27146783_Chip-Seq_COLON_Human0.67967493
137RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.67545473
138* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.67336037
139* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.66839011
140HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.63460259
141CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.63230154
142* NANOG_21062744_ChIP-ChIP_HESCs_Human0.63095569

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation6.48070785
2MP0005551_abnormal_eye_electrophysiolog6.10482041
3MP0005253_abnormal_eye_physiology4.12741656
4MP0006072_abnormal_retinal_apoptosis3.90340159
5MP0003950_abnormal_plasma_membrane3.86284028
6MP0010030_abnormal_orbit_morphology2.86457100
7MP0005195_abnormal_posterior_eye2.67651565
8MP0002877_abnormal_melanocyte_morpholog2.62669978
9MP0005391_vision/eye_phenotype2.52699608
10MP0003111_abnormal_nucleus_morphology2.40764579
11MP0001324_abnormal_eye_pigmentation2.32776451
12MP0003705_abnormal_hypodermis_morpholog2.25992664
13MP0010234_abnormal_vibrissa_follicle2.17382559
14MP0009697_abnormal_copulation1.94033189
15MP0008438_abnormal_cutaneous_collagen1.87992714
16MP0003077_abnormal_cell_cycle1.87552941
17MP0010094_abnormal_chromosome_stability1.87513980
18MP0002009_preneoplasia1.83106682
19MP0003693_abnormal_embryo_hatching1.78495757
20MP0010678_abnormal_skin_adnexa1.77830824
21MP0000383_abnormal_hair_follicle1.77504490
22MP0004957_abnormal_blastocyst_morpholog1.71146499
23MP0000647_abnormal_sebaceous_gland1.68511953
24MP0005275_abnormal_skin_tensile1.65907471
25MP0002090_abnormal_vision1.65014657
26MP0000537_abnormal_urethra_morphology1.59198569
27MP0008789_abnormal_olfactory_epithelium1.59060151
28MP0002396_abnormal_hematopoietic_system1.54926940
29MP0005409_darkened_coat_color1.41819893
30MP0008007_abnormal_cellular_replicative1.40491239
31MP0009053_abnormal_anal_canal1.38314222
32MP0004185_abnormal_adipocyte_glucose1.37774687
33MP0000566_synostosis1.37198024
34MP0000377_abnormal_hair_follicle1.34424976
35MP0005501_abnormal_skin_physiology1.34293987
36MP0008932_abnormal_embryonic_tissue1.33317182
37MP0000569_abnormal_digit_pigmentation1.33063292
38MP0003937_abnormal_limbs/digits/tail_de1.31930274
39MP0008058_abnormal_DNA_repair1.29546865
40MP0002282_abnormal_trachea_morphology1.27636891
41MP0003566_abnormal_cell_adhesion1.27105808
42MP0006054_spinal_hemorrhage1.25821953
43MP0001730_embryonic_growth_arrest1.24473410
44MP0000762_abnormal_tongue_morphology1.23036932
45MP0004808_abnormal_hematopoietic_stem1.22165651
46MP0009384_cardiac_valve_regurgitation1.21804011
47MP0003984_embryonic_growth_retardation1.21322901
48MP0000462_abnormal_digestive_system1.20155661
49MP0008057_abnormal_DNA_replication1.19460297
50MP0002098_abnormal_vibrissa_morphology1.18896158
51MP0002796_impaired_skin_barrier1.18737602
52MP0000579_abnormal_nail_morphology1.17811029
53MP0001243_abnormal_dermal_layer1.16465187
54MP0003656_abnormal_erythrocyte_physiolo1.15396192
55MP0002088_abnormal_embryonic_growth/wei1.14718645
56MP0000350_abnormal_cell_proliferation1.13116370
57MP0002086_abnormal_extraembryonic_tissu1.12283708
58MP0005394_taste/olfaction_phenotype1.11456645
59MP0005499_abnormal_olfactory_system1.11456645
60MP0001299_abnormal_eye_distance/1.10939808
61MP0001293_anophthalmia1.10854323
62MP0001286_abnormal_eye_development1.09713516
63MP0002638_abnormal_pupillary_reflex1.09522785
64MP0009250_abnormal_appendicular_skeleto1.08782001
65MP0000428_abnormal_craniofacial_morphol1.07360079
66MP0000749_muscle_degeneration1.06668125
67MP0000427_abnormal_hair_cycle1.06506300
68MP0010352_gastrointestinal_tract_polyps1.06374629
69MP0000467_abnormal_esophagus_morphology1.05013399
70MP0002752_abnormal_somatic_nervous1.04225880
71MP0005360_urolithiasis1.03747161
72MP0003786_premature_aging1.03447730
73MP0002697_abnormal_eye_size1.03014734
74MP0002229_neurodegeneration1.00627280
75MP0002060_abnormal_skin_morphology1.00370923
76MP0010307_abnormal_tumor_latency0.99441407
77MP0002092_abnormal_eye_morphology0.99023159
78MP0005187_abnormal_penis_morphology0.97645090
79* MP0005621_abnormal_cell_physiology0.96749106
80MP0005503_abnormal_tendon_morphology0.96426054
81MP0003123_paternal_imprinting0.95393622
82MP0002234_abnormal_pharynx_morphology0.94962398
83MP0004147_increased_porphyrin_level0.94943914
84MP0001764_abnormal_homeostasis0.94214830
85MP0003755_abnormal_palate_morphology0.94103857
86MP0003453_abnormal_keratinocyte_physiol0.93682177
87MP0001346_abnormal_lacrimal_gland0.92803784
88MP0002233_abnormal_nose_morphology0.92414871
89MP0000013_abnormal_adipose_tissue0.92263250
90MP0000003_abnormal_adipose_tissue0.92135918
91MP0002269_muscular_atrophy0.91567488
92MP0005171_absent_coat_pigmentation0.91223440
93MP0004233_abnormal_muscle_weight0.91110014
94MP0003385_abnormal_body_wall0.90528644
95MP0000049_abnormal_middle_ear0.89615101
96MP0005197_abnormal_uvea_morphology0.89037049
97MP0004197_abnormal_fetal_growth/weight/0.87874553
98MP0001216_abnormal_epidermal_layer0.86371216
99MP0004264_abnormal_extraembryonic_tissu0.86349231
100MP0003890_abnormal_embryonic-extraembry0.85755118
101MP0002085_abnormal_embryonic_tissue0.85470606
102MP0000313_abnormal_cell_death0.85231093
103MP0003718_maternal_effect0.85006837
104MP0005023_abnormal_wound_healing0.82967053
105MP0003935_abnormal_craniofacial_develop0.82451336
106* MP0005076_abnormal_cell_differentiation0.81711640
107MP0004134_abnormal_chest_morphology0.80913835
108MP0003941_abnormal_skin_development0.80622911
109MP0003115_abnormal_respiratory_system0.80306870
110MP0002102_abnormal_ear_morphology0.79874657
111MP0000627_abnormal_mammary_gland0.79691805
112MP0001849_ear_inflammation0.78738030
113MP0001697_abnormal_embryo_size0.78595462
114MP0000733_abnormal_muscle_development0.78205907
115MP0002095_abnormal_skin_pigmentation0.77340840
116MP0001191_abnormal_skin_condition0.76809442
117* MP0005384_cellular_phenotype0.76360528
118MP0009931_abnormal_skin_appearance0.75689742
119MP0010771_integument_phenotype0.74992349
120MP0002114_abnormal_axial_skeleton0.74639675
121MP0002111_abnormal_tail_morphology0.74361218
122MP0009780_abnormal_chondrocyte_physiolo0.73335096
123MP0003943_abnormal_hepatobiliary_system0.72925180
124MP0002084_abnormal_developmental_patter0.71664673
125MP0001340_abnormal_eyelid_morphology0.69384322
126MP0001348_abnormal_lacrimal_gland0.68912865
127MP0003806_abnormal_nucleotide_metabolis0.68480341
128MP0003315_abnormal_perineum_morphology0.68230058
129MP0000759_abnormal_skeletal_muscle0.67717738
130MP0004381_abnormal_hair_follicle0.67304034
131MP0000432_abnormal_head_morphology0.66811358
132MP0002932_abnormal_joint_morphology0.65593966
133MP0005380_embryogenesis_phenotype0.64673492
134MP0001672_abnormal_embryogenesis/_devel0.64673492
135MP0002080_prenatal_lethality0.64268594
136MP0002249_abnormal_larynx_morphology0.64038433
137MP0001915_intracranial_hemorrhage0.63968924

Predicted human phenotypes

RankGene SetZ-score
1Bony spicule pigmentary retinopathy (HP:0007737)8.37503415
2Chorioretinal atrophy (HP:0000533)7.33701114
3Pigmentary retinal degeneration (HP:0001146)6.90255256
4Abnormal rod and cone electroretinograms (HP:0008323)6.75551419
5Pendular nystagmus (HP:0012043)6.11318308
6Absent rod-and cone-mediated responses on ERG (HP:0007688)6.01057412
7Attenuation of retinal blood vessels (HP:0007843)5.25287932
8Abnormality of macular pigmentation (HP:0008002)5.00530186
9Increased corneal curvature (HP:0100692)4.84765986
10Keratoconus (HP:0000563)4.84765986
11Dyschromatopsia (HP:0007641)4.84055887
12Central scotoma (HP:0000603)4.83483420
13Vitreoretinal degeneration (HP:0000655)4.74943486
14Scotoma (HP:0000575)4.59594932
15Chromosomal breakage induced by crosslinking agents (HP:0003221)4.42121397
16Chromsome breakage (HP:0040012)4.30758654
17Type II diabetes mellitus (HP:0005978)4.15403489
18Photophobia (HP:0000613)3.98305883
19Decreased central vision (HP:0007663)3.89717388
20Abolished electroretinogram (ERG) (HP:0000550)3.77830770
21Cone-rod dystrophy (HP:0000548)3.67686172
22Retinitis pigmentosa (HP:0000510)3.27810828
23Deep philtrum (HP:0002002)3.23408029
24Severe visual impairment (HP:0001141)3.21014089
25Macular degeneration (HP:0000608)3.07326234
26Abnormal auditory evoked potentials (HP:0006958)3.02241778
27Choroideremia (HP:0001139)2.88612823
28Ankyloglossia (HP:0010296)2.83280993
29Missing ribs (HP:0000921)2.58482343
30Posterior subcapsular cataract (HP:0007787)2.58206467
3111 pairs of ribs (HP:0000878)2.53406015
32Cystic hygroma (HP:0000476)2.48242406
33Poikiloderma (HP:0001029)2.44698125
34Sandal gap (HP:0001852)2.38573969
35Premature rupture of membranes (HP:0001788)2.36323909
36Nephroblastoma (Wilms tumor) (HP:0002667)2.36019093
37Abnormality of chromosome stability (HP:0003220)2.33541229
38Insidious onset (HP:0003587)2.27139744
39Termporal pattern (HP:0011008)2.27139744
40Abnormality of the preputium (HP:0100587)2.24957804
41Cortical dysplasia (HP:0002539)2.20355983
42Embryonal renal neoplasm (HP:0011794)2.19725260
43Abnormality of oral frenula (HP:0000190)2.19275508
44Microglossia (HP:0000171)2.18924043
45Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.17015931
46Entropion (HP:0000621)2.13927319
47Osteolytic defects of the phalanges of the hand (HP:0009771)2.13578097
48Osteolytic defects of the hand bones (HP:0009699)2.13578097
49Constricted visual fields (HP:0001133)2.12206601
50Abnormality of the calcaneus (HP:0008364)2.12174100
51Short nail (HP:0001799)2.07255004
52Duplicated collecting system (HP:0000081)2.04421887
53Long clavicles (HP:0000890)2.02010651
54Small epiphyses (HP:0010585)2.01272163
55Decreased lacrimation (HP:0000633)2.01252701
56Broad distal phalanx of finger (HP:0009836)2.00140593
57Congenital stationary night blindness (HP:0007642)12.7940023
58Abnormality of chromosome segregation (HP:0002916)1.99949746
59Volvulus (HP:0002580)1.99009932
60Vertebral arch anomaly (HP:0008438)1.98463619
61Aplasia/Hypoplasia of the uvula (HP:0010293)1.97634311
62Myelodysplasia (HP:0002863)1.96512512
63Insomnia (HP:0100785)1.94567536
64Papillary thyroid carcinoma (HP:0002895)1.94372045
65Hypopigmentation of the fundus (HP:0007894)1.93342215
66Right ventricular cardiomyopathy (HP:0011663)1.93160042
67Poikilocytosis (HP:0004447)1.92363430
68* Heterotopia (HP:0002282)1.91661002
69Abnormality of the proximal phalanges of the hand (HP:0009834)1.90539030
70Soft skin (HP:0000977)1.88223097
71Protrusio acetabuli (HP:0003179)1.87609378
72Medulloblastoma (HP:0002885)1.86243997
73Cafe-au-lait spot (HP:0000957)1.85241037
74Autoamputation (HP:0001218)1.82977799
75Duplication of thumb phalanx (HP:0009942)1.82403550
76Hyperacusis (HP:0010780)1.82001786
77Milia (HP:0001056)1.80900773
78Abnormality of the carotid arteries (HP:0005344)1.80283972
79Urethral obstruction (HP:0000796)1.79433664
80Increased nuchal translucency (HP:0010880)1.79214604
81Congenital sensorineural hearing impairment (HP:0008527)1.78743658
82Abnormality of the duodenum (HP:0002246)1.78010857
83Ankle contracture (HP:0006466)1.75933962
84Wide nasal bridge (HP:0000431)1.75173611
85Embryonal neoplasm (HP:0002898)1.74866745
86Asymmetry of the thorax (HP:0001555)1.74424659
87Ependymoma (HP:0002888)1.73656251
88Abnormality of the distal phalanx of the thumb (HP:0009617)1.73132246
89Natal tooth (HP:0000695)1.72943524
90Uterine leiomyosarcoma (HP:0002891)1.72434670
91Leiomyosarcoma (HP:0100243)1.72434670
92Relative macrocephaly (HP:0004482)1.72178452
93Neonatal short-limb short stature (HP:0008921)1.71317784
94Acute myeloid leukemia (HP:0004808)1.71079806
95Optic disc pallor (HP:0000543)1.70882830
96Ectopic kidney (HP:0000086)1.69620575
97Breech presentation (HP:0001623)1.69466281
98Proximal placement of thumb (HP:0009623)1.68963295
99Facial hemangioma (HP:0000329)1.68879947
100Increased connective tissue (HP:0009025)1.67815462
101Abnormality of the heme biosynthetic pathway (HP:0010472)1.67309799
102Abnormality of the renal collecting system (HP:0004742)1.66925251
103Rhabdomyosarcoma (HP:0002859)1.65268182
104Overlapping toe (HP:0001845)1.64853853
105Deviation of the thumb (HP:0009603)1.63699146
106Abnormality of the phalanges of the hallux (HP:0010057)1.62693743
107Bowel incontinence (HP:0002607)1.61576292
108Abnormality of nail color (HP:0100643)1.61458311
109Coronal craniosynostosis (HP:0004440)1.60825321
110Sloping forehead (HP:0000340)1.60757510
111Meckel diverticulum (HP:0002245)1.59550524
112Irregular epiphyses (HP:0010582)1.59065247
113Flat capital femoral epiphysis (HP:0003370)1.58906005
114Abnormality of the epiphyses of the hand (HP:0005924)1.58694626
115Absent radius (HP:0003974)1.58675674
116Alopecia of scalp (HP:0002293)1.58524808
117Spinal cord lesions (HP:0100561)1.58243919
118Syringomyelia (HP:0003396)1.58243919
119Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.57493278
120Sparse scalp hair (HP:0002209)1.54833919
121Narrow face (HP:0000275)1.53644021
122Selective tooth agenesis (HP:0001592)1.52815646
123Flared metaphyses (HP:0003015)1.52414853
124Flattened epiphyses (HP:0003071)1.52174554
125Dysmetric saccades (HP:0000641)1.51529947
126Plantar hyperkeratosis (HP:0007556)1.51103418
127Elbow flexion contracture (HP:0002987)1.50607088
128Cupped ribs (HP:0000887)1.50401603
129Prominent nose (HP:0000448)1.50009291
130Abnormality of DNA repair (HP:0003254)1.49541653
131Obsessive-compulsive behavior (HP:0000722)1.49478345
132Abnormal large intestine physiology (HP:0012700)1.49418518
133Subcapsular cataract (HP:0000523)1.49384178
134Pili torti (HP:0003777)1.49204629
135Abnormality of the ileum (HP:0001549)1.48139334
136Freckling (HP:0001480)1.48077920
137Biliary tract neoplasm (HP:0100574)1.47978264
138High anterior hairline (HP:0009890)1.47248331
139Cholecystitis (HP:0001082)1.47136146
140Abnormal gallbladder physiology (HP:0012438)1.47136146
141Ulnar bowing (HP:0003031)1.46719725
142Aortic dissection (HP:0002647)1.46327280
143Abnormality of the astrocytes (HP:0100707)1.45825703
144Astrocytoma (HP:0009592)1.45825703
145Short 4th metacarpal (HP:0010044)1.45535305
146Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.45535305
147Large earlobe (HP:0009748)1.45253633
148Abdominal situs inversus (HP:0003363)1.44467654
149Abnormality of abdominal situs (HP:0011620)1.44467654
150Oligodactyly (HP:0012165)1.44307125
151Esophageal atresia (HP:0002032)1.43427892
152Ileus (HP:0002595)1.43209360
153Vertebral clefting (HP:0008428)1.41246510
154Acanthocytosis (HP:0001927)1.39326702
155Absent epiphyses (HP:0010577)1.38121707
156Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.38121707
157Megalencephaly (HP:0001355)1.38108131
158Delayed epiphyseal ossification (HP:0002663)1.37239287
159Aortic aneurysm (HP:0004942)1.37167141
160Shallow orbits (HP:0000586)1.36838921
161Epiphyseal dysplasia (HP:0002656)1.36623062
162Decreased electroretinogram (ERG) amplitude (HP:0000654)1.35667375
163Severe Myopia (HP:0011003)1.33974286
164Gastrointestinal carcinoma (HP:0002672)1.32015649
165Malignant gastrointestinal tract tumors (HP:0006749)1.32015649
166Fragile skin (HP:0001030)1.31993675
167Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.30721009
168Atrophic scars (HP:0001075)1.30489422
169Abnormal sex determination (HP:0012244)1.29476611
170Sex reversal (HP:0012245)1.29476611
171Blepharitis (HP:0000498)1.27366524
172Astigmatism (HP:0000483)1.27007977
173Congenital primary aphakia (HP:0007707)1.25988312
174Abnormal vertebral ossification (HP:0100569)1.25903183
175Abnormality of the 2nd finger (HP:0004100)1.25032046
176Abnormal lung lobation (HP:0002101)1.22885280
177Short 5th finger (HP:0009237)1.22156335
178Atresia of the external auditory canal (HP:0000413)1.21815007
179Short middle phalanx of the 5th finger (HP:0004220)1.21213503
180Glioma (HP:0009733)1.20075332
181Small intestinal stenosis (HP:0012848)1.20001326
182Duodenal stenosis (HP:0100867)1.20001326
183Hypoplastic pelvis (HP:0008839)1.19657556
184Onycholysis (HP:0001806)1.19299831
185Hypoplasia of the capital femoral epiphysis (HP:0003090)1.18922027
186Metaphyseal cupping (HP:0003021)1.18696076

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.91420775
2CDC73.35937441
3NEK23.25145236
4NEK12.81301614
5TTK2.72869478
6WEE12.66238738
7GRK12.62222470
8EIF2AK12.59528296
9TLK12.32860062
10BRSK12.24171653
11RPS6KA42.14923747
12BRSK22.10853338
13STK38L2.02213893
14PLK11.75073900
15AURKB1.73883407
16DDR21.71306607
17ERBB21.70787371
18MKNK11.67944394
19PKN21.61435259
20CHEK21.61316720
21EPHA31.57219714
22LATS11.46867780
23NEK91.45107273
24TESK21.44447126
25STK101.42225487
26PLK31.35219454
27AURKA1.32494611
28STK41.29988612
29MAP3K61.29836298
30ERBB41.29596795
31RPS6KB21.29537814
32MAP3K101.28389182
33EPHB21.27404314
34ACVR1B1.25613544
35NME11.25077596
36MET1.24345568
37CCNB11.24271200
38PDGFRA1.19836253
39ATR1.19674030
40STK31.18178787
41MELK1.15168089
42EIF2AK31.14909634
43SRPK11.13986991
44CDK121.11193208
45MAP3K81.08897238
46CDK81.06900267
47RPS6KA51.02148450
48BCR1.01568239
49CHEK11.01512978
50MKNK20.98703960
51KSR10.98613182
52LIMK10.96623296
53CDK70.95765020
54ICK0.95316862
55ZAK0.93295002
56CDK60.92867866
57NEK60.91305116
58PNCK0.90551479
59* PBK0.89910858
60BRAF0.89376365
61CDK40.88599425
62IRAK20.85194087
63PAK40.84933474
64LATS20.84408664
65ATM0.83650178
66PLK40.83472780
67CDK30.78700142
68FGFR10.77141919
69RAF10.75724383
70DYRK1B0.74786209
71TESK10.72680362
72KSR20.72482558
73DYRK30.71810044
74MAPK110.71298955
75NUAK10.70398791
76PAK10.68520212
77UHMK10.68518451
78WNK10.67792303
79CDK10.66927880
80PTK20.64846739
81SIK10.64474543
82RET0.63989477
83TRIB30.63741492
84FGFR20.63477057
85PAK60.63432290
86FER0.62756445
87TAF10.62700830
88FLT30.62567049
89EPHA20.61186766
90CSNK1D0.60634410
91PDK20.60453454
92PAK20.60304712
93NTRK10.59796743
94EIF2AK20.59453636
95MAP3K20.58814397
96STK390.58637681
97PTK60.58299744
98SMG10.57388469
99EEF2K0.56586434
100MAPKAPK50.55876685
101MST1R0.55732958
102CDK140.54699431
103BRD40.54183942
104CDK20.53672334
105CLK10.52419057
106MAPK100.50835286
107SCYL20.48506168
108CDK150.48423667
109EPHB10.48329324
110PRKD30.48172658
111MAPKAPK20.48147698
112ADRBK10.46791039
113CDK180.46601751
114AKT30.45787238
115RPS6KB10.44619031
116TSSK60.44295077
117MTOR0.44221772
118PDGFRB0.44112427
119MST40.43001856
120VRK10.42713560
121TGFBR10.42201694
122CDK11A0.42170955
123TTN0.40570932
124AKT20.39745589
125MAP3K110.39145739
126CAMK1D0.38496672
127YES10.37254626
128LRRK20.37015078
129PASK0.37009468
130NME20.36944815
131CDK90.35913480
132PRKDC0.35763240
133ERBB30.35725346
134MUSK0.35517634
135TRPM70.34621130
136DMPK0.33512683
137MAPK140.33138637
138MAP2K10.32412884
139BMX0.32156975
140LMTK20.31713267

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.65980479
2Cell cycle_Homo sapiens_hsa041102.47984013
3Systemic lupus erythematosus_Homo sapiens_hsa053222.28290782
4Mismatch repair_Homo sapiens_hsa034302.23733474
5Phototransduction_Homo sapiens_hsa0474411.9332958
6Spliceosome_Homo sapiens_hsa030401.93682664
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73129871
8Retinol metabolism_Homo sapiens_hsa008301.57007189
9Non-small cell lung cancer_Homo sapiens_hsa052231.54303024
10Base excision repair_Homo sapiens_hsa034101.54100243
11Nucleotide excision repair_Homo sapiens_hsa034201.50770294
12Glioma_Homo sapiens_hsa052141.47128204
13One carbon pool by folate_Homo sapiens_hsa006701.44999025
14RNA transport_Homo sapiens_hsa030131.44940264
15Thyroid cancer_Homo sapiens_hsa052161.43631664
16Alcoholism_Homo sapiens_hsa050341.39197103
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.32651295
18Endometrial cancer_Homo sapiens_hsa052131.32078377
19Fanconi anemia pathway_Homo sapiens_hsa034601.28284856
20Inositol phosphate metabolism_Homo sapiens_hsa005621.28100067
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27897841
22ECM-receptor interaction_Homo sapiens_hsa045121.27723015
23ErbB signaling pathway_Homo sapiens_hsa040121.24370235
24Homologous recombination_Homo sapiens_hsa034401.20523939
25Pentose phosphate pathway_Homo sapiens_hsa000301.19494126
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.18640210
27Thyroid hormone signaling pathway_Homo sapiens_hsa049191.18617608
28Selenocompound metabolism_Homo sapiens_hsa004501.12800248
29Steroid biosynthesis_Homo sapiens_hsa001001.08597448
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07915020
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05236398
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05047196
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.04866989
34Basal cell carcinoma_Homo sapiens_hsa052171.04439320
35Folate biosynthesis_Homo sapiens_hsa007901.03416723
36Biosynthesis of amino acids_Homo sapiens_hsa012301.03052080
37Renal cell carcinoma_Homo sapiens_hsa052111.01027946
38Non-homologous end-joining_Homo sapiens_hsa034501.00071706
39p53 signaling pathway_Homo sapiens_hsa041150.98832095
40Ribosome_Homo sapiens_hsa030100.97720983
41Viral carcinogenesis_Homo sapiens_hsa052030.97289946
42Caffeine metabolism_Homo sapiens_hsa002320.94940157
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91629271
44Proteasome_Homo sapiens_hsa030500.91319314
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91150027
46mTOR signaling pathway_Homo sapiens_hsa041500.90115406
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89105875
48Gap junction_Homo sapiens_hsa045400.88710315
49RNA degradation_Homo sapiens_hsa030180.88029754
50Hippo signaling pathway_Homo sapiens_hsa043900.87850060
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85630995
52MicroRNAs in cancer_Homo sapiens_hsa052060.84494899
53mRNA surveillance pathway_Homo sapiens_hsa030150.84305501
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83946873
55N-Glycan biosynthesis_Homo sapiens_hsa005100.82266323
56Choline metabolism in cancer_Homo sapiens_hsa052310.81137300
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.79896264
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77814050
59Vitamin B6 metabolism_Homo sapiens_hsa007500.76087980
60Oocyte meiosis_Homo sapiens_hsa041140.75208516
61Basal transcription factors_Homo sapiens_hsa030220.74974079
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74696182
63Bladder cancer_Homo sapiens_hsa052190.73262352
64Fat digestion and absorption_Homo sapiens_hsa049750.72782366
65Purine metabolism_Homo sapiens_hsa002300.71770562
66FoxO signaling pathway_Homo sapiens_hsa040680.68134982
67Estrogen signaling pathway_Homo sapiens_hsa049150.65956557
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65019008
69Circadian rhythm_Homo sapiens_hsa047100.64799989
70Pyrimidine metabolism_Homo sapiens_hsa002400.64607780
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.64564232
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.64530607
73AMPK signaling pathway_Homo sapiens_hsa041520.63937135
74Insulin signaling pathway_Homo sapiens_hsa049100.63495480
75Long-term depression_Homo sapiens_hsa047300.61755387
76Small cell lung cancer_Homo sapiens_hsa052220.60084364
77Dorso-ventral axis formation_Homo sapiens_hsa043200.59639808
78TGF-beta signaling pathway_Homo sapiens_hsa043500.59432649
79Long-term potentiation_Homo sapiens_hsa047200.59373528
80Acute myeloid leukemia_Homo sapiens_hsa052210.58568542
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58073036
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57725816
83Sulfur metabolism_Homo sapiens_hsa009200.57614966
84Fatty acid elongation_Homo sapiens_hsa000620.56658049
85Melanogenesis_Homo sapiens_hsa049160.54144943
86Tight junction_Homo sapiens_hsa045300.53764690
87HTLV-I infection_Homo sapiens_hsa051660.52264511
88Vitamin digestion and absorption_Homo sapiens_hsa049770.50535885
89Arginine and proline metabolism_Homo sapiens_hsa003300.50330498
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50015731
91Hedgehog signaling pathway_Homo sapiens_hsa043400.49739405
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49084451
93Protein digestion and absorption_Homo sapiens_hsa049740.48780726
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.47669586
95Histidine metabolism_Homo sapiens_hsa003400.47272622
96VEGF signaling pathway_Homo sapiens_hsa043700.47098821
97Notch signaling pathway_Homo sapiens_hsa043300.46880056
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46424410
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46276846
100Glutathione metabolism_Homo sapiens_hsa004800.44753742
101Colorectal cancer_Homo sapiens_hsa052100.44063050
102Glucagon signaling pathway_Homo sapiens_hsa049220.43034801
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42078492
104Lysine degradation_Homo sapiens_hsa003100.41852646
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.41807449
106ABC transporters_Homo sapiens_hsa020100.41591166
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41540712
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40957446
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40250877
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40154548
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39936544
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39754871
113Prolactin signaling pathway_Homo sapiens_hsa049170.39148679
114Chronic myeloid leukemia_Homo sapiens_hsa052200.37831778
115Fructose and mannose metabolism_Homo sapiens_hsa000510.37338165
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.36896937
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36852822
118Proteoglycans in cancer_Homo sapiens_hsa052050.36227510
119Herpes simplex infection_Homo sapiens_hsa051680.34925921
120Malaria_Homo sapiens_hsa051440.34878266
121Pancreatic cancer_Homo sapiens_hsa052120.34507218
122Mineral absorption_Homo sapiens_hsa049780.34189075
123RNA polymerase_Homo sapiens_hsa030200.30785819
124Epstein-Barr virus infection_Homo sapiens_hsa051690.30684623
125Linoleic acid metabolism_Homo sapiens_hsa005910.29566196
126Carbon metabolism_Homo sapiens_hsa012000.29174739
127Pyruvate metabolism_Homo sapiens_hsa006200.28795084
128Adherens junction_Homo sapiens_hsa045200.26279628
129Hepatitis B_Homo sapiens_hsa051610.25520724
130Pathways in cancer_Homo sapiens_hsa052000.25055058
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24623542
132Focal adhesion_Homo sapiens_hsa045100.24471832
133Primary bile acid biosynthesis_Homo sapiens_hsa001200.24343299
134Chemical carcinogenesis_Homo sapiens_hsa052040.23449190
135Ether lipid metabolism_Homo sapiens_hsa005650.22702542
136Arginine biosynthesis_Homo sapiens_hsa002200.22021915
137Wnt signaling pathway_Homo sapiens_hsa043100.21302088
138Prostate cancer_Homo sapiens_hsa052150.20778381
139Melanoma_Homo sapiens_hsa052180.18722727
140Sphingolipid metabolism_Homo sapiens_hsa006000.18275846
141Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.17729382
142Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.17347000

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