GPRIN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1dendritic spine morphogenesis (GO:0060997)7.01038496
2pyrimidine nucleobase catabolic process (GO:0006208)6.60830711
3desmosome organization (GO:0002934)5.97174106
4nucleobase catabolic process (GO:0046113)5.21544183
5layer formation in cerebral cortex (GO:0021819)5.17980002
6locomotory exploration behavior (GO:0035641)5.10198326
7negative regulation of microtubule polymerization (GO:0031115)4.95942480
8cell migration in hindbrain (GO:0021535)4.93163998
9bundle of His cell to Purkinje myocyte communication (GO:0086069)4.91755289
10axonal fasciculation (GO:0007413)4.81270298
11negative regulation of catenin import into nucleus (GO:0035414)4.68118502
12regulation of short-term neuronal synaptic plasticity (GO:0048172)4.55772209
13establishment of skin barrier (GO:0061436)4.55460665
14neuron recognition (GO:0008038)4.48974989
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.44560364
16regulation of water loss via skin (GO:0033561)4.44294981
17vocalization behavior (GO:0071625)4.34864709
18synaptic vesicle maturation (GO:0016188)4.27835906
19central nervous system projection neuron axonogenesis (GO:0021952)4.26194387
20response to pheromone (GO:0019236)4.14454834
21neuron cell-cell adhesion (GO:0007158)4.13437599
22establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)4.12740327
23lipopolysaccharide biosynthetic process (GO:0009103)4.12512427
24multicellular organismal water homeostasis (GO:0050891)4.10480978
25synaptic vesicle docking involved in exocytosis (GO:0016081)4.08994216
26positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.08213508
27postsynaptic membrane organization (GO:0001941)4.04449959
28epithelial cell-cell adhesion (GO:0090136)4.02576665
29dendritic spine organization (GO:0097061)3.99911302
30protein localization to synapse (GO:0035418)3.95459763
31dendrite morphogenesis (GO:0048813)3.91202434
32regulation of bile acid biosynthetic process (GO:0070857)3.89960968
33regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.87735800
34calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.84783058
35exploration behavior (GO:0035640)3.82286343
36regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.80561419
37surfactant homeostasis (GO:0043129)3.80276552
38proline transport (GO:0015824)3.78668316
39regulation of glutamate receptor signaling pathway (GO:1900449)3.73070573
40cerebellar granule cell differentiation (GO:0021707)3.72324613
41positive regulation of synaptic transmission, GABAergic (GO:0032230)3.64621891
42neuronal stem cell maintenance (GO:0097150)3.63552010
43chemical homeostasis within a tissue (GO:0048875)3.62206883
44renal system process involved in regulation of blood volume (GO:0001977)3.58881780
45regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.51390170
46lipopolysaccharide metabolic process (GO:0008653)3.48651069
47establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.47573774
48mitochondrion transport along microtubule (GO:0047497)3.47573774
49positive regulation of axon extension (GO:0045773)3.44899172
50establishment of mitochondrion localization (GO:0051654)3.43543395
51regulation of glycogen (starch) synthase activity (GO:2000465)3.39905827
52embryonic retina morphogenesis in camera-type eye (GO:0060059)3.38468638
53water homeostasis (GO:0030104)3.37188118
54axon extension (GO:0048675)3.37131194
55polarized epithelial cell differentiation (GO:0030859)3.36630231
56gap junction assembly (GO:0016264)3.35924974
57negative regulation of cell fate specification (GO:0009996)3.33339064
58positive regulation of synapse assembly (GO:0051965)3.30954484
59homocysteine metabolic process (GO:0050667)3.30543921
60apical protein localization (GO:0045176)3.27626549
61keratinization (GO:0031424)3.27464264
62establishment or maintenance of bipolar cell polarity (GO:0061245)3.27077376
63establishment or maintenance of apical/basal cell polarity (GO:0035088)3.27077376
64daunorubicin metabolic process (GO:0044597)3.26950595
65polyketide metabolic process (GO:0030638)3.26950595
66doxorubicin metabolic process (GO:0044598)3.26950595
67auditory receptor cell differentiation (GO:0042491)3.26926291
68NADH metabolic process (GO:0006734)3.26331748
69positive regulation of synapse maturation (GO:0090129)3.25401404
70angiotensin maturation (GO:0002003)3.23987529
71cell-cell junction maintenance (GO:0045217)3.23329276
72planar cell polarity pathway involved in neural tube closure (GO:0090179)3.22998946
73regulation of cAMP-dependent protein kinase activity (GO:2000479)3.21738520
74protein retention in ER lumen (GO:0006621)3.18760129
75cerebellar Purkinje cell differentiation (GO:0021702)3.16227086
76glutamate secretion (GO:0014047)3.15617461
77regulation of synaptic vesicle exocytosis (GO:2000300)3.15179568
78adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.14731999
79negative regulation of cell fate commitment (GO:0010454)3.14353759
80establishment of apical/basal cell polarity (GO:0035089)3.14290722
81detection of temperature stimulus involved in sensory perception (GO:0050961)3.13764399
82detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.13764399
83regulation of synapse structural plasticity (GO:0051823)3.13089978
84prostaglandin metabolic process (GO:0006693)3.12865664
85prostanoid metabolic process (GO:0006692)3.12865664
86synaptic vesicle exocytosis (GO:0016079)3.12191038
87pre-miRNA processing (GO:0031054)3.11194992
88protein autoprocessing (GO:0016540)3.11102652
89phospholipid efflux (GO:0033700)3.10856781
90peptidyl-tyrosine autophosphorylation (GO:0038083)3.10288858
91regulation of posttranscriptional gene silencing (GO:0060147)3.10151576
92regulation of gene silencing by miRNA (GO:0060964)3.10151576
93regulation of gene silencing by RNA (GO:0060966)3.10151576
94regulation of microtubule polymerization (GO:0031113)3.09894322
95neurotransmitter secretion (GO:0007269)3.07509721
96central nervous system neuron axonogenesis (GO:0021955)3.04976775
97detection of temperature stimulus (GO:0016048)3.04824280
98positive regulation of dendrite morphogenesis (GO:0050775)3.03307373
99positive regulation of dendritic spine morphogenesis (GO:0061003)3.03014241
100cellular response to nitric oxide (GO:0071732)3.02128452
101regulation of cell fate specification (GO:0042659)3.01894891
102biotin metabolic process (GO:0006768)3.01780567
103branching involved in labyrinthine layer morphogenesis (GO:0060670)3.01349234
104cell differentiation in hindbrain (GO:0021533)3.00919102
105cellular response to vitamin D (GO:0071305)3.00359649
106positive regulation of dendritic spine development (GO:0060999)3.00333848
107regulation of axon extension (GO:0030516)2.99912660
108regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.99521437
109regulation of cholesterol homeostasis (GO:2000188)2.98821175
110head development (GO:0060322)2.97891063
111regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.97687793
112regulation of guanylate cyclase activity (GO:0031282)2.96082146
113paraxial mesoderm development (GO:0048339)2.95335657
114negative regulation of keratinocyte proliferation (GO:0010839)2.95175689
115dopamine receptor signaling pathway (GO:0007212)2.95135122
116organelle transport along microtubule (GO:0072384)2.94313767
117intestinal absorption (GO:0050892)2.93377360
118lipoprotein transport (GO:0042953)2.93261317
119response to histamine (GO:0034776)2.93225897
120primary alcohol catabolic process (GO:0034310)2.93090735
121maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.92221125
122hemidesmosome assembly (GO:0031581)2.91259567
123establishment or maintenance of monopolar cell polarity (GO:0061339)2.90210968
124establishment of monopolar cell polarity (GO:0061162)2.90210968
125regulation of hippo signaling (GO:0035330)2.89918154
126regulation of systemic arterial blood pressure by hormone (GO:0001990)2.89348035
127regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.89348035
128endocrine process (GO:0050886)2.89348035
129prostanoid biosynthetic process (GO:0046457)2.87650760
130prostaglandin biosynthetic process (GO:0001516)2.87650760
131glutamate receptor signaling pathway (GO:0007215)2.86224151
132neuron projection extension (GO:1990138)2.85650468
133aminoglycoside antibiotic metabolic process (GO:0030647)2.84952247
134positive regulation of dendrite development (GO:1900006)2.84896211
135branching involved in prostate gland morphogenesis (GO:0060442)2.81805550
136positive regulation of pseudopodium assembly (GO:0031274)2.81481772
137epithelial cell differentiation involved in kidney development (GO:0035850)2.81404494
138ionotropic glutamate receptor signaling pathway (GO:0035235)2.81281638
139lung-associated mesenchyme development (GO:0060484)2.80612504
140asymmetric protein localization (GO:0008105)2.79389863
141axon cargo transport (GO:0008088)2.79147964
142regulation of NFAT protein import into nucleus (GO:0051532)2.77233736
143retinal ganglion cell axon guidance (GO:0031290)2.76996801
144regulation of synapse assembly (GO:0051963)2.76030846
145regulation of extent of cell growth (GO:0061387)2.75843536
146negative regulation of organelle assembly (GO:1902116)2.75810835
147regulation of systemic arterial blood pressure (GO:0003073)2.75477701
148long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.73902326
149tight junction assembly (GO:0070830)2.72961012
150mating behavior (GO:0007617)2.72937129
151toxin transport (GO:1901998)2.72775851
152branching involved in salivary gland morphogenesis (GO:0060445)2.72312848
153intestinal epithelial cell development (GO:0060576)2.71905248
154positive regulation of axonogenesis (GO:0050772)2.71749552
155innervation (GO:0060384)2.71639034
156vesicle transport along microtubule (GO:0047496)2.71295788
157fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.69502515
158behavioral response to ethanol (GO:0048149)2.69486269
1594-hydroxyproline metabolic process (GO:0019471)2.69380372
160regulation of neuronal synaptic plasticity (GO:0048168)2.69200914
161renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.69066723
162regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.68325891
163cell junction maintenance (GO:0034331)2.68123406
164artery development (GO:0060840)2.67994835
165semaphorin-plexin signaling pathway (GO:0071526)2.67544064
166very-low-density lipoprotein particle assembly (GO:0034379)2.67029678
167plasma lipoprotein particle assembly (GO:0034377)2.65829030
168cerebral cortex radially oriented cell migration (GO:0021799)2.65781415
169negative regulation of astrocyte differentiation (GO:0048712)2.65465032
170regulation of cardioblast differentiation (GO:0051890)2.65332275
171positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.64073287
172neuron migration (GO:0001764)2.63619095
173auditory behavior (GO:0031223)2.63130358
174clathrin coat assembly (GO:0048268)2.63076491
175negative regulation of microtubule polymerization or depolymerization (GO:0031111)2.61804016
176regulation of synapse organization (GO:0050807)2.61703001
177long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.60690777
178regulation of synaptic vesicle transport (GO:1902803)2.60483130
179hair cell differentiation (GO:0035315)2.59323849
180prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.59123169
181gamma-aminobutyric acid transport (GO:0015812)2.58672834
182cytoskeletal anchoring at plasma membrane (GO:0007016)2.57926587
183regulation of axonogenesis (GO:0050770)2.57899706
184phosphate ion transmembrane transport (GO:0035435)2.57580369
185hormone catabolic process (GO:0042447)2.57522930
186regulation of long-term neuronal synaptic plasticity (GO:0048169)2.56545671
187regulation of dendrite morphogenesis (GO:0048814)2.55403410
188cerebellum development (GO:0021549)2.55376831
189establishment of nucleus localization (GO:0040023)2.55189235
190sulfate transmembrane transport (GO:1902358)2.52718149
191sodium ion homeostasis (GO:0055078)2.51097100
192receptor recycling (GO:0001881)2.50672450
193sphingomyelin metabolic process (GO:0006684)2.50543234
194cell-cell junction assembly (GO:0007043)2.47014392
195fatty-acyl-CoA biosynthetic process (GO:0046949)2.45812695
196epithelial cell differentiation involved in prostate gland development (GO:0060742)2.45218454

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.66693728
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.44821862
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.78550971
4CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.20310827
5EZH2_27304074_Chip-Seq_ESCs_Mouse3.15871269
6CDX2_20551321_ChIP-Seq_CACO-2_Human3.05995691
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98507167
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.97652817
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.90506497
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.86943993
11EZH2_27294783_Chip-Seq_ESCs_Mouse2.78903477
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70608840
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70608840
14SUZ12_27294783_Chip-Seq_ESCs_Mouse2.66736716
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.62426116
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.61936998
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.61671586
18* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.56045719
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55617622
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55176972
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45302696
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42687981
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42285380
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.32956938
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.26555554
26REST_21632747_ChIP-Seq_MESCs_Mouse2.20225588
27DROSHA_22980978_ChIP-Seq_HELA_Human2.18409229
28SOX2_27498859_Chip-Seq_STOMACH_Mouse2.18105789
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.17602121
30GBX2_23144817_ChIP-Seq_PC3_Human2.16598729
31AR_21909140_ChIP-Seq_LNCAP_Human2.12773203
32RACK7_27058665_Chip-Seq_MCF-7_Human2.12261753
33RARG_19884340_ChIP-ChIP_MEFs_Mouse2.05790300
34BMI1_23680149_ChIP-Seq_NPCS_Mouse2.04333752
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.02359748
36CLOCK_20551151_ChIP-Seq_293T_Human1.92641848
37RING1B_27294783_Chip-Seq_ESCs_Mouse1.86131773
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85114893
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.84059639
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.80805646
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.80505063
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.78641836
43* GATA6_25053715_ChIP-Seq_YYC3_Human1.77922978
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.77224392
45ZNF274_21170338_ChIP-Seq_K562_Hela1.74676650
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71972728
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71924267
48NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.69902326
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.68173034
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.67683903
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.67608949
52AR_21572438_ChIP-Seq_LNCaP_Human1.67326019
53NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.67015565
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.65845179
55SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.63558493
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.63244991
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.62773803
58IGF1R_20145208_ChIP-Seq_DFB_Human1.61072664
59* GATA4_25053715_ChIP-Seq_YYC3_Human1.59421795
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59212887
61TCF3_18692474_ChIP-Seq_MEFs_Mouse1.57967522
62* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.57764219
63RING1B_27294783_Chip-Seq_NPCs_Mouse1.57455426
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56766053
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.54476418
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52793862
67SOX2_20726797_ChIP-Seq_SW620_Human1.50562778
68OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.49120682
69KDM2B_26808549_Chip-Seq_K562_Human1.48457459
70TRIM28_21343339_ChIP-Seq_HEK293_Human1.47796978
71CREB1_26743006_Chip-Seq_LNCaP_Human1.43797337
72FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.42690570
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41723766
74SOX9_24532713_ChIP-Seq_HFSC_Mouse1.41087460
75DNAJC2_21179169_ChIP-ChIP_NT2_Human1.40704684
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39400778
77TP53_20018659_ChIP-ChIP_R1E_Mouse1.39228782
78ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.38160754
79* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.37468389
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37162461
81RUNX1_27514584_Chip-Seq_MCF-7_Human1.36168803
82P63_26484246_Chip-Seq_KERATINOCYTES_Human1.35760027
83ZNF263_19887448_ChIP-Seq_K562_Human1.34932164
84RARB_27405468_Chip-Seq_BRAIN_Mouse1.34321433
85FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.33450690
86EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32473571
87RNF2_27304074_Chip-Seq_NSC_Mouse1.31166226
88TET1_21451524_ChIP-Seq_MESCs_Mouse1.29182045
89* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28841521
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27858474
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27858474
92KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.26358038
93KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.26358038
94KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.26358038
95KLF5_25053715_ChIP-Seq_YYC3_Human1.25384652
96ZFP281_27345836_Chip-Seq_ESCs_Mouse1.25265798
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24882902
98* CTCF_27219007_Chip-Seq_Bcells_Human1.24566895
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23780615
100NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.23626025
101ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23577331
102ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21985642
103WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21905643
104KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21165699
105SOX2_21211035_ChIP-Seq_LN229_Gbm1.20828968
106RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20605700
107SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20397973
108GATA1_26923725_Chip-Seq_HPCs_Mouse1.19389111
109SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17607396
110TCF3_18692474_ChIP-Seq_MESCs_Mouse1.17518372
111SMAD3_21741376_ChIP-Seq_ESCs_Human1.17291689
112SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17059818
113* CHD1_26751641_Chip-Seq_LNCaP_Human1.16856871
114SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16712859
115SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16271377
116TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16036487
117ISL1_27105846_Chip-Seq_CPCs_Mouse1.16013975
118* FOXA1_25552417_ChIP-Seq_VCAP_Human1.15844223
119SMC4_20622854_ChIP-Seq_HELA_Human1.14167554
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12682197
121ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11470232
122* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10789960
123* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10658227
124ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10627291
125OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10492744
126TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09593054
127SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08077979
128PPARA_22158963_ChIP-Seq_LIVER_Mouse1.08003724
129YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07504526
130TP63_22573176_ChIP-Seq_HFKS_Human1.07419747
131TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06795619
132NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05683054
133* LXR_22292898_ChIP-Seq_THP-1_Human1.05309258
134P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05204565
135ATF3_27146783_Chip-Seq_COLON_Human1.04885965
136TET1_21490601_ChIP-Seq_MESCs_Mouse1.04837986
137RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04521908
138MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04415222
139WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04402443
140NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.03799094
141JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.03650580
142P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03324286
143AHR_22903824_ChIP-Seq_MCF-7_Human1.02954681
144CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02827584
145RXR_22158963_ChIP-Seq_LIVER_Mouse1.02182946
146SMAD4_21741376_ChIP-Seq_HESCs_Human1.02032491
147ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01471475
148FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01368494
149SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01206697
150SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00975045
151AR_19668381_ChIP-Seq_PC3_Human0.98576519
152SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98538462
153P300_19829295_ChIP-Seq_ESCs_Human0.97875551
154BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.97720538
155* SMAD4_21799915_ChIP-Seq_A2780_Human0.97517723
156NANOG_21062744_ChIP-ChIP_HESCs_Human0.97352678
157TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97250409
158ELK3_25401928_ChIP-Seq_HUVEC_Human0.97051271
159SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96218399
160ARNT_22903824_ChIP-Seq_MCF-7_Human0.95329165
161CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92860947
162RUNX2_22187159_ChIP-Seq_PCA_Human0.92160103
163SMAD3_21741376_ChIP-Seq_EPCs_Human0.90771629
164ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87223630
165OCT4_19829295_ChIP-Seq_ESCs_Human0.86767756
166MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.86576459
167* PIAS1_25552417_ChIP-Seq_VCAP_Human0.84171339
168TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84053188
169STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.83970738
170NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83480897
171NR3C1_23031785_ChIP-Seq_PC12_Mouse0.82436135
172ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.81995566
173DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.81238094
174* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80704295
175DPY_21335234_ChIP-Seq_ESCs_Mouse0.78797220
176ESR1_15608294_ChIP-ChIP_MCF-7_Human0.77565041
177RBPJ_22232070_ChIP-Seq_NCS_Mouse0.77478664
178TCF4_18268006_ChIP-ChIP_LS174T_Human0.76939488
179HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.75949237

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.68450916
2MP0002796_impaired_skin_barrier3.62481989
3MP0003880_abnormal_central_pattern3.62312910
4MP0004270_analgesia3.48684165
5MP0005423_abnormal_somatic_nervous3.12553699
6MP0004264_abnormal_extraembryonic_tissu3.01347680
7MP0003635_abnormal_synaptic_transmissio2.96638581
8MP0010368_abnormal_lymphatic_system2.93303727
9MP0002102_abnormal_ear_morphology2.92060975
10MP0004782_abnormal_surfactant_physiolog2.90620933
11MP0000778_abnormal_nervous_system2.86846096
12MP0002254_reproductive_system_inflammat2.85356331
13MP0000566_synostosis2.78502186
14MP0005360_urolithiasis2.74318377
15MP0001968_abnormal_touch/_nociception2.67366392
16MP0002735_abnormal_chemical_nociception2.59542349
17MP0002733_abnormal_thermal_nociception2.58741837
18MP0003122_maternal_imprinting2.58341049
19MP0004858_abnormal_nervous_system2.42527633
20MP0002734_abnormal_mechanical_nocicepti2.41620887
21MP0003941_abnormal_skin_development2.38432692
22MP0005409_darkened_coat_color2.34059920
23MP0000579_abnormal_nail_morphology2.29738133
24MP0002184_abnormal_innervation2.26661030
25MP0005501_abnormal_skin_physiology2.25477899
26MP0002063_abnormal_learning/memory/cond2.19479784
27MP0009745_abnormal_behavioral_response2.17982541
28MP0009840_abnormal_foam_cell2.16763289
29MP0006276_abnormal_autonomic_nervous2.00134176
30MP0010352_gastrointestinal_tract_polyps1.97905665
31MP0001188_hyperpigmentation1.94160109
32MP0003315_abnormal_perineum_morphology1.92684955
33MP0009046_muscle_twitch1.91534776
34MP0005623_abnormal_meninges_morphology1.90859812
35MP0002822_catalepsy1.90029605
36MP0005187_abnormal_penis_morphology1.88646707
37MP0000955_abnormal_spinal_cord1.84468202
38MP0004185_abnormal_adipocyte_glucose1.83582639
39MP0002139_abnormal_hepatobiliary_system1.82770946
40MP0001666_abnormal_nutrient_absorption1.82755056
41MP0002751_abnormal_autonomic_nervous1.82713523
42MP0009780_abnormal_chondrocyte_physiolo1.77599693
43MP0010030_abnormal_orbit_morphology1.77534652
44MP0004019_abnormal_vitamin_homeostasis1.77082957
45MP0004811_abnormal_neuron_physiology1.76957103
46MP0000569_abnormal_digit_pigmentation1.75804603
47MP0002572_abnormal_emotion/affect_behav1.73565927
48MP0002736_abnormal_nociception_after1.72815145
49MP0000462_abnormal_digestive_system1.71744847
50MP0002909_abnormal_adrenal_gland1.71097279
51MP0002064_seizures1.69871199
52MP0009379_abnormal_foot_pigmentation1.69777078
53MP0001970_abnormal_pain_threshold1.67767695
54MP0005085_abnormal_gallbladder_physiolo1.61939394
55MP0001486_abnormal_startle_reflex1.55561869
56MP0006072_abnormal_retinal_apoptosis1.54220940
57MP0002557_abnormal_social/conspecific_i1.48264607
58MP0003329_amyloid_beta_deposits1.45614674
59MP0003453_abnormal_keratinocyte_physiol1.45481622
60MP0004885_abnormal_endolymph1.44583854
61MP0002067_abnormal_sensory_capabilities1.44028574
62MP0002882_abnormal_neuron_morphology1.43429249
63MP0001529_abnormal_vocalization1.40898582
64MP0003890_abnormal_embryonic-extraembry1.39721684
65MP0001440_abnormal_grooming_behavior1.39560876
66MP0004272_abnormal_basement_membrane1.39265573
67MP0003878_abnormal_ear_physiology1.38184800
68MP0005377_hearing/vestibular/ear_phenot1.38184800
69MP0003121_genomic_imprinting1.35084103
70MP0003566_abnormal_cell_adhesion1.33723948
71MP0002272_abnormal_nervous_system1.33470988
72MP0002098_abnormal_vibrissa_morphology1.31882361
73MP0003861_abnormal_nervous_system1.30430648
74MP0000538_abnormal_urinary_bladder1.29355418
75MP0008961_abnormal_basal_metabolism1.29212425
76MP0000631_abnormal_neuroendocrine_gland1.28499673
77MP0005666_abnormal_adipose_tissue1.28212928
78MP0002653_abnormal_ependyma_morphology1.26844675
79MP0000537_abnormal_urethra_morphology1.26623775
80MP0002152_abnormal_brain_morphology1.23205347
81MP0000647_abnormal_sebaceous_gland1.22674138
82MP0004924_abnormal_behavior1.21897104
83MP0005386_behavior/neurological_phenoty1.21897104
84MP0004133_heterotaxia1.21398212
85MP0000377_abnormal_hair_follicle1.20550822
86MP0001216_abnormal_epidermal_layer1.20541575
87MP0001299_abnormal_eye_distance/1.20262370
88MP0000383_abnormal_hair_follicle1.19478989
89MP0000477_abnormal_intestine_morphology1.19305184
90MP0003705_abnormal_hypodermis_morpholog1.16404282
91MP0005670_abnormal_white_adipose1.14781950
92MP0001661_extended_life_span1.14228417
93MP0005365_abnormal_bile_salt1.13873578
94MP0001849_ear_inflammation1.12142036
95MP0002066_abnormal_motor_capabilities/c1.10982591
96MP0003137_abnormal_impulse_conducting1.10261429
97MP0000678_abnormal_parathyroid_gland1.09362120
98MP0002009_preneoplasia1.08596136
99MP0010771_integument_phenotype1.08125382
100MP0005248_abnormal_Harderian_gland1.07316430
101MP0002234_abnormal_pharynx_morphology1.06167121
102MP0010678_abnormal_skin_adnexa1.05559209
103MP0005275_abnormal_skin_tensile1.04052839
104MP0003119_abnormal_digestive_system1.02493793
105MP0002752_abnormal_somatic_nervous1.01486103
106MP0001664_abnormal_digestion1.00805876
107MP0003283_abnormal_digestive_organ0.99661421
108MP0003183_abnormal_peptide_metabolism0.99607707
109MP0009672_abnormal_birth_weight0.98909048
110MP0000762_abnormal_tongue_morphology0.98470537
111MP0004130_abnormal_muscle_cell0.97578859
112MP0003787_abnormal_imprinting0.97174608
113MP0003385_abnormal_body_wall0.97020624
114MP0005257_abnormal_intraocular_pressure0.95196349
115MP0002111_abnormal_tail_morphology0.93576680
116MP0005451_abnormal_body_composition0.91712158
117MP0002069_abnormal_eating/drinking_beha0.91467013
118MP0003937_abnormal_limbs/digits/tail_de0.90103952
119MP0005076_abnormal_cell_differentiation0.89862548
120MP0001730_embryonic_growth_arrest0.88153511
121MP0001485_abnormal_pinna_reflex0.87535405
122MP0001501_abnormal_sleep_pattern0.87401424
123MP0000534_abnormal_ureter_morphology0.86298809
124MP0002081_perinatal_lethality0.85488086
125MP0008569_lethality_at_weaning0.83851585
126MP0002095_abnormal_skin_pigmentation0.83047688
127MP0003123_paternal_imprinting0.81794104
128MP0001986_abnormal_taste_sensitivity0.80865185
129MP0003959_abnormal_lean_body0.80728423
130MP0005645_abnormal_hypothalamus_physiol0.80452107
131MP0005503_abnormal_tendon_morphology0.80079635
132MP0001270_distended_abdomen0.79693873
133MP0004742_abnormal_vestibular_system0.78985501
134MP0000427_abnormal_hair_cycle0.78647543
135MP0001943_abnormal_respiration0.78071892
136MP0009643_abnormal_urine_homeostasis0.77868474
137MP0008995_early_reproductive_senescence0.75500274
138MP0001348_abnormal_lacrimal_gland0.75463883
139MP0002089_abnormal_postnatal_growth/wei0.75414679
140MP0000490_abnormal_crypts_of0.74704967
141MP0002876_abnormal_thyroid_physiology0.74108498
142MP0003879_abnormal_hair_cell0.74050305
143MP0000049_abnormal_middle_ear0.73104352
144MP0003172_abnormal_lysosome_physiology0.71651850
145MP0001879_abnormal_lymphatic_vessel0.71188038
146MP0002697_abnormal_eye_size0.71062302
147MP0002084_abnormal_developmental_patter0.70542119
148MP0000467_abnormal_esophagus_morphology0.69082446
149MP0002166_altered_tumor_susceptibility0.68621645
150MP0010234_abnormal_vibrissa_follicle0.67928200
151MP0002006_tumorigenesis0.66210132
152MP0002932_abnormal_joint_morphology0.65673097
153MP0001286_abnormal_eye_development0.65403814
154MP0008770_decreased_survivor_rate0.64948955
155MP0002837_dystrophic_cardiac_calcinosis0.64367767
156MP0001765_abnormal_ion_homeostasis0.64342729
157MP0002282_abnormal_trachea_morphology0.64309011
158MP0000516_abnormal_urinary_system0.63953554
159MP0005367_renal/urinary_system_phenotyp0.63953554
160MP0005332_abnormal_amino_acid0.63475870
161MP0002233_abnormal_nose_morphology0.62864095
162MP0001756_abnormal_urination0.62688747
163MP0006138_congestive_heart_failure0.62039839
164MP0000751_myopathy0.61957053
165MP0002092_abnormal_eye_morphology0.61550848
166MP0001293_anophthalmia0.61216191
167MP0003011_delayed_dark_adaptation0.60627373
168MP0005535_abnormal_body_temperature0.60432035
169MP0000432_abnormal_head_morphology0.59517082
170MP0001873_stomach_inflammation0.59398494
171MP0005381_digestive/alimentary_phenotyp0.59235661
172MP0003718_maternal_effect0.58404820
173MP0002085_abnormal_embryonic_tissue0.58107725
174MP0002060_abnormal_skin_morphology0.56415973
175MP0004233_abnormal_muscle_weight0.56344807

Predicted human phenotypes

RankGene SetZ-score
1Bilateral sensorineural hearing impairment (HP:0008619)4.36831448
2Right ventricular cardiomyopathy (HP:0011663)4.21401902
3Duplicated collecting system (HP:0000081)3.96446645
4Partial duplication of thumb phalanx (HP:0009944)3.86248262
5Abnormality of the distal phalanx of the thumb (HP:0009617)3.65210552
6Malnutrition (HP:0004395)3.59049175
7Ankle clonus (HP:0011448)3.52560034
8Flat acetabular roof (HP:0003180)3.51771697
9Hyperactive renin-angiotensin system (HP:0000841)3.50955350
10Renal duplication (HP:0000075)3.50143289
11Excessive salivation (HP:0003781)3.44165456
12Drooling (HP:0002307)3.44165456
13Hyperacusis (HP:0010780)3.32227235
14Mutism (HP:0002300)3.31540315
15Abnormality of dentin (HP:0010299)3.29700758
16Myokymia (HP:0002411)3.26613771
17Abnormality of glutamine family amino acid metabolism (HP:0010902)3.21073642
18Abnormality of the renal collecting system (HP:0004742)3.20204844
19Elfin facies (HP:0004428)3.19215883
20Severe visual impairment (HP:0001141)3.11568913
21Partial duplication of the phalanx of hand (HP:0009999)3.09069613
22Progressive inability to walk (HP:0002505)3.01426486
23Insomnia (HP:0100785)3.00630088
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.96056713
25Broad-based gait (HP:0002136)2.92959895
26Interstitial pulmonary disease (HP:0006530)2.91994788
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.91902935
28Aplasia involving bones of the upper limbs (HP:0009823)2.89684531
29Aplasia of the phalanges of the hand (HP:0009802)2.89684531
30Aplasia involving bones of the extremities (HP:0009825)2.89684531
31Overriding aorta (HP:0002623)2.86071869
32Renovascular hypertension (HP:0100817)2.85979285
33Abnormal pancreas size (HP:0012094)2.84279480
34Amyotrophic lateral sclerosis (HP:0007354)2.83801035
35Cortical dysplasia (HP:0002539)2.68943464
36Supranuclear gaze palsy (HP:0000605)2.68051131
37Flat cornea (HP:0007720)2.61362525
38Akinesia (HP:0002304)2.59498976
39Concave nail (HP:0001598)2.57793216
40Focal seizures (HP:0007359)2.57165883
41Annular pancreas (HP:0001734)2.56068393
42Decreased circulating renin level (HP:0003351)2.49008333
43Hyperventilation (HP:0002883)2.47962508
44Poor eye contact (HP:0000817)2.47355888
45Choanal stenosis (HP:0000452)2.47209116
46Aplasia of the musculature (HP:0100854)2.45322920
47Tinnitus (HP:0000360)2.45061571
48Abnormality of the corticospinal tract (HP:0002492)2.42169674
49Limb dystonia (HP:0002451)2.42137511
50Abnormality of permanent molar morphology (HP:0011071)2.41611260
51Abnormality of the dental root (HP:0006486)2.41611260
52Taurodontia (HP:0000679)2.41611260
53Lower limb amyotrophy (HP:0007210)2.41234252
54Broad metatarsal (HP:0001783)2.38904216
55Shallow orbits (HP:0000586)2.38728580
56Hypsarrhythmia (HP:0002521)2.38477659
57Inability to walk (HP:0002540)2.38311815
58Visual hallucinations (HP:0002367)2.37745341
59Hypoplasia of the brainstem (HP:0002365)2.37440377
60Aplasia/Hypoplasia of the brainstem (HP:0007362)2.37440377
61Exotropia (HP:0000577)2.37293276
62Flattened epiphyses (HP:0003071)2.37086965
63Mixed hearing impairment (HP:0000410)2.35348548
64Epileptic encephalopathy (HP:0200134)2.34072907
65Abnormal hair laboratory examination (HP:0003328)2.33651960
66Hepatoblastoma (HP:0002884)2.32535106
67Pointed chin (HP:0000307)2.32366962
68Short nail (HP:0001799)2.31598392
69EEG with generalized epileptiform discharges (HP:0011198)2.30808331
70Urinary urgency (HP:0000012)2.30529799
71Reticulocytopenia (HP:0001896)2.29687086
72Focal motor seizures (HP:0011153)2.28306555
73Palmoplantar hyperkeratosis (HP:0000972)2.26821807
74Hyperglycinuria (HP:0003108)2.24641141
75Lissencephaly (HP:0001339)2.22398087
76Palmar hyperkeratosis (HP:0010765)2.22140802
77Abnormality of salivation (HP:0100755)2.22104852
78Termporal pattern (HP:0011008)2.20872032
79Insidious onset (HP:0003587)2.20872032
80Epileptiform EEG discharges (HP:0011182)2.18333845
81Abnormality of the salivary glands (HP:0010286)2.18172832
82Hypoplastic nipples (HP:0002557)2.17850471
83Abnormality of molar (HP:0011077)2.17704591
84Abnormality of molar morphology (HP:0011070)2.17704591
85Growth hormone excess (HP:0000845)2.16327976
86High anterior hairline (HP:0009890)2.15762585
87Absent eyelashes (HP:0000561)2.15606745
88Hypotrichosis (HP:0001006)2.14500206
89Agitation (HP:0000713)2.14294603
90Chromsome breakage (HP:0040012)2.13833505
91Short humerus (HP:0005792)2.13242956
92Inappropriate behavior (HP:0000719)2.13015622
93Amblyopia (HP:0000646)2.11858732
94Impaired social interactions (HP:0000735)2.11839993
95Abnormal social behavior (HP:0012433)2.11839993
96Morphological abnormality of the pyramidal tract (HP:0002062)2.09546057
97Abnormality of the dental pulp (HP:0006479)2.09427905
98Protruding tongue (HP:0010808)2.09221537
99Papilledema (HP:0001085)2.09199197
100Aplastic anemia (HP:0001915)2.08927328
101Vertebral clefting (HP:0008428)2.08236651
102Abnormality of the 1st metacarpal (HP:0010009)2.07660218
103Congenital ichthyosiform erythroderma (HP:0007431)2.07214251
104Focal segmental glomerulosclerosis (HP:0000097)2.07159207
105Abnormal tarsal ossification (HP:0008369)2.06633071
106Plantar hyperkeratosis (HP:0007556)2.05579730
107Germ cell neoplasia (HP:0100728)2.05481973
108Advanced eruption of teeth (HP:0006288)2.05427478
109Abnormality of carpal bone ossification (HP:0006257)2.03894670
110Turricephaly (HP:0000262)2.03279590
111Impaired pain sensation (HP:0007328)2.02413133
112Abnormality of pain sensation (HP:0010832)2.02413133
113Torticollis (HP:0000473)2.02354944
114Labial hypoplasia (HP:0000066)2.02144267
115Curly hair (HP:0002212)2.01898098
116Anal stenosis (HP:0002025)2.01828048
117Abnormal eating behavior (HP:0100738)2.01677230
118Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.01647930
119Bifid scrotum (HP:0000048)2.01159376
120Obstructive sleep apnea (HP:0002870)2.00827190
121Abnormality of the lower motor neuron (HP:0002366)1.99869032
122Hydroxyprolinuria (HP:0003080)1.98585307
123Abnormality of proline metabolism (HP:0010907)1.98585307
124Patellar dislocation (HP:0002999)1.98424357
125Spastic gait (HP:0002064)1.98150904
126Microretrognathia (HP:0000308)1.97909962
127Absent eyebrow (HP:0002223)1.97517456
128Pendular nystagmus (HP:0012043)1.95912646
129Abnormality of the phalanges of the hallux (HP:0010057)1.95755922
130Choroideremia (HP:0001139)1.95028758
131Corneal erosion (HP:0200020)1.94740635
132Hypoventilation (HP:0002791)1.94119363
133Abnormality of glycine metabolism (HP:0010895)1.93922199
134Abnormality of serine family amino acid metabolism (HP:0010894)1.93922199
135Megalocornea (HP:0000485)1.93865987
136Alopecia of scalp (HP:0002293)1.93528164
137Shoulder girdle muscle weakness (HP:0003547)1.92727964
138Hypoplastic female external genitalia (HP:0012815)1.92684178
139Abnormality of the distal phalanges of the toes (HP:0010182)1.92517672
140Abnormality of the lacrimal duct (HP:0011481)1.92512798
141Intestinal atresia (HP:0011100)1.92320592
142Congenital glaucoma (HP:0001087)1.92054967
143Abnormality of the vocal cords (HP:0008777)1.91765877
144Obsessive-compulsive behavior (HP:0000722)1.90932231
145Impaired vibration sensation in the lower limbs (HP:0002166)1.90490875
146Macroorchidism (HP:0000053)1.90426180
147Abnormality of renin-angiotensin system (HP:0000847)1.89360609
148Polyphagia (HP:0002591)1.88741258
149Abnormality of the gastric mucosa (HP:0004295)1.88438480
150Bicornuate uterus (HP:0000813)1.87680561
151Bronchomalacia (HP:0002780)1.87393907
152Intrahepatic cholestasis (HP:0001406)1.87174802
153Absent speech (HP:0001344)1.86229440
154Woolly hair (HP:0002224)1.86086486
155Double outlet right ventricle (HP:0001719)1.85867987
156Congenital malformation of the right heart (HP:0011723)1.85867987
157Abnormality of the diencephalon (HP:0010662)1.85796374
158Aplasia/hypoplasia of the humerus (HP:0006507)1.85357943
159Abdominal distention (HP:0003270)1.82242055
160Absent/shortened dynein arms (HP:0200106)1.82127284
161Dynein arm defect of respiratory motile cilia (HP:0012255)1.82127284
162Hemiparesis (HP:0001269)1.81709687
163Abnormality of chloride homeostasis (HP:0011422)1.81680588
164Seborrheic dermatitis (HP:0001051)1.81557850
165Stereotypic behavior (HP:0000733)1.81429513
166Fragile nails (HP:0001808)1.80547421
167Hyperthyroidism (HP:0000836)1.80379886
168Broad face (HP:0000283)1.80084737
169Pili torti (HP:0003777)1.79852064
170Adducted thumb (HP:0001181)1.78834225
171Segmental peripheral demyelination/remyelination (HP:0003481)1.78576724
172Heterotopia (HP:0002282)1.78135781
173Shawl scrotum (HP:0000049)1.78128432
174Asymmetry of the thorax (HP:0001555)1.78005075
175Neonatal hypoglycemia (HP:0001998)1.77905674
176Tracheal stenosis (HP:0002777)1.77805603
177Upper limb muscle weakness (HP:0003484)1.77764266
178Craniofacial dystonia (HP:0012179)1.74765185
179Absent hair (HP:0002298)1.74749402
180Focal dystonia (HP:0004373)1.74711524
181Follicular hyperkeratosis (HP:0007502)1.74699466
182Osteolytic defects of the phalanges of the hand (HP:0009771)1.74127314
183Osteolytic defects of the hand bones (HP:0009699)1.74127314
184Fat malabsorption (HP:0002630)1.74049606
185Rectal prolapse (HP:0002035)1.72019357
186Abnormality of the parathyroid morphology (HP:0011766)1.70342593
187Hypoplasia of dental enamel (HP:0006297)1.70257343
188Hypercalciuria (HP:0002150)1.69505848
189Abnormal ossification of hand bones (HP:0005921)1.68910899
190Selective tooth agenesis (HP:0001592)1.68675275
191Abnormality of monocarboxylic acid metabolism (HP:0010996)1.68642114
192Duplication of thumb phalanx (HP:0009942)1.67463398
193Thin bony cortex (HP:0002753)1.67038870
194Neonatal short-limb short stature (HP:0008921)1.66973489
195Hypoplasia of the ulna (HP:0003022)1.63658073

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.14162779
2EPHA24.96130306
3MAP3K94.10295572
4STK163.64626618
5MST1R3.60777064
6CAMK1D3.51853180
7MAP3K42.99479666
8EPHB22.87692521
9KSR12.70760074
10TRIB32.43775894
11MET2.40820399
12SMG12.28790146
13NTRK22.18763643
14MAPK152.06551530
15TGFBR12.05410295
16ACVR1B2.05336649
17NTRK31.96423090
18DYRK21.94590645
19MINK11.94415349
20TNIK1.85011754
21ARAF1.78061218
22UHMK11.75099469
23AKT31.75028616
24MAPK131.72379634
25PAK31.71022942
26EPHA31.70565077
27GRK51.67707285
28MARK21.62611383
29TESK11.61625262
30MAP2K71.56396335
31PHKG21.54080170
32PHKG11.54080170
33PAK61.52982634
34SIK21.47920136
35TESK21.44101409
36NTRK11.40287735
37PAK41.37972900
38RIPK11.35420367
39WNK31.33150872
40PIM21.31511762
41FGFR41.29302694
42CSNK1A1L1.28394591
43CSNK1G21.25739666
44CSNK1G31.24834189
45DAPK21.24520531
46SIK11.24127454
47BMPR1B1.15759902
48FES1.15458655
49LATS21.15215699
50PTK21.15061452
51PRKG21.12995048
52MUSK1.12187843
53PTK61.10491080
54CDK51.07403505
55BRAF1.07148958
56KSR21.06544265
57MATK1.02451621
58PRKD21.01149355
59ICK0.99526575
60ERBB40.98909409
61TAOK10.96618661
62ERBB20.96592009
63LATS10.96565916
64SCYL20.95944952
65NME10.95741357
66ERBB30.92935704
67PDGFRA0.91492226
68BCR0.90871117
69IRAK30.90544154
70TYRO30.90151063
71SGK2230.90049484
72SGK4940.90049484
73LIMK10.88915876
74EPHB10.87658849
75RPS6KA20.86620428
76CDC42BPA0.86430206
77BMX0.85496348
78CDK180.85375790
79RET0.84935957
80FGFR10.83369877
81CDK150.82685472
82MAP3K60.82362111
83CDK140.81774165
84PKN20.80943011
85MAP2K40.79979727
86CDK11A0.76544439
87IRAK20.74989080
88CDK120.72729136
89DDR20.72352250
90STK38L0.71048158
91FGR0.70423629
92NEK60.70239917
93STK110.69308581
94CSNK1G10.68732671
95EIF2AK20.67142882
96DAPK30.65742056
97ILK0.64538113
98FYN0.64482921
99ADRBK10.62761521
100PRKCI0.61313275
101STK240.60134027
102ROCK10.59554564
103CDK190.59276134
104PBK0.57996446
105FGFR20.57493300
106ADRBK20.52786053
107TNK20.52538467
108PRKD30.51524194
109CASK0.51096201
110PKN10.51044470
111DYRK30.51043580
112RPS6KA40.50249206
113PDK40.50128468
114PDK30.50128468
115EPHA40.49511536
116PRKCG0.47871305
117TGFBR20.47467243
118MAP3K20.46188378
119DYRK1B0.45666486
120PRKAA10.45291348
121PRKCZ0.45209426
122IRAK10.44999011
123LMTK20.44665535
124PRKCE0.43106050
125MAP2K10.41985513
126DYRK1A0.41978155
127MAP3K120.40407680
128CAMKK10.39976761
129WNK10.39607257
130MAP3K70.38884273
131MTOR0.38805298
132ROCK20.38568927
133GRK70.37902102
134MAP3K100.37825961
135EEF2K0.37369774
136FER0.36253524
137ERN10.36202546
138ALK0.36187191
139RPS6KB20.35925560
140PRKAA20.35623561
141MAP2K20.35362490
142TAF10.35245710
143TTN0.33255583
144GSK3A0.32675183
145LRRK20.32065194
146MAPK90.31797762
147CAMK1G0.31683694
148STK390.30585253
149TIE10.30365593
150CAMK10.28835937
151WNK40.28404488
152CAMK2A0.28107591
153MAPK120.27378946
154TTK0.27124235
155MAP3K80.25994808
156CAMK2G0.25568504
157CAMK2B0.24787572
158PDPK10.24556373

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.05658383
2Vitamin digestion and absorption_Homo sapiens_hsa049773.67551451
3Renin-angiotensin system_Homo sapiens_hsa046142.85911674
4Axon guidance_Homo sapiens_hsa043602.64927167
5Fat digestion and absorption_Homo sapiens_hsa049752.61997447
6Nicotine addiction_Homo sapiens_hsa050332.57134358
7Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.55352342
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.29854631
9Galactose metabolism_Homo sapiens_hsa000522.22897801
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.17174591
11Mineral absorption_Homo sapiens_hsa049782.12184610
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.09516330
13Fatty acid biosynthesis_Homo sapiens_hsa000612.05468135
14Glutamatergic synapse_Homo sapiens_hsa047242.01664622
15Synaptic vesicle cycle_Homo sapiens_hsa047211.99366525
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.98617693
17Morphine addiction_Homo sapiens_hsa050321.96659519
18GABAergic synapse_Homo sapiens_hsa047271.95220636
19Fructose and mannose metabolism_Homo sapiens_hsa000511.93997449
20Histidine metabolism_Homo sapiens_hsa003401.87479432
21Protein digestion and absorption_Homo sapiens_hsa049741.87267079
22Circadian entrainment_Homo sapiens_hsa047131.86252193
23Tight junction_Homo sapiens_hsa045301.84015284
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.83312178
25Dopaminergic synapse_Homo sapiens_hsa047281.82729990
26Arginine and proline metabolism_Homo sapiens_hsa003301.80834778
27Arginine biosynthesis_Homo sapiens_hsa002201.78671426
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.71956335
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.71652164
30Gap junction_Homo sapiens_hsa045401.70878843
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.70541353
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65793119
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.65374982
34Cocaine addiction_Homo sapiens_hsa050301.64219023
35Amphetamine addiction_Homo sapiens_hsa050311.62883142
36Long-term potentiation_Homo sapiens_hsa047201.62256491
37Cholinergic synapse_Homo sapiens_hsa047251.62242936
38Insulin secretion_Homo sapiens_hsa049111.59354491
39Type II diabetes mellitus_Homo sapiens_hsa049301.55707222
40Renin secretion_Homo sapiens_hsa049241.53907649
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.46576264
42Salivary secretion_Homo sapiens_hsa049701.44134386
43Bile secretion_Homo sapiens_hsa049761.44025945
44Taste transduction_Homo sapiens_hsa047421.43632032
45Linoleic acid metabolism_Homo sapiens_hsa005911.41489591
46Adherens junction_Homo sapiens_hsa045201.40888407
47Serotonergic synapse_Homo sapiens_hsa047261.40791288
48Olfactory transduction_Homo sapiens_hsa047401.39338768
49Colorectal cancer_Homo sapiens_hsa052101.35176285
50Starch and sucrose metabolism_Homo sapiens_hsa005001.34524086
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32396497
52GnRH signaling pathway_Homo sapiens_hsa049121.32223357
53Long-term depression_Homo sapiens_hsa047301.31144647
54Gastric acid secretion_Homo sapiens_hsa049711.28057587
55Ether lipid metabolism_Homo sapiens_hsa005651.27509928
56Arachidonic acid metabolism_Homo sapiens_hsa005901.26090242
57ErbB signaling pathway_Homo sapiens_hsa040121.25923430
58Phospholipase D signaling pathway_Homo sapiens_hsa040721.24981180
59Sulfur metabolism_Homo sapiens_hsa009201.24508108
60Biosynthesis of amino acids_Homo sapiens_hsa012301.22398848
61Melanogenesis_Homo sapiens_hsa049161.22198286
62Oxytocin signaling pathway_Homo sapiens_hsa049211.21738377
63Phenylalanine metabolism_Homo sapiens_hsa003601.18476815
64Estrogen signaling pathway_Homo sapiens_hsa049151.18385331
65Pyruvate metabolism_Homo sapiens_hsa006201.16965988
66Sphingolipid metabolism_Homo sapiens_hsa006001.16631583
67Calcium signaling pathway_Homo sapiens_hsa040201.16450234
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.16204584
69Retinol metabolism_Homo sapiens_hsa008301.15556180
70Wnt signaling pathway_Homo sapiens_hsa043101.15225762
71cAMP signaling pathway_Homo sapiens_hsa040241.15144132
72Fatty acid metabolism_Homo sapiens_hsa012121.13892647
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13595762
74Steroid biosynthesis_Homo sapiens_hsa001001.09772218
75Glioma_Homo sapiens_hsa052141.07758036
76Fatty acid degradation_Homo sapiens_hsa000711.07708821
77Pentose phosphate pathway_Homo sapiens_hsa000301.07499562
78Neurotrophin signaling pathway_Homo sapiens_hsa047221.07368422
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02958397
80Basal cell carcinoma_Homo sapiens_hsa052171.02839679
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01113650
82Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00669080
83Hippo signaling pathway_Homo sapiens_hsa043900.98228181
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.97727350
85PPAR signaling pathway_Homo sapiens_hsa033200.97256043
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96839364
87Vitamin B6 metabolism_Homo sapiens_hsa007500.95079213
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94914077
89Carbon metabolism_Homo sapiens_hsa012000.94143606
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93116753
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92399225
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90667278
93Dorso-ventral axis formation_Homo sapiens_hsa043200.89790334
94Alcoholism_Homo sapiens_hsa050340.87011798
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.86084282
96Asthma_Homo sapiens_hsa053100.85610696
97Oocyte meiosis_Homo sapiens_hsa041140.85561530
98Hedgehog signaling pathway_Homo sapiens_hsa043400.85462817
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85134327
100Renal cell carcinoma_Homo sapiens_hsa052110.84065837
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83515651
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83117672
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82944994
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82053492
105Endometrial cancer_Homo sapiens_hsa052130.81983241
106Ras signaling pathway_Homo sapiens_hsa040140.81917980
107Insulin signaling pathway_Homo sapiens_hsa049100.81682027
108Nitrogen metabolism_Homo sapiens_hsa009100.80654831
109Viral myocarditis_Homo sapiens_hsa054160.80078554
110Chemical carcinogenesis_Homo sapiens_hsa052040.80007873
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79475493
112ECM-receptor interaction_Homo sapiens_hsa045120.78965425
113Choline metabolism in cancer_Homo sapiens_hsa052310.78920775
114Phototransduction_Homo sapiens_hsa047440.77514904
115Glutathione metabolism_Homo sapiens_hsa004800.77267200
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77212814
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.77114336
118Caffeine metabolism_Homo sapiens_hsa002320.76998364
119Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75538637
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75096201
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.73700713
122Tryptophan metabolism_Homo sapiens_hsa003800.73077758
123Glycerolipid metabolism_Homo sapiens_hsa005610.70245092
124Rap1 signaling pathway_Homo sapiens_hsa040150.70163344
125Thyroid cancer_Homo sapiens_hsa052160.69208799
126Thyroid hormone synthesis_Homo sapiens_hsa049180.68926373
127Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68432675
128Drug metabolism - other enzymes_Homo sapiens_hsa009830.68010266
129Amoebiasis_Homo sapiens_hsa051460.67323464
130Butanoate metabolism_Homo sapiens_hsa006500.66097304
131Dilated cardiomyopathy_Homo sapiens_hsa054140.64291138
132MicroRNAs in cancer_Homo sapiens_hsa052060.63614539
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62816572
134VEGF signaling pathway_Homo sapiens_hsa043700.61934715
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61429489
136Prion diseases_Homo sapiens_hsa050200.61362589
137Sulfur relay system_Homo sapiens_hsa041220.61105882
138MAPK signaling pathway_Homo sapiens_hsa040100.60958046
139Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59702602
140Focal adhesion_Homo sapiens_hsa045100.58583090
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58212971
142Central carbon metabolism in cancer_Homo sapiens_hsa052300.56917026
143B cell receptor signaling pathway_Homo sapiens_hsa046620.56105130
144Glucagon signaling pathway_Homo sapiens_hsa049220.52949110
145Tyrosine metabolism_Homo sapiens_hsa003500.52004390
146Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51762000
147Platelet activation_Homo sapiens_hsa046110.51553992
148Chemokine signaling pathway_Homo sapiens_hsa040620.50967438
149AMPK signaling pathway_Homo sapiens_hsa041520.50896877
150Endocytosis_Homo sapiens_hsa041440.50844667
151mTOR signaling pathway_Homo sapiens_hsa041500.50734721
152Proteoglycans in cancer_Homo sapiens_hsa052050.49040868
153Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48282024
154Notch signaling pathway_Homo sapiens_hsa043300.48141995
155Vibrio cholerae infection_Homo sapiens_hsa051100.47341968
156Selenocompound metabolism_Homo sapiens_hsa004500.46610925
157Cysteine and methionine metabolism_Homo sapiens_hsa002700.46187075
158Salmonella infection_Homo sapiens_hsa051320.46024523
159Lysine degradation_Homo sapiens_hsa003100.45928299
160Propanoate metabolism_Homo sapiens_hsa006400.44926427
161Pancreatic secretion_Homo sapiens_hsa049720.44905296
162Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44880904
163Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44453052
164Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43722547
165Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42972151
166Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42143906
167Ovarian steroidogenesis_Homo sapiens_hsa049130.41841814
168Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38005777
169Fatty acid elongation_Homo sapiens_hsa000620.34283255
170Maturity onset diabetes of the young_Homo sapiens_hsa049500.34067594
171Metabolic pathways_Homo sapiens_hsa011000.32681619
172beta-Alanine metabolism_Homo sapiens_hsa004100.32275610

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