GPRC5C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.76593292
2L-phenylalanine catabolic process (GO:0006559)6.76593292
3L-phenylalanine metabolic process (GO:0006558)6.55481956
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.55481956
5aromatic amino acid family catabolic process (GO:0009074)6.33994203
6glyoxylate metabolic process (GO:0046487)6.10204967
7cysteine metabolic process (GO:0006534)6.08598540
8indole-containing compound catabolic process (GO:0042436)5.99090622
9indolalkylamine catabolic process (GO:0046218)5.99090622
10tryptophan catabolic process (GO:0006569)5.99090622
11tryptophan metabolic process (GO:0006568)5.73229813
12kynurenine metabolic process (GO:0070189)5.59438391
13serine family amino acid catabolic process (GO:0009071)5.55755371
14sulfur amino acid catabolic process (GO:0000098)5.42293805
15lysine catabolic process (GO:0006554)5.39115872
16lysine metabolic process (GO:0006553)5.39115872
17urate metabolic process (GO:0046415)5.21666584
18epoxygenase P450 pathway (GO:0019373)5.15240066
19bile acid biosynthetic process (GO:0006699)5.07214629
20homocysteine metabolic process (GO:0050667)4.95640784
21drug transmembrane transport (GO:0006855)4.91201461
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.90826489
23amino-acid betaine metabolic process (GO:0006577)4.89845621
24urea cycle (GO:0000050)4.76221393
25urea metabolic process (GO:0019627)4.76221393
26triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.73919925
27aromatic amino acid family metabolic process (GO:0009072)4.67519926
28protein carboxylation (GO:0018214)4.56861881
29peptidyl-glutamic acid carboxylation (GO:0017187)4.56861881
30serine family amino acid metabolic process (GO:0009069)4.56780033
31regulation of protein activation cascade (GO:2000257)4.52885299
32complement activation, alternative pathway (GO:0006957)4.51456811
33alpha-linolenic acid metabolic process (GO:0036109)4.47216731
34intestinal cholesterol absorption (GO:0030299)4.42721161
35alpha-amino acid catabolic process (GO:1901606)4.41299847
36high-density lipoprotein particle remodeling (GO:0034375)4.41000896
37negative regulation of fibrinolysis (GO:0051918)4.40843107
38nitrogen cycle metabolic process (GO:0071941)4.39307097
39drug catabolic process (GO:0042737)4.38106891
40bile acid metabolic process (GO:0008206)4.33620838
41glycine metabolic process (GO:0006544)4.29003065
42regulation of complement activation (GO:0030449)4.27676479
43regulation of fibrinolysis (GO:0051917)4.24109581
44cellular modified amino acid catabolic process (GO:0042219)4.22698269
45indolalkylamine metabolic process (GO:0006586)4.22230963
46blood coagulation, intrinsic pathway (GO:0007597)4.20028993
47cellular amino acid catabolic process (GO:0009063)4.16281051
48cellular glucuronidation (GO:0052695)4.15794612
49drug transport (GO:0015893)4.15399852
50cellular biogenic amine catabolic process (GO:0042402)4.11790011
51amine catabolic process (GO:0009310)4.11790011
52proline metabolic process (GO:0006560)4.11727293
53tyrosine metabolic process (GO:0006570)4.09997551
54benzene-containing compound metabolic process (GO:0042537)4.08399644
55ethanol metabolic process (GO:0006067)4.03026840
56serine family amino acid biosynthetic process (GO:0009070)4.02763932
57exogenous drug catabolic process (GO:0042738)3.97097756
58regulation of plasminogen activation (GO:0010755)3.95249398
59phenylpropanoid metabolic process (GO:0009698)3.93617147
60reverse cholesterol transport (GO:0043691)3.92268021
61glutamate metabolic process (GO:0006536)3.86095432
622-oxoglutarate metabolic process (GO:0006103)3.85782020
63uronic acid metabolic process (GO:0006063)3.84584341
64glucuronate metabolic process (GO:0019585)3.84584341
65acylglycerol homeostasis (GO:0055090)3.81137997
66triglyceride homeostasis (GO:0070328)3.81137997
67regulation of cholesterol esterification (GO:0010872)3.81000407
68short-chain fatty acid metabolic process (GO:0046459)3.80395838
69omega-hydroxylase P450 pathway (GO:0097267)3.79269411
70very-low-density lipoprotein particle assembly (GO:0034379)3.78806367
71plasma lipoprotein particle remodeling (GO:0034369)3.78776829
72protein-lipid complex remodeling (GO:0034368)3.78776829
73macromolecular complex remodeling (GO:0034367)3.78776829
74cholesterol efflux (GO:0033344)3.78428954
75coenzyme catabolic process (GO:0009109)3.77163132
76valine metabolic process (GO:0006573)3.76212815
77cellular ketone body metabolic process (GO:0046950)3.74723414
78organic acid catabolic process (GO:0016054)3.72575101
79carboxylic acid catabolic process (GO:0046395)3.72575101
80carnitine metabolic process (GO:0009437)3.72521871
81regulation of triglyceride catabolic process (GO:0010896)3.70194783
82aldehyde catabolic process (GO:0046185)3.70187325
83bile acid and bile salt transport (GO:0015721)3.69863082
84negative regulation of lipase activity (GO:0060192)3.68534950
85negative regulation of cholesterol transport (GO:0032375)3.67527117
86negative regulation of sterol transport (GO:0032372)3.67527117
87response to mercury ion (GO:0046689)3.66638550
88fatty acid oxidation (GO:0019395)3.63929159
89aspartate family amino acid catabolic process (GO:0009068)3.62432690
90fatty acid beta-oxidation (GO:0006635)3.61453848
91response to nitrosative stress (GO:0051409)3.60078387
92imidazole-containing compound metabolic process (GO:0052803)3.59769606
93ethanol oxidation (GO:0006069)3.59085354
94primary alcohol catabolic process (GO:0034310)3.57747920
95negative regulation of protein activation cascade (GO:2000258)3.57684087
96lung epithelium development (GO:0060428)3.57145757
97lipid oxidation (GO:0034440)3.57045162
98acetyl-CoA metabolic process (GO:0006084)3.56961215
99flavonoid metabolic process (GO:0009812)3.55191504
100regulation of cholesterol homeostasis (GO:2000188)3.52178863
101acute-phase response (GO:0006953)3.47819152
102phospholipid efflux (GO:0033700)3.46048656
103monocarboxylic acid catabolic process (GO:0072329)3.45202809
104fibrinolysis (GO:0042730)3.44302598
105plasma lipoprotein particle assembly (GO:0034377)3.43655175
106negative regulation of hemostasis (GO:1900047)3.41673693
107negative regulation of blood coagulation (GO:0030195)3.41673693
108plasma lipoprotein particle clearance (GO:0034381)3.40069431
109regulation of bile acid biosynthetic process (GO:0070857)3.38658788
110positive regulation of triglyceride lipase activity (GO:0061365)3.37817472
111positive regulation of lipoprotein lipase activity (GO:0051006)3.37817472
112regulation of cholesterol metabolic process (GO:0090181)3.36305444
113fatty acid catabolic process (GO:0009062)3.35983580
114arginine metabolic process (GO:0006525)3.35002763
115heme transport (GO:0015886)3.34656060
116drug metabolic process (GO:0017144)3.31835916
117branched-chain amino acid metabolic process (GO:0009081)3.30745230
118phospholipid homeostasis (GO:0055091)3.30115691
119low-density lipoprotein particle remodeling (GO:0034374)3.28104966
120dicarboxylic acid biosynthetic process (GO:0043650)3.27253368
121protein activation cascade (GO:0072376)3.25883895
122xenobiotic catabolic process (GO:0042178)3.24468820
123plasma lipoprotein particle organization (GO:0071827)3.21077889
124negative regulation of coagulation (GO:0050819)3.19226544
125positive regulation of hormone metabolic process (GO:0032352)3.14297138
126cholesterol homeostasis (GO:0042632)3.12561344
127oxidative demethylation (GO:0070989)3.11043982
128negative regulation of wound healing (GO:0061045)3.07997262
129sterol homeostasis (GO:0055092)3.07988832
130protein-lipid complex assembly (GO:0065005)3.07553679
131calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.05938796
132regulation of apoptotic cell clearance (GO:2000425)3.03170451
133negative regulation of complement activation (GO:0045916)3.03021111
134protein-lipid complex subunit organization (GO:0071825)3.02754484
135phosphate ion transmembrane transport (GO:0035435)3.00122676
136complement activation, classical pathway (GO:0006958)2.99849324
137positive regulation of cellular amine metabolic process (GO:0033240)2.97726012
138intestinal absorption (GO:0050892)2.96089177
139daunorubicin metabolic process (GO:0044597)2.95040499
140polyketide metabolic process (GO:0030638)2.95040499
141doxorubicin metabolic process (GO:0044598)2.95040499
142regulation of humoral immune response (GO:0002920)2.94406017
143regulation of cholesterol biosynthetic process (GO:0045540)2.93724661

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.77590199
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.73228264
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.04216515
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.95134629
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.00249539
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.63869188
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.60303647
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.60391526
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.54081629
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33788176
11GATA1_22025678_ChIP-Seq_K562_Human2.23567880
12CLOCK_20551151_ChIP-Seq_293T_Human2.17429580
13* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.16253999
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00381249
15* ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.8469768
16* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.99760789
17RARG_19884340_ChIP-ChIP_MEFs_Mouse1.92533787
18* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.90747392
19* ESR1_21235772_ChIP-Seq_MCF-7_Human1.73410083
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.63543856
21* ERG_21242973_ChIP-ChIP_JURKAT_Human1.63522347
22CTCF_27219007_Chip-Seq_Bcells_Human1.62054605
23ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.54957272
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.53563035
25FOXA2_19822575_ChIP-Seq_HepG2_Human1.49993643
26SRY_22984422_ChIP-ChIP_TESTIS_Rat1.45679675
27* HNF4A_19822575_ChIP-Seq_HepG2_Human1.42320628
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.39696383
29* ESR2_21235772_ChIP-Seq_MCF-7_Human1.38760433
30SOX2_27498859_Chip-Seq_STOMACH_Mouse1.36761839
31GATA4_25053715_ChIP-Seq_YYC3_Human1.35951625
32* RUNX1_27514584_Chip-Seq_MCF-7_Human1.31537988
33* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31445208
34SMC4_20622854_ChIP-Seq_HELA_Human1.31308909
35SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30695331
36P68_20966046_ChIP-Seq_HELA_Human1.30031107
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20456541
38ZNF263_19887448_ChIP-Seq_K562_Human1.17181025
39IRF8_22096565_ChIP-ChIP_GC-B_Human1.16243206
40SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14719684
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14532005
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13774066
43PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11670755
44SA1_27219007_Chip-Seq_Bcells_Human1.11295505
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11151498
46RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09546652
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09159768
48* CREB1_26743006_Chip-Seq_LNCaP_Human1.08243737
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08118329
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05670383
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02220272
52* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01182487
53* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00987743
54CDX2_20551321_ChIP-Seq_CACO-2_Human0.99948065
55ESR1_20079471_ChIP-ChIP_T-47D_Human0.99443503
56STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99125060
57ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99040657
58AR_21909140_ChIP-Seq_LNCAP_Human0.97157219
59STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97056433
60CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96782690
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96207577
62* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95852508
63P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95633665
64KAP1_22055183_ChIP-Seq_ESCs_Mouse0.94877922
65NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94152753
66* SA1_27219007_Chip-Seq_ERYTHROID_Human0.93835627
67PHF8_20622854_ChIP-Seq_HELA_Human0.93717357
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92793635
69SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92607526
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92316496
71E2F1_20622854_ChIP-Seq_HELA_Human0.91012357
72BCOR_27268052_Chip-Seq_Bcells_Human0.90553255
73CTCF_20526341_ChIP-Seq_ESCs_Human0.89558192
74TP63_22573176_ChIP-Seq_HFKS_Human0.89554224
75NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.88761318
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88259573
77FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87736027
78* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87726586
79JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.84182105
80* EZH2_27294783_Chip-Seq_ESCs_Mouse0.83172926
81SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82405482
82* GATA6_25053715_ChIP-Seq_YYC3_Human0.82190137
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.81645481
84FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81571195
85SOX2_21211035_ChIP-Seq_LN229_Human0.81306771
86P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.80911464
87EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.80331323
88AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80027785
89* KDM2B_26808549_Chip-Seq_K562_Human0.79620712
90GATA3_21867929_ChIP-Seq_CD8_Mouse0.79307377
91RACK7_27058665_Chip-Seq_MCF-7_Human0.76744412
92TP63_17297297_ChIP-ChIP_HaCaT_Human0.76399022
93* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.75571085
94POU5F1_16518401_ChIP-PET_MESCs_Mouse0.75035310
95TP53_20018659_ChIP-ChIP_R1E_Mouse0.74950603
96RARA_24833708_ChIP-Seq_LIVER_Mouse0.74795346
97TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74075597
98HTT_18923047_ChIP-ChIP_STHdh_Human0.73956736
99BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.73012735
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72334921
101SOX2_20726797_ChIP-Seq_SW620_Human0.72033475
102ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.69594480
103GATA3_24758297_ChIP-Seq_MCF-7_Human0.68496626
104PPAR_26484153_Chip-Seq_NCI-H1993_Human0.68225047
105SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.67109008
106RARB_24833708_ChIP-Seq_LIVER_Mouse0.66779218
107CEBPB_22108803_ChIP-Seq_LS180_Human0.65328879
108ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.63190028
109ESR1_15608294_ChIP-ChIP_MCF-7_Human0.62893940
110FOXO3_23340844_ChIP-Seq_DLD1_Human0.62410219
111AR_20517297_ChIP-Seq_VCAP_Human0.62226120
112* LXR_22292898_ChIP-Seq_THP-1_Human0.61003689
113GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.60593797
114* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.60477270
115STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.59440019
116NRF2_20460467_ChIP-Seq_MEFs_Mouse0.58772316
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.58772316
118* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.56808092
119PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.56551369
120* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.55203545
121* FOXA1_25552417_ChIP-Seq_VCAP_Human0.54258654
122RAC3_21632823_ChIP-Seq_H3396_Human0.54228949
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.54105813
124RAD21_21589869_ChIP-Seq_MESCs_Mouse0.53824499
125SOX2_18692474_ChIP-Seq_MEFs_Mouse0.53557138
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.53476434
127* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.53066577
128AUTS2_25519132_ChIP-Seq_293T-REX_Human0.52886000
129KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.52056773
130STAT1_17558387_ChIP-Seq_HELA_Human0.51799998
131ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.51739851
132CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.51066008
133EGR1_19032775_ChIP-ChIP_M12_Human0.50800773
134GATA1_19941826_ChIP-Seq_K562_Human0.50560446
135CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.50406069
136* ATF3_27146783_Chip-Seq_COLON_Human0.50093383
137TET1_21451524_ChIP-Seq_MESCs_Mouse0.49556465
138TRIM28_21343339_ChIP-Seq_HEK293_Human0.48735569
139SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.48013003
140MYC_19915707_ChIP-ChIP_AK7_Human0.47889434
141ERG_20517297_ChIP-Seq_VCAP_Human0.47294434
142GATA2_21666600_ChIP-Seq_HMVEC_Human0.47150165

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.41160106
2MP0005360_urolithiasis7.07755216
3MP0005365_abnormal_bile_salt5.34045425
4MP0005085_abnormal_gallbladder_physiolo5.32668563
5MP0008875_abnormal_xenobiotic_pharmacok4.48022589
6MP0003806_abnormal_nucleotide_metabolis3.74566606
7MP0003252_abnormal_bile_duct3.71350750
8MP0003195_calcinosis3.44722409
9MP0005332_abnormal_amino_acid3.23728916
10MP0004019_abnormal_vitamin_homeostasis3.18209298
11MP0000566_synostosis3.06161952
12MP0002138_abnormal_hepatobiliary_system2.88166065
13MP0010329_abnormal_lipoprotein_level2.82940579
14MP0009840_abnormal_foam_cell2.65524389
15MP0005083_abnormal_biliary_tract2.50362082
16MP0001666_abnormal_nutrient_absorption2.40882346
17MP0003191_abnormal_cellular_cholesterol2.20276673
18MP0009643_abnormal_urine_homeostasis2.12382239
19MP0010030_abnormal_orbit_morphology2.08860696
20MP0005319_abnormal_enzyme/_coenzyme1.86337589
21MP0000609_abnormal_liver_physiology1.85953767
22MP0003186_abnormal_redox_activity1.76903384
23MP0009780_abnormal_chondrocyte_physiolo1.74426092
24MP0002118_abnormal_lipid_homeostasis1.72867067
25MP0005636_abnormal_mineral_homeostasis1.63924512
26MP0004043_abnormal_pH_regulation1.61110550
27MP0003879_abnormal_hair_cell1.59562576
28MP0001756_abnormal_urination1.47101172
29MP0005584_abnormal_enzyme/coenzyme_acti1.46166378
30MP0001764_abnormal_homeostasis1.44728154
31MP0003868_abnormal_feces_composition1.44395482
32MP0002249_abnormal_larynx_morphology1.41051780
33MP0005084_abnormal_gallbladder_morpholo1.32601174
34MP0005451_abnormal_body_composition1.31207306
35MP0002089_abnormal_postnatal_growth/wei1.29156275
36MP0003122_maternal_imprinting1.28534660
37MP0002136_abnormal_kidney_physiology1.23754977
38MP0006292_abnormal_olfactory_placode1.17556049
39MP0000598_abnormal_liver_morphology1.15912750
40MP0005220_abnormal_exocrine_pancreas1.14131376
41MP0004264_abnormal_extraembryonic_tissu1.11872938
42MP0005670_abnormal_white_adipose1.09708709
43MP0002876_abnormal_thyroid_physiology1.09581663
44MP0009697_abnormal_copulation1.06673555
45MP0003938_abnormal_ear_development1.06390422
46MP0001765_abnormal_ion_homeostasis1.04825699
47MP0005058_abnormal_lysosome_morphology1.03943962
48MP0009764_decreased_sensitivity_to1.03152696
49MP0003705_abnormal_hypodermis_morpholog1.02884765
50MP0005408_hypopigmentation1.02718898
51MP0010368_abnormal_lymphatic_system1.00017843
52MP0002928_abnormal_bile_duct0.99161191
53MP0000003_abnormal_adipose_tissue0.95223370
54MP0009053_abnormal_anal_canal0.91640911
55MP0004133_heterotaxia0.91334238
56MP0002909_abnormal_adrenal_gland0.91200301
57MP0009642_abnormal_blood_homeostasis0.88808154
58MP0003656_abnormal_erythrocyte_physiolo0.88092034
59MP0006036_abnormal_mitochondrial_physio0.86634619
60MP0008469_abnormal_protein_level0.85738987
61MP0002254_reproductive_system_inflammat0.85474964
62MP0005647_abnormal_sex_gland0.84999001
63MP0000537_abnormal_urethra_morphology0.84803485
64MP0009763_increased_sensitivity_to0.83312704
65MP0003011_delayed_dark_adaptation0.80530782
66MP0002282_abnormal_trachea_morphology0.78768896
67MP0003123_paternal_imprinting0.77711403
68MP0000467_abnormal_esophagus_morphology0.76492764
69MP0005395_other_phenotype0.74957546
70MP0003718_maternal_effect0.72597369
71MP0002135_abnormal_kidney_morphology0.72194389
72MP0001661_extended_life_span0.71670225
73MP0010386_abnormal_urinary_bladder0.70045111
74MP0002078_abnormal_glucose_homeostasis0.69975246
75MP0008872_abnormal_physiological_respon0.69586128
76MP0000681_abnormal_thyroid_gland0.69473580
77MP0000762_abnormal_tongue_morphology0.68404914
78MP0003283_abnormal_digestive_organ0.68272452
79MP0003878_abnormal_ear_physiology0.68118377
80MP0005377_hearing/vestibular/ear_phenot0.68118377
81MP0000013_abnormal_adipose_tissue0.66995937
82MP0004145_abnormal_muscle_electrophysio0.66044908
83MP0005666_abnormal_adipose_tissue0.65486444
84MP0004782_abnormal_surfactant_physiolog0.65386992
85MP0005330_cardiomyopathy0.65015538
86MP0009765_abnormal_xenobiotic_induced0.64374453
87MP0005376_homeostasis/metabolism_phenot0.63565834
88MP0002697_abnormal_eye_size0.63447996
89MP0004858_abnormal_nervous_system0.61166479
90MP0002168_other_aberrant_phenotype0.60562720
91MP0002971_abnormal_brown_adipose0.58990189
92MP0002132_abnormal_respiratory_system0.58875551
93MP0000538_abnormal_urinary_bladder0.58688135
94MP0001502_abnormal_circadian_rhythm0.57033343
95MP0005023_abnormal_wound_healing0.55786566
96MP0001542_abnormal_bone_strength0.54634522
97MP0000678_abnormal_parathyroid_gland0.54404626
98MP0002896_abnormal_bone_mineralization0.53710846
99MP0000049_abnormal_middle_ear0.52700623
100MP0005076_abnormal_cell_differentiation0.52695456
101MP0006138_congestive_heart_failure0.51533715
102MP0005266_abnormal_metabolism0.51448179
103MP0004147_increased_porphyrin_level0.51250039
104MP0009672_abnormal_birth_weight0.49809235
105MP0000751_myopathy0.49763952
106MP0003638_abnormal_response/metabolism_0.48331787
107MP0004130_abnormal_muscle_cell0.48056240
108MP0003453_abnormal_keratinocyte_physiol0.47985257
109MP0005334_abnormal_fat_pad0.47527550
110MP0001346_abnormal_lacrimal_gland0.47245176
111MP0005375_adipose_tissue_phenotype0.47081857
112MP0004272_abnormal_basement_membrane0.46872888
113MP0001915_intracranial_hemorrhage0.46717679
114MP0000639_abnormal_adrenal_gland0.46640373
115MP0003300_gastrointestinal_ulcer0.46631441
116MP0001944_abnormal_pancreas_morphology0.46306659
117MP0002233_abnormal_nose_morphology0.46270293
118MP0000230_abnormal_systemic_arterial0.45859216
119MP0001286_abnormal_eye_development0.45276845
120MP0000604_amyloidosis0.44882251
121MP0002098_abnormal_vibrissa_morphology0.44495603
122MP0009384_cardiac_valve_regurgitation0.44281606
123MP0003953_abnormal_hormone_level0.42041182
124MP0003724_increased_susceptibility_to0.40182074
125MP0005535_abnormal_body_temperature0.39078748
126MP0001881_abnormal_mammary_gland0.38780973
127MP0009115_abnormal_fat_cell0.34309013
128MP0002269_muscular_atrophy0.33932083
129MP0010234_abnormal_vibrissa_follicle0.33144238
130MP0003942_abnormal_urinary_system0.32631221
131MP0005464_abnormal_platelet_physiology0.31675593
132MP0001845_abnormal_inflammatory_respons0.31666187
133MP0003436_decreased_susceptibility_to0.29916271
134MP0006035_abnormal_mitochondrial_morpho0.29850768
135MP0002796_impaired_skin_barrier0.29744381
136MP0002115_abnormal_skeleton_extremities0.29306707
137MP0002295_abnormal_pulmonary_circulatio0.26479163
138MP0003943_abnormal_hepatobiliary_system0.26124787
139MP0002092_abnormal_eye_morphology0.25966440

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.03120042
2Intrahepatic cholestasis (HP:0001406)5.68193932
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.53659240
4Deep venous thrombosis (HP:0002625)5.38442898
5Prolonged partial thromboplastin time (HP:0003645)5.02967511
6Hyperglycinuria (HP:0003108)4.99579767
7Xanthomatosis (HP:0000991)4.98480876
8Gout (HP:0001997)4.77906286
9Hyperglycinemia (HP:0002154)4.71738120
10Abnormality of glutamine family amino acid metabolism (HP:0010902)4.61650852
11Hypobetalipoproteinemia (HP:0003563)4.42553845
12Abnormality of glycine metabolism (HP:0010895)4.40767108
13Abnormality of serine family amino acid metabolism (HP:0010894)4.40767108
14Ketosis (HP:0001946)4.25711863
15Complement deficiency (HP:0004431)4.10981208
16Hyperammonemia (HP:0001987)4.10036931
17Abnormality of sulfur amino acid metabolism (HP:0004339)4.08446277
18Abnormality of aspartate family amino acid metabolism (HP:0010899)4.07210898
19Hyperlipoproteinemia (HP:0010980)3.90785323
20Abnormality of purine metabolism (HP:0004352)3.87104133
21Joint hemorrhage (HP:0005261)3.86119573
22Hypoglycemic coma (HP:0001325)3.85542585
23Abnormality of fatty-acid metabolism (HP:0004359)3.71046254
24Abnormality of nucleobase metabolism (HP:0010932)3.66467930
25Proximal tubulopathy (HP:0000114)3.57505274
26Abnormality of methionine metabolism (HP:0010901)3.55939689
27Hypolipoproteinemia (HP:0010981)3.47025137
28Abnormality of the common coagulation pathway (HP:0010990)3.41769855
29Hemorrhage of the eye (HP:0011885)3.40475415
30Fat malabsorption (HP:0002630)3.40033832
31Ketoacidosis (HP:0001993)3.38491827
32Increased purine levels (HP:0004368)3.32635236
33Hyperuricemia (HP:0002149)3.32635236
34Abnormality of pyrimidine metabolism (HP:0004353)3.25195524
35Generalized aminoaciduria (HP:0002909)3.23956625
36Epidermoid cyst (HP:0200040)3.20519903
37Hypoalphalipoproteinemia (HP:0003233)3.16956009
38Abnormality of serum amino acid levels (HP:0003112)3.16458853
39Delayed CNS myelination (HP:0002188)3.14572449
40Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.14491882
41Abnormality of the intrinsic pathway (HP:0010989)3.05800342
42Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.05544940
43Vascular calcification (HP:0004934)3.04539783
44Conjugated hyperbilirubinemia (HP:0002908)3.03759273
45Alkalosis (HP:0001948)3.00410626
46Abnormality of dicarboxylic acid metabolism (HP:0010995)2.94657266
47Dicarboxylic aciduria (HP:0003215)2.94657266
48Abnormality of complement system (HP:0005339)2.93280028
49Hepatocellular carcinoma (HP:0001402)2.87616873
50Hyperbilirubinemia (HP:0002904)2.83207216
51Flat acetabular roof (HP:0003180)2.76141796
52Lethargy (HP:0001254)2.70356707
53Hyperactive renin-angiotensin system (HP:0000841)2.69875067
54Metabolic acidosis (HP:0001942)2.67728129
55Cardiovascular calcification (HP:0011915)2.65473992
56Enlarged kidneys (HP:0000105)2.64828367
57Hypokalemic alkalosis (HP:0001949)2.64422026
58Abnormality of urine glucose concentration (HP:0011016)2.61993315
59Glycosuria (HP:0003076)2.61993315
60Steatorrhea (HP:0002570)2.60750718
61Hypercholesterolemia (HP:0003124)2.56758474
62Esophageal varix (HP:0002040)2.54218520
63Nephritis (HP:0000123)2.53977175
64Malnutrition (HP:0004395)2.48037506
65Late onset (HP:0003584)2.46705898
66Hypoglycemic seizures (HP:0002173)2.46181990
67Abnormality of proline metabolism (HP:0010907)2.45379049
68Hydroxyprolinuria (HP:0003080)2.45379049
69Rickets (HP:0002748)2.41454227
70Increased circulating renin level (HP:0000848)2.40096935
71Abnormality of chloride homeostasis (HP:0011422)2.38328459
72Abnormal enzyme/coenzyme activity (HP:0012379)2.38281014
73Systemic lupus erythematosus (HP:0002725)2.35612882
74Irritability (HP:0000737)2.32950189
75Abnormal urine output (HP:0012590)2.29973859
76Spastic diplegia (HP:0001264)2.27374332
77Metabolic alkalosis (HP:0200114)2.25195630
78Bronchomalacia (HP:0002780)2.25100652
79Abnormality of renal excretion (HP:0011036)2.24614723
80Myocardial infarction (HP:0001658)2.23043418
81Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.20916916
82Polyuria (HP:0000103)2.20905828
83Abnormality of alkaline phosphatase activity (HP:0004379)2.19281148
84Vomiting (HP:0002013)2.18172138
85Neonatal onset (HP:0003623)2.15957791
86Menorrhagia (HP:0000132)2.13997416
87Nephrolithiasis (HP:0000787)2.12439276
88Pancreatitis (HP:0001733)2.12429451
89Focal segmental glomerulosclerosis (HP:0000097)2.09773329
90Hypomagnesemia (HP:0002917)2.09023712
91Glomerulonephritis (HP:0000099)2.06685848
92Mitral stenosis (HP:0001718)2.04979390
93Glomerulosclerosis (HP:0000096)2.04367314
94Hypochromic microcytic anemia (HP:0004840)2.03721957
95Spontaneous abortion (HP:0005268)2.01993290
96Exercise-induced myalgia (HP:0003738)2.00807009
97Elevated alkaline phosphatase (HP:0003155)1.99740674
98Right ventricular cardiomyopathy (HP:0011663)1.99345844
99Nausea (HP:0002018)1.97051394
100Hypophosphatemic rickets (HP:0004912)1.96483885
101Bifid scrotum (HP:0000048)1.96477950
102Abnormality of the Achilles tendon (HP:0005109)1.96146289
103Renal tubular acidosis (HP:0001947)1.96009122
104Osteomalacia (HP:0002749)1.94711184
105Chondrocalcinosis (HP:0000934)1.94673726
106Goiter (HP:0000853)1.94434313
107Synostosis involving the elbow (HP:0003938)1.93367438
108Humeroradial synostosis (HP:0003041)1.93367438
109Abnormality of carpal bone ossification (HP:0006257)1.93080590
110Abnormality of magnesium homeostasis (HP:0004921)1.92525510
111Potter facies (HP:0002009)1.92104423
112Facial shape deformation (HP:0011334)1.92104423
113Hyperinsulinemic hypoglycemia (HP:0000825)1.89811037
114Hyperphosphaturia (HP:0003109)1.89267436
115Hypophosphatemia (HP:0002148)1.88931850
116Purpura (HP:0000979)1.87064135
117Skin nodule (HP:0200036)1.87012844
118Abnormal tarsal ossification (HP:0008369)1.86948150
119Athetosis (HP:0002305)1.86883142
120Abnormality of the nasal septum (HP:0000419)1.85187467
121Abnormality of Sharpey fibers (HP:0100685)1.85161479
122Lymphangioma (HP:0100764)1.81724249
123Reduced antithrombin III activity (HP:0001976)1.79840844
124Myopathic facies (HP:0002058)1.79116181
125Abnormal urine phosphate concentration (HP:0012599)1.77832039
126Abnormality of the vitreous humor (HP:0004327)1.76627624
127Abnormal hair laboratory examination (HP:0003328)1.75448812
128Rhabdomyolysis (HP:0003201)1.73920999
129Choanal stenosis (HP:0000452)1.71147887
130Hypotension (HP:0002615)1.67256340
131Popliteal pterygium (HP:0009756)1.64950724
132Retinal atrophy (HP:0001105)1.63532799
133Pterygium (HP:0001059)1.61730833
134Chronic bronchitis (HP:0004469)1.61586009
135Abnormality of the pubic bones (HP:0003172)1.59912973
136Thyroid-stimulating hormone excess (HP:0002925)1.56493651
137Abnormality of the lacrimal duct (HP:0011481)1.54829213
138Amelogenesis imperfecta (HP:0000705)1.54703110
139Hypercalciuria (HP:0002150)1.53019248
140Vaginal fistula (HP:0004320)1.52344989

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.90961548
2WNK33.55955340
3WNK43.40566129
4ERN13.35682660
5SIK12.90441203
6STK38L2.90266719
7FGFR42.68397468
8INSRR2.57737418
9ICK2.22412051
10EPHA22.16712666
11LATS12.13301555
12OXSR12.11818472
13TAOK32.11074699
14AKT32.05504833
15FRK2.01255107
16LMTK22.01239840
17PHKG11.94135270
18PHKG21.94135270
19FLT31.90515132
20KDR1.79174138
21NEK91.79168980
22ERBB41.76814248
23PIK3CA1.68169732
24PIK3CG1.65742688
25PTK61.62695709
26FGFR31.48387386
27TIE11.46736094
28SMG11.46388082
29MAP3K31.46249492
30IRAK31.44622310
31MAPK151.39772734
32FGFR21.33780620
33MAP2K31.32817236
34TRIB31.30362030
35ABL21.28929779
36TYRO31.28479075
37TGFBR21.27988940
38MAPK111.25756733
39MUSK1.25478589
40EPHA41.25057062
41MYLK1.23755835
42MST1R1.23423165
43PINK11.18678222
44PTK21.16305837
45TYK21.10662158
46EPHB21.10217216
47PKN21.07551960
48MAP2K21.04244158
49TLK11.03926175
50MAP3K91.02001281
51MAP3K141.00164919
52PDPK11.00019314
53MAP3K20.99299194
54NME10.96090991
55PRKAA20.94889285
56RIPK10.94734133
57DYRK1B0.90122643
58SGK20.89770937
59SGK30.89450480
60STK240.88162865
61ARAF0.84033936
62EEF2K0.82395826
63PRKCI0.80212830
64ZAK0.77026485
65CDK60.76512266
66SGK4940.74663581
67SGK2230.74663581
68EPHB10.73575614
69JAK20.73455177
70MARK20.72270151
71NLK0.72117893
72TBK10.71893869
73STK390.69875775
74MAP3K120.69498397
75EPHA30.68310214
76GSK3A0.68015074
77PDK20.66145928
78NTRK10.65011015
79STK380.64266299
80SIK20.63775580
81PRKAA10.62806962
82MAP3K60.62563875
83DDR20.61808888
84JAK10.61792770
85KIT0.60473705
86NME20.60128898
87ILK0.59874985
88ERBB20.59734142
89CAMK2G0.59217363
90FGFR10.58801295
91PAK40.58445609
92GRK10.58295115
93VRK20.57918742
94PDGFRA0.56418147
95TTN0.56010183
96MAPKAPK30.55622471
97STK30.55238277
98MATK0.55205384
99MAP2K40.54966383
100CHUK0.53953732
101ACVR1B0.53374607
102NEK10.52984750
103MAP3K10.52410192
104MET0.52175328
105LATS20.50883673
106MAP3K70.50633609
107MAP2K10.49091594
108RET0.48276758
109EIF2AK30.48238322
110TGFBR10.48148021
111FER0.47087366
112BTK0.46992677
113BMX0.46940817
114SIK30.46877013
115BRSK20.45482470
116RPS6KA20.45446180
117MAP3K110.45408006
118LRRK20.43820213
119STK160.43137188
120IKBKE0.41994873
121MAP2K60.41300094
122NUAK10.39949338
123DYRK30.39546817
124CDK80.38683112
125AKT20.38367700
126TAOK20.38184968
127CAMK2D0.38184890
128PRKCZ0.38120839
129PLK40.38081803
130CDK40.37445132
131MTOR0.36666920
132PRKG20.36662186
133DMPK0.36533862
134TESK10.36023066
135MAPK40.35539493
136CDC42BPA0.35255077
137RPS6KB20.35179266
138SGK10.34681168
139RPS6KA60.34005715
140BRSK10.33981417
141PDK30.33649746
142PDK40.33649746
143BRAF0.33571043
144PRKACG0.32384689
145EIF2AK20.32282197
146PDK10.32154751
147CSNK1A10.32138929
148CSNK1E0.31570057
149RPS6KC10.31071278
150PIM10.30725603
151SCYL20.30416600
152OBSCN0.28588255
153IKBKB0.27937799

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.78701997
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.53091417
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.92352826
4Nitrogen metabolism_Homo sapiens_hsa009102.90207065
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.79580931
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.67537976
7Tryptophan metabolism_Homo sapiens_hsa003802.62324636
8Arginine biosynthesis_Homo sapiens_hsa002202.58661629
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.53380917
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.53293423
11Fatty acid degradation_Homo sapiens_hsa000712.52750208
12Complement and coagulation cascades_Homo sapiens_hsa046102.33537194
13Peroxisome_Homo sapiens_hsa041462.31980619
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.24342901
15Butanoate metabolism_Homo sapiens_hsa006502.19212572
16Propanoate metabolism_Homo sapiens_hsa006402.15951618
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.02390264
18beta-Alanine metabolism_Homo sapiens_hsa004101.97005378
19Selenocompound metabolism_Homo sapiens_hsa004501.94723056
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.81740862
21Drug metabolism - other enzymes_Homo sapiens_hsa009831.81474791
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.81241858
23Histidine metabolism_Homo sapiens_hsa003401.80267649
24Chemical carcinogenesis_Homo sapiens_hsa052041.79270108
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.77485905
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.75973610
27PPAR signaling pathway_Homo sapiens_hsa033201.70773801
28Retinol metabolism_Homo sapiens_hsa008301.69217865
29Fatty acid metabolism_Homo sapiens_hsa012121.68581275
30Sulfur metabolism_Homo sapiens_hsa009201.58033245
31Folate biosynthesis_Homo sapiens_hsa007901.56359407
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.51998414
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.51747107
34Vitamin digestion and absorption_Homo sapiens_hsa049771.49741626
35Bile secretion_Homo sapiens_hsa049761.49584016
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.49455458
37Caffeine metabolism_Homo sapiens_hsa002321.48483233
38Starch and sucrose metabolism_Homo sapiens_hsa005001.45588192
39Phenylalanine metabolism_Homo sapiens_hsa003601.44280386
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43895137
41Pyruvate metabolism_Homo sapiens_hsa006201.39674195
42Staphylococcus aureus infection_Homo sapiens_hsa051501.35651104
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33906597
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.30092963
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25714751
46Carbon metabolism_Homo sapiens_hsa012001.23647244
47ABC transporters_Homo sapiens_hsa020101.21169979
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19364475
49Tyrosine metabolism_Homo sapiens_hsa003501.17996764
50Biosynthesis of amino acids_Homo sapiens_hsa012301.17414017
51Arginine and proline metabolism_Homo sapiens_hsa003301.15688365
52Glutathione metabolism_Homo sapiens_hsa004801.06470607
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02150712
54Fat digestion and absorption_Homo sapiens_hsa049750.97092793
55Fatty acid elongation_Homo sapiens_hsa000620.94470311
56Sulfur relay system_Homo sapiens_hsa041220.91702783
57Lysine degradation_Homo sapiens_hsa003100.91376944
58One carbon pool by folate_Homo sapiens_hsa006700.89759183
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88648817
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88521665
61Steroid biosynthesis_Homo sapiens_hsa001000.80870349
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77319113
63Pentose phosphate pathway_Homo sapiens_hsa000300.74298123
64Glycerolipid metabolism_Homo sapiens_hsa005610.72319231
65Vitamin B6 metabolism_Homo sapiens_hsa007500.68946260
66Sphingolipid metabolism_Homo sapiens_hsa006000.57718904
67Metabolic pathways_Homo sapiens_hsa011000.52105470
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44825123
69Galactose metabolism_Homo sapiens_hsa000520.44134214
70Fructose and mannose metabolism_Homo sapiens_hsa000510.42047188
71Tight junction_Homo sapiens_hsa045300.39561148
72Other glycan degradation_Homo sapiens_hsa005110.34011888
73Insulin resistance_Homo sapiens_hsa049310.30870959
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27230103
75Protein digestion and absorption_Homo sapiens_hsa049740.24005215
76Prion diseases_Homo sapiens_hsa050200.20016148
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19820148
78Basal cell carcinoma_Homo sapiens_hsa052170.19565966
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19539102
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19206157
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18992121
82Arachidonic acid metabolism_Homo sapiens_hsa005900.18922749
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.15747766
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.15478144
85Linoleic acid metabolism_Homo sapiens_hsa005910.14648556
86Insulin signaling pathway_Homo sapiens_hsa049100.12904092
87Lysosome_Homo sapiens_hsa041420.12677431
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.11960964
89Thyroid hormone synthesis_Homo sapiens_hsa049180.11537157
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.10931267
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.10569617
92Fatty acid biosynthesis_Homo sapiens_hsa000610.10200334
93AMPK signaling pathway_Homo sapiens_hsa041520.09187965
94Renin-angiotensin system_Homo sapiens_hsa046140.09007100
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.08236373
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.07667284
97Mineral absorption_Homo sapiens_hsa049780.07566707
98Glucagon signaling pathway_Homo sapiens_hsa049220.05369501
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.04583564
100Regulation of autophagy_Homo sapiens_hsa041400.03179571
101Circadian rhythm_Homo sapiens_hsa04710-0.1471935
102Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1357941
103Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1317351
104ECM-receptor interaction_Homo sapiens_hsa04512-0.1302161
105Amoebiasis_Homo sapiens_hsa05146-0.1299994
106Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1242160
107Hepatitis C_Homo sapiens_hsa05160-0.1236022
108Pyrimidine metabolism_Homo sapiens_hsa00240-0.1104053
109Protein export_Homo sapiens_hsa03060-0.0857283
110N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0595939

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