GPRC5B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The encoded protein may modulate insulin secretion and increased protein expression is associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.53973102
2locomotory exploration behavior (GO:0035641)5.35654244
3postsynaptic membrane organization (GO:0001941)5.16732131
4sodium ion export (GO:0071436)4.97169998
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.91234497
6cellular potassium ion homeostasis (GO:0030007)4.90750467
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.72601794
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.52462289
9neuronal action potential propagation (GO:0019227)4.51890280
10glycine transport (GO:0015816)4.50398745
11L-amino acid import (GO:0043092)4.38660041
12gamma-aminobutyric acid transport (GO:0015812)4.26358474
13presynaptic membrane organization (GO:0097090)4.23918301
14presynaptic membrane assembly (GO:0097105)4.23263063
15synaptic vesicle exocytosis (GO:0016079)4.19367659
16central nervous system myelination (GO:0022010)4.18019664
17axon ensheathment in central nervous system (GO:0032291)4.18019664
18glutamate secretion (GO:0014047)4.15953182
19vocalization behavior (GO:0071625)4.11001078
20regulation of synaptic vesicle exocytosis (GO:2000300)4.09951214
21potassium ion import (GO:0010107)4.07187314
22layer formation in cerebral cortex (GO:0021819)4.02032249
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.99647305
24ionotropic glutamate receptor signaling pathway (GO:0035235)3.90414427
25synaptic vesicle docking involved in exocytosis (GO:0016081)3.89736960
26neurotransmitter secretion (GO:0007269)3.89176829
27membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.85734983
28regulation of synapse structural plasticity (GO:0051823)3.81526723
29regulation of neuronal synaptic plasticity (GO:0048168)3.80008558
30cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.77100849
31potassium ion homeostasis (GO:0055075)3.74049455
32regulation of glutamate receptor signaling pathway (GO:1900449)3.70256591
33regulation of long-term neuronal synaptic plasticity (GO:0048169)3.66156324
34regulation of synaptic vesicle transport (GO:1902803)3.61940050
35neuromuscular process controlling posture (GO:0050884)3.61366706
36exploration behavior (GO:0035640)3.60987392
37neuromuscular process controlling balance (GO:0050885)3.60741244
38amino acid import (GO:0043090)3.59132355
39cell communication by electrical coupling (GO:0010644)3.57384238
40cerebellar granule cell differentiation (GO:0021707)3.51449226
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.50443687
42positive regulation of dendritic spine development (GO:0060999)3.47149513
43cellular sodium ion homeostasis (GO:0006883)3.45449250
44positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.43232753
45glutamate receptor signaling pathway (GO:0007215)3.42338889
46long-term memory (GO:0007616)3.42104373
47synaptic transmission, glutamatergic (GO:0035249)3.40951178
48cerebellar Purkinje cell differentiation (GO:0021702)3.39346769
49dendritic spine morphogenesis (GO:0060997)3.37604108
50activation of protein kinase A activity (GO:0034199)3.31420620
51proline transport (GO:0015824)3.29608219
52neurotransmitter transport (GO:0006836)3.27206759
53positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.23337525
54neuron-neuron synaptic transmission (GO:0007270)3.19755651
55protein localization to synapse (GO:0035418)3.18711176
56regulation of synapse maturation (GO:0090128)3.17589544
57negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.15622056
58transmission of nerve impulse (GO:0019226)3.13909938
59dendrite morphogenesis (GO:0048813)3.13706634
60neurotransmitter-gated ion channel clustering (GO:0072578)3.12971858
61astrocyte development (GO:0014002)3.11137061
62cell communication involved in cardiac conduction (GO:0086065)3.09237187
63adult walking behavior (GO:0007628)3.06399081
64establishment of nucleus localization (GO:0040023)3.05786451
65neuronal ion channel clustering (GO:0045161)3.05371561
66cytoskeletal anchoring at plasma membrane (GO:0007016)3.05235873
67regulation of neurotransmitter levels (GO:0001505)3.04518724
68auditory behavior (GO:0031223)3.04216982
69regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.03576211
70response to auditory stimulus (GO:0010996)3.03531872
71astrocyte differentiation (GO:0048708)3.03198693
72regulation of excitatory postsynaptic membrane potential (GO:0060079)3.00956582
73mating behavior (GO:0007617)2.99756090
74positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.99692103
75axon ensheathment (GO:0008366)2.99129502
76positive regulation of potassium ion transmembrane transport (GO:1901381)2.98530258
77regulation of ARF protein signal transduction (GO:0032012)2.97635937
78positive regulation of potassium ion transport (GO:0043268)2.94548940
79regulation of synaptic plasticity (GO:0048167)2.93142639
80neuron cell-cell adhesion (GO:0007158)2.93100178
81establishment of mitochondrion localization (GO:0051654)2.93055767
82regulation of dendritic spine development (GO:0060998)2.92391713
83prepulse inhibition (GO:0060134)2.90832993
84C4-dicarboxylate transport (GO:0015740)2.90415733
85regulation of dendritic spine morphogenesis (GO:0061001)2.90314188
86positive regulation of membrane potential (GO:0045838)2.88406577
87regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.87196910
88negative regulation of dendrite morphogenesis (GO:0050774)2.85360518
89neuromuscular synaptic transmission (GO:0007274)2.85170031
90regulation of synaptic transmission (GO:0050804)2.84777681
91regulation of vesicle fusion (GO:0031338)2.84713094
92membrane hyperpolarization (GO:0060081)2.84177356
93synaptic vesicle endocytosis (GO:0048488)2.83867123
94regulation of postsynaptic membrane potential (GO:0060078)2.83776222
95substantia nigra development (GO:0021762)2.83471768
96membrane depolarization during action potential (GO:0086010)2.82565286
97G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.81286959
98regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.80335523
99membrane repolarization (GO:0086009)2.80038308
100neuromuscular process (GO:0050905)2.79975740
101negative regulation of synaptic transmission, GABAergic (GO:0032229)2.79470661
102positive regulation of dendrite development (GO:1900006)2.76637514
103regulation of synaptic transmission, glutamatergic (GO:0051966)2.76496973
104acidic amino acid transport (GO:0015800)2.75389815
105long-term synaptic potentiation (GO:0060291)2.75191745
106positive regulation of synapse maturation (GO:0090129)2.74836769
107cerebellar Purkinje cell layer development (GO:0021680)2.74065839
108regulation of voltage-gated calcium channel activity (GO:1901385)2.73633345
109regulation of neurotransmitter secretion (GO:0046928)2.73185845
110gamma-aminobutyric acid signaling pathway (GO:0007214)2.69493873
111cell differentiation in hindbrain (GO:0021533)2.67694350
112regulation of neurotransmitter transport (GO:0051588)2.67535195
113vesicle transport along microtubule (GO:0047496)2.67394433
114neurotransmitter uptake (GO:0001504)2.67305668
115L-glutamate transport (GO:0015813)2.67271205
116regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.64067853
117myelination (GO:0042552)2.62978901
118membrane depolarization (GO:0051899)2.62655987
119ensheathment of neurons (GO:0007272)2.61298628

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.51870401
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00040043
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.81733606
4* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72782463
5* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72782463
6DROSHA_22980978_ChIP-Seq_HELA_Human2.69982484
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.65398569
8* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51219858
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44662001
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.44604314
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40593924
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40560267
13* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33675607
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.31899047
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.29520461
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.24174523
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.22467121
18GBX2_23144817_ChIP-Seq_PC3_Human2.19104486
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.17461353
20* REST_21632747_ChIP-Seq_MESCs_Mouse2.13364059
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13312722
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.12346072
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.11297158
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.09255511
25RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.87975738
26ERG_21242973_ChIP-ChIP_JURKAT_Human1.86796405
27* REST_18959480_ChIP-ChIP_MESCs_Mouse1.84502686
28AR_21572438_ChIP-Seq_LNCaP_Human1.80706386
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67226973
30WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.53588861
31* KDM2B_26808549_Chip-Seq_K562_Human1.53327177
32DNAJC2_21179169_ChIP-ChIP_NT2_Human1.48439075
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47910337
34* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45128959
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44600167
36WT1_25993318_ChIP-Seq_PODOCYTE_Human1.43197343
37* RING1B_27294783_Chip-Seq_ESCs_Mouse1.35185775
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32299190
39* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30539380
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29295741
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27307658
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26433655
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26324006
44GATA1_26923725_Chip-Seq_HPCs_Mouse1.24980380
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23817833
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.22747176
47ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22668514
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20130368
49* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16970000
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16555424
51AR_19668381_ChIP-Seq_PC3_Human1.15760585
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14040478
53* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13442503
54GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13419314
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12079323
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11903022
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11588181
58SMAD4_21799915_ChIP-Seq_A2780_Human1.11556978
59EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10629714
60* RING1B_27294783_Chip-Seq_NPCs_Mouse1.10587712
61TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09783037
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09634620
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.09030302
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07480565
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07337791
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07191449
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07100394
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05686960
69EP300_21415370_ChIP-Seq_HL-1_Mouse1.05283690
70ESR1_20079471_ChIP-ChIP_T-47D_Human1.03213660
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03044856
72TET1_21490601_ChIP-Seq_MESCs_Mouse1.00696426
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00079816
74ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99611064
75CBX2_27304074_Chip-Seq_ESCs_Mouse0.99444020
76* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98734378
77AHR_22903824_ChIP-Seq_MCF-7_Human0.98713329
78ARNT_22903824_ChIP-Seq_MCF-7_Human0.97745076
79SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97033204
80DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96651294
81STAT3_23295773_ChIP-Seq_U87_Human0.96516256
82RXR_22108803_ChIP-Seq_LS180_Human0.96360401
83ZNF274_21170338_ChIP-Seq_K562_Hela0.95728432
84RNF2_27304074_Chip-Seq_NSC_Mouse0.95390488
85CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95373066
86SMAD4_21741376_ChIP-Seq_HESCs_Human0.93241352
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92862561
88* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92808095
89KLF4_19829295_ChIP-Seq_ESCs_Human0.92799849
90CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92521081
91OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91424777
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89898516
93TP53_16413492_ChIP-PET_HCT116_Human0.89564523
94SMAD3_21741376_ChIP-Seq_HESCs_Human0.89510214
95YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89070980
96SMAD3_21741376_ChIP-Seq_ESCs_Human0.89038619
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88983187
98KDM2B_26808549_Chip-Seq_JURKAT_Human0.88238834
99SMAD3_21741376_ChIP-Seq_EPCs_Human0.88149672
100AR_25329375_ChIP-Seq_VCAP_Human0.88060285
101CTCF_27219007_Chip-Seq_Bcells_Human0.87758266
102CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87528034
103TRIM28_21343339_ChIP-Seq_HEK293_Human0.86249786
104PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86208865
105CTBP1_25329375_ChIP-Seq_LNCAP_Human0.86173387
106SMAD_19615063_ChIP-ChIP_OVARY_Human0.85184921
107NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84929497
108DPY_21335234_ChIP-Seq_ESCs_Mouse0.84772534
109TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84468938
110KDM2B_26808549_Chip-Seq_DND41_Human0.83873489
111RUNX1_26923725_Chip-Seq_HPCs_Mouse0.83623435
112TP53_20018659_ChIP-ChIP_R1E_Mouse0.83521549
113LXR_22292898_ChIP-Seq_THP-1_Human0.83216408
114SOX9_26525672_Chip-Seq_HEART_Mouse0.82844319
115NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.82312835
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81657415
117P53_22127205_ChIP-Seq_FIBROBLAST_Human0.80749980
118STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.80248121
119POU5F1_16518401_ChIP-PET_MESCs_Mouse0.79915408
120ISL1_27105846_Chip-Seq_CPCs_Mouse0.78690446

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.99468689
2MP0003635_abnormal_synaptic_transmissio3.73122217
3MP0003880_abnormal_central_pattern3.69184369
4MP0004270_analgesia3.33769868
5MP0009046_muscle_twitch3.18911031
6MP0002064_seizures2.99609992
7MP0009745_abnormal_behavioral_response2.94667300
8MP0002063_abnormal_learning/memory/cond2.71697852
9MP0002272_abnormal_nervous_system2.67592655
10MP0005423_abnormal_somatic_nervous2.63917226
11MP0001486_abnormal_startle_reflex2.58386278
12MP0008569_lethality_at_weaning2.52753651
13MP0004885_abnormal_endolymph2.52213015
14MP0003690_abnormal_glial_cell2.33827645
15MP0003329_amyloid_beta_deposits2.33689035
16MP0002734_abnormal_mechanical_nocicepti2.26433818
17MP0002572_abnormal_emotion/affect_behav2.25828936
18MP0004858_abnormal_nervous_system2.18664036
19MP0000920_abnormal_myelination2.13282306
20MP0001968_abnormal_touch/_nociception2.12838412
21MP0002822_catalepsy2.04616986
22MP0001501_abnormal_sleep_pattern1.94325317
23MP0009780_abnormal_chondrocyte_physiolo1.92025199
24MP0002909_abnormal_adrenal_gland1.89421580
25MP0001440_abnormal_grooming_behavior1.86223988
26MP0002067_abnormal_sensory_capabilities1.83926045
27MP0003633_abnormal_nervous_system1.69550353
28MP0002733_abnormal_thermal_nociception1.68867135
29MP0001970_abnormal_pain_threshold1.68369343
30MP0005623_abnormal_meninges_morphology1.66127414
31MP0000955_abnormal_spinal_cord1.63644452
32MP0000751_myopathy1.62637746
33MP0004145_abnormal_muscle_electrophysio1.61323355
34MP0003634_abnormal_glial_cell1.57865623
35MP0000778_abnormal_nervous_system1.55923351
36MP0004811_abnormal_neuron_physiology1.52481477
37MP0002736_abnormal_nociception_after1.50165327
38MP0004142_abnormal_muscle_tone1.50093052
39MP0005167_abnormal_blood-brain_barrier1.47293201
40MP0003631_nervous_system_phenotype1.44827454
41MP0005386_behavior/neurological_phenoty1.41988825
42MP0004924_abnormal_behavior1.41988825
43MP0002066_abnormal_motor_capabilities/c1.41700042
44MP0000013_abnormal_adipose_tissue1.41049943
45MP0002184_abnormal_innervation1.40934882
46MP0002557_abnormal_social/conspecific_i1.37556986
47MP0002882_abnormal_neuron_morphology1.35363673
48MP0003632_abnormal_nervous_system1.32524747
49MP0006276_abnormal_autonomic_nervous1.30537693
50MP0003283_abnormal_digestive_organ1.27545831
51MP0002735_abnormal_chemical_nociception1.27138050
52MP0003879_abnormal_hair_cell1.25280570
53MP0005646_abnormal_pituitary_gland1.23855909
54MP0003075_altered_response_to1.20460280
55MP0002638_abnormal_pupillary_reflex1.17385323
56MP0001299_abnormal_eye_distance/1.13586837
57MP0001177_atelectasis1.13391492
58MP0001485_abnormal_pinna_reflex1.13086218
59MP0002229_neurodegeneration1.10504450
60MP0001502_abnormal_circadian_rhythm1.08286338
61MP0003136_yellow_coat_color1.08000657
62MP0004742_abnormal_vestibular_system1.07901675
63MP0002152_abnormal_brain_morphology1.07266084
64MP0000604_amyloidosis1.05908573
65MP0000747_muscle_weakness1.05612145
66MP0004130_abnormal_muscle_cell1.04875059
67MP0003123_paternal_imprinting1.04352072
68MP0004043_abnormal_pH_regulation1.04232950
69MP0000566_synostosis1.00810263
70MP0000579_abnormal_nail_morphology0.91263848
71MP0000003_abnormal_adipose_tissue0.90561612
72MP0002090_abnormal_vision0.89717782
73MP0003137_abnormal_impulse_conducting0.89048992
74MP0005645_abnormal_hypothalamus_physiol0.88432095
75MP0004233_abnormal_muscle_weight0.88170714
76MP0008961_abnormal_basal_metabolism0.87389877
77MP0004215_abnormal_myocardial_fiber0.83137807
78MP0003045_fibrosis0.82866169
79MP0001905_abnormal_dopamine_level0.81008475
80MP0002069_abnormal_eating/drinking_beha0.78503928
81MP0001963_abnormal_hearing_physiology0.78069341
82MP0004085_abnormal_heartbeat0.77247903
83MP0001346_abnormal_lacrimal_gland0.77203543
84MP0008872_abnormal_physiological_respon0.77185547
85MP0008874_decreased_physiological_sensi0.76854152
86MP0005171_absent_coat_pigmentation0.76676980
87MP0001984_abnormal_olfaction0.74483785
88MP0003122_maternal_imprinting0.73479304
89MP0002089_abnormal_postnatal_growth/wei0.71963620
90MP0000026_abnormal_inner_ear0.70817480
91MP0003861_abnormal_nervous_system0.70460178
92MP0005551_abnormal_eye_electrophysiolog0.68430956
93MP0004147_increased_porphyrin_level0.68379381
94MP0003787_abnormal_imprinting0.68261554
95MP0005535_abnormal_body_temperature0.67486740
96MP0001529_abnormal_vocalization0.64971633
97MP0002752_abnormal_somatic_nervous0.64696810
98MP0003172_abnormal_lysosome_physiology0.61472576
99MP0004087_abnormal_muscle_fiber0.61093521
100MP0005375_adipose_tissue_phenotype0.60838160
101MP0001943_abnormal_respiration0.60795504
102MP0004484_altered_response_of0.60065000
103MP0003938_abnormal_ear_development0.59243693
104MP0000749_muscle_degeneration0.59229668
105MP0001958_emphysema0.58468569
106MP0004036_abnormal_muscle_relaxation0.58272059
107MP0010768_mortality/aging0.56530714
108MP0002249_abnormal_larynx_morphology0.56521394
109MP0002653_abnormal_ependyma_morphology0.56447345
110MP0000639_abnormal_adrenal_gland0.55910180
111MP0010770_preweaning_lethality0.55405690
112MP0002082_postnatal_lethality0.55405690
113MP0002108_abnormal_muscle_morphology0.53922274
114MP0005620_abnormal_muscle_contractility0.51630401
115MP0010769_abnormal_survival0.51583585
116MP0009672_abnormal_birth_weight0.51503334
117MP0001188_hyperpigmentation0.49000546

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.80973176
2Focal motor seizures (HP:0011153)5.14492755
3Action tremor (HP:0002345)5.11512481
4Focal seizures (HP:0007359)4.21244991
5Supranuclear gaze palsy (HP:0000605)4.15539394
6Visual hallucinations (HP:0002367)3.98458996
7Progressive cerebellar ataxia (HP:0002073)3.75314715
8Ankle clonus (HP:0011448)3.65277053
9Intention tremor (HP:0002080)3.54580927
10Neurofibrillary tangles (HP:0002185)3.52162051
11Megalencephaly (HP:0001355)3.40566228
12Dysdiadochokinesis (HP:0002075)3.39249825
13Hemiplegia (HP:0002301)3.32614310
14Dysmetria (HP:0001310)3.26592338
15Obstructive sleep apnea (HP:0002870)3.25608909
16Atonic seizures (HP:0010819)3.19176227
17Cerebral hypomyelination (HP:0006808)3.03963697
18Postural instability (HP:0002172)3.00698449
19Depression (HP:0000716)2.99556762
20Cerebral inclusion bodies (HP:0100314)2.96358192
21Scanning speech (HP:0002168)2.95523610
22Epileptic encephalopathy (HP:0200134)2.92251319
23Generalized tonic-clonic seizures (HP:0002069)2.83193566
24Aplasia involving bones of the extremities (HP:0009825)2.82474878
25Aplasia involving bones of the upper limbs (HP:0009823)2.82474878
26Aplasia of the phalanges of the hand (HP:0009802)2.82474878
27Gaze-evoked nystagmus (HP:0000640)2.82041909
28Split foot (HP:0001839)2.81680579
29Abnormal eating behavior (HP:0100738)2.78145074
30Peripheral hypomyelination (HP:0007182)2.78031761
31Limb dystonia (HP:0002451)2.73591153
32Hemiparesis (HP:0001269)2.72634129
33Absence seizures (HP:0002121)2.71468127
34Truncal ataxia (HP:0002078)2.71381215
35Termporal pattern (HP:0011008)2.68427151
36Insidious onset (HP:0003587)2.68427151
37Abnormality of the lower motor neuron (HP:0002366)2.61554603
38Ventricular fibrillation (HP:0001663)2.60700559
39Spastic gait (HP:0002064)2.57189428
40Urinary urgency (HP:0000012)2.57136527
41Sleep apnea (HP:0010535)2.56342091
42Impaired vibration sensation in the lower limbs (HP:0002166)2.54459866
43Anxiety (HP:0000739)2.53760802
44Torticollis (HP:0000473)2.51910288
45Febrile seizures (HP:0002373)2.51739261
46Dialeptic seizures (HP:0011146)2.50712310
47Poor eye contact (HP:0000817)2.50455359
48Urinary bladder sphincter dysfunction (HP:0002839)2.49234831
49Abnormality of binocular vision (HP:0011514)2.48910021
50Diplopia (HP:0000651)2.48910021
51Akinesia (HP:0002304)2.48671064
52Annular pancreas (HP:0001734)2.48017836
53Insomnia (HP:0100785)2.45530096
54Dysmetric saccades (HP:0000641)2.44309185
55Bundle branch block (HP:0011710)2.41497119
56Impaired social interactions (HP:0000735)2.40890461
57Abnormal social behavior (HP:0012433)2.40890461
58Genetic anticipation (HP:0003743)2.40451538
59Broad-based gait (HP:0002136)2.39067996
60Postural tremor (HP:0002174)2.35674520
61Onion bulb formation (HP:0003383)2.31288214
62Lower limb muscle weakness (HP:0007340)2.27870561
63Abnormality of the corticospinal tract (HP:0002492)2.27618825
64Broad metatarsal (HP:0001783)2.24284974
65Mutism (HP:0002300)2.22770749
66Impaired smooth pursuit (HP:0007772)2.22058158
67Increased circulating renin level (HP:0000848)2.19980760
68Focal dystonia (HP:0004373)2.18765715
69Abnormality of saccadic eye movements (HP:0000570)2.17942913
70Neuronal loss in central nervous system (HP:0002529)2.17051829
71Difficulty running (HP:0009046)2.15777697
72Hyporeflexia of lower limbs (HP:0002600)2.12601333
73Pointed chin (HP:0000307)2.08384926
74Clonus (HP:0002169)2.07263554
75Abnormality of ocular smooth pursuit (HP:0000617)2.07236970
76Epileptiform EEG discharges (HP:0011182)2.06920824
77Pheochromocytoma (HP:0002666)2.05325939
78Morphological abnormality of the inner ear (HP:0011390)2.05320210
79Choreoathetosis (HP:0001266)2.01673257
80Tetraplegia (HP:0002445)2.00884636
81Turricephaly (HP:0000262)2.00043881
82Papilledema (HP:0001085)1.99634625
83Apathy (HP:0000741)1.99039716
84Craniofacial dystonia (HP:0012179)1.98854293
85Bronchomalacia (HP:0002780)1.97627507
86Alacrima (HP:0000522)1.96947874
87Rapidly progressive (HP:0003678)1.96170557
88Slow progression (HP:0003677)1.95289851
89Upper limb amyotrophy (HP:0009129)1.94351323
90Distal upper limb amyotrophy (HP:0007149)1.94351323
91Bradykinesia (HP:0002067)1.93869055
92Muscle fiber splitting (HP:0003555)1.90633937
93Gait ataxia (HP:0002066)1.90392297
94Foot dorsiflexor weakness (HP:0009027)1.90178628
95Rigidity (HP:0002063)1.89944301
96Delusions (HP:0000746)1.89779392
97Polyphagia (HP:0002591)1.89293315
98Overriding aorta (HP:0002623)1.88982487
99Shallow orbits (HP:0000586)1.88796471
100CNS hypomyelination (HP:0003429)1.88595365
101Amblyopia (HP:0000646)1.88139423
102Degeneration of the lateral corticospinal tracts (HP:0002314)1.87989925
103Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.87989925
104Exercise-induced myalgia (HP:0003738)1.87729833
105Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.87235357
106Hammertoe (HP:0001765)1.86994667
107Increased variability in muscle fiber diameter (HP:0003557)1.86987310
108Heart block (HP:0012722)1.85835947
109Lower limb amyotrophy (HP:0007210)1.85800316
110Exercise-induced muscle cramps (HP:0003710)1.85433376
111Fetal akinesia sequence (HP:0001989)1.85386089
112Neoplasm of the heart (HP:0100544)1.84625561
113Spastic tetraparesis (HP:0001285)1.84165804
114Abnormality of the foot musculature (HP:0001436)1.83929810
115Morphological abnormality of the pyramidal tract (HP:0002062)1.83620844
116Status epilepticus (HP:0002133)1.83363289
117Clumsiness (HP:0002312)1.82839887
118EEG with generalized epileptiform discharges (HP:0011198)1.81338204
119Abnormality of the periventricular white matter (HP:0002518)1.79893808
120Stereotypic behavior (HP:0000733)1.77899813
121Impaired vibratory sensation (HP:0002495)1.77449854
122Nuclear cataract (HP:0100018)1.76960199
123Diminished motivation (HP:0000745)1.75181964
124Prolonged QT interval (HP:0001657)1.73435543
125Humeroradial synostosis (HP:0003041)1.73326778
126Synostosis involving the elbow (HP:0003938)1.73326778
127Resting tremor (HP:0002322)1.72386752

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.32370282
2MAP3K93.26740761
3EPHA43.07551384
4PRKD32.88898140
5PAK62.59307533
6KSR22.21689548
7CASK2.15736735
8NTRK12.10053244
9CAMKK12.09973977
10MAP3K42.07852126
11NTRK22.07075243
12MINK12.06877983
13DAPK21.87331329
14TYRO31.87223052
15LMTK21.83822303
16WNK11.83435827
17STK381.80053752
18RIPK11.75168566
19MARK11.70812776
20PHKG21.60648584
21PHKG11.60648584
22CDK191.54066800
23TRIB31.53717935
24UHMK11.47498123
25CDK51.42306450
26STK391.39253561
27PRPF4B1.38254075
28OXSR11.37009670
29PINK11.35698781
30CAMKK21.34845817
31MAP2K41.33598283
32PRKCH1.32602163
33SGK4941.30673166
34SGK2231.30673166
35CAMK1G1.28346666
36DDR21.19635794
37MAP2K71.18757823
38MAP3K21.14974956
39FGFR21.10590448
40DYRK1A1.03741379
41KSR11.01031392
42ALK1.01018737
43ROCK21.00835104
44RET0.99660875
45CDK150.95029371
46STK110.94843708
47BMX0.92761736
48ICK0.92166814
49CAMK2B0.91663044
50MAP3K130.91425109
51PNCK0.91086346
52CDK140.90946911
53PRKCG0.89883734
54CDK180.89841849
55PDGFRA0.89790444
56CAMK10.89371144
57GRK50.88260167
58MAPK120.87804883
59MAPKAPK50.86529411
60TNIK0.86251472
61EPHB10.85692599
62PDPK10.84968539
63PAK30.84695129
64SGK30.82616467
65CDK11A0.82438486
66TIE10.81906913
67ARAF0.81506784
68NEK60.81158429
69RIPK40.80379748
70CAMK2G0.79231437
71FES0.79134878
72CAMK1D0.78772507
73DMPK0.77341704
74MARK20.76747958
75PDK10.76079544
76CDC42BPA0.74671407
77CAMK2A0.74486428
78LATS20.74432922
79CAMK2D0.73648791
80WNK40.70803096
81TAOK10.66762967
82TNK20.66491808
83SGK10.64308694
84PRKD10.63555903
85PLK20.63034714
86LIMK10.62026195
87PTK2B0.61824804
88MAP3K70.59388844
89SIK20.58269974
90MAP3K10.57990484
91SGK20.57161723
92PKN10.56902408
93MAPK130.56652519
94MAPK100.55971649
95RPS6KA30.55903037
96FER0.53780731
97CSNK1G20.53721567
98FYN0.53208354
99BRSK10.52846830
100SIK10.52625998
101OBSCN0.52423588
102ROCK10.51618566
103ERBB20.49519063
104DAPK30.49448574
105MAP3K120.49215232
106CAMK40.48732583
107PRKG10.47544666
108DAPK10.45524804
109BRAF0.43222932
110PRKCZ0.42369909
111PTK20.34289535
112PRKG20.34225647
113CSNK1D0.34107969
114PRKDC0.32390175
115RAF10.31542510
116CSNK1A10.31453611
117TESK10.31289519
118SRC0.30833373
119GSK3B0.30578388

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.31041302
2Nicotine addiction_Homo sapiens_hsa050332.71261763
3Synaptic vesicle cycle_Homo sapiens_hsa047212.50839153
4GABAergic synapse_Homo sapiens_hsa047272.44183651
5Glutamatergic synapse_Homo sapiens_hsa047242.30023228
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.25533248
7Circadian entrainment_Homo sapiens_hsa047132.25455693
8Long-term potentiation_Homo sapiens_hsa047202.11713284
9Olfactory transduction_Homo sapiens_hsa047402.11055452
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.05794039
11Salivary secretion_Homo sapiens_hsa049702.05389886
12Morphine addiction_Homo sapiens_hsa050322.02728166
13Gastric acid secretion_Homo sapiens_hsa049712.01736154
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.01164395
15Amphetamine addiction_Homo sapiens_hsa050311.77966570
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.72333781
17Insulin secretion_Homo sapiens_hsa049111.68127829
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66295302
19Dopaminergic synapse_Homo sapiens_hsa047281.64434695
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.57532273
21Long-term depression_Homo sapiens_hsa047301.57421338
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.56339844
23Cholinergic synapse_Homo sapiens_hsa047251.54288346
24Renin secretion_Homo sapiens_hsa049241.47194843
25Vitamin B6 metabolism_Homo sapiens_hsa007501.44632583
26Fatty acid biosynthesis_Homo sapiens_hsa000611.43450256
27Oxytocin signaling pathway_Homo sapiens_hsa049211.39796760
28Cocaine addiction_Homo sapiens_hsa050301.38939334
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.35372735
30Taste transduction_Homo sapiens_hsa047421.28496565
31cAMP signaling pathway_Homo sapiens_hsa040241.28336836
32Gap junction_Homo sapiens_hsa045401.28324910
33GnRH signaling pathway_Homo sapiens_hsa049121.27128670
34Calcium signaling pathway_Homo sapiens_hsa040201.26297619
35Arginine and proline metabolism_Homo sapiens_hsa003301.13204346
36Histidine metabolism_Homo sapiens_hsa003401.12757453
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12081401
38Estrogen signaling pathway_Homo sapiens_hsa049151.10434464
39Dorso-ventral axis formation_Homo sapiens_hsa043201.09426707
40Type II diabetes mellitus_Homo sapiens_hsa049301.08880222
41Serotonergic synapse_Homo sapiens_hsa047261.07533434
42Phospholipase D signaling pathway_Homo sapiens_hsa040721.07285794
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03969451
44Glioma_Homo sapiens_hsa052141.02733610
45Dilated cardiomyopathy_Homo sapiens_hsa054141.01557250
46Axon guidance_Homo sapiens_hsa043601.00780230
47Melanogenesis_Homo sapiens_hsa049160.98335315
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98237451
49Pancreatic secretion_Homo sapiens_hsa049720.98130204
50ErbB signaling pathway_Homo sapiens_hsa040120.91836489
51beta-Alanine metabolism_Homo sapiens_hsa004100.88263982
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.87963642
53Bile secretion_Homo sapiens_hsa049760.87851466
54Thyroid hormone synthesis_Homo sapiens_hsa049180.87667666
55Cardiac muscle contraction_Homo sapiens_hsa042600.85797760
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85434300
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81972592
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77271274
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76004692
60Endocytosis_Homo sapiens_hsa041440.74585909
61Circadian rhythm_Homo sapiens_hsa047100.73799768
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70468170
63Choline metabolism in cancer_Homo sapiens_hsa052310.68261081
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67885303
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67061553
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.66961894
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64071005
68Renal cell carcinoma_Homo sapiens_hsa052110.63729065
69MAPK signaling pathway_Homo sapiens_hsa040100.63645690
70Rap1 signaling pathway_Homo sapiens_hsa040150.62765135
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.62299085
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60935357
73Arginine biosynthesis_Homo sapiens_hsa002200.60213054
74Inositol phosphate metabolism_Homo sapiens_hsa005620.58776205
75Tight junction_Homo sapiens_hsa045300.58747794
76Oocyte meiosis_Homo sapiens_hsa041140.58342574
77VEGF signaling pathway_Homo sapiens_hsa043700.57568509
78Hippo signaling pathway_Homo sapiens_hsa043900.57088667
79mTOR signaling pathway_Homo sapiens_hsa041500.56174079
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56003596
81Collecting duct acid secretion_Homo sapiens_hsa049660.55856521
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55651900
83Ras signaling pathway_Homo sapiens_hsa040140.55264450
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55261557
85Ovarian steroidogenesis_Homo sapiens_hsa049130.53399144
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51005964
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50045777
88Glucagon signaling pathway_Homo sapiens_hsa049220.48468093
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47751750
90Proteoglycans in cancer_Homo sapiens_hsa052050.47162526
91Hedgehog signaling pathway_Homo sapiens_hsa043400.47140380
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46716902
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.45614470
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.45223736
95Insulin signaling pathway_Homo sapiens_hsa049100.45214838
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44941006
97Vibrio cholerae infection_Homo sapiens_hsa051100.44546132
98Mineral absorption_Homo sapiens_hsa049780.44083238
99Prion diseases_Homo sapiens_hsa050200.43900247
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42633281
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42516482
102Wnt signaling pathway_Homo sapiens_hsa043100.42426773
103Focal adhesion_Homo sapiens_hsa045100.42212040
104Non-small cell lung cancer_Homo sapiens_hsa052230.41252733
105AMPK signaling pathway_Homo sapiens_hsa041520.40551897
106Fatty acid metabolism_Homo sapiens_hsa012120.40068707
107Endometrial cancer_Homo sapiens_hsa052130.39494871
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37748743
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37738195
110Adherens junction_Homo sapiens_hsa045200.37171021
111Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35359284
112Protein digestion and absorption_Homo sapiens_hsa049740.33372418
113Phototransduction_Homo sapiens_hsa047440.32574324
114Biosynthesis of amino acids_Homo sapiens_hsa012300.30147395

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