GPR89B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.26595980
2centriole replication (GO:0007099)4.20827553
3replication fork processing (GO:0031297)4.09020661
4DNA double-strand break processing (GO:0000729)3.75745800
5ribosome assembly (GO:0042255)3.72938882
6somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.68783958
7isotype switching (GO:0045190)3.68783958
8somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.68783958
9chromatin remodeling at centromere (GO:0031055)3.68561483
10CENP-A containing nucleosome assembly (GO:0034080)3.64347675
11rRNA modification (GO:0000154)3.63446834
12peptidyl-histidine modification (GO:0018202)3.60431151
13nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.57231352
14mitochondrial respiratory chain complex I assembly (GO:0032981)3.54171469
15NADH dehydrogenase complex assembly (GO:0010257)3.54171469
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.54171469
17transcription from mitochondrial promoter (GO:0006390)3.54048638
18exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.53082395
19protein complex biogenesis (GO:0070271)3.52000056
20mitochondrial respiratory chain complex assembly (GO:0033108)3.51408699
21protein deneddylation (GO:0000338)3.45885218
22somatic diversification of immune receptors via somatic mutation (GO:0002566)3.44727365
23somatic hypermutation of immunoglobulin genes (GO:0016446)3.44727365
24DNA deamination (GO:0045006)3.41886657
25regulation of helicase activity (GO:0051095)3.38491901
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.37931769
27pseudouridine synthesis (GO:0001522)3.34180587
28mitochondrial RNA metabolic process (GO:0000959)3.33229652
29DNA replication checkpoint (GO:0000076)3.32911681
30negative regulation of DNA recombination (GO:0045910)3.32671239
31rRNA methylation (GO:0031167)3.31751937
32maturation of 5.8S rRNA (GO:0000460)3.30248915
33somatic diversification of immunoglobulins (GO:0016445)3.29485588
34somatic recombination of immunoglobulin gene segments (GO:0016447)3.21362770
35negative regulation of DNA-dependent DNA replication (GO:2000104)3.20112948
36regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.19506147
37histone exchange (GO:0043486)3.19247083
38regulation of centriole replication (GO:0046599)3.18224774
39histone H2A acetylation (GO:0043968)3.18104893
40positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.18085975
41base-excision repair, AP site formation (GO:0006285)3.16731372
42DNA replication-dependent nucleosome assembly (GO:0006335)3.13408191
43DNA replication-dependent nucleosome organization (GO:0034723)3.13408191
44respiratory chain complex IV assembly (GO:0008535)3.12490815
45cullin deneddylation (GO:0010388)3.12380055
46RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.11384881
47maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.04531069
48positive regulation of histone H3-K4 methylation (GO:0051571)3.04454463
49double-strand break repair via homologous recombination (GO:0000724)3.03669834
50recombinational repair (GO:0000725)3.02526449
51signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.98487736
52signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.98487736
53signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.98487736
54synapsis (GO:0007129)2.98187924
55negative regulation of ligase activity (GO:0051352)2.97596791
56negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.97596791
57regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.96996568
58regulation of mitotic spindle checkpoint (GO:1903504)2.96996568
59DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.96833825
60reciprocal meiotic recombination (GO:0007131)2.96562901
61reciprocal DNA recombination (GO:0035825)2.96562901
62histone mRNA metabolic process (GO:0008334)2.95709977
63intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.94446808
64signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.94446808
65anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.92891144
66protein neddylation (GO:0045116)2.87852188
67regulation of cellular amino acid metabolic process (GO:0006521)2.86829682
68chaperone-mediated protein transport (GO:0072321)2.85715118
69signal transduction involved in cell cycle checkpoint (GO:0072395)2.83255602
70L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.82712728
71signal transduction involved in DNA damage checkpoint (GO:0072422)2.81694450
72signal transduction involved in DNA integrity checkpoint (GO:0072401)2.81694450
73purine nucleobase biosynthetic process (GO:0009113)2.81526467
74somatic diversification of immune receptors (GO:0002200)2.77322220
75pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.76663771
76mitotic recombination (GO:0006312)2.74747850
77positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.74568884
78prenylation (GO:0097354)2.74562032
79protein prenylation (GO:0018342)2.74562032
80cytochrome complex assembly (GO:0017004)2.72301634
81nucleobase biosynthetic process (GO:0046112)2.72134416
82centriole assembly (GO:0098534)2.72073559
83DNA replication-independent nucleosome organization (GO:0034724)2.71308549
84DNA replication-independent nucleosome assembly (GO:0006336)2.71308549
85non-recombinational repair (GO:0000726)2.69992006
86double-strand break repair via nonhomologous end joining (GO:0006303)2.69992006
87regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.68882423
88somatic cell DNA recombination (GO:0016444)2.66918738
89somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.66918738
90mannosylation (GO:0097502)2.66153713
91kinetochore organization (GO:0051383)2.63843274
92DNA ligation (GO:0006266)2.61238225
93telomere maintenance via recombination (GO:0000722)2.60570879
94negative regulation of translational initiation (GO:0045947)2.60519463
95ubiquinone biosynthetic process (GO:0006744)2.60049921
96DNA catabolic process, exonucleolytic (GO:0000738)2.59860859
97mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.59642411
98positive regulation of ligase activity (GO:0051351)2.59028891
99regulation of DNA endoreduplication (GO:0032875)2.58795549
100kinetochore assembly (GO:0051382)2.58440035

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.41319530
2E2F7_22180533_ChIP-Seq_HELA_Human4.05392538
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.76668610
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.49730648
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.00514827
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.96378850
7ELK1_19687146_ChIP-ChIP_HELA_Human2.83702121
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.81503756
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.79947589
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.73550302
11VDR_23849224_ChIP-Seq_CD4+_Human2.69746406
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.67438882
13PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.60915324
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.60399344
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.52520110
16FOXP3_21729870_ChIP-Seq_TREG_Human2.37380819
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.35892756
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.27058866
19* PADI4_21655091_ChIP-ChIP_MCF-7_Human2.20410585
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20116227
21FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.18291302
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.04459559
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.03554063
24FUS_26573619_Chip-Seq_HEK293_Human1.89035115
25ZNF274_21170338_ChIP-Seq_K562_Hela1.88032597
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86395698
27HOXB4_20404135_ChIP-ChIP_EML_Mouse1.83696624
28EWS_26573619_Chip-Seq_HEK293_Human1.82834140
29IGF1R_20145208_ChIP-Seq_DFB_Human1.81700036
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.79209269
31KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.75638370
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.72015885
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69478028
34DCP1A_22483619_ChIP-Seq_HELA_Human1.65085864
35GABP_19822575_ChIP-Seq_HepG2_Human1.63336290
36MYC_18940864_ChIP-ChIP_HL60_Human1.62030132
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59388655
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56845185
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.56204187
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53341097
41IRF1_19129219_ChIP-ChIP_H3396_Human1.50040865
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49866700
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48057881
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46455021
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41431711
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.40714412
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.40432191
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.40313118
49KDM5A_27292631_Chip-Seq_BREAST_Human1.40271523
50ER_23166858_ChIP-Seq_MCF-7_Human1.37492124
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36164735
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32411014
53TTF2_22483619_ChIP-Seq_HELA_Human1.21777635
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.20667961
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19784443
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19482314
57TAF15_26573619_Chip-Seq_HEK293_Human1.17856313
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.17069284
59TP53_22573176_ChIP-Seq_HFKS_Human1.14934664
60P300_19829295_ChIP-Seq_ESCs_Human1.14636485
61EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14428355
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13903710
63VDR_22108803_ChIP-Seq_LS180_Human1.13154865
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12963091
65MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11157681
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09458083
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04139800
68E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04061452
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03976457
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03956767
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01507146
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00821314
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.00355563
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00355563
75EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.99405875
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99219172
77CRX_20693478_ChIP-Seq_RETINA_Mouse0.98266549
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96585485
79MYC_19079543_ChIP-ChIP_MESCs_Mouse0.95661347
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94970468
81* XRN2_22483619_ChIP-Seq_HELA_Human0.92881716
82PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92524264
83ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92413288
84MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.92381559
85FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89943540
86POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89645438
87CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89415501
88NANOG_16153702_ChIP-ChIP_HESCs_Human0.88132400
89SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.87773284
90TFEB_21752829_ChIP-Seq_HELA_Human0.86518693
91NANOG_19829295_ChIP-Seq_ESCs_Human0.86171528
92SOX2_19829295_ChIP-Seq_ESCs_Human0.86171528
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85548020
94GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.85277212
95SALL4_22934838_ChIP-ChIP_CD34+_Human0.85220961
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.84703427
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.82379283
98CIITA_25753668_ChIP-Seq_RAJI_Human0.82291306
99CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.81602063
100P300_18555785_Chip-Seq_ESCs_Mouse0.80841467

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair4.39326260
2MP0008057_abnormal_DNA_replication3.82021658
3MP0010094_abnormal_chromosome_stability3.47595675
4MP0008877_abnormal_DNA_methylation3.39433799
5MP0009697_abnormal_copulation3.24825323
6MP0004147_increased_porphyrin_level2.98604859
7MP0003786_premature_aging2.71505679
8MP0005075_abnormal_melanosome_morpholog2.60312112
9MP0003718_maternal_effect2.53101785
10MP0008007_abnormal_cellular_replicative2.39183935
11MP0003787_abnormal_imprinting2.34669361
12MP0000372_irregular_coat_pigmentation2.33827785
13MP0004957_abnormal_blastocyst_morpholog2.31313365
14MP0003111_abnormal_nucleus_morphology2.28154252
15MP0005083_abnormal_biliary_tract2.24184687
16MP0003077_abnormal_cell_cycle2.09139606
17MP0002102_abnormal_ear_morphology2.08640642
18MP0003186_abnormal_redox_activity1.91204887
19MP0003693_abnormal_embryo_hatching1.86700488
20MP0003806_abnormal_nucleotide_metabolis1.84388822
21MP0003121_genomic_imprinting1.83341742
22MP0008875_abnormal_xenobiotic_pharmacok1.76695697
23MP0003195_calcinosis1.74579847
24MP0005085_abnormal_gallbladder_physiolo1.72429510
25MP0006036_abnormal_mitochondrial_physio1.65818890
26MP0008995_early_reproductive_senescence1.62241326
27MP0006035_abnormal_mitochondrial_morpho1.61847720
28MP0008932_abnormal_embryonic_tissue1.51080724
29MP0003890_abnormal_embryonic-extraembry1.46097484
30MP0006054_spinal_hemorrhage1.42345446
31MP0004043_abnormal_pH_regulation1.39825115
32MP0002160_abnormal_reproductive_system1.38819078
33MP0001764_abnormal_homeostasis1.36524954
34MP0001929_abnormal_gametogenesis1.33462360
35MP0003252_abnormal_bile_duct1.32810240
36MP0000427_abnormal_hair_cycle1.31106177
37MP0008872_abnormal_physiological_respon1.28853401
38MP0006072_abnormal_retinal_apoptosis1.21786805
39MP0005367_renal/urinary_system_phenotyp1.20560634
40MP0000516_abnormal_urinary_system1.20560634
41MP0001188_hyperpigmentation1.18234993
42MP0002210_abnormal_sex_determination1.17392646
43MP0005360_urolithiasis1.16902142
44MP0006292_abnormal_olfactory_placode1.15601989
45MP0000358_abnormal_cell_content/1.14241797
46MP0003941_abnormal_skin_development1.12230008
47MP0005332_abnormal_amino_acid1.11815760
48MP0001145_abnormal_male_reproductive1.10288306
49MP0000653_abnormal_sex_gland1.09601688
50MP0005389_reproductive_system_phenotype1.08947991
51MP0001529_abnormal_vocalization1.08361331
52MP0005084_abnormal_gallbladder_morpholo1.08341398
53MP0005395_other_phenotype1.06924891
54MP0000015_abnormal_ear_pigmentation1.06056057
55MP0005551_abnormal_eye_electrophysiolog1.04915300
56MP0002396_abnormal_hematopoietic_system1.01117815
57MP0001119_abnormal_female_reproductive0.99250889
58MP0000569_abnormal_digit_pigmentation0.98947340
59MP0001697_abnormal_embryo_size0.97005913
60MP0002019_abnormal_tumor_incidence0.94528784
61MP0005408_hypopigmentation0.93967894
62MP0000313_abnormal_cell_death0.89840464
63MP0005365_abnormal_bile_salt0.89759065
64MP0003698_abnormal_male_reproductive0.88995187
65MP0002095_abnormal_skin_pigmentation0.88141175
66MP0005646_abnormal_pituitary_gland0.87208206
67MP0005253_abnormal_eye_physiology0.87031760
68MP0003656_abnormal_erythrocyte_physiolo0.86974740
69MP0001919_abnormal_reproductive_system0.85643675
70MP0000689_abnormal_spleen_morphology0.84298416
71MP0003123_paternal_imprinting0.82420346
72MP0008873_increased_physiological_sensi0.81998690
73MP0005174_abnormal_tail_pigmentation0.80394607
74MP0001984_abnormal_olfaction0.78937595
75MP0002751_abnormal_autonomic_nervous0.78337133
76MP0009046_muscle_twitch0.77178312
77MP0000350_abnormal_cell_proliferation0.75544271
78MP0000538_abnormal_urinary_bladder0.75397005
79MP0005266_abnormal_metabolism0.75354702
80MP0004142_abnormal_muscle_tone0.74859574
81MP0002938_white_spotting0.74644341
82MP0001730_embryonic_growth_arrest0.74239212
83MP0001666_abnormal_nutrient_absorption0.74110267
84MP0005380_embryogenesis_phenotype0.73740958
85MP0001672_abnormal_embryogenesis/_devel0.73740958
86MP0003937_abnormal_limbs/digits/tail_de0.73641212
87MP0002084_abnormal_developmental_patter0.71684470
88MP0003567_abnormal_fetal_cardiomyocyte0.70358893
89MP0000631_abnormal_neuroendocrine_gland0.70060425
90MP0000371_diluted_coat_color0.69632206
91MP0010329_abnormal_lipoprotein_level0.69178555
92MP0002132_abnormal_respiratory_system0.69099109
93MP0009703_decreased_birth_body0.68619375
94MP0005220_abnormal_exocrine_pancreas0.68524802
95MP0002876_abnormal_thyroid_physiology0.67777850
96MP0004019_abnormal_vitamin_homeostasis0.66458005
97MP0003221_abnormal_cardiomyocyte_apopto0.66172164
98MP0002234_abnormal_pharynx_morphology0.65952159
99MP0000383_abnormal_hair_follicle0.64484445
100MP0002722_abnormal_immune_system0.63802438

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)3.79745485
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.72692412
3Abnormality of chromosome stability (HP:0003220)3.42046726
4Aplasia/Hypoplasia of the uvula (HP:0010293)3.31944404
5Acute necrotizing encephalopathy (HP:0006965)3.28378904
6Increased CSF lactate (HP:0002490)3.24781317
7Meckel diverticulum (HP:0002245)3.20655538
8Volvulus (HP:0002580)3.13668886
9Abnormality of the ileum (HP:0001549)3.12037626
10Abnormal mitochondria in muscle tissue (HP:0008316)3.06737158
11Acute encephalopathy (HP:0006846)3.06045037
12Mitochondrial inheritance (HP:0001427)3.04180928
13Tubulointerstitial nephritis (HP:0001970)3.03943731
14Abnormality of the preputium (HP:0100587)3.03001673
15Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.81772679
16Abnormality of alanine metabolism (HP:0010916)2.81772679
17Hyperalaninemia (HP:0003348)2.81772679
18Progressive macrocephaly (HP:0004481)2.76290655
19Cerebral edema (HP:0002181)2.75216037
20Microvesicular hepatic steatosis (HP:0001414)2.70985551
21Type I transferrin isoform profile (HP:0003642)2.70960063
22Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.65464524
23Abnormal protein N-linked glycosylation (HP:0012347)2.65464524
24Abnormal protein glycosylation (HP:0012346)2.65464524
25Abnormal glycosylation (HP:0012345)2.65464524
26Increased hepatocellular lipid droplets (HP:0006565)2.63524458
27Increased serum pyruvate (HP:0003542)2.60614122
28Increased serum lactate (HP:0002151)2.59299407
29Pancreatic cysts (HP:0001737)2.58087732
30Hepatic necrosis (HP:0002605)2.55290031
31Hepatocellular necrosis (HP:0001404)2.55051499
32Renal cortical cysts (HP:0000803)2.52066939
333-Methylglutaconic aciduria (HP:0003535)2.47433491
34Clubbing of toes (HP:0100760)2.41730884
35Medial flaring of the eyebrow (HP:0010747)2.38808834
36Small intestinal stenosis (HP:0012848)2.36940957
37Duodenal stenosis (HP:0100867)2.36940957
38Myelodysplasia (HP:0002863)2.36039197
39Lipid accumulation in hepatocytes (HP:0006561)2.31468343
40Lactic acidosis (HP:0003128)2.31408662
41Hyperglycinemia (HP:0002154)2.28977010
42Abnormality of glycolysis (HP:0004366)2.25531346
43Abnormality of the renal cortex (HP:0011035)2.24254262
44Abnormality of serum amino acid levels (HP:0003112)2.22614406
45Pancreatic fibrosis (HP:0100732)2.21781943
46Colon cancer (HP:0003003)2.17753518
47Methylmalonic acidemia (HP:0002912)2.10885123
48Abnormality of the duodenum (HP:0002246)2.08103073
49Lethargy (HP:0001254)2.04320673
50Sloping forehead (HP:0000340)2.02319845
51Nephronophthisis (HP:0000090)2.01980059
52Proximal tubulopathy (HP:0000114)1.98929721
53Increased intramyocellular lipid droplets (HP:0012240)1.95994061
54Abnormality of methionine metabolism (HP:0010901)1.94658503
55Dyschromatopsia (HP:0007641)1.93866915
56Abnormality of aspartate family amino acid metabolism (HP:0010899)1.93659060
57Abnormal hair whorl (HP:0010721)1.93479329
58Reduced antithrombin III activity (HP:0001976)1.91836517
59Abnormality of the labia minora (HP:0012880)1.90782420
60Embryonal renal neoplasm (HP:0011794)1.89242501
61Renal Fanconi syndrome (HP:0001994)1.89084845
62Neoplasm of the adrenal gland (HP:0100631)1.83235391
63Abnormality of midbrain morphology (HP:0002418)1.82538384
64Molar tooth sign on MRI (HP:0002419)1.82538384
65Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.82485866
66Aplasia/Hypoplasia of the tibia (HP:0005772)1.82271839
67Congenital primary aphakia (HP:0007707)1.81182996
68True hermaphroditism (HP:0010459)1.80756247
69Abnormality of the pons (HP:0007361)1.80608997
70Optic disc pallor (HP:0000543)1.79382995
71Pancreatic islet-cell hyperplasia (HP:0004510)1.78971337
72Absent thumb (HP:0009777)1.77800042
73Birth length less than 3rd percentile (HP:0003561)1.77763745
74Methylmalonic aciduria (HP:0012120)1.76948019
75Exercise intolerance (HP:0003546)1.75824576
76Nephroblastoma (Wilms tumor) (HP:0002667)1.75460945
77Intestinal atresia (HP:0011100)1.73945812
78Abnormality of macular pigmentation (HP:0008002)1.73682309
79Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.72912871
80Bone marrow hypocellularity (HP:0005528)1.72675220
81Abnormality of serine family amino acid metabolism (HP:0010894)1.72625971
82Abnormality of glycine metabolism (HP:0010895)1.72625971
83Abnormality of vitamin B metabolism (HP:0004340)1.71780254
84Pancytopenia (HP:0001876)1.70388884
85Glycosuria (HP:0003076)1.69630524
86Abnormality of urine glucose concentration (HP:0011016)1.69630524
87Astigmatism (HP:0000483)1.69247476
88Hypoplasia of the pons (HP:0012110)1.68677032
89Abnormality of the renal medulla (HP:0100957)1.68453748
90Nephrogenic diabetes insipidus (HP:0009806)1.68248219
91Small hand (HP:0200055)1.68051606
92Ependymoma (HP:0002888)1.67926774
93Abnormality of the vitamin B12 metabolism (HP:0004341)1.67824604
94Abnormality of B cell number (HP:0010975)1.67791424
95Ketoacidosis (HP:0001993)1.67749331
96Abnormality of DNA repair (HP:0003254)1.67643082
97Abolished electroretinogram (ERG) (HP:0000550)1.67589107
98Spontaneous abortion (HP:0005268)1.66741700
99Triphalangeal thumb (HP:0001199)1.66602138
100Abnormality of the carotid arteries (HP:0005344)1.66350244

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NUAK13.22578701
2MST43.04046641
3SRPK13.00453582
4EIF2AK32.81021738
5BUB12.68643458
6PBK2.68048111
7BMPR1B2.44498651
8FRK2.29422335
9MAP4K22.28021664
10VRK22.26287368
11PLK42.23346852
12ACVR1B2.09997081
13ZAK2.09582028
14EIF2AK12.08395124
15MKNK22.07842315
16TRIM282.07718138
17CDC72.04008011
18PDK22.02445679
19CCNB11.93675185
20MKNK11.87704155
21TAOK31.83554941
22TSSK61.80453870
23TAF11.64793182
24NEK21.57574955
25NEK11.56673532
26VRK11.53794054
27PLK31.50716210
28TTK1.50246323
29GRK11.41924019
30MAP3K121.38033205
31BRSK21.23892619
32STK391.18956941
33ADRBK21.18681288
34TEC1.17765921
35ERBB31.17064939
36PLK21.13748483
37WEE11.13583255
38PIK3CG1.09958869
39WNK31.07070688
40SCYL21.04987959
41STK161.03959160
42MAP3K41.03130494
43EIF2AK21.03118492
44ATR1.00868000
45OXSR11.00820057
46PLK10.99405238
47INSRR0.94589414
48CAMKK20.91959634
49AKT30.91216478
50WNK40.85320599
51FLT30.83800625
52TXK0.82674417
53BCR0.82477762
54CSNK1G10.82378657
55ATM0.80575687
56BCKDK0.78047356
57TNIK0.71119107
58PNCK0.68618176
59SIK30.64486303
60MAPK130.64411915
61MAP2K70.64069069
62CHEK20.63105045
63STK30.61562066
64AURKB0.61023416
65TESK20.59411832
66CHEK10.57898289
67LATS10.57638339
68PAK30.57454583
69PRKCE0.56908437
70PRKCI0.56462340
71CSNK1G30.56390503
72BMPR20.55463662
73STK40.52203494
74TGFBR10.51375350
75CDK80.49785925
76RPS6KB20.49045440
77MAPKAPK50.48614094
78PRKCQ0.46770358
79DYRK30.45999912
80RPS6KA50.45337990
81CSNK2A20.43460306
82CSNK2A10.43435399
83CASK0.43145591
84CSNK1G20.41741393
85STK38L0.41228181
86CSNK1A1L0.40726739
87NME20.40403086
88CHUK0.39908579
89TNK20.37700950
90TLK10.37621842
91DYRK20.37509831
92CDK90.33854069
93ADRBK10.33330910
94MARK30.32568800
95ITK0.31204205
96CSNK1D0.28915911
97DAPK10.28872259
98CSNK1A10.28758837
99PIK3CA0.28551953
100IGF1R0.26791084

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.79184818
2Protein export_Homo sapiens_hsa030603.41750271
3Homologous recombination_Homo sapiens_hsa034402.93123864
4Mismatch repair_Homo sapiens_hsa034302.92703115
5Non-homologous end-joining_Homo sapiens_hsa034502.88304250
6Fanconi anemia pathway_Homo sapiens_hsa034602.68578752
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.61290676
8DNA replication_Homo sapiens_hsa030302.44768531
9Oxidative phosphorylation_Homo sapiens_hsa001902.20494533
10Basal transcription factors_Homo sapiens_hsa030222.17168599
11RNA polymerase_Homo sapiens_hsa030202.15308518
12RNA degradation_Homo sapiens_hsa030182.08947027
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00797955
14Base excision repair_Homo sapiens_hsa034101.93975002
15Parkinsons disease_Homo sapiens_hsa050121.93629247
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93139388
17Propanoate metabolism_Homo sapiens_hsa006401.92341768
18One carbon pool by folate_Homo sapiens_hsa006701.91889732
19RNA transport_Homo sapiens_hsa030131.85017880
20Nucleotide excision repair_Homo sapiens_hsa034201.84749467
21Spliceosome_Homo sapiens_hsa030401.83376783
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82245371
23Selenocompound metabolism_Homo sapiens_hsa004501.65852457
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.65782497
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.61845274
26Caffeine metabolism_Homo sapiens_hsa002321.54311183
27Butanoate metabolism_Homo sapiens_hsa006501.53348224
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51322805
29Fatty acid elongation_Homo sapiens_hsa000621.51140221
30Peroxisome_Homo sapiens_hsa041461.41314190
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38634087
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.34744243
33Huntingtons disease_Homo sapiens_hsa050161.33515256
34Pyrimidine metabolism_Homo sapiens_hsa002401.32995593
35Pyruvate metabolism_Homo sapiens_hsa006201.28183689
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20973610
37Sulfur metabolism_Homo sapiens_hsa009201.17805019
38Steroid biosynthesis_Homo sapiens_hsa001001.15218906
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12459427
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12226322
41Nitrogen metabolism_Homo sapiens_hsa009101.10853658
42Alzheimers disease_Homo sapiens_hsa050101.03316576
43Purine metabolism_Homo sapiens_hsa002301.02188189
44mRNA surveillance pathway_Homo sapiens_hsa030150.95036990
45Cell cycle_Homo sapiens_hsa041100.93371149
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90956621
47Pentose and glucuronate interconversions_Homo sapiens_hsa000400.89665157
48Primary immunodeficiency_Homo sapiens_hsa053400.87474988
49Tryptophan metabolism_Homo sapiens_hsa003800.86736346
50Ribosome_Homo sapiens_hsa030100.85759029
51Folate biosynthesis_Homo sapiens_hsa007900.85595402
52Fatty acid metabolism_Homo sapiens_hsa012120.83788708
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82243905
54Metabolic pathways_Homo sapiens_hsa011000.81028336
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80546047
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80482272
57Chemical carcinogenesis_Homo sapiens_hsa052040.80359485
58Fatty acid degradation_Homo sapiens_hsa000710.77971676
59Retinol metabolism_Homo sapiens_hsa008300.77955101
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77505798
61Linoleic acid metabolism_Homo sapiens_hsa005910.77196719
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76550915
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76479721
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.75677774
65N-Glycan biosynthesis_Homo sapiens_hsa005100.72149286
66Glutathione metabolism_Homo sapiens_hsa004800.72086737
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68362515
68Vitamin B6 metabolism_Homo sapiens_hsa007500.66840882
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65919525
70p53 signaling pathway_Homo sapiens_hsa041150.64885986
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64328238
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63838752
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.62060502
74Phototransduction_Homo sapiens_hsa047440.61798776
75Carbon metabolism_Homo sapiens_hsa012000.58972556
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57111170
77Vitamin digestion and absorption_Homo sapiens_hsa049770.57067251
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.55244107
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54987256
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54366638
81Oocyte meiosis_Homo sapiens_hsa041140.53722450
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51147438
83beta-Alanine metabolism_Homo sapiens_hsa004100.50840830
84Fat digestion and absorption_Homo sapiens_hsa049750.47267982
85Sphingolipid metabolism_Homo sapiens_hsa006000.44193812
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42809088
87Glycerolipid metabolism_Homo sapiens_hsa005610.42483549
88Regulation of autophagy_Homo sapiens_hsa041400.41168632
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.36042788
90Systemic lupus erythematosus_Homo sapiens_hsa053220.35889496
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35741443
92Asthma_Homo sapiens_hsa053100.32565760
93Ether lipid metabolism_Homo sapiens_hsa005650.32199001
94Arachidonic acid metabolism_Homo sapiens_hsa005900.31703351
95Legionellosis_Homo sapiens_hsa051340.31318290
96Biosynthesis of amino acids_Homo sapiens_hsa012300.31232482
97Starch and sucrose metabolism_Homo sapiens_hsa005000.30633250
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26837175
99Arginine and proline metabolism_Homo sapiens_hsa003300.26192226
100Renin-angiotensin system_Homo sapiens_hsa046140.23275282

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