GPR84

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)7.97476073
2modulation by symbiont of host defense response (GO:0052031)7.97476073
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.97476073
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.97476073
5positive regulation by organism of defense response of other organism involved in symbiotic interact7.97476073
6modulation by symbiont of host immune response (GO:0052553)7.97476073
7response to peptidoglycan (GO:0032494)6.89404292
8macrophage activation involved in immune response (GO:0002281)5.79706027
9positive regulation of chemokine biosynthetic process (GO:0045080)5.78919485
10response to immune response of other organism involved in symbiotic interaction (GO:0052564)5.45727992
11response to host immune response (GO:0052572)5.45727992
12neutrophil activation involved in immune response (GO:0002283)5.19213136
13microglial cell activation (GO:0001774)4.97051969
14hydrogen peroxide biosynthetic process (GO:0050665)4.96739421
15response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.91116949
16response to host (GO:0075136)4.91116949
17response to host defenses (GO:0052200)4.91116949
18lipopolysaccharide-mediated signaling pathway (GO:0031663)4.88094608
19regulation of interferon-beta biosynthetic process (GO:0045357)4.81687659
20respiratory burst (GO:0045730)4.75436902
21regulation of chemokine biosynthetic process (GO:0045073)4.73998045
22positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.71657735
23immunoglobulin mediated immune response (GO:0016064)4.49434840
24positive regulation of interferon-alpha production (GO:0032727)4.48970408
25reactive oxygen species biosynthetic process (GO:1903409)4.45573243
26positive regulation of heat generation (GO:0031652)4.45566997
27regulation of vitamin metabolic process (GO:0030656)4.43496393
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.37887145
29regulation of interferon-alpha production (GO:0032647)4.33627627
30positive regulation of cellular amide metabolic process (GO:0034250)4.29658582
31regulation of fever generation (GO:0031620)4.25263824
32positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.16530230
33superoxide anion generation (GO:0042554)4.12531520
34macrophage activation (GO:0042116)4.11690588
35negative regulation of interleukin-12 production (GO:0032695)4.07869479
36regulation of cytokine secretion involved in immune response (GO:0002739)4.05064114
37positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.93881836
38monocyte chemotaxis (GO:0002548)3.93351684
39positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.90525138
40positive regulation of mast cell activation involved in immune response (GO:0033008)3.88314913
41positive regulation of mast cell degranulation (GO:0043306)3.88314913
42myeloid cell activation involved in immune response (GO:0002275)3.83969823
43negative regulation of interleukin-17 production (GO:0032700)3.83158103
44granulocyte activation (GO:0036230)3.81707596
45leukocyte aggregation (GO:0070486)3.81231697
46detection of molecule of bacterial origin (GO:0032490)3.78895119
47regulation of T-helper 1 cell differentiation (GO:0045625)3.75627533
48regulation of podosome assembly (GO:0071801)3.67591533
49positive regulation of toll-like receptor signaling pathway (GO:0034123)3.64938653
50negative regulation of cytokine production involved in immune response (GO:0002719)3.64625634
51response to muramyl dipeptide (GO:0032495)3.63876014
52NIK/NF-kappaB signaling (GO:0038061)3.62544735
53positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.60489981
54positive regulation of chemokine production (GO:0032722)3.57246737
55germinal center formation (GO:0002467)3.56083144
56positive regulation of interferon-beta production (GO:0032728)3.55997455
57positive regulation of mast cell activation (GO:0033005)3.51217861
58neutrophil activation (GO:0042119)3.50149249
59regulation of mast cell degranulation (GO:0043304)3.49949049
60I-kappaB phosphorylation (GO:0007252)3.48804894
61cellular response to type I interferon (GO:0071357)3.47323339
62type I interferon signaling pathway (GO:0060337)3.47323339
63regulation of mononuclear cell migration (GO:0071675)3.44606413
64regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.44335172
65response to type I interferon (GO:0034340)3.43234517
66regulation of interleukin-8 biosynthetic process (GO:0045414)3.42746752
67response to protozoan (GO:0001562)3.38509728
68myeloid dendritic cell differentiation (GO:0043011)3.37299151
69positive regulation of antigen processing and presentation (GO:0002579)3.36154870
70regulation of heat generation (GO:0031650)3.35127985
71B cell mediated immunity (GO:0019724)3.33827925
72glycosphingolipid catabolic process (GO:0046479)3.30024726
73regulation of mast cell activation involved in immune response (GO:0033006)3.28436190
74negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.27758971
75positive regulation of acute inflammatory response (GO:0002675)3.27688869
76positive regulation of NF-kappaB import into nucleus (GO:0042346)3.27296819
77lymphocyte chemotaxis (GO:0048247)3.27252881
78modulation of growth of symbiont involved in interaction with host (GO:0044144)3.23015377
79regulation of growth of symbiont in host (GO:0044126)3.23015377
80negative regulation of growth of symbiont in host (GO:0044130)3.23015377
81negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.23015377
82regulation of macrophage chemotaxis (GO:0010758)3.22770672
83interferon-gamma-mediated signaling pathway (GO:0060333)3.21234541
84cellular response to thyroid hormone stimulus (GO:0097067)3.20111677
85positive regulation of leukocyte degranulation (GO:0043302)3.18860245
86negative regulation of myeloid cell apoptotic process (GO:0033033)3.18527531
87positive regulation of type 2 immune response (GO:0002830)3.16655538
88regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.16481464
89negative regulation of nitric oxide biosynthetic process (GO:0045019)3.16239007
90positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.15647368
91response to interferon-alpha (GO:0035455)3.14086724
92neutrophil mediated immunity (GO:0002446)3.13939473
93positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.13791957
94regulation of T-helper 2 cell differentiation (GO:0045628)3.12106691
95T-helper 1 type immune response (GO:0042088)3.11519875
96regulation of interleukin-17 production (GO:0032660)3.11437890
97regulation of vitamin D biosynthetic process (GO:0060556)3.11147233
98cellular extravasation (GO:0045123)3.08835469
99branching involved in labyrinthine layer morphogenesis (GO:0060670)3.08723996
100low-density lipoprotein particle clearance (GO:0034383)3.08529721
101neutrophil chemotaxis (GO:0030593)3.08170523
102positive regulation of interleukin-6 production (GO:0032755)3.07790595
103regulation of dendritic cell antigen processing and presentation (GO:0002604)3.07606819
104production of molecular mediator involved in inflammatory response (GO:0002532)3.07374605
105positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.07063177
106regulation of chronic inflammatory response (GO:0002676)3.06293714
107eosinophil chemotaxis (GO:0048245)3.05728009
108regulation of membrane protein ectodomain proteolysis (GO:0051043)3.03133824
109positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.02619255
110regulation of heterotypic cell-cell adhesion (GO:0034114)3.01760939
111positive regulation of gamma-delta T cell activation (GO:0046645)3.01667462
112negative regulation of viral genome replication (GO:0045071)2.99890286
113oligosaccharide catabolic process (GO:0009313)2.99787100
114regulation of nitric oxide biosynthetic process (GO:0045428)2.99691246
115regulation of interleukin-12 production (GO:0032655)2.99601940
116neutrophil migration (GO:1990266)2.99438168
117myeloid dendritic cell activation (GO:0001773)2.98996507
118negative regulation of cell killing (GO:0031342)2.98492054
119negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.98492054
120regulation of mast cell activation (GO:0033003)2.96458321
121cellular response to lipopolysaccharide (GO:0071222)2.96252404
122defense response to protozoan (GO:0042832)2.96235567
123positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.95221887
124cellular response to molecule of bacterial origin (GO:0071219)2.94275322
125glycolipid catabolic process (GO:0019377)2.94121721
126negative regulation of production of molecular mediator of immune response (GO:0002701)2.92789188
127positive regulation of nitric oxide biosynthetic process (GO:0045429)2.90975072
128regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.90663520
129positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.89723030
130positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.89652601
131regulation of NF-kappaB import into nucleus (GO:0042345)2.87999214
132detection of other organism (GO:0098543)2.81803402
133regulation of lymphocyte chemotaxis (GO:1901623)2.81027114
134cellular response to biotic stimulus (GO:0071216)2.80967730
135negative regulation of lipid storage (GO:0010888)2.79787611
136detection of external biotic stimulus (GO:0098581)2.79702927
137regulation of antigen processing and presentation (GO:0002577)2.77958989

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse7.46059265
2BP1_19119308_ChIP-ChIP_Hs578T_Human7.38443366
3IRF8_22096565_ChIP-ChIP_GC-B_Human6.64196208
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.77969548
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.46565911
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.41528454
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse4.02642664
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.93809027
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.71179824
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.68357449
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.25566103
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.18885022
13MYB_21317192_ChIP-Seq_ERMYB_Mouse3.15055410
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.72148020
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.63365889
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.59524783
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.58543340
18* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.54773215
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.39617423
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.31643146
21BRD4_27068464_Chip-Seq_AML-cells_Mouse2.19041146
22* SPI1_23547873_ChIP-Seq_NB4_Human2.07119233
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.03694007
24PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.00366087
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.98876035
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.97914691
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.86538560
28VDR_24787735_ChIP-Seq_THP-1_Human1.80052522
29PU_27001747_Chip-Seq_BMDM_Mouse1.78218173
30* VDR_24763502_ChIP-Seq_THP-1_Human1.75994397
31SPI1_23127762_ChIP-Seq_K562_Human1.75958301
32* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.69769179
33* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.64022331
34SCL_19346495_ChIP-Seq_HPC-7_Human1.62153436
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59875910
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.57690405
37PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.56571081
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53545795
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52090188
40CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.41270734
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.39817143
42MYB_26560356_Chip-Seq_TH2_Human1.37202730
43* RUNX_20019798_ChIP-Seq_JUKART_Human1.35995294
44NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.35710394
45* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33376181
46TP63_17297297_ChIP-ChIP_HaCaT_Human1.31682609
47MAF_26560356_Chip-Seq_TH1_Human1.29289528
48VDR_21846776_ChIP-Seq_THP-1_Human1.25851371
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.25090177
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22011256
51FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.20321496
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17443870
53* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16986769
54* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16972588
55* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16293879
56GATA1_22025678_ChIP-Seq_K562_Human1.15501128
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.15189286
58* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13282259
59* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12534723
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10985111
61GATA3_26560356_Chip-Seq_TH2_Human1.09853204
62MYB_26560356_Chip-Seq_TH1_Human1.09836435
63KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07314743
64TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06273840
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05705312
66MYC_22102868_ChIP-Seq_BL_Human1.05317735
67* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04881771
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04675328
69STAT1_20625510_ChIP-Seq_HELA_Human1.03239609
70GATA3_27048872_Chip-Seq_THYMUS_Human1.02837445
71* UTX_26944678_Chip-Seq_JUKART_Human1.01985818
72GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00402272
73VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95736452
74* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95716887
75SPI1_20517297_ChIP-Seq_HL60_Human0.94412243
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.93901041
77EGR1_19032775_ChIP-ChIP_M12_Human0.92039051
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91518731
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88664106
80RARG_19884340_ChIP-ChIP_MEFs_Mouse0.87933966
81TRIM28_21343339_ChIP-Seq_HEK293_Human0.87259671
82SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86390992
83CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85162860
84* BCL6_27268052_Chip-Seq_Bcells_Human0.84462706
85SOX2_20726797_ChIP-Seq_SW620_Human0.84154928
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84089954
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84055622
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83414256
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82869020
90* BCOR_27268052_Chip-Seq_Bcells_Human0.82742970
91* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.82527026
92* ELK3_25401928_ChIP-Seq_HUVEC_Human0.82207064
93GATA2_19941826_ChIP-Seq_K562_Human0.78981757
94JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77870184
95GATA1_19941826_ChIP-Seq_K562_Human0.77397723
96GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77084890
97* TCF7_22412390_ChIP-Seq_EML_Mouse0.76776506
98NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74167128
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74167128
100GATA1_22383799_ChIP-Seq_G1ME_Mouse0.74153624
101* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.73562507
102ESR1_21235772_ChIP-Seq_MCF-7_Human0.73522713
103JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73375347
104* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.72170713
105MAF_26560356_Chip-Seq_TH2_Human0.71899217
106FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.71291225
107GATA1_19941827_ChIP-Seq_MEL_Mouse0.66282662
108TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.65134267
109TFEB_21752829_ChIP-Seq_HELA_Human0.62943880
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.62269728
111CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.61461569
112P63_26484246_Chip-Seq_KERATINOCYTES_Human0.59975626
113* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.59197328
114KDM2B_26808549_Chip-Seq_DND41_Human0.58738410
115* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.58319558
116LXR_22292898_ChIP-Seq_THP-1_Human0.57562902

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009785_altered_susceptibility_to4.34253852
2MP0003303_peritoneal_inflammation4.14937252
3MP0003436_decreased_susceptibility_to4.06867515
4MP0001835_abnormal_antigen_presentation3.71954473
5MP0006082_CNS_inflammation3.59751780
6MP0002419_abnormal_innate_immunity3.43364374
7MP0002148_abnormal_hypersensitivity_rea3.32514264
8MP0003724_increased_susceptibility_to3.21383189
9MP0005000_abnormal_immune_tolerance3.10289384
10MP0005058_abnormal_lysosome_morphology3.08812375
11MP0005025_abnormal_response_to2.99135323
12MP0005387_immune_system_phenotype2.60838235
13MP0001790_abnormal_immune_system2.60838235
14MP0004510_myositis2.50169312
15MP0002452_abnormal_antigen_presenting2.49562393
16MP0003172_abnormal_lysosome_physiology2.48848266
17MP0001533_abnormal_skeleton_physiology2.45232766
18MP0002723_abnormal_immune_serum2.39471113
19MP0001800_abnormal_humoral_immune2.29484022
20MP0003075_altered_response_to2.27516045
21MP0005464_abnormal_platelet_physiology2.25083592
22MP0009764_decreased_sensitivity_to2.24759023
23MP0002139_abnormal_hepatobiliary_system2.19018000
24MP0000685_abnormal_immune_system2.16213288
25MP0004947_skin_inflammation2.14022734
26MP0000343_altered_response_to2.12070667
27MP0009278_abnormal_bone_marrow2.11331826
28MP0005671_abnormal_response_to2.07711365
29MP0005167_abnormal_blood-brain_barrier2.04958653
30MP0001819_abnormal_immune_cell2.04348305
31MP0002420_abnormal_adaptive_immunity2.01340176
32MP0000604_amyloidosis1.97007116
33MP0001845_abnormal_inflammatory_respons1.96127342
34MP0008469_abnormal_protein_level1.91375067
35MP0003448_altered_tumor_morphology1.86243047
36MP0003195_calcinosis1.83831652
37MP0004858_abnormal_nervous_system1.77903289
38MP0002405_respiratory_system_inflammati1.77634191
39MP0009840_abnormal_foam_cell1.76518813
40MP0008004_abnormal_stomach_pH1.75640337
41MP0003806_abnormal_nucleotide_metabolis1.72176704
42MP0003191_abnormal_cellular_cholesterol1.71324849
43MP0001853_heart_inflammation1.63318211
44MP0006054_spinal_hemorrhage1.55308504
45MP0005166_decreased_susceptibility_to1.52906340
46MP0002998_abnormal_bone_remodeling1.46637494
47MP0010155_abnormal_intestine_physiology1.45469079
48MP0003828_pulmonary_edema1.44713653
49MP0002006_tumorigenesis1.43885871
50MP0009333_abnormal_splenocyte_physiolog1.43425988
51MP0003690_abnormal_glial_cell1.39466025
52MP0000858_altered_metastatic_potential1.39289873
53MP0005164_abnormal_response_to1.38060159
54MP0003300_gastrointestinal_ulcer1.37127327
55MP0000716_abnormal_immune_system1.36449368
56MP0005310_abnormal_salivary_gland1.32900264
57MP0003183_abnormal_peptide_metabolism1.32726949
58MP0005397_hematopoietic_system_phenotyp1.27838342
59MP0001545_abnormal_hematopoietic_system1.27838342
60MP0002398_abnormal_bone_marrow1.20547408
61MP0002277_abnormal_respiratory_mucosa1.15961438
62MP0005390_skeleton_phenotype1.11859652
63MP0003186_abnormal_redox_activity1.10376176
64MP0003646_muscle_fatigue1.09259020
65MP0009763_increased_sensitivity_to1.08616421
66MP0002429_abnormal_blood_cell1.06119612
67MP0000689_abnormal_spleen_morphology1.06051641
68MP0005083_abnormal_biliary_tract1.03056076
69MP0002332_abnormal_exercise_endurance1.02407856
70MP0001851_eye_inflammation1.02117467
71MP0005076_abnormal_cell_differentiation1.01194107
72MP0001501_abnormal_sleep_pattern0.99401456
73MP0000569_abnormal_digit_pigmentation0.96069875
74MP0010307_abnormal_tumor_latency0.93462431
75MP0002933_joint_inflammation0.92103542
76MP0002722_abnormal_immune_system0.91122516
77MP0009765_abnormal_xenobiotic_induced0.89253111
78MP0000249_abnormal_blood_vessel0.87388032
79MP0002138_abnormal_hepatobiliary_system0.86451111
80MP0001542_abnormal_bone_strength0.84936960
81MP0003656_abnormal_erythrocyte_physiolo0.84376914
82MP0004782_abnormal_surfactant_physiolog0.84191615
83MP0005257_abnormal_intraocular_pressure0.82631912
84MP0001663_abnormal_digestive_system0.81802008
85MP0003453_abnormal_keratinocyte_physiol0.79395457
86MP0003566_abnormal_cell_adhesion0.77740070
87MP0005023_abnormal_wound_healing0.77171934
88MP0003091_abnormal_cell_migration0.76161914
89MP0002254_reproductive_system_inflammat0.74576679
90MP0008874_decreased_physiological_sensi0.74355057
91MP0002837_dystrophic_cardiac_calcinosis0.73339335
92MP0003329_amyloid_beta_deposits0.72259506
93MP0008260_abnormal_autophagy0.70473923
94MP0002166_altered_tumor_susceptibility0.69539009
95MP0003795_abnormal_bone_structure0.66035067
96MP0004883_abnormal_blood_vessel0.64169510
97MP0005647_abnormal_sex_gland0.63383043
98MP0008873_increased_physiological_sensi0.63357676
99MP0000465_gastrointestinal_hemorrhage0.61536658
100MP0000920_abnormal_myelination0.59171328
101MP0005319_abnormal_enzyme/_coenzyme0.58173744
102MP0002090_abnormal_vision0.57585112
103MP0000371_diluted_coat_color0.56974476
104MP0003221_abnormal_cardiomyocyte_apopto0.56755667
105MP0004808_abnormal_hematopoietic_stem0.56440644
106MP0005595_abnormal_vascular_smooth0.56415056
107MP0003763_abnormal_thymus_physiology0.55884285
108MP0005584_abnormal_enzyme/coenzyme_acti0.54836368
109MP0005165_increased_susceptibility_to0.54803850
110MP0001873_stomach_inflammation0.54381565
111MP0002136_abnormal_kidney_physiology0.53952513
112MP0005451_abnormal_body_composition0.53839870
113MP0000767_abnormal_smooth_muscle0.51919832
114MP0005535_abnormal_body_temperature0.50484377
115MP0005174_abnormal_tail_pigmentation0.49438043
116MP0000609_abnormal_liver_physiology0.49365337

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)8.18855277
2Eczematoid dermatitis (HP:0000976)7.53976575
3Recurrent bacterial skin infections (HP:0005406)7.32370818
4Recurrent gram-negative bacterial infections (HP:0005420)6.78245556
5Abnormality of macrophages (HP:0004311)5.73702484
6Mediastinal lymphadenopathy (HP:0100721)5.71809938
7Stomatitis (HP:0010280)5.29078367
8Systemic lupus erythematosus (HP:0002725)5.26433253
9Increased cerebral lipofuscin (HP:0011813)4.97177220
10Increased neuronal autofluorescent lipopigment (HP:0002074)4.71617848
11Autoimmune thrombocytopenia (HP:0001973)4.61267980
12Gingivitis (HP:0000230)4.42796217
13Elevated erythrocyte sedimentation rate (HP:0003565)4.38623390
14Recurrent skin infections (HP:0001581)4.16286012
15Obstructive lung disease (HP:0006536)4.15514136
16Chronic obstructive pulmonary disease (HP:0006510)4.15514136
17Orchitis (HP:0100796)4.09176090
18Glomerulonephritis (HP:0000099)4.07651849
19Vacuolated lymphocytes (HP:0001922)4.02803992
20Myositis (HP:0100614)3.98803776
21Mutism (HP:0002300)3.96883162
22Optic neuritis (HP:0100653)3.79336032
23Retrobulbar optic neuritis (HP:0100654)3.79336032
24Axonal loss (HP:0003447)3.70982021
25Disinhibition (HP:0000734)3.53868698
26Prostate neoplasm (HP:0100787)3.52750328
27Neurofibrillary tangles (HP:0002185)3.40570926
28Urticaria (HP:0001025)3.39909674
29Vasculitis (HP:0002633)3.36696116
30Thick nail (HP:0001805)3.35592003
31Recurrent fungal infections (HP:0002841)3.33929785
32Increased IgM level (HP:0003496)3.33879933
33Tetraparesis (HP:0002273)3.32124742
34Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.31244122
35Nuclear cataract (HP:0100018)3.20796239
36Recurrent viral infections (HP:0004429)3.11730573
37Pustule (HP:0200039)3.09722844
38Dysostosis multiplex (HP:0000943)3.09563009
39Abnormality of glycosphingolipid metabolism (HP:0004343)3.09113489
40Abnormality of glycolipid metabolism (HP:0010969)3.09113489
41Abnormality of liposaccharide metabolism (HP:0010968)3.09113489
42Basal ganglia calcification (HP:0002135)3.08189956
43Cellulitis (HP:0100658)3.03508253
44Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.01450101
45Interstitial pulmonary disease (HP:0006530)2.93075478
46Pulmonary infiltrates (HP:0002113)2.81899498
47Agnosia (HP:0010524)2.74173283
48Abnormality of the vasculature of the conjunctiva (HP:0008054)2.73317034
49Periodontitis (HP:0000704)2.67352279
50Myocardial infarction (HP:0001658)2.60251412
51Nephritis (HP:0000123)2.59581239
52Neuronal loss in central nervous system (HP:0002529)2.57821104
53Hepatosplenomegaly (HP:0001433)2.56522003
54Recurrent pneumonia (HP:0006532)2.55478624
55Inappropriate behavior (HP:0000719)2.53022563
56Metaphyseal irregularity (HP:0003025)2.51779123
57Hematochezia (HP:0002573)2.49648015
58Mucopolysacchariduria (HP:0008155)2.48496560
59Urinary glycosaminoglycan excretion (HP:0003541)2.48496560
60Gangrene (HP:0100758)2.48381604
61Purpura (HP:0000979)2.48026501
62Progressive neurologic deterioration (HP:0002344)2.46069711
63Meningitis (HP:0001287)2.44990327
64Chronic otitis media (HP:0000389)2.44414643
65Esophageal neoplasm (HP:0100751)2.44161538
66Neoplasm of head and neck (HP:0012288)2.44161538
67Nausea (HP:0002018)2.44033902
68Osteomyelitis (HP:0002754)2.43953297
69Leukocytosis (HP:0001974)2.43275840
70Abnormality of iron homeostasis (HP:0011031)2.42863254
71Polyneuropathy (HP:0001271)2.39580288
72Cerebral inclusion bodies (HP:0100314)2.39361958
73Abnormality of polysaccharide metabolism (HP:0011012)2.33340499
74Abnormality of glycosaminoglycan metabolism (HP:0004371)2.33340499
75Abnormality of mucopolysaccharide metabolism (HP:0011020)2.33340499
76Arterial thrombosis (HP:0004420)2.27680594
77Abnormality of complement system (HP:0005339)2.21181428
78Hypergammaglobulinemia (HP:0010702)2.20937930
79Osteolytic defects of the hand bones (HP:0009699)2.20476669
80Osteolytic defects of the phalanges of the hand (HP:0009771)2.20476669
81Upper motor neuron abnormality (HP:0002127)2.20393418
82Malnutrition (HP:0004395)2.18274925
83Complement deficiency (HP:0004431)2.17779181
84Keratoconjunctivitis sicca (HP:0001097)2.16407909
85Premature loss of primary teeth (HP:0006323)2.15916021
86Amyloidosis (HP:0011034)2.15890902
87Recurrent lower respiratory tract infections (HP:0002783)2.15748845
88Loss of speech (HP:0002371)2.14652596
89Personality changes (HP:0000751)2.13351477
90Gingival bleeding (HP:0000225)2.12179805
91Bone pain (HP:0002653)2.10805424
92Spontaneous hematomas (HP:0007420)2.10520819
93Episodic fever (HP:0001954)2.07581464
94Encephalitis (HP:0002383)2.06921922
95Progressive visual loss (HP:0000529)2.03864459
96Pathologic fracture (HP:0002756)2.02861287
97Memory impairment (HP:0002354)2.00515627
98Recurrent cutaneous fungal infections (HP:0011370)1.99873059
99Chronic mucocutaneous candidiasis (HP:0002728)1.99873059
100Prolonged neonatal jaundice (HP:0006579)1.99534209
101T lymphocytopenia (HP:0005403)1.99353287
102Dementia (HP:0000726)1.97687130
103Peritonitis (HP:0002586)1.96346742
104Abnormality of transition element cation homeostasis (HP:0011030)1.96248039
105Anorexia (HP:0002039)1.95587439
106Keratoconjunctivitis (HP:0001096)1.94379398
107Abnormality of the prostate (HP:0008775)1.93724274
108Parakeratosis (HP:0001036)1.93440387
109Increased serum ferritin (HP:0003281)1.92405245
110Gastrointestinal infarctions (HP:0005244)1.92067876
111Increased IgE level (HP:0003212)1.91525706
112Vertigo (HP:0002321)1.91110772
113Joint swelling (HP:0001386)1.91012022
114Joint hemorrhage (HP:0005261)1.89861978
115Petechiae (HP:0000967)1.88202280
116Pulmonary embolism (HP:0002204)1.87644502
117Peripheral demyelination (HP:0011096)1.86923863
118Arthralgia (HP:0002829)1.86639678
119Apathy (HP:0000741)1.86018851
120Supranuclear gaze palsy (HP:0000605)1.85295383
121Hemoptysis (HP:0002105)1.85249166
122Restrictive lung disease (HP:0002091)1.84409503
123Asymmetric septal hypertrophy (HP:0001670)1.84103039
124Autoimmune hemolytic anemia (HP:0001890)1.83940611
125Eosinophilia (HP:0001880)1.83234871
126Abnormality of the pleura (HP:0002103)1.81470218
127Skin ulcer (HP:0200042)1.81354045
128Abnormality of the pericardium (HP:0001697)1.81052176
129Diminished motivation (HP:0000745)1.80848715
130Sepsis (HP:0100806)1.78620485
131Colitis (HP:0002583)1.77773355

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.45514826
2MAP3K144.08308987
3IRAK33.88176691
4TBK13.84108876
5BLK3.81458289
6IRAK43.35244405
7TYK23.21699719
8DDR22.80330443
9IKBKE2.78118325
10MAP4K12.56440169
11TXK2.51128389
12FGR2.35885201
13ERN12.30270112
14KIT2.20702362
15IKBKB2.12292842
16CSK2.04537302
17PBK2.03721314
18JAK32.00397027
19PRPF4B1.90405088
20JAK11.89541447
21FES1.75795898
22CSF1R1.69527677
23MAP3K131.47106542
24ZAP701.46075909
25HCK1.45710783
26MATK1.44825652
27EPHB11.43362583
28CDC42BPA1.41774309
29PIM21.39849257
30TGFBR21.36572043
31RPS6KA41.35073230
32LYN1.33137596
33SYK1.32332840
34ADRBK21.25960801
35CHUK1.22894020
36ACVR1B1.15931127
37JAK21.10574140
38MARK31.08100506
39LCK1.07418130
40STK100.94620790
41BMX0.94240011
42PRKCD0.90306926
43MAP3K110.88687611
44EGFR0.87938079
45EIF2AK20.86642220
46MAP3K50.84866055
47TYRO30.82029028
48ABL20.81462388
49BTK0.79376419
50NEK90.79142584
51CAMK1D0.77879559
52YES10.75639199
53SIK20.73790884
54NME20.71320515
55MAP3K30.69847938
56CLK10.67916149
57ABL10.67340030
58TESK20.66780296
59LATS20.66765239
60GRK70.65322849
61FGFR40.64946752
62BMPR20.64590049
63PIM10.63939696
64MAP3K10.61225131
65PRKG20.61189209
66MAP2K60.60399035
67TAOK30.59233627
68KSR20.59231967
69ALK0.55366972
70MST1R0.54971358
71ERBB40.54153229
72MAP2K30.53516849
73PTK60.52295258
74MST40.52177113
75FGFR30.51917105
76FYN0.51580666
77TESK10.51077944
78PAK40.49964447
79STK240.48085877
80PDPK10.48072676
81IRAK10.47562206
82MOS0.47372633
83IRAK20.47119169
84PIK3CG0.47041723
85ARAF0.46070503
86TNK20.45792807
87PKN20.45370428
88DYRK30.45025574
89LRRK20.44981705
90TEC0.43918138
91CAMKK20.43179582
92TTN0.42964827
93MAP3K100.42733186
94STK30.42117779
95RPS6KL10.41008224
96RPS6KC10.41008224
97PLK20.40832568
98MAPK40.39272322
99MAPKAPK20.39103955
100RIPK10.38669156
101PDGFRA0.38348041
102PDK10.38217858
103TRPM70.36910517
104MAP3K90.36434408
105TAOK10.36125652
106CAMK1G0.33517306
107SIK30.32074065
108RPS6KA60.31866054
109DAPK30.31034794
110TRIB30.30589040
111TAOK20.30363814
112CAMKK10.29918976
113STK40.29582672
114MAPK70.28515815
115DAPK20.27176485
116PDGFRB0.27010398
117IGF1R0.26720841
118CDK60.26219687
119HIPK20.24951004
120INSR0.23234429
121EPHA30.23111581
122PKN10.21079238
123GSK3A0.20756369
124MARK20.19928467
125SIK10.19640932
126RPS6KA20.16920180
127TGFBR10.16345450
128PDK20.15835976
129ICK0.15824063

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.90481525
2Leishmaniasis_Homo sapiens_hsa051403.78708485
3Graft-versus-host disease_Homo sapiens_hsa053323.17799851
4Legionellosis_Homo sapiens_hsa051343.07153327
5Toll-like receptor signaling pathway_Homo sapiens_hsa046203.01518073
6Malaria_Homo sapiens_hsa051442.64276827
7Pertussis_Homo sapiens_hsa051332.63399769
8Osteoclast differentiation_Homo sapiens_hsa043802.56217087
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.50458876
10NOD-like receptor signaling pathway_Homo sapiens_hsa046212.42263060
11Asthma_Homo sapiens_hsa053102.37463029
12Tuberculosis_Homo sapiens_hsa051522.31031243
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.25673758
14Rheumatoid arthritis_Homo sapiens_hsa053232.23934148
15African trypanosomiasis_Homo sapiens_hsa051432.16754665
16Allograft rejection_Homo sapiens_hsa053302.08216582
17TNF signaling pathway_Homo sapiens_hsa046682.05883757
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.05860498
19Salmonella infection_Homo sapiens_hsa051321.98573772
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.94511665
21Lysosome_Homo sapiens_hsa041421.91598728
22Type I diabetes mellitus_Homo sapiens_hsa049401.91163662
23Phagosome_Homo sapiens_hsa041451.89372545
24Measles_Homo sapiens_hsa051621.86513270
25Influenza A_Homo sapiens_hsa051641.83609639
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.73289468
27Hematopoietic cell lineage_Homo sapiens_hsa046401.59266334
28B cell receptor signaling pathway_Homo sapiens_hsa046621.55231541
29Toxoplasmosis_Homo sapiens_hsa051451.48335154
30Herpes simplex infection_Homo sapiens_hsa051681.45903165
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.44954274
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.41625950
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.37230962
34Chemokine signaling pathway_Homo sapiens_hsa040621.26728593
35Amoebiasis_Homo sapiens_hsa051461.22673881
36Antigen processing and presentation_Homo sapiens_hsa046121.19913194
37Prion diseases_Homo sapiens_hsa050201.19829982
38Shigellosis_Homo sapiens_hsa051311.17566497
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16256425
40Other glycan degradation_Homo sapiens_hsa005111.16216272
41Apoptosis_Homo sapiens_hsa042101.10666516
42Bladder cancer_Homo sapiens_hsa052191.05773006
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.05171949
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04581310
45Hepatitis B_Homo sapiens_hsa051611.04257518
46Hepatitis C_Homo sapiens_hsa051601.00153398
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96912765
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89275770
49Jak-STAT signaling pathway_Homo sapiens_hsa046300.88820351
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87444398
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86184602
52Complement and coagulation cascades_Homo sapiens_hsa046100.85828678
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82888426
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.79845589
55Adipocytokine signaling pathway_Homo sapiens_hsa049200.79073651
56Type II diabetes mellitus_Homo sapiens_hsa049300.71358538
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70369119
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67551963
59Viral myocarditis_Homo sapiens_hsa054160.67069770
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.67060601
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65566964
62T cell receptor signaling pathway_Homo sapiens_hsa046600.62580849
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62143179
64Mineral absorption_Homo sapiens_hsa049780.60346868
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56543496
66Autoimmune thyroid disease_Homo sapiens_hsa053200.55403780
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.52405028
68HIF-1 signaling pathway_Homo sapiens_hsa040660.51105928
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49162351
70Epstein-Barr virus infection_Homo sapiens_hsa051690.49125833
71Collecting duct acid secretion_Homo sapiens_hsa049660.48742681
72Platelet activation_Homo sapiens_hsa046110.46766280
73Chronic myeloid leukemia_Homo sapiens_hsa052200.46473648
74Acute myeloid leukemia_Homo sapiens_hsa052210.45510506
75Pancreatic cancer_Homo sapiens_hsa052120.42534610
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42067914
77Galactose metabolism_Homo sapiens_hsa000520.41853461
78Sulfur metabolism_Homo sapiens_hsa009200.41822807
79Prolactin signaling pathway_Homo sapiens_hsa049170.37555084
80VEGF signaling pathway_Homo sapiens_hsa043700.36889213
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36138853
82PPAR signaling pathway_Homo sapiens_hsa033200.32908487
83Insulin resistance_Homo sapiens_hsa049310.31944945
84Proteoglycans in cancer_Homo sapiens_hsa052050.26846117
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26052747
86Endocytosis_Homo sapiens_hsa041440.24764959
87Primary immunodeficiency_Homo sapiens_hsa053400.24547255
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.23943998
89Viral carcinogenesis_Homo sapiens_hsa052030.23660087
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22365963
91Steroid biosynthesis_Homo sapiens_hsa001000.22165988
92Systemic lupus erythematosus_Homo sapiens_hsa053220.20857698
93Sphingolipid metabolism_Homo sapiens_hsa006000.20498351
94Fructose and mannose metabolism_Homo sapiens_hsa000510.20134814
95Renal cell carcinoma_Homo sapiens_hsa052110.19464580
96Notch signaling pathway_Homo sapiens_hsa043300.19160252
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18766627
98Small cell lung cancer_Homo sapiens_hsa052220.18721093
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.18037977
100MAPK signaling pathway_Homo sapiens_hsa040100.18016995
101GnRH signaling pathway_Homo sapiens_hsa049120.17553371
102Dorso-ventral axis formation_Homo sapiens_hsa043200.17178638
103Synaptic vesicle cycle_Homo sapiens_hsa047210.12556665
104HTLV-I infection_Homo sapiens_hsa051660.11481318
105mTOR signaling pathway_Homo sapiens_hsa041500.11125995
106Tryptophan metabolism_Homo sapiens_hsa003800.10061075
107Vibrio cholerae infection_Homo sapiens_hsa051100.06787080
108Caffeine metabolism_Homo sapiens_hsa002320.05922442
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.05313556
110FoxO signaling pathway_Homo sapiens_hsa040680.04668809
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.04589039

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