GPR63

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a G protein-coupled receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.61190485
2locomotory exploration behavior (GO:0035641)5.58812641
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.38148053
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.26071740
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.08825521
6synaptic vesicle maturation (GO:0016188)5.03775055
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.99864756
8response to pheromone (GO:0019236)4.95033163
9positive regulation of synapse maturation (GO:0090129)4.72350433
10ionotropic glutamate receptor signaling pathway (GO:0035235)4.70018720
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.67115239
12cerebellar granule cell differentiation (GO:0021707)4.58156409
13glutamate receptor signaling pathway (GO:0007215)4.57158103
14G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.51254826
15glutamate secretion (GO:0014047)4.48779769
16layer formation in cerebral cortex (GO:0021819)4.48673076
17synaptic vesicle exocytosis (GO:0016079)4.46317743
18regulation of glutamate receptor signaling pathway (GO:1900449)4.35950481
19cerebellar Purkinje cell differentiation (GO:0021702)4.33697850
20behavioral response to nicotine (GO:0035095)4.32779358
21synaptic transmission, glutamatergic (GO:0035249)4.22514023
22exploration behavior (GO:0035640)4.21245928
23dendritic spine morphogenesis (GO:0060997)4.12921267
24regulation of synaptic vesicle exocytosis (GO:2000300)4.08191448
25regulation of synapse structural plasticity (GO:0051823)3.99598024
26chromatin remodeling at centromere (GO:0031055)3.99325215
27protein localization to synapse (GO:0035418)3.94066844
28resolution of meiotic recombination intermediates (GO:0000712)3.92723365
29regulation of long-term neuronal synaptic plasticity (GO:0048169)3.90681450
30neuronal action potential propagation (GO:0019227)3.90623449
31cellular potassium ion homeostasis (GO:0030007)3.87600162
32meiotic chromosome segregation (GO:0045132)3.85570599
33sodium ion export (GO:0071436)3.83561642
34neurotransmitter secretion (GO:0007269)3.80017651
35long-term memory (GO:0007616)3.77756135
36short-term memory (GO:0007614)3.75650124
37innervation (GO:0060384)3.75498795
38neuron cell-cell adhesion (GO:0007158)3.74356909
39neuron-neuron synaptic transmission (GO:0007270)3.74264074
40regulation of posttranscriptional gene silencing (GO:0060147)3.69903918
41regulation of gene silencing by miRNA (GO:0060964)3.69903918
42regulation of gene silencing by RNA (GO:0060966)3.69903918
43CENP-A containing nucleosome assembly (GO:0034080)3.66855260
44C4-dicarboxylate transport (GO:0015740)3.66432322
45dendrite morphogenesis (GO:0048813)3.66092617
46establishment of nucleus localization (GO:0040023)3.65386020
47DNA double-strand break processing (GO:0000729)3.65004183
48regulation of neuronal synaptic plasticity (GO:0048168)3.63544578
49membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.63395610
50regulation of excitatory postsynaptic membrane potential (GO:0060079)3.61375950
51regulation of synaptic vesicle transport (GO:1902803)3.60815536
52neurotransmitter-gated ion channel clustering (GO:0072578)3.57853264
53negative regulation of DNA-dependent DNA replication (GO:2000104)3.57464663
54gamma-aminobutyric acid transport (GO:0015812)3.54740455
55axonal fasciculation (GO:0007413)3.54286481
56retinal cone cell development (GO:0046549)3.49660976
57cell migration in hindbrain (GO:0021535)3.49559454
58cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.48545533
59regulation of synapse maturation (GO:0090128)3.47121643
60regulation of postsynaptic membrane potential (GO:0060078)3.46656911
61cell differentiation in hindbrain (GO:0021533)3.44997934
62positive regulation of membrane potential (GO:0045838)3.44718881
63neuromuscular process controlling balance (GO:0050885)3.44125527
64regulation of nuclear cell cycle DNA replication (GO:0033262)3.40011511
65regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.39501614
66regulation of centriole replication (GO:0046599)3.37758351
67DNA replication checkpoint (GO:0000076)3.33720032
68cell communication by electrical coupling (GO:0010644)3.31770289
69regulation of dendritic spine morphogenesis (GO:0061001)3.31532645
70neuron recognition (GO:0008038)3.31470094
71regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.31071312
72regulation of mitotic spindle checkpoint (GO:1903504)3.31071312
73positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.29028813
74synaptic vesicle endocytosis (GO:0048488)3.25878270
75gamma-aminobutyric acid signaling pathway (GO:0007214)3.25803432
76histone exchange (GO:0043486)3.24588460
77synapsis (GO:0007129)3.24460788
78proline transport (GO:0015824)3.21976988
79dendritic spine organization (GO:0097061)3.20596465
80membrane depolarization during action potential (GO:0086010)3.18829986
81regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.18108248
82chemosensory behavior (GO:0007635)3.17751825
83regulation of synaptic plasticity (GO:0048167)3.15993492
84somatic hypermutation of immunoglobulin genes (GO:0016446)3.15713110
85somatic diversification of immune receptors via somatic mutation (GO:0002566)3.15713110
86auditory behavior (GO:0031223)3.13258815
87replication fork processing (GO:0031297)3.11093063
88long term synaptic depression (GO:0060292)3.09639193
89mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.09192164
90behavioral defense response (GO:0002209)3.07953375
91behavioral fear response (GO:0001662)3.07953375
92positive regulation of dendritic spine morphogenesis (GO:0061003)3.05994486
93central nervous system projection neuron axonogenesis (GO:0021952)3.04487215
94synapse assembly (GO:0007416)3.01561745
95membrane depolarization (GO:0051899)3.01426867
96DNA strand elongation involved in DNA replication (GO:0006271)3.00331173
97regulation of synaptic transmission, glutamatergic (GO:0051966)3.00247700
98regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.99383721
99cochlea development (GO:0090102)2.96968911
100activation of protein kinase A activity (GO:0034199)2.94938877
101intraspecies interaction between organisms (GO:0051703)2.94839460
102social behavior (GO:0035176)2.94839460
103reciprocal meiotic recombination (GO:0007131)2.94773006
104reciprocal DNA recombination (GO:0035825)2.94773006
105postsynaptic membrane organization (GO:0001941)2.93313157
106neurotransmitter transport (GO:0006836)2.92766461
107transmission of nerve impulse (GO:0019226)2.91690762
108fear response (GO:0042596)2.91508098
109synapse organization (GO:0050808)2.90148070
110neuromuscular process (GO:0050905)2.87447232
111negative regulation of hormone biosynthetic process (GO:0032353)2.86372993
112negative regulation of hormone metabolic process (GO:0032351)2.86372993
113vesicle transport along microtubule (GO:0047496)2.85214422
114establishment of integrated proviral latency (GO:0075713)2.84510754
115DNA strand elongation (GO:0022616)2.83787067
116negative regulation of translation, ncRNA-mediated (GO:0040033)2.83591653
117regulation of translation, ncRNA-mediated (GO:0045974)2.83591653
118negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.83591653
119regulation of neurotransmitter secretion (GO:0046928)2.81762856
120regulation of neurotransmitter levels (GO:0001505)2.81375814
121membrane hyperpolarization (GO:0060081)2.81364380
122DNA replication-independent nucleosome assembly (GO:0006336)2.80317422
123DNA replication-independent nucleosome organization (GO:0034724)2.80317422
124learning (GO:0007612)2.80092265
125positive regulation of dendritic spine development (GO:0060999)2.79823487
126regulation of ARF protein signal transduction (GO:0032012)2.78606165
127long-term synaptic potentiation (GO:0060291)2.76410259
128rRNA methylation (GO:0031167)2.75923371
129positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.72981687
130organelle transport along microtubule (GO:0072384)2.72548200
131neuromuscular synaptic transmission (GO:0007274)2.71657791
132cellular sodium ion homeostasis (GO:0006883)2.70725958
133regulation of clathrin-mediated endocytosis (GO:2000369)2.70707420
134recombinational repair (GO:0000725)2.70218797
135double-strand break repair via homologous recombination (GO:0000724)2.68985763
136pseudouridine synthesis (GO:0001522)2.68462806
137prepulse inhibition (GO:0060134)2.68190398
138rRNA modification (GO:0000154)2.68151403
139positive regulation of potassium ion transmembrane transport (GO:1901381)2.67719803
140protein K6-linked ubiquitination (GO:0085020)2.66013600
141DNA unwinding involved in DNA replication (GO:0006268)2.65846781
142protein localization to kinetochore (GO:0034501)2.65829993
143mitochondrial RNA metabolic process (GO:0000959)2.65682707
144mitochondrial respiratory chain complex assembly (GO:0033108)2.65516193
145negative regulation of DNA recombination (GO:0045910)2.65045670
146regulation of centrosome cycle (GO:0046605)2.64362078
147respiratory chain complex IV assembly (GO:0008535)2.64099841
148regulation of helicase activity (GO:0051095)2.63875864
149regulation of meiosis I (GO:0060631)2.59282481
150mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.57246531
151mitochondrial respiratory chain complex I assembly (GO:0032981)2.57246531
152NADH dehydrogenase complex assembly (GO:0010257)2.57246531
153DNA replication-dependent nucleosome assembly (GO:0006335)2.56872541
154DNA replication-dependent nucleosome organization (GO:0034723)2.56872541
155maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.56672611
156DNA replication initiation (GO:0006270)2.56658320
157protein complex biogenesis (GO:0070271)2.56230606
158DNA catabolic process, exonucleolytic (GO:0000738)2.55966598
159regulation of DNA endoreduplication (GO:0032875)2.54610704
160mitotic sister chromatid segregation (GO:0000070)2.53916664
161regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.53718735
162RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.50643453
163DNA damage response, detection of DNA damage (GO:0042769)2.46189440
164retina layer formation (GO:0010842)2.45175601
165termination of RNA polymerase III transcription (GO:0006386)2.44710300
166transcription elongation from RNA polymerase III promoter (GO:0006385)2.44710300
167sister chromatid segregation (GO:0000819)2.44600289
168regulation of centrosome duplication (GO:0010824)2.43359659
169centriole replication (GO:0007099)2.42563555
170ATP synthesis coupled proton transport (GO:0015986)2.41761540
171energy coupled proton transport, down electrochemical gradient (GO:0015985)2.41761540
172water-soluble vitamin biosynthetic process (GO:0042364)2.41594226
173chromosome organization involved in meiosis (GO:0070192)2.38442392
174protein neddylation (GO:0045116)2.38159536
175ncRNA catabolic process (GO:0034661)2.37313350
176maturation of 5.8S rRNA (GO:0000460)2.36456236
177protein heterotetramerization (GO:0051290)2.36258481
178telomere maintenance via telomerase (GO:0007004)2.34985217
179purine nucleobase biosynthetic process (GO:0009113)2.34352867
180negative regulation of mitotic sister chromatid separation (GO:2000816)2.32766889
181negative regulation of sister chromatid segregation (GO:0033046)2.32766889
182negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.32766889
183negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.32766889
184negative regulation of mitotic sister chromatid segregation (GO:0033048)2.32766889
185nucleobase biosynthetic process (GO:0046112)2.32577470
186auditory receptor cell stereocilium organization (GO:0060088)2.32575684
187kinetochore organization (GO:0051383)2.32030579
188heterochromatin organization (GO:0070828)2.31061503
189IMP biosynthetic process (GO:0006188)2.30804846
190regulation of double-strand break repair via homologous recombination (GO:0010569)2.29552626
191postreplication repair (GO:0006301)2.29175470
192negative regulation of chromosome segregation (GO:0051985)2.29138401
193DNA ligation (GO:0006266)2.28849224
194isotype switching (GO:0045190)2.28433758
195somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.28433758

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.85471108
2E2F7_22180533_ChIP-Seq_HELA_Human4.98478383
3GBX2_23144817_ChIP-Seq_PC3_Human3.32413224
4MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.19469607
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.03181650
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.01920989
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97097473
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.83880565
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.83587425
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.83587425
11VDR_22108803_ChIP-Seq_LS180_Human2.82444677
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.75521403
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.72648457
14EWS_26573619_Chip-Seq_HEK293_Human2.55940118
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.47826925
16DROSHA_22980978_ChIP-Seq_HELA_Human2.46007418
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45214947
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.44689158
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.40836160
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40041787
21REST_21632747_ChIP-Seq_MESCs_Mouse2.38232432
22* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35749705
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.32339329
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.26689657
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.24865178
26EST1_17652178_ChIP-ChIP_JURKAT_Human2.24452031
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23997907
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.22315449
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20862607
30RARB_27405468_Chip-Seq_BRAIN_Mouse2.19405606
31* EZH2_27294783_Chip-Seq_ESCs_Mouse2.18708665
32* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06933579
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05900832
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05539827
35GABP_17652178_ChIP-ChIP_JURKAT_Human2.02174411
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.92750619
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.88097438
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.85641273
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83848622
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83539559
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.82881565
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.75763114
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.73857909
44MYC_18940864_ChIP-ChIP_HL60_Human1.73340898
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.73142750
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71104797
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70009718
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.69014404
49ELK1_19687146_ChIP-ChIP_HELA_Human1.67851756
50SMAD4_21799915_ChIP-Seq_A2780_Human1.64814556
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61543886
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60365383
53ZNF274_21170338_ChIP-Seq_K562_Hela1.58884304
54KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58305634
55* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58188919
56FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.56300065
57AR_21572438_ChIP-Seq_LNCaP_Human1.54180468
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52906817
59IRF1_19129219_ChIP-ChIP_H3396_Human1.47872036
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47053341
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44409788
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.43091950
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.42531319
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42520761
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40612793
66AR_19668381_ChIP-Seq_PC3_Human1.40120267
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39276109
68ETS1_20019798_ChIP-Seq_JURKAT_Human1.38956525
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37931892
70STAT3_23295773_ChIP-Seq_U87_Human1.36912824
71CREB1_15753290_ChIP-ChIP_HEK293T_Human1.35648420
72RING1B_27294783_Chip-Seq_NPCs_Mouse1.35252313
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33991600
74SOX2_16153702_ChIP-ChIP_HESCs_Human1.30359887
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30144092
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.29505200
77P300_19829295_ChIP-Seq_ESCs_Human1.29196741
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.29025917
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28585504
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28469372
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27401180
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.27360918
83WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26876910
84NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25752676
85KDM2B_26808549_Chip-Seq_K562_Human1.25122701
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.24812947
87ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24639154
88TP53_16413492_ChIP-PET_HCT116_Human1.24210037
89JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.23474053
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.23429566
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23098855
92VDR_23849224_ChIP-Seq_CD4+_Human1.22569008
93RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22133041
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19160030
95AR_25329375_ChIP-Seq_VCAP_Human1.16840699
96PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16158355
97SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16056432
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15935677
99TP63_19390658_ChIP-ChIP_HaCaT_Human1.15799542
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15612806
101FOXP3_21729870_ChIP-Seq_TREG_Human1.14742643
102YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14395726
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13422316
104TCF4_23295773_ChIP-Seq_U87_Human1.13256960
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13183500
106RNF2_27304074_Chip-Seq_NSC_Mouse1.12771463
107MYC_19030024_ChIP-ChIP_MESCs_Mouse1.12304638
108PIAS1_25552417_ChIP-Seq_VCAP_Human1.12291800
109ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11861952
110EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11657056
111TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10538708
112DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10011136
113BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09896779
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09877259
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09636720
116ER_23166858_ChIP-Seq_MCF-7_Human1.08692647
117TP53_22573176_ChIP-Seq_HFKS_Human1.08129759
118IGF1R_20145208_ChIP-Seq_DFB_Human1.08046888
119* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06658335
120PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06508877
121SMAD3_21741376_ChIP-Seq_ESCs_Human1.06122791
122NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05082671
123RXR_22108803_ChIP-Seq_LS180_Human1.04994820
124MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04885256
125NANOG_16153702_ChIP-ChIP_HESCs_Human1.04727453
126TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04559997
127FUS_26573619_Chip-Seq_HEK293_Human1.04033421
128FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03472542
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03098228
130FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02622656
131ARNT_22903824_ChIP-Seq_MCF-7_Human1.02585938
132RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02240259
133BCAT_22108803_ChIP-Seq_LS180_Human1.01310621
134* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00918535
135SMAD4_21741376_ChIP-Seq_HESCs_Human1.00617933
136HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00166243
137SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00123834
138EZH2_27294783_Chip-Seq_NPCs_Mouse0.99383933
139KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99293271
140MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99113306
141EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99007475
142NFE2_27457419_Chip-Seq_LIVER_Mouse0.98571456
143PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98405544
144TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98333164
145POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98333164
146SOX2_19829295_ChIP-Seq_ESCs_Human0.98214030
147NANOG_19829295_ChIP-Seq_ESCs_Human0.98214030
148DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97403079
149GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96263212
150SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95964627
151TCF4_22108803_ChIP-Seq_LS180_Human0.95782178
152TAF15_26573619_Chip-Seq_HEK293_Human0.95641248
153SMAD4_21741376_ChIP-Seq_EPCs_Human0.95063976
154* RUNX2_22187159_ChIP-Seq_PCA_Human0.95037238
155* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94809554
156TP53_20018659_ChIP-ChIP_R1E_Mouse0.94725090
157* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94184113
158JUN_21703547_ChIP-Seq_K562_Human0.93804205
159CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93164166
160TBX3_20139965_ChIP-Seq_ESCs_Mouse0.91340938
161TBX3_20139965_ChIP-Seq_MESCs_Mouse0.90521050
162TTF2_22483619_ChIP-Seq_HELA_Human0.89949751

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.44691222
2MP0004270_analgesia3.99487845
3MP0003635_abnormal_synaptic_transmissio3.88426447
4MP0009046_muscle_twitch3.24335351
5MP0003880_abnormal_central_pattern3.03652389
6MP0002063_abnormal_learning/memory/cond3.00882386
7MP0008877_abnormal_DNA_methylation2.94575168
8MP0009745_abnormal_behavioral_response2.79088389
9MP0008057_abnormal_DNA_replication2.73879035
10MP0003693_abnormal_embryo_hatching2.69168628
11MP0010094_abnormal_chromosome_stability2.66522653
12MP0002064_seizures2.55265598
13MP0002572_abnormal_emotion/affect_behav2.52536105
14MP0008058_abnormal_DNA_repair2.52331115
15MP0002734_abnormal_mechanical_nocicepti2.47910086
16MP0002184_abnormal_innervation2.40278445
17MP0005423_abnormal_somatic_nervous2.32334631
18MP0002272_abnormal_nervous_system2.29005964
19MP0006292_abnormal_olfactory_placode2.28595629
20MP0001968_abnormal_touch/_nociception2.26676493
21MP0001486_abnormal_startle_reflex2.14727394
22MP0006035_abnormal_mitochondrial_morpho2.10256741
23MP0008569_lethality_at_weaning2.05417866
24MP0000778_abnormal_nervous_system1.99605272
25MP0003718_maternal_effect1.98502361
26MP0004145_abnormal_muscle_electrophysio1.94801740
27MP0003111_abnormal_nucleus_morphology1.94743968
28MP0002067_abnormal_sensory_capabilities1.92678856
29MP0005645_abnormal_hypothalamus_physiol1.91750355
30MP0002735_abnormal_chemical_nociception1.89781079
31MP0001501_abnormal_sleep_pattern1.89453114
32MP0004957_abnormal_blastocyst_morpholog1.87564199
33MP0009697_abnormal_copulation1.84709013
34MP0001440_abnormal_grooming_behavior1.83838457
35MP0002557_abnormal_social/conspecific_i1.83274329
36MP0003136_yellow_coat_color1.79957295
37MP0004858_abnormal_nervous_system1.73897606
38MP0002736_abnormal_nociception_after1.73370004
39MP0004811_abnormal_neuron_physiology1.69938999
40MP0006072_abnormal_retinal_apoptosis1.68845357
41MP0005386_behavior/neurological_phenoty1.66883739
42MP0004924_abnormal_behavior1.66883739
43MP0001293_anophthalmia1.63898996
44MP0006276_abnormal_autonomic_nervous1.60103303
45MP0000955_abnormal_spinal_cord1.60093175
46MP0003879_abnormal_hair_cell1.58943964
47MP0001984_abnormal_olfaction1.55802510
48MP0002733_abnormal_thermal_nociception1.55557493
49MP0005551_abnormal_eye_electrophysiolog1.53766654
50MP0003941_abnormal_skin_development1.52234628
51MP0003787_abnormal_imprinting1.51894108
52MP0004147_increased_porphyrin_level1.51367200
53MP0005646_abnormal_pituitary_gland1.50723829
54MP0008932_abnormal_embryonic_tissue1.48527660
55MP0003122_maternal_imprinting1.46715801
56MP0001970_abnormal_pain_threshold1.46554612
57MP0003937_abnormal_limbs/digits/tail_de1.46243543
58MP0004233_abnormal_muscle_weight1.45048915
59MP0009780_abnormal_chondrocyte_physiolo1.44883648
60MP0003077_abnormal_cell_cycle1.44507220
61MP0003329_amyloid_beta_deposits1.43569721
62MP0002160_abnormal_reproductive_system1.43143662
63MP0002882_abnormal_neuron_morphology1.40132447
64MP0002066_abnormal_motor_capabilities/c1.35786826
65MP0001188_hyperpigmentation1.34233260
66MP0008872_abnormal_physiological_respon1.34011052
67MP0002938_white_spotting1.33540776
68MP0002152_abnormal_brain_morphology1.33267677
69MP0003567_abnormal_fetal_cardiomyocyte1.33245268
70MP0004885_abnormal_endolymph1.29339305
71MP0001502_abnormal_circadian_rhythm1.24754456
72MP0000751_myopathy1.22798059
73MP0003646_muscle_fatigue1.21478580
74MP0005253_abnormal_eye_physiology1.20232539
75MP0000569_abnormal_digit_pigmentation1.19165228
76MP0001299_abnormal_eye_distance/1.18254821
77MP0000049_abnormal_middle_ear1.18133349
78MP0002909_abnormal_adrenal_gland1.17462899
79MP0002638_abnormal_pupillary_reflex1.16162574
80MP0002210_abnormal_sex_determination1.15153851
81MP0004742_abnormal_vestibular_system1.13859153
82MP0005394_taste/olfaction_phenotype1.13768714
83MP0005499_abnormal_olfactory_system1.13768714
84MP0004043_abnormal_pH_regulation1.11934375
85MP0003121_genomic_imprinting1.10932846
86MP0005187_abnormal_penis_morphology1.09612904
87MP0003861_abnormal_nervous_system1.07291164
88MP0001286_abnormal_eye_development1.06118182
89MP0004133_heterotaxia1.05402796
90MP0008007_abnormal_cellular_replicative1.05046432
91MP0003283_abnormal_digestive_organ1.05039287
92MP0010386_abnormal_urinary_bladder1.04834623
93MP0003698_abnormal_male_reproductive1.03625862
94MP0003632_abnormal_nervous_system1.03013458
95MP0001919_abnormal_reproductive_system1.01839973
96MP0001929_abnormal_gametogenesis1.01527064
97MP0005389_reproductive_system_phenotype1.01492569
98MP0001529_abnormal_vocalization1.01473619
99MP0002254_reproductive_system_inflammat1.00681113
100MP0000372_irregular_coat_pigmentation1.00023329
101MP0008995_early_reproductive_senescence0.99331933
102MP0002751_abnormal_autonomic_nervous0.96796079
103MP0003786_premature_aging0.95756306
104MP0003631_nervous_system_phenotype0.95593896
105MP0003123_paternal_imprinting0.94955524
106MP0000631_abnormal_neuroendocrine_gland0.93346841
107MP0001485_abnormal_pinna_reflex0.93065838
108MP0002697_abnormal_eye_size0.91973293
109MP0004215_abnormal_myocardial_fiber0.91463880
110MP0008875_abnormal_xenobiotic_pharmacok0.91060874
111MP0002233_abnormal_nose_morphology0.90745162
112MP0002653_abnormal_ependyma_morphology0.90512399
113MP0003633_abnormal_nervous_system0.90457111
114MP0001145_abnormal_male_reproductive0.90059701
115MP0002822_catalepsy0.87475006
116MP0002102_abnormal_ear_morphology0.87348818
117MP0004085_abnormal_heartbeat0.86629783
118MP0005410_abnormal_fertilization0.85970065
119MP0000566_synostosis0.85614761
120MP0001177_atelectasis0.84987999
121MP0000653_abnormal_sex_gland0.84418734
122MP0002084_abnormal_developmental_patter0.84016211
123MP0000427_abnormal_hair_cycle0.82133635
124MP0002752_abnormal_somatic_nervous0.81180936
125MP0002085_abnormal_embryonic_tissue0.80272138
126MP0002837_dystrophic_cardiac_calcinosis0.80025687
127MP0004142_abnormal_muscle_tone0.78057478
128MP0002069_abnormal_eating/drinking_beha0.78004067
129MP0005623_abnormal_meninges_morphology0.74221030
130MP0004484_altered_response_of0.73710223
131MP0003890_abnormal_embryonic-extraembry0.72538973
132MP0003385_abnormal_body_wall0.71750859
133MP0003137_abnormal_impulse_conducting0.70533504
134MP0005248_abnormal_Harderian_gland0.67870911
135MP0000537_abnormal_urethra_morphology0.67608513
136MP0010769_abnormal_survival0.66465502
137MP0008874_decreased_physiological_sensi0.66243161
138MP0001963_abnormal_hearing_physiology0.66046586
139MP0008789_abnormal_olfactory_epithelium0.64782850
140MP0010770_preweaning_lethality0.63272419
141MP0002082_postnatal_lethality0.63272419
142MP0000534_abnormal_ureter_morphology0.62942078
143MP0010768_mortality/aging0.62192448
144MP0000733_abnormal_muscle_development0.61313665
145MP0003045_fibrosis0.60879952
146MP0002229_neurodegeneration0.59510336
147MP0008961_abnormal_basal_metabolism0.58887968
148MP0002081_perinatal_lethality0.57909655
149MP0002234_abnormal_pharynx_morphology0.57254700
150MP0002089_abnormal_postnatal_growth/wei0.56135413
151MP0000013_abnormal_adipose_tissue0.56028628
152MP0001943_abnormal_respiration0.55536883
153MP0003119_abnormal_digestive_system0.54686887

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.37288686
2Myokymia (HP:0002411)5.27616143
3Action tremor (HP:0002345)5.21246592
4Progressive cerebellar ataxia (HP:0002073)5.04614341
5Focal seizures (HP:0007359)4.63726598
6Visual hallucinations (HP:0002367)4.15435756
7Genetic anticipation (HP:0003743)3.68445704
8Epileptic encephalopathy (HP:0200134)3.61350779
9Gaze-evoked nystagmus (HP:0000640)3.37215322
10Broad-based gait (HP:0002136)3.30143285
11Atonic seizures (HP:0010819)3.26572445
12Absence seizures (HP:0002121)3.13451404
13Dysdiadochokinesis (HP:0002075)3.11886041
14Impaired smooth pursuit (HP:0007772)3.06365525
15Bilateral microphthalmos (HP:0007633)3.02799218
16Febrile seizures (HP:0002373)2.99313886
17Chromosomal breakage induced by crosslinking agents (HP:0003221)2.95843191
18Fetal akinesia sequence (HP:0001989)2.95510210
19Colon cancer (HP:0003003)2.95406809
20Chromsome breakage (HP:0040012)2.83101883
21Dysmetria (HP:0001310)2.82269405
22Dysmetric saccades (HP:0000641)2.82077231
23Meckel diverticulum (HP:0002245)2.81484180
24Poor eye contact (HP:0000817)2.80515343
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.75048559
26Progressive inability to walk (HP:0002505)2.74816530
27Abnormality of the ileum (HP:0001549)2.73039562
28Excessive salivation (HP:0003781)2.72751890
29Drooling (HP:0002307)2.72751890
30Dialeptic seizures (HP:0011146)2.71978135
31Pancreatic cysts (HP:0001737)2.70526696
32Birth length less than 3rd percentile (HP:0003561)2.68092832
33Abnormality of ocular smooth pursuit (HP:0000617)2.64154342
34Abnormality of chromosome stability (HP:0003220)2.61426710
35Abnormality of midbrain morphology (HP:0002418)2.60899335
36Molar tooth sign on MRI (HP:0002419)2.60899335
37Generalized tonic-clonic seizures (HP:0002069)2.58560888
38Pointed chin (HP:0000307)2.57414804
39Pancreatic fibrosis (HP:0100732)2.56899168
40Abnormality of the lower motor neuron (HP:0002366)2.55837237
41Scanning speech (HP:0002168)2.55017429
42Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.53503980
43Acute necrotizing encephalopathy (HP:0006965)2.51203897
44Abnormal social behavior (HP:0012433)2.49050493
45Impaired social interactions (HP:0000735)2.49050493
46Impaired vibration sensation in the lower limbs (HP:0002166)2.47881355
47Aqueductal stenosis (HP:0002410)2.46456632
48Truncal ataxia (HP:0002078)2.43559700
49True hermaphroditism (HP:0010459)2.41857401
50Depression (HP:0000716)2.40647064
51Acute encephalopathy (HP:0006846)2.34506744
52Intention tremor (HP:0002080)2.32187239
53Shallow orbits (HP:0000586)2.31408598
54Inability to walk (HP:0002540)2.31399409
55Megalencephaly (HP:0001355)2.31351276
56Insidious onset (HP:0003587)2.30295525
57Termporal pattern (HP:0011008)2.30295525
58Abnormal lung lobation (HP:0002101)2.28528137
59Oligodactyly (hands) (HP:0001180)2.28385187
60Hemiplegia (HP:0002301)2.27971597
61Nephronophthisis (HP:0000090)2.27891146
62Absent speech (HP:0001344)2.27482518
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.24421023
64Abnormality of alanine metabolism (HP:0010916)2.24421023
65Hyperalaninemia (HP:0003348)2.24421023
66Abnormal eating behavior (HP:0100738)2.23866531
67Epileptiform EEG discharges (HP:0011182)2.23828279
68Urinary bladder sphincter dysfunction (HP:0002839)2.23211473
69Supranuclear gaze palsy (HP:0000605)2.22613010
70Abnormality of binocular vision (HP:0011514)2.22245472
71Diplopia (HP:0000651)2.22245472
72Methylmalonic acidemia (HP:0002912)2.21676530
73Intestinal atresia (HP:0011100)2.20640852
74Triphalangeal thumb (HP:0001199)2.20448734
75Papilledema (HP:0001085)2.19249747
76Abnormality of the preputium (HP:0100587)2.16462590
77Optic nerve hypoplasia (HP:0000609)2.15959437
78Hemiparesis (HP:0001269)2.14274798
79Mutism (HP:0002300)2.11275260
80Small intestinal stenosis (HP:0012848)2.10616849
81Duodenal stenosis (HP:0100867)2.10616849
82Septo-optic dysplasia (HP:0100842)2.10543130
83Abnormal mitochondria in muscle tissue (HP:0008316)2.09003306
84Progressive macrocephaly (HP:0004481)2.06006413
85Pendular nystagmus (HP:0012043)2.05226226
86EEG with generalized epileptiform discharges (HP:0011198)2.04072368
87Stereotypic behavior (HP:0000733)2.02075018
88Amblyopia (HP:0000646)2.01656507
89Mitochondrial inheritance (HP:0001427)2.01234444
90Ankle clonus (HP:0011448)2.00525476
91Anxiety (HP:0000739)1.99690186
92Increased CSF lactate (HP:0002490)1.99180390
93Aplasia/Hypoplasia of the fovea (HP:0008060)1.98483845
94Hypoplasia of the fovea (HP:0007750)1.98483845
95Abnormality of the duodenum (HP:0002246)1.97489065
96Medial flaring of the eyebrow (HP:0010747)1.96212826
97Obstructive sleep apnea (HP:0002870)1.96135325
98Abnormality of homocysteine metabolism (HP:0010919)1.95465928
99Homocystinuria (HP:0002156)1.95465928
100Postural instability (HP:0002172)1.95265304
101Inappropriate behavior (HP:0000719)1.94325727
102Chronic hepatic failure (HP:0100626)1.94000283
103Agitation (HP:0000713)1.93374472
104Increased hepatocellular lipid droplets (HP:0006565)1.92776782
105Sloping forehead (HP:0000340)1.92772556
106Abnormality of the pons (HP:0007361)1.92075776
107Hypsarrhythmia (HP:0002521)1.91347962
108Torticollis (HP:0000473)1.90927411
109Abnormality of the corticospinal tract (HP:0002492)1.90228980
110Hyperventilation (HP:0002883)1.89287226
111Amyotrophic lateral sclerosis (HP:0007354)1.89167502
112Genital tract atresia (HP:0001827)1.88302850
113Nephrogenic diabetes insipidus (HP:0009806)1.88297678
114Abnormality of the carotid arteries (HP:0005344)1.88177331
115Hypoplasia of the pons (HP:0012110)1.87881058
116Supernumerary spleens (HP:0009799)1.87756255
117Ependymoma (HP:0002888)1.86220928
118Focal dystonia (HP:0004373)1.86155827
119Vaginal atresia (HP:0000148)1.85882450
120Oligodactyly (HP:0012165)1.85195510
121Sclerocornea (HP:0000647)1.84520424
122Congenital stationary night blindness (HP:0007642)1.84470545
123Lipid accumulation in hepatocytes (HP:0006561)1.84138585
124Akinesia (HP:0002304)1.84050225
125Methylmalonic aciduria (HP:0012120)1.83916461
126Neoplasm of the heart (HP:0100544)1.83882105
127Annular pancreas (HP:0001734)1.83380652
128Patellar aplasia (HP:0006443)1.81153300
129Absent septum pellucidum (HP:0001331)1.80733109
130Hyperglycinuria (HP:0003108)1.80013094
131Abnormality of serum amino acid levels (HP:0003112)1.80003102
132Abnormality of the renal medulla (HP:0100957)1.79629096
133Postural tremor (HP:0002174)1.79085075
134Incomplete penetrance (HP:0003829)1.78382390
135Lissencephaly (HP:0001339)1.77405688
136Ventricular fibrillation (HP:0001663)1.77395652
137Hyperglycinemia (HP:0002154)1.76720199
138Type II lissencephaly (HP:0007260)1.76381883
139Partial agenesis of the corpus callosum (HP:0001338)1.76157964
140Insomnia (HP:0100785)1.74695989
141Absent radius (HP:0003974)1.74585184
142Urinary urgency (HP:0000012)1.74494282
143Abnormality of the fovea (HP:0000493)1.74226725
144Abnormality of the labia minora (HP:0012880)1.73544125
145Abolished electroretinogram (ERG) (HP:0000550)1.72578253
146Abnormality of the septum pellucidum (HP:0007375)1.72181779
147Glioma (HP:0009733)1.71185960
148Absent forearm bone (HP:0003953)1.70547902
149Aplasia involving forearm bones (HP:0009822)1.70547902
150Hypoplastic nipples (HP:0002557)1.70369400
151Gastrointestinal atresia (HP:0002589)1.70226687
152Shoulder girdle muscle weakness (HP:0003547)1.68244646
153Abnormality of cochlea (HP:0000375)1.67997657
154Abnormality of salivation (HP:0100755)1.67880825
155Aplasia/Hypoplasia of the patella (HP:0006498)1.67823558
156Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.67726374
157Spastic gait (HP:0002064)1.67589489
158Congenital primary aphakia (HP:0007707)1.66990962
159Ectopic kidney (HP:0000086)1.66310738
160Absent thumb (HP:0009777)1.66268985
161Abnormality of serine family amino acid metabolism (HP:0010894)1.66177322
162Abnormality of glycine metabolism (HP:0010895)1.66177322
163Cerebral inclusion bodies (HP:0100314)1.63100838
164Anosmia (HP:0000458)1.61417099
165Papillary thyroid carcinoma (HP:0002895)1.60114408
166Horizontal nystagmus (HP:0000666)1.59853242
167Sacral dimple (HP:0000960)1.59279880
168Status epilepticus (HP:0002133)1.59038974
169Gait ataxia (HP:0002066)1.57937835
170Aplasia involving bones of the upper limbs (HP:0009823)1.57379162
171Aplasia of the phalanges of the hand (HP:0009802)1.57379162
172Aplasia involving bones of the extremities (HP:0009825)1.57379162
173Impaired vibratory sensation (HP:0002495)1.57174035
174Autism (HP:0000717)1.56042081
175Arterial tortuosity (HP:0005116)1.54848077
176Tetraplegia (HP:0002445)1.54266049
177Obsessive-compulsive behavior (HP:0000722)1.54071757
178Trigonocephaly (HP:0000243)1.53579961
179Morphological abnormality of the pyramidal tract (HP:0002062)1.52600347
180Vascular tortuosity (HP:0004948)1.51889835
181Labial hypoplasia (HP:0000066)1.49434559
182Bradykinesia (HP:0002067)1.49301494
183Macroorchidism (HP:0000053)1.48840764

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.77196690
2MAP3K93.70407462
3MAP3K43.23355409
4MARK13.14747324
5EPHA42.91533199
6ZAK2.78339610
7TTK2.74831893
8MINK12.54521776
9FRK2.47061184
10LATS22.46573417
11BUB12.41908171
12PAK62.41752694
13MKNK22.40577018
14SRPK12.37121254
15MAP2K72.30084058
16TAF12.19578137
17NTRK22.15855420
18MKNK12.15277049
19TSSK62.14499160
20WNK32.12083943
21MAP2K42.11387739
22KSR12.06865828
23NUAK12.02835220
24PRPF4B1.99369134
25PLK41.96308200
26SIK31.95010011
27TRIM281.92035638
28WEE11.89302531
29BRSK21.86995045
30KSR21.86754610
31STK381.81473336
32PRKD31.79587782
33VRK21.71701318
34CAMKK11.69434773
35SIK21.67381583
36NEK11.65494652
37LATS11.62416339
38DAPK21.59023039
39PINK11.56356996
40CHEK21.53837115
41RIPK11.53810426
42BMPR1B1.49299329
43MAPK131.47319823
44VRK11.45584924
45CAMKK21.40321705
46PLK11.35933348
47TLK11.35627130
48PBK1.35092179
49PLK21.31469547
50NEK21.27682113
51CDK51.26909574
52NTRK11.24659284
53TYRO31.24009406
54GRK11.21741292
55ADRBK21.21565058
56CSNK1G11.19513495
57CDK181.19464443
58ACVR1B1.17839190
59ATR1.15748649
60CDK151.15707971
61SCYL21.15587850
62MAP4K21.12936136
63DAPK11.12896395
64EIF2AK31.11181939
65TAOK11.10558972
66MARK21.09631135
67PRKCG1.07692623
68ALK1.05742917
69CDK141.04482107
70CDK11A0.99615285
71RET0.99295136
72DYRK20.99151366
73PNCK0.98818982
74CDK30.98134971
75MAP3K60.94939338
76MST40.93930893
77CDK190.92758772
78CAMK2A0.91303957
79STK160.90045191
80CSNK1G30.89985776
81DYRK30.87442251
82INSRR0.86320235
83STK110.85842392
84STK30.85424612
85MOS0.83903008
86WNK10.83426038
87PASK0.83021574
88OXSR10.82796465
89SGK20.82738643
90PAK30.82721492
91CAMK2B0.82179872
92CSNK1A1L0.81186156
93SGK2230.79519501
94SGK4940.79519501
95ATM0.79018270
96PRKCH0.78333813
97MAP3K120.78027547
98NME10.77921885
99WNK40.75913776
100CSNK1G20.74856585
101TAOK20.74391295
102DMPK0.73437352
103STK38L0.72643673
104RAF10.72385972
105STK390.71181486
106CAMK1G0.70966032
107SGK30.70416121
108EIF2AK10.69632276
109PHKG20.67161984
110PHKG10.67161984
111CAMK10.65784250
112EPHB20.65395663
113BMPR20.64264158
114MAP3K130.64069728
115EEF2K0.63994760
116CASK0.63101925
117RPS6KA40.62726671
118GRK50.62579466
119BRSK10.62541916
120ERBB30.62508147
121PTK2B0.61555786
122EIF2AK20.60210814
123ARAF0.59960702
124PRKCE0.59866199
125UHMK10.57025053
126FGFR20.56222284
127SGK10.56099404
128DYRK1A0.56077460
129BRD40.55062065
130AURKB0.54487126
131DDR20.54457783
132MAPK100.54256092
133MAP3K20.53632278
134CSNK1A10.50921378
135CHEK10.50753890
136CDK10.50688628
137FER0.50377112
138RPS6KA30.50365149
139RIPK40.49269928
140CCNB10.49159109
141BCR0.48293442
142PRKDC0.48285402
143PLK30.47804894
144RPS6KA50.47602339
145FYN0.46961516
146SIK10.46478890
147PTK20.44787583
148ROCK20.43551617
149MAP2K10.43501921
150CSNK1E0.43349583
151PDK10.42814875
152STK240.42389242
153MAPKAPK50.41496748
154TNIK0.40322768
155CDC70.39307967
156ERBB40.39092150
157PDGFRA0.38866757
158MAP3K70.38811173
159CSNK1D0.38651614
160CDK20.37306110
161PRKCZ0.36568008
162CAMK40.35840619
163CAMK2G0.35754823
164RPS6KB20.35525619
165CSNK2A20.33851058

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.68951900
2Long-term potentiation_Homo sapiens_hsa047202.82984696
3Glutamatergic synapse_Homo sapiens_hsa047242.71846076
4Circadian entrainment_Homo sapiens_hsa047132.68488337
5Mismatch repair_Homo sapiens_hsa034302.56201128
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.55347575
7Homologous recombination_Homo sapiens_hsa034402.52050315
8DNA replication_Homo sapiens_hsa030302.50463791
9RNA polymerase_Homo sapiens_hsa030202.49807837
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.48533790
11Synaptic vesicle cycle_Homo sapiens_hsa047212.37320258
12Non-homologous end-joining_Homo sapiens_hsa034502.35101152
13GABAergic synapse_Homo sapiens_hsa047272.30789782
14Amphetamine addiction_Homo sapiens_hsa050312.29869619
15Olfactory transduction_Homo sapiens_hsa047402.29706055
16Fanconi anemia pathway_Homo sapiens_hsa034602.29174705
17Nitrogen metabolism_Homo sapiens_hsa009102.15863791
18Morphine addiction_Homo sapiens_hsa050322.15746383
19Salivary secretion_Homo sapiens_hsa049702.14371055
20Basal transcription factors_Homo sapiens_hsa030222.10970773
21Dopaminergic synapse_Homo sapiens_hsa047282.08061071
22Long-term depression_Homo sapiens_hsa047302.04330729
23Oxidative phosphorylation_Homo sapiens_hsa001902.02385733
24Protein export_Homo sapiens_hsa030601.96873236
25One carbon pool by folate_Homo sapiens_hsa006701.94131797
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.91542717
27Selenocompound metabolism_Homo sapiens_hsa004501.90339902
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.89920384
29Parkinsons disease_Homo sapiens_hsa050121.88066118
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85824072
31Insulin secretion_Homo sapiens_hsa049111.85588676
32Cholinergic synapse_Homo sapiens_hsa047251.81797853
33Proteasome_Homo sapiens_hsa030501.78559218
34Gastric acid secretion_Homo sapiens_hsa049711.70931571
35RNA transport_Homo sapiens_hsa030131.70884350
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70649099
37Taste transduction_Homo sapiens_hsa047421.68696082
38Oxytocin signaling pathway_Homo sapiens_hsa049211.68165317
39RNA degradation_Homo sapiens_hsa030181.65427264
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63902558
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.62095799
42Phototransduction_Homo sapiens_hsa047441.61369617
43GnRH signaling pathway_Homo sapiens_hsa049121.56149246
44Huntingtons disease_Homo sapiens_hsa050161.55425013
45Serotonergic synapse_Homo sapiens_hsa047261.53460066
46Spliceosome_Homo sapiens_hsa030401.52867240
47Renin secretion_Homo sapiens_hsa049241.51851849
48Propanoate metabolism_Homo sapiens_hsa006401.51721696
49Calcium signaling pathway_Homo sapiens_hsa040201.49338798
50Cell cycle_Homo sapiens_hsa041101.46637923
51Axon guidance_Homo sapiens_hsa043601.44519034
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43861407
53Cocaine addiction_Homo sapiens_hsa050301.42707700
54Gap junction_Homo sapiens_hsa045401.41571957
55Type II diabetes mellitus_Homo sapiens_hsa049301.41223099
56Nucleotide excision repair_Homo sapiens_hsa034201.36798524
57Estrogen signaling pathway_Homo sapiens_hsa049151.32604304
58cAMP signaling pathway_Homo sapiens_hsa040241.31275147
59Alzheimers disease_Homo sapiens_hsa050101.27891454
60Oocyte meiosis_Homo sapiens_hsa041141.27098242
61Base excision repair_Homo sapiens_hsa034101.26666090
62Phosphatidylinositol signaling system_Homo sapiens_hsa040701.26472454
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25572919
64Glioma_Homo sapiens_hsa052141.25545651
65Butanoate metabolism_Homo sapiens_hsa006501.21813015
66Melanogenesis_Homo sapiens_hsa049161.17541376
67ErbB signaling pathway_Homo sapiens_hsa040121.16602414
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16019100
69cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13596895
70Pyrimidine metabolism_Homo sapiens_hsa002401.10287732
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09718431
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07368949
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06197413
74Ribosome_Homo sapiens_hsa030101.05931439
75Dilated cardiomyopathy_Homo sapiens_hsa054141.05230841
76Purine metabolism_Homo sapiens_hsa002301.04842559
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04449725
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04426680
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02592727
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97977879
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96559912
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.94230720
83mTOR signaling pathway_Homo sapiens_hsa041500.92643222
84Pyruvate metabolism_Homo sapiens_hsa006200.92455545
85Choline metabolism in cancer_Homo sapiens_hsa052310.91813777
86Thyroid hormone synthesis_Homo sapiens_hsa049180.91620274
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91186359
88Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89953976
89Steroid biosynthesis_Homo sapiens_hsa001000.89016404
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.88871356
91Fatty acid elongation_Homo sapiens_hsa000620.87642057
92MAPK signaling pathway_Homo sapiens_hsa040100.86851248
93Pancreatic secretion_Homo sapiens_hsa049720.86729590
94Dorso-ventral axis formation_Homo sapiens_hsa043200.85787825
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.85558925
96Wnt signaling pathway_Homo sapiens_hsa043100.83200663
97Circadian rhythm_Homo sapiens_hsa047100.83186217
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82510420
99VEGF signaling pathway_Homo sapiens_hsa043700.81962857
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81899019
101Ether lipid metabolism_Homo sapiens_hsa005650.80631006
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80572805
103Caffeine metabolism_Homo sapiens_hsa002320.79883240
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79485471
105Endometrial cancer_Homo sapiens_hsa052130.78860684
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78551487
107Linoleic acid metabolism_Homo sapiens_hsa005910.77193047
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76853576
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.76266240
110Hippo signaling pathway_Homo sapiens_hsa043900.76044446
111mRNA surveillance pathway_Homo sapiens_hsa030150.75935635
112Hedgehog signaling pathway_Homo sapiens_hsa043400.73943250
113Colorectal cancer_Homo sapiens_hsa052100.69832161
114Rap1 signaling pathway_Homo sapiens_hsa040150.69529017
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69387653
116Renal cell carcinoma_Homo sapiens_hsa052110.69217500
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69105067
118Ovarian steroidogenesis_Homo sapiens_hsa049130.68627930
119Ras signaling pathway_Homo sapiens_hsa040140.67827922
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67754250
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67633891
122Non-small cell lung cancer_Homo sapiens_hsa052230.67314969
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66560878
124p53 signaling pathway_Homo sapiens_hsa041150.64254566
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63325880
126Glucagon signaling pathway_Homo sapiens_hsa049220.62792335
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58308711
128Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58131747
129Proteoglycans in cancer_Homo sapiens_hsa052050.56033006
130Vitamin B6 metabolism_Homo sapiens_hsa007500.56018100
131Cardiac muscle contraction_Homo sapiens_hsa042600.55912260
132Metabolic pathways_Homo sapiens_hsa011000.55864134
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55812778
134Basal cell carcinoma_Homo sapiens_hsa052170.54966699
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53919370
136Sulfur relay system_Homo sapiens_hsa041220.52577595
137Alcoholism_Homo sapiens_hsa050340.50895304
138Inositol phosphate metabolism_Homo sapiens_hsa005620.50519887
139Sphingolipid signaling pathway_Homo sapiens_hsa040710.50130700
140Tryptophan metabolism_Homo sapiens_hsa003800.48969872
141Retinol metabolism_Homo sapiens_hsa008300.47950554
142Tight junction_Homo sapiens_hsa045300.45878877
143Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45637221
144Biosynthesis of amino acids_Homo sapiens_hsa012300.45495414
145Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45187521
146Insulin signaling pathway_Homo sapiens_hsa049100.45065734
147Pancreatic cancer_Homo sapiens_hsa052120.44253924
148Maturity onset diabetes of the young_Homo sapiens_hsa049500.43749090
149Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43423421
150Glycerolipid metabolism_Homo sapiens_hsa005610.42653257
151Endocytosis_Homo sapiens_hsa041440.42606930
152beta-Alanine metabolism_Homo sapiens_hsa004100.42283428
153Bile secretion_Homo sapiens_hsa049760.41602525
154Lysine degradation_Homo sapiens_hsa003100.41539032
155MicroRNAs in cancer_Homo sapiens_hsa052060.41465840
156Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40830452
157Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40798023
158TGF-beta signaling pathway_Homo sapiens_hsa043500.40494569
159Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39486483
160Melanoma_Homo sapiens_hsa052180.39451886
161Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38108797
162Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37774816
163FoxO signaling pathway_Homo sapiens_hsa040680.37313716
164Prolactin signaling pathway_Homo sapiens_hsa049170.37178380
165Arginine and proline metabolism_Homo sapiens_hsa003300.37002694
166Peroxisome_Homo sapiens_hsa041460.36795176
167Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36754311
168Vitamin digestion and absorption_Homo sapiens_hsa049770.35878085
169Focal adhesion_Homo sapiens_hsa045100.35830057
170Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35796628
171Folate biosynthesis_Homo sapiens_hsa007900.34952534

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