GPR45

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ER overload response (GO:0006983)6.15139212
2signal peptide processing (GO:0006465)5.93891865
3Golgi transport vesicle coating (GO:0048200)5.47347507
4COPI coating of Golgi vesicle (GO:0048205)5.47347507
5endocrine pancreas development (GO:0031018)4.41308802
6presynaptic membrane assembly (GO:0097105)4.40928157
7intraciliary transport (GO:0042073)4.23044686
8insulin secretion (GO:0030073)4.04348828
9protein maturation by protein folding (GO:0022417)3.97824306
10neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.92867504
11urinary tract smooth muscle contraction (GO:0014848)3.89834127
12negative regulation of dendrite morphogenesis (GO:0050774)3.82280088
13regulation of glucokinase activity (GO:0033131)3.81062610
14regulation of hexokinase activity (GO:1903299)3.81062610
15protein localization to cilium (GO:0061512)3.78742103
16postsynaptic membrane organization (GO:0001941)3.77508338
17detection of calcium ion (GO:0005513)3.69356450
18presynaptic membrane organization (GO:0097090)3.68257825
19intra-Golgi vesicle-mediated transport (GO:0006891)3.56893405
20retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.56370717
21maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.54896774
22glandular epithelial cell differentiation (GO:0002067)3.43797669
23cellular response to ATP (GO:0071318)3.43713156
24regulation of insulin secretion (GO:0050796)3.40860892
25interleukin-1-mediated signaling pathway (GO:0070498)3.36395903
26nucleotide transmembrane transport (GO:1901679)3.33719304
27peripheral nervous system neuron development (GO:0048935)3.32340049
28peptide hormone processing (GO:0016486)3.31826005
29nerve growth factor signaling pathway (GO:0038180)3.31546166
30lactate metabolic process (GO:0006089)3.27915565
31positive regulation of steroid hormone secretion (GO:2000833)3.27288756
32regulation of glucocorticoid secretion (GO:2000849)3.16370027
33negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.15441463
34regulation of peptide hormone secretion (GO:0090276)3.15257878
35sequestering of metal ion (GO:0051238)3.12927655
36regulation of peptide secretion (GO:0002791)3.12475101
37positive regulation of insulin secretion (GO:0032024)3.07354670
38negative regulation of norepinephrine secretion (GO:0010700)3.05053543
39negative regulation of glycogen biosynthetic process (GO:0045719)3.03850339
40organelle disassembly (GO:1903008)3.01204103
41regulation of synaptic vesicle exocytosis (GO:2000300)3.00797087
42regulation of type B pancreatic cell apoptotic process (GO:2000674)3.00633527
43neuronal action potential propagation (GO:0019227)2.99987981
44inositol phosphate catabolic process (GO:0071545)2.96667146
45viral protein processing (GO:0019082)2.96392453
46negative regulation of calcium ion transport into cytosol (GO:0010523)2.92331888
47regulation of hormone secretion (GO:0046883)2.91603961
48negative regulation of insulin secretion (GO:0046676)2.88816011
49neuron fate specification (GO:0048665)2.87997994
50positive regulation of mitochondrial fission (GO:0090141)2.87473759
51COPII vesicle coating (GO:0048208)2.86588097
52neuronal action potential (GO:0019228)2.86547700
53ribonucleoprotein complex disassembly (GO:0032988)2.85451935
54purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.83934685
553-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.83934685
56innervation (GO:0060384)2.82618033
57protein retention in ER lumen (GO:0006621)2.81930552
58regulation of autophagic vacuole assembly (GO:2000785)2.80396024
59negative regulation of activin receptor signaling pathway (GO:0032926)2.76726757
60regulation of corticosteroid hormone secretion (GO:2000846)2.75189020
61positive regulation of action potential (GO:0045760)2.75031773
62metanephric mesenchyme development (GO:0072075)2.74711240
63response to redox state (GO:0051775)2.74302710
64negative regulation of heart rate (GO:0010459)2.69730637
65regulation of synaptic vesicle transport (GO:1902803)2.67346127
66negative regulation of catecholamine secretion (GO:0033604)2.66576239
67dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.65779779
68regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.65746040
69peptidyl-histidine modification (GO:0018202)2.64831592
70cranial nerve development (GO:0021545)2.63041974
71negative regulation of glycogen metabolic process (GO:0070874)2.60559439
72cell differentiation involved in metanephros development (GO:0072202)2.59500312
73peptide hormone secretion (GO:0030072)2.59336337
74regulation of neuron projection regeneration (GO:0070570)2.58030634
75regulation of axon regeneration (GO:0048679)2.58030634
76regulation of oxidative phosphorylation (GO:0002082)2.57436770
77inner ear receptor cell development (GO:0060119)2.56907701
78calcium ion-dependent exocytosis (GO:0017156)2.56777541
79activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.55710230
80negative regulation of dendrite development (GO:2000171)2.55631545
81negative regulation of exocytosis (GO:0045920)2.54611671
82vesicle coating (GO:0006901)2.54046526
83behavioral response to ethanol (GO:0048149)2.53738025
84mannosylation (GO:0097502)2.53325489
85protein localization to Golgi apparatus (GO:0034067)2.53132066
86cellular response to hepatocyte growth factor stimulus (GO:0035729)2.53079196
87response to hepatocyte growth factor (GO:0035728)2.53079196
88regulation of vesicle fusion (GO:0031338)2.52451686
89negative regulation of peptide hormone secretion (GO:0090278)2.52130202
90neuron cell-cell adhesion (GO:0007158)2.50843913
91somite development (GO:0061053)2.48953504
92chemosensory behavior (GO:0007635)2.47771403
93positive regulation of peptide secretion (GO:0002793)2.47316079
94peptide secretion (GO:0002790)2.46940336
95kidney mesenchyme development (GO:0072074)2.46089733
96positive regulation of peptide hormone secretion (GO:0090277)2.45760191
97regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.45077843
98ER to Golgi vesicle-mediated transport (GO:0006888)2.45014802
99regulation of peptide transport (GO:0090087)2.43329505
100negative regulation of bone resorption (GO:0045779)2.43214421

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.30261680
2GBX2_23144817_ChIP-Seq_PC3_Human4.20981237
3IGF1R_20145208_ChIP-Seq_DFB_Human2.83376446
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.70625230
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.54706013
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.45471910
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.32208727
8BMI1_23680149_ChIP-Seq_NPCS_Mouse2.25189650
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.22459848
10REST_21632747_ChIP-Seq_MESCs_Mouse2.09084329
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.01265009
12PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.95542127
13VDR_22108803_ChIP-Seq_LS180_Human1.93301793
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.90472740
15P300_19829295_ChIP-Seq_ESCs_Human1.84581687
16PIAS1_25552417_ChIP-Seq_VCAP_Human1.82343768
17* RBPJ_22232070_ChIP-Seq_NCS_Mouse1.80662772
18SMAD4_21799915_ChIP-Seq_A2780_Human1.80474613
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.79236283
20TAF15_26573619_Chip-Seq_HEK293_Human1.76620283
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72090617
22STAT3_23295773_ChIP-Seq_U87_Human1.69320853
23* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68192332
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67702320
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.67667688
26OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66516138
27MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.65260695
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62175622
29RNF2_27304074_Chip-Seq_NSC_Mouse1.61956463
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61453619
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61347753
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.61100974
33* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.60058342
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58948150
35NR3C1_23031785_ChIP-Seq_PC12_Mouse1.57585934
36* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.55761650
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55706390
38* FLI1_27457419_Chip-Seq_LIVER_Mouse1.51945493
39* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51509191
40* EZH2_27294783_Chip-Seq_ESCs_Mouse1.50079515
41DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.48295542
42* NANOG_18555785_Chip-Seq_ESCs_Mouse1.47935857
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45045971
44FUS_26573619_Chip-Seq_HEK293_Human1.44815125
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.42819835
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40264726
47* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.39879135
48* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39683876
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39089186
50* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37259792
51REST_18959480_ChIP-ChIP_MESCs_Mouse1.36989514
52* P53_22387025_ChIP-Seq_ESCs_Mouse1.33872627
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.33385384
54TCF4_23295773_ChIP-Seq_U87_Human1.32770084
55RNF2_27304074_Chip-Seq_ESCs_Mouse1.31931364
56* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31453501
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.30460301
58* STAT3_18555785_Chip-Seq_ESCs_Mouse1.29077675
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27105869
60RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27105869
61* CMYC_18555785_Chip-Seq_ESCs_Mouse1.26692259
62SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.25097443
63AR_25329375_ChIP-Seq_VCAP_Human1.24041274
64RARB_27405468_Chip-Seq_BRAIN_Mouse1.24000527
65* E2F1_18555785_Chip-Seq_ESCs_Mouse1.23626595
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23533240
67* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22772341
68RUNX2_22187159_ChIP-Seq_PCA_Human1.21787005
69SOX2_21211035_ChIP-Seq_LN229_Gbm1.20367507
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19868860
71EWS_26573619_Chip-Seq_HEK293_Human1.19089726
72FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17910250
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17140359
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17078226
75* NMYC_18555785_Chip-Seq_ESCs_Mouse1.16843036
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.14737737
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14564938
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14564938
79* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14318463
80RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11962759
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11438846
82* P300_18555785_Chip-Seq_ESCs_Mouse1.11018876
83* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10127726
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09970814
85ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09162700
86* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08522180
87ER_23166858_ChIP-Seq_MCF-7_Human1.08325920
88YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06908122
89TAL1_26923725_Chip-Seq_HPCs_Mouse1.06280350
90* SOX2_18555785_Chip-Seq_ESCs_Mouse1.05867154
91* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05333223
92SOX2_19829295_ChIP-Seq_ESCs_Human1.05197873
93NANOG_19829295_ChIP-Seq_ESCs_Human1.05197873
94WT1_19549856_ChIP-ChIP_CCG9911_Human1.05022831
95JUN_21703547_ChIP-Seq_K562_Human1.04909247
96* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04864433
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04164344
98* KDM2B_26808549_Chip-Seq_REH_Human1.03769044
99* ARNT_22903824_ChIP-Seq_MCF-7_Human1.03613287
100P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03533591

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity4.01670357
2MP0010386_abnormal_urinary_bladder3.65691607
3MP0004043_abnormal_pH_regulation3.52688819
4MP0002877_abnormal_melanocyte_morpholog3.34578667
5MP0004270_analgesia3.29968687
6MP0002735_abnormal_chemical_nociception3.21680132
7MP0002876_abnormal_thyroid_physiology2.72039768
8MP0001188_hyperpigmentation2.69528937
9MP0009780_abnormal_chondrocyte_physiolo2.61525041
10MP0000678_abnormal_parathyroid_gland2.47990644
11MP0005646_abnormal_pituitary_gland2.46239495
12MP0002693_abnormal_pancreas_physiology2.43816838
13MP0004859_abnormal_synaptic_plasticity2.41972620
14MP0002909_abnormal_adrenal_gland2.31499043
15MP0001968_abnormal_touch/_nociception2.25015809
16MP0002734_abnormal_mechanical_nocicepti2.23770894
17MP0005379_endocrine/exocrine_gland_phen2.21912980
18MP0001944_abnormal_pancreas_morphology2.21004147
19MP0006276_abnormal_autonomic_nervous2.18986010
20MP0003183_abnormal_peptide_metabolism2.16420223
21MP0000015_abnormal_ear_pigmentation2.12819775
22MP0003880_abnormal_central_pattern2.09601611
23MP0006072_abnormal_retinal_apoptosis2.01258108
24MP0005645_abnormal_hypothalamus_physiol1.94988249
25MP0003635_abnormal_synaptic_transmissio1.93129834
26MP0002837_dystrophic_cardiac_calcinosis1.78432541
27MP0003122_maternal_imprinting1.75089843
28MP0002272_abnormal_nervous_system1.73668218
29MP0002733_abnormal_thermal_nociception1.73151967
30MP0003195_calcinosis1.71324429
31MP0002751_abnormal_autonomic_nervous1.71263456
32MP0006292_abnormal_olfactory_placode1.68934107
33MP0000013_abnormal_adipose_tissue1.67870075
34MP0005171_absent_coat_pigmentation1.67788290
35MP0002736_abnormal_nociception_after1.64314745
36MP0002063_abnormal_learning/memory/cond1.63597745
37MP0002638_abnormal_pupillary_reflex1.62735887
38MP0009745_abnormal_behavioral_response1.59831569
39MP0003283_abnormal_digestive_organ1.58021426
40MP0001970_abnormal_pain_threshold1.56365767
41MP0002572_abnormal_emotion/affect_behav1.56168471
42MP0002184_abnormal_innervation1.51252110
43MP0001984_abnormal_olfaction1.49101852
44MP0000681_abnormal_thyroid_gland1.41491508
45MP0002064_seizures1.37066331
46MP0005409_darkened_coat_color1.37056343
47MP0000631_abnormal_neuroendocrine_gland1.36510433
48MP0000778_abnormal_nervous_system1.34688279
49MP0002078_abnormal_glucose_homeostasis1.34003149
50MP0002067_abnormal_sensory_capabilities1.33705326
51MP0001905_abnormal_dopamine_level1.27966459
52MP0000955_abnormal_spinal_cord1.27245264
53MP0002557_abnormal_social/conspecific_i1.21527136
54MP0004858_abnormal_nervous_system1.19747087
55MP0004142_abnormal_muscle_tone1.18551973
56MP0008569_lethality_at_weaning1.15865917
57MP0000372_irregular_coat_pigmentation1.14852058
58MP0003879_abnormal_hair_cell1.14352351
59MP0003787_abnormal_imprinting1.13539021
60MP0001502_abnormal_circadian_rhythm1.12666506
61MP0001501_abnormal_sleep_pattern1.11928621
62MP0003890_abnormal_embryonic-extraembry1.07745812
63MP0005253_abnormal_eye_physiology1.06449367
64MP0005220_abnormal_exocrine_pancreas1.05840432
65MP0005423_abnormal_somatic_nervous1.05237877
66MP0002229_neurodegeneration1.03851933
67MP0002882_abnormal_neuron_morphology1.02936594
68MP0005535_abnormal_body_temperature1.00964940
69MP0000538_abnormal_urinary_bladder0.96423457
70MP0004811_abnormal_neuron_physiology0.95171657
71MP0002163_abnormal_gland_morphology0.92366842
72MP0003953_abnormal_hormone_level0.92225049
73MP0004085_abnormal_heartbeat0.91859532
74MP0009046_muscle_twitch0.90573702
75MP0003136_yellow_coat_color0.90213735
76MP0001486_abnormal_startle_reflex0.88511403
77MP0000566_synostosis0.87284111
78MP0001919_abnormal_reproductive_system0.84824950
79MP0001299_abnormal_eye_distance/0.83469535
80MP0001765_abnormal_ion_homeostasis0.82189915
81MP0008260_abnormal_autophagy0.81369847
82MP0003634_abnormal_glial_cell0.81331843
83MP0002066_abnormal_motor_capabilities/c0.80705808
84MP0002177_abnormal_outer_ear0.80168165
85MP0005310_abnormal_salivary_gland0.80127584
86MP0001186_pigmentation_phenotype0.79889357
87MP0001485_abnormal_pinna_reflex0.79782905
88MP0001963_abnormal_hearing_physiology0.79401583
89MP0004924_abnormal_behavior0.79344299
90MP0005386_behavior/neurological_phenoty0.79344299
91MP0002069_abnormal_eating/drinking_beha0.77714235
92MP0003633_abnormal_nervous_system0.77199084
93MP0005408_hypopigmentation0.77117055
94MP0001664_abnormal_digestion0.74684900
95MP0005551_abnormal_eye_electrophysiolog0.74462730
96MP0003172_abnormal_lysosome_physiology0.73376163
97MP0003868_abnormal_feces_composition0.73231786
98MP0005389_reproductive_system_phenotype0.72140398
99MP0002938_white_spotting0.69518020
100MP0000230_abnormal_systemic_arterial0.69258406

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)5.09831724
2Hyperinsulinemic hypoglycemia (HP:0000825)4.56654588
3Type I transferrin isoform profile (HP:0003642)4.35564389
4Hypoglycemic seizures (HP:0002173)4.16614831
5Symptomatic seizures (HP:0011145)4.15549278
6Decreased circulating renin level (HP:0003351)4.02681637
7Focal motor seizures (HP:0011153)3.68612921
8Aplasia/Hypoplasia of the fovea (HP:0008060)3.46688303
9Hypoplasia of the fovea (HP:0007750)3.46688303
10Abnormal protein glycosylation (HP:0012346)3.46049751
11Abnormal glycosylation (HP:0012345)3.46049751
12Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.46049751
13Abnormal protein N-linked glycosylation (HP:0012347)3.46049751
14Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.28380820
15Medial flaring of the eyebrow (HP:0010747)3.21524494
16Intestinal atresia (HP:0011100)3.13180701
17Reduced antithrombin III activity (HP:0001976)3.10300780
18Abnormality of the fovea (HP:0000493)3.06717405
19Gait imbalance (HP:0002141)3.02612213
20True hermaphroditism (HP:0010459)2.95839141
21Hypoglycemic coma (HP:0001325)2.89100288
22Congenital primary aphakia (HP:0007707)2.88692866
23Conjugated hyperbilirubinemia (HP:0002908)2.85267965
24Osteomalacia (HP:0002749)2.80634977
25Abnormal pancreas size (HP:0012094)2.79563631
26Nephrogenic diabetes insipidus (HP:0009806)2.75572499
27Hyperglycemia (HP:0003074)2.74599490
28Absent eyebrow (HP:0002223)2.74424464
29Hypokalemia (HP:0002900)2.73555652
30Pancreatic fibrosis (HP:0100732)2.68021116
31Abnormality of calcium-phosphate metabolism (HP:0100530)2.59930091
32Molar tooth sign on MRI (HP:0002419)2.59553681
33Abnormality of midbrain morphology (HP:0002418)2.59553681
34Generalized aminoaciduria (HP:0002909)2.55875786
35Abnormal hair whorl (HP:0010721)2.55424015
36Genital tract atresia (HP:0001827)2.50401273
37Vaginal atresia (HP:0000148)2.47868720
38Insulin-resistant diabetes mellitus (HP:0000831)2.46425637
39Dysautonomia (HP:0002459)2.45116648
40Bradycardia (HP:0001662)2.41648002
41Visual hallucinations (HP:0002367)2.40848049
42Exotropia (HP:0000577)2.38136200
43Tubulointerstitial nephritis (HP:0001970)2.38129814
44Poor coordination (HP:0002370)2.28741728
45Atonic seizures (HP:0010819)2.26231018
46Epileptiform EEG discharges (HP:0011182)2.25684362
47Abnormality of renin-angiotensin system (HP:0000847)2.25176904
48Pancreatic islet-cell hyperplasia (HP:0004510)2.24596615
49Hypomagnesemia (HP:0002917)2.24402976
50Hyperkalemia (HP:0002153)2.23981281
51EEG with generalized epileptiform discharges (HP:0011198)2.23646656
52Abnormality of potassium homeostasis (HP:0011042)2.23195807
53Cystic liver disease (HP:0006706)2.22041328
54Abnormality of magnesium homeostasis (HP:0004921)2.21546265
55Epileptic encephalopathy (HP:0200134)2.20210170
56Hyperactive renin-angiotensin system (HP:0000841)2.18698111
57Pheochromocytoma (HP:0002666)2.18535306
58Agitation (HP:0000713)2.15058734
59Febrile seizures (HP:0002373)2.14560629
60Bifid tongue (HP:0010297)2.14241894
61Disproportionate short-trunk short stature (HP:0003521)2.13563659
62Hypsarrhythmia (HP:0002521)2.12810479
63Pancreatic cysts (HP:0001737)2.11759790
64Aplasia/Hypoplasia of the macula (HP:0008059)2.09544773
65Abnormality of endocrine pancreas physiology (HP:0012093)2.08835078
66Abnormality of the pancreatic islet cells (HP:0006476)2.08835078
67Occipital encephalocele (HP:0002085)2.07772366
68Congenital sensorineural hearing impairment (HP:0008527)2.06341179
69Neuroendocrine neoplasm (HP:0100634)2.03901374
70Myokymia (HP:0002411)2.02574867
71Hepatoblastoma (HP:0002884)2.01758790
72Hyperventilation (HP:0002883)2.01724577
73Cutaneous finger syndactyly (HP:0010554)2.01197247
74Aplasia/Hypoplasia of the lens (HP:0008063)1.95553418
75Chronic hepatic failure (HP:0100626)1.95268495
76Cortical visual impairment (HP:0100704)1.89906905
77Poor suck (HP:0002033)1.88526414
78Abnormality of the intrinsic pathway (HP:0010989)1.86198064
79Menstrual irregularities (HP:0000858)1.85466971
80Blue irides (HP:0000635)1.84001206
81Papillary thyroid carcinoma (HP:0002895)1.83872384
82Aplasia/Hypoplasia affecting the retina (HP:0008061)1.83789765
83Renal cortical cysts (HP:0000803)1.82843944
84Protruding tongue (HP:0010808)1.81486975
85Unilateral renal agenesis (HP:0000122)1.81177054
86Nephronophthisis (HP:0000090)1.79712981
87Abnormal autonomic nervous system physiology (HP:0012332)1.79032818
88Thyroid carcinoma (HP:0002890)1.75372718
89Cutaneous syndactyly (HP:0012725)1.72442989
90Methylmalonic acidemia (HP:0002912)1.69692308
91Dialeptic seizures (HP:0011146)1.69346522
92Progressive macrocephaly (HP:0004481)1.69162487
93Submucous cleft hard palate (HP:0000176)1.68207417
94Poor speech (HP:0002465)1.67987104
95Acute necrotizing encephalopathy (HP:0006965)1.67333224
96Oligomenorrhea (HP:0000876)1.67318955
97Failure to thrive in infancy (HP:0001531)1.67286875
98Absent eyelashes (HP:0000561)1.67003145
99Ketoacidosis (HP:0001993)1.66863098
100Limb hypertonia (HP:0002509)1.66705277

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.52667337
2PRPF4B3.51636852
3CASK3.48567951
4EPHA33.05679983
5AKT33.03403327
6PRKD32.94183905
7NTRK32.69961894
8SIK32.64970330
9MAP3K22.34665714
10CAMKK22.19697387
11MAPK152.17056962
12FRK2.15912960
13PASK2.10725323
14SGK22.07326035
15BMPR1B1.96960559
16BMPR21.92774969
17MAPK131.87624201
18BRD41.79948981
19IRAK31.73241539
20SGK4941.68045759
21SGK2231.68045759
22IRAK11.63669980
23BCR1.61807867
24ERBB31.55592958
25CDC42BPA1.49009540
26MAP2K71.42020749
27STK161.34131762
28HIPK21.29468983
29RPS6KA21.22141648
30YES11.20477161
31WNK41.19208623
32PLK21.15890817
33PRKD21.14372716
34MINK11.14348361
35ADRBK21.13764413
36ZAK1.09732679
37SGK31.07791459
38PRKCE1.06379829
39MARK11.05838302
40BRSK21.00459098
41STK38L0.99716896
42EPHA40.94613164
43PRKCH0.89961331
44NME10.88808824
45BRAF0.88408708
46IRAK40.84496222
47MAP3K40.82804161
48KSR10.82458407
49STK240.82177334
50IRAK20.81506108
51RPS6KB10.81426396
52TNIK0.79588334
53CDK30.77188656
54CAMK2B0.76466949
55DYRK20.75543644
56NEK60.73306399
57RIPK40.73204785
58WNK30.71550689
59WNK10.69733953
60MAP3K120.69079303
61PRKCG0.67613740
62GRK70.65133649
63GRK50.64638936
64NTRK10.63603877
65CAMK2A0.63504735
66EIF2AK30.61739203
67CAMK2D0.61663394
68TAOK20.61255964
69UHMK10.59319947
70CAMKK10.57368252
71MAP3K140.55365308
72NUAK10.54855862
73MUSK0.51719874
74MKNK20.51608180
75ARAF0.50112245
76ADRBK10.49195045
77LIMK10.48614135
78TNK20.47690622
79CDK50.46154642
80BRSK10.46099877
81PINK10.45389316
82CSNK1A10.43928016
83PRKG10.43159440
84MAP2K40.42135858
85VRK10.41910974
86RPS6KL10.38059431
87RPS6KC10.38059431
88SGK10.37285101
89NLK0.35809184
90CAMK2G0.35403125
91PRKACA0.33933490
92FER0.33718825
93PRKG20.33535788
94PLK30.33211401
95CSNK1G30.32166196
96MAP2K10.31479015
97CSNK1G20.31278641
98MAP3K10.31200436
99DYRK1A0.31062224
100RPS6KA60.28373881

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.85995710
2Protein export_Homo sapiens_hsa030605.74821641
3Insulin secretion_Homo sapiens_hsa049113.10665728
4Sulfur metabolism_Homo sapiens_hsa009203.05727888
5Taste transduction_Homo sapiens_hsa047422.21354759
6Amphetamine addiction_Homo sapiens_hsa050312.20565594
7Vibrio cholerae infection_Homo sapiens_hsa051101.93892945
8Serotonergic synapse_Homo sapiens_hsa047261.92083817
9Long-term potentiation_Homo sapiens_hsa047201.88535514
10Olfactory transduction_Homo sapiens_hsa047401.84120559
11SNARE interactions in vesicular transport_Homo sapiens_hsa041301.82690255
12Synaptic vesicle cycle_Homo sapiens_hsa047211.82223509
13Cocaine addiction_Homo sapiens_hsa050301.73519364
14Dopaminergic synapse_Homo sapiens_hsa047281.71362919
15N-Glycan biosynthesis_Homo sapiens_hsa005101.70900565
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.69010843
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.66652715
18Circadian entrainment_Homo sapiens_hsa047131.64570237
19Glutamatergic synapse_Homo sapiens_hsa047241.62555497
20Morphine addiction_Homo sapiens_hsa050321.61567269
21Collecting duct acid secretion_Homo sapiens_hsa049661.53001506
22Nicotine addiction_Homo sapiens_hsa050331.51626162
23Type II diabetes mellitus_Homo sapiens_hsa049301.50536082
24Cholinergic synapse_Homo sapiens_hsa047251.44855705
25GABAergic synapse_Homo sapiens_hsa047271.44734488
26Regulation of autophagy_Homo sapiens_hsa041401.41815284
27Type I diabetes mellitus_Homo sapiens_hsa049401.37717270
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35134709
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.24998286
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.24150256
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20246243
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16228737
33Circadian rhythm_Homo sapiens_hsa047101.14299396
34Sphingolipid metabolism_Homo sapiens_hsa006001.05572123
35Renin secretion_Homo sapiens_hsa049241.00401034
36Oxidative phosphorylation_Homo sapiens_hsa001900.96014098
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90782277
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89007690
39Alzheimers disease_Homo sapiens_hsa050100.86208582
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85968318
41Glucagon signaling pathway_Homo sapiens_hsa049220.81086407
42Thyroid hormone synthesis_Homo sapiens_hsa049180.80618914
43Long-term depression_Homo sapiens_hsa047300.78984814
44cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74775255
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74673535
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71347938
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70111238
48Calcium signaling pathway_Homo sapiens_hsa040200.69792932
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69618112
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69367562
51Other glycan degradation_Homo sapiens_hsa005110.69228751
52Prolactin signaling pathway_Homo sapiens_hsa049170.65922315
53Phototransduction_Homo sapiens_hsa047440.63573782
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.62761225
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61369035
56cAMP signaling pathway_Homo sapiens_hsa040240.59746119
57Butanoate metabolism_Homo sapiens_hsa006500.59505819
58Selenocompound metabolism_Homo sapiens_hsa004500.59301249
59Galactose metabolism_Homo sapiens_hsa000520.56634736
60Axon guidance_Homo sapiens_hsa043600.56531893
61Fatty acid elongation_Homo sapiens_hsa000620.56212089
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56052873
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56016505
64Folate biosynthesis_Homo sapiens_hsa007900.55535281
65ErbB signaling pathway_Homo sapiens_hsa040120.55348353
66Melanogenesis_Homo sapiens_hsa049160.55263590
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54898424
68ABC transporters_Homo sapiens_hsa020100.54616934
69Endometrial cancer_Homo sapiens_hsa052130.54077898
70Salivary secretion_Homo sapiens_hsa049700.53361090
71GnRH signaling pathway_Homo sapiens_hsa049120.51741863
72Parkinsons disease_Homo sapiens_hsa050120.50055093
73Steroid biosynthesis_Homo sapiens_hsa001000.49477066
74Pancreatic secretion_Homo sapiens_hsa049720.49283917
75Phagosome_Homo sapiens_hsa041450.44506993
76Lysosome_Homo sapiens_hsa041420.44358411
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44240882
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43760227
79Estrogen signaling pathway_Homo sapiens_hsa049150.43722843
80Oxytocin signaling pathway_Homo sapiens_hsa049210.43200695
81Ether lipid metabolism_Homo sapiens_hsa005650.42314116
82MAPK signaling pathway_Homo sapiens_hsa040100.40063042
83Huntingtons disease_Homo sapiens_hsa050160.39598480
84Alcoholism_Homo sapiens_hsa050340.38979914
85Prostate cancer_Homo sapiens_hsa052150.36801655
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36421146
87Insulin signaling pathway_Homo sapiens_hsa049100.35586725
88Insulin resistance_Homo sapiens_hsa049310.35333206
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34431991
90Prion diseases_Homo sapiens_hsa050200.34233796
91Rheumatoid arthritis_Homo sapiens_hsa053230.34230819
92Gastric acid secretion_Homo sapiens_hsa049710.33856071
93Melanoma_Homo sapiens_hsa052180.33230794
94Ras signaling pathway_Homo sapiens_hsa040140.30425390
95Gap junction_Homo sapiens_hsa045400.30402595
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.29847252
97Choline metabolism in cancer_Homo sapiens_hsa052310.26561135
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.26040041
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25989020
100Wnt signaling pathway_Homo sapiens_hsa043100.25513439

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