GPR33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.38566823
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.38566823
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.38566823
4modulation by symbiont of host immune response (GO:0052553)6.38566823
5positive regulation by symbiont of host defense response (GO:0052509)6.38566823
6modulation by symbiont of host defense response (GO:0052031)6.38566823
7cellular response to exogenous dsRNA (GO:0071360)6.33915942
8positive regulation of chemokine biosynthetic process (GO:0045080)6.15731722
9intracellular pH reduction (GO:0051452)6.11702794
10fat-soluble vitamin biosynthetic process (GO:0042362)5.96988173
11regulation of T-helper 1 cell differentiation (GO:0045625)5.74708246
12antigen processing and presentation of endogenous antigen (GO:0019883)5.53018558
13negative regulation of type 2 immune response (GO:0002829)5.37327581
14regulation of T-helper 2 cell differentiation (GO:0045628)5.17713567
15microglial cell activation (GO:0001774)5.13720331
16cellular response to interferon-beta (GO:0035458)4.97634434
17pH reduction (GO:0045851)4.86493767
18natural killer cell mediated cytotoxicity (GO:0042267)4.81629254
19natural killer cell mediated immunity (GO:0002228)4.81629254
20positive regulation of monocyte chemotaxis (GO:0090026)4.81550314
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.70739516
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.70739516
23positive regulation of natural killer cell differentiation (GO:0032825)4.67849883
24response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.65840597
25response to host immune response (GO:0052572)4.65840597
26positive regulation of interferon-alpha production (GO:0032727)4.58925540
27positive regulation of T-helper 1 type immune response (GO:0002827)4.55742801
28regulation of chemokine biosynthetic process (GO:0045073)4.54923536
29regulation of phospholipase A2 activity (GO:0032429)4.52738547
30positive regulation of alpha-beta T cell proliferation (GO:0046641)4.50305776
31cellular extravasation (GO:0045123)4.41750514
32positive regulation of interleukin-17 production (GO:0032740)4.34351278
33regulation of interferon-beta biosynthetic process (GO:0045357)4.34017466
34immunoglobulin mediated immune response (GO:0016064)4.24687077
35regulation of interferon-alpha production (GO:0032647)4.24639911
36regulation of B cell receptor signaling pathway (GO:0050855)4.21916392
37positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.16131179
38I-kappaB phosphorylation (GO:0007252)4.07583046
39response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.06292427
40response to host (GO:0075136)4.06292427
41response to host defenses (GO:0052200)4.06292427
42regulation of alpha-beta T cell proliferation (GO:0046640)3.98448030
43cellular response to type I interferon (GO:0071357)3.95944944
44type I interferon signaling pathway (GO:0060337)3.95944944
45macrophage activation involved in immune response (GO:0002281)3.94560046
46regulation of type 2 immune response (GO:0002828)3.89935276
47response to type I interferon (GO:0034340)3.88041672
48interferon-gamma-mediated signaling pathway (GO:0060333)3.84985201
49Arp2/3 complex-mediated actin nucleation (GO:0034314)3.63141287
50positive regulation of T-helper cell differentiation (GO:0045624)3.62322137
51regulation of dendritic cell antigen processing and presentation (GO:0002604)3.62315763
52myeloid dendritic cell differentiation (GO:0043011)3.61219690
53positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.59581235
54regulation of interferon-gamma biosynthetic process (GO:0045072)3.58233870
55pinocytosis (GO:0006907)3.58184907
56positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.56426574
57regulation of T-helper 1 type immune response (GO:0002825)3.52619514
58cellular response to interferon-gamma (GO:0071346)3.44729755
59response to interferon-beta (GO:0035456)3.42789928
60cellular response to interferon-alpha (GO:0035457)3.42112189
61regulation of monocyte chemotaxis (GO:0090025)3.39350458
62G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.36265829
63negative regulation of B cell mediated immunity (GO:0002713)3.33463300
64negative regulation of immunoglobulin mediated immune response (GO:0002890)3.33463300
65regulation of extracellular matrix disassembly (GO:0010715)3.31686739
66T cell migration (GO:0072678)3.27913371
67phosphatidylinositol acyl-chain remodeling (GO:0036149)3.24161979
68positive regulation of toll-like receptor signaling pathway (GO:0034123)3.21652673
69regulation of intracellular pH (GO:0051453)3.21383891
70regulation of lymphocyte migration (GO:2000401)3.19295710
71natural killer cell differentiation (GO:0001779)3.18442700
72regulation of cellular extravasation (GO:0002691)3.15165421
73positive regulation of type 2 immune response (GO:0002830)3.11781621
74regulation of natural killer cell differentiation (GO:0032823)3.11318636
75positive regulation of interleukin-12 production (GO:0032735)3.08357982
76cellular response to dsRNA (GO:0071359)3.08256929
77regulation of interleukin-17 production (GO:0032660)3.08012156
78positive regulation of response to biotic stimulus (GO:0002833)3.06858113
79natural killer cell activation (GO:0030101)3.05234700
80myeloid dendritic cell activation (GO:0001773)3.02443262
81response to interferon-gamma (GO:0034341)3.02124893
82positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.01976582
83positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.99842329
84membrane raft organization (GO:0031579)2.98971240
85leukocyte mediated cytotoxicity (GO:0001909)2.97984093
86lymphocyte chemotaxis (GO:0048247)2.95495953
87negative regulation of T-helper cell differentiation (GO:0045623)2.95267556
88negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.95267556
89positive regulation of antigen processing and presentation (GO:0002579)2.92018723
90actin nucleation (GO:0045010)2.88867859
91regulation of cellular pH (GO:0030641)2.88735313
92response to peptidoglycan (GO:0032494)2.88223899
93grooming behavior (GO:0007625)2.87278853
94regulation of B cell mediated immunity (GO:0002712)2.86953832
95macrophage activation (GO:0042116)2.85923614
96negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.85738938
97B cell mediated immunity (GO:0019724)2.85575599
98regulation of natural killer cell activation (GO:0032814)2.85335810
99regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.81827351
100sphingolipid catabolic process (GO:0030149)2.81470742

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse7.97487842
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.35405659
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.50646167
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.64010292
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.38753736
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.16679431
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.71657831
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.27287461
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.61845825
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39709388
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.29307013
12* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.24336772
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.14660724
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.09473591
15IKZF1_21737484_ChIP-ChIP_HCT116_Human2.06777875
16EGR1_19032775_ChIP-ChIP_M12_Human2.04452908
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.96228361
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95250289
19CDX2_19796622_ChIP-Seq_MESCs_Mouse1.91982971
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.86895105
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.86168644
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.69696056
23GATA1_22025678_ChIP-Seq_K562_Human1.67690690
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65665105
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53081585
26SPI1_23127762_ChIP-Seq_K562_Human1.52002916
27EZH2_22144423_ChIP-Seq_EOC_Human1.50617731
28TAF15_26573619_Chip-Seq_HEK293_Human1.49895323
29MYB_26560356_Chip-Seq_TH2_Human1.46309500
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33911173
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28287145
32AR_21572438_ChIP-Seq_LNCaP_Human1.24937074
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23025741
34RUNX_20019798_ChIP-Seq_JUKART_Human1.21571968
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20633510
36MAF_26560356_Chip-Seq_TH1_Human1.16630678
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15156345
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12118334
39CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11743107
40TRIM28_21343339_ChIP-Seq_HEK293_Human1.11156867
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10934453
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10725764
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09970286
44PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09687919
45NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08311324
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06915653
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.06494776
48GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06069381
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04311958
50VDR_24787735_ChIP-Seq_THP-1_Human1.03720036
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02937700
52FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99828619
53CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97677284
54GATA3_27048872_Chip-Seq_THYMUS_Human0.97278798
55RXR_22108803_ChIP-Seq_LS180_Human0.96423109
56JARID2_20075857_ChIP-Seq_MESCs_Mouse0.95780615
57CDX2_20551321_ChIP-Seq_CACO-2_Human0.94360995
58SPI1_23547873_ChIP-Seq_NB4_Human0.93748260
59GATA3_26560356_Chip-Seq_TH2_Human0.93236880
60SMAD_19615063_ChIP-ChIP_OVARY_Human0.93119101
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89271858
62TP53_18474530_ChIP-ChIP_U2OS_Human0.88680063
63MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88408665
64MYB_26560356_Chip-Seq_TH1_Human0.87452011
65EZH2_27304074_Chip-Seq_ESCs_Mouse0.86869070
66SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.86815724
67PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85729005
68MTF2_20144788_ChIP-Seq_MESCs_Mouse0.84955185
69SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.84823149
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84148404
71RNF2_18974828_ChIP-Seq_MESCs_Mouse0.80461216
72EZH2_18974828_ChIP-Seq_MESCs_Mouse0.80461216
73TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.79879109
74EZH2_27294783_Chip-Seq_ESCs_Mouse0.78544781
75LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.78117480
76DROSHA_22980978_ChIP-Seq_HELA_Human0.77594597
77CMYC_18555785_Chip-Seq_ESCs_Mouse0.77365896
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.76623776
79SOX2_20726797_ChIP-Seq_SW620_Human0.75421558
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.74402156
81SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.74131698
82VDR_24763502_ChIP-Seq_THP-1_Human0.72738931
83OCT1_27270436_Chip-Seq_PROSTATE_Human0.72429486
84* PU_27001747_Chip-Seq_BMDM_Mouse0.71830655
85SMRT_27268052_Chip-Seq_Bcells_Human0.71712544
86P300_19829295_ChIP-Seq_ESCs_Human0.69930115
87NRF2_20460467_ChIP-Seq_MEFs_Mouse0.69375544
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.69375544
89TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.68137677
90SCL_19346495_ChIP-Seq_HPC-7_Human0.67985383
91EED_16625203_ChIP-ChIP_MESCs_Mouse0.67777969
92E2F1_18555785_Chip-Seq_ESCs_Mouse0.67574801
93SUZ12_27294783_Chip-Seq_ESCs_Mouse0.64879600
94PU1_27457419_Chip-Seq_LIVER_Mouse0.64618365
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.63590164
96CJUN_26792858_Chip-Seq_BT549_Human0.63085203
97P53_22127205_ChIP-Seq_FIBROBLAST_Human0.62254691
98SUZ12_18555785_Chip-Seq_ESCs_Mouse0.61543770
99P300_18555785_Chip-Seq_ESCs_Mouse0.61396140
100PRDM14_20953172_ChIP-Seq_ESCs_Human0.60622650

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation7.17363746
2MP0004510_myositis4.38093009
3MP0006082_CNS_inflammation3.45563659
4MP0000685_abnormal_immune_system3.43662840
5MP0005387_immune_system_phenotype3.15101596
6MP0001790_abnormal_immune_system3.15101596
7MP0009785_altered_susceptibility_to3.14022397
8MP0002148_abnormal_hypersensitivity_rea3.02325508
9MP0005451_abnormal_body_composition2.82752983
10MP0010234_abnormal_vibrissa_follicle2.76319511
11MP0002452_abnormal_antigen_presenting2.57657185
12MP0005000_abnormal_immune_tolerance2.55423563
13MP0001800_abnormal_humoral_immune2.48024890
14MP0003436_decreased_susceptibility_to2.45995996
15MP0009046_muscle_twitch2.43487769
16MP0002419_abnormal_innate_immunity2.41689367
17MP0005025_abnormal_response_to2.39812428
18MP0005671_abnormal_response_to2.33576689
19MP0009764_decreased_sensitivity_to2.19862126
20MP0001873_stomach_inflammation2.13825748
21MP0001853_heart_inflammation2.11839596
22MP0001819_abnormal_immune_cell2.06873996
23MP0002723_abnormal_immune_serum2.03742090
24MP0000566_synostosis1.94192694
25MP0005623_abnormal_meninges_morphology1.94159555
26MP0003303_peritoneal_inflammation1.91297982
27MP0002420_abnormal_adaptive_immunity1.91297312
28MP0002405_respiratory_system_inflammati1.83921129
29MP0001958_emphysema1.65662203
30MP0009333_abnormal_splenocyte_physiolog1.63658671
31MP0003448_altered_tumor_morphology1.62677241
32MP0003075_altered_response_to1.61837919
33MP0005423_abnormal_somatic_nervous1.61551046
34MP0002006_tumorigenesis1.61489240
35MP0005645_abnormal_hypothalamus_physiol1.59592789
36MP0005464_abnormal_platelet_physiology1.55657184
37MP0002876_abnormal_thyroid_physiology1.49826833
38MP0005084_abnormal_gallbladder_morpholo1.44621911
39MP0002166_altered_tumor_susceptibility1.44584170
40MP0002396_abnormal_hematopoietic_system1.43248372
41MP0003045_fibrosis1.41402396
42MP0000716_abnormal_immune_system1.36790136
43MP0002933_joint_inflammation1.34328615
44MP0001845_abnormal_inflammatory_respons1.31618218
45MP0001440_abnormal_grooming_behavior1.31386727
46MP0005166_decreased_susceptibility_to1.30108725
47MP0009780_abnormal_chondrocyte_physiolo1.27204889
48MP0002398_abnormal_bone_marrow1.22347464
49MP0002138_abnormal_hepatobiliary_system1.19334918
50MP0003941_abnormal_skin_development1.19266096
51MP0001533_abnormal_skeleton_physiology1.18773844
52MP0000343_altered_response_to1.17758332
53MP0003453_abnormal_keratinocyte_physiol1.14241693
54MP0005360_urolithiasis1.13902604
55MP0008469_abnormal_protein_level1.11348241
56MP0002090_abnormal_vision1.11055944
57MP0000689_abnormal_spleen_morphology1.08304106
58MP0005310_abnormal_salivary_gland1.08086114
59MP0002429_abnormal_blood_cell1.07962513
60MP0004947_skin_inflammation1.05651841
61MP0003866_abnormal_defecation0.99590241
62MP0000858_altered_metastatic_potential0.99249672
63MP0000604_amyloidosis0.99082500
64MP0002722_abnormal_immune_system0.95294215
65MP0002998_abnormal_bone_remodeling0.90617011
66MP0002064_seizures0.88581003
67MP0003724_increased_susceptibility_to0.84766251
68MP0004859_abnormal_synaptic_plasticity0.82344538
69MP0001881_abnormal_mammary_gland0.81504302
70MP0009763_increased_sensitivity_to0.79761429
71MP0002168_other_aberrant_phenotype0.79150896
72MP0000470_abnormal_stomach_morphology0.77574514
73MP0004142_abnormal_muscle_tone0.75347509
74MP0000467_abnormal_esophagus_morphology0.74228234
75MP0003763_abnormal_thymus_physiology0.74187533
76MP0003638_abnormal_response/metabolism_0.71824073
77MP0003091_abnormal_cell_migration0.71400602
78MP0010155_abnormal_intestine_physiology0.68940713
79MP0003690_abnormal_glial_cell0.68521558
80MP0005395_other_phenotype0.67388254
81MP0005584_abnormal_enzyme/coenzyme_acti0.66328382
82MP0003329_amyloid_beta_deposits0.65876906
83MP0002136_abnormal_kidney_physiology0.65267088
84MP0002693_abnormal_pancreas_physiology0.65113192
85MP0001663_abnormal_digestive_system0.63596715
86MP0003787_abnormal_imprinting0.63204653
87MP0000920_abnormal_myelination0.60495882
88MP0003252_abnormal_bile_duct0.59577497
89MP0005248_abnormal_Harderian_gland0.57306721
90MP0003718_maternal_effect0.56777531
91MP0003186_abnormal_redox_activity0.56595649
92MP0005390_skeleton_phenotype0.54196548
93MP0005595_abnormal_vascular_smooth0.52799072
94MP0009745_abnormal_behavioral_response0.50319974
95MP0001851_eye_inflammation0.48175284
96MP0006138_congestive_heart_failure0.47603605
97MP0008874_decreased_physiological_sensi0.46092265
98MP0001348_abnormal_lacrimal_gland0.45802119
99MP0000598_abnormal_liver_morphology0.42983721
100MP0005165_increased_susceptibility_to0.42439455

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)6.39864288
2Increased neuronal autofluorescent lipopigment (HP:0002074)5.59705537
3Recurrent abscess formation (HP:0002722)5.47871385
4Vacuolated lymphocytes (HP:0001922)5.27504949
5Loss of speech (HP:0002371)5.22986865
6Increased cerebral lipofuscin (HP:0011813)5.22796900
7Recurrent bacterial skin infections (HP:0005406)4.97645785
8Hyperventilation (HP:0002883)4.73519836
9Conjugated hyperbilirubinemia (HP:0002908)4.43973710
10Elevated erythrocyte sedimentation rate (HP:0003565)4.06248295
11IgM deficiency (HP:0002850)3.61029682
12Progressive microcephaly (HP:0000253)3.55463865
13Recurrent gram-negative bacterial infections (HP:0005420)3.54368483
14Eczematoid dermatitis (HP:0000976)3.54287184
15J-shaped sella turcica (HP:0002680)3.52955856
16Myositis (HP:0100614)3.51443425
17Azoospermia (HP:0000027)3.25634911
18Abnormality of glycosphingolipid metabolism (HP:0004343)3.23618733
19Abnormality of glycolipid metabolism (HP:0010969)3.23618733
20Abnormality of liposaccharide metabolism (HP:0010968)3.23618733
21Recurrent skin infections (HP:0001581)3.19983542
22Recurrent viral infections (HP:0004429)3.19251243
23Polygenic inheritance (HP:0010982)3.14911835
24Chronic obstructive pulmonary disease (HP:0006510)3.07927543
25Obstructive lung disease (HP:0006536)3.07927543
26Amyloidosis (HP:0011034)3.05719106
27Basal ganglia calcification (HP:0002135)2.95487741
28Decreased electroretinogram (ERG) amplitude (HP:0000654)2.91721098
29Gingival bleeding (HP:0000225)2.88367758
30Increased IgM level (HP:0003496)2.88250895
31Chronic sinusitis (HP:0011109)2.84145624
32Abnormality of the lumbar spine (HP:0100712)2.80288470
33Vasculitis (HP:0002633)2.80201286
34Panhypogammaglobulinemia (HP:0003139)2.77669211
35Macular degeneration (HP:0000608)2.76249213
36Acrocyanosis (HP:0001063)2.75279276
37Recurrent bronchitis (HP:0002837)2.70942931
38Restrictive lung disease (HP:0002091)2.70467659
39Nephritis (HP:0000123)2.70133969
40Nasal polyposis (HP:0100582)2.64128147
41Prolonged partial thromboplastin time (HP:0003645)2.61916732
42Abnormality of complement system (HP:0005339)2.57169752
43Abolished electroretinogram (ERG) (HP:0000550)2.56945368
44Pustule (HP:0200039)2.56135799
45Xerostomia (HP:0000217)2.53825971
46Hypergammaglobulinemia (HP:0010702)2.53226691
47Absent frontal sinuses (HP:0002688)2.52977606
48Deformed sella turcica (HP:0002681)2.50315030
49Squamous cell carcinoma (HP:0002860)2.49382438
50Urethral obstruction (HP:0000796)2.48148296
51Recurrent fungal infections (HP:0002841)2.47085788
52Selective tooth agenesis (HP:0001592)2.46192079
53Gingivitis (HP:0000230)2.44751624
54Abnormality of the nasal mucosa (HP:0000433)2.43731558
55Mediastinal lymphadenopathy (HP:0100721)2.41461732
56Hemoptysis (HP:0002105)2.34987714
57Recurrent cutaneous fungal infections (HP:0011370)2.32408230
58Chronic mucocutaneous candidiasis (HP:0002728)2.32408230
59Meningitis (HP:0001287)2.30814611
60IgA deficiency (HP:0002720)2.30539188
61Poor head control (HP:0002421)2.27998860
62Abnormality of the pleura (HP:0002103)2.25600646
63Acute myeloid leukemia (HP:0004808)2.24355522
64Abnormality of macrophages (HP:0004311)2.24073877
65Systemic lupus erythematosus (HP:0002725)2.22781727
66Mucopolysacchariduria (HP:0008155)2.21391869
67Urinary glycosaminoglycan excretion (HP:0003541)2.21391869
68Agammaglobulinemia (HP:0004432)2.15004012
69Emphysema (HP:0002097)2.11764405
70Abnormality of polysaccharide metabolism (HP:0011012)2.11434794
71Abnormality of glycosaminoglycan metabolism (HP:0004371)2.11434794
72Abnormality of mucopolysaccharide metabolism (HP:0011020)2.11434794
73IgG deficiency (HP:0004315)2.10284911
74Neonatal short-limb short stature (HP:0008921)2.08442346
75Autoimmune hemolytic anemia (HP:0001890)2.06943895
76Abnormal number of incisors (HP:0011064)2.05431213
77Gastrointestinal infarctions (HP:0005244)2.03180154
78Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.01795669
79Progressive visual loss (HP:0000529)2.00746334
80Abnormality of the sella turcica (HP:0002679)2.00699662
81Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.95953640
82Periodontitis (HP:0000704)1.94420866
83Arterial thrombosis (HP:0004420)1.93985645
84Joint swelling (HP:0001386)1.92927847
85Oral leukoplakia (HP:0002745)1.92630254
86Pulmonary infiltrates (HP:0002113)1.92483595
87Osteolytic defects of the hand bones (HP:0009699)1.92167551
88Osteolytic defects of the phalanges of the hand (HP:0009771)1.92167551
89Skin rash (HP:0000988)1.91910051
90Abnormal spermatogenesis (HP:0008669)1.91640413
91Polyneuropathy (HP:0001271)1.91624006
92Abnormality of the pericardium (HP:0001697)1.91142480
93Cheilitis (HP:0100825)1.90893484
94Interstitial pulmonary disease (HP:0006530)1.85136897
95Abnormality of the prostate (HP:0008775)1.84252443
96Cervical subluxation (HP:0003308)1.83291369
97Peritonitis (HP:0002586)1.81244532
98Hemangiomatosis (HP:0007461)1.79996649
99Tinnitus (HP:0000360)1.79896053
100Skin ulcer (HP:0200042)1.78960737

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.86112201
2BLK4.64651317
3MAP3K144.56363505
4EPHB13.46550565
5CDK193.13434711
6JAK32.80942410
7TYK22.78153765
8FGFR42.70723349
9KIT2.64131393
10FGFR32.28071709
11TBK12.28064442
12TAOK32.25109229
13JAK12.22570022
14RIPK42.22508953
15RIPK11.88287382
16EPHA31.87238359
17MYLK1.81083100
18IKBKE1.80449014
19IRAK41.72115488
20ITK1.68517540
21OXSR11.63306091
22EIF2AK21.59818826
23TAOK11.51155843
24TTK1.51087080
25FES1.38042045
26IKBKB1.35408640
27CSK1.34971391
28STK161.33841720
29CSF1R1.31372382
30MAP4K11.29588221
31SYK1.28941940
32EIF2AK11.28895624
33PAK41.19941508
34CSNK1A1L1.12262493
35PKN11.11814418
36JAK21.11204106
37BMX1.10905520
38FGR1.05375019
39MAP3K131.04062733
40MAP3K51.01233942
41ERN11.00106922
42CSNK1G30.91689010
43PBK0.83948597
44LRRK20.83671257
45GRK10.82688638
46LCK0.79165816
47TXK0.78478603
48CAMKK10.75834897
49DAPK30.74030705
50ALK0.73004820
51LYN0.72237640
52ATR0.70295019
53ABL20.66484680
54NUAK10.66457465
55TEC0.63066690
56BMPR20.60871683
57SIK10.60844063
58BTK0.59349594
59DAPK10.58880303
60STK100.58042687
61FLT30.54492788
62ILK0.53559251
63LATS20.53185329
64PDK10.50177121
65PRKCQ0.49863051
66PRKCD0.49300315
67CSNK1G10.48874537
68ZAP700.48694866
69CSNK1G20.46918101
70LATS10.44980360
71VRK10.44205184
72NTRK20.43089722
73HIPK20.40986670
74NTRK30.40561860
75ABL10.37946599
76DYRK1B0.37766827
77PDPK10.32807264
78IGF1R0.32720098
79PRKG20.32253750
80NLK0.31077415
81DAPK20.29547412
82IRAK30.28564797
83PKN20.28027149
84FYN0.27931177
85CHUK0.27741648
86MAP2K70.27280186
87KDR0.26079582
88ROCK20.25673138
89PTK2B0.25620486
90STK110.25561653
91SIK20.25201281
92ADRBK20.23907851
93BCR0.23677598
94ADRBK10.23162637
95WNK10.23087202
96DMPK0.22760946
97GRK60.22465679
98IRAK10.20989009
99NME10.19159139
100MST40.18484541

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.49998592
2Fatty acid elongation_Homo sapiens_hsa000623.29115549
3Allograft rejection_Homo sapiens_hsa053302.94529459
4Viral myocarditis_Homo sapiens_hsa054162.68782495
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.64387998
6Type I diabetes mellitus_Homo sapiens_hsa049402.44018434
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.29582967
8Staphylococcus aureus infection_Homo sapiens_hsa051502.28243953
9Leishmaniasis_Homo sapiens_hsa051402.26715425
10Salmonella infection_Homo sapiens_hsa051322.21372324
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.21117530
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.11266745
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.01867754
14Measles_Homo sapiens_hsa051621.86506229
15Malaria_Homo sapiens_hsa051441.85537095
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.83856886
17Rheumatoid arthritis_Homo sapiens_hsa053231.80831578
18African trypanosomiasis_Homo sapiens_hsa051431.80250731
19Antigen processing and presentation_Homo sapiens_hsa046121.79419616
20Chemokine signaling pathway_Homo sapiens_hsa040621.77403302
21Autoimmune thyroid disease_Homo sapiens_hsa053201.74982897
22Herpes simplex infection_Homo sapiens_hsa051681.72284572
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.63732682
24Influenza A_Homo sapiens_hsa051641.62527209
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.57074770
26Primary immunodeficiency_Homo sapiens_hsa053401.56452405
27Nitrogen metabolism_Homo sapiens_hsa009101.54936514
28Osteoclast differentiation_Homo sapiens_hsa043801.54320996
29Lysosome_Homo sapiens_hsa041421.53778932
30Tuberculosis_Homo sapiens_hsa051521.49531243
31Complement and coagulation cascades_Homo sapiens_hsa046101.47474006
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.47126607
33Apoptosis_Homo sapiens_hsa042101.36621795
34Fatty acid metabolism_Homo sapiens_hsa012121.35619847
35TNF signaling pathway_Homo sapiens_hsa046681.35460316
36Shigellosis_Homo sapiens_hsa051311.34747830
37Homologous recombination_Homo sapiens_hsa034401.32401514
38Toxoplasmosis_Homo sapiens_hsa051451.30422428
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30039554
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.27040672
41Pertussis_Homo sapiens_hsa051331.26116347
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.20137394
43Hepatitis C_Homo sapiens_hsa051601.14034884
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.13480099
45Phagosome_Homo sapiens_hsa041451.13014952
46B cell receptor signaling pathway_Homo sapiens_hsa046621.11620255
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08291684
48Tryptophan metabolism_Homo sapiens_hsa003801.05859240
49NOD-like receptor signaling pathway_Homo sapiens_hsa046211.04450182
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01350497
51Jak-STAT signaling pathway_Homo sapiens_hsa046301.00893090
52Dorso-ventral axis formation_Homo sapiens_hsa043200.93904717
53Prolactin signaling pathway_Homo sapiens_hsa049170.89234376
54Legionellosis_Homo sapiens_hsa051340.87452915
55Hepatitis B_Homo sapiens_hsa051610.85315354
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83935392
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76298595
58Platelet activation_Homo sapiens_hsa046110.74474725
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74296974
60T cell receptor signaling pathway_Homo sapiens_hsa046600.73127013
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.71149258
62ABC transporters_Homo sapiens_hsa020100.69313173
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68888868
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66318870
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62918664
66Phenylalanine metabolism_Homo sapiens_hsa003600.62724790
67Salivary secretion_Homo sapiens_hsa049700.61449292
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.60951557
69Acute myeloid leukemia_Homo sapiens_hsa052210.53116842
70Amoebiasis_Homo sapiens_hsa051460.51176593
71Prion diseases_Homo sapiens_hsa050200.44469471
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44284935
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42825021
74Notch signaling pathway_Homo sapiens_hsa043300.39567240
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.37852269
76Arginine biosynthesis_Homo sapiens_hsa002200.36118845
77Morphine addiction_Homo sapiens_hsa050320.32741151
78MAPK signaling pathway_Homo sapiens_hsa040100.31993322
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29459454
80Other glycan degradation_Homo sapiens_hsa005110.29320633
81Selenocompound metabolism_Homo sapiens_hsa004500.27042845
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26550082
83Circadian entrainment_Homo sapiens_hsa047130.26257452
84Pancreatic cancer_Homo sapiens_hsa052120.26207329
85Fatty acid biosynthesis_Homo sapiens_hsa000610.25911057
86Mineral absorption_Homo sapiens_hsa049780.25827893
87Nicotine addiction_Homo sapiens_hsa050330.25374198
88Fatty acid degradation_Homo sapiens_hsa000710.24388656
89GABAergic synapse_Homo sapiens_hsa047270.24338547
90Vibrio cholerae infection_Homo sapiens_hsa051100.24085918
91Hematopoietic cell lineage_Homo sapiens_hsa046400.23210566
92Synaptic vesicle cycle_Homo sapiens_hsa047210.23038171
93p53 signaling pathway_Homo sapiens_hsa041150.20620808
94Glutamatergic synapse_Homo sapiens_hsa047240.19499789
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.19453336
96Starch and sucrose metabolism_Homo sapiens_hsa005000.18350114
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.17499948
98Butanoate metabolism_Homo sapiens_hsa006500.16780039
99Serotonergic synapse_Homo sapiens_hsa047260.16374205
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.14082967

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »