GPR31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of T-helper 1 cell differentiation (GO:0045625)7.62970273
2regulation of chronic inflammatory response (GO:0002676)6.65049081
3regulation of dendritic cell antigen processing and presentation (GO:0002604)6.04940665
4regulation of vitamin D biosynthetic process (GO:0060556)5.52836689
5kynurenine metabolic process (GO:0070189)5.25046788
6positive regulation of type 2 immune response (GO:0002830)5.11835964
7negative regulation of interleukin-12 production (GO:0032695)5.08508113
8positive regulation of T-helper cell differentiation (GO:0045624)5.00838561
9positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.93889552
10indole-containing compound catabolic process (GO:0042436)4.87787924
11indolalkylamine catabolic process (GO:0046218)4.87787924
12tryptophan catabolic process (GO:0006569)4.87787924
13positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.73290678
14T-helper 1 type immune response (GO:0042088)4.66861066
15positive regulation of antigen processing and presentation (GO:0002579)4.58087670
16regulation of T-helper cell differentiation (GO:0045622)4.54396341
17regulation of cytokine secretion involved in immune response (GO:0002739)4.42746447
18positive regulation of interleukin-12 production (GO:0032735)4.41325274
19regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.38854808
20regulation of T cell tolerance induction (GO:0002664)4.38415894
21positive regulation of T-helper 1 type immune response (GO:0002827)4.37508099
22regulation of vitamin metabolic process (GO:0030656)4.37080374
23regulation of interleukin-12 production (GO:0032655)4.36300958
24regulation of interferon-alpha production (GO:0032647)4.35104173
25regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)4.22273869
26regulation of antigen processing and presentation (GO:0002577)4.21129922
27positive regulation of NF-kappaB import into nucleus (GO:0042346)4.17928244
28cellular response to type I interferon (GO:0071357)4.16992990
29type I interferon signaling pathway (GO:0060337)4.16992990
30cellular biogenic amine catabolic process (GO:0042402)4.13729252
31amine catabolic process (GO:0009310)4.13729252
32regulation of T-helper 1 type immune response (GO:0002825)4.12546252
33response to type I interferon (GO:0034340)4.12218856
34negative regulation of interleukin-10 production (GO:0032693)4.10905224
35positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)4.04354116
36positive regulation of cAMP-mediated signaling (GO:0043950)4.03711308
37positive regulation of tolerance induction (GO:0002645)4.01419452
38response to peptidoglycan (GO:0032494)3.98319907
39positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.96928077
40positive regulation of heat generation (GO:0031652)3.94188220
41regulation of fever generation (GO:0031620)3.89957552
42defense response to protozoan (GO:0042832)3.89731236
43production of molecular mediator involved in inflammatory response (GO:0002532)3.89303314
44regulation of interferon-gamma biosynthetic process (GO:0045072)3.87721248
45lipopolysaccharide-mediated signaling pathway (GO:0031663)3.86034706
46tryptophan metabolic process (GO:0006568)3.79688412
47positive regulation of defense response to virus by host (GO:0002230)3.78406989
48regulation of tolerance induction (GO:0002643)3.72538506
49response to protozoan (GO:0001562)3.68554175
50positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.68475652
51regulation of interleukin-1 beta secretion (GO:0050706)3.63885985
52interferon-gamma-mediated signaling pathway (GO:0060333)3.62950010
53positive regulation of chemokine biosynthetic process (GO:0045080)3.61103897
54regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.60256566
55macrophage activation involved in immune response (GO:0002281)3.59949941
56negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.58930843
57positive regulation of interferon-alpha production (GO:0032727)3.58709132
58regulation of podosome assembly (GO:0071801)3.55015612
59branching involved in labyrinthine layer morphogenesis (GO:0060670)3.54742874
60regulation of type 2 immune response (GO:0002828)3.53917024
61regulation of chemokine biosynthetic process (GO:0045073)3.52942512
62NIK/NF-kappaB signaling (GO:0038061)3.51171849
63positive regulation of interleukin-1 beta secretion (GO:0050718)3.49189039
64positive regulation of Cdc42 GTPase activity (GO:0043089)3.41512471
65positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.40786806
66positive regulation of gamma-delta T cell activation (GO:0046645)3.36536803
67regulation of mononuclear cell migration (GO:0071675)3.32769175
68dendritic cell differentiation (GO:0097028)3.31738993
69negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.31625247
70regulation of interferon-beta biosynthetic process (GO:0045357)3.30948885
71modulation of growth of symbiont involved in interaction with host (GO:0044144)3.30021707
72regulation of growth of symbiont in host (GO:0044126)3.30021707
73negative regulation of growth of symbiont in host (GO:0044130)3.30021707
74negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.30021707
75interferon-gamma secretion (GO:0072643)3.29904519
76regulation of NF-kappaB import into nucleus (GO:0042345)3.28576578
77regulation of interleukin-10 production (GO:0032653)3.27601852
78positive regulation of interleukin-1 secretion (GO:0050716)3.26537172
79regulation of interleukin-1 secretion (GO:0050704)3.24102227
80positive regulation of interleukin-10 production (GO:0032733)3.23534592
81regulation of immunoglobulin secretion (GO:0051023)3.19013232
82positive regulation of nitric oxide biosynthetic process (GO:0045429)3.13724515
83regulation of inflammatory response to antigenic stimulus (GO:0002861)3.13636470
84cellular response to lipopolysaccharide (GO:0071222)3.11201034
85regulation of interleukin-8 biosynthetic process (GO:0045414)3.10859668
86positive regulation of interleukin-17 production (GO:0032740)3.09045609
87immunoglobulin mediated immune response (GO:0016064)3.07521843
88negative regulation of cytokine production involved in immune response (GO:0002719)3.06731028
89myeloid dendritic cell differentiation (GO:0043011)3.05660562
90regulation of nitric oxide biosynthetic process (GO:0045428)3.04069284
91cellular response to molecule of bacterial origin (GO:0071219)3.03104537
92modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.02248039
93positive regulation by organism of defense response of other organism involved in symbiotic interact3.02248039
94modulation by symbiont of host immune response (GO:0052553)3.02248039
95positive regulation by symbiont of host defense response (GO:0052509)3.02248039
96modulation by symbiont of host defense response (GO:0052031)3.02248039
97modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.02248039
98positive regulation of alpha-beta T cell differentiation (GO:0046638)3.00518465
99positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.00449333
100cellular response to interferon-gamma (GO:0071346)2.98467002

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.30516831
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.54769823
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.39425999
4RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human4.78713983
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.40113402
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.14524634
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.79896561
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.08559434
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.02717380
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.02020134
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.01319848
12STAT4_19710469_ChIP-ChIP_TH1__Mouse3.01088217
13GATA1_22025678_ChIP-Seq_K562_Human2.91262216
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.81995673
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.79637748
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.69611029
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.64136787
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.39940096
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.32513783
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.32513783
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.32513783
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.28997771
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.25494309
24VDR_24787735_ChIP-Seq_THP-1_Human1.89459452
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.86880721
26PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.85530898
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.78945014
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.61165732
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60155147
30SCL_19346495_ChIP-Seq_HPC-7_Human1.54548194
31FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.49656530
32RUNX_20019798_ChIP-Seq_JUKART_Human1.49449211
33NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.49026034
34SPI1_23127762_ChIP-Seq_K562_Human1.44330090
35CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43620704
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42182828
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40661733
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.39519563
39GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.39490587
40LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.37912760
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34727006
42EGR1_19032775_ChIP-ChIP_M12_Human1.32930479
43SPI1_23547873_ChIP-Seq_NB4_Human1.25117225
44PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25016764
45MAF_26560356_Chip-Seq_TH1_Human1.24350743
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23523081
47TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23380350
48MYB_26560356_Chip-Seq_TH2_Human1.20983119
49VDR_24763502_ChIP-Seq_THP-1_Human1.20293992
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18641007
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.14885919
52ESR1_21235772_ChIP-Seq_MCF-7_Human1.12942510
53PU_27001747_Chip-Seq_BMDM_Mouse1.12494402
54CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12441666
55PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11371637
56CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10477079
57GATA1_19941826_ChIP-Seq_K562_Human1.08989728
58SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08490957
59VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07270258
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06527316
61TP63_17297297_ChIP-ChIP_HaCaT_Human1.05875567
62STAT1_20625510_ChIP-Seq_HELA_Human1.05132447
63GATA3_26560356_Chip-Seq_TH2_Human1.04737739
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02511547
65FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02252951
66BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00599748
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95527139
68KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95257126
69CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94631745
70PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91726537
71GATA2_21666600_ChIP-Seq_HMVEC_Human0.90617483
72TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90196719
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89813597
74MYB_26560356_Chip-Seq_TH1_Human0.89791392
75RUNX1_22412390_ChIP-Seq_EML_Mouse0.89660497
76GATA3_27048872_Chip-Seq_THYMUS_Human0.84251949
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.84038035
78JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81718935
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77594471
80JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76194645
81NOTCH1_21737748_ChIP-Seq_TLL_Human0.74401615
82LXR_22158963_ChIP-Seq_LIVER_Mouse0.73105909
83GATA1_19941827_ChIP-Seq_MEL86_Mouse0.72731538
84ELK3_25401928_ChIP-Seq_HUVEC_Human0.72216858
85VDR_21846776_ChIP-Seq_THP-1_Human0.71499770
86BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.69437056
87RXR_22158963_ChIP-Seq_LIVER_Mouse0.68416744
88MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.67939399
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.66999110
90SOX2_20726797_ChIP-Seq_SW620_Human0.66882884
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66652541
92KDM2B_26808549_Chip-Seq_DND41_Human0.66145079
93BCL6_27268052_Chip-Seq_Bcells_Human0.60846501
94MAF_26560356_Chip-Seq_TH2_Human0.60828174
95PPARA_22158963_ChIP-Seq_LIVER_Mouse0.60141086
96NFIB_24661679_ChIP-Seq_LUNG_Mouse0.59445381
97PU.1_20513432_ChIP-Seq_Bcells_Mouse0.59385470
98TCF7_22412390_ChIP-Seq_EML_Mouse0.58849030
99GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.57443387
100STAT3_1855785_ChIP-Seq_MESCs_Mouse0.57237165

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation6.51575505
2MP0005451_abnormal_body_composition4.70796744
3MP0003724_increased_susceptibility_to3.98473888
4MP0002148_abnormal_hypersensitivity_rea3.86243093
5MP0009785_altered_susceptibility_to3.62605932
6MP0006082_CNS_inflammation3.48179935
7MP0001835_abnormal_antigen_presentation3.46820015
8MP0004510_myositis3.17848302
9MP0003436_decreased_susceptibility_to3.01026714
10MP0001790_abnormal_immune_system2.92151189
11MP0005387_immune_system_phenotype2.92151189
12MP0005000_abnormal_immune_tolerance2.79400733
13MP0005671_abnormal_response_to2.77165535
14MP0000685_abnormal_immune_system2.59148832
15MP0005025_abnormal_response_to2.50716479
16MP0003195_calcinosis2.36601608
17MP0001800_abnormal_humoral_immune2.34122344
18MP0009764_decreased_sensitivity_to2.34033646
19MP0002419_abnormal_innate_immunity2.28771392
20MP0002723_abnormal_immune_serum2.25989496
21MP0002452_abnormal_antigen_presenting2.25470747
22MP0003300_gastrointestinal_ulcer2.25113151
23MP0002332_abnormal_exercise_endurance2.09443164
24MP0004947_skin_inflammation2.07030234
25MP0005058_abnormal_lysosome_morphology2.04785045
26MP0010155_abnormal_intestine_physiology2.00153322
27MP0003075_altered_response_to1.96408095
28MP0008004_abnormal_stomach_pH1.95796987
29MP0001533_abnormal_skeleton_physiology1.94816607
30MP0001845_abnormal_inflammatory_respons1.81926004
31MP0002139_abnormal_hepatobiliary_system1.78534762
32MP0009840_abnormal_foam_cell1.75640775
33MP0009278_abnormal_bone_marrow1.73819972
34MP0001819_abnormal_immune_cell1.73725877
35MP0005167_abnormal_blood-brain_barrier1.72743930
36MP0002254_reproductive_system_inflammat1.71508417
37MP0008469_abnormal_protein_level1.68913559
38MP0002420_abnormal_adaptive_immunity1.68167613
39MP0000343_altered_response_to1.56412252
40MP0002405_respiratory_system_inflammati1.53383294
41MP0001853_heart_inflammation1.49111536
42MP0005310_abnormal_salivary_gland1.47781028
43MP0003646_muscle_fatigue1.46595083
44MP0003448_altered_tumor_morphology1.45779398
45MP0003453_abnormal_keratinocyte_physiol1.41310836
46MP0005397_hematopoietic_system_phenotyp1.41210014
47MP0001545_abnormal_hematopoietic_system1.41210014
48MP0006054_spinal_hemorrhage1.31870880
49MP0003690_abnormal_glial_cell1.28789026
50MP0009333_abnormal_splenocyte_physiolog1.26013159
51MP0000716_abnormal_immune_system1.23324386
52MP0003172_abnormal_lysosome_physiology1.22378602
53MP0005166_decreased_susceptibility_to1.16349020
54MP0002138_abnormal_hepatobiliary_system1.08869294
55MP0009763_increased_sensitivity_to1.07839912
56MP0009765_abnormal_xenobiotic_induced1.06324154
57MP0000604_amyloidosis1.03675493
58MP0001501_abnormal_sleep_pattern1.02958523
59MP0002998_abnormal_bone_remodeling0.98574104
60MP0002398_abnormal_bone_marrow0.95604005
61MP0000858_altered_metastatic_potential0.95313228
62MP0005164_abnormal_response_to0.94005271
63MP0003656_abnormal_erythrocyte_physiolo0.89973867
64MP0002429_abnormal_blood_cell0.87981362
65MP0003091_abnormal_cell_migration0.87646748
66MP0003806_abnormal_nucleotide_metabolis0.86948236
67MP0001663_abnormal_digestive_system0.85629724
68MP0005535_abnormal_body_temperature0.80785181
69MP0001542_abnormal_bone_strength0.78184547
70MP0002877_abnormal_melanocyte_morpholog0.78067209
71MP0005464_abnormal_platelet_physiology0.77253409
72MP0002722_abnormal_immune_system0.77165907
73MP0005390_skeleton_phenotype0.76219889
74MP0003191_abnormal_cellular_cholesterol0.75261106
75MP0000689_abnormal_spleen_morphology0.75179635
76MP0005266_abnormal_metabolism0.72681589
77MP0005165_increased_susceptibility_to0.72531889
78MP0002163_abnormal_gland_morphology0.72073420
79MP0002693_abnormal_pancreas_physiology0.70920241
80MP0000920_abnormal_myelination0.63099279
81MP0008874_decreased_physiological_sensi0.62249421
82MP0004808_abnormal_hematopoietic_stem0.61016708
83MP0003183_abnormal_peptide_metabolism0.58435450
84MP0010352_gastrointestinal_tract_polyps0.57331974
85MP0002933_joint_inflammation0.57283890
86MP0001348_abnormal_lacrimal_gland0.57131566
87MP0010307_abnormal_tumor_latency0.55977980
88MP0003763_abnormal_thymus_physiology0.55466659
89MP0005595_abnormal_vascular_smooth0.54344661
90MP0005647_abnormal_sex_gland0.53843321
91MP0000678_abnormal_parathyroid_gland0.53119130
92MP0001873_stomach_inflammation0.51749883
93MP0000249_abnormal_blood_vessel0.50748804
94MP0002277_abnormal_respiratory_mucosa0.48259588
95MP0005381_digestive/alimentary_phenotyp0.48001916
96MP0004043_abnormal_pH_regulation0.47412819
97MP0005379_endocrine/exocrine_gland_phen0.46683061
98MP0005584_abnormal_enzyme/coenzyme_acti0.46037456
99MP0000371_diluted_coat_color0.45301181
100MP0005023_abnormal_wound_healing0.45220487

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)6.67775646
2Optic neuritis (HP:0100653)6.67775646
3Orchitis (HP:0100796)6.25364437
4Abnormality of liposaccharide metabolism (HP:0010968)5.61397690
5Abnormality of glycosphingolipid metabolism (HP:0004343)5.61397690
6Abnormality of glycolipid metabolism (HP:0010969)5.61397690
7Myositis (HP:0100614)5.29658587
8Stomatitis (HP:0010280)4.82502376
9Keratoconjunctivitis sicca (HP:0001097)4.61672525
10Recurrent bacterial skin infections (HP:0005406)4.23634882
11Keratoconjunctivitis (HP:0001096)4.22806599
12Abnormality of macrophages (HP:0004311)4.15036797
13Gastrointestinal infarctions (HP:0005244)3.95666656
14Vacuolated lymphocytes (HP:0001922)3.95011063
15Gangrene (HP:0100758)3.82399087
16Loss of speech (HP:0002371)3.75897529
17Systemic lupus erythematosus (HP:0002725)3.72533644
18Mutism (HP:0002300)3.70425778
19Autoimmune thrombocytopenia (HP:0001973)3.64715067
20Dysostosis multiplex (HP:0000943)3.60942944
21Recurrent abscess formation (HP:0002722)3.60790088
22Increased IgM level (HP:0003496)3.55930888
23Disinhibition (HP:0000734)3.45813886
24Hematochezia (HP:0002573)3.44897625
25Hemoptysis (HP:0002105)3.40374833
26Mediastinal lymphadenopathy (HP:0100721)3.38528012
27Vasculitis (HP:0002633)3.32098677
28Eczematoid dermatitis (HP:0000976)3.31677573
29Pulmonary infiltrates (HP:0002113)3.23641129
30Increased cerebral lipofuscin (HP:0011813)3.23377938
31Interstitial pulmonary disease (HP:0006530)2.89493175
32Elevated erythrocyte sedimentation rate (HP:0003565)2.87083706
33Mesangial abnormality (HP:0001966)2.83069995
34Arterial thrombosis (HP:0004420)2.80652711
35Flared iliac wings (HP:0002869)2.78556854
36Recurrent viral infections (HP:0004429)2.78038413
37Anorexia (HP:0002039)2.74581123
38Abnormality of polysaccharide metabolism (HP:0011012)2.73764903
39Abnormality of glycosaminoglycan metabolism (HP:0004371)2.73764903
40Abnormality of mucopolysaccharide metabolism (HP:0011020)2.73764903
41Ovoid vertebral bodies (HP:0003300)2.71115921
42Encephalitis (HP:0002383)2.68033663
43Increased serum ferritin (HP:0003281)2.66311091
44Parakeratosis (HP:0001036)2.65337026
4511 pairs of ribs (HP:0000878)2.61428180
46Recurrent fungal infections (HP:0002841)2.59242369
47Cupped ribs (HP:0000887)2.58058520
48T lymphocytopenia (HP:0005403)2.55019598
49Hypergammaglobulinemia (HP:0010702)2.53387543
50Mucopolysacchariduria (HP:0008155)2.52840281
51Urinary glycosaminoglycan excretion (HP:0003541)2.52840281
52Abnormality of the pericardium (HP:0001697)2.52231873
53Autoimmune hemolytic anemia (HP:0001890)2.50833318
54Joint swelling (HP:0001386)2.48990216
55Amyloidosis (HP:0011034)2.48902549
56Gingivitis (HP:0000230)2.48359888
57Nuclear cataract (HP:0100018)2.48302100
58Abnormality of T cell number (HP:0011839)2.47303259
59Neurofibrillary tangles (HP:0002185)2.45798939
60Amaurosis fugax (HP:0100576)2.43184126
61Polyneuropathy (HP:0001271)2.42065436
62Vertigo (HP:0002321)2.37739627
63Abnormality of the pleura (HP:0002103)2.37013331
64Increased neuronal autofluorescent lipopigment (HP:0002074)2.36942444
65Abnormality of the endocardium (HP:0004306)2.36911325
66Short nail (HP:0001799)2.35868739
67Glomerulonephritis (HP:0000099)2.34235596
68Inappropriate behavior (HP:0000719)2.33439692
69Progressive neurologic deterioration (HP:0002344)2.33303859
70Broad distal phalanx of finger (HP:0009836)2.28326299
71Recurrent skin infections (HP:0001581)2.27044048
72Apathy (HP:0000741)2.26810381
73Recurrent gram-negative bacterial infections (HP:0005420)2.26007174
74Episodic fever (HP:0001954)2.24184683
75Abnormality of B cell number (HP:0010975)2.20981584
76Increased IgE level (HP:0003212)2.19061366
77Diminished motivation (HP:0000745)2.18497273
78Chronic otitis media (HP:0000389)2.17877837
79Spastic tetraparesis (HP:0001285)2.17243001
80IgA deficiency (HP:0002720)2.14791593
81Acne (HP:0001061)2.10830274
82Keratitis (HP:0000491)2.10557627
83Basal ganglia calcification (HP:0002135)2.09607501
84Memory impairment (HP:0002354)2.09367985
85Leukocytosis (HP:0001974)2.06929916
86Abnormality of iron homeostasis (HP:0011031)2.05963107
87Myocardial infarction (HP:0001658)2.03917416
88Nausea (HP:0002018)2.02156925
89Meningitis (HP:0001287)2.02016352
90Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.01442503
91Arthralgia (HP:0002829)1.99749809
92Colitis (HP:0002583)1.99742797
93Pulmonary embolism (HP:0002204)1.99676116
94Global brain atrophy (HP:0002283)1.98145025
95B lymphocytopenia (HP:0010976)1.98015651
96Hypertensive crisis (HP:0100735)1.95848281
97Pathologic fracture (HP:0002756)1.91000178
98Coxa valga (HP:0002673)1.88734983
99Urticaria (HP:0001025)1.88689566
100Agnosia (HP:0010524)1.87627210

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK35.61522736
2GRK74.26646430
3RIPK13.51023492
4MAP3K143.43772924
5ADRBK23.43441404
6MATK3.08688972
7DDR22.96006427
8TYK22.87470196
9IRAK42.63730648
10TBK12.61796252
11TAOK22.49572569
12IKBKE2.45194063
13IKBKB2.25785064
14PRPF4B2.17200283
15JAK32.13411199
16RIPK42.08537059
17PIM22.01335507
18TXK1.93815730
19NME21.90966579
20FGR1.83144151
21BMPR21.78965061
22MAP4K11.72641362
23MOS1.71856247
24CSK1.65468380
25ACVR1B1.62383525
26IRAK11.62075700
27CHUK1.57971386
28JAK11.56020836
29BLK1.53551321
30CDC42BPA1.49100842
31MAP3K111.46289360
32TAOK11.33788956
33EPHA31.23047893
34CLK11.22130623
35TYRO31.19734200
36MAP3K31.19728413
37JAK21.13991884
38DAPK21.13242037
39ZAP701.11552237
40MAP3K11.11416774
41IRAK21.08293649
42LATS20.98597520
43KSR20.97757759
44TGFBR20.97476747
45PKN10.93708709
46MAP2K30.92986920
47LYN0.89839028
48MAP3K130.84286855
49SYK0.84227717
50FGFR40.78590059
51MAP3K50.73651115
52LCK0.70716778
53KIT0.70278468
54STK100.66274818
55PIM10.61975116
56ERN10.60223522
57SIK20.58426429
58HIPK20.55869527
59DYRK30.52926447
60TLK10.52805246
61SIK30.52032320
62KSR10.51395679
63MARK30.51088731
64PDGFRA0.50724695
65ABL20.50485979
66CSF1R0.48539926
67CDK60.47661108
68CDK40.47435868
69TAOK30.45841445
70MAP2K60.43755305
71HCK0.42549563
72PAK60.37426276
73NTRK30.36795669
74PDGFRB0.36760433
75BTK0.36523067
76EPHB10.36477121
77BMX0.34643553
78FGFR30.33997241
79MAP3K20.31540259
80NEK90.30784124
81INSR0.30749465
82EGFR0.27175442
83MAPK40.26384011
84TGFBR10.23354208
85DAPK30.23255176
86ABL10.23195297
87ICK0.21531020
88PDK10.21440839
89MAP3K90.19992816
90RAF10.19137031
91PRKCD0.16310012
92MARK20.13841415
93EIF2AK20.13584759
94MELK0.12678577
95STK240.11890871
96MAP3K80.11317460
97PDPK10.10607925
98WNK10.10539640
99PRKCQ0.10531368
100MAPK30.10459229

Predicted pathways (KEGG)

RankGene SetZ-score
1Toll-like receptor signaling pathway_Homo sapiens_hsa046203.51095791
2Allograft rejection_Homo sapiens_hsa053303.39073586
3African trypanosomiasis_Homo sapiens_hsa051433.04914681
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.97847299
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.77343133
6Asthma_Homo sapiens_hsa053102.71303885
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.71179905
8Graft-versus-host disease_Homo sapiens_hsa053322.66821027
9Leishmaniasis_Homo sapiens_hsa051402.52569459
10NOD-like receptor signaling pathway_Homo sapiens_hsa046212.50106484
11TNF signaling pathway_Homo sapiens_hsa046682.47900625
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.43141080
13Autoimmune thyroid disease_Homo sapiens_hsa053202.42952361
14Osteoclast differentiation_Homo sapiens_hsa043802.42791836
15Rheumatoid arthritis_Homo sapiens_hsa053232.33732740
16Pertussis_Homo sapiens_hsa051332.24202059
17Type I diabetes mellitus_Homo sapiens_hsa049402.23511428
18Malaria_Homo sapiens_hsa051442.23155738
19Staphylococcus aureus infection_Homo sapiens_hsa051502.19124934
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.16368311
21Legionellosis_Homo sapiens_hsa051342.09488059
22Influenza A_Homo sapiens_hsa051641.93797671
23Tuberculosis_Homo sapiens_hsa051521.85490839
24Other glycan degradation_Homo sapiens_hsa005111.80467959
25Toxoplasmosis_Homo sapiens_hsa051451.76190850
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.72486072
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.70481804
28Lysosome_Homo sapiens_hsa041421.62191632
29Measles_Homo sapiens_hsa051621.59080150
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.56317631
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.51073373
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.47470129
33Herpes simplex infection_Homo sapiens_hsa051681.43216052
34Salmonella infection_Homo sapiens_hsa051321.34344894
35Chemokine signaling pathway_Homo sapiens_hsa040621.29728702
36Hepatitis C_Homo sapiens_hsa051601.27435657
37Antigen processing and presentation_Homo sapiens_hsa046121.23518967
38Viral myocarditis_Homo sapiens_hsa054161.22523471
39Hematopoietic cell lineage_Homo sapiens_hsa046401.16292319
40Prion diseases_Homo sapiens_hsa050201.05516225
41Tryptophan metabolism_Homo sapiens_hsa003801.04989244
42Hepatitis B_Homo sapiens_hsa051611.04211400
43Primary immunodeficiency_Homo sapiens_hsa053401.04080602
44B cell receptor signaling pathway_Homo sapiens_hsa046620.98744686
45Glycosaminoglycan degradation_Homo sapiens_hsa005310.98217114
46Adipocytokine signaling pathway_Homo sapiens_hsa049200.94989760
47Prolactin signaling pathway_Homo sapiens_hsa049170.91662323
48Apoptosis_Homo sapiens_hsa042100.84763029
49Bladder cancer_Homo sapiens_hsa052190.84384568
50Shigellosis_Homo sapiens_hsa051310.83882899
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80891714
52Amoebiasis_Homo sapiens_hsa051460.80582731
53Phagosome_Homo sapiens_hsa041450.78686203
54Acute myeloid leukemia_Homo sapiens_hsa052210.75893224
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74233148
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72157783
57Type II diabetes mellitus_Homo sapiens_hsa049300.70975977
58Epstein-Barr virus infection_Homo sapiens_hsa051690.69777794
59T cell receptor signaling pathway_Homo sapiens_hsa046600.69688510
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69567085
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67661519
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62517740
63Sulfur metabolism_Homo sapiens_hsa009200.61065923
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55827368
65Sphingolipid metabolism_Homo sapiens_hsa006000.55792647
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51773666
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49867363
68VEGF signaling pathway_Homo sapiens_hsa043700.44953714
69Mineral absorption_Homo sapiens_hsa049780.44685836
70Dorso-ventral axis formation_Homo sapiens_hsa043200.41641943
71Selenocompound metabolism_Homo sapiens_hsa004500.34486795
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34217526
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.29837557
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28801722
75Systemic lupus erythematosus_Homo sapiens_hsa053220.28219157
76HTLV-I infection_Homo sapiens_hsa051660.27390346
77Insulin resistance_Homo sapiens_hsa049310.27304497
78ABC transporters_Homo sapiens_hsa020100.26297095
79Complement and coagulation cascades_Homo sapiens_hsa046100.25939010
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.25768580
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.21942870
82FoxO signaling pathway_Homo sapiens_hsa040680.21766472
83Viral carcinogenesis_Homo sapiens_hsa052030.20977389
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19898195
85HIF-1 signaling pathway_Homo sapiens_hsa040660.19877877
86MAPK signaling pathway_Homo sapiens_hsa040100.17821257
87Ether lipid metabolism_Homo sapiens_hsa005650.15953948
88Folate biosynthesis_Homo sapiens_hsa007900.13184543
89Pancreatic cancer_Homo sapiens_hsa052120.11880764
90Collecting duct acid secretion_Homo sapiens_hsa049660.10748900
91Chronic myeloid leukemia_Homo sapiens_hsa052200.09786071
92Notch signaling pathway_Homo sapiens_hsa043300.08261950
93Small cell lung cancer_Homo sapiens_hsa052220.04756133
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.04041234
95PPAR signaling pathway_Homo sapiens_hsa033200.02966978
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.02827288
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760-0.0088040
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0067913
99alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0045615
100Endocytosis_Homo sapiens_hsa04144-0.0003637

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