GPR25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is intronless and encodes a member of the G-protein coupled receptor 1 family. G-protein coupled receptors are membrane proteins which activate signaling cascades as a response to extracellular stress. This gene has been linked to arterial stiffness. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.85678663
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.44664163
3antigen processing and presentation of endogenous antigen (GO:0019883)6.27145608
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.95433478
5V(D)J recombination (GO:0033151)5.45785137
6synaptic vesicle maturation (GO:0016188)5.26378183
7regulation of B cell receptor signaling pathway (GO:0050855)5.24408476
8leukocyte aggregation (GO:0070486)4.91111712
9locomotory exploration behavior (GO:0035641)4.82890283
10signal complex assembly (GO:0007172)4.79544893
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.75274820
12detection of bacterium (GO:0016045)4.70573949
13regulation of short-term neuronal synaptic plasticity (GO:0048172)4.70434481
14detection of other organism (GO:0098543)4.57697509
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.57107024
16T cell migration (GO:0072678)4.53466128
17neutrophil activation involved in immune response (GO:0002283)4.52516623
18tolerance induction (GO:0002507)4.47377602
19modulation by symbiont of host defense response (GO:0052031)4.42772197
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.42772197
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.42772197
22positive regulation by organism of defense response of other organism involved in symbiotic interact4.42772197
23modulation by symbiont of host immune response (GO:0052553)4.42772197
24positive regulation by symbiont of host defense response (GO:0052509)4.42772197
25synaptic vesicle exocytosis (GO:0016079)4.37754001
26negative regulation of lymphocyte mediated immunity (GO:0002707)4.37563617
27vocalization behavior (GO:0071625)4.26521339
28immunoglobulin mediated immune response (GO:0016064)4.23106241
29positive T cell selection (GO:0043368)4.22777194
30layer formation in cerebral cortex (GO:0021819)4.21211185
31regulation of glutamate receptor signaling pathway (GO:1900449)4.21154255
32regulation of T cell tolerance induction (GO:0002664)4.19689193
33positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.17883161
34B cell receptor signaling pathway (GO:0050853)4.14410179
35negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.11388604
36negative regulation of cell killing (GO:0031342)4.11388604
37glutamate secretion (GO:0014047)4.09780244
38positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.09669789
39G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.07302774
40cellular extravasation (GO:0045123)4.06729913
41positive regulation of gamma-delta T cell activation (GO:0046645)4.01406324
42exploration behavior (GO:0035640)4.00647542
43negative regulation of T cell mediated immunity (GO:0002710)3.96123478
44regulation of gamma-delta T cell differentiation (GO:0045586)3.92123436
45positive regulation of B cell differentiation (GO:0045579)3.90607294
46positive regulation of synapse maturation (GO:0090129)3.89701321
47regulation of alpha-beta T cell proliferation (GO:0046640)3.87048167
48regulation of synaptic vesicle exocytosis (GO:2000300)3.80430556
49negative regulation of leukocyte mediated immunity (GO:0002704)3.79861646
50negative regulation of phagocytosis (GO:0050765)3.78577074
51positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.78458283
52type I interferon signaling pathway (GO:0060337)3.78017668
53cellular response to type I interferon (GO:0071357)3.78017668
54regulation of neuronal synaptic plasticity (GO:0048168)3.77824370
55regulation of long-term neuronal synaptic plasticity (GO:0048169)3.76487018
56positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.74732365
57regulation of B cell differentiation (GO:0045577)3.74627759
58response to type I interferon (GO:0034340)3.73762754
59negative T cell selection (GO:0043383)3.71590152
60regulation of regulatory T cell differentiation (GO:0045589)3.69283319
61regulation of tolerance induction (GO:0002643)3.68208756
62regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.67882373
63protein localization to synapse (GO:0035418)3.65756286
64respiratory burst (GO:0045730)3.64665757
65synaptic vesicle docking involved in exocytosis (GO:0016081)3.60851066
66macrophage activation involved in immune response (GO:0002281)3.60471289
67neutrophil activation (GO:0042119)3.53139635
68sodium ion export (GO:0071436)3.50321191
69regulation of T cell mediated cytotoxicity (GO:0001914)3.48281382
70dendritic spine morphogenesis (GO:0060997)3.48031737
71positive regulation of T cell mediated cytotoxicity (GO:0001916)3.47882906
72positive regulation of dendritic spine morphogenesis (GO:0061003)3.47569382
73regulation of natural killer cell mediated immunity (GO:0002715)3.46970714
74regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.46970714
75neurotransmitter secretion (GO:0007269)3.46622570
76regulation of dendritic cell antigen processing and presentation (GO:0002604)3.42900193
77T cell selection (GO:0045058)3.40718599
78interferon-gamma-mediated signaling pathway (GO:0060333)3.38959874
79B cell mediated immunity (GO:0019724)3.38176267
80regulation of gamma-delta T cell activation (GO:0046643)3.37236324
81neutrophil mediated immunity (GO:0002446)3.36585111
82detection of external biotic stimulus (GO:0098581)3.34752183
83positive regulation of alpha-beta T cell proliferation (GO:0046641)3.33394776
84negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.31901152
85myeloid dendritic cell differentiation (GO:0043011)3.29879566
86regulation of interferon-beta biosynthetic process (GO:0045357)3.27851266
87regulation of dendritic spine morphogenesis (GO:0061001)3.27275306
88regulation of NFAT protein import into nucleus (GO:0051532)3.26549863
89T cell receptor signaling pathway (GO:0050852)3.25816916
90ionotropic glutamate receptor signaling pathway (GO:0035235)3.24936694
91regulation of synaptic vesicle transport (GO:1902803)3.24581896
92regulation of interleukin-2 biosynthetic process (GO:0045076)3.23772501
93myeloid dendritic cell activation (GO:0001773)3.20603298
94positive regulation of tolerance induction (GO:0002645)3.20110281
95NIK/NF-kappaB signaling (GO:0038061)3.19188750
96negative regulation of interleukin-12 production (GO:0032695)3.18615333
97activation of protein kinase A activity (GO:0034199)3.17886368
98positive regulation of humoral immune response (GO:0002922)3.16128802
99myeloid cell activation involved in immune response (GO:0002275)3.15308143
100granulocyte activation (GO:0036230)3.15276537
101response to peptidoglycan (GO:0032494)3.14685325
102positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.14274365
103gamma-aminobutyric acid transport (GO:0015812)3.14242152
104antigen processing and presentation via MHC class Ib (GO:0002475)3.14094971
105neurotransmitter-gated ion channel clustering (GO:0072578)3.11985759
106regulation of synapse structural plasticity (GO:0051823)3.11064066
107regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.10787631
108T cell homeostasis (GO:0043029)3.10548071
109clathrin coat assembly (GO:0048268)3.09712167
110neuron cell-cell adhesion (GO:0007158)3.08956244
111mast cell degranulation (GO:0043303)3.08661950
112mast cell activation involved in immune response (GO:0002279)3.08661950
113lymphocyte homeostasis (GO:0002260)3.08463474
114cellular potassium ion homeostasis (GO:0030007)3.08358315
115regulation of ARF GTPase activity (GO:0032312)3.06172161
116positive regulation of membrane potential (GO:0045838)3.05465085
117negative regulation of microtubule polymerization (GO:0031115)3.05301143
118regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.03630272
119negative regulation of erythrocyte differentiation (GO:0045647)3.03470466
120leukocyte degranulation (GO:0043299)3.03303781
121synaptic vesicle endocytosis (GO:0048488)3.03065360
122lymphocyte migration (GO:0072676)3.03017076
123long-term memory (GO:0007616)3.02808807
124synaptic transmission, glutamatergic (GO:0035249)3.02381848
125glutamate receptor signaling pathway (GO:0007215)3.01502156
126response to muramyl dipeptide (GO:0032495)3.01041240
127B cell homeostasis (GO:0001782)3.00522083
128regulation of excitatory postsynaptic membrane potential (GO:0060079)2.98616697
129regulation of synaptic plasticity (GO:0048167)2.96298919
130regulation of isotype switching to IgG isotypes (GO:0048302)2.96071048
131response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.95771238
132response to host immune response (GO:0052572)2.95771238
133regulation of leukocyte mediated cytotoxicity (GO:0001910)2.95753657
134negative thymic T cell selection (GO:0045060)2.95426285
135response to interleukin-15 (GO:0070672)2.94695260
136neuromuscular process controlling balance (GO:0050885)2.93927508
137defense response to protozoan (GO:0042832)2.93338215
138activated T cell proliferation (GO:0050798)2.89839762
139myeloid leukocyte mediated immunity (GO:0002444)2.89201285
140positive regulation of granulocyte differentiation (GO:0030854)2.89005929
141negative regulation of innate immune response (GO:0045824)2.88791633
142establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.88593201
143mitochondrion transport along microtubule (GO:0047497)2.88593201
144regulation of antigen processing and presentation (GO:0002577)2.88181871
145detection of biotic stimulus (GO:0009595)2.88157710
146positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.87788787
147regulation of Rap GTPase activity (GO:0032317)2.87441958
148adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.87135060
149positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.83968528
150Peyers patch development (GO:0048541)2.82949029
151mucosal-associated lymphoid tissue development (GO:0048537)2.82949029
152positive regulation of Rap GTPase activity (GO:0032854)2.81692628
153neuron-neuron synaptic transmission (GO:0007270)2.80522588
154thymic T cell selection (GO:0045061)2.78660754
155nerve growth factor signaling pathway (GO:0038180)2.78005077
156cerebellar granule cell differentiation (GO:0021707)2.77406637
157regulation of ARF protein signal transduction (GO:0032012)2.72850920
158regulation of postsynaptic membrane potential (GO:0060078)2.71966237
159positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.69981703
160proline transport (GO:0015824)2.69189794
161dopamine receptor signaling pathway (GO:0007212)2.68963937
162regulation of dendritic spine development (GO:0060998)2.68661354
163regulation of defense response to virus by virus (GO:0050690)2.62381015
164positive regulation of dendritic spine development (GO:0060999)2.60672510
165antigen receptor-mediated signaling pathway (GO:0050851)2.60170622
166neuronal action potential propagation (GO:0019227)2.59284080
167mast cell activation (GO:0045576)2.57671510
168regulation of synapse maturation (GO:0090128)2.57664762
169positive thymic T cell selection (GO:0045059)2.57342978
170negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.55296534
171T cell costimulation (GO:0031295)2.54181692
172nucleosome disassembly (GO:0006337)2.53850232
173protein-DNA complex disassembly (GO:0032986)2.53850232
174DNA unwinding involved in DNA replication (GO:0006268)2.53765120
175establishment of mitochondrion localization (GO:0051654)2.53006562
176auditory behavior (GO:0031223)2.52764313
177histone H4-K12 acetylation (GO:0043983)2.52118820
178cellular response to interleukin-15 (GO:0071350)2.51148298
179lymphocyte costimulation (GO:0031294)2.50601169
180regulation of neurotransmitter levels (GO:0001505)2.50056037
181positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.49786767
182negative regulation of RNA splicing (GO:0033119)2.48075917

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.24803773
2MYC_22102868_ChIP-Seq_BL_Human4.13709179
3E2F7_22180533_ChIP-Seq_HELA_Human3.68602058
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.64078666
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.30111091
6RARB_27405468_Chip-Seq_BRAIN_Mouse3.21708979
7EZH2_22144423_ChIP-Seq_EOC_Human3.20733974
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.14640325
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.10226147
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.06369214
11KDM2B_26808549_Chip-Seq_DND41_Human2.94047893
12VDR_21846776_ChIP-Seq_THP-1_Human2.92397518
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.91997000
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.91338344
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.74809405
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.74045377
17KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.68180920
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.66979719
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.66300427
20TCF7_22412390_ChIP-Seq_EML_Mouse2.58542904
21DROSHA_22980978_ChIP-Seq_HELA_Human2.55414558
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.48851974
23ZFP281_18757296_ChIP-ChIP_E14_Mouse2.47077820
24SPI1_23547873_ChIP-Seq_NB4_Human2.44681886
25KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.42230976
26IRF8_27001747_Chip-Seq_BMDM_Mouse2.35857212
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.34365952
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.33144811
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32092964
30REST_21632747_ChIP-Seq_MESCs_Mouse2.30308858
31LXR_22292898_ChIP-Seq_THP-1_Human2.25517912
32MYB_21317192_ChIP-Seq_ERMYB_Mouse2.25389432
33DNAJC2_21179169_ChIP-ChIP_NT2_Human2.17575575
34ZFP281_27345836_Chip-Seq_ESCs_Mouse2.17349024
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.16447918
36BRD4_27068464_Chip-Seq_AML-cells_Mouse2.13323739
37KDM2B_26808549_Chip-Seq_JURKAT_Human2.10885411
38REST_18959480_ChIP-ChIP_MESCs_Mouse2.10330813
39FOXM1_23109430_ChIP-Seq_U2OS_Human2.10238998
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.03040634
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.00095031
42UTX_26944678_Chip-Seq_JUKART_Human1.98060182
43KDM2B_26808549_Chip-Seq_K562_Human1.93061316
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.90995484
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90605759
46AR_21572438_ChIP-Seq_LNCaP_Human1.85686150
47* GATA3_27048872_Chip-Seq_THYMUS_Human1.84875094
48* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.82769764
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.81531134
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79963412
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75777058
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.74987739
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74827054
54MAF_26560356_Chip-Seq_TH1_Human1.74190796
55WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.72099343
56FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.68497351
57VDR_24763502_ChIP-Seq_THP-1_Human1.67870978
58* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.67008594
59GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.65516328
60E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.65043951
61RUNX_20019798_ChIP-Seq_JUKART_Human1.64939978
62DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.60848018
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60075348
64SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.55818925
65RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.54400368
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53388210
67SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.52852369
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49223177
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48330238
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47600987
71FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.45002883
72* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.44350868
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44073225
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.43953007
75SCL_19346495_ChIP-Seq_HPC-7_Human1.42108704
76* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.40561599
77MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40488000
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38627438
79EZH2_18974828_ChIP-Seq_MESCs_Mouse1.38095743
80RNF2_18974828_ChIP-Seq_MESCs_Mouse1.38095743
81* MYB_26560356_Chip-Seq_TH2_Human1.36860989
82* RNF2_27304074_Chip-Seq_ESCs_Mouse1.34613402
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.33172542
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32330256
85SPI1_23127762_ChIP-Seq_K562_Human1.31926328
86GATA2_22383799_ChIP-Seq_G1ME_Mouse1.31577524
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29645493
88* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29114140
89* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27806192
90EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.26649736
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.26396001
92TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25818192
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24908663
94PU.1_20513432_ChIP-Seq_Bcells_Mouse1.24509509
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24491858
96* GATA3_26560356_Chip-Seq_TH2_Human1.23285309
97CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22612043
98BCL6_27268052_Chip-Seq_Bcells_Human1.22257092
99RACK7_27058665_Chip-Seq_MCF-7_Human1.22206289
100CREB1_26743006_Chip-Seq_LNCaP_Human1.21961295
101ELK3_25401928_ChIP-Seq_HUVEC_Human1.21852930
102MAF_26560356_Chip-Seq_TH2_Human1.21298246
103VDR_24787735_ChIP-Seq_THP-1_Human1.20312799
104BCOR_27268052_Chip-Seq_Bcells_Human1.18904397
105SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18394251
106TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.17657974
107EZH2_27294783_Chip-Seq_ESCs_Mouse1.16575994
108* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16372003
109VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14704596
110* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.14289729
111* RING1B_27294783_Chip-Seq_ESCs_Mouse1.11262195
112SMAD_19615063_ChIP-ChIP_OVARY_Human1.10942989
113* PU_27001747_Chip-Seq_BMDM_Mouse1.10925762
114SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10873516
115* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09310368
116* CTCF_27219007_Chip-Seq_Bcells_Human1.07899002
117P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07205013
118SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06249972
119ERG_21242973_ChIP-ChIP_JURKAT_Human1.05849931
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05820600
121CIITA_25753668_ChIP-Seq_RAJI_Human1.05723564
122GATA1_19941826_ChIP-Seq_K562_Human1.04922949
123* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04552193
124RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03941124
125SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03194825
126CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02966351
127P68_20966046_ChIP-Seq_HELA_Human1.02350291
128SMC4_20622854_ChIP-Seq_HELA_Human1.02044399
129TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02011916
130ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01057480
131RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00510986
132MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99642403
133PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99552753
134* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99322987
135SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99145553
136TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98184952
137PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97530446
138SPI1_20517297_ChIP-Seq_HL60_Human0.97055319
139STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96684135
140SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.96308050
141SA1_27219007_Chip-Seq_ERYTHROID_Human0.96192652
142RUNX1_22412390_ChIP-Seq_EML_Mouse0.95752200
143Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93985072
144RING1B_27294783_Chip-Seq_NPCs_Mouse0.93421910
145CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93094652
146RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92851548
147WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91578177
148* NCOR1_26117541_ChIP-Seq_K562_Human0.91459519
149* EZH2_27304074_Chip-Seq_ESCs_Mouse0.91334300
150CTCF_27219007_Chip-Seq_ERYTHROID_Human0.90901816
151MYB_26560356_Chip-Seq_TH1_Human0.90767103
152ELF1_20517297_ChIP-Seq_JURKAT_Human0.90520772
153STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.90436690
154SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.90184076
155PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88478251
156GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84977796
157CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.83225288
158NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.82767350

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.66382255
2MP0003635_abnormal_synaptic_transmissio3.98973313
3MP0003436_decreased_susceptibility_to3.92688805
4MP0001835_abnormal_antigen_presentation3.71666215
5MP0003724_increased_susceptibility_to3.54034593
6MP0003880_abnormal_central_pattern3.41717080
7MP0001790_abnormal_immune_system3.26136521
8MP0005387_immune_system_phenotype3.26136521
9MP0005000_abnormal_immune_tolerance3.15026128
10MP0002063_abnormal_learning/memory/cond3.14138475
11MP0009745_abnormal_behavioral_response2.95388603
12MP0002723_abnormal_immune_serum2.88155060
13MP0005025_abnormal_response_to2.84901110
14MP0002452_abnormal_antigen_presenting2.77071527
15MP0002419_abnormal_innate_immunity2.74634928
16MP0002064_seizures2.74494353
17MP0003763_abnormal_thymus_physiology2.58718932
18MP0004270_analgesia2.52736487
19MP0009785_altered_susceptibility_to2.41948558
20MP0002572_abnormal_emotion/affect_behav2.40790493
21MP0009278_abnormal_bone_marrow2.32887937
22MP0000703_abnormal_thymus_morphology2.26448010
23MP0005423_abnormal_somatic_nervous2.22609945
24MP0002148_abnormal_hypersensitivity_rea2.22363188
25MP0006082_CNS_inflammation2.21131684
26MP0001968_abnormal_touch/_nociception2.13812584
27MP0008569_lethality_at_weaning2.09467090
28MP0002822_catalepsy2.06804633
29MP0005464_abnormal_platelet_physiology2.00154252
30MP0009046_muscle_twitch1.98879782
31MP0003300_gastrointestinal_ulcer1.94266251
32MP0004947_skin_inflammation1.93003774
33MP0000465_gastrointestinal_hemorrhage1.90682578
34MP0003183_abnormal_peptide_metabolism1.90293874
35MP0004811_abnormal_neuron_physiology1.83037477
36MP0001873_stomach_inflammation1.82016921
37MP0002733_abnormal_thermal_nociception1.78935077
38MP0001845_abnormal_inflammatory_respons1.75878160
39MP0001533_abnormal_skeleton_physiology1.75830307
40MP0002272_abnormal_nervous_system1.74557605
41MP0003329_amyloid_beta_deposits1.73987892
42MP0004381_abnormal_hair_follicle1.71680082
43MP0003787_abnormal_imprinting1.68168284
44MP0001970_abnormal_pain_threshold1.67548734
45MP0001486_abnormal_startle_reflex1.62286572
46MP0002735_abnormal_chemical_nociception1.56947912
47MP0005386_behavior/neurological_phenoty1.56806857
48MP0004924_abnormal_behavior1.56806857
49MP0003303_peritoneal_inflammation1.54821828
50MP0005076_abnormal_cell_differentiation1.51325628
51MP0008961_abnormal_basal_metabolism1.46814550
52MP0008260_abnormal_autophagy1.46684709
53MP0002132_abnormal_respiratory_system1.45235949
54MP0002398_abnormal_bone_marrow1.44925444
55MP0004858_abnormal_nervous_system1.42927862
56MP0002734_abnormal_mechanical_nocicepti1.42278816
57MP0001851_eye_inflammation1.40406031
58MP0005409_darkened_coat_color1.39763024
59MP0002736_abnormal_nociception_after1.38488079
60MP0000778_abnormal_nervous_system1.37912759
61MP0008877_abnormal_DNA_methylation1.37068347
62MP0005397_hematopoietic_system_phenotyp1.35650590
63MP0001545_abnormal_hematopoietic_system1.35650590
64MP0002009_preneoplasia1.34991667
65MP0002396_abnormal_hematopoietic_system1.34710211
66MP0008469_abnormal_protein_level1.33770131
67MP0003866_abnormal_defecation1.33286973
68MP0005645_abnormal_hypothalamus_physiol1.33280287
69MP0002557_abnormal_social/conspecific_i1.32448101
70MP0002067_abnormal_sensory_capabilities1.32432200
71MP0002277_abnormal_respiratory_mucosa1.32058448
72MP0002184_abnormal_innervation1.31740595
73MP0008874_decreased_physiological_sensi1.30027998
74MP0000955_abnormal_spinal_cord1.28539931
75MP0003633_abnormal_nervous_system1.27482704
76MP0000490_abnormal_crypts_of1.27288040
77MP0005451_abnormal_body_composition1.26296083
78MP0004510_myositis1.23947222
79MP0002909_abnormal_adrenal_gland1.22293543
80MP0003191_abnormal_cellular_cholesterol1.18871763
81MP0009780_abnormal_chondrocyte_physiolo1.18589998
82MP0002722_abnormal_immune_system1.18485556
83MP0005174_abnormal_tail_pigmentation1.18374826
84MP0003879_abnormal_hair_cell1.17284106
85MP0001440_abnormal_grooming_behavior1.16976863
86MP0000685_abnormal_immune_system1.16963475
87MP0005075_abnormal_melanosome_morpholog1.16810000
88MP0001501_abnormal_sleep_pattern1.16059486
89MP0002066_abnormal_motor_capabilities/c1.15721960
90MP0003075_altered_response_to1.14444111
91MP0000858_altered_metastatic_potential1.13523308
92MP0002933_joint_inflammation1.11768541
93MP0005671_abnormal_response_to1.10790252
94MP0003172_abnormal_lysosome_physiology1.09849829
95MP0008770_decreased_survivor_rate1.08755903
96MP0000015_abnormal_ear_pigmentation1.08465882
97MP0002882_abnormal_neuron_morphology1.06069307
98MP0002998_abnormal_bone_remodeling1.04795158
99MP0000716_abnormal_immune_system1.03024626
100MP0002152_abnormal_brain_morphology1.02492853
101MP0003828_pulmonary_edema1.02364693
102MP0003631_nervous_system_phenotype1.01309194
103MP0002138_abnormal_hepatobiliary_system1.01227526
104MP0000013_abnormal_adipose_tissue1.00504397
105MP0010234_abnormal_vibrissa_follicle1.00397484
106MP0004808_abnormal_hematopoietic_stem0.99219941
107MP0002166_altered_tumor_susceptibility0.95686352
108MP0008872_abnormal_physiological_respon0.95358161
109MP0005058_abnormal_lysosome_morphology0.94768021
110MP0001663_abnormal_digestive_system0.92635982
111MP0010094_abnormal_chromosome_stability0.92333398
112MP0004883_abnormal_blood_vessel0.90881533
113MP0002163_abnormal_gland_morphology0.88933225
114MP0010352_gastrointestinal_tract_polyps0.88001911
115MP0000689_abnormal_spleen_morphology0.87749182
116MP0002006_tumorigenesis0.87549536
117MP0001529_abnormal_vocalization0.83996831
118MP0009333_abnormal_splenocyte_physiolog0.82532128
119MP0004130_abnormal_muscle_cell0.82472516
120MP0002420_abnormal_adaptive_immunity0.82443649
121MP0009764_decreased_sensitivity_to0.80825859
122MP0001819_abnormal_immune_cell0.80229537
123MP0002405_respiratory_system_inflammati0.79995363
124MP0001853_heart_inflammation0.79872656
125MP0005310_abnormal_salivary_gland0.79689817
126MP0005499_abnormal_olfactory_system0.79267741
127MP0005394_taste/olfaction_phenotype0.79267741
128MP0010769_abnormal_survival0.78845149
129MP0003091_abnormal_cell_migration0.78471503
130MP0005390_skeleton_phenotype0.77693653
131MP0003045_fibrosis0.76287033
132MP0010768_mortality/aging0.75828477
133MP0002069_abnormal_eating/drinking_beha0.75542260
134MP0004885_abnormal_endolymph0.75126461
135MP0002429_abnormal_blood_cell0.75093064
136MP0005166_decreased_susceptibility_to0.74335709
137MP0002928_abnormal_bile_duct0.73337424
138MP0001905_abnormal_dopamine_level0.73121396
139MP0002083_premature_death0.71333815
140MP0009763_increased_sensitivity_to0.71250626
141MP0010770_preweaning_lethality0.70427033
142MP0002082_postnatal_lethality0.70427033
143MP0008057_abnormal_DNA_replication0.69820120
144MP0001849_ear_inflammation0.69043806
145MP0001348_abnormal_lacrimal_gland0.68313948
146MP0002019_abnormal_tumor_incidence0.67760366
147MP0003861_abnormal_nervous_system0.67488240
148MP0010155_abnormal_intestine_physiology0.66835757
149MP0001800_abnormal_humoral_immune0.66334491
150MP0003448_altered_tumor_morphology0.65265173
151MP0000249_abnormal_blood_vessel0.62771973
152MP0002653_abnormal_ependyma_morphology0.60180496
153MP0001986_abnormal_taste_sensitivity0.58777657
154MP0005164_abnormal_response_to0.55773595
155MP0000604_amyloidosis0.55703899
156MP0002693_abnormal_pancreas_physiology0.55230017
157MP0003795_abnormal_bone_structure0.54285848
158MP0005381_digestive/alimentary_phenotyp0.51605395
159MP0009765_abnormal_xenobiotic_induced0.46308943
160MP0003690_abnormal_glial_cell0.45685313
161MP0002133_abnormal_respiratory_system0.44301066
162MP0005388_respiratory_system_phenotype0.44301066
163MP0003878_abnormal_ear_physiology0.42888751
164MP0005377_hearing/vestibular/ear_phenot0.42888751

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.76364106
2Recurrent bacterial skin infections (HP:0005406)5.89650095
3Recurrent abscess formation (HP:0002722)5.67782037
4Myositis (HP:0100614)5.15689938
5Elevated erythrocyte sedimentation rate (HP:0003565)5.07964818
6Myokymia (HP:0002411)4.97890639
7Abnormality of macrophages (HP:0004311)4.85102946
8Stomatitis (HP:0010280)4.80422193
9Focal motor seizures (HP:0011153)4.72535545
10Recurrent gram-negative bacterial infections (HP:0005420)4.44087229
11Meningitis (HP:0001287)4.42801267
12Visual hallucinations (HP:0002367)4.41401394
13T lymphocytopenia (HP:0005403)4.20207690
14Mediastinal lymphadenopathy (HP:0100721)4.18608011
15Orchitis (HP:0100796)4.04862897
16Gastrointestinal infarctions (HP:0005244)4.03145757
17Vasculitis (HP:0002633)3.92792429
18Retrobulbar optic neuritis (HP:0100654)3.92650228
19Optic neuritis (HP:0100653)3.92650228
20Abnormality of T cell number (HP:0011839)3.85703570
21Gastrointestinal stroma tumor (HP:0100723)3.83481598
22Obstructive lung disease (HP:0006536)3.82446106
23Chronic obstructive pulmonary disease (HP:0006510)3.82446106
24Recurrent skin infections (HP:0001581)3.82063779
25Lymphopenia (HP:0001888)3.78753426
26Pustule (HP:0200039)3.77907413
27Increased IgE level (HP:0003212)3.76084385
28Papilledema (HP:0001085)3.73825444
29Focal seizures (HP:0007359)3.68986660
30IgM deficiency (HP:0002850)3.53162048
31Encephalitis (HP:0002383)3.52757302
32Abnormality of cells of the lymphoid lineage (HP:0012140)3.51098865
33Cellulitis (HP:0100658)3.49795877
34Urticaria (HP:0001025)3.49413627
35Petechiae (HP:0000967)3.47159804
36Agammaglobulinemia (HP:0004432)3.43913980
37Dysmetric saccades (HP:0000641)3.41765638
38Spontaneous hematomas (HP:0007420)3.40294943
39Annular pancreas (HP:0001734)3.39388067
40Chronic mucocutaneous candidiasis (HP:0002728)3.34391732
41Recurrent cutaneous fungal infections (HP:0011370)3.34391732
42B lymphocytopenia (HP:0010976)3.29344101
43Abnormality of B cell number (HP:0010975)3.29344101
44Recurrent bronchitis (HP:0002837)3.28528669
45Chest pain (HP:0100749)3.27923713
46Panhypogammaglobulinemia (HP:0003139)3.25733626
47Prolonged bleeding time (HP:0003010)3.20967704
48Inflammation of the large intestine (HP:0002037)3.17546746
49Abnormality of T cell physiology (HP:0011840)3.15924525
50Abnormality of the lower motor neuron (HP:0002366)3.13506327
51Gastrointestinal inflammation (HP:0004386)3.12679846
52Thyroiditis (HP:0100646)3.09823476
53Supranuclear gaze palsy (HP:0000605)3.08543097
54Severe combined immunodeficiency (HP:0004430)3.07562568
55Amyotrophic lateral sclerosis (HP:0007354)3.06097372
56Recurrent sinusitis (HP:0011108)3.02906916
57Pulmonary infiltrates (HP:0002113)3.01174879
58Purpura (HP:0000979)2.96868950
59Gingivitis (HP:0000230)2.96761387
60Increased IgM level (HP:0003496)2.95205297
61Hyperacusis (HP:0010780)2.90535183
62Impaired smooth pursuit (HP:0007772)2.88762408
63Hypochromic anemia (HP:0001931)2.85201790
64Keratoconjunctivitis sicca (HP:0001097)2.83910415
65Truncal ataxia (HP:0002078)2.82128332
66Epileptic encephalopathy (HP:0200134)2.80721017
67Colitis (HP:0002583)2.79774807
68Epistaxis (HP:0000421)2.79085817
69Eosinophilia (HP:0001880)2.78287174
70Hemiplegia (HP:0002301)2.78214350
71Absence seizures (HP:0002121)2.77488561
72IgG deficiency (HP:0004315)2.75329178
73Pointed chin (HP:0000307)2.74369148
74Autoimmune hemolytic anemia (HP:0001890)2.73793559
75Leukocytosis (HP:0001974)2.72052758
76Combined immunodeficiency (HP:0005387)2.71781594
77Recurrent viral infections (HP:0004429)2.66995912
78Hypochromic microcytic anemia (HP:0004840)2.66712808
79Depression (HP:0000716)2.66690990
80Atonic seizures (HP:0010819)2.65670316
81Gingival bleeding (HP:0000225)2.63472562
82Keratoconjunctivitis (HP:0001096)2.63076414
83Obstructive sleep apnea (HP:0002870)2.58327306
84Sepsis (HP:0100806)2.56823574
85Osteomyelitis (HP:0002754)2.55838096
86Poor eye contact (HP:0000817)2.55648490
87Ankyloglossia (HP:0010296)2.53683016
88Insomnia (HP:0100785)2.53196933
89Urinary urgency (HP:0000012)2.52207318
90Broad-based gait (HP:0002136)2.50195643
91Macroorchidism (HP:0000053)2.49293940
92Chronic diarrhea (HP:0002028)2.48899135
93Hypergammaglobulinemia (HP:0010702)2.47550095
94Volvulus (HP:0002580)2.45828442
95Hemoptysis (HP:0002105)2.45043616
96Hypoplasia of the thymus (HP:0000778)2.44408823
97Abnormal social behavior (HP:0012433)2.44399541
98Impaired social interactions (HP:0000735)2.44399541
99Episodic fever (HP:0001954)2.40879684
100Hyperventilation (HP:0002883)2.39281922
101Hypercortisolism (HP:0001578)2.38328890
102Emphysema (HP:0002097)2.38022911
103Impaired vibration sensation in the lower limbs (HP:0002166)2.37750192
104Stereotypic behavior (HP:0000733)2.36348484
105Restrictive lung disease (HP:0002091)2.36199909
106Abnormality of T cells (HP:0002843)2.35052721
107Ankle clonus (HP:0011448)2.34901309
108Abnormality of the corticospinal tract (HP:0002492)2.32385952
109Recurrent pneumonia (HP:0006532)2.31860220
110Dialeptic seizures (HP:0011146)2.31736380
111Urinary bladder sphincter dysfunction (HP:0002839)2.30945259
112Abnormality of binocular vision (HP:0011514)2.29296675
113Diplopia (HP:0000651)2.29296675
114Arterial thrombosis (HP:0004420)2.29224382
115Cerebral inclusion bodies (HP:0100314)2.28533242
116Verrucae (HP:0200043)2.26198799
117Papilloma (HP:0012740)2.26198799
118Premature loss of primary teeth (HP:0006323)2.25847829
119Pulmonary embolism (HP:0002204)2.25832046
120Abnormality of ocular smooth pursuit (HP:0000617)2.24310176
121Slow saccadic eye movements (HP:0000514)2.22720514
122Skin ulcer (HP:0200042)2.22613487
123Action tremor (HP:0002345)2.22209842
124Recurrent fungal infections (HP:0002841)2.22181691
125Acute hepatic failure (HP:0006554)2.18791116
126Spastic gait (HP:0002064)2.18166279
127Abnormality of oral frenula (HP:0000190)2.17959526
128Abnormal platelet volume (HP:0011876)2.15500993
129Chronic otitis media (HP:0000389)2.15052330
130Abnormality of the pleura (HP:0002103)2.14860537
131Abnormal delayed hypersensitivity skin test (HP:0002963)2.14838142
132Arthralgia (HP:0002829)2.14435535
133Recurrent lower respiratory tract infections (HP:0002783)2.14401772
134Skin rash (HP:0000988)2.12190457
135Granulocytopenia (HP:0001913)2.11481769
136Joint swelling (HP:0001386)2.10866130
137Abnormality of eosinophils (HP:0001879)2.08215630
138Anxiety (HP:0000739)2.08148314
139Apathy (HP:0000741)2.05722648
140Microcytic anemia (HP:0001935)2.03497651
141Anorexia (HP:0002039)2.02419412
142Lymphoma (HP:0002665)2.01325759
143Febrile seizures (HP:0002373)2.01232184
144Pseudobulbar signs (HP:0002200)1.99711514
145Mutism (HP:0002300)1.98691172
146Abnormality of the fingertips (HP:0001211)1.96753293
147Nasal polyposis (HP:0100582)1.96696403
148Basal cell carcinoma (HP:0002671)1.95783863
149Termporal pattern (HP:0011008)1.94496781
150Insidious onset (HP:0003587)1.94496781
151IgA deficiency (HP:0002720)1.94039390
152Amyloidosis (HP:0011034)1.94034696
153Gaze-evoked nystagmus (HP:0000640)1.91746039
154Viral hepatitis (HP:0006562)1.91720076
155Generalized tonic-clonic seizures (HP:0002069)1.91041203
156Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.89059835
157Deep palmar crease (HP:0006191)1.87472914
158Dysmetria (HP:0001310)1.85374052
159Hypoproteinemia (HP:0003075)1.84670127
160Torticollis (HP:0000473)1.84190931
161Progressive cerebellar ataxia (HP:0002073)1.83047668
162Diminished motivation (HP:0000745)1.80743762
163Menstrual irregularities (HP:0000858)1.80088127
164Inappropriate behavior (HP:0000719)1.79927752
165Drooling (HP:0002307)1.79030570
166Excessive salivation (HP:0003781)1.79030570
167Large eyes (HP:0001090)1.78951250
168Focal dystonia (HP:0004373)1.78806473
169Elfin facies (HP:0004428)1.78263616
170Acute lymphatic leukemia (HP:0006721)1.78256698
171Obsessive-compulsive behavior (HP:0000722)1.76952555
172Dysdiadochokinesis (HP:0002075)1.75976548
173Postural instability (HP:0002172)1.74902067
174Genetic anticipation (HP:0003743)1.74550571
175Sacral dimple (HP:0000960)1.73895310
176Lower limb asymmetry (HP:0100559)1.73256834
177Increased nuchal translucency (HP:0010880)1.72853478
178Open mouth (HP:0000194)1.72597335
179Megalencephaly (HP:0001355)1.71773220
180Abnormal eating behavior (HP:0100738)1.69789913
181Thickened helices (HP:0000391)1.68442571
182Neurofibrillary tangles (HP:0002185)1.68175863
183Abnormality of the periventricular white matter (HP:0002518)1.67589572

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.19219578
2BLK3.33303291
3MAP3K103.08318977
4MARK12.85186850
5MAP3K92.84399591
6IRAK42.67204497
7TRIB32.64680873
8EPHA42.56374434
9TYK22.52289004
10ERN12.33340042
11GRK62.28857676
12NTRK32.25735070
13ICK2.17749745
14BTK2.16352082
15PKN22.14325834
16IKBKE2.03125745
17JAK31.98777832
18UHMK11.95568069
19SIK31.95221406
20NTRK21.94974113
21MINK11.93613628
22MAP4K11.92093292
23SIK21.92081352
24DAPK11.85982070
25FES1.83890012
26MAP3K141.78591876
27PASK1.76063139
28PAK61.73571275
29TYRO31.73032155
30TBK11.70274554
31MAP3K71.68785738
32SMG11.63017707
33TAOK31.62441954
34CDK191.58208675
35MAP2K31.56184999
36CAMKK11.54605639
37EPHB11.53311023
38LYN1.53006862
39ITK1.52917477
40SCYL21.50193804
41ALK1.49671835
42PRKCH1.48192344
43DAPK21.46448204
44KSR21.46398251
45RIPK41.42256120
46JAK11.41904183
47MAP3K41.39939399
48CSF1R1.35321896
49TNK21.32024101
50PRPF4B1.31449431
51JAK21.26091068
52CDK51.23034102
53MARK31.22571484
54TAOK11.21898291
55KSR11.17199151
56SYK1.12331059
57HIPK21.10628918
58TEC1.09438537
59PRKD31.07103109
60MARK21.04913858
61IKBKB1.02932351
62RAF10.99173133
63CDK150.95105528
64MAPK70.94698190
65CDK180.93563305
66FGFR40.92647744
67FGR0.92594534
68PIM10.91688012
69MAP3K30.89147658
70CDK11A0.88320125
71MAPK130.87103087
72KIT0.86930832
73PDGFRB0.85595355
74CDC70.85264425
75LRRK20.85061286
76CSK0.84536598
77TLK10.83226549
78PDK10.81853183
79MAP3K130.81606336
80CDK140.79630872
81CLK10.78127825
82ZAP700.78031979
83RPS6KB20.76813535
84RET0.72094252
85BMX0.69981292
86SGK30.68453866
87MAP3K60.68437781
88ILK0.67420908
89NTRK10.66884585
90SIK10.66133410
91NLK0.65683899
92MAPK40.64647224
93MAP3K110.64177804
94PTK60.62191964
95DMPK0.60075704
96NEK10.58680843
97MAPK120.58512037
98MAP2K70.58230890
99CAMK10.56485149
100FGFR30.56032112
101CDK120.55801730
102MAPK110.55506151
103TXK0.54905053
104TAOK20.54553092
105PRKCG0.54461947
106BRSK10.54307900
107PDGFRA0.54225303
108MAP3K20.53576419
109FYN0.53269587
110STK110.53244041
111MAP3K120.52631558
112STK100.51217787
113HCK0.50473828
114TESK20.50296175
115NEK20.48424828
116TGFBR20.47722026
117FGFR20.47089239
118CDK60.46951964
119PDPK10.46882011
120CSNK1G20.45708357
121CAMKK20.45315630
122MOS0.45273937
123PRKD20.43093040
124PTK2B0.42880465
125EPHA30.42617273
126BMPR20.42268189
127MAP2K40.42198919
128MAP3K10.41165662
129MAPKAPK20.40766800
130LCK0.40226394
131PRKCQ0.39470030
132PHKG20.39449342
133PHKG10.39449342
134SGK10.39322863
135PLK20.39223281
136MAPK90.38052175
137TNIK0.37803053
138DYRK1B0.37701523
139YES10.37320340
140RPS6KL10.36846542
141RPS6KC10.36846542
142MAPK80.36201503
143CDK40.35850280
144DAPK30.34941505
145IRAK10.34672673
146GRK70.34033386
147MAP3K80.33473118
148KDR0.32518322
149CDC42BPA0.32083964
150RPS6KA60.30754756
151VRK10.29956844
152STK40.28239194
153STK380.28154989
154IRAK20.27991549
155RPS6KA50.27183683

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.34717670
2Autoimmune thyroid disease_Homo sapiens_hsa053203.20361349
3Graft-versus-host disease_Homo sapiens_hsa053323.16384482
4Leishmaniasis_Homo sapiens_hsa051402.71547601
5Long-term potentiation_Homo sapiens_hsa047202.53800026
6Type I diabetes mellitus_Homo sapiens_hsa049402.47176016
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.42993843
8Staphylococcus aureus infection_Homo sapiens_hsa051502.28592032
9Olfactory transduction_Homo sapiens_hsa047402.18962796
10Nicotine addiction_Homo sapiens_hsa050332.12604850
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.10835527
12Antigen processing and presentation_Homo sapiens_hsa046122.05833182
13Synaptic vesicle cycle_Homo sapiens_hsa047212.05068410
14Systemic lupus erythematosus_Homo sapiens_hsa053222.02405066
15Primary immunodeficiency_Homo sapiens_hsa053401.97855178
16Hematopoietic cell lineage_Homo sapiens_hsa046401.95658553
17Glutamatergic synapse_Homo sapiens_hsa047241.93367066
18Amphetamine addiction_Homo sapiens_hsa050311.92785412
19Circadian entrainment_Homo sapiens_hsa047131.91498885
20Morphine addiction_Homo sapiens_hsa050321.90084569
21Measles_Homo sapiens_hsa051621.89375422
22T cell receptor signaling pathway_Homo sapiens_hsa046601.89279519
23GABAergic synapse_Homo sapiens_hsa047271.87654689
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.85438344
25Dopaminergic synapse_Homo sapiens_hsa047281.84040209
26Asthma_Homo sapiens_hsa053101.82059536
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.81757695
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.78860177
29Gastric acid secretion_Homo sapiens_hsa049711.78517625
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.74690537
31Tuberculosis_Homo sapiens_hsa051521.70088799
32Glioma_Homo sapiens_hsa052141.65923896
33Salivary secretion_Homo sapiens_hsa049701.65914055
34Cholinergic synapse_Homo sapiens_hsa047251.65083859
35Estrogen signaling pathway_Homo sapiens_hsa049151.57257919
36Herpes simplex infection_Homo sapiens_hsa051681.56960639
37Dorso-ventral axis formation_Homo sapiens_hsa043201.56801066
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54537367
39Oxytocin signaling pathway_Homo sapiens_hsa049211.50359298
40ErbB signaling pathway_Homo sapiens_hsa040121.49045493
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47820394
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46370083
43Colorectal cancer_Homo sapiens_hsa052101.45948164
44Toxoplasmosis_Homo sapiens_hsa051451.44450002
45Influenza A_Homo sapiens_hsa051641.41203853
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40505987
47Non-small cell lung cancer_Homo sapiens_hsa052231.36977072
48Renin secretion_Homo sapiens_hsa049241.34992477
49Gap junction_Homo sapiens_hsa045401.34188019
50Endometrial cancer_Homo sapiens_hsa052131.33864453
51Long-term depression_Homo sapiens_hsa047301.31824054
52Chronic myeloid leukemia_Homo sapiens_hsa052201.31261871
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30617866
54VEGF signaling pathway_Homo sapiens_hsa043701.29743103
55Jak-STAT signaling pathway_Homo sapiens_hsa046301.29631242
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.28934399
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.27955476
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.27531532
59Malaria_Homo sapiens_hsa051441.27417700
60Viral carcinogenesis_Homo sapiens_hsa052031.23598537
61GnRH signaling pathway_Homo sapiens_hsa049121.22074482
62mTOR signaling pathway_Homo sapiens_hsa041501.19999153
63Oocyte meiosis_Homo sapiens_hsa041141.19890252
64Leukocyte transendothelial migration_Homo sapiens_hsa046701.19114945
65Cocaine addiction_Homo sapiens_hsa050301.17784042
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16863335
67Insulin secretion_Homo sapiens_hsa049111.16145785
68NOD-like receptor signaling pathway_Homo sapiens_hsa046211.16046646
69Neurotrophin signaling pathway_Homo sapiens_hsa047221.09809109
70Acute myeloid leukemia_Homo sapiens_hsa052211.09217886
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08678856
72B cell receptor signaling pathway_Homo sapiens_hsa046621.06953488
73Taste transduction_Homo sapiens_hsa047421.05786533
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05748497
75Chemokine signaling pathway_Homo sapiens_hsa040621.03481520
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01068060
77TNF signaling pathway_Homo sapiens_hsa046681.00928500
78Phagosome_Homo sapiens_hsa041451.00854999
79cAMP signaling pathway_Homo sapiens_hsa040241.00249581
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97335308
81Melanogenesis_Homo sapiens_hsa049160.97272521
82Epstein-Barr virus infection_Homo sapiens_hsa051690.96113482
83Other glycan degradation_Homo sapiens_hsa005110.95692859
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95285821
85Calcium signaling pathway_Homo sapiens_hsa040200.94126893
86Type II diabetes mellitus_Homo sapiens_hsa049300.93879006
87Axon guidance_Homo sapiens_hsa043600.93821001
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93029593
89Hepatitis C_Homo sapiens_hsa051600.92817769
90Apoptosis_Homo sapiens_hsa042100.92074107
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90778224
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.90761887
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90017699
94Notch signaling pathway_Homo sapiens_hsa043300.88623370
95MAPK signaling pathway_Homo sapiens_hsa040100.88585618
96Serotonergic synapse_Homo sapiens_hsa047260.88134584
97Choline metabolism in cancer_Homo sapiens_hsa052310.88030193
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87568380
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87533401
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86656558
101Non-homologous end-joining_Homo sapiens_hsa034500.84853631
102Rheumatoid arthritis_Homo sapiens_hsa053230.84386575
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82208480
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81524713
105Pancreatic cancer_Homo sapiens_hsa052120.80642894
106Renal cell carcinoma_Homo sapiens_hsa052110.79510263
107African trypanosomiasis_Homo sapiens_hsa051430.78362622
108Legionellosis_Homo sapiens_hsa051340.78146763
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73405143
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72791643
111Rap1 signaling pathway_Homo sapiens_hsa040150.71506545
112Endocytosis_Homo sapiens_hsa041440.70060093
113mRNA surveillance pathway_Homo sapiens_hsa030150.69964323
114Prolactin signaling pathway_Homo sapiens_hsa049170.67272853
115Insulin signaling pathway_Homo sapiens_hsa049100.66574364
116Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66221441
117Platelet activation_Homo sapiens_hsa046110.64083185
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63186429
119FoxO signaling pathway_Homo sapiens_hsa040680.62238976
120Wnt signaling pathway_Homo sapiens_hsa043100.61515490
121Alcoholism_Homo sapiens_hsa050340.61295183
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60854572
123Ras signaling pathway_Homo sapiens_hsa040140.59859667
124Thyroid cancer_Homo sapiens_hsa052160.58289378
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.57013900
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56911355
127HTLV-I infection_Homo sapiens_hsa051660.56637226
128Hepatitis B_Homo sapiens_hsa051610.56345771
129Pertussis_Homo sapiens_hsa051330.55474348
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54876359
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54055144
132Osteoclast differentiation_Homo sapiens_hsa043800.53528125
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.52936766
134Inositol phosphate metabolism_Homo sapiens_hsa005620.51356710
135Shigellosis_Homo sapiens_hsa051310.50458471
136MicroRNAs in cancer_Homo sapiens_hsa052060.49987396
137Glucagon signaling pathway_Homo sapiens_hsa049220.49701029
138Salmonella infection_Homo sapiens_hsa051320.47178805
139Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47102171
140DNA replication_Homo sapiens_hsa030300.46941184
141Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46035232
142Cyanoamino acid metabolism_Homo sapiens_hsa004600.45223930
143Thyroid hormone synthesis_Homo sapiens_hsa049180.44047927
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.42779227
145Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42765469
146Prion diseases_Homo sapiens_hsa050200.42701441
147Viral myocarditis_Homo sapiens_hsa054160.41677729
148Glycerophospholipid metabolism_Homo sapiens_hsa005640.40193062
149Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39362372
150HIF-1 signaling pathway_Homo sapiens_hsa040660.36340161
151Prostate cancer_Homo sapiens_hsa052150.29677498
152Lysosome_Homo sapiens_hsa041420.29008830
153Insulin resistance_Homo sapiens_hsa049310.27002337
154Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26195714
155SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24787885
156Regulation of autophagy_Homo sapiens_hsa041400.23979763

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