GPR179

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the glutamate receptor subfamily of G protein-coupled receptors. The encoded protein has an EGF-like calcium binding domain and a seven transmembrane domain in the N-terminal region of the protein. Mutations in this gene are associated with congenital stationary night blindness type 1E. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of light stimulus involved in sensory perception (GO:0050962)9.73634384
2detection of light stimulus involved in visual perception (GO:0050908)9.73634384
3cellular response to ATP (GO:0071318)9.19131946
4regulation of skeletal muscle contraction (GO:0014819)8.01966980
5adenosine receptor signaling pathway (GO:0001973)7.65976127
6retinal cone cell development (GO:0046549)7.43289129
7negative regulation of cell aging (GO:0090344)7.33475605
8DNA strand renaturation (GO:0000733)7.18477883
9photoreceptor cell development (GO:0042461)7.10123567
10eye photoreceptor cell development (GO:0042462)7.05092888
11rhodopsin mediated signaling pathway (GO:0016056)6.98056689
12meiotic chromosome segregation (GO:0045132)6.94898126
13GDP-mannose metabolic process (GO:0019673)6.91055449
14regulation of synapse structural plasticity (GO:0051823)6.88849829
15cellular potassium ion homeostasis (GO:0030007)6.68267958
16regulation of rhodopsin mediated signaling pathway (GO:0022400)6.57049889
17negative regulation of cytosolic calcium ion concentration (GO:0051481)6.42732000
18photoreceptor cell maintenance (GO:0045494)6.28211158
19purinergic nucleotide receptor signaling pathway (GO:0035590)6.12491278
20G-protein coupled glutamate receptor signaling pathway (GO:0007216)6.07030749
21response to pheromone (GO:0019236)5.85575359
22potassium ion homeostasis (GO:0055075)5.83461445
23regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.82626694
24G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.77762873
25adenine nucleotide transport (GO:0051503)5.59502088
26peristalsis (GO:0030432)5.55058016
27positive regulation of protein kinase C signaling (GO:0090037)5.48356938
28lens fiber cell differentiation (GO:0070306)5.47591019
29positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.47272718
30sensory perception of taste (GO:0050909)5.40962170
31peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)5.24405161
32rRNA methylation (GO:0031167)5.22508413
33sodium ion export (GO:0071436)5.21778711
34innervation (GO:0060384)5.08980607
35purine ribonucleotide transport (GO:0015868)5.06623387
36response to ATP (GO:0033198)4.99366759
37regulation of short-term neuronal synaptic plasticity (GO:0048172)4.98423609
38regulation of bile acid biosynthetic process (GO:0070857)4.97124458
39behavioral response to nicotine (GO:0035095)4.96360234
40positive regulation of synapse maturation (GO:0090129)4.95611061
41neuromuscular synaptic transmission (GO:0007274)4.85197778
42detection of visible light (GO:0009584)4.82826850
43protein-chromophore linkage (GO:0018298)4.77757009
44purinergic receptor signaling pathway (GO:0035587)4.68226883
45detection of light stimulus (GO:0009583)4.66629626
46* sensory perception of light stimulus (GO:0050953)4.60919923
47* visual perception (GO:0007601)4.58958140
48protein localization to synapse (GO:0035418)4.58801861
49positive regulation of catecholamine secretion (GO:0033605)4.58194783
50nucleoside transmembrane transport (GO:1901642)4.51387030
51regulation of protein kinase A signaling (GO:0010738)4.47969030
52rRNA modification (GO:0000154)4.47775508
53synaptic vesicle maturation (GO:0016188)4.42028375
54purine nucleotide transport (GO:0015865)4.41938161
55melanin biosynthetic process (GO:0042438)4.40668343
56peptidyl-glutamic acid carboxylation (GO:0017187)4.37643439
57protein carboxylation (GO:0018214)4.37643439
58positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.35302531
59synaptic vesicle exocytosis (GO:0016079)4.33515145
60mitotic cell cycle arrest (GO:0071850)4.30195032
61striatum development (GO:0021756)4.15929945
62phototransduction, visible light (GO:0007603)4.14470238
63nucleotide transmembrane transport (GO:1901679)4.13156146
64nonmotile primary cilium assembly (GO:0035058)4.09739700
65phototransduction (GO:0007602)4.08227089
66synaptic vesicle endocytosis (GO:0048488)4.07506915
67regulation of cytokine production involved in inflammatory response (GO:1900015)4.06302733
68synaptic vesicle docking involved in exocytosis (GO:0016081)4.05768019
69embryonic retina morphogenesis in camera-type eye (GO:0060059)3.99767367
70activation of adenylate cyclase activity (GO:0007190)3.91282678
71cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.90406696
72melanin metabolic process (GO:0006582)3.89901491
73regulation of synaptic vesicle exocytosis (GO:2000300)3.88937621
74regulation of synapse maturation (GO:0090128)3.85133263
75membrane hyperpolarization (GO:0060081)3.83982270
76GMP metabolic process (GO:0046037)3.83448169
77sex determination (GO:0007530)3.82981029
78retina development in camera-type eye (GO:0060041)3.78584436
79urinary tract smooth muscle contraction (GO:0014848)3.77454623
80potassium ion export (GO:0071435)3.75037925
81G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.74389433
82cellular response to light stimulus (GO:0071482)3.74093933
83relaxation of smooth muscle (GO:0044557)3.70981167
84transepithelial transport (GO:0070633)3.67064109
85purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.62106839
863-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.62106839
87mating behavior (GO:0007617)3.59625133
88phosphate ion transmembrane transport (GO:0035435)3.55686672
89gamma-aminobutyric acid signaling pathway (GO:0007214)3.54771952
90regulation of phospholipid biosynthetic process (GO:0071071)3.54363557
91secondary metabolite biosynthetic process (GO:0044550)3.53996907
92positive regulation of adenylate cyclase activity (GO:0045762)3.52060843
93response to gravity (GO:0009629)3.49228395
94detection of external stimulus (GO:0009581)3.47174807
95detection of abiotic stimulus (GO:0009582)3.44637780
96sialylation (GO:0097503)3.43928753
97UV protection (GO:0009650)3.42681956
98righting reflex (GO:0060013)3.39164273
99positive regulation of gastrulation (GO:2000543)3.38906119
100positive regulation of cyclase activity (GO:0031281)3.37541123
101gonadal mesoderm development (GO:0007506)3.32907592
102cell communication by electrical coupling (GO:0010644)3.32075726
103photoreceptor cell differentiation (GO:0046530)3.28825892
104eye photoreceptor cell differentiation (GO:0001754)3.28825892
105grooming behavior (GO:0007625)3.26069912
106calcium ion import (GO:0070509)3.24596886
107phosphate ion transport (GO:0006817)3.24439597
108response to histamine (GO:0034776)3.24274619
109nucleotide-sugar biosynthetic process (GO:0009226)3.23483378
110cellular sodium ion homeostasis (GO:0006883)3.23446901
111apical protein localization (GO:0045176)3.23345625
112negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.22943270
113ionotropic glutamate receptor signaling pathway (GO:0035235)3.21934517
114somite rostral/caudal axis specification (GO:0032525)3.20483799
115histone phosphorylation (GO:0016572)3.19721489
116positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.19300503
117behavioral response to ethanol (GO:0048149)3.17793246
118mitochondrion distribution (GO:0048311)3.17729340
119positive regulation of lyase activity (GO:0051349)3.16793845
120positive regulation of dendritic spine morphogenesis (GO:0061003)3.15125591
121purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.15078758
122ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.15078758
123nucleoside bisphosphate biosynthetic process (GO:0033866)3.15078758
124glutamate secretion (GO:0014047)3.13921844
125potassium ion import (GO:0010107)3.13390486
126desmosome organization (GO:0002934)3.12396421
127regulation of synaptic vesicle transport (GO:1902803)3.12237403
128behavioral response to pain (GO:0048266)3.11340298
129regulation of cell aging (GO:0090342)3.08289417
130cilium or flagellum-dependent cell motility (GO:0001539)3.03653141
131negative regulation of interleukin-8 production (GO:0032717)3.02236836
132phasic smooth muscle contraction (GO:0014821)3.01221499
133membrane repolarization (GO:0086009)3.00294666
134nucleoside transport (GO:0015858)2.97741157
135positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.97586059
136cerebellar Purkinje cell differentiation (GO:0021702)2.97306472
137regulation of voltage-gated calcium channel activity (GO:1901385)2.96638824
138regulation of clathrin-mediated endocytosis (GO:2000369)2.95413998
139positive regulation of heat generation (GO:0031652)2.95142199
140trivalent inorganic anion homeostasis (GO:0072506)2.93449722
141phosphate ion homeostasis (GO:0055062)2.93449722
142postsynaptic membrane organization (GO:0001941)2.93208231
143regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.91947732
144regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.91947732
145positive regulation of cell cycle checkpoint (GO:1901978)2.90499069
146protein import into peroxisome matrix (GO:0016558)2.88217067
147sphingomyelin metabolic process (GO:0006684)2.87741123
148positive regulation of cAMP biosynthetic process (GO:0030819)2.87025484
149synaptic transmission, cholinergic (GO:0007271)2.85093608
150positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.84260486
151synapse assembly (GO:0007416)2.83332041
152neurotransmitter-gated ion channel clustering (GO:0072578)2.83015531
153atrial cardiac muscle cell action potential (GO:0086014)2.82986271
154cellular anion homeostasis (GO:0030002)2.82528753
155substrate-independent telencephalic tangential migration (GO:0021826)2.82059916
156substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.82059916
157estrogen biosynthetic process (GO:0006703)2.81099912
158establishment of synaptic vesicle localization (GO:0097480)2.81048907
159synaptic vesicle transport (GO:0048489)2.81048907
160long-term synaptic potentiation (GO:0060291)2.80766101
161neurotransmitter transport (GO:0006836)2.80625456
162primitive streak formation (GO:0090009)2.80581586
163regulation of protein kinase C signaling (GO:0090036)2.79973953
164regulation of respiratory gaseous exchange (GO:0043576)2.79223601
165muscle fiber development (GO:0048747)2.79048212
166cell migration in hindbrain (GO:0021535)2.78801545
167regulation of sarcomere organization (GO:0060297)2.76695182
168sulfur amino acid catabolic process (GO:0000098)2.75923840
169neuron cell-cell adhesion (GO:0007158)2.75730573
170dentate gyrus development (GO:0021542)2.75638181
171glutamate receptor signaling pathway (GO:0007215)2.74222273
172lactate metabolic process (GO:0006089)2.74033341
173neurotransmitter secretion (GO:0007269)2.73706547
174long term synaptic depression (GO:0060292)2.73141348
175sensory perception of chemical stimulus (GO:0007606)2.73039229
176vocalization behavior (GO:0071625)2.71013806
177regulation of nuclear cell cycle DNA replication (GO:0033262)2.70345893
178prepulse inhibition (GO:0060134)2.69526650
179glycine transport (GO:0015816)2.69098064
180cardiolipin metabolic process (GO:0032048)2.68893562
181potassium ion transmembrane transport (GO:0071805)2.68593343
182cellular potassium ion transport (GO:0071804)2.68593343
183synaptic transmission, glutamatergic (GO:0035249)2.68129128
184cerebellar granule cell differentiation (GO:0021707)2.67781148
185neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.67616144
186iron coordination entity transport (GO:1901678)2.65466519
187sphingosine metabolic process (GO:0006670)2.65135754
188regulation of guanylate cyclase activity (GO:0031282)2.64956199
189renal absorption (GO:0070293)2.63660608
190regulation of excitatory postsynaptic membrane potential (GO:0060079)2.63265968
191positive regulation of cyclic nucleotide biosynthetic process (GO:0030804)2.62220249
192retinal rod cell development (GO:0046548)11.0110716

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human4.29261919
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.05621947
3GBX2_23144817_ChIP-Seq_PC3_Human3.96798586
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.50956835
5P68_20966046_ChIP-Seq_HELA_Human3.30383296
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.23099972
7CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human3.11291341
8LXR_22292898_ChIP-Seq_THP-1_Human2.95696274
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.88240037
10TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.70350983
11DROSHA_22980978_ChIP-Seq_HELA_Human2.61323911
12ERG_21242973_ChIP-ChIP_JURKAT_Human2.59407493
13REST_21632747_ChIP-Seq_MESCs_Mouse2.50877674
14E2F1_20622854_ChIP-Seq_HELA_Human2.45553248
15BCL6_27268052_Chip-Seq_Bcells_Human2.42731954
16P53_22127205_ChIP-Seq_FIBROBLAST_Human2.40911580
17MAF_26560356_Chip-Seq_TH2_Human2.39243237
18MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human2.37249328
19BCOR_27268052_Chip-Seq_Bcells_Human2.35373118
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.34119869
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32773365
22PHF8_20622854_ChIP-Seq_HELA_Human2.22688420
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.18573512
24SMC4_20622854_ChIP-Seq_HELA_Human2.17943406
25* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.15642262
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14302192
27JARID2_20075857_ChIP-Seq_MESCs_Mouse2.10327435
28SMAD2/3_21741376_ChIP-Seq_ESCs_Human2.09736620
29RARG_19884340_ChIP-ChIP_MEFs_Mouse2.06504120
30CTCF_27219007_Chip-Seq_ERYTHROID_Human2.03891514
31SUZ12_27294783_Chip-Seq_ESCs_Mouse2.02097366
32EZH2_27304074_Chip-Seq_ESCs_Mouse2.01721961
33TET1_21451524_ChIP-Seq_MESCs_Mouse2.01523811
34IGF1R_20145208_ChIP-Seq_DFB_Human1.99992964
35AR_21572438_ChIP-Seq_LNCaP_Human1.99037143
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.96884336
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.96501794
38* RARB_24833708_ChIP-Seq_LIVER_Mouse1.96403092
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.94519547
40XRN2_22483619_ChIP-Seq_HELA_Human1.94158360
41VDR_24763502_ChIP-Seq_THP-1_Human1.94064516
42* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92507967
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92392589
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92087194
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92087194
46RXRA_24833708_ChIP-Seq_LIVER_Mouse1.89831338
47REST_18959480_ChIP-ChIP_MESCs_Mouse1.89813932
48CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.89743976
49RARA_24833708_ChIP-Seq_LIVER_Mouse1.89734807
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.88064443
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85348895
52RARB_27405468_Chip-Seq_BRAIN_Mouse1.84703425
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82944658
54SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.82523167
55DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.82130980
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81451425
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.80596710
58SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.79499817
59RACK7_27058665_Chip-Seq_MCF-7_Human1.79069586
60CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.78179475
61SMAD4_21799915_ChIP-Seq_A2780_Human1.77059102
62KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76556750
63CTCF_20526341_ChIP-Seq_ESCs_Human1.75432040
64ELF1_20517297_ChIP-Seq_JURKAT_Human1.73743098
65FOXP1_21924763_ChIP-Seq_HESCs_Human1.73728283
66ERA_21632823_ChIP-Seq_H3396_Human1.70972687
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70738235
68SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.69344724
69EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.69098090
70GATA1_22025678_ChIP-Seq_K562_Human1.68451114
71MAF_26560356_Chip-Seq_TH1_Human1.64908563
72* SA1_27219007_Chip-Seq_ERYTHROID_Human1.63146206
73CTCF_21964334_Chip-Seq_Bcells_Human1.63067471
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.60380453
75SMAD3_21741376_ChIP-Seq_HESCs_Human1.59933397
76DNAJC2_21179169_ChIP-ChIP_NT2_Human1.58178601
77NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.57587783
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55872245
79CREB1_26743006_Chip-Seq_LNCaP_Human1.53864166
80SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52467069
81AR_19668381_ChIP-Seq_PC3_Human1.52102962
82SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.51367588
83SA1_27219007_Chip-Seq_Bcells_Human1.50628491
84EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.50439142
85CTCF_21964334_ChIP-Seq_BJAB-B_Human1.50212043
86RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.50167475
87EED_16625203_ChIP-ChIP_MESCs_Mouse1.50094125
88RNF2_27304074_Chip-Seq_NSC_Mouse1.49383775
89DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.49115411
90STAT3_23295773_ChIP-Seq_U87_Human1.48818234
91E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48096446
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.47656799
93KDM2B_26808549_Chip-Seq_DND41_Human1.46052786
94IKZF1_21737484_ChIP-ChIP_HCT116_Human1.45054563
95KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43557694
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.43157246
97ESR2_21235772_ChIP-Seq_MCF-7_Human1.43112466
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41763192
99YY1_22570637_ChIP-Seq_MALME-3M_Human1.40770931
100TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.40498087
101OCT4_19829295_ChIP-Seq_ESCs_Human1.39793528
102TP53_22127205_ChIP-Seq_IMR90_Human1.35472751
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34698158
104UTX_26944678_Chip-Seq_JUKART_Human1.33338094
105RING1B_27294783_Chip-Seq_NPCs_Mouse1.33319446
106FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.31333356
107YAP1_20516196_ChIP-Seq_MESCs_Mouse1.30758028
108P53_21459846_ChIP-Seq_SAOS-2_Human1.29979332
109ETS1_21867929_ChIP-Seq_TH2_Mouse1.28693921
110RING1B_27294783_Chip-Seq_ESCs_Mouse1.28515560
111OCT4_20526341_ChIP-Seq_ESCs_Human1.27081913
112TP63_22573176_ChIP-Seq_HFKS_Human1.26580827
113SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.26305178
114SOX2_21211035_ChIP-Seq_LN229_Gbm1.24955643
115CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24595487
116RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24347566
117FUS_26573619_Chip-Seq_HEK293_Human1.23632410
118CBX2_27304074_Chip-Seq_ESCs_Mouse1.23376594
119TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21143150
120JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.21004041
121TCF4_23295773_ChIP-Seq_U87_Human1.20898360
122* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20523225
123TAF2_19829295_ChIP-Seq_ESCs_Human1.18643885
124ELK4_26923725_Chip-Seq_MESODERM_Mouse1.16939926
125SMAD4_21741376_ChIP-Seq_HESCs_Human1.16398662
126TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16067475
127WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15903841
128ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15728175
129DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15574667
130P300_27268052_Chip-Seq_Bcells_Human1.15473760
131SMC3_22415368_ChIP-Seq_MEFs_Mouse1.15166801
132SMAD3_21741376_ChIP-Seq_EPCs_Human1.15043862
133MYC_19829295_ChIP-Seq_ESCs_Human1.14791718
134TBX3_20139965_ChIP-Seq_MESCs_Mouse1.12415891
135POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12309740
136TP53_23651856_ChIP-Seq_MEFs_Mouse1.12239204
137GATA3_21867929_ChIP-Seq_CD8_Mouse1.11382785
138SMAD_19615063_ChIP-ChIP_OVARY_Human1.11338705
139TBX3_20139965_ChIP-Seq_ESCs_Mouse1.10769332
140P300_19829295_ChIP-Seq_ESCs_Human1.10318838
141IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10218223
142CBP_20019798_ChIP-Seq_JUKART_Human1.10218223
143NANOG_20526341_ChIP-Seq_ESCs_Human1.09977113
144MYC_22102868_ChIP-Seq_BL_Human1.08547010
145ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08475451
146CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08320715
147AR_25329375_ChIP-Seq_VCAP_Human1.08290460
148RUNX1_27514584_Chip-Seq_MCF-7_Human1.08202894
149RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08050758
150PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08037581
151PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07751952
152UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07213152
153FLI1_21867929_ChIP-Seq_TH2_Mouse1.06672222
154LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04987352
155* TCF7_22412390_ChIP-Seq_EML_Mouse1.04337688
156PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.04258963
157* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04140639
158MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03109423
159TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02443888
160KLF4_19829295_ChIP-Seq_ESCs_Human1.01954061
161* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01040601
162KDM2B_26808549_Chip-Seq_K562_Human1.00842337
163* CTCF_27219007_Chip-Seq_Bcells_Human0.99034460
164TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98554846
165AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97911891
166ARNT_22903824_ChIP-Seq_MCF-7_Human0.97563495
167KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97025610
168RAC3_21632823_ChIP-Seq_H3396_Human0.96928027
169SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95909763
170BCAT_22108803_ChIP-Seq_LS180_Human0.95892688
171SMAD3_21741376_ChIP-Seq_ESCs_Human0.95689556
172TBL1_22424771_ChIP-Seq_293T_Human0.94898172
173OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93128878
174CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91854068
175TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91846832
176POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91740918
177TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91740918
178TP63_19390658_ChIP-ChIP_HaCaT_Human0.91547969
179TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89986936
180ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89717408
181TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89682061
182WDR5_24793694_ChIP-Seq_LNCAP_Human0.88500131
183AHR_22903824_ChIP-Seq_MCF-7_Human0.88200747
184ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87799020

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog7.53189368
2MP0005171_absent_coat_pigmentation6.65136035
3MP0003136_yellow_coat_color6.16521422
4MP0005174_abnormal_tail_pigmentation5.86602055
5MP0006072_abnormal_retinal_apoptosis5.65530439
6MP0003011_delayed_dark_adaptation5.08134686
7MP0005253_abnormal_eye_physiology4.82585355
8MP0002090_abnormal_vision4.52924168
9MP0005409_darkened_coat_color3.77054998
10MP0001984_abnormal_olfaction3.35190571
11MP0006292_abnormal_olfactory_placode3.24374630
12MP0005195_abnormal_posterior_eye3.01491913
13MP0002736_abnormal_nociception_after2.53914667
14MP0001502_abnormal_circadian_rhythm2.41641869
15MP0002735_abnormal_chemical_nociception2.40330498
16MP0001324_abnormal_eye_pigmentation2.39307389
17MP0005499_abnormal_olfactory_system2.33672264
18MP0005394_taste/olfaction_phenotype2.33672264
19MP0005391_vision/eye_phenotype2.31099277
20MP0003950_abnormal_plasma_membrane2.25756539
21MP0002229_neurodegeneration2.21202324
22MP0002653_abnormal_ependyma_morphology2.19907713
23MP0002909_abnormal_adrenal_gland2.12338437
24MP0000015_abnormal_ear_pigmentation2.11884870
25MP0004233_abnormal_muscle_weight2.08254628
26MP0005083_abnormal_biliary_tract2.04650210
27MP0010386_abnormal_urinary_bladder2.04469848
28MP0000751_myopathy2.03323610
29MP0002638_abnormal_pupillary_reflex2.01617939
30MP0001756_abnormal_urination2.00918380
31MP0004381_abnormal_hair_follicle2.00291224
32MP0005423_abnormal_somatic_nervous1.97838442
33MP0010368_abnormal_lymphatic_system1.94021745
34MP0004130_abnormal_muscle_cell1.88531940
35MP0001486_abnormal_startle_reflex1.85273956
36MP0002752_abnormal_somatic_nervous1.81476393
37MP0008789_abnormal_olfactory_epithelium1.76149727
38MP0004782_abnormal_surfactant_physiolog1.75826242
39MP0003890_abnormal_embryonic-extraembry1.70071403
40MP0008875_abnormal_xenobiotic_pharmacok1.68997853
41MP0004043_abnormal_pH_regulation1.68502193
42MP0003880_abnormal_central_pattern1.66238051
43MP0002332_abnormal_exercise_endurance1.63862034
44MP0005248_abnormal_Harderian_gland1.63565298
45MP0009046_muscle_twitch1.58474274
46MP0000538_abnormal_urinary_bladder1.53461561
47MP0005377_hearing/vestibular/ear_phenot1.45392257
48MP0003878_abnormal_ear_physiology1.45392257
49MP0001348_abnormal_lacrimal_gland1.43671479
50MP0002882_abnormal_neuron_morphology1.41217493
51MP0004270_analgesia1.39846152
52MP0003635_abnormal_synaptic_transmissio1.39390820
53MP0002064_seizures1.35583777
54MP0002272_abnormal_nervous_system1.35391665
55MP0003183_abnormal_peptide_metabolism1.34749001
56MP0010030_abnormal_orbit_morphology1.34152496
57MP0000013_abnormal_adipose_tissue1.29052565
58MP0002734_abnormal_mechanical_nocicepti1.28012405
59MP0004215_abnormal_myocardial_fiber1.24647709
60MP0001968_abnormal_touch/_nociception1.22307482
61MP0002067_abnormal_sensory_capabilities1.21902122
62MP0000750_abnormal_muscle_regeneration1.18869337
63MP0000631_abnormal_neuroendocrine_gland1.16937016
64MP0002184_abnormal_innervation1.15416679
65MP0004147_increased_porphyrin_level1.13154236
66MP0005410_abnormal_fertilization1.12152002
67MP0001346_abnormal_lacrimal_gland1.10722891
68MP0002063_abnormal_learning/memory/cond1.07627710
69MP0001188_hyperpigmentation1.06886379
70MP0002572_abnormal_emotion/affect_behav1.05445497
71MP0002234_abnormal_pharynx_morphology1.05041281
72MP0001905_abnormal_dopamine_level0.98849891
73MP0001765_abnormal_ion_homeostasis0.98800983
74MP0008961_abnormal_basal_metabolism0.97639086
75MP0008775_abnormal_heart_ventricle0.96362505
76MP0005076_abnormal_cell_differentiation0.95470160
77MP0005332_abnormal_amino_acid0.93697287
78MP0000003_abnormal_adipose_tissue0.93359847
79MP0002127_abnormal_cardiovascular_syste0.93057861
80MP0002160_abnormal_reproductive_system0.91891327
81MP0001664_abnormal_digestion0.91794461
82MP0004036_abnormal_muscle_relaxation0.90265914
83MP0004858_abnormal_nervous_system0.89998693
84MP0009745_abnormal_behavioral_response0.89581637
85MP0003172_abnormal_lysosome_physiology0.89233692
86MP0005220_abnormal_exocrine_pancreas0.88370392
87MP0003879_abnormal_hair_cell0.88273407
88MP0008569_lethality_at_weaning0.86991316
89MP0003868_abnormal_feces_composition0.86681388
90MP0005330_cardiomyopathy0.85709245
91MP0005584_abnormal_enzyme/coenzyme_acti0.84862023
92MP0003453_abnormal_keratinocyte_physiol0.84348421
93MP0005167_abnormal_blood-brain_barrier0.83078689
94MP0001661_extended_life_span0.82360078
95MP0002822_catalepsy0.81126382
96MP0005365_abnormal_bile_salt0.80151314
97MP0003122_maternal_imprinting0.79876392
98MP0004859_abnormal_synaptic_plasticity0.79391875
99MP0001986_abnormal_taste_sensitivity0.78596315
100MP0003111_abnormal_nucleus_morphology0.76326142
101MP0000747_muscle_weakness0.75279713
102MP0006276_abnormal_autonomic_nervous0.75078643
103MP0004019_abnormal_vitamin_homeostasis0.74927617
104MP0005595_abnormal_vascular_smooth0.74826433
105MP0000534_abnormal_ureter_morphology0.72913575
106MP0003123_paternal_imprinting0.72768679
107MP0004084_abnormal_cardiac_muscle0.72503116
108MP0000955_abnormal_spinal_cord0.70939868
109MP0005670_abnormal_white_adipose0.70595377
110MP0005386_behavior/neurological_phenoty0.70053427
111MP0004924_abnormal_behavior0.70053427
112MP0004145_abnormal_muscle_electrophysio0.69750734
113MP0004264_abnormal_extraembryonic_tissu0.69431031
114MP0001270_distended_abdomen0.68621674
115MP0004185_abnormal_adipocyte_glucose0.67515495
116MP0004885_abnormal_endolymph0.67449993
117MP0003634_abnormal_glial_cell0.67298279
118MP0002733_abnormal_thermal_nociception0.66723202
119MP0003632_abnormal_nervous_system0.66565811
120MP0003787_abnormal_imprinting0.66354690
121MP0004085_abnormal_heartbeat0.64595328
122MP0001963_abnormal_hearing_physiology0.64287297
123MP0002697_abnormal_eye_size0.64190282
124MP0005197_abnormal_uvea_morphology0.62034097
125MP0003045_fibrosis0.60724572
126MP0003283_abnormal_digestive_organ0.60356907
127MP0002557_abnormal_social/conspecific_i0.60277684
128MP0003137_abnormal_impulse_conducting0.60267019
129MP0001958_emphysema0.58578251
130MP0004811_abnormal_neuron_physiology0.58097949
131MP0002751_abnormal_autonomic_nervous0.57970390
132MP0003121_genomic_imprinting0.56780702
133MP0003646_muscle_fatigue0.56733036
134MP0001970_abnormal_pain_threshold0.56025249
135MP0004142_abnormal_muscle_tone0.54230300
136MP0001944_abnormal_pancreas_morphology0.54110967
137MP0002152_abnormal_brain_morphology0.54036931
138MP0005448_abnormal_energy_balance0.53369011
139MP0004742_abnormal_vestibular_system0.52966171
140MP0002069_abnormal_eating/drinking_beha0.52847830
141MP0000778_abnormal_nervous_system0.52826495
142MP0008872_abnormal_physiological_respon0.52745781
143MP0002928_abnormal_bile_duct0.52594143
144MP0005257_abnormal_intraocular_pressure0.52151594
145MP0002277_abnormal_respiratory_mucosa0.52144926
146MP0002066_abnormal_motor_capabilities/c0.50518986
147MP0008874_decreased_physiological_sensi0.50209289
148MP0000470_abnormal_stomach_morphology0.50120984
149MP0005535_abnormal_body_temperature0.45423588
150MP0000367_abnormal_coat/_hair0.43920648
151MP0003329_amyloid_beta_deposits0.42694332
152MP0002075_abnormal_coat/hair_pigmentati0.42352178
153MP0000026_abnormal_inner_ear0.41900292
154MP0005375_adipose_tissue_phenotype0.40923916
155MP0005084_abnormal_gallbladder_morpholo0.39793073
156MP0003631_nervous_system_phenotype0.39470297
157MP0010771_integument_phenotype0.38751154
158MP0009643_abnormal_urine_homeostasis0.38099923
159MP0002095_abnormal_skin_pigmentation0.36405180
160MP0005501_abnormal_skin_physiology0.34918305
161MP0001501_abnormal_sleep_pattern0.34103423
162MP0002118_abnormal_lipid_homeostasis0.33688330
163MP0000358_abnormal_cell_content/0.33414349

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macular pigmentation (HP:0008002)8.12392484
2Central scotoma (HP:0000603)8.01129519
3Abnormal rod and cone electroretinograms (HP:0008323)7.83658534
4Severe visual impairment (HP:0001141)7.70578954
5Decreased central vision (HP:0007663)7.40139254
6Bony spicule pigmentary retinopathy (HP:0007737)7.01515539
7Pendular nystagmus (HP:0012043)6.70408969
8Absent rod-and cone-mediated responses on ERG (HP:0007688)6.55972742
9Rib fusion (HP:0000902)6.27304336
10Scotoma (HP:0000575)6.25509997
11Testicular atrophy (HP:0000029)5.83210256
12Annular pancreas (HP:0001734)5.49923128
13Akinesia (HP:0002304)5.30742479
14Rectovaginal fistula (HP:0000143)5.26971984
15Rectal fistula (HP:0100590)5.26971984
16Dyschromatopsia (HP:0007641)5.18301221
17Intestinal fistula (HP:0100819)5.11239767
18Poikiloderma (HP:0001029)5.02145854
19Vaginal fistula (HP:0004320)4.84842497
20Popliteal pterygium (HP:0009756)4.70296019
21Abolished electroretinogram (ERG) (HP:0000550)4.58670956
22Attenuation of retinal blood vessels (HP:0007843)4.57579533
23Turricephaly (HP:0000262)4.55052806
24Fetal akinesia sequence (HP:0001989)4.49735562
25Facial hemangioma (HP:0000329)4.49500258
26Ulnar bowing (HP:0003031)4.37207639
27Increased corneal curvature (HP:0100692)4.33136483
28Keratoconus (HP:0000563)4.33136483
29Thin bony cortex (HP:0002753)4.30461014
30Abnormality of the intrinsic pathway (HP:0010989)4.19369427
31Facial diplegia (HP:0001349)4.14872896
32Chorioretinal atrophy (HP:0000533)4.09853390
33Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.02068306
34Coronal craniosynostosis (HP:0004440)4.02030990
35Birth length less than 3rd percentile (HP:0003561)3.92669065
36Epileptic encephalopathy (HP:0200134)3.92022895
37Aplasia of the musculature (HP:0100854)3.91872813
38Short chin (HP:0000331)3.90040027
39Febrile seizures (HP:0002373)3.86745835
40Pigmentary retinal degeneration (HP:0001146)3.82650383
41Hypoplasia of the fovea (HP:0007750)3.80039628
42Aplasia/Hypoplasia of the fovea (HP:0008060)3.80039628
43Septo-optic dysplasia (HP:0100842)3.79272264
44Patellar aplasia (HP:0006443)3.67355991
45Macular degeneration (HP:0000608)3.65549435
46Cone-rod dystrophy (HP:0000548)3.62768114
47Photophobia (HP:0000613)3.53009384
48Type II diabetes mellitus (HP:0005978)3.44532062
49Squamous cell carcinoma (HP:0002860)3.41498712
50Prolonged partial thromboplastin time (HP:0003645)3.38346774
51Aplasia/Hypoplasia of the patella (HP:0006498)3.37973757
52Anteriorly placed anus (HP:0001545)3.21147277
53Abnormality of the fovea (HP:0000493)3.19734849
54Abnormality of placental membranes (HP:0011409)3.12769787
55Amniotic constriction ring (HP:0009775)3.12769787
56Joint hemorrhage (HP:0005261)3.11928548
57Delayed epiphyseal ossification (HP:0002663)3.11169366
58Absence seizures (HP:0002121)3.05938245
59Myotonia (HP:0002486)3.03171542
60Enlarged epiphyses (HP:0010580)3.00810928
61Mesangial abnormality (HP:0001966)3.00063863
62Constricted visual fields (HP:0001133)2.97687819
63Abnormal albumin level (HP:0012116)2.97686793
64Hypoalbuminemia (HP:0003073)2.97686793
65Congenital sensorineural hearing impairment (HP:0008527)2.97423066
66Retinitis pigmentosa (HP:0000510)2.94788761
67Atrioventricular block (HP:0001678)2.87607210
68Premature graying of hair (HP:0002216)2.85109604
69Hemorrhage of the eye (HP:0011885)2.78684288
70Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.74623400
71Capillary hemangiomas (HP:0005306)2.74117144
72Abnormality of the costochondral junction (HP:0000919)2.71748436
73Posterior subcapsular cataract (HP:0007787)2.70615304
74Aplasia/Hypoplasia of the macula (HP:0008059)2.69859504
75Male infertility (HP:0003251)2.63302930
76Choanal stenosis (HP:0000452)2.59668665
77Flat occiput (HP:0005469)2.55813840
78Dialeptic seizures (HP:0011146)2.55566195
79Aplasia/Hypoplasia involving the musculature (HP:0001460)2.54374135
80Widely patent fontanelles and sutures (HP:0004492)2.52324530
81Hypophosphatemic rickets (HP:0004912)2.49531257
82Aplasia/Hypoplasia affecting the retina (HP:0008061)2.47946014
83Gait imbalance (HP:0002141)2.45051586
84Breast hypoplasia (HP:0003187)2.39416405
85Polydipsia (HP:0001959)2.37678226
86Abnormal drinking behavior (HP:0030082)2.37678226
87Progressive cerebellar ataxia (HP:0002073)2.37550039
88Congenital primary aphakia (HP:0007707)2.37264473
89Malignant hyperthermia (HP:0002047)2.37103712
90Narrow nasal bridge (HP:0000446)2.34416586
91Albinism (HP:0001022)2.33180070
92Joint stiffness (HP:0001387)2.30938031
93Diminished movement (HP:0002374)2.30449322
94Severe Myopia (HP:0011003)2.30129428
95Prolonged QT interval (HP:0001657)2.30014193
96Absent thumb (HP:0009777)2.24310798
97Bowed forearm bones (HP:0003956)2.23970590
98Bowing of the arm (HP:0006488)2.23970590
99True hermaphroditism (HP:0010459)2.18346282
100Neonatal respiratory distress (HP:0002643)2.18076429
101Abnormality of the lower motor neuron (HP:0002366)2.16294038
102Choroideremia (HP:0001139)2.14190363
103Decreased circulating renin level (HP:0003351)2.11861131
104Cystic hygroma (HP:0000476)2.11544320
105Dysdiadochokinesis (HP:0002075)2.11305488
106Reduced antithrombin III activity (HP:0001976)2.08921809
107Increased number of teeth (HP:0011069)2.08602570
108Nephrogenic diabetes insipidus (HP:0009806)2.06610633
109Heart block (HP:0012722)2.04159519
110Pancreatic fibrosis (HP:0100732)2.03403426
111Thin ribs (HP:0000883)2.02061025
112Medial flaring of the eyebrow (HP:0010747)2.02011878
113Abnormal epiphyseal ossification (HP:0010656)2.01629004
114Neonatal onset (HP:0003623)2.01119929
115* Congenital stationary night blindness (HP:0007642)14.3163127
116Myopathic facies (HP:0002058)1.99879146
117Zonular cataract (HP:0010920)1.96757424
118Progressive visual loss (HP:0000529)1.95744587
119Pterygium (HP:0001059)1.95245715
120Basal cell carcinoma (HP:0002671)1.94632241
121Hemiparesis (HP:0001269)1.93590895
122Dyskinesia (HP:0100660)1.92816418
123Renal Fanconi syndrome (HP:0001994)1.91271028
124Short humerus (HP:0005792)1.90680621
125Abnormality of the hepatic vasculature (HP:0006707)1.90680237
126Visual hallucinations (HP:0002367)1.89176799
127Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.88984335
128Absent speech (HP:0001344)1.88982714
129Horizontal nystagmus (HP:0000666)1.88941453
130Macroorchidism (HP:0000053)1.88707743
131Optic nerve hypoplasia (HP:0000609)1.87212309
132Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.87143117
133Poor coordination (HP:0002370)1.85999020
134EEG with generalized epileptiform discharges (HP:0011198)1.84945736
135Absent radius (HP:0003974)1.84856133
136Small hand (HP:0200055)1.83829561
137Abnormal atrioventricular conduction (HP:0005150)1.83499025
138Cystic liver disease (HP:0006706)1.83308821
139Vitreoretinal degeneration (HP:0000655)1.82522514
140Type 2 muscle fiber atrophy (HP:0003554)1.82104972
141Polyuria (HP:0000103)1.81950741
142Fatigable weakness (HP:0003473)1.81572439
143Abnormality of the neuromuscular junction (HP:0003398)1.81572439
144Absent septum pellucidum (HP:0001331)1.77445143
145Generalized tonic-clonic seizures (HP:0002069)1.77338033
146Aplasia involving forearm bones (HP:0009822)1.75277283
147Absent forearm bone (HP:0003953)1.75277283
148Epileptiform EEG discharges (HP:0011182)1.75048574
149Aplasia/Hypoplasia of the tongue (HP:0010295)1.73638898
150Epiphyseal stippling (HP:0010655)1.73471497
151Aplasia/Hypoplasia of the lens (HP:0008063)1.73006103
152Genetic anticipation (HP:0003743)1.72133473
153Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71348333
154Pancreatic cysts (HP:0001737)1.71060312
155Abnormal EKG (HP:0003115)1.70801540
156Molar tooth sign on MRI (HP:0002419)1.70552910
157Abnormality of midbrain morphology (HP:0002418)1.70552910
158Aplasia/hypoplasia of the humerus (HP:0006507)1.69365568
159Depression (HP:0000716)1.68973914
160Abnormality of the common coagulation pathway (HP:0010990)1.67813397
161Hepatoblastoma (HP:0002884)1.67413375
162Abdominal situs inversus (HP:0003363)1.66361262
163Abnormality of abdominal situs (HP:0011620)1.66361262
164Abnormal pupillary function (HP:0007686)1.65680460
165Neoplasm of the heart (HP:0100544)1.63278009
166Truncal ataxia (HP:0002078)1.63100267
167Vaginal atresia (HP:0000148)1.61577008
168Subcapsular cataract (HP:0000523)1.61297853
169Genital tract atresia (HP:0001827)1.60727948
170Volvulus (HP:0002580)1.60318181
171Astigmatism (HP:0000483)1.58828471
172Abnormality of the septum pellucidum (HP:0007375)1.57274055
173Bilateral microphthalmos (HP:0007633)1.55550517
174Hypochromic microcytic anemia (HP:0004840)1.53796774
175Hyperinsulinemic hypoglycemia (HP:0000825)1.53683138
176Decreased electroretinogram (ERG) amplitude (HP:0000654)1.51759293
177Wide nasal bridge (HP:0000431)1.51692737
178Hand muscle atrophy (HP:0009130)1.48626967
179Astrocytoma (HP:0009592)1.43256310
180Abnormality of the astrocytes (HP:0100707)1.43256310
181Excessive salivation (HP:0003781)1.42041488
182Drooling (HP:0002307)1.42041488
183Hyperventilation (HP:0002883)1.41353148
184Chorioretinal coloboma (HP:0000567)1.40407227
185Generalized hypopigmentation (HP:0007513)1.39707146
186Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.39015413
187Scanning speech (HP:0002168)1.37706542
188Neoplasm of the oral cavity (HP:0100649)1.36877368
189Bifid tongue (HP:0010297)1.33615087

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK158.18171463
2WNK44.76209632
3GRK13.88308877
4CDK123.78710655
5PBK3.77280826
6DAPK23.19923988
7INSRR3.19346558
8ACVR1B3.03643877
9MUSK2.97596621
10BLK2.76907570
11NEK12.59841067
12STK382.47672464
13GRK52.36027268
14BMPR1B2.31844794
15MARK12.23987983
16PAK62.10149179
17TAOK22.07324083
18HIPK21.99143221
19AKT31.92828219
20PRPF4B1.89199576
21MAP3K41.88629799
22TESK21.88036729
23NTRK31.84049607
24CAMK1D1.77364283
25TLK11.74661114
26PINK11.72544924
27CAMK1G1.67532171
28RIPK11.65545084
29DYRK1A1.65268908
30MAP3K71.59670295
31PHKG21.59645659
32PHKG11.59645659
33CDK31.52822472
34WNK11.48133392
35BRD41.42188570
36PRKD31.42010673
37FES1.41266285
38STK38L1.39657012
39ZAK1.38686500
40WNK31.30882299
41CCNB11.30260033
42MAPK71.26789105
43PDPK11.26004587
44MINK11.15418827
45NTRK11.14902846
46PRKAA11.14610304
47BMX1.12232753
48PRKG21.11011811
49ERN11.09814291
50CAMK2D1.07351180
51PRKCH1.07159894
52ZAP701.06766805
53ADRBK21.00674379
54CDK11A1.00333472
55MAP2K60.99872868
56PRKD20.99744509
57SGK2230.97150964
58SGK4940.97150964
59TAOK30.96269250
60MAP2K70.95138719
61CAMK40.94872963
62NTRK20.91281538
63MARK20.90527556
64FER0.89012208
65MAP3K90.88641029
66CAMK10.87659296
67PAK30.86179852
68STK160.86103270
69ERBB30.84551795
70PRKCZ0.83494820
71DYRK1B0.82995242
72IRAK20.81628061
73MAP2K40.80411886
74MAPK100.79768871
75SIK20.78506067
76MAPK130.75054613
77CASK0.74916064
78FRK0.73709857
79STK110.72338628
80NEK60.72208062
81ERBB20.71901605
82EPHA30.71649650
83CSNK1D0.70899100
84PRKD10.70390791
85MAPK110.69816501
86CDK90.69571625
87SIK10.68613838
88PRKCB0.68186322
89SGK20.67757299
90GSK3B0.67484093
91TGFBR10.66987480
92MST1R0.66663173
93CHEK20.66576258
94RPS6KA20.66568762
95PIM20.65246475
96NME10.64060122
97ICK0.63339430
98RPS6KA30.62513330
99OBSCN0.62487022
100CAMKK20.61336348
101STK390.60444956
102CDK50.59826361
103OXSR10.59722131
104CDC42BPA0.59309513
105PRKCA0.58133992
106TNK20.57779127
107PRKG10.56456590
108MELK0.56434110
109CDK140.55869439
110TRIB30.55761487
111GRK70.54757563
112MAPK140.54144528
113CDK40.54133355
114ADRBK10.54076226
115PDK10.53848548
116MAP3K60.53221576
117KSR20.52761623
118PRKCG0.52246566
119TNIK0.52195075
120RPS6KA60.51966631
121PRKACA0.51670200
122NEK20.51519093
123CSNK1E0.50378581
124GRK60.50272553
125PKN10.49827933
126CDK150.49685472
127MAP3K130.49498309
128CAMKK10.49401815
129PRKCE0.49211801
130EPHA40.48834075
131PRKAA20.48673837
132MAP2K30.48546059
133MAPK120.48241291
134MAP2K10.48142561
135MAPK90.46693160
136RAF10.46479932
137MAPK10.46116482
138MATK0.46085852
139MAPK80.45893232
140CDK180.45497496
141CDK10.45389536
142SGK30.45298964
143MTOR0.45105291
144ARAF0.42853141
145TYRO30.37565830
146SGK10.35160032
147AURKA0.34812743
148AKT20.32909758
149CAMK2A0.31758038
150RPS6KL10.30836378
151RPS6KC10.30836378
152RPS6KB10.30340538
153RPS6KA50.28294231
154ROCK10.26871951

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047446.34989719
2Sulfur relay system_Homo sapiens_hsa041224.99762597
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.83071009
4GABAergic synapse_Homo sapiens_hsa047273.74201965
5Nicotine addiction_Homo sapiens_hsa050333.27595465
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.26212890
7Synaptic vesicle cycle_Homo sapiens_hsa047213.15634758
8Morphine addiction_Homo sapiens_hsa050322.88604086
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.67330420
10Insulin secretion_Homo sapiens_hsa049112.52581053
11Circadian rhythm_Homo sapiens_hsa047102.50779597
12Olfactory transduction_Homo sapiens_hsa047402.32388307
13Circadian entrainment_Homo sapiens_hsa047132.27593913
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.19781310
15Glycosaminoglycan degradation_Homo sapiens_hsa005312.00676275
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.92434019
17Fructose and mannose metabolism_Homo sapiens_hsa000511.90877669
18Glutamatergic synapse_Homo sapiens_hsa047241.89504396
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.88463164
20Salivary secretion_Homo sapiens_hsa049701.80519394
21Sphingolipid metabolism_Homo sapiens_hsa006001.80348190
22Serotonergic synapse_Homo sapiens_hsa047261.66681694
23Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.65098522
24Cholinergic synapse_Homo sapiens_hsa047251.63331609
25Renin secretion_Homo sapiens_hsa049241.57067086
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.49249580
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48267453
28Dopaminergic synapse_Homo sapiens_hsa047281.40663365
29Oxytocin signaling pathway_Homo sapiens_hsa049211.40065334
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.35019128
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33146472
32Taste transduction_Homo sapiens_hsa047421.32316869
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.29473389
34mTOR signaling pathway_Homo sapiens_hsa041501.23962015
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.23438979
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.22217821
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.21666894
38Dilated cardiomyopathy_Homo sapiens_hsa054141.19609542
39Carbohydrate digestion and absorption_Homo sapiens_hsa049731.18977446
40Galactose metabolism_Homo sapiens_hsa000521.16153544
41Hedgehog signaling pathway_Homo sapiens_hsa043401.14411698
42Cardiac muscle contraction_Homo sapiens_hsa042601.13425763
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11152601
44Thyroid hormone signaling pathway_Homo sapiens_hsa049191.10437660
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08828068
46Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.05004592
47Type II diabetes mellitus_Homo sapiens_hsa049301.04920359
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04374143
49Vascular smooth muscle contraction_Homo sapiens_hsa042701.04341982
50Calcium signaling pathway_Homo sapiens_hsa040200.98655451
51Vitamin digestion and absorption_Homo sapiens_hsa049770.97326764
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95268498
53Long-term depression_Homo sapiens_hsa047300.91131917
54Fanconi anemia pathway_Homo sapiens_hsa034600.89605140
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89116985
56Inositol phosphate metabolism_Homo sapiens_hsa005620.88177111
57cAMP signaling pathway_Homo sapiens_hsa040240.85311407
58Gap junction_Homo sapiens_hsa045400.83392352
59ABC transporters_Homo sapiens_hsa020100.82243418
60Amphetamine addiction_Homo sapiens_hsa050310.81500647
61Long-term potentiation_Homo sapiens_hsa047200.79668986
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76197528
63Gastric acid secretion_Homo sapiens_hsa049710.75139385
64Pentose phosphate pathway_Homo sapiens_hsa000300.75081755
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74298030
66Pancreatic secretion_Homo sapiens_hsa049720.74108039
67Mineral absorption_Homo sapiens_hsa049780.73492052
68Vibrio cholerae infection_Homo sapiens_hsa051100.71771370
69GnRH signaling pathway_Homo sapiens_hsa049120.71628809
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66489623
71Hippo signaling pathway_Homo sapiens_hsa043900.64020855
72Nitrogen metabolism_Homo sapiens_hsa009100.62725917
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.62623063
74Arginine biosynthesis_Homo sapiens_hsa002200.62023970
75Biosynthesis of amino acids_Homo sapiens_hsa012300.60168951
76Collecting duct acid secretion_Homo sapiens_hsa049660.59625568
77Vitamin B6 metabolism_Homo sapiens_hsa007500.59548124
78Fatty acid biosynthesis_Homo sapiens_hsa000610.57759038
79Thyroid hormone synthesis_Homo sapiens_hsa049180.57649789
80Choline metabolism in cancer_Homo sapiens_hsa052310.57440857
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57036464
82Cocaine addiction_Homo sapiens_hsa050300.54090787
83MAPK signaling pathway_Homo sapiens_hsa040100.52098079
84Dorso-ventral axis formation_Homo sapiens_hsa043200.50252662
85African trypanosomiasis_Homo sapiens_hsa051430.50129389
86HIF-1 signaling pathway_Homo sapiens_hsa040660.49289815
87Pyruvate metabolism_Homo sapiens_hsa006200.48401732
88Glycerolipid metabolism_Homo sapiens_hsa005610.47957564
89Glioma_Homo sapiens_hsa052140.47688731
90Histidine metabolism_Homo sapiens_hsa003400.45777561
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42433829
92Alcoholism_Homo sapiens_hsa050340.41770016
93Lysine degradation_Homo sapiens_hsa003100.41099789
94Lysosome_Homo sapiens_hsa041420.41080147
95Basal cell carcinoma_Homo sapiens_hsa052170.40728723
96Wnt signaling pathway_Homo sapiens_hsa043100.40210044
97ErbB signaling pathway_Homo sapiens_hsa040120.39993931
98Glucagon signaling pathway_Homo sapiens_hsa049220.38875148
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37250441
100Chemical carcinogenesis_Homo sapiens_hsa052040.37040609
101Bile secretion_Homo sapiens_hsa049760.36986725
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36911345
103AMPK signaling pathway_Homo sapiens_hsa041520.36571331
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35867716
105Renin-angiotensin system_Homo sapiens_hsa046140.34278092
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34004378
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33871629
108Other glycan degradation_Homo sapiens_hsa005110.33825952
109Melanogenesis_Homo sapiens_hsa049160.33613968
110Non-small cell lung cancer_Homo sapiens_hsa052230.32951768
111Endocytosis_Homo sapiens_hsa041440.32924922
112Linoleic acid metabolism_Homo sapiens_hsa005910.32596806
113Ras signaling pathway_Homo sapiens_hsa040140.32544994
114Ether lipid metabolism_Homo sapiens_hsa005650.32082193
115Ovarian steroidogenesis_Homo sapiens_hsa049130.31484050
116Axon guidance_Homo sapiens_hsa043600.30756309
1172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30189855
118Renal cell carcinoma_Homo sapiens_hsa052110.27682647
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.27577391
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.27061339
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26790622
122Fatty acid degradation_Homo sapiens_hsa000710.26037263
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25302534
124Phenylalanine metabolism_Homo sapiens_hsa003600.24514345
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24035819
126Insulin resistance_Homo sapiens_hsa049310.23986956
127RNA polymerase_Homo sapiens_hsa030200.23957878
128Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22135253
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21503263
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.19096972
131Protein digestion and absorption_Homo sapiens_hsa049740.18168008
132Endometrial cancer_Homo sapiens_hsa052130.17563626
133Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.17390905
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17067341
135Arginine and proline metabolism_Homo sapiens_hsa003300.16906296
136Rap1 signaling pathway_Homo sapiens_hsa040150.16263444
137Colorectal cancer_Homo sapiens_hsa052100.16038138
138VEGF signaling pathway_Homo sapiens_hsa043700.15790513
139Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.14782184

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