GPR176

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the G protein-coupled receptor family, such as GPR176, are cell surface receptors involved in responses to hormones, growth factors, and neurotransmitters (Hata et al., 1995 [PubMed 7893747]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of extracellular ligand from receptor (GO:0035581)5.78793551
2chondrocyte proliferation (GO:0035988)5.38910706
3paraxial mesoderm development (GO:0048339)5.23099130
4collagen fibril organization (GO:0030199)4.95272822
5regulation of posttranscriptional gene silencing (GO:0060147)4.93935019
6regulation of gene silencing by miRNA (GO:0060964)4.93935019
7regulation of gene silencing by RNA (GO:0060966)4.93935019
8regulation of cell fate specification (GO:0042659)4.36127202
9positive regulation of SMAD protein import into nucleus (GO:0060391)4.30366378
10cell migration involved in sprouting angiogenesis (GO:0002042)4.18223886
11dermatan sulfate biosynthetic process (GO:0030208)4.11433606
12protein complex localization (GO:0031503)4.00433416
13extracellular matrix assembly (GO:0085029)3.99900382
14cell adhesion mediated by integrin (GO:0033627)3.99594619
15planar cell polarity pathway involved in neural tube closure (GO:0090179)3.94338945
16establishment of integrated proviral latency (GO:0075713)3.91846372
17extracellular fibril organization (GO:0043206)3.88932007
18peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.84915628
19dermatan sulfate metabolic process (GO:0030205)3.80788852
20protein heterotrimerization (GO:0070208)3.77570203
21central nervous system myelination (GO:0022010)3.77233536
22axon ensheathment in central nervous system (GO:0032291)3.77233536
23endothelial cell morphogenesis (GO:0001886)3.76027894
24L-serine metabolic process (GO:0006563)3.63082495
25regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.62272857
26convergent extension (GO:0060026)3.59866258
27bone trabecula formation (GO:0060346)3.58970764
28mesenchymal-epithelial cell signaling (GO:0060638)3.56568234
29positive regulation of fibroblast migration (GO:0010763)3.55386842
30anterior/posterior axis specification, embryo (GO:0008595)3.53986120
31actin filament depolymerization (GO:0030042)3.50615473
32skin morphogenesis (GO:0043589)3.47643662
33wound healing, spreading of epidermal cells (GO:0035313)3.39911133
34adhesion of symbiont to host cell (GO:0044650)3.38463874
35virion attachment to host cell (GO:0019062)3.38463874
36pre-miRNA processing (GO:0031054)3.38195481
37fibril organization (GO:0097435)3.36962895
38negative regulation of fibroblast apoptotic process (GO:2000270)3.36847749
39G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.32134863
40cellular protein complex localization (GO:0034629)3.30858180
41negative regulation of synaptic transmission, GABAergic (GO:0032229)3.29336311
42fatty acid elongation (GO:0030497)3.29128565
43synaptic vesicle maturation (GO:0016188)3.26736650
44endodermal cell differentiation (GO:0035987)3.25916845
45protein targeting to plasma membrane (GO:0072661)3.25589467
46craniofacial suture morphogenesis (GO:0097094)3.23655086
47extracellular negative regulation of signal transduction (GO:1900116)3.23032847
48extracellular regulation of signal transduction (GO:1900115)3.23032847
49inner ear receptor cell development (GO:0060119)3.20577239
50regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.18532614
51regulation of SMAD protein import into nucleus (GO:0060390)3.18522536
52heterochromatin organization (GO:0070828)3.17482686
53heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.13612036
54long-chain fatty acid biosynthetic process (GO:0042759)3.11662585
55negative regulation of chondrocyte differentiation (GO:0032331)3.10291163
56establishment of apical/basal cell polarity (GO:0035089)3.09383335
57glomerular visceral epithelial cell development (GO:0072015)3.08570255
58negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.05635096
59adherens junction assembly (GO:0034333)3.04544536
60establishment of viral latency (GO:0019043)3.04189014
61vocalization behavior (GO:0071625)3.03566361
62wound healing, spreading of cells (GO:0044319)3.01781995
63response to redox state (GO:0051775)3.01224004
64positive regulation of osteoblast proliferation (GO:0033690)3.01038399
65negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.00783986
66axon extension involved in axon guidance (GO:0048846)2.97499775
67neuron projection extension involved in neuron projection guidance (GO:1902284)2.97499775
68positive regulation of endothelial cell apoptotic process (GO:2000353)2.96129291
69positive regulation of actin filament depolymerization (GO:0030836)2.96060780
70lung-associated mesenchyme development (GO:0060484)2.91375927
71notochord development (GO:0030903)2.91041832
72protein localization to cell surface (GO:0034394)2.89800136
73type B pancreatic cell proliferation (GO:0044342)2.88485080
74cell fate commitment involved in formation of primary germ layer (GO:0060795)2.87990829
75protein retention in ER lumen (GO:0006621)2.87927534
76cellular response to vitamin D (GO:0071305)2.87630475
77hippo signaling (GO:0035329)2.87311050
78positive regulation of catenin import into nucleus (GO:0035413)2.84427184
79negative regulation of focal adhesion assembly (GO:0051895)2.82398259
80negative regulation of cell junction assembly (GO:1901889)2.82398259
81negative regulation of adherens junction organization (GO:1903392)2.82398259
82cell-substrate adherens junction assembly (GO:0007045)2.81524681
83focal adhesion assembly (GO:0048041)2.81524681
84substrate-dependent cell migration (GO:0006929)2.80804836
85protein localization to kinetochore (GO:0034501)2.80742808
86positive regulation of axon extension (GO:0045773)2.79956070
87cranial suture morphogenesis (GO:0060363)2.79285196
88negative regulation of osteoblast proliferation (GO:0033689)2.79026459
89maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.78965823
90Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.77937511
91collagen metabolic process (GO:0032963)2.77839782
92negative regulation of smooth muscle cell migration (GO:0014912)2.77833637
93collagen catabolic process (GO:0030574)2.77442436
94membrane assembly (GO:0071709)2.77166725
95negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.76632356
96outer ear morphogenesis (GO:0042473)2.76118158
97myelination (GO:0042552)2.74920047
98negative regulation of leukocyte chemotaxis (GO:0002689)2.74445366
99regulation of short-term neuronal synaptic plasticity (GO:0048172)2.74155392
100metanephric mesenchyme development (GO:0072075)2.73454010
101axon ensheathment (GO:0008366)2.72099880
102ensheathment of neurons (GO:0007272)2.72099880
103neuron cell-cell adhesion (GO:0007158)2.71247108
104positive regulation of synapse assembly (GO:0051965)2.71061684
105regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.69118471
106histone arginine methylation (GO:0034969)2.66426822
107regulation of gastrulation (GO:0010470)2.66070857
108nucleotide-sugar biosynthetic process (GO:0009226)2.65262361
109establishment of monopolar cell polarity (GO:0061162)2.65147085
110establishment or maintenance of monopolar cell polarity (GO:0061339)2.65147085
111negative regulation of fatty acid transport (GO:2000192)2.64981092
112cell migration involved in heart development (GO:0060973)2.64252601
113regulation of establishment of planar polarity (GO:0090175)2.63479954
114membrane raft organization (GO:0031579)2.62994287
115nuclear pore complex assembly (GO:0051292)2.62953490
116lymphangiogenesis (GO:0001946)2.62710579
117peptidyl-proline hydroxylation (GO:0019511)2.62523248
118negative regulation of androgen receptor signaling pathway (GO:0060766)2.62506478
119blood vessel endothelial cell migration (GO:0043534)2.61075863
120substrate adhesion-dependent cell spreading (GO:0034446)2.60836141
121cell-substrate junction assembly (GO:0007044)2.60834207
122glomerular epithelial cell development (GO:0072310)2.60800124
123regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.60750070
124synaptic vesicle exocytosis (GO:0016079)2.60614421
125cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.60526328
126negative regulation of cell fate specification (GO:0009996)2.59924915
127regulation of monocyte chemotaxis (GO:0090025)2.58670601
128endocardial cushion development (GO:0003197)2.57466345
129multicellular organismal macromolecule metabolic process (GO:0044259)2.56927684
130kidney mesenchyme development (GO:0072074)2.56441648
131regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.55743991
132regulation of fibroblast migration (GO:0010762)2.54018742
133neuron recognition (GO:0008038)2.53335088
134chondrocyte development (GO:0002063)2.52988382
135establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.51422772
136axon extension (GO:0048675)2.51299203
137negative regulation of axonogenesis (GO:0050771)2.51265505
138stress fiber assembly (GO:0043149)2.50706214
139regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.50161810
140DNA unwinding involved in DNA replication (GO:0006268)2.50085443
141locomotory exploration behavior (GO:0035641)2.50009589
142presynaptic membrane assembly (GO:0097105)2.50004419
143heparan sulfate proteoglycan metabolic process (GO:0030201)2.49417397
144negative regulation of cardiac muscle tissue development (GO:0055026)2.49071644
145short-term memory (GO:0007614)2.48992718
146regulation of cell fate commitment (GO:0010453)2.48128767
147multicellular organismal catabolic process (GO:0044243)2.46992408
148ventricular cardiac muscle cell development (GO:0055015)2.46895327
149negative regulation of BMP signaling pathway (GO:0030514)2.46601927
150plasma membrane repair (GO:0001778)2.46437541
151negative chemotaxis (GO:0050919)2.44550004
152dendrite morphogenesis (GO:0048813)2.44246803
153negative regulation of embryonic development (GO:0045992)2.43912414
154presynaptic membrane organization (GO:0097090)2.43080574
155protein neddylation (GO:0045116)2.42977165
156adhesion of symbiont to host (GO:0044406)2.42283657
157positive regulation of macrophage activation (GO:0043032)2.41642037
158regulation of catenin import into nucleus (GO:0035412)2.41139828
159non-canonical Wnt signaling pathway (GO:0035567)2.40950124
160regulation of axon extension involved in axon guidance (GO:0048841)2.40793224
161regulation of tight junction assembly (GO:2000810)2.40752368
162glutamate secretion (GO:0014047)2.40738358
163retina vasculature morphogenesis in camera-type eye (GO:0061299)2.40446850
164response to follicle-stimulating hormone (GO:0032354)2.39970032
165extracellular matrix disassembly (GO:0022617)2.39004811
166extracellular matrix organization (GO:0030198)2.38822843
167axonal fasciculation (GO:0007413)2.37937302
168extracellular structure organization (GO:0043062)2.37627830
169multicellular organismal metabolic process (GO:0044236)2.37455917
170negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.36752017
171negative regulation of neurotransmitter transport (GO:0051589)2.32815498
172regulation of axon guidance (GO:1902667)2.32441136
173astrocyte development (GO:0014002)2.31718776
174cellular response to vitamin (GO:0071295)2.30975410
175regulation of transforming growth factor beta1 production (GO:0032908)2.30063056

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.21689711
2E2F7_22180533_ChIP-Seq_HELA_Human4.54770265
3POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.46318801
4GBX2_23144817_ChIP-Seq_PC3_Human3.20858689
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.14672017
6ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.94190577
7* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.82827475
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.70340893
9* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.64543217
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.55848042
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54540572
12* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.48611058
13* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.48611058
14SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.48172716
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40971294
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38298056
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.38286998
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.38286998
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.38286998
20* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.35902555
21HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.33617107
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.29786597
23TCF3_18692474_ChIP-Seq_MEFs_Mouse2.28604501
24SMAD_19615063_ChIP-ChIP_OVARY_Human2.26310808
25NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.22295019
26JARID2_20075857_ChIP-Seq_MESCs_Mouse2.20641801
27NRF2_20460467_ChIP-Seq_MEFs_Mouse2.20184110
28NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.20184110
29WT1_19549856_ChIP-ChIP_CCG9911_Human2.17882653
30* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.15741767
31ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.12345373
32EZH2_22144423_ChIP-Seq_EOC_Human2.08945070
33* EZH2_27304074_Chip-Seq_ESCs_Mouse2.08256857
34FOXM1_23109430_ChIP-Seq_U2OS_Human2.06378486
35CJUN_26792858_Chip-Seq_BT549_Human2.06019713
36POU5F1_16153702_ChIP-ChIP_HESCs_Human2.04081025
37* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.98765268
38NANOG_16153702_ChIP-ChIP_HESCs_Human1.95620944
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.91333827
40AR_21909140_ChIP-Seq_LNCAP_Human1.89693710
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.89592380
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.88470061
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87627881
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.86505359
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.85684285
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.83031605
47TP53_18474530_ChIP-ChIP_U2OS_Human1.80987815
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.79577420
49* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.78423059
50SOX2_16153702_ChIP-ChIP_HESCs_Human1.77542042
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74578263
52EP300_21415370_ChIP-Seq_HL-1_Mouse1.73041595
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.71747282
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.70107553
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.69878780
56EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.69701441
57CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.68962243
58AR_21572438_ChIP-Seq_LNCaP_Human1.67321759
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65671507
60RNF2_27304074_Chip-Seq_ESCs_Mouse1.64843443
61TCF3_18692474_ChIP-Seq_MESCs_Mouse1.64096096
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62409246
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.60544201
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58990819
65TP53_16413492_ChIP-PET_HCT116_Human1.58219902
66SUZ12_27294783_Chip-Seq_ESCs_Mouse1.57734820
67SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.53296272
68DROSHA_22980978_ChIP-Seq_HELA_Human1.51670140
69TBX3_20139965_ChIP-Seq_ESCs_Mouse1.49810615
70JUN_21703547_ChIP-Seq_K562_Human1.49683481
71SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.49638969
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49021298
73TBX3_20139965_ChIP-Seq_MESCs_Mouse1.48580848
74MYC_19030024_ChIP-ChIP_MESCs_Mouse1.48332999
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47527985
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47435500
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.47023880
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45763685
79* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.45085873
80TAF15_26573619_Chip-Seq_HEK293_Human1.44388910
81ER_23166858_ChIP-Seq_MCF-7_Human1.43485981
82* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41373465
83NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40018164
84P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33132591
85GATA1_26923725_Chip-Seq_HPCs_Mouse1.33098494
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32594412
87ZNF274_21170338_ChIP-Seq_K562_Hela1.32019126
88TP53_20018659_ChIP-ChIP_R1E_Mouse1.31665001
89TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.31305705
90SMAD4_21799915_ChIP-Seq_A2780_Human1.31044406
91POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.29148124
92SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28815289
93TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.28711580
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28176007
95NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.27681290
96P300_19829295_ChIP-Seq_ESCs_Human1.25937310
97SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.25481681
98NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25250568
99GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24266900
100SOX2_18692474_ChIP-Seq_MEFs_Mouse1.23702010
101ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23240301
102EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.23023816
103BRD4_25478319_ChIP-Seq_HGPS_Human1.22491240
104ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20902462
105ISL1_27105846_Chip-Seq_CPCs_Mouse1.20274235
106E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19807739
107KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19038601
108ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19031410
109TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18298304
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17870492
111MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17304613
112* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16562989
113IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16096118
114EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16085183
115SOX17_20123909_ChIP-Seq_XEN_Mouse1.15730181
116E2F4_17652178_ChIP-ChIP_JURKAT_Human1.15338174
117NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.15184102
118FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.14868361
119BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14645953
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14448648
121CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13610122
122TP63_17297297_ChIP-ChIP_HaCaT_Human1.13371753
123CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13175692
124TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13084635
125NANOG_18692474_ChIP-Seq_MEFs_Mouse1.12948896
126MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12179469
127KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12088002
128ERG_21242973_ChIP-ChIP_JURKAT_Human1.11691711
129TP53_22127205_ChIP-Seq_IMR90_Human1.11506125
130* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10989530
131DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09252745
132NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08794284
133* TP53_23651856_ChIP-Seq_MEFs_Mouse1.08727134
134SOX2_20726797_ChIP-Seq_SW620_Human1.08512928
135AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06133988
136NANOG_21062744_ChIP-ChIP_HESCs_Human1.05402040
137TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05001348
138HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04680442
139DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04563158
140SMC1_22415368_ChIP-Seq_MEFs_Mouse1.02528360
141SOX2_18692474_ChIP-Seq_MESCs_Mouse1.01822222
142ELK3_25401928_ChIP-Seq_HUVEC_Human1.01678555
143ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01632829
144OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01566955
145* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01246793
146SA1_22415368_ChIP-Seq_MEFs_Mouse1.00769979
147CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00694674
148* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00532110
149RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00237049
150SMAD3_21741376_ChIP-Seq_EPCs_Human1.00078091
151NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.99060377
152SOX2_21211035_ChIP-Seq_LN229_Gbm0.98617177
153EOMES_21245162_ChIP-Seq_HESCs_Human0.97593004
154NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97143474
155POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97117535
156UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96604333
157CBX2_27304074_Chip-Seq_ESCs_Mouse0.96268704
158CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95262287
159CLOCK_20551151_ChIP-Seq_293T_Human0.95048245
160NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94923650
161FUS_26573619_Chip-Seq_HEK293_Human0.94905658
162NANOG_16518401_ChIP-PET_MESCs_Mouse0.93851629
163* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93099308
164CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92877302
165RXR_22108803_ChIP-Seq_LS180_Human0.90719125
166* RING1B_27294783_Chip-Seq_ESCs_Mouse0.90350527
167RING1B_27294783_Chip-Seq_NPCs_Mouse0.89968368
168PRDM14_20953172_ChIP-Seq_ESCs_Human0.89784078
169AR_25329375_ChIP-Seq_VCAP_Human0.89154702
170* STAT3_23295773_ChIP-Seq_U87_Human0.88375898
171TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86051507
172KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.84960081
173MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84586747
174* RUNX2_22187159_ChIP-Seq_PCA_Human0.84276552
175WT1_25993318_ChIP-Seq_PODOCYTE_Human0.83989965
176* PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.83739695

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.59374193
2MP0005503_abnormal_tendon_morphology4.60730376
3MP0005275_abnormal_skin_tensile4.13059475
4MP0002254_reproductive_system_inflammat4.03821258
5MP0003941_abnormal_skin_development3.96171050
6MP0003279_aneurysm3.91433365
7MP0001958_emphysema3.63757469
8MP0005623_abnormal_meninges_morphology3.17220002
9MP0003705_abnormal_hypodermis_morpholog2.69580264
10MP0009384_cardiac_valve_regurgitation2.61318796
11MP0002295_abnormal_pulmonary_circulatio2.58852394
12MP0004859_abnormal_synaptic_plasticity2.47234222
13MP0001542_abnormal_bone_strength2.09514520
14MP0001299_abnormal_eye_distance/2.07897867
15MP0004272_abnormal_basement_membrane1.95762524
16MP0000013_abnormal_adipose_tissue1.93260936
17MP0005257_abnormal_intraocular_pressure1.91563401
18MP0001348_abnormal_lacrimal_gland1.90631942
19MP0005508_abnormal_skeleton_morphology1.84570699
20MP0009250_abnormal_appendicular_skeleto1.81484399
21MP0003880_abnormal_central_pattern1.79258912
22MP0000920_abnormal_myelination1.73412937
23MP0003091_abnormal_cell_migration1.73314197
24MP0004134_abnormal_chest_morphology1.68526801
25MP0005171_absent_coat_pigmentation1.61188394
26MP0006054_spinal_hemorrhage1.59697463
27MP0001849_ear_inflammation1.58669585
28MP0001177_atelectasis1.58620399
29MP0004270_analgesia1.58449900
30MP0002108_abnormal_muscle_morphology1.53717041
31MP0003937_abnormal_limbs/digits/tail_de1.49513478
32MP0003329_amyloid_beta_deposits1.48498612
33MP0003385_abnormal_body_wall1.47432773
34MP0000428_abnormal_craniofacial_morphol1.43820403
35MP0009046_muscle_twitch1.43277840
36MP0003950_abnormal_plasma_membrane1.42429968
37MP0008932_abnormal_embryonic_tissue1.41405402
38MP0009672_abnormal_birth_weight1.40820561
39MP0000049_abnormal_middle_ear1.40134954
40MP0003635_abnormal_synaptic_transmissio1.39745099
41MP0004957_abnormal_blastocyst_morpholog1.38383581
42MP0003566_abnormal_cell_adhesion1.37415987
43MP0002064_seizures1.35307028
44MP0005023_abnormal_wound_healing1.33570887
45MP0005595_abnormal_vascular_smooth1.30503025
46MP0001968_abnormal_touch/_nociception1.27190181
47MP0009745_abnormal_behavioral_response1.24897221
48MP0001243_abnormal_dermal_layer1.20776290
49MP0002272_abnormal_nervous_system1.19630821
50MP0002697_abnormal_eye_size1.19187092
51MP0002736_abnormal_nociception_after1.15606525
52MP0003111_abnormal_nucleus_morphology1.15262904
53MP0000432_abnormal_head_morphology1.14794816
54MP0002085_abnormal_embryonic_tissue1.14601492
55MP0002734_abnormal_mechanical_nocicepti1.14517949
56MP0000778_abnormal_nervous_system1.14284799
57MP0004858_abnormal_nervous_system1.13340991
58MP0010030_abnormal_orbit_morphology1.11541880
59MP0002063_abnormal_learning/memory/cond1.10276976
60MP0002060_abnormal_skin_morphology1.10271228
61MP0002133_abnormal_respiratory_system1.08918681
62MP0005388_respiratory_system_phenotype1.08918681
63MP0001730_embryonic_growth_arrest1.08827145
64MP0000537_abnormal_urethra_morphology1.07211803
65MP0002084_abnormal_developmental_patter1.06454005
66MP0003693_abnormal_embryo_hatching1.05766191
67MP0009053_abnormal_anal_canal1.05713986
68MP0000762_abnormal_tongue_morphology1.04683185
69MP0003890_abnormal_embryonic-extraembry1.02132785
70MP0000003_abnormal_adipose_tissue1.01317424
71MP0001293_anophthalmia1.00100335
72MP0003634_abnormal_glial_cell1.00008584
73MP0002572_abnormal_emotion/affect_behav0.98998986
74MP0000767_abnormal_smooth_muscle0.98650000
75MP0001905_abnormal_dopamine_level0.98428387
76MP0005390_skeleton_phenotype0.97843558
77MP0002282_abnormal_trachea_morphology0.97676313
78MP0001915_intracranial_hemorrhage0.97537485
79MP0005164_abnormal_response_to0.97152458
80MP0003755_abnormal_palate_morphology0.96980973
81MP0002896_abnormal_bone_mineralization0.96522908
82MP0003115_abnormal_respiratory_system0.92887612
83MP0002735_abnormal_chemical_nociception0.92787635
84MP0004133_heterotaxia0.91546213
85MP0003045_fibrosis0.91120908
86MP0001501_abnormal_sleep_pattern0.89809364
87MP0009780_abnormal_chondrocyte_physiolo0.89754051
88MP0010368_abnormal_lymphatic_system0.89246200
89MP0004233_abnormal_muscle_weight0.89071802
90MP0001486_abnormal_startle_reflex0.89014915
91MP0009703_decreased_birth_body0.88859246
92MP0003283_abnormal_digestive_organ0.87804228
93MP0001440_abnormal_grooming_behavior0.86609291
94MP0005084_abnormal_gallbladder_morpholo0.85595324
95MP0003942_abnormal_urinary_system0.84906034
96MP0000350_abnormal_cell_proliferation0.84343279
97MP0004883_abnormal_blood_vessel0.83798929
98MP0005423_abnormal_somatic_nervous0.83262018
99MP0010352_gastrointestinal_tract_polyps0.83225430
100MP0003119_abnormal_digestive_system0.83217145
101MP0004142_abnormal_muscle_tone0.83140824
102MP0000163_abnormal_cartilage_morphology0.82787004
103MP0002168_other_aberrant_phenotype0.82340855
104MP0002111_abnormal_tail_morphology0.82167871
105MP0000534_abnormal_ureter_morphology0.81403648
106MP0001970_abnormal_pain_threshold0.81089774
107MP0003632_abnormal_nervous_system0.80957624
108MP0010386_abnormal_urinary_bladder0.80642059
109MP0001672_abnormal_embryogenesis/_devel0.79998035
110MP0005380_embryogenesis_phenotype0.79998035
111MP0000749_muscle_degeneration0.79152181
112MP0003567_abnormal_fetal_cardiomyocyte0.78848077
113MP0006276_abnormal_autonomic_nervous0.78169776
114MP0003935_abnormal_craniofacial_develop0.77717503
115MP0002116_abnormal_craniofacial_bone0.77134956
116MP0002933_joint_inflammation0.75925553
117MP0002733_abnormal_thermal_nociception0.75365609
118MP0002114_abnormal_axial_skeleton0.75290905
119MP0008007_abnormal_cellular_replicative0.74916241
120MP0000733_abnormal_muscle_development0.74814597
121MP0004197_abnormal_fetal_growth/weight/0.74567585
122MP0001286_abnormal_eye_development0.73929461
123MP0003861_abnormal_nervous_system0.73655636
124MP0002115_abnormal_skeleton_extremities0.73556576
125MP0002233_abnormal_nose_morphology0.73421105
126MP0004742_abnormal_vestibular_system0.73099222
127MP0004811_abnormal_neuron_physiology0.72780696
128MP0002080_prenatal_lethality0.72094632
129MP0000747_muscle_weakness0.69807243
130MP0002925_abnormal_cardiovascular_devel0.69693811
131MP0003448_altered_tumor_morphology0.69152338
132MP0000751_myopathy0.67806188
133MP0000462_abnormal_digestive_system0.67537132
134MP0002882_abnormal_neuron_morphology0.67524787
135MP0002932_abnormal_joint_morphology0.67260781
136MP0002092_abnormal_eye_morphology0.66885229
137MP0002066_abnormal_motor_capabilities/c0.66439973
138MP0003984_embryonic_growth_retardation0.66291668
139MP0000750_abnormal_muscle_regeneration0.65603228
140MP0008004_abnormal_stomach_pH0.65375435
141MP0003077_abnormal_cell_cycle0.65119745
142MP0001614_abnormal_blood_vessel0.64779578
143MP0001188_hyperpigmentation0.64387304
144MP0000955_abnormal_spinal_cord0.64200460
145MP0001879_abnormal_lymphatic_vessel0.64156855
146MP0001697_abnormal_embryo_size0.64018979
147MP0000759_abnormal_skeletal_muscle0.64009403
148MP0001529_abnormal_vocalization0.63890782
149MP0002128_abnormal_blood_circulation0.63425279
150MP0002067_abnormal_sensory_capabilities0.63300024
151MP0002184_abnormal_innervation0.63071988
152MP0005197_abnormal_uvea_morphology0.62986089
153MP0000604_amyloidosis0.61897472

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)8.38259305
2Protrusio acetabuli (HP:0003179)7.27584094
3Aortic dissection (HP:0002647)4.57804395
4Peritonitis (HP:0002586)4.41758472
5Aortic aneurysm (HP:0004942)4.36574562
6Soft skin (HP:0000977)4.28175356
7Abnormality of dentin (HP:0010299)4.22817616
8Bladder diverticulum (HP:0000015)4.00172401
9Atrophic scars (HP:0001075)3.95796215
10Dilatation of the ascending aorta (HP:0005111)3.94165525
11Wormian bones (HP:0002645)3.90242732
12Shallow orbits (HP:0000586)3.88960619
13Vascular tortuosity (HP:0004948)3.67023037
14Vertebral compression fractures (HP:0002953)3.45270338
15Fragile skin (HP:0001030)3.37939816
16Broad metatarsal (HP:0001783)3.25602972
17Infantile muscular hypotonia (HP:0008947)3.25259474
18Cerebral aneurysm (HP:0004944)3.21545995
19Slender build (HP:0001533)3.17889298
20Biconcave vertebral bodies (HP:0004586)3.08261945
21Blue sclerae (HP:0000592)3.02077451
22Genu recurvatum (HP:0002816)2.95031996
23Bowel diverticulosis (HP:0005222)2.90127357
24Spinal rigidity (HP:0003306)2.88206954
25Cervical subluxation (HP:0003308)2.79980660
26Neonatal short-limb short stature (HP:0008921)2.76739730
27Overgrowth (HP:0001548)2.73326828
28Hyperextensible skin (HP:0000974)2.64484504
29Coronal craniosynostosis (HP:0004440)2.60933669
30Abnormal delivery (HP:0001787)2.58853328
31Delayed gross motor development (HP:0002194)2.56512741
32Atonic seizures (HP:0010819)2.50466212
33Wrist flexion contracture (HP:0001239)2.46095218
34Ankle contracture (HP:0006466)2.44350299
35Short nail (HP:0001799)2.43193450
36Bell-shaped thorax (HP:0001591)2.41091852
37Limb-girdle muscle weakness (HP:0003325)2.39543879
38Ulnar bowing (HP:0003031)2.38102277
39Aplasia involving bones of the upper limbs (HP:0009823)2.35562366
40Aplasia of the phalanges of the hand (HP:0009802)2.35562366
41Aplasia involving bones of the extremities (HP:0009825)2.35562366
42Mildly elevated creatine phosphokinase (HP:0008180)2.30788713
43Arterial tortuosity (HP:0005116)2.29794861
44Spastic diplegia (HP:0001264)2.29685101
45Neurofibrillary tangles (HP:0002185)2.29313051
46Renal duplication (HP:0000075)2.27761695
47Buphthalmos (HP:0000557)2.26456067
48Broad long bones (HP:0005622)2.23711021
49Mitral regurgitation (HP:0001653)2.23548384
50Mesomelia (HP:0003027)2.14436292
51Turricephaly (HP:0000262)2.11694734
52Lower limb amyotrophy (HP:0007210)2.10034522
53Cortical dysplasia (HP:0002539)2.09768028
54Selective tooth agenesis (HP:0001592)2.09663211
55Round ear (HP:0100830)2.07736505
56Broad ribs (HP:0000885)2.07584702
57Bradycardia (HP:0001662)2.06837818
58Wide anterior fontanel (HP:0000260)2.01973482
59Congenital glaucoma (HP:0001087)2.01925331
60Disproportionate tall stature (HP:0001519)2.01717180
61Aortic regurgitation (HP:0001659)2.01131226
62Mitral valve prolapse (HP:0001634)2.01019219
63Myokymia (HP:0002411)2.00678189
64Increased variability in muscle fiber diameter (HP:0003557)1.99774126
65Focal seizures (HP:0007359)1.99379122
66Follicular hyperkeratosis (HP:0007502)1.98973165
67Scapular winging (HP:0003691)1.97069272
68Generalized amyotrophy (HP:0003700)1.96946720
69Abnormality of the acetabulum (HP:0003170)1.96292234
70Abnormality of skeletal muscle fiber size (HP:0012084)1.96095648
71Aortic valve stenosis (HP:0001650)1.95926912
72Type 1 muscle fiber predominance (HP:0003803)1.94933178
73Choanal stenosis (HP:0000452)1.94225758
74Pheochromocytoma (HP:0002666)1.94105110
75J-shaped sella turcica (HP:0002680)1.92927340
76Deviation of the hallux (HP:0010051)1.92678538
77Upper limb amyotrophy (HP:0009129)1.91996829
78Distal upper limb amyotrophy (HP:0007149)1.91996829
79Protruding ear (HP:0000411)1.90280342
80Arnold-Chiari malformation (HP:0002308)1.89852961
81Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.89212622
82Degeneration of the lateral corticospinal tracts (HP:0002314)1.89212622
83Insidious onset (HP:0003587)1.88912125
84Termporal pattern (HP:0011008)1.88912125
85Flat cornea (HP:0007720)1.88725961
86Cerebral inclusion bodies (HP:0100314)1.88324275
87Natal tooth (HP:0000695)1.88056119
88Coxa vara (HP:0002812)1.87226166
89Hyperacusis (HP:0010780)1.82388624
90Spinal cord lesions (HP:0100561)1.82365343
91Syringomyelia (HP:0003396)1.82365343
92Deformed tarsal bones (HP:0008119)1.82336502
93Delayed closure of the anterior fontanelle (HP:0001476)1.80316488
94Elbow flexion contracture (HP:0002987)1.80223984
95Nonimmune hydrops fetalis (HP:0001790)1.78440027
96Autoamputation (HP:0001218)1.78174284
97Joint laxity (HP:0001388)1.77587497
98Broad phalanx (HP:0006009)1.77551764
99Calcaneovalgus deformity (HP:0001848)1.77286140
100Hand muscle atrophy (HP:0009130)1.77238707
101Femoral bowing (HP:0002980)1.77193750
102Osteolytic defects of the hand bones (HP:0009699)1.76383189
103Osteolytic defects of the phalanges of the hand (HP:0009771)1.76383189
104Partial duplication of the phalanx of hand (HP:0009999)1.75904198
105Supranuclear gaze palsy (HP:0000605)1.75093560
106Mild short stature (HP:0003502)1.74398981
107Ectopia lentis (HP:0001083)1.74081267
108Camptodactyly of toe (HP:0001836)1.73802970
109Osteoarthritis (HP:0002758)1.73422882
110Morphological abnormality of the middle ear (HP:0008609)1.73341391
111Stridor (HP:0010307)1.72925199
112Narrow nasal bridge (HP:0000446)1.72418823
113Premature skin wrinkling (HP:0100678)1.72240460
114Beaking of vertebral bodies (HP:0004568)1.71960014
115Ankle clonus (HP:0011448)1.71808842
116Delayed cranial suture closure (HP:0000270)1.71681343
117Spondylolisthesis (HP:0003302)1.70749299
118Insomnia (HP:0100785)1.70550443
119Sensory axonal neuropathy (HP:0003390)1.70544781
120Focal motor seizures (HP:0011153)1.70013364
121Breech presentation (HP:0001623)1.69647353
122Tibial bowing (HP:0002982)1.69492963
123Overriding aorta (HP:0002623)1.69475861
124Neuroendocrine neoplasm (HP:0100634)1.69453715
125Hypoventilation (HP:0002791)1.68985521
126Abnormality of the anterior chamber (HP:0000593)1.68624562
127Increased connective tissue (HP:0009025)1.68489892
128Gastrointestinal dysmotility (HP:0002579)1.68472508
129Hallux valgus (HP:0001822)1.67587949
130Achilles tendon contracture (HP:0001771)1.67454352
131Redundant skin (HP:0001582)1.67446358
132Venous abnormality (HP:0002624)1.66988457
133Short hallux (HP:0010109)1.66885433
134Abnormality of glycolysis (HP:0004366)1.66677155
135Increased serum pyruvate (HP:0003542)1.66677155
136Fused cervical vertebrae (HP:0002949)1.66486304
137Abnormality of the umbilical cord (HP:0010881)1.66147872
138Inguinal hernia (HP:0000023)1.65327520
139Broad finger (HP:0001500)1.63815864
140Microglossia (HP:0000171)1.63246747
141Hammertoe (HP:0001765)1.62866278
142Osteopenia (HP:0000938)1.62674883
143Long toe (HP:0010511)1.62659207
144Broad thumb (HP:0011304)1.61615133
145Shoulder girdle muscle weakness (HP:0003547)1.61514082
146Absent frontal sinuses (HP:0002688)1.61294341

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LIMK14.16423233
2DDR23.14947565
3LATS23.13518663
4TESK12.84158110
5CASK2.82818327
6STK392.70424391
7TTK2.47719023
8NTRK12.37148580
9PAK32.35361391
10TSSK62.32926270
11BUB12.32094916
12PAK42.29313659
13PLK22.18986339
14MINK12.07820314
15NTRK32.05095981
16MAPKAPK52.04563788
17TTN2.03043992
18BCR2.02533184
19CDC71.96982616
20ERBB31.90251847
21TESK21.87226876
22LATS11.80377423
23PLK31.79660245
24OXSR11.75686337
25PTK2B1.68645774
26SMG11.67952610
27PDGFRA1.67853999
28FLT31.61917878
29MAP3K101.61251584
30PAK21.59922682
31EPHA31.55933725
32TAF11.53864783
33EPHB11.53360240
34ERBB41.52853768
35TRPM71.49479465
36PIK3CA1.49417369
37CDK141.43286650
38RIPK11.42360713
39MYLK1.40123793
40ARAF1.39610193
41BMX1.38321731
42MARK11.37513188
43PAK61.37259468
44FER1.35781303
45DYRK31.32562258
46PIK3CG1.31802050
47PRPF4B1.29926671
48MET1.28910496
49WNK11.27353674
50CDK181.27212954
51CDK151.25314013
52SRPK11.23840580
53VRK21.21185566
54ROCK21.17960463
55MOS1.14621232
56EPHB21.13903624
57NEK91.12680487
58MKNK11.11162221
59ROCK11.10121438
60CDK11A1.06645944
61MAP3K91.05541134
62STK38L1.05499957
63PTK21.05486838
64EEF2K1.04207203
65PRKD21.03923087
66STK30.99879137
67PRKG20.98940296
68PIM20.97357952
69CDK190.97322886
70TNIK0.94973713
71NEK10.93806146
72WNK40.93321953
73PBK0.92607850
74MKNK20.90733567
75PLK10.90168954
76CHEK20.89697542
77DMPK0.89282255
78PKN10.88764067
79NEK60.88509981
80CAMK2D0.88336598
81UHMK10.88025486
82PRKCE0.87640504
83CAMK1G0.84353739
84CAMK2A0.84350144
85DAPK30.84349756
86CAMK2B0.83752759
87CDC42BPA0.82060827
88MAP3K40.80379578
89NEK20.79954501
90CDK50.79849135
91STK380.79220196
92MAP2K70.78606449
93CSNK1G30.78132139
94PAK10.77581951
95GRK50.76287780
96MAP2K10.75805120
97FGFR20.75598828
98RPS6KA20.73939346
99PNCK0.73902769
100CSNK1G20.71356381
101INSR0.69711374
102TIE10.67677017
103MAP3K80.67592606
104ALK0.67430401
105EIF2AK10.66546765
106KSR20.66371048
107ZAK0.64800793
108MTOR0.64794711
109ABL20.64476751
110STK40.64280276
111TRIM280.63369068
112BRAF0.62131799
113CSNK1A1L0.61889324
114AURKB0.60982203
115PRKCG0.59808782
116PDGFRB0.59489952
117FYN0.58390155
118CDK70.58176638
119AKT30.57824097
120FGR0.57368322
121PRKD10.56999785
122CDK120.56638201
123CAMKK20.56430292
124CAMK2G0.55239738
125FGFR10.54826507
126TGFBR20.54617878
127CAMKK10.54368774
128SRC0.51204249
129BRSK10.51079624
130ADRBK10.50345667
131RET0.48248340
132CHEK10.48216830
133DYRK20.47788094
134AURKA0.47653708
135ILK0.47497598
136PRKD30.47128407
137MAPK130.46698278
138NTRK20.44341547
139MELK0.43791299
140BRSK20.43755421
141RPS6KA40.43321363
142PRKCH0.42209139
143PRKG10.42152574
144KDR0.41848035
145CSNK1G10.40605944
146CAMK1D0.37939976
147GSK3A0.37447968
148CLK10.36375408
149DYRK1B0.36221757
150KSR10.36054392
151FRK0.35171918
152PHKG10.33851767
153PHKG20.33851767
154CSNK1A10.32166520
155BMPR20.31689763
156ICK0.29920274

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.85991377
2ECM-receptor interaction_Homo sapiens_hsa045122.29403088
3Steroid biosynthesis_Homo sapiens_hsa001002.24206475
4Synaptic vesicle cycle_Homo sapiens_hsa047212.22980300
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.14726039
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.11119194
7Vibrio cholerae infection_Homo sapiens_hsa051102.07204207
8Selenocompound metabolism_Homo sapiens_hsa004501.96308638
9Vitamin B6 metabolism_Homo sapiens_hsa007501.90260020
10Focal adhesion_Homo sapiens_hsa045101.85512454
11Dilated cardiomyopathy_Homo sapiens_hsa054141.79660345
12GABAergic synapse_Homo sapiens_hsa047271.76690333
13Biosynthesis of amino acids_Homo sapiens_hsa012301.75708754
14Nicotine addiction_Homo sapiens_hsa050331.74472311
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.74281525
16Axon guidance_Homo sapiens_hsa043601.74068004
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.73638713
18Basal cell carcinoma_Homo sapiens_hsa052171.71856275
19Phagosome_Homo sapiens_hsa041451.71275599
20Serotonergic synapse_Homo sapiens_hsa047261.67874059
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.67030994
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.65999151
23DNA replication_Homo sapiens_hsa030301.63646561
24Central carbon metabolism in cancer_Homo sapiens_hsa052301.62912031
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.58153780
26Fatty acid elongation_Homo sapiens_hsa000621.58112382
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57789871
28Collecting duct acid secretion_Homo sapiens_hsa049661.56216741
29Malaria_Homo sapiens_hsa051441.51497835
30Rheumatoid arthritis_Homo sapiens_hsa053231.50944737
31Cell cycle_Homo sapiens_hsa041101.49748910
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.46673784
33Circadian entrainment_Homo sapiens_hsa047131.43134204
34Wnt signaling pathway_Homo sapiens_hsa043101.41907223
35Glutamatergic synapse_Homo sapiens_hsa047241.39125875
36Regulation of actin cytoskeleton_Homo sapiens_hsa048101.38908678
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38629402
38Mismatch repair_Homo sapiens_hsa034301.36854509
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.36166632
40Gap junction_Homo sapiens_hsa045401.35618430
41Morphine addiction_Homo sapiens_hsa050321.34275457
42Long-term depression_Homo sapiens_hsa047301.34094550
43Dopaminergic synapse_Homo sapiens_hsa047281.30220752
44Vascular smooth muscle contraction_Homo sapiens_hsa042701.28365873
45Protein export_Homo sapiens_hsa030601.25238291
46Non-homologous end-joining_Homo sapiens_hsa034501.24107103
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.23866742
48RNA transport_Homo sapiens_hsa030131.23727302
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.21893189
50Thyroid cancer_Homo sapiens_hsa052161.21825992
51One carbon pool by folate_Homo sapiens_hsa006701.20762393
52Proteoglycans in cancer_Homo sapiens_hsa052051.20080945
53Melanoma_Homo sapiens_hsa052181.19205373
54Ether lipid metabolism_Homo sapiens_hsa005651.18397213
55Cholinergic synapse_Homo sapiens_hsa047251.17226819
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16285050
57Amoebiasis_Homo sapiens_hsa051461.15001233
58Cocaine addiction_Homo sapiens_hsa050301.13762449
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.13196915
60p53 signaling pathway_Homo sapiens_hsa041151.07223831
61Ras signaling pathway_Homo sapiens_hsa040141.06204528
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05672254
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05384160
64Shigellosis_Homo sapiens_hsa051311.04573465
65PI3K-Akt signaling pathway_Homo sapiens_hsa041511.01740200
66SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01095970
67Amphetamine addiction_Homo sapiens_hsa050310.99232604
68Rap1 signaling pathway_Homo sapiens_hsa040150.99091159
69mRNA surveillance pathway_Homo sapiens_hsa030150.98936450
70Hippo signaling pathway_Homo sapiens_hsa043900.98624505
71Glioma_Homo sapiens_hsa052140.98435200
72GnRH signaling pathway_Homo sapiens_hsa049120.97334380
73Oxytocin signaling pathway_Homo sapiens_hsa049210.96985028
74Pathways in cancer_Homo sapiens_hsa052000.96863927
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96508625
76TGF-beta signaling pathway_Homo sapiens_hsa043500.96344721
77Protein digestion and absorption_Homo sapiens_hsa049740.95853113
78Bladder cancer_Homo sapiens_hsa052190.95746289
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95447363
80Oxidative phosphorylation_Homo sapiens_hsa001900.94808698
81Renal cell carcinoma_Homo sapiens_hsa052110.94104717
82Galactose metabolism_Homo sapiens_hsa000520.92162959
83Endocytosis_Homo sapiens_hsa041440.92106285
84ErbB signaling pathway_Homo sapiens_hsa040120.92065757
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91842293
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.90888034
87Olfactory transduction_Homo sapiens_hsa047400.90642642
88Carbon metabolism_Homo sapiens_hsa012000.90455220
89Tight junction_Homo sapiens_hsa045300.90290072
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89778796
91Salivary secretion_Homo sapiens_hsa049700.89062488
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.85681440
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85024414
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84857970
95Nucleotide excision repair_Homo sapiens_hsa034200.84823157
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84760272
97Taste transduction_Homo sapiens_hsa047420.82472845
98Spliceosome_Homo sapiens_hsa030400.82281684
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82231244
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81495932
101Base excision repair_Homo sapiens_hsa034100.81058271
102Cardiac muscle contraction_Homo sapiens_hsa042600.80531736
103Pentose phosphate pathway_Homo sapiens_hsa000300.80525342
104Ovarian steroidogenesis_Homo sapiens_hsa049130.80341857
105Salmonella infection_Homo sapiens_hsa051320.79195255
106Sphingolipid metabolism_Homo sapiens_hsa006000.78917062
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78715920
108Prostate cancer_Homo sapiens_hsa052150.78700106
109Colorectal cancer_Homo sapiens_hsa052100.78498870
110Lysosome_Homo sapiens_hsa041420.78125649
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75957323
112Small cell lung cancer_Homo sapiens_hsa052220.75752701
113MAPK signaling pathway_Homo sapiens_hsa040100.73775583
114Sulfur metabolism_Homo sapiens_hsa009200.73416556
115Gastric acid secretion_Homo sapiens_hsa049710.72545341
116N-Glycan biosynthesis_Homo sapiens_hsa005100.71859192
117Long-term potentiation_Homo sapiens_hsa047200.71535350
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71060016
119Alzheimers disease_Homo sapiens_hsa050100.69263932
120Lysine degradation_Homo sapiens_hsa003100.68772775
121Adherens junction_Homo sapiens_hsa045200.67918867
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67031116
123Parkinsons disease_Homo sapiens_hsa050120.66241293
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66176482
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.63312158
126RNA polymerase_Homo sapiens_hsa030200.63020014
127Oocyte meiosis_Homo sapiens_hsa041140.62792047
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62213812
129Insulin secretion_Homo sapiens_hsa049110.62149536
130Melanogenesis_Homo sapiens_hsa049160.60555284
131Calcium signaling pathway_Homo sapiens_hsa040200.60327300
132MicroRNAs in cancer_Homo sapiens_hsa052060.60157509
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59859605
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59705010
135Platelet activation_Homo sapiens_hsa046110.58385427
136Leukocyte transendothelial migration_Homo sapiens_hsa046700.58296890
137Pyruvate metabolism_Homo sapiens_hsa006200.58260477
138Renin secretion_Homo sapiens_hsa049240.58016640
139Basal transcription factors_Homo sapiens_hsa030220.56685538
140Proteasome_Homo sapiens_hsa030500.56499259
141Thyroid hormone synthesis_Homo sapiens_hsa049180.54667004
142Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54106545
143Estrogen signaling pathway_Homo sapiens_hsa049150.54094313
144Renin-angiotensin system_Homo sapiens_hsa046140.53532861
145Pyrimidine metabolism_Homo sapiens_hsa002400.52405946
146Endometrial cancer_Homo sapiens_hsa052130.50813521
147cAMP signaling pathway_Homo sapiens_hsa040240.48508071
148Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48316403
149Hedgehog signaling pathway_Homo sapiens_hsa043400.47214235
150Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46543118
151Chronic myeloid leukemia_Homo sapiens_hsa052200.46423172
152cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45906897
153Alcoholism_Homo sapiens_hsa050340.42048266
154Glutathione metabolism_Homo sapiens_hsa004800.41364967
155Prion diseases_Homo sapiens_hsa050200.40070804
156Arginine and proline metabolism_Homo sapiens_hsa003300.39864665
157Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39144482
158Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38309724

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