GPR160

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)5.74061859
2angiotensin maturation (GO:0002003)5.73669405
3cilium or flagellum-dependent cell motility (GO:0001539)5.09879910
4multicellular organism reproduction (GO:0032504)4.85961977
5sperm-egg recognition (GO:0035036)4.75350764
6sperm motility (GO:0030317)4.68827035
7cell wall macromolecule catabolic process (GO:0016998)4.59968314
8cell wall macromolecule metabolic process (GO:0044036)4.59968314
9axonemal dynein complex assembly (GO:0070286)4.59089106
10regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.56110233
11cell-cell recognition (GO:0009988)4.36957778
12acrosome assembly (GO:0001675)4.34372170
13piRNA metabolic process (GO:0034587)4.31986068
14binding of sperm to zona pellucida (GO:0007339)4.24427467
15neutrophil mediated immunity (GO:0002446)4.16511295
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.16333147
17positive regulation by organism of defense response of other organism involved in symbiotic interact4.16333147
18modulation by symbiont of host immune response (GO:0052553)4.16333147
19positive regulation by symbiont of host defense response (GO:0052509)4.16333147
20modulation by symbiont of host defense response (GO:0052031)4.16333147
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.16333147
22plasma membrane fusion (GO:0045026)4.13830232
23reproduction (GO:0000003)4.04663417
24interferon-gamma secretion (GO:0072643)3.95243427
25regulation of growth of symbiont in host (GO:0044126)3.91633016
26negative regulation of growth of symbiont in host (GO:0044130)3.91633016
27negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.91633016
28modulation of growth of symbiont involved in interaction with host (GO:0044144)3.91633016
29acrosome reaction (GO:0007340)3.91378781
30leukocyte mediated cytotoxicity (GO:0001909)3.88843380
31regulation of interferon-beta biosynthetic process (GO:0045357)3.80409599
32antibacterial humoral response (GO:0019731)3.78394987
33spermatid development (GO:0007286)3.75350446
34male meiosis (GO:0007140)3.74058929
35DNA deamination (GO:0045006)3.71484624
36antimicrobial humoral response (GO:0019730)3.69472670
37NADH metabolic process (GO:0006734)3.61965744
38motile cilium assembly (GO:0044458)3.56318501
39disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.56153565
40killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.56153565
41regulation of cellular extravasation (GO:0002691)3.54197714
42regulation of guanylate cyclase activity (GO:0031282)3.52340291
43B cell mediated immunity (GO:0019724)3.52138391
44intestinal absorption (GO:0050892)3.51156724
45detection of other organism (GO:0098543)3.49374246
46respiratory burst (GO:0045730)3.48912908
47lipoprotein transport (GO:0042953)3.47949992
48response to peptidoglycan (GO:0032494)3.45027567
49neutrophil activation involved in immune response (GO:0002283)3.41867724
50detection of bacterium (GO:0016045)3.40291798
51maintenance of gastrointestinal epithelium (GO:0030277)3.39220011
52negative regulation of phagocytosis (GO:0050765)3.37046871
53response to fungus (GO:0009620)3.36745697
54positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.35643698
55peptide catabolic process (GO:0043171)3.30507231
56macrophage activation involved in immune response (GO:0002281)3.29033523
57positive regulation of gamma-delta T cell activation (GO:0046645)3.20508250
58defense response to fungus (GO:0050832)3.18392647
59myeloid leukocyte mediated immunity (GO:0002444)3.16721351
60synaptonemal complex assembly (GO:0007130)3.15570578
61regulation of interleukin-8 biosynthetic process (GO:0045414)3.13514692
62positive regulation of Cdc42 GTPase activity (GO:0043089)3.12949961
63regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.12453587
64synaptonemal complex organization (GO:0070193)3.12118754
65epithelial cilium movement (GO:0003351)3.11739817
66regulation of bile acid biosynthetic process (GO:0070857)3.09714527
67epoxygenase P450 pathway (GO:0019373)3.09615491
68antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.07894790
69glycosphingolipid catabolic process (GO:0046479)3.06908893
70single fertilization (GO:0007338)3.06153267
71regulation of necroptotic process (GO:0060544)3.04387391
72antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.01712520
73antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.01712520
74immunoglobulin mediated immune response (GO:0016064)3.01053930
75regulation of vitamin metabolic process (GO:0030656)2.99486523
76glycolipid catabolic process (GO:0019377)2.98818450
77negative regulation of necroptotic process (GO:0060546)2.98722330
78response to host immune response (GO:0052572)2.97559703
79response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.97559703
80reactive oxygen species biosynthetic process (GO:1903409)2.97379788
81leukocyte aggregation (GO:0070486)2.96996791
82neutrophil activation (GO:0042119)2.92317786
83natural killer cell mediated immunity (GO:0002228)2.90549010
84natural killer cell mediated cytotoxicity (GO:0042267)2.90549010
85regulation of cilium movement (GO:0003352)2.90018044
86lipoxygenase pathway (GO:0019372)2.89919383
87fructose metabolic process (GO:0006000)2.89884452
88fat-soluble vitamin biosynthetic process (GO:0042362)2.89840339
89epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.88324218
90transcytosis (GO:0045056)2.87166272
91positive regulation of interferon-alpha production (GO:0032727)2.86010648
92B cell receptor signaling pathway (GO:0050853)2.85318356
93chromosome organization involved in meiosis (GO:0070192)2.81831280
94negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.81078210
95negative regulation of cell killing (GO:0031342)2.81078210
96regulation of chemokine secretion (GO:0090196)2.80553873
97leukotriene metabolic process (GO:0006691)2.78238266
98antigen processing and presentation of endogenous antigen (GO:0019883)2.77641737
99negative regulation of interleukin-8 production (GO:0032717)2.76707350
100detection of external biotic stimulus (GO:0098581)2.76223845
101cellular glucuronidation (GO:0052695)2.75665472
102granulocyte activation (GO:0036230)2.75498107
103urea cycle (GO:0000050)2.75455281
104cell killing (GO:0001906)2.75406663
105intestinal epithelial cell development (GO:0060576)2.74598216
106meiotic cell cycle (GO:0051321)2.72699513
107uronic acid metabolic process (GO:0006063)2.72057605
108glucuronate metabolic process (GO:0019585)2.72057605
109response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.71583813
110response to host (GO:0075136)2.71583813
111response to host defenses (GO:0052200)2.71583813
112DNA methylation involved in gamete generation (GO:0043046)2.70777115
113killing of cells of other organism (GO:0031640)2.69838716
114disruption of cells of other organism (GO:0044364)2.69838716
115hormone catabolic process (GO:0042447)2.69649891
116organic cation transport (GO:0015695)2.68587778
117negative regulation of chemokine production (GO:0032682)2.68085408
118regulation of interferon-alpha production (GO:0032647)2.65328208
119protein localization to chromosome, centromeric region (GO:0071459)2.62024823
120regulation of gamma-delta T cell activation (GO:0046643)2.61732039
121citrulline biosynthetic process (GO:0019240)2.61479280
122meiotic nuclear division (GO:0007126)2.60768334
123positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.59938622
124organ or tissue specific immune response (GO:0002251)2.58983008
125embryonic process involved in female pregnancy (GO:0060136)2.58517323
126Arp2/3 complex-mediated actin nucleation (GO:0034314)2.57692407
127positive regulation of B cell differentiation (GO:0045579)2.57652561
128innate immune response in mucosa (GO:0002227)2.57621885
129ribosomal small subunit assembly (GO:0000028)2.57474138
130dendritic cell chemotaxis (GO:0002407)2.57451340
131positive regulation of mast cell activation (GO:0033005)2.56172335
132leukotriene biosynthetic process (GO:0019370)2.55370412
133male meiosis I (GO:0007141)2.55229090
134interferon-gamma-mediated signaling pathway (GO:0060333)2.55202736
135gonadal mesoderm development (GO:0007506)2.55122449
136epithelial structure maintenance (GO:0010669)2.54663584
137regulation of systemic arterial blood pressure by hormone (GO:0001990)2.53317059
138regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.53317059
139endocrine process (GO:0050886)2.53317059
140positive regulation of guanylate cyclase activity (GO:0031284)2.52653636
141rRNA catabolic process (GO:0016075)2.51379797
142regulation of necrotic cell death (GO:0010939)2.50565251
143urea metabolic process (GO:0019627)2.50418533
144fertilization (GO:0009566)2.49433128
145cellular response to zinc ion (GO:0071294)2.49352428
146hepatocyte apoptotic process (GO:0097284)2.49036708
147mucosal immune response (GO:0002385)2.48700414
148homocysteine metabolic process (GO:0050667)2.48680688
149sequestering of actin monomers (GO:0042989)2.47500574
150sphingomyelin metabolic process (GO:0006684)2.46608592
151telomere maintenance via semi-conservative replication (GO:0032201)2.46301219
152regulation of superoxide anion generation (GO:0032928)2.45733001
153nucleoside diphosphate biosynthetic process (GO:0009133)2.45312366
154plasma lipoprotein particle assembly (GO:0034377)2.44706204
155response to muramyl dipeptide (GO:0032495)2.43573966
156sperm capacitation (GO:0048240)2.42441767
157response to hydroperoxide (GO:0033194)2.42234512
158regulation of B cell receptor signaling pathway (GO:0050855)2.42191899
159regulation of triglyceride catabolic process (GO:0010896)2.41131805
160receptor guanylyl cyclase signaling pathway (GO:0007168)2.41094417
161regulation of dendritic cell antigen processing and presentation (GO:0002604)2.39780335
162very-low-density lipoprotein particle assembly (GO:0034379)2.38966418
163ceramide catabolic process (GO:0046514)2.38953827
164cilium movement (GO:0003341)2.38534118
165antigen processing and presentation via MHC class Ib (GO:0002475)2.37866554
166positive regulation of toll-like receptor signaling pathway (GO:0034123)2.37651565
167T-helper 1 type immune response (GO:0042088)2.37469196
168diacylglycerol metabolic process (GO:0046339)2.36260508
169myeloid cell activation involved in immune response (GO:0002275)2.35477610
170negative regulation of granulocyte differentiation (GO:0030853)2.35353340
171leukocyte migration involved in inflammatory response (GO:0002523)2.34742898
172regulation of chemokine biosynthetic process (GO:0045073)2.34552497
173spermatogenesis (GO:0007283)2.34523373
174male gamete generation (GO:0048232)2.33925433
175cellular extravasation (GO:0045123)2.33891226
176positive regulation of cellular amine metabolic process (GO:0033240)2.33817628
177detection of molecule of bacterial origin (GO:0032490)2.33760196
178telomere maintenance via recombination (GO:0000722)2.32780362
179regulation of mast cell activation (GO:0033003)2.32322418
180positive regulation of protein import into nucleus, translocation (GO:0033160)2.32276505
181DNA packaging (GO:0006323)2.30727284
182chromosome condensation (GO:0030261)2.29367684

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.77898743
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.95842858
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.55429562
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.17669823
5* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.17176728
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.87991116
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.78237995
8CDX2_20551321_ChIP-Seq_CACO-2_Human2.48461569
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.47965496
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.43007928
11* IRF8_27001747_Chip-Seq_BMDM_Mouse2.41073315
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.22996400
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.20289060
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.14555092
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.14133826
16* SPI1_23547873_ChIP-Seq_NB4_Human2.11845216
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.11110700
18SOX2_27498859_Chip-Seq_STOMACH_Mouse2.10770510
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.10509324
20* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.09177862
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07286873
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.04434377
23MYC_22102868_ChIP-Seq_BL_Human2.03969788
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99955851
25BRD4_27068464_Chip-Seq_AML-cells_Mouse1.97637165
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93085824
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.93023023
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.90633706
29GATA6_25053715_ChIP-Seq_YYC3_Human1.88596354
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.88465516
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.87581814
32STAT4_19710469_ChIP-ChIP_TH1__Mouse1.85579920
33AR_21909140_ChIP-Seq_LNCAP_Human1.85180744
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.80355029
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78398645
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.76189487
37VDR_21846776_ChIP-Seq_THP-1_Human1.68080311
38* MYB_26560356_Chip-Seq_TH2_Human1.67093705
39PPARA_22158963_ChIP-Seq_LIVER_Mouse1.66375682
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.65856525
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.65694046
42GATA4_25053715_ChIP-Seq_YYC3_Human1.65606499
43LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.64737655
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61236970
45PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.58561365
46FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.58534552
47MYB_26560356_Chip-Seq_TH1_Human1.56950643
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.56090279
49RXR_22158963_ChIP-Seq_LIVER_Mouse1.56054265
50SCL_19346495_ChIP-Seq_HPC-7_Human1.54341124
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.53061919
52CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51541235
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46204922
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46110155
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46017397
56* VDR_24763502_ChIP-Seq_THP-1_Human1.42957610
57PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41755720
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.40254721
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39602431
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.39471320
61PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.39263592
62SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39182948
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.38844567
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.38470705
65TP63_17297297_ChIP-ChIP_HaCaT_Human1.36902113
66Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36366917
67FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.35612215
68TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.34577250
69CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34532858
70EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.34314990
71LXR_22158963_ChIP-Seq_LIVER_Mouse1.34047318
72KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.32144590
73MYC_18358816_ChIP-ChIP_MESCs_Mouse1.27873293
74PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.26704307
75FOXO3_23340844_ChIP-Seq_DLD1_Human1.26023238
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25418580
77* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25316586
78FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.24438834
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24070262
80SPI1_23127762_ChIP-Seq_K562_Human1.22818708
81CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22556725
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22498233
83MAF_26560356_Chip-Seq_TH1_Human1.22414660
84* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21804969
85CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21434748
86MYC_18555785_ChIP-Seq_MESCs_Mouse1.21079201
87PU_27001747_Chip-Seq_BMDM_Mouse1.20459552
88KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19797905
89KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19797905
90KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19797905
91JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.19161982
92GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18652120
93EST1_17652178_ChIP-ChIP_JURKAT_Human1.15371516
94HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15199058
95ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14947067
96GABP_17652178_ChIP-ChIP_JURKAT_Human1.14641155
97VDR_23849224_ChIP-Seq_CD4+_Human1.14329922
98PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13929967
99KAP1_22055183_ChIP-Seq_ESCs_Mouse1.11924017
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11857639
101VDR_24787735_ChIP-Seq_THP-1_Human1.10516673
102* SOX2_20726797_ChIP-Seq_SW620_Human1.10484663
103YY1_21170310_ChIP-Seq_MESCs_Mouse1.10121290
104NOTCH1_21737748_ChIP-Seq_TLL_Human1.10089717
105ELF5_23300383_ChIP-Seq_T47D_Human1.09907604
106KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09742066
107TFEB_21752829_ChIP-Seq_HELA_Human1.09719630
108FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.09311595
109TCF7_22412390_ChIP-Seq_EML_Mouse1.08739263
110RACK7_27058665_Chip-Seq_MCF-7_Human1.07959374
111ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07582983
112FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06789135
113FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.05752801
114AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05521647
115GATA3_26560356_Chip-Seq_TH2_Human1.05197911
116SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04092711
117PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04090155
118BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02259379
119SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01801520
120NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99703287
121STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99660809
122UTX_26944678_Chip-Seq_JUKART_Human0.98410048
123GATA3_24758297_ChIP-Seq_MCF-7_Human0.98315994
124RUNX1_27514584_Chip-Seq_MCF-7_Human0.95647906
125GATA3_27048872_Chip-Seq_THYMUS_Human0.94365977
126SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.93920236
127MYC_19079543_ChIP-ChIP_MESCs_Mouse0.93869612
128CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93852627
129ESR1_21235772_ChIP-Seq_MCF-7_Human0.92779430
130FOXP3_21729870_ChIP-Seq_TREG_Human0.92530515
131MYC_19030024_ChIP-ChIP_MESCs_Mouse0.92362326
132MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91969678
133ESR2_21235772_ChIP-Seq_MCF-7_Human0.90508134
134E2F1_21310950_ChIP-Seq_MCF-7_Human0.90288023
135* CTCF_26484167_Chip-Seq_Bcells_Mouse0.90126757
136GATA1_22025678_ChIP-Seq_K562_Human0.89755460
137FOXA1_25552417_ChIP-Seq_VCAP_Human0.89599794
138SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89476488
139SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.89393874
140GATA3_21867929_ChIP-Seq_CD8_Mouse0.89344656
141CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88564620
142CHD1_26751641_Chip-Seq_LNCaP_Human0.88325413
143ETS1_22383799_ChIP-Seq_G1ME_Mouse0.88156212
144SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.87815960
145NELFA_20434984_ChIP-Seq_ESCs_Mouse0.85963481
146RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.84649907
147* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84327347
148MAF_26560356_Chip-Seq_TH2_Human0.83948851
149LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.83589288
150SPI1_20517297_ChIP-Seq_HL60_Human0.82839765
151STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.82589367

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.63535214
2MP0005360_urolithiasis4.21713432
3MP0001835_abnormal_antigen_presentation3.20615624
4MP0010234_abnormal_vibrissa_follicle3.06849799
5MP0003436_decreased_susceptibility_to3.01362406
6MP0002139_abnormal_hepatobiliary_system2.97664317
7MP0009785_altered_susceptibility_to2.86024988
8MP0001666_abnormal_nutrient_absorption2.73015720
9MP0002148_abnormal_hypersensitivity_rea2.72782252
10MP0003724_increased_susceptibility_to2.56482763
11MP0005085_abnormal_gallbladder_physiolo2.54264062
12MP0008057_abnormal_DNA_replication2.50227225
13MP0003693_abnormal_embryo_hatching2.42212771
14MP0005025_abnormal_response_to2.38254745
15MP0002419_abnormal_innate_immunity2.35717481
16MP0002396_abnormal_hematopoietic_system2.25243762
17MP0005000_abnormal_immune_tolerance2.12396591
18MP0005671_abnormal_response_to2.10978477
19MP0002009_preneoplasia2.05660527
20MP0010094_abnormal_chromosome_stability1.98429147
21MP0002452_abnormal_antigen_presenting1.96382601
22MP0001800_abnormal_humoral_immune1.95172440
23MP0002166_altered_tumor_susceptibility1.94635208
24MP0002006_tumorigenesis1.94165888
25MP0005365_abnormal_bile_salt1.94153017
26MP0005451_abnormal_body_composition1.93771103
27MP0001819_abnormal_immune_cell1.89498406
28MP0002420_abnormal_adaptive_immunity1.88802496
29MP0002723_abnormal_immune_serum1.85873399
30MP0003763_abnormal_thymus_physiology1.83568235
31MP0010155_abnormal_intestine_physiology1.82011415
32MP0001929_abnormal_gametogenesis1.81993102
33MP0002405_respiratory_system_inflammati1.81620400
34MP0003183_abnormal_peptide_metabolism1.80911587
35MP0005174_abnormal_tail_pigmentation1.80181969
36MP0004019_abnormal_vitamin_homeostasis1.76109533
37MP0001853_heart_inflammation1.73777909
38MP0000490_abnormal_crypts_of1.72735520
39MP0004264_abnormal_extraembryonic_tissu1.71763679
40MP0003806_abnormal_nucleotide_metabolis1.69850700
41MP0008877_abnormal_DNA_methylation1.69130362
42MP0001790_abnormal_immune_system1.66497001
43MP0005387_immune_system_phenotype1.66497001
44MP0003111_abnormal_nucleus_morphology1.63055576
45MP0008058_abnormal_DNA_repair1.62467279
46MP0003698_abnormal_male_reproductive1.62370408
47MP0005464_abnormal_platelet_physiology1.62223928
48MP0009333_abnormal_splenocyte_physiolog1.61219059
49MP0000858_altered_metastatic_potential1.60208199
50MP0001545_abnormal_hematopoietic_system1.60096553
51MP0005397_hematopoietic_system_phenotyp1.60096553
52MP0003866_abnormal_defecation1.58610467
53MP0004147_increased_porphyrin_level1.54930061
54MP0005075_abnormal_melanosome_morpholog1.54519125
55MP0001845_abnormal_inflammatory_respons1.54308464
56MP0001873_stomach_inflammation1.54068585
57MP0002398_abnormal_bone_marrow1.51754889
58MP0003303_peritoneal_inflammation1.50465395
59MP0000685_abnormal_immune_system1.48568859
60MP0000716_abnormal_immune_system1.46069218
61MP0002796_impaired_skin_barrier1.43455622
62MP0008260_abnormal_autophagy1.42835438
63MP0003077_abnormal_cell_cycle1.42695295
64MP0000465_gastrointestinal_hemorrhage1.41172887
65MP0003300_gastrointestinal_ulcer1.38860250
66MP0006082_CNS_inflammation1.36959726
67MP0004947_skin_inflammation1.36945080
68MP0001533_abnormal_skeleton_physiology1.36881454
69MP0000689_abnormal_spleen_morphology1.32976764
70MP0003252_abnormal_bile_duct1.31483429
71MP0002722_abnormal_immune_system1.30073922
72MP0004808_abnormal_hematopoietic_stem1.29568517
73MP0002429_abnormal_blood_cell1.28589993
74MP0002138_abnormal_hepatobiliary_system1.26720279
75MP0004957_abnormal_blastocyst_morpholog1.26237330
76MP0002210_abnormal_sex_determination1.25752115
77MP0008007_abnormal_cellular_replicative1.24288680
78MP0010307_abnormal_tumor_latency1.22355121
79MP0004381_abnormal_hair_follicle1.22046384
80MP0009643_abnormal_urine_homeostasis1.21746928
81MP0001765_abnormal_ion_homeostasis1.20469342
82MP0005501_abnormal_skin_physiology1.17316577
83MP0009379_abnormal_foot_pigmentation1.16935867
84MP0008469_abnormal_protein_level1.16867790
85MP0005058_abnormal_lysosome_morphology1.16466261
86MP0005166_decreased_susceptibility_to1.13636151
87MP0001664_abnormal_digestion1.13328375
88MP0003868_abnormal_feces_composition1.13287042
89MP0001851_eye_inflammation1.13075561
90MP0000343_altered_response_to1.12941441
91MP0003448_altered_tumor_morphology1.12925763
92MP0005332_abnormal_amino_acid1.12848027
93MP0000477_abnormal_intestine_morphology1.12540370
94MP0001145_abnormal_male_reproductive1.12233043
95MP0000678_abnormal_parathyroid_gland1.11278078
96MP0006054_spinal_hemorrhage1.10217615
97MP0002254_reproductive_system_inflammat1.10092705
98MP0002277_abnormal_respiratory_mucosa1.08223604
99MP0003172_abnormal_lysosome_physiology1.06904800
100MP0001663_abnormal_digestive_system1.06719669
101MP0003718_maternal_effect1.06336626
102MP0005636_abnormal_mineral_homeostasis1.05346957
103MP0002019_abnormal_tumor_incidence1.05286372
104MP0000609_abnormal_liver_physiology1.05141948
105MP0009840_abnormal_foam_cell1.02643894
106MP0001216_abnormal_epidermal_layer1.01743650
107MP0003566_abnormal_cell_adhesion0.98942430
108MP0003191_abnormal_cellular_cholesterol0.98758898
109MP0004782_abnormal_surfactant_physiolog0.97424064
110MP0002136_abnormal_kidney_physiology0.96755318
111MP0005310_abnormal_salivary_gland0.96530577
112MP0010329_abnormal_lipoprotein_level0.95880615
113MP0004185_abnormal_adipocyte_glucose0.93667693
114MP0000015_abnormal_ear_pigmentation0.92731036
115MP0000653_abnormal_sex_gland0.92667628
116MP0005319_abnormal_enzyme/_coenzyme0.92613114
117MP0000703_abnormal_thymus_morphology0.91685986
118MP0009764_decreased_sensitivity_to0.89661685
119MP0005076_abnormal_cell_differentiation0.88290289
120MP0005666_abnormal_adipose_tissue0.87517156
121MP0002132_abnormal_respiratory_system0.84547793
122MP0001764_abnormal_homeostasis0.83977081
123MP0002161_abnormal_fertility/fecundity0.83731263
124MP0010352_gastrointestinal_tract_polyps0.83378565
125MP0003186_abnormal_redox_activity0.82004218
126MP0008004_abnormal_stomach_pH0.81593174
127MP0009115_abnormal_fat_cell0.79741894
128MP0009278_abnormal_bone_marrow0.78561442
129MP0002095_abnormal_skin_pigmentation0.78201126
130MP0003786_premature_aging0.77442229
131MP0002098_abnormal_vibrissa_morphology0.76454880
132MP0002160_abnormal_reproductive_system0.76149071
133MP0002118_abnormal_lipid_homeostasis0.75277311
134MP0001881_abnormal_mammary_gland0.75188931
135MP0000313_abnormal_cell_death0.74311246
136MP0003453_abnormal_keratinocyte_physiol0.72477425
137MP0005670_abnormal_white_adipose0.71665521

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.49865002
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.92876326
3Absent/shortened dynein arms (HP:0200106)5.92876326
4Recurrent abscess formation (HP:0002722)4.93683546
5Abnormality of glutamine family amino acid metabolism (HP:0010902)4.61143084
6Recurrent bacterial skin infections (HP:0005406)4.56482455
7Nasal polyposis (HP:0100582)4.49721652
8Abnormal respiratory motile cilium morphology (HP:0005938)4.27219043
9Abnormal respiratory epithelium morphology (HP:0012253)4.27219043
10Eczematoid dermatitis (HP:0000976)4.20120542
11Malnutrition (HP:0004395)4.13098099
12Abnormal respiratory motile cilium physiology (HP:0012261)4.05085127
13Abnormality of the nasal mucosa (HP:0000433)3.82896051
14Thrombocytosis (HP:0001894)3.53093702
15Hyperactive renin-angiotensin system (HP:0000841)3.48523448
16Rhinitis (HP:0012384)3.45432427
17Myositis (HP:0100614)3.41375435
18Chronic obstructive pulmonary disease (HP:0006510)3.29506137
19Obstructive lung disease (HP:0006536)3.29506137
20Chronic bronchitis (HP:0004469)3.28038223
21Reticulocytopenia (HP:0001896)3.22161731
22Recurrent gram-negative bacterial infections (HP:0005420)3.10461963
23Elevated erythrocyte sedimentation rate (HP:0003565)3.07880891
24Bronchitis (HP:0012387)3.03140100
25Hydroxyprolinuria (HP:0003080)3.01638732
26Abnormality of proline metabolism (HP:0010907)3.01638732
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.99464347
28Abnormality of the vitamin B12 metabolism (HP:0004341)2.99391731
29Bronchiectasis (HP:0002110)2.98867358
30Recurrent sinusitis (HP:0011108)2.97190381
31Abnormal ciliary motility (HP:0012262)2.97086877
32Chromsome breakage (HP:0040012)2.96556697
33Abnormality of the prostate (HP:0008775)2.91462552
34Periodontitis (HP:0000704)2.88732246
35Mediastinal lymphadenopathy (HP:0100721)2.88232996
36Chronic otitis media (HP:0000389)2.87863424
37Recurrent bronchitis (HP:0002837)2.86541351
38Petechiae (HP:0000967)2.83423461
39Abnormality of macrophages (HP:0004311)2.79264898
40Widely patent fontanelles and sutures (HP:0004492)2.79155199
41Fat malabsorption (HP:0002630)2.74358045
42Reduced antithrombin III activity (HP:0001976)2.74007223
43Decreased circulating renin level (HP:0003351)2.73956636
44Colitis (HP:0002583)2.73163362
45Abnormality of vitamin B metabolism (HP:0004340)2.72140914
46Orchitis (HP:0100796)2.65696051
47Flat acetabular roof (HP:0003180)2.63924108
48Ileus (HP:0002595)2.63206230
49Acanthocytosis (HP:0001927)2.63025673
50Recurrent fungal infections (HP:0002841)2.58710416
51Recurrent skin infections (HP:0001581)2.58708177
52Vacuolated lymphocytes (HP:0001922)2.57294325
53Abnormal spermatogenesis (HP:0008669)2.56177360
54Abnormality of small intestinal villus morphology (HP:0011472)2.55738138
55Villous atrophy (HP:0011473)2.55738138
56Hypobetalipoproteinemia (HP:0003563)2.54702067
57Inflammation of the large intestine (HP:0002037)2.52984348
58Abnormal delayed hypersensitivity skin test (HP:0002963)2.52642678
59IgM deficiency (HP:0002850)2.50362744
60Infertility (HP:0000789)2.49476718
61Pustule (HP:0200039)2.48347389
62Gastrointestinal stroma tumor (HP:0100723)2.48184417
63Abnormality of monocarboxylic acid metabolism (HP:0010996)2.47590409
64Gastrointestinal infarctions (HP:0005244)2.45649587
65Gastrointestinal inflammation (HP:0004386)2.45218464
66Osteomyelitis (HP:0002754)2.43943864
67Hyperglycinuria (HP:0003108)2.43693187
68Abnormality of T cell physiology (HP:0011840)2.41862677
69Gangrene (HP:0100758)2.41090693
70Metabolic alkalosis (HP:0200114)2.40295680
71Recurrent otitis media (HP:0000403)2.39612493
72Eosinophilia (HP:0001880)2.39029173
73Type I transferrin isoform profile (HP:0003642)2.38913342
74Nausea (HP:0002018)2.38546773
75Abnormality of eosinophils (HP:0001879)2.38508071
76Abnormality of the preputium (HP:0100587)2.37585436
77Abnormality of chromosome stability (HP:0003220)2.37025818
78Gingivitis (HP:0000230)2.35326503
79Meningitis (HP:0001287)2.33863798
80Abnormality of renin-angiotensin system (HP:0000847)2.30744947
81Retrobulbar optic neuritis (HP:0100654)2.29387506
82Optic neuritis (HP:0100653)2.29387506
83Recurrent viral infections (HP:0004429)2.29064928
84Urticaria (HP:0001025)2.28854583
85Autoimmune thrombocytopenia (HP:0001973)2.27597784
86Encephalitis (HP:0002383)2.27326092
87Leukocytosis (HP:0001974)2.26169607
88Megaloblastic anemia (HP:0001889)2.24407163
89Hypergammaglobulinemia (HP:0010702)2.23887577
90Agammaglobulinemia (HP:0004432)2.23440304
91Abdominal distention (HP:0003270)2.18954278
92Azoospermia (HP:0000027)2.18060226
93Granulocytopenia (HP:0001913)2.17799865
94Abnormal protein glycosylation (HP:0012346)2.17291144
95Abnormal glycosylation (HP:0012345)2.17291144
96Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.17291144
97Abnormal protein N-linked glycosylation (HP:0012347)2.17291144
98Pigmentary retinal degeneration (HP:0001146)2.17152033
99Abnormality of vitamin metabolism (HP:0100508)2.15729398
100Abnormal tarsal ossification (HP:0008369)2.14935518
101Abnormality of the anterior horn cell (HP:0006802)2.13172745
102Degeneration of anterior horn cells (HP:0002398)2.13172745
103Abnormality of aspartate family amino acid metabolism (HP:0010899)2.12402696
104Abnormality of cells of the erythroid lineage (HP:0012130)2.12121776
105Abnormal number of erythroid precursors (HP:0012131)2.11629647
106Duplicated collecting system (HP:0000081)2.10423937
107Cellulitis (HP:0100658)2.10211749
108Clubbing of toes (HP:0100760)2.09184898
109Vasculitis (HP:0002633)2.09056133
110Increased IgE level (HP:0003212)2.06847102
111Abnormality of DNA repair (HP:0003254)2.06829527
112Abnormality of T cells (HP:0002843)2.05768318
113Abnormality of serine family amino acid metabolism (HP:0010894)2.05483819
114Abnormality of glycine metabolism (HP:0010895)2.05483819
115Combined immunodeficiency (HP:0005387)2.04846450
116Abnormality of chloride homeostasis (HP:0011422)2.04571947
117Autoimmune hemolytic anemia (HP:0001890)2.03745272
118Proximal tubulopathy (HP:0000114)2.00545775
119IgA deficiency (HP:0002720)2.00345464
120Hypophosphatemia (HP:0002148)2.00272835
121Hyperammonemia (HP:0001987)1.98994785
122Anorexia (HP:0002039)1.98864603
123Alkalosis (HP:0001948)1.97989260
124Severe combined immunodeficiency (HP:0004430)1.97544096
125Increased neuronal autofluorescent lipopigment (HP:0002074)1.97019808
126Aplasia/Hypoplasia of the uvula (HP:0010293)1.96463630
127Recurrent pneumonia (HP:0006532)1.96050405
128Gout (HP:0001997)1.96013670
129Premature loss of primary teeth (HP:0006323)1.96005330
130Pulmonary fibrosis (HP:0002206)1.94051644
131Pulmonary infiltrates (HP:0002113)1.92702561
132Increased cerebral lipofuscin (HP:0011813)1.91964559
133Abnormality of B cell number (HP:0010975)1.91847670
134B lymphocytopenia (HP:0010976)1.91847670
135Nonimmune hydrops fetalis (HP:0001790)1.91840098
136Symptomatic seizures (HP:0011145)1.89686669
137Skin rash (HP:0000988)1.89610228
138Sepsis (HP:0100806)1.89492845
139Hemorrhage of the eye (HP:0011885)1.88190295
140Thyroiditis (HP:0100646)1.88094366
141Prostate neoplasm (HP:0100787)1.87776163
142Meckel diverticulum (HP:0002245)1.87470515
143Abnormality of cells of the lymphoid lineage (HP:0012140)1.87116651
144Loss of speech (HP:0002371)1.86832547
145Lymphopenia (HP:0001888)1.86430320
146Curly hair (HP:0002212)1.86076105
147Bone marrow hypocellularity (HP:0005528)1.85937910
148Abnormality of urine glucose concentration (HP:0011016)1.85862716
149Glycosuria (HP:0003076)1.85862716
150Intrahepatic cholestasis (HP:0001406)1.84320045
151Abnormality of the ileum (HP:0001549)1.83435944
152Abnormality of the pleura (HP:0002103)1.82812583
153Systemic lupus erythematosus (HP:0002725)1.82598176
154Impulsivity (HP:0100710)1.82241404
155Abnormal foot bone ossification (HP:0010675)1.82099355
156Keratoconjunctivitis sicca (HP:0001097)1.81855568
157Steatorrhea (HP:0002570)1.81366527
158Ectopic kidney (HP:0000086)1.80796492
159Spontaneous hematomas (HP:0007420)1.80766760
160Abnormality of male internal genitalia (HP:0000022)1.80444681
161Congenital ichthyosiform erythroderma (HP:0007431)1.79515996
162Stomatitis (HP:0010280)1.79110346
163Chronic diarrhea (HP:0002028)1.78475323
164Skin ulcer (HP:0200042)1.77975350
165Abnormality of pyrimidine metabolism (HP:0004353)1.77856735
166Pancreatitis (HP:0001733)1.77373809
167Wide cranial sutures (HP:0010537)1.77248873
168Posterior subcapsular cataract (HP:0007787)1.77080397
169Biliary tract neoplasm (HP:0100574)1.76958326
170Recurrent cutaneous fungal infections (HP:0011370)1.76041124
171Chronic mucocutaneous candidiasis (HP:0002728)1.76041124

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK33.43441118
2PDK43.43441118
3BLK3.39598737
4TESK13.35929039
5IRAK42.98469539
6MST42.90193625
7TEC2.84218303
8MAP3K102.63270221
9PDK22.62955882
10PIM22.61701950
11MAP4K12.33350800
12IRAK32.28379745
13MAP3K142.26658221
14TYK22.15099671
15EPHA22.01232947
16STK161.95930253
17STK241.91835699
18WEE11.89396116
19BUB11.82408406
20PRPF4B1.79105267
21RIPK11.73016729
22OXSR11.70061002
23BMPR21.64962405
24TXK1.61417929
25RIPK41.61325099
26BRSK21.48708187
27KDR1.45331068
28EIF2AK31.44273889
29NEK21.40261765
30TGFBR21.39157529
31CLK11.36615943
32STK101.35780775
33ZAP701.33387900
34SMG11.32159583
35PRKG21.27272950
36BTK1.26859805
37IKBKE1.24955258
38VRK11.22341243
39TBK11.22022731
40TAOK31.21039326
41MAP3K21.20215704
42PIM11.17701612
43TRIB31.14847921
44ERN11.14647754
45EIF2AK21.14245356
46STK391.14067823
47MAP3K121.12854708
48MAPKAPK31.12058295
49TTK1.11233707
50IKBKB1.11061032
51MAP3K11.10021695
52KIT1.07676884
53MAP2K31.06591083
54FGFR41.05310527
55JAK11.02750651
56FGR1.01263702
57TIE11.00088149
58CSF1R0.99653094
59IRAK20.98481487
60IRAK10.95612532
61CDK190.94529132
62MST1R0.94297708
63SYK0.93923930
64TNK20.90562963
65PKN20.90063996
66CSK0.88792300
67ATR0.86841230
68NUAK10.86810977
69PIK3CA0.86670339
70JAK30.84942954
71MAP3K130.83828457
72PBK0.83158302
73SCYL20.82646700
74SIK30.82361126
75TESK20.80873013
76ITK0.80431709
77CHUK0.77552537
78STK38L0.77417945
79LYN0.76480663
80KSR20.73778691
81STK40.73039092
82RPS6KB20.72786577
83CDK40.71809208
84MAP3K80.71475296
85PTK60.71053641
86EEF2K0.70712953
87LRRK20.70533332
88CDC70.70509920
89PLK40.70453548
90PAK40.70386852
91ACVR1B0.70183871
92TRPM70.69145279
93PDPK10.69072021
94NLK0.67373496
95RAF10.66887035
96MATK0.66618929
97NEK10.64919691
98CDK60.64866218
99MAP3K60.64014059
100MAPK150.63200040
101YES10.62696904
102TAOK20.61796675
103FLT30.60582216
104DMPK0.59513358
105RPS6KA40.59117440
106TNIK0.58556502
107CHEK20.58523192
108PRKCI0.58286155
109NME20.57432771
110PLK10.56825886
111SRPK10.56738516
112GRK70.56468457
113CDK70.55806012
114BRSK10.55309840
115HCK0.55228637
116LCK0.54419691
117MAP2K60.53445151
118ZAK0.52806119
119NEK60.51870521
120GRK10.51594721
121CCNB10.51105468
122PIK3CG0.51034809
123GRK60.51002414
124MAP3K30.50783151
125MAP2K20.49862242
126BRAF0.48277637
127PDK10.48133073
128FGFR30.48061064
129ERBB30.48044427
130AURKB0.47399628
131MAP3K50.47212437
132EIF2AK10.47097254
133DYRK30.46747072
134ICK0.46684637
135EPHB10.45608642
136AKT30.45598812
137MAP3K110.45520194
138JAK20.45389102
139ALK0.44360238
140PRKCD0.43163171
141PASK0.42525932
142TAOK10.42504318
143STK380.42491407
144STK30.38688435
145MAPKAPK20.36086596
146MELK0.33585394
147FES0.32975882
148PRKCQ0.31211807

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.56454772
2DNA replication_Homo sapiens_hsa030303.07348410
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.60893804
4Homologous recombination_Homo sapiens_hsa034402.31095563
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.30014103
6Leishmaniasis_Homo sapiens_hsa051402.27935783
7Antigen processing and presentation_Homo sapiens_hsa046122.18224134
8Mismatch repair_Homo sapiens_hsa034302.13803695
9Intestinal immune network for IgA production_Homo sapiens_hsa046721.99107074
10Base excision repair_Homo sapiens_hsa034101.98954309
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.94876425
12Fanconi anemia pathway_Homo sapiens_hsa034601.93145955
13Legionellosis_Homo sapiens_hsa051341.89340180
14Other glycan degradation_Homo sapiens_hsa005111.88271988
15Sulfur metabolism_Homo sapiens_hsa009201.86269233
16Primary immunodeficiency_Homo sapiens_hsa053401.79879632
17Staphylococcus aureus infection_Homo sapiens_hsa051501.79039368
18Non-homologous end-joining_Homo sapiens_hsa034501.76273306
19Pentose phosphate pathway_Homo sapiens_hsa000301.73871572
20Starch and sucrose metabolism_Homo sapiens_hsa005001.72247170
21Ribosome_Homo sapiens_hsa030101.70239022
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.63525230
23Type I diabetes mellitus_Homo sapiens_hsa049401.60868241
24Graft-versus-host disease_Homo sapiens_hsa053321.57948403
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.55031058
26Renin-angiotensin system_Homo sapiens_hsa046141.52252461
27Measles_Homo sapiens_hsa051621.51826954
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.51574488
29Vitamin B6 metabolism_Homo sapiens_hsa007501.50341309
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.49094459
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.45850775
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.43924039
33Arachidonic acid metabolism_Homo sapiens_hsa005901.41335279
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37344133
35Osteoclast differentiation_Homo sapiens_hsa043801.35690575
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.32654130
37Herpes simplex infection_Homo sapiens_hsa051681.32418743
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.32171125
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26665528
40p53 signaling pathway_Homo sapiens_hsa041151.22587320
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19439702
42Pyrimidine metabolism_Homo sapiens_hsa002401.19352607
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18542813
44Pertussis_Homo sapiens_hsa051331.17963132
45Tuberculosis_Homo sapiens_hsa051521.17754270
46Lysosome_Homo sapiens_hsa041421.16997274
47Arginine biosynthesis_Homo sapiens_hsa002201.16866248
48N-Glycan biosynthesis_Homo sapiens_hsa005101.16412776
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16096216
50Jak-STAT signaling pathway_Homo sapiens_hsa046301.14739579
51Cell cycle_Homo sapiens_hsa041101.14503664
52Hematopoietic cell lineage_Homo sapiens_hsa046401.14378989
53Histidine metabolism_Homo sapiens_hsa003401.13469293
54Linoleic acid metabolism_Homo sapiens_hsa005911.11218475
55Influenza A_Homo sapiens_hsa051641.10987814
56Nucleotide excision repair_Homo sapiens_hsa034201.10747599
57Asthma_Homo sapiens_hsa053101.09395784
58Basal transcription factors_Homo sapiens_hsa030221.09174694
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.08388107
60Fructose and mannose metabolism_Homo sapiens_hsa000511.07507951
61Proteasome_Homo sapiens_hsa030501.06961706
62Toxoplasmosis_Homo sapiens_hsa051451.05499149
63RNA transport_Homo sapiens_hsa030130.99430569
64Allograft rejection_Homo sapiens_hsa053300.96974585
65Retinol metabolism_Homo sapiens_hsa008300.95297623
66PPAR signaling pathway_Homo sapiens_hsa033200.94692436
67Glutathione metabolism_Homo sapiens_hsa004800.94671339
68Chemical carcinogenesis_Homo sapiens_hsa052040.93835575
69Galactose metabolism_Homo sapiens_hsa000520.92958512
70Salmonella infection_Homo sapiens_hsa051320.92943714
71Malaria_Homo sapiens_hsa051440.92499573
72Apoptosis_Homo sapiens_hsa042100.91756052
73B cell receptor signaling pathway_Homo sapiens_hsa046620.88051775
74Phagosome_Homo sapiens_hsa041450.86964125
75Sphingolipid metabolism_Homo sapiens_hsa006000.86712494
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86523207
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85953205
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.85078433
79Spliceosome_Homo sapiens_hsa030400.84925225
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80144174
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.79583817
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78687331
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78599831
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77166140
85Protein digestion and absorption_Homo sapiens_hsa049740.75410668
86Epstein-Barr virus infection_Homo sapiens_hsa051690.74513792
87African trypanosomiasis_Homo sapiens_hsa051430.73797566
88Fatty acid degradation_Homo sapiens_hsa000710.72830139
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71486961
90RNA polymerase_Homo sapiens_hsa030200.70431394
91Vitamin digestion and absorption_Homo sapiens_hsa049770.69082358
92Ether lipid metabolism_Homo sapiens_hsa005650.68229022
93Fat digestion and absorption_Homo sapiens_hsa049750.67598170
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67456503
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65907971
96Purine metabolism_Homo sapiens_hsa002300.65365138
97ABC transporters_Homo sapiens_hsa020100.64848263
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63038276
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62356766
100Systemic lupus erythematosus_Homo sapiens_hsa053220.62005724
101TNF signaling pathway_Homo sapiens_hsa046680.59744541
102Rheumatoid arthritis_Homo sapiens_hsa053230.59359748
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.59296675
104Chemokine signaling pathway_Homo sapiens_hsa040620.58974987
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58661388
106Thyroid cancer_Homo sapiens_hsa052160.58323688
107Shigellosis_Homo sapiens_hsa051310.56459575
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56396168
109Selenocompound metabolism_Homo sapiens_hsa004500.53008956
110Autoimmune thyroid disease_Homo sapiens_hsa053200.52762643
111Bile secretion_Homo sapiens_hsa049760.51228630
112RNA degradation_Homo sapiens_hsa030180.50543792
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50396856
114Pancreatic secretion_Homo sapiens_hsa049720.50357559
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.50035183
116Viral carcinogenesis_Homo sapiens_hsa052030.49705119
117Arginine and proline metabolism_Homo sapiens_hsa003300.49584439
118Glycerolipid metabolism_Homo sapiens_hsa005610.49209090
119Caffeine metabolism_Homo sapiens_hsa002320.47843215
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47620839
121Hepatitis B_Homo sapiens_hsa051610.46175446
122Hepatitis C_Homo sapiens_hsa051600.44935350
123Non-small cell lung cancer_Homo sapiens_hsa052230.44706669
124Acute myeloid leukemia_Homo sapiens_hsa052210.43694035
125Mineral absorption_Homo sapiens_hsa049780.42825706
126T cell receptor signaling pathway_Homo sapiens_hsa046600.42385403
127One carbon pool by folate_Homo sapiens_hsa006700.42334574
128Viral myocarditis_Homo sapiens_hsa054160.42161600
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41838171
130Fatty acid biosynthesis_Homo sapiens_hsa000610.41745623
131Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41443264
132Insulin resistance_Homo sapiens_hsa049310.40953677
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39547751
134Protein export_Homo sapiens_hsa030600.38809060
135Pancreatic cancer_Homo sapiens_hsa052120.37970709
136Tryptophan metabolism_Homo sapiens_hsa003800.29690429

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