GPR12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)6.15349964
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.85259217
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.80579918
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.71003897
5synaptic vesicle exocytosis (GO:0016079)5.61858487
6neuron cell-cell adhesion (GO:0007158)5.52774392
7protein localization to synapse (GO:0035418)5.41166125
8locomotory exploration behavior (GO:0035641)5.24409660
9regulation of glutamate receptor signaling pathway (GO:1900449)5.22687615
10glutamate secretion (GO:0014047)5.04497726
11ionotropic glutamate receptor signaling pathway (GO:0035235)4.88488513
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.85354759
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.81551932
14synaptic vesicle maturation (GO:0016188)4.75732099
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.74198746
16pyrimidine nucleobase catabolic process (GO:0006208)4.69105287
17regulation of synaptic vesicle exocytosis (GO:2000300)4.66215955
18neurotransmitter-gated ion channel clustering (GO:0072578)4.61883805
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.61637624
20neuronal action potential propagation (GO:0019227)4.54623935
21glutamate receptor signaling pathway (GO:0007215)4.46442281
22positive regulation of synapse maturation (GO:0090129)4.45159779
23exploration behavior (GO:0035640)4.38267112
24regulation of neuronal synaptic plasticity (GO:0048168)4.38008031
25neurotransmitter secretion (GO:0007269)4.37573145
26synaptic transmission, glutamatergic (GO:0035249)4.37112697
27neuron-neuron synaptic transmission (GO:0007270)4.33940410
28positive regulation of action potential (GO:0045760)4.25620077
29regulation of synaptic vesicle transport (GO:1902803)4.17299617
30regulation of synapse structural plasticity (GO:0051823)4.15751988
31regulation of excitatory postsynaptic membrane potential (GO:0060079)4.13041134
32nucleobase catabolic process (GO:0046113)4.05385736
33presynaptic membrane assembly (GO:0097105)4.04888690
34negative regulation of dendrite development (GO:2000171)3.96170638
35neuron recognition (GO:0008038)3.95114339
36positive regulation of membrane potential (GO:0045838)3.94951729
37postsynaptic membrane organization (GO:0001941)3.94102798
38regulation of postsynaptic membrane potential (GO:0060078)3.92894156
39gamma-aminobutyric acid transport (GO:0015812)3.90748628
40long-term memory (GO:0007616)3.85276203
41layer formation in cerebral cortex (GO:0021819)3.83914949
42membrane depolarization during action potential (GO:0086010)3.82908903
43long-term synaptic potentiation (GO:0060291)3.82682395
44gamma-aminobutyric acid signaling pathway (GO:0007214)3.82602981
45dendritic spine morphogenesis (GO:0060997)3.78838953
46response to histamine (GO:0034776)3.78570148
47regulation of dendritic spine morphogenesis (GO:0061001)3.76917336
48presynaptic membrane organization (GO:0097090)3.74177438
49regulation of synaptic plasticity (GO:0048167)3.73136085
50auditory behavior (GO:0031223)3.71204840
51regulation of synaptic transmission, glutamatergic (GO:0051966)3.70159255
52positive regulation of neurotransmitter secretion (GO:0001956)3.68794147
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.67287490
54regulation of glutamate secretion (GO:0014048)3.65945841
55regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.64845649
56negative regulation of synaptic transmission, GABAergic (GO:0032229)3.59343867
57axonal fasciculation (GO:0007413)3.59339391
58positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.57836840
59neurotransmitter transport (GO:0006836)3.56555888
60cell migration in hindbrain (GO:0021535)3.53878716
61behavioral response to cocaine (GO:0048148)3.52954119
62transmission of nerve impulse (GO:0019226)3.52052273
63behavioral response to nicotine (GO:0035095)3.46851061
64G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.46780770
65regulation of synapse maturation (GO:0090128)3.46345317
66synaptic vesicle endocytosis (GO:0048488)3.41727167
67positive regulation of neurotransmitter transport (GO:0051590)3.41601183
68proline transport (GO:0015824)3.36324150
69regulation of neurotransmitter levels (GO:0001505)3.36079617
70regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.33166151
71response to auditory stimulus (GO:0010996)3.32956853
72regulation of dendritic spine development (GO:0060998)3.32534260
73positive regulation of synaptic transmission, GABAergic (GO:0032230)3.31969844
74regulation of female receptivity (GO:0045924)3.30289575
75behavioral fear response (GO:0001662)3.29816336
76behavioral defense response (GO:0002209)3.29816336
77learning (GO:0007612)3.28736529
78G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.28050920
79membrane depolarization (GO:0051899)3.28016104
80regulation of vesicle fusion (GO:0031338)3.27576438
81neuronal action potential (GO:0019228)3.27484993
82regulation of neurotransmitter secretion (GO:0046928)3.27185263
83central nervous system projection neuron axonogenesis (GO:0021952)3.26866795
84mechanosensory behavior (GO:0007638)3.23764674
85response to pheromone (GO:0019236)3.22111792
86regulation of action potential (GO:0098900)3.21666353
87negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.21570666
88positive regulation of dendritic spine morphogenesis (GO:0061003)3.18734197
89cerebellar granule cell differentiation (GO:0021707)3.17528637
90neuromuscular process controlling posture (GO:0050884)3.16843977
91female mating behavior (GO:0060180)3.16388957
92startle response (GO:0001964)3.16170468
93positive regulation of dendritic spine development (GO:0060999)3.14164966
94fear response (GO:0042596)3.13967871
95striatum development (GO:0021756)3.13701680
96synapse assembly (GO:0007416)3.12899564
97neuromuscular process controlling balance (GO:0050885)3.12525110
98positive regulation of synaptic transmission (GO:0050806)3.09714081
99serotonin metabolic process (GO:0042428)3.09385484
100social behavior (GO:0035176)3.08673342
101intraspecies interaction between organisms (GO:0051703)3.08673342
102cellular potassium ion homeostasis (GO:0030007)3.07984698
103negative regulation of amino acid transport (GO:0051956)3.06455034
104positive regulation of synapse assembly (GO:0051965)3.03744316
105cerebellar Purkinje cell differentiation (GO:0021702)3.03655679
106regulation of neurotransmitter transport (GO:0051588)3.02988396
107activation of protein kinase A activity (GO:0034199)3.02333470
108prepulse inhibition (GO:0060134)3.02260064
109regulation of synaptic transmission (GO:0050804)3.02208984
110synaptic transmission (GO:0007268)3.01210110
111membrane hyperpolarization (GO:0060081)3.00590561
112synaptic transmission, dopaminergic (GO:0001963)2.99204593
113dendrite morphogenesis (GO:0048813)2.98489126
114negative regulation of dendrite morphogenesis (GO:0050774)2.97664985
115detection of calcium ion (GO:0005513)2.96384400
116neurofilament cytoskeleton organization (GO:0060052)2.96239813
117regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.95542429
118righting reflex (GO:0060013)2.95008698
119primary amino compound metabolic process (GO:1901160)2.94045753
120detection of light stimulus involved in visual perception (GO:0050908)2.93787769
121detection of light stimulus involved in sensory perception (GO:0050962)2.93787769
122glycosphingolipid biosynthetic process (GO:0006688)2.88344222
123negative regulation of cytosolic calcium ion concentration (GO:0051481)2.84172027
124establishment of mitochondrion localization (GO:0051654)2.84102221
125tachykinin receptor signaling pathway (GO:0007217)2.82934807
126neuronal ion channel clustering (GO:0045161)2.82517249
127adult walking behavior (GO:0007628)2.82452896
128regulation of respiratory system process (GO:0044065)2.80625650
129action potential (GO:0001508)2.78578720
130C4-dicarboxylate transport (GO:0015740)2.74720143
131urinary tract smooth muscle contraction (GO:0014848)2.72756495
132glycerophospholipid catabolic process (GO:0046475)2.72074436
133adult behavior (GO:0030534)2.71793299
134regulation of voltage-gated calcium channel activity (GO:1901385)2.70530360
135response to amphetamine (GO:0001975)2.70173080
136neurotransmitter uptake (GO:0001504)2.69454066
137behavioral response to ethanol (GO:0048149)2.67800357

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.47008847
2GBX2_23144817_ChIP-Seq_PC3_Human4.06729029
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.24841131
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.17024950
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12262325
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.70688359
7* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.69688364
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66716757
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66716757
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62484753
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.59908792
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.53894979
13* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52259205
14* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51740765
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47483115
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47074223
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.30394115
18TAF15_26573619_Chip-Seq_HEK293_Human2.27096821
19DROSHA_22980978_ChIP-Seq_HELA_Human2.24126110
20* REST_18959480_ChIP-ChIP_MESCs_Mouse2.20759481
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20409048
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.20114325
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.14809679
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.14228371
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.09495679
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08859206
27AR_21572438_ChIP-Seq_LNCaP_Human2.08521422
28SALL1_21062744_ChIP-ChIP_HESCs_Human2.03695012
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01795769
30CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00646920
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.85106783
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.83018307
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73821189
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71340489
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.70908422
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68771808
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.60199914
38* P300_19829295_ChIP-Seq_ESCs_Human1.59188346
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49723607
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49142697
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.48321010
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46212958
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.44088950
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42244814
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41376857
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.39882971
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38760893
48AR_25329375_ChIP-Seq_VCAP_Human1.37394187
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36726380
50* SOX2_21211035_ChIP-Seq_LN229_Gbm1.36303756
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35650503
52* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33921325
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33294689
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32983247
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32950518
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32101720
57EWS_26573619_Chip-Seq_HEK293_Human1.31610793
58ZNF274_21170338_ChIP-Seq_K562_Hela1.31230219
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30647454
60CBP_20019798_ChIP-Seq_JUKART_Human1.30647454
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29962426
62* PIAS1_25552417_ChIP-Seq_VCAP_Human1.27767401
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.26475955
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26269438
65STAT3_23295773_ChIP-Seq_U87_Human1.25514147
66* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25386889
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24654454
68RING1B_27294783_Chip-Seq_ESCs_Mouse1.24128291
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22147891
70TP53_22573176_ChIP-Seq_HFKS_Human1.19375339
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19209132
72FUS_26573619_Chip-Seq_HEK293_Human1.18021048
73AR_19668381_ChIP-Seq_PC3_Human1.15043633
74FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13910794
75RNF2_27304074_Chip-Seq_NSC_Mouse1.13777986
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13751444
77RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13728152
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13377476
79TCF4_23295773_ChIP-Seq_U87_Human1.13269154
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.10289387
81* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09752480
82TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09413428
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09102590
84DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08833039
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.08713790
86P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07459519
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07421935
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06139208
89RING1B_27294783_Chip-Seq_NPCs_Mouse1.05459911
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04950088
91P53_22387025_ChIP-Seq_ESCs_Mouse1.04840992
92* RUNX2_22187159_ChIP-Seq_PCA_Human1.04642980
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.04290776
94AHR_22903824_ChIP-Seq_MCF-7_Human1.03329924
95TCF4_22108803_ChIP-Seq_LS180_Human1.03295791
96WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02692742
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02651929
98NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02572331
99TAL1_26923725_Chip-Seq_HPCs_Mouse1.01834856
100BCAT_22108803_ChIP-Seq_LS180_Human1.01283582
101PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00257266
102YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00107533
103ER_23166858_ChIP-Seq_MCF-7_Human1.00040616
104SMAD4_21741376_ChIP-Seq_EPCs_Human0.99440764
105NFE2_27457419_Chip-Seq_LIVER_Mouse0.99042619
106* JUN_21703547_ChIP-Seq_K562_Human0.97749086
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96919054
108BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.96481812
109TP53_16413492_ChIP-PET_HCT116_Human0.95891356
110NANOG_18555785_Chip-Seq_ESCs_Mouse0.94954431
111CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94948848
112PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94426888
113IGF1R_20145208_ChIP-Seq_DFB_Human0.93529928
114VDR_22108803_ChIP-Seq_LS180_Human0.93041319
115* TP53_18474530_ChIP-ChIP_U2OS_Human0.92851663
116RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88239237
117SMAD3_21741376_ChIP-Seq_HESCs_Human0.87668423
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87358376
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87358376
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.86281250
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86251814
122* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86067009
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85958164

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.38968247
2MP0003880_abnormal_central_pattern5.68512294
3MP0003635_abnormal_synaptic_transmissio4.29479735
4MP0002822_catalepsy3.82359392
5MP0009745_abnormal_behavioral_response3.68134315
6MP0002063_abnormal_learning/memory/cond3.52370129
7MP0004270_analgesia3.51461224
8MP0002064_seizures3.26716078
9MP0009046_muscle_twitch3.16862974
10MP0001968_abnormal_touch/_nociception3.10120362
11MP0002572_abnormal_emotion/affect_behav2.99062062
12MP0002272_abnormal_nervous_system2.56418462
13MP0001486_abnormal_startle_reflex2.51524342
14MP0002736_abnormal_nociception_after2.51358504
15MP0002734_abnormal_mechanical_nocicepti2.45368879
16MP0002735_abnormal_chemical_nociception2.42675345
17MP0001501_abnormal_sleep_pattern2.39393080
18MP0005423_abnormal_somatic_nervous2.33487144
19MP0001440_abnormal_grooming_behavior2.19744076
20MP0009780_abnormal_chondrocyte_physiolo2.15689567
21MP0002067_abnormal_sensory_capabilities2.06761409
22MP0008877_abnormal_DNA_methylation2.01486655
23MP0002733_abnormal_thermal_nociception2.00295139
24MP0006276_abnormal_autonomic_nervous1.92013269
25MP0001529_abnormal_vocalization1.91188663
26MP0001970_abnormal_pain_threshold1.88477137
27MP0005386_behavior/neurological_phenoty1.86082027
28MP0004924_abnormal_behavior1.86082027
29MP0002557_abnormal_social/conspecific_i1.85156746
30MP0003329_amyloid_beta_deposits1.84802635
31MP0000778_abnormal_nervous_system1.84075181
32MP0001984_abnormal_olfaction1.81699238
33MP0002184_abnormal_innervation1.77182181
34MP0003879_abnormal_hair_cell1.67360177
35MP0008569_lethality_at_weaning1.66178052
36MP0002909_abnormal_adrenal_gland1.63710493
37MP0004811_abnormal_neuron_physiology1.61864568
38MP0001905_abnormal_dopamine_level1.56633666
39MP0005646_abnormal_pituitary_gland1.51382251
40MP0002102_abnormal_ear_morphology1.47868594
41MP0003121_genomic_imprinting1.45394373
42MP0002066_abnormal_motor_capabilities/c1.42380363
43MP0001986_abnormal_taste_sensitivity1.41136215
44MP0000955_abnormal_spinal_cord1.40579474
45MP0002837_dystrophic_cardiac_calcinosis1.36111771
46MP0002882_abnormal_neuron_morphology1.33556873
47MP0004858_abnormal_nervous_system1.33041502
48MP0001188_hyperpigmentation1.32774683
49MP0003787_abnormal_imprinting1.32229679
50MP0001502_abnormal_circadian_rhythm1.27247008
51MP0003633_abnormal_nervous_system1.26112359
52MP0004147_increased_porphyrin_level1.25311954
53MP0004142_abnormal_muscle_tone1.24048458
54MP0004885_abnormal_endolymph1.19590587
55MP0005645_abnormal_hypothalamus_physiol1.14361234
56MP0002653_abnormal_ependyma_morphology1.14286535
57MP0003631_nervous_system_phenotype1.11776955
58MP0002152_abnormal_brain_morphology1.08094311
59MP0008872_abnormal_physiological_respon1.06249248
60MP0003122_maternal_imprinting1.06194471
61MP0008874_decreased_physiological_sensi1.03918021
62MP0005253_abnormal_eye_physiology1.00179380
63MP0002234_abnormal_pharynx_morphology0.96888383
64MP0006072_abnormal_retinal_apoptosis0.95113486
65MP0002069_abnormal_eating/drinking_beha0.94774036
66MP0000751_myopathy0.93319264
67MP0010386_abnormal_urinary_bladder0.93173288
68MP0004742_abnormal_vestibular_system0.90472629
69MP0005535_abnormal_body_temperature0.90426385
70MP0002876_abnormal_thyroid_physiology0.90260251
71MP0002229_neurodegeneration0.88307951
72MP0004133_heterotaxia0.88172918
73MP0005551_abnormal_eye_electrophysiolog0.87158313
74MP0000604_amyloidosis0.87089891
75MP0000569_abnormal_digit_pigmentation0.86155551
76MP0004085_abnormal_heartbeat0.84466816
77MP0002090_abnormal_vision0.84279427
78MP0005394_taste/olfaction_phenotype0.84222744
79MP0005499_abnormal_olfactory_system0.84222744
80MP0001963_abnormal_hearing_physiology0.83380695
81MP0000013_abnormal_adipose_tissue0.82789243
82MP0001177_atelectasis0.82601453
83MP0006292_abnormal_olfactory_placode0.82258718
84MP0003632_abnormal_nervous_system0.78439887
85MP0004145_abnormal_muscle_electrophysio0.76223174
86MP0002751_abnormal_autonomic_nervous0.75897514
87MP0000631_abnormal_neuroendocrine_gland0.75019374
88MP0004043_abnormal_pH_regulation0.74649383
89MP0000427_abnormal_hair_cycle0.73952319
90MP0003075_altered_response_to0.73884051
91MP0008961_abnormal_basal_metabolism0.73693034
92MP0003011_delayed_dark_adaptation0.71998721
93MP0005409_darkened_coat_color0.71216146
94MP0001664_abnormal_digestion0.69931181
95MP0008875_abnormal_xenobiotic_pharmacok0.69906546
96MP0002752_abnormal_somatic_nervous0.68674006
97MP0002928_abnormal_bile_duct0.68012470
98MP0003634_abnormal_glial_cell0.67420841
99MP0003698_abnormal_male_reproductive0.66733095
100MP0005195_abnormal_posterior_eye0.66589878
101MP0004215_abnormal_myocardial_fiber0.66256623
102MP0004484_altered_response_of0.66002987
103MP0003646_muscle_fatigue0.65681070
104MP0002277_abnormal_respiratory_mucosa0.64584742
105MP0003690_abnormal_glial_cell0.63833694
106MP0003119_abnormal_digestive_system0.63053322
107MP0003183_abnormal_peptide_metabolism0.61599059
108MP0002160_abnormal_reproductive_system0.59864808
109MP0005084_abnormal_gallbladder_morpholo0.58061925
110MP0003137_abnormal_impulse_conducting0.57445269
111MP0002095_abnormal_skin_pigmentation0.57148377
112MP0000920_abnormal_myelination0.55309845
113MP0001943_abnormal_respiration0.54920330
114MP0001485_abnormal_pinna_reflex0.54859497
115MP0002638_abnormal_pupillary_reflex0.51532463
116MP0010770_preweaning_lethality0.50799262
117MP0002082_postnatal_lethality0.50799262
118MP0005171_absent_coat_pigmentation0.50572008
119MP0005187_abnormal_penis_morphology0.50365862
120MP0010769_abnormal_survival0.50219995
121* MP0003956_abnormal_body_size0.50188456
122MP0000026_abnormal_inner_ear0.50082521
123MP0003861_abnormal_nervous_system0.50020033
124MP0004510_myositis0.48704891
125MP0010768_mortality/aging0.47082059

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.62735988
2Myokymia (HP:0002411)6.44817737
3Focal seizures (HP:0007359)5.90322149
4Visual hallucinations (HP:0002367)5.64807011
5Epileptic encephalopathy (HP:0200134)5.57409398
6Hyperventilation (HP:0002883)5.14779593
7Atonic seizures (HP:0010819)4.93844663
8Progressive cerebellar ataxia (HP:0002073)4.77411178
9Absence seizures (HP:0002121)4.51029177
10Febrile seizures (HP:0002373)4.33757939
11Broad-based gait (HP:0002136)4.18468224
12Dialeptic seizures (HP:0011146)4.16597169
13Generalized tonic-clonic seizures (HP:0002069)4.11538825
14Poor eye contact (HP:0000817)3.66431109
15Amblyopia (HP:0000646)3.47480329
16Gaze-evoked nystagmus (HP:0000640)3.38766951
17Abnormal social behavior (HP:0012433)3.35721193
18Impaired social interactions (HP:0000735)3.35721193
19Supranuclear gaze palsy (HP:0000605)3.22564539
20Excessive salivation (HP:0003781)3.19453417
21Drooling (HP:0002307)3.19453417
22Cerebral inclusion bodies (HP:0100314)3.17165474
23Dysdiadochokinesis (HP:0002075)3.11707535
24Action tremor (HP:0002345)3.08201501
25Epileptiform EEG discharges (HP:0011182)3.05883604
26Impaired vibration sensation in the lower limbs (HP:0002166)3.02728198
27Anxiety (HP:0000739)3.02097294
28Urinary bladder sphincter dysfunction (HP:0002839)3.01719227
29Termporal pattern (HP:0011008)2.99111901
30Insidious onset (HP:0003587)2.99111901
31Truncal ataxia (HP:0002078)2.97960439
32Depression (HP:0000716)2.91685322
33Dysmetria (HP:0001310)2.91146193
34Progressive inability to walk (HP:0002505)2.87043715
35EEG with generalized epileptiform discharges (HP:0011198)2.87008780
36Abnormal eating behavior (HP:0100738)2.78577483
37Type II lissencephaly (HP:0007260)2.78454775
38Abnormality of the labia minora (HP:0012880)2.76357287
39Inability to walk (HP:0002540)2.75332361
40Limb dystonia (HP:0002451)2.74592139
41Ankle clonus (HP:0011448)2.70639553
42Hypsarrhythmia (HP:0002521)2.70217788
43Neurofibrillary tangles (HP:0002185)2.68367895
44Absent speech (HP:0001344)2.67329085
45Hemiparesis (HP:0001269)2.65311300
46Genetic anticipation (HP:0003743)2.63717642
47Congenital stationary night blindness (HP:0007642)2.63474188
48Postural instability (HP:0002172)2.61298212
49Pancreatic cysts (HP:0001737)2.60558736
50Torticollis (HP:0000473)2.59397004
51Status epilepticus (HP:0002133)2.59246208
52Focal dystonia (HP:0004373)2.57939745
53Diplopia (HP:0000651)2.56361235
54Abnormality of binocular vision (HP:0011514)2.56361235
55Stereotypic behavior (HP:0000733)2.55340998
56Protruding tongue (HP:0010808)2.52676711
57Mutism (HP:0002300)2.49783423
58Impaired smooth pursuit (HP:0007772)2.48951508
59Papilledema (HP:0001085)2.48724838
60Generalized myoclonic seizures (HP:0002123)2.48546606
61Nephronophthisis (HP:0000090)2.47562089
62True hermaphroditism (HP:0010459)2.47011696
63Scanning speech (HP:0002168)2.44969019
64Cerebral hypomyelination (HP:0006808)2.44326056
65Abnormality of midbrain morphology (HP:0002418)2.43026593
66Molar tooth sign on MRI (HP:0002419)2.43026593
67Urinary urgency (HP:0000012)2.41439430
68Polyphagia (HP:0002591)2.39442511
69Bradykinesia (HP:0002067)2.39431442
70Abnormality of the lower motor neuron (HP:0002366)2.35890980
71Pheochromocytoma (HP:0002666)2.35733387
72Hypothermia (HP:0002045)2.34174681
73Gait imbalance (HP:0002141)2.31907815
74Spastic gait (HP:0002064)2.30694875
75Dysmetric saccades (HP:0000641)2.30005533
76Neuroendocrine neoplasm (HP:0100634)2.29770726
77Pancreatic fibrosis (HP:0100732)2.27610966
78Craniofacial dystonia (HP:0012179)2.24333329
79Fetal akinesia sequence (HP:0001989)2.23167560
80Pachygyria (HP:0001302)2.19394682
81Impaired vibratory sensation (HP:0002495)2.17581893
82Abnormality of the corticospinal tract (HP:0002492)2.15875687
83Blue irides (HP:0000635)2.15313992
84Delusions (HP:0000746)2.14279329
85Abnormality of ocular smooth pursuit (HP:0000617)2.13562681
86Pendular nystagmus (HP:0012043)2.12507597
87Optic nerve hypoplasia (HP:0000609)2.11888853
88Abnormality of salivation (HP:0100755)2.09599947
89Hemiplegia (HP:0002301)2.07280539
90Abnormality of the renal medulla (HP:0100957)2.06980243
91Resting tremor (HP:0002322)2.06976053
92Thyroid-stimulating hormone excess (HP:0002925)2.04836470
93Psychosis (HP:0000709)2.04609675
94Amyotrophic lateral sclerosis (HP:0007354)2.02279063
95Failure to thrive in infancy (HP:0001531)2.01638946
96Generalized hypopigmentation of hair (HP:0011358)2.01058465
97Megalencephaly (HP:0001355)2.00722268
98Spastic tetraplegia (HP:0002510)2.00449652
99Incomplete penetrance (HP:0003829)1.99380372
100Decreased central vision (HP:0007663)1.97815732
101Nephrogenic diabetes insipidus (HP:0009806)1.97512250
102Hypoplasia of the brainstem (HP:0002365)1.97500060
103Aplasia/Hypoplasia of the brainstem (HP:0007362)1.97500060
104Abnormal rod and cone electroretinograms (HP:0008323)1.96609972
105Spastic tetraparesis (HP:0001285)1.96339758
106Lower limb muscle weakness (HP:0007340)1.94913000
107Specific learning disability (HP:0001328)1.94814453
108Fair hair (HP:0002286)1.93237153
109Gait ataxia (HP:0002066)1.92980873
110Abolished electroretinogram (ERG) (HP:0000550)1.90313891
111Morphological abnormality of the pyramidal tract (HP:0002062)1.89472222
112Intention tremor (HP:0002080)1.88960471
113Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86680880
114Abnormal drinking behavior (HP:0030082)1.86049786
115Polydipsia (HP:0001959)1.86049786
116Abnormality of the renal cortex (HP:0011035)1.84020327
117Lower limb amyotrophy (HP:0007210)1.83936157
118Congenital primary aphakia (HP:0007707)1.83845345
119Annular pancreas (HP:0001734)1.83334883
120Severe muscular hypotonia (HP:0006829)1.83143382
121Dyskinesia (HP:0100660)1.82244599
122Attenuation of retinal blood vessels (HP:0007843)1.81975017
123Muscular hypotonia of the trunk (HP:0008936)1.81617563
124Hyperthyroidism (HP:0000836)1.79968803
125Agitation (HP:0000713)1.79296988
126Esotropia (HP:0000565)1.79248399
127Inappropriate behavior (HP:0000719)1.77007295
128Vaginal atresia (HP:0000148)1.76466741
129Akinesia (HP:0002304)1.76328717
130Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.75979439
131Degeneration of the lateral corticospinal tracts (HP:0002314)1.75979439
132Genital tract atresia (HP:0001827)1.75795799
133Oligodactyly (hands) (HP:0001180)1.75734122
134Retinal dysplasia (HP:0007973)1.75470364
135Methylmalonic acidemia (HP:0002912)1.75372952
136Intellectual disability, severe (HP:0010864)1.73489583
137Cerebellar dysplasia (HP:0007033)1.73359359
138Lissencephaly (HP:0001339)1.73164571
139Medial flaring of the eyebrow (HP:0010747)1.72514642
140Cystic liver disease (HP:0006706)1.71639241
141Horizontal nystagmus (HP:0000666)1.70770103
142Rapidly progressive (HP:0003678)1.70036894
143Obstructive sleep apnea (HP:0002870)1.69961939

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.03735289
2NTRK34.24773289
3MAP3K93.79037278
4CASK3.41212038
5MAP3K43.22515061
6MARK13.12112520
7MAP3K122.99703407
8MAP2K72.86382345
9FRK2.67538013
10DAPK22.64155493
11WNK32.48903034
12MINK12.46115707
13MAP4K22.41508053
14RIPK42.40110333
15PINK12.23002015
16MAP2K42.20154114
17NTRK21.92462140
18DAPK11.91490589
19PLK21.89777117
20TNIK1.79569476
21PNCK1.75689655
22PAK61.68187877
23DYRK21.68146383
24CDK191.63739620
25KSR21.63498827
26ADRBK21.62559681
27SIK21.61541205
28KSR11.58898675
29GRK51.57443473
30BMPR1B1.56941234
31PRPF4B1.51035779
32CAMKK11.49198634
33CDK51.44748891
34NTRK11.43418548
35FES1.38154619
36ERBB31.37988258
37MAPK131.33402247
38ARAF1.29506737
39MAP3K131.25243422
40BCKDK1.21121962
41PRKCG1.21109419
42BCR1.20055732
43GRK11.16324306
44ZAK1.15976357
45CAMK2A1.11923123
46CSNK1G31.10514436
47PRKD31.08341240
48PTK2B1.07587049
49CSNK1A1L1.04907916
50CAMKK21.04494301
51CSNK1G11.01954911
52BMPR20.99646698
53FGR0.97834094
54CAMK2B0.97107805
55TAOK30.94180861
56NUAK10.93189669
57INSRR0.90521669
58NME10.88758093
59OXSR10.88052016
60TYRO30.87809691
61STK380.84994564
62CCNB10.83593737
63SGK4940.82973220
64SGK2230.82973220
65CDK180.82252058
66CDK140.80826747
67PHKG10.80781518
68PHKG20.80781518
69STK110.79654742
70CDK150.78992684
71UHMK10.78790566
72WNK40.78380745
73LATS20.74477732
74CAMK10.74299731
75SGK20.73426321
76CSNK1G20.72402831
77SGK10.71177937
78DYRK1A0.69988775
79MAP3K20.68405354
80CDK11A0.67487802
81TRIM280.66927624
82GRK60.66416068
83PKN10.65306768
84RAF10.64972490
85MAPKAPK50.61358905
86LIMK10.61258230
87TLK10.61065026
88MAP3K60.60318900
89MKNK20.59714924
90PRKCE0.58306440
91PRKCH0.55533529
92PAK30.53959984
93RET0.53880568
94PRKCZ0.52376294
95MAPK120.52015095
96PDK10.50465519
97CAMK2D0.50418644
98MARK20.49043524
99CSNK1D0.48941808
100SGK30.48870002
101CSNK1A10.48446093
102SIK30.48390626
103DAPK30.46825869
104PDPK10.45807811
105FYN0.45011544
106TAOK10.44049796
107STK390.43952110
108AKT30.43250431
109MAP3K10.42418950
110RPS6KA30.39703333
111PRKCI0.39648363
112PRKG10.39468464
113RPS6KB10.39051100
114CAMK2G0.37480169
115MAP2K10.35855556
116PIK3CA0.35509021
117MUSK0.34909757
118MAPK100.34795655
119FER0.34647858
120MAP3K70.34387812
121CAMK40.33356238
122ADRBK10.33287944
123CAMK1G0.33156231
124TIE10.32598653
125PRKCB0.32130467
126PIM20.31414451
127ROCK20.31078522
128PRKACA0.29481819
129ACVR1B0.29426443
130ALK0.28813402
131RPS6KA50.28604349
132KIT0.28079262
133LMTK20.27342427
134GRK70.26320388
135MOS0.25953458
136MAP3K110.25821472
137PRKCA0.25610204

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.19646902
2Synaptic vesicle cycle_Homo sapiens_hsa047213.37713652
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.95934114
4Long-term potentiation_Homo sapiens_hsa047202.82575827
5GABAergic synapse_Homo sapiens_hsa047272.78973256
6Olfactory transduction_Homo sapiens_hsa047402.77945650
7Circadian entrainment_Homo sapiens_hsa047132.76362678
8Morphine addiction_Homo sapiens_hsa050322.68621802
9Amphetamine addiction_Homo sapiens_hsa050312.66404277
10Glutamatergic synapse_Homo sapiens_hsa047242.64836559
11Dopaminergic synapse_Homo sapiens_hsa047282.31045903
12Salivary secretion_Homo sapiens_hsa049702.17199146
13Collecting duct acid secretion_Homo sapiens_hsa049661.94338273
14Cholinergic synapse_Homo sapiens_hsa047251.90910234
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90589471
16Insulin secretion_Homo sapiens_hsa049111.89587336
17Renin secretion_Homo sapiens_hsa049241.89230110
18Taste transduction_Homo sapiens_hsa047421.87532029
19Serotonergic synapse_Homo sapiens_hsa047261.80215181
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78774164
21Gastric acid secretion_Homo sapiens_hsa049711.76216173
22Cocaine addiction_Homo sapiens_hsa050301.75730281
23Long-term depression_Homo sapiens_hsa047301.71583128
24Oxytocin signaling pathway_Homo sapiens_hsa049211.68771857
25Calcium signaling pathway_Homo sapiens_hsa040201.67736770
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62404175
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56070947
28GnRH signaling pathway_Homo sapiens_hsa049121.37769983
29Gap junction_Homo sapiens_hsa045401.33179790
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.33065005
31Linoleic acid metabolism_Homo sapiens_hsa005911.32211425
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25343074
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24824780
34Ether lipid metabolism_Homo sapiens_hsa005651.23981435
35cAMP signaling pathway_Homo sapiens_hsa040241.18044935
36Cardiac muscle contraction_Homo sapiens_hsa042601.17492376
37Axon guidance_Homo sapiens_hsa043601.17106414
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16079936
39Vibrio cholerae infection_Homo sapiens_hsa051101.12743192
40Estrogen signaling pathway_Homo sapiens_hsa049151.09914987
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07105917
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06545933
43Type II diabetes mellitus_Homo sapiens_hsa049301.02776904
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01665181
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00425197
46Glioma_Homo sapiens_hsa052140.99969473
47Melanogenesis_Homo sapiens_hsa049160.98721190
48Oxidative phosphorylation_Homo sapiens_hsa001900.98396657
49Alzheimers disease_Homo sapiens_hsa050100.96214280
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95553405
51ErbB signaling pathway_Homo sapiens_hsa040120.94993534
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94886532
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94708302
54Phototransduction_Homo sapiens_hsa047440.93497733
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93217538
56Selenocompound metabolism_Homo sapiens_hsa004500.92060658
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.87977481
58Protein export_Homo sapiens_hsa030600.81213108
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73935533
60Oocyte meiosis_Homo sapiens_hsa041140.73715274
61Parkinsons disease_Homo sapiens_hsa050120.73516038
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72706352
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.71710653
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69700313
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.68985328
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68967564
67Pancreatic secretion_Homo sapiens_hsa049720.68640385
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68629164
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67013247
70Choline metabolism in cancer_Homo sapiens_hsa052310.64131383
71MAPK signaling pathway_Homo sapiens_hsa040100.62910630
72Thyroid hormone synthesis_Homo sapiens_hsa049180.62721898
73Glucagon signaling pathway_Homo sapiens_hsa049220.61241678
74Dilated cardiomyopathy_Homo sapiens_hsa054140.60807221
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58761298
76Dorso-ventral axis formation_Homo sapiens_hsa043200.58027078
77Butanoate metabolism_Homo sapiens_hsa006500.55749290
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55655445
79Alcoholism_Homo sapiens_hsa050340.54743938
80RNA polymerase_Homo sapiens_hsa030200.52877480
81Ras signaling pathway_Homo sapiens_hsa040140.51969378
82Type I diabetes mellitus_Homo sapiens_hsa049400.51895953
83Circadian rhythm_Homo sapiens_hsa047100.50279483
84Nitrogen metabolism_Homo sapiens_hsa009100.49231390
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48635972
86Regulation of autophagy_Homo sapiens_hsa041400.48618884
87Tryptophan metabolism_Homo sapiens_hsa003800.48302392
88African trypanosomiasis_Homo sapiens_hsa051430.48145424
89Propanoate metabolism_Homo sapiens_hsa006400.48004963
90VEGF signaling pathway_Homo sapiens_hsa043700.47306968
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47078584
92Rap1 signaling pathway_Homo sapiens_hsa040150.45569160
93beta-Alanine metabolism_Homo sapiens_hsa004100.43430033
94Peroxisome_Homo sapiens_hsa041460.42908690
95Bile secretion_Homo sapiens_hsa049760.42333126
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.41708991
97Huntingtons disease_Homo sapiens_hsa050160.41517050
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40941131
99Vitamin B6 metabolism_Homo sapiens_hsa007500.40764671
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40657812
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37339470
102Prion diseases_Homo sapiens_hsa050200.36645475
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.35993597
104Basal transcription factors_Homo sapiens_hsa030220.35567517
105Fatty acid biosynthesis_Homo sapiens_hsa000610.35099286
106Inositol phosphate metabolism_Homo sapiens_hsa005620.34732241
107Wnt signaling pathway_Homo sapiens_hsa043100.34137042
108Purine metabolism_Homo sapiens_hsa002300.33450842
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32210213
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31255279
111Rheumatoid arthritis_Homo sapiens_hsa053230.29691868
112Renal cell carcinoma_Homo sapiens_hsa052110.29183100
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28237101
114Mineral absorption_Homo sapiens_hsa049780.28193897
115Fanconi anemia pathway_Homo sapiens_hsa034600.28115761
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27729234
117Insulin signaling pathway_Homo sapiens_hsa049100.27678111
118Non-small cell lung cancer_Homo sapiens_hsa052230.27654495
119Caffeine metabolism_Homo sapiens_hsa002320.26209338
120Arachidonic acid metabolism_Homo sapiens_hsa005900.25566184
121RNA degradation_Homo sapiens_hsa030180.25487981
122Endocytosis_Homo sapiens_hsa041440.25270325
123ABC transporters_Homo sapiens_hsa020100.24782490
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23725099
125Histidine metabolism_Homo sapiens_hsa003400.23406313
126Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21608095
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.21438910
128Ovarian steroidogenesis_Homo sapiens_hsa049130.20664244
129Chemokine signaling pathway_Homo sapiens_hsa040620.20400446
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20102740

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