GPIHBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a capillary endothelial cell protein that facilitates the lipolytic processing of triglyceride-rich lipoproteins. The encoded protein is a glycosylphosphatidylinositol-anchored protein that is a member of the lymphocyte antigen 6 (Ly6) family. This protein plays a major role in transporting lipoprotein lipase (LPL) from the subendothelial spaces to the capillary lumen. Mutations in this gene are the cause of hyperlipoproteinemia, type 1D. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adhesion of symbiont to host (GO:0044406)7.63178414
2lymph vessel development (GO:0001945)6.84131858
3triglyceride catabolic process (GO:0019433)6.25343367
4adhesion of symbiont to host cell (GO:0044650)6.05570545
5virion attachment to host cell (GO:0019062)6.05570545
6neutral lipid catabolic process (GO:0046461)5.64162793
7acylglycerol catabolic process (GO:0046464)5.64162793
8peripheral nervous system neuron development (GO:0048935)5.44983450
9endothelium development (GO:0003158)5.19050233
10NADH metabolic process (GO:0006734)5.02754583
11blood vessel maturation (GO:0001955)4.94781135
12establishment of endothelial barrier (GO:0061028)4.91432697
13positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)4.88631464
14regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)4.88631464
15lymphangiogenesis (GO:0001946)4.75483738
16response to dietary excess (GO:0002021)4.43406525
17endothelial tube morphogenesis (GO:0061154)4.43312975
18morphogenesis of an endothelium (GO:0003159)4.43312975
19histamine secretion (GO:0001821)4.38960929
20regulation of endothelial cell differentiation (GO:0045601)4.38037865
21positive regulation of vasculogenesis (GO:2001214)4.37105124
22glycerolipid catabolic process (GO:0046503)4.26103930
23cellular response to epinephrine stimulus (GO:0071872)4.15054596
24embryonic heart tube development (GO:0035050)4.14174458
25regulation of sarcomere organization (GO:0060297)4.13878328
26creatine metabolic process (GO:0006600)4.12703568
27blood vessel endothelial cell migration (GO:0043534)4.05463386
28low-density lipoprotein particle clearance (GO:0034383)3.97915019
29protein kinase C signaling (GO:0070528)3.97181716
30ovulation from ovarian follicle (GO:0001542)3.94966343
31vascular endothelial growth factor signaling pathway (GO:0038084)3.94359270
32regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.92108819
33regulation of MHC class I biosynthetic process (GO:0045343)3.91453037
34phagocytosis, recognition (GO:0006910)3.86271638
35retina vasculature morphogenesis in camera-type eye (GO:0061299)3.83273220
36negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.81362523
37positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.81216595
38actin-myosin filament sliding (GO:0033275)3.79585182
39muscle filament sliding (GO:0030049)3.79585182
40angiogenesis involved in wound healing (GO:0060055)3.77398956
41fatty acid homeostasis (GO:0055089)3.74086690
42negative regulation of blood vessel endothelial cell migration (GO:0043537)3.73014533
43leukocyte tethering or rolling (GO:0050901)3.71911815
44positive regulation of keratinocyte differentiation (GO:0045618)3.69601317
45cAMP biosynthetic process (GO:0006171)3.65352449
46negative regulation of platelet activation (GO:0010544)3.65257132
47endothelial cell morphogenesis (GO:0001886)3.64535711
48regulation of vasculogenesis (GO:2001212)3.61253767
49sarcoplasmic reticulum calcium ion transport (GO:0070296)3.57097542
50lipid particle organization (GO:0034389)3.55822032
51response to epinephrine (GO:0071871)3.55092603
52negative regulation of endothelial cell migration (GO:0010596)3.54850321
53lipid storage (GO:0019915)3.52715604
54cell adhesion mediated by integrin (GO:0033627)3.52398941
55regulation of skeletal muscle contraction (GO:0014819)3.51572740
56negative regulation of amino acid transport (GO:0051956)3.50456548
57natural killer cell activation involved in immune response (GO:0002323)3.48523670
58positive regulation of nitric-oxide synthase activity (GO:0051000)3.46272918
59regulation of cAMP-dependent protein kinase activity (GO:2000479)3.45046260
60heart trabecula formation (GO:0060347)3.43193988
61negative regulation of endothelial cell apoptotic process (GO:2000352)3.42817630
62cGMP-mediated signaling (GO:0019934)3.42669334
63positive regulation of endothelial cell differentiation (GO:0045603)3.41399554
64regulation of tight junction assembly (GO:2000810)3.40540076
65cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.39942995
66positive regulation of glomerulus development (GO:0090193)3.38615804
67histamine transport (GO:0051608)3.38509267
68polyol transport (GO:0015791)3.38027443
69positive regulation of lipid storage (GO:0010884)3.36989616
70regulation of cholesterol storage (GO:0010885)3.35743369
71activation of protein kinase A activity (GO:0034199)3.33444357
72endothelial cell development (GO:0001885)3.32922417
73regulation of lipoprotein metabolic process (GO:0050746)3.32802014
74regulation of glycogen (starch) synthase activity (GO:2000465)3.31462394
75mRNA transcription from RNA polymerase II promoter (GO:0042789)3.30870376
76leukocyte migration involved in inflammatory response (GO:0002523)3.30723112
77positive regulation of urine volume (GO:0035810)3.28763461
78regulation of integrin activation (GO:0033623)3.26286775
79oxaloacetate metabolic process (GO:0006107)3.25712409
80positive regulation of receptor recycling (GO:0001921)3.25025789
81endothelial cell differentiation (GO:0045446)3.19873754
82negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.18809066
83membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.18517335
84ethanol oxidation (GO:0006069)3.17553856
85glycogen catabolic process (GO:0005980)3.16905592
86ventricular trabecula myocardium morphogenesis (GO:0003222)3.14026434
87diacylglycerol metabolic process (GO:0046339)3.13817421
88detection of calcium ion (GO:0005513)3.11427816
89Notch signaling involved in heart development (GO:0061314)3.07503632
90regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.07485093
91negative regulation of endothelial cell proliferation (GO:0001937)3.06413348
92regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.05495364
93regulation of blood vessel endothelial cell migration (GO:0043535)3.05208649
94vasculogenesis (GO:0001570)3.04763767
95actin-mediated cell contraction (GO:0070252)3.04288244
96positive regulation of glucose import (GO:0046326)3.03514140
97regulation of endothelial cell apoptotic process (GO:2000351)3.03069815
98regulation of endothelial cell migration (GO:0010594)3.02898989
99regulation of phospholipid biosynthetic process (GO:0071071)3.02781568
100positive regulation of blood coagulation (GO:0030194)3.02745333
101positive regulation of hemostasis (GO:1900048)3.02745333
102patterning of blood vessels (GO:0001569)3.02037678
103negative regulation of coagulation (GO:0050819)3.00920646
104protein heterotrimerization (GO:0070208)2.98355545
105megakaryocyte development (GO:0035855)2.97774226
106skeletal muscle contraction (GO:0003009)2.96955607
107negative regulation of blood coagulation (GO:0030195)2.96077021
108negative regulation of hemostasis (GO:1900047)2.96077021
109cellular response to catecholamine stimulus (GO:0071870)2.94916850
110cellular response to monoamine stimulus (GO:0071868)2.94916850
111glomerular filtration (GO:0003094)2.94359850
112glucan catabolic process (GO:0009251)2.93901368
113negative regulation of nitric-oxide synthase activity (GO:0051001)2.91985369
114regulation of platelet activation (GO:0010543)2.90282695
115positive regulation of cellular response to insulin stimulus (GO:1900078)2.88995047
116regulation of cell communication by electrical coupling (GO:0010649)2.88666570
117cardiac muscle contraction (GO:0060048)2.86115044
118myofibril assembly (GO:0030239)2.85912638
119negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.85792359
120heart trabecula morphogenesis (GO:0061384)2.85470008
121brown fat cell differentiation (GO:0050873)2.85135607
122fatty acid transmembrane transport (GO:1902001)2.84684217
123striated muscle contraction (GO:0006941)2.84663351
124trabecula morphogenesis (GO:0061383)2.84278992
125cyclic purine nucleotide metabolic process (GO:0052652)2.83064533
126mRNA transcription (GO:0009299)2.82523515
127venous blood vessel morphogenesis (GO:0048845)2.81577467
128detection of molecule of bacterial origin (GO:0032490)2.81335719
129regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.80566776
130endocrine hormone secretion (GO:0060986)2.79821198
131negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.76862239
132positive regulation of coagulation (GO:0050820)2.76840938
133negative regulation of granulocyte differentiation (GO:0030853)2.76320052
134barbed-end actin filament capping (GO:0051016)2.75336641
135response to leptin (GO:0044321)2.75201386
136neuronal ion channel clustering (GO:0045161)2.74979996
137regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.74868089
138negative regulation of smooth muscle cell proliferation (GO:0048662)2.72981344
139positive regulation of endothelial cell migration (GO:0010595)2.72308291
140renal filtration (GO:0097205)2.71327100
141white fat cell differentiation (GO:0050872)2.70828727
142cellular polysaccharide catabolic process (GO:0044247)2.70534474
143negative regulation of epithelial cell migration (GO:0010633)2.70072278
144cyclic nucleotide biosynthetic process (GO:0009190)2.69268406
145surfactant homeostasis (GO:0043129)2.68537084
146regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.68453302
147regulation of synapse maturation (GO:0090128)2.67751557
148positive regulation of odontogenesis (GO:0042482)2.67691176
149positive regulation of glucose transport (GO:0010828)2.67390804
150sprouting angiogenesis (GO:0002040)2.66634786
151cell migration involved in sprouting angiogenesis (GO:0002042)2.66552752
152regulation of cellular extravasation (GO:0002691)2.64473954
153regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.64057395
154purine nucleotide salvage (GO:0032261)2.63635360
155negative regulation of fibrinolysis (GO:0051918)2.62974816
156lung vasculature development (GO:0060426)2.62245049
157negative regulation of lipid storage (GO:0010888)2.62082505
158cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.61930062
159* transcytosis (GO:0045056)2.61722942
160plasma lipoprotein particle clearance (GO:0034381)2.60686325
161regulation of sequestering of triglyceride (GO:0010889)2.60453206
162regulation of gonadotropin secretion (GO:0032276)2.58995831
163response to catecholamine (GO:0071869)2.58441688
164response to monoamine (GO:0071867)2.58441688
165vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.58020989
166positive regulation of Rap GTPase activity (GO:0032854)2.57643786
167positive regulation of respiratory burst (GO:0060267)2.57018970
168regulation of synapse structural plasticity (GO:0051823)2.56799144
169cardiac myofibril assembly (GO:0055003)2.55983177
170cellular response to leptin stimulus (GO:0044320)2.54530089
171regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.54399000
172negative regulation of response to food (GO:0032096)2.52998364
173negative regulation of appetite (GO:0032099)2.52998364
174glucan biosynthetic process (GO:0009250)2.51940714
175glycogen biosynthetic process (GO:0005978)2.51940714
176skeletal muscle fiber development (GO:0048741)2.51484200
177muscle contraction (GO:0006936)2.50063076
178metanephric nephron epithelium development (GO:0072243)2.47555537
179positive regulation of insulin receptor signaling pathway (GO:0046628)2.47244853
180regulation of relaxation of muscle (GO:1901077)2.46896887
181positive regulation of glycolytic process (GO:0045821)2.45701584
182phosphatidic acid biosynthetic process (GO:0006654)2.45455962
183phosphatidic acid metabolic process (GO:0046473)2.45455962
184polysaccharide catabolic process (GO:0000272)2.45033092
185triglyceride metabolic process (GO:0006641)2.44894940
186tricarboxylic acid metabolic process (GO:0072350)2.43623633

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.06299886
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.78171629
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.54615069
4GATA2_21666600_ChIP-Seq_HMVEC_Human3.84006379
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.44258728
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.43460000
7CLOCK_20551151_ChIP-Seq_293T_Human3.20108747
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.66604652
9EZH2_22144423_ChIP-Seq_EOC_Human2.49995553
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.42723716
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.42329779
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.39954788
13GATA1_22025678_ChIP-Seq_K562_Human2.37635018
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.27371894
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.22720583
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02098717
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.01877544
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.01877544
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.01720058
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.97240929
21HIF1A_21447827_ChIP-Seq_MCF-7_Human1.96821233
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.95299145
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.91742139
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90221218
25PPARA_22158963_ChIP-Seq_LIVER_Mouse1.88837437
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.87275223
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82176617
28EP300_21415370_ChIP-Seq_HL-1_Mouse1.81488168
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.80248337
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.78786834
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.76234549
32SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.73755936
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.71139859
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.70302507
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.68813310
36DROSHA_22980978_ChIP-Seq_HELA_Human1.68751303
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.67467873
38ESR1_21235772_ChIP-Seq_MCF-7_Human1.66007108
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.65279239
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.63424781
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.62967096
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.58911985
43SALL4_18804426_ChIP-ChIP_XEN_Mouse1.57583243
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.57160205
45LXR_22292898_ChIP-Seq_THP-1_Human1.56973931
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55705992
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55413369
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.55281438
49TBX20_22080862_ChIP-Seq_HEART_Mouse1.54649584
50TBX20_22328084_ChIP-Seq_HEART_Mouse1.54649584
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.53046707
52DNAJC2_21179169_ChIP-ChIP_NT2_Human1.50730103
53SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.49584777
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48351060
55CTCF_27219007_Chip-Seq_Bcells_Human1.48250648
56* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46923514
57KDM2B_26808549_Chip-Seq_K562_Human1.46347532
58SOX2_20726797_ChIP-Seq_SW620_Human1.42955151
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42285533
60IRF8_22096565_ChIP-ChIP_GC-B_Human1.42236693
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40034587
62NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.38853821
63FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38396845
64CJUN_26792858_Chip-Seq_BT549_Human1.38261454
65ESR1_20079471_ChIP-ChIP_T-47D_Human1.36806709
66BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.36587516
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35240971
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34796458
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34177964
70PPAR_26484153_Chip-Seq_NCI-H1993_Human1.32448487
71GATA1_19941826_ChIP-Seq_K562_Human1.29466584
72JARID2_20064375_ChIP-Seq_MESCs_Mouse1.28786257
73CDX2_20551321_ChIP-Seq_CACO-2_Human1.28605439
74PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.27118260
75CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.26419116
76STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.24519776
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.23267840
78ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.20746347
79RARB_27405468_Chip-Seq_BRAIN_Mouse1.19720460
80* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19601760
81EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19421392
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18235667
83SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18235667
84WT1_19549856_ChIP-ChIP_CCG9911_Human1.17900429
85NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16603892
86EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16159179
87WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16050169
88KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.14339502
89KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.14339502
90KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.14339502
91AHR_22903824_ChIP-Seq_MCF-7_Human1.13096082
92SMC3_22415368_ChIP-Seq_MEFs_Mouse1.11611489
93ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11156583
94SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10956842
95KDM2B_26808549_Chip-Seq_DND41_Human1.10946810
96NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08639789
97NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08584867
98NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08584867
99RAD21_21589869_ChIP-Seq_MESCs_Mouse1.07562888
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07214462
101BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06582936
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03489729
103SMC1_22415368_ChIP-Seq_MEFs_Mouse1.02720710
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02294148
105FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.01974116
106TET1_21490601_ChIP-Seq_MESCs_Mouse1.01852388
107FOXO3_23340844_ChIP-Seq_DLD1_Human1.01183591
108SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00951082
109* SMC4_20622854_ChIP-Seq_HELA_Human1.00734441
110ZNF263_19887448_ChIP-Seq_K562_Human1.00277356
111* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99515742
112RING1B_27294783_Chip-Seq_ESCs_Mouse0.96037980
113TP53_20018659_ChIP-ChIP_R1E_Mouse0.95181082
114CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94593061
115SA1_22415368_ChIP-Seq_MEFs_Mouse0.94185733
116PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93883518
117P68_20966046_ChIP-Seq_HELA_Human0.93234388
118NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91202142
119RUNX_20019798_ChIP-Seq_JUKART_Human0.91091839
120RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.89656642
121MYC_27129775_Chip-Seq_CORNEA_Mouse0.89486728
122SA1_27219007_Chip-Seq_Bcells_Human0.89273072
123SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88818532
124CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88806272
125FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.88022774
126UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86121185
127SOX9_24532713_ChIP-Seq_HFSC_Mouse0.85931761
128TCF4_18268006_ChIP-ChIP_LS174T_Human0.85688829
129ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.85345817
130TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84420666
131VDR_24787735_ChIP-Seq_THP-1_Human0.84263240
132KLF4_19829295_ChIP-Seq_ESCs_Human0.84141073
133PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.83365569
134SA1_27219007_Chip-Seq_ERYTHROID_Human0.83302682
135IKZF1_21737484_ChIP-ChIP_HCT116_Human0.82839647
136TP53_23651856_ChIP-Seq_MEFs_Mouse0.82215284
137STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.81978563
138SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.81913957
139OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.79559635
140BRD4_25478319_ChIP-Seq_HGPS_Human0.78896641
141RACK7_27058665_Chip-Seq_MCF-7_Human0.78820083
142EED_16625203_ChIP-ChIP_MESCs_Mouse0.78547209
143SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.77546057
144WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.77284873
145Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.76920135
146FOXA2_19822575_ChIP-Seq_HepG2_Human0.76667791
147GATA2_19941826_ChIP-Seq_K562_Human0.76187075
148CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.76058656
149TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.75745626
150RXR_22108803_ChIP-Seq_LS180_Human0.75741062
151TP53_18474530_ChIP-ChIP_U2OS_Human0.74180366
152SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.73751225
153MYB_21317192_ChIP-Seq_ERMYB_Mouse0.73093386
154UBF1/2_26484160_Chip-Seq_HMECs_Human0.73034684
155PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.72932064
156KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.72450353
157SMAD3_21741376_ChIP-Seq_HESCs_Human0.71975507
158NR3C1_23031785_ChIP-Seq_PC12_Mouse0.71565488

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage5.34821538
2MP0001879_abnormal_lymphatic_vessel5.24857070
3MP0010368_abnormal_lymphatic_system5.06646550
4MP0003724_increased_susceptibility_to4.95159831
5MP0005167_abnormal_blood-brain_barrier3.22715415
6MP0003828_pulmonary_edema3.15079838
7MP0004185_abnormal_adipocyte_glucose2.82135415
8MP0004272_abnormal_basement_membrane2.67922005
9MP0005623_abnormal_meninges_morphology2.66028885
10MP0004147_increased_porphyrin_level2.59347183
11MP0005670_abnormal_white_adipose2.49320460
12MP0000767_abnormal_smooth_muscle2.43424884
13MP0005360_urolithiasis2.41175926
14MP0005503_abnormal_tendon_morphology2.36273334
15MP0003690_abnormal_glial_cell2.32039666
16MP0003279_aneurysm2.18036604
17MP0009115_abnormal_fat_cell2.08379243
18MP0000013_abnormal_adipose_tissue2.08187876
19MP0000759_abnormal_skeletal_muscle2.00134804
20MP0005085_abnormal_gallbladder_physiolo1.98777691
21MP0003646_muscle_fatigue1.97786665
22MP0003567_abnormal_fetal_cardiomyocyte1.92394183
23MP0001851_eye_inflammation1.87504736
24MP0000747_muscle_weakness1.82947085
25MP0005084_abnormal_gallbladder_morpholo1.82428044
26MP0005535_abnormal_body_temperature1.81457433
27MP0008775_abnormal_heart_ventricle1.78073214
28MP0003705_abnormal_hypodermis_morpholog1.75480618
29MP0000249_abnormal_blood_vessel1.74749245
30MP0009780_abnormal_chondrocyte_physiolo1.74382675
31MP0002127_abnormal_cardiovascular_syste1.71477474
32MP0003191_abnormal_cellular_cholesterol1.70976028
33MP0000343_altered_response_to1.70192683
34MP0003959_abnormal_lean_body1.70058730
35MP0003252_abnormal_bile_duct1.68644009
36MP0010234_abnormal_vibrissa_follicle1.68491863
37MP0003950_abnormal_plasma_membrane1.67539814
38MP0006138_congestive_heart_failure1.67032846
39MP0002876_abnormal_thyroid_physiology1.66242281
40MP0005334_abnormal_fat_pad1.61453876
41MP0004084_abnormal_cardiac_muscle1.54896063
42MP0002638_abnormal_pupillary_reflex1.52510733
43MP0004883_abnormal_blood_vessel1.51900966
44MP0005409_darkened_coat_color1.51618208
45MP0005385_cardiovascular_system_phenoty1.51513463
46MP0001544_abnormal_cardiovascular_syste1.51513463
47MP0002138_abnormal_hepatobiliary_system1.47413146
48MP0000750_abnormal_muscle_regeneration1.45217773
49MP0002877_abnormal_melanocyte_morpholog1.39637652
50MP0002837_dystrophic_cardiac_calcinosis1.39417308
51MP0002970_abnormal_white_adipose1.39253612
52MP0005275_abnormal_skin_tensile1.38574264
53MP0003091_abnormal_cell_migration1.38130054
54MP0005187_abnormal_penis_morphology1.37002133
55MP0009697_abnormal_copulation1.36082510
56MP0005595_abnormal_vascular_smooth1.35079137
57MP0002972_abnormal_cardiac_muscle1.32692182
58MP0001501_abnormal_sleep_pattern1.32686411
59MP0005083_abnormal_biliary_tract1.32478167
60* MP0010329_abnormal_lipoprotein_level1.30126332
61MP0004130_abnormal_muscle_cell1.30033490
62MP0004036_abnormal_muscle_relaxation1.26573008
63MP0004484_altered_response_of1.24680416
64MP0005365_abnormal_bile_salt1.22203117
65MP0005164_abnormal_response_to1.21373127
66MP0010630_abnormal_cardiac_muscle1.18995850
67MP0005448_abnormal_energy_balance1.18416474
68MP0001958_emphysema1.17699457
69MP0002254_reproductive_system_inflammat1.17652050
70MP0006036_abnormal_mitochondrial_physio1.16788042
71MP0005171_absent_coat_pigmentation1.15573564
72MP0003011_delayed_dark_adaptation1.15567406
73MP0001881_abnormal_mammary_gland1.15351098
74MP0001915_intracranial_hemorrhage1.14720139
75MP0003221_abnormal_cardiomyocyte_apopto1.14121460
76MP0005330_cardiomyopathy1.13303273
77MP0002269_muscular_atrophy1.13097005
78MP0004859_abnormal_synaptic_plasticity1.12240415
79MP0002139_abnormal_hepatobiliary_system1.11825478
80MP0002128_abnormal_blood_circulation1.11796095
81MP0004215_abnormal_myocardial_fiber1.11173570
82MP0004270_analgesia1.05896053
83MP0003879_abnormal_hair_cell1.05093845
84MP0003137_abnormal_impulse_conducting1.04284712
85MP0005452_abnormal_adipose_tissue1.02924198
86MP0003045_fibrosis1.02451010
87MP0009379_abnormal_foot_pigmentation1.02409530
88MP0000749_muscle_degeneration1.02361356
89MP0002925_abnormal_cardiovascular_devel1.02177576
90MP0000003_abnormal_adipose_tissue1.02151489
91MP0001614_abnormal_blood_vessel1.01854239
92MP0005620_abnormal_muscle_contractility0.98545414
93MP0008438_abnormal_cutaneous_collagen0.96944429
94MP0005023_abnormal_wound_healing0.96816922
95MP0002909_abnormal_adrenal_gland0.96436331
96MP0000733_abnormal_muscle_development0.95283912
97MP0005666_abnormal_adipose_tissue0.94129193
98MP0002332_abnormal_exercise_endurance0.92281569
99MP0002078_abnormal_glucose_homeostasis0.91818094
100MP0004085_abnormal_heartbeat0.91355928
101MP0003566_abnormal_cell_adhesion0.90196683
102MP0005423_abnormal_somatic_nervous0.89661086
103MP0003943_abnormal_hepatobiliary_system0.89334746
104MP0003075_altered_response_to0.89090716
105MP0006276_abnormal_autonomic_nervous0.87271463
106MP0001502_abnormal_circadian_rhythm0.87089921
107MP0003868_abnormal_feces_composition0.87065850
108MP0005375_adipose_tissue_phenotype0.85563951
109MP0003948_abnormal_gas_homeostasis0.84818874
110MP0000230_abnormal_systemic_arterial0.81975395
111MP0000751_myopathy0.80802904
112MP0000516_abnormal_urinary_system0.79816385
113MP0005367_renal/urinary_system_phenotyp0.79816385
114* MP0002118_abnormal_lipid_homeostasis0.79684539
115MP0002295_abnormal_pulmonary_circulatio0.79342949
116MP0005165_increased_susceptibility_to0.79177076
117MP0009785_altered_susceptibility_to0.78931944
118MP0004087_abnormal_muscle_fiber0.78459499
119MP0008569_lethality_at_weaning0.78026239
120MP0000266_abnormal_heart_morphology0.77256880
121MP0002933_joint_inflammation0.76800157
122MP0005369_muscle_phenotype0.76060324
123MP0002971_abnormal_brown_adipose0.75826733
124MP0002108_abnormal_muscle_morphology0.75563461
125MP0003186_abnormal_redox_activity0.73784215
126MP0003448_altered_tumor_morphology0.73322111
127MP0000609_abnormal_liver_physiology0.72217049
128MP0001784_abnormal_fluid_regulation0.70686501
129MP0003635_abnormal_synaptic_transmissio0.69089482
130MP0003329_amyloid_beta_deposits0.69024258
131MP0008875_abnormal_xenobiotic_pharmacok0.68534036
132MP0002133_abnormal_respiratory_system0.68064426
133MP0005388_respiratory_system_phenotype0.68064426
134MP0003880_abnormal_central_pattern0.68019225
135MP0005584_abnormal_enzyme/coenzyme_acti0.67667593
136MP0005266_abnormal_metabolism0.66648994
137MP0002106_abnormal_muscle_physiology0.66620581
138MP0005248_abnormal_Harderian_gland0.66324066
139MP0001853_heart_inflammation0.66130793
140MP0000920_abnormal_myelination0.65882265
141MP0001661_extended_life_span0.65158295
142MP0001191_abnormal_skin_condition0.64672702
143MP0002064_seizures0.64461738
144MP0004510_myositis0.64194194
145MP0001533_abnormal_skeleton_physiology0.64151517
146MP0001486_abnormal_startle_reflex0.63850819
147MP0004145_abnormal_muscle_electrophysio0.61763136

Predicted human phenotypes

RankGene SetZ-score
1Calcaneovalgus deformity (HP:0001848)5.73924232
2Type 1 muscle fiber predominance (HP:0003803)5.27309852
3Deformed tarsal bones (HP:0008119)5.08868752
4Distal lower limb muscle weakness (HP:0009053)5.08492697
5Nonimmune hydrops fetalis (HP:0001790)4.91647469
6Oligomenorrhea (HP:0000876)4.90684089
7Increased variability in muscle fiber diameter (HP:0003557)4.82819009
8Polycythemia (HP:0001901)4.68879381
9Facial diplegia (HP:0001349)4.48932966
10Deep venous thrombosis (HP:0002625)4.43295494
11Hematochezia (HP:0002573)4.14999570
12Spontaneous hematomas (HP:0007420)4.13037330
13Abnormality of the calcaneus (HP:0008364)4.08160728
14Lymphangioma (HP:0100764)3.72476473
15Increased connective tissue (HP:0009025)3.65073059
16Distal lower limb amyotrophy (HP:0008944)3.61989620
17Esophageal varix (HP:0002040)3.44931245
18Asymmetric septal hypertrophy (HP:0001670)3.44790720
19Muscle fiber splitting (HP:0003555)3.44539435
20EMG: myopathic abnormalities (HP:0003458)3.40133209
21Muscle hypertrophy of the lower extremities (HP:0008968)3.39963193
22Autoimmune thrombocytopenia (HP:0001973)3.38045498
23Abnormality of the nasal mucosa (HP:0000433)3.28581501
24Cerebral hemorrhage (HP:0001342)3.28149149
25Frequent falls (HP:0002359)3.26931461
26Hypoalphalipoproteinemia (HP:0003233)3.21026908
27Bundle branch block (HP:0011710)3.19043344
28Atrioventricular block (HP:0001678)3.18236555
29Mesangial abnormality (HP:0001966)3.15232291
30Heart block (HP:0012722)3.12866243
31Myopathic facies (HP:0002058)3.10425361
32Abnormal atrioventricular conduction (HP:0005150)3.07539533
33Distal arthrogryposis (HP:0005684)3.06906661
34Round ear (HP:0100830)3.03063355
35Reduced subcutaneous adipose tissue (HP:0003758)3.02957934
36Lower limb amyotrophy (HP:0007210)3.01539614
37Calf muscle hypertrophy (HP:0008981)2.99388309
38Abnormality of the calf musculature (HP:0001430)2.92820473
39Segmental peripheral demyelination/remyelination (HP:0003481)2.92234056
40Subaortic stenosis (HP:0001682)2.87973090
41Abnormality of the left ventricular outflow tract (HP:0011103)2.87973090
42Conjunctival telangiectasia (HP:0000524)2.87041441
43Exercise-induced myalgia (HP:0003738)2.85954964
44Rimmed vacuoles (HP:0003805)2.84254045
45Hyporeflexia of lower limbs (HP:0002600)2.82341411
46Atrial fibrillation (HP:0005110)2.80555295
47Foot dorsiflexor weakness (HP:0009027)2.76764032
48Abnormality of the foot musculature (HP:0001436)2.74750822
49Ventricular tachycardia (HP:0004756)2.72785473
50Abnormal eating behavior (HP:0100738)2.69831306
51Sudden death (HP:0001699)2.68482052
52Lipoatrophy (HP:0100578)2.61958615
53Protrusio acetabuli (HP:0003179)2.61277009
54Subcapsular cataract (HP:0000523)2.61168799
55Supraventricular arrhythmia (HP:0005115)2.58846502
56Diaphragmatic weakness (HP:0009113)2.57661544
57Limb-girdle muscle atrophy (HP:0003797)2.57247589
58Muscle stiffness (HP:0003552)2.56045229
59Cerebral aneurysm (HP:0004944)2.52964123
60Posterior subcapsular cataract (HP:0007787)2.52184972
61Primary atrial arrhythmia (HP:0001692)2.52108239
62Toxemia of pregnancy (HP:0100603)2.51204040
63Spinal rigidity (HP:0003306)2.49729952
64Gowers sign (HP:0003391)2.48951485
65Mildly elevated creatine phosphokinase (HP:0008180)2.48799396
66Insulin resistance (HP:0000855)2.46145516
67Hypoglycemic coma (HP:0001325)2.46138082
68Exercise-induced muscle cramps (HP:0003710)2.43134673
69Ulnar deviation of the wrist (HP:0003049)2.42443608
70Acanthosis nigricans (HP:0000956)2.42421091
71Myoglobinuria (HP:0002913)2.41846991
72Hemorrhage of the eye (HP:0011885)2.41741249
73Nemaline bodies (HP:0003798)2.40620288
74Rapidly progressive (HP:0003678)2.39525931
75Intrahepatic cholestasis (HP:0001406)2.39159023
76Autoimmune hemolytic anemia (HP:0001890)2.39057538
77Supraventricular tachycardia (HP:0004755)2.37564633
78Right ventricular cardiomyopathy (HP:0011663)2.37554769
79Insulin-resistant diabetes mellitus (HP:0000831)2.37232149
80EMG: neuropathic changes (HP:0003445)2.34968138
81Broad metatarsal (HP:0001783)2.33268370
82Abnormality of the vasculature of the conjunctiva (HP:0008054)2.32695065
83Ileus (HP:0002595)2.31062016
84Abnormality of skeletal muscle fiber size (HP:0012084)2.30932452
85Neonatal death (HP:0003811)2.30215906
86Aortic aneurysm (HP:0004942)2.28440098
87Joint hemorrhage (HP:0005261)2.28398753
88Dilated cardiomyopathy (HP:0001644)2.27869261
89Stenosis of the external auditory canal (HP:0000402)2.27587249
90Prolonged partial thromboplastin time (HP:0003645)2.26090013
91Hypercortisolism (HP:0001578)2.25040048
92Rhabdomyolysis (HP:0003201)2.25034318
93Scapular winging (HP:0003691)2.24070636
94Hyperlipoproteinemia (HP:0010980)2.23929836
95Abnormality of the intrinsic pathway (HP:0010989)2.23795908
96Venous abnormality (HP:0002624)2.23445046
97Axonal loss (HP:0003447)2.23017856
98Hypolipoproteinemia (HP:0010981)2.22695279
99Pigmentary retinal degeneration (HP:0001146)2.22321648
100Myocardial infarction (HP:0001658)2.22320057
101Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.22009713
102Complement deficiency (HP:0004431)2.21779810
103Difficulty climbing stairs (HP:0003551)2.21530698
104Venous insufficiency (HP:0005293)2.20963366
105Obstructive sleep apnea (HP:0002870)2.20809290
106Visceral angiomatosis (HP:0100761)2.20791740
107Prolonged QT interval (HP:0001657)2.19977434
108Increased IgE level (HP:0003212)2.16532141
109Increased muscle lipid content (HP:0009058)2.16204630
110Mucosal telangiectasiae (HP:0100579)2.15813225
111Xanthomatosis (HP:0000991)2.11507776
112Hydroureter (HP:0000072)2.10159134
113Cavernous hemangioma (HP:0001048)2.09636129
114Abnormality of the common coagulation pathway (HP:0010990)2.08551001
115Hemangiomatosis (HP:0007461)2.08235096
116Increased mean platelet volume (HP:0011877)2.07292323
117Absent eyebrow (HP:0002223)2.06469192
118Muscle fiber inclusion bodies (HP:0100299)2.05990629
119Myotonia (HP:0002486)2.05620961
120Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.05091516
121Bulbar palsy (HP:0001283)2.03415717
122Difficulty running (HP:0009046)2.03221218
123Skin nodule (HP:0200036)2.02421545
124Neck muscle weakness (HP:0000467)2.02029614
125Malignant hyperthermia (HP:0002047)2.00197927
126Paralysis (HP:0003470)2.00169917
127Centrally nucleated skeletal muscle fibers (HP:0003687)1.99141543
128Vascular tortuosity (HP:0004948)1.98147083
129Hyperammonemia (HP:0001987)1.97563402
130Hypertriglyceridemia (HP:0002155)1.97036045
131Areflexia of lower limbs (HP:0002522)1.96101783
132Back pain (HP:0003418)1.95863117
133Cupped ribs (HP:0000887)1.94192361
134Polar cataract (HP:0010696)1.93752604
135Abnormality of binocular vision (HP:0011514)1.93613099
136Diplopia (HP:0000651)1.93613099
137Abnormality of B cell number (HP:0010975)1.93429395
138B lymphocytopenia (HP:0010976)1.93429395
139Aneurysm (HP:0002617)1.91571044
140Growth hormone excess (HP:0000845)1.91327466
141Bone cyst (HP:0012062)1.90951187
142Portal hypertension (HP:0001409)1.90834813
143Generalized muscle weakness (HP:0003324)1.90830216
144Pulmonary embolism (HP:0002204)1.90824784
145Easy fatigability (HP:0003388)1.89818313
146Respiratory insufficiency due to muscle weakness (HP:0002747)1.89309028
147Hyperkalemia (HP:0002153)1.88591348
148Short nail (HP:0001799)1.87560017
149Abnormality of complement system (HP:0005339)1.82782506
150Stridor (HP:0010307)1.78347775
151Ventricular arrhythmia (HP:0004308)1.77444149
152Action tremor (HP:0002345)1.76134645
153Steppage gait (HP:0003376)1.74230647
154Abnormality of the periventricular white matter (HP:0002518)1.74190613
155Ankle clonus (HP:0011448)1.73471665
156Abnormal EKG (HP:0003115)1.73109031

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE17.47998028
2PDK25.00344947
3KDR4.49765195
4TGFBR24.09651399
5TGFBR13.91497361
6RIPK12.88448655
7MAP3K142.84677062
8LATS22.78171355
9EPHB22.70476732
10AKT32.60354080
11MAPK122.17134265
12TSSK62.06963616
13ERN11.94434807
14MYLK1.79240419
15MAPK71.77562143
16MARK11.70076062
17PTK61.66556651
18PINK11.66307723
19DDR21.58246587
20EPHB11.56703327
21PRKD31.54440759
22GRK51.52178396
23FER1.48921754
24PTK2B1.48828019
25TESK11.40389784
26EEF2K1.37357984
27MAP3K131.35960669
28TTN1.32559714
29DAPK21.32283257
30MAPKAPK31.29159394
31ARAF1.28575253
32PHKG11.27936422
33PHKG21.27936422
34FGFR41.26771435
35NEK61.22319962
36NTRK31.21863988
37UHMK11.16945543
38TBK11.15187263
39MAP3K31.10344939
40MOS1.10320802
41IKBKE1.08786411
42MAP2K31.06633644
43PAK61.04681563
44DMPK1.04463501
45MAP3K71.04151291
46INSRR1.04002222
47EPHA41.01868629
48CAMK2G0.96047012
49PDK40.95863703
50PDK30.95863703
51MARK20.95718818
52PRKCH0.94992426
53CAMKK20.89870522
54LATS10.89789717
55NEK90.89588540
56ABL20.89181725
57FGFR30.85245261
58KSR20.84546099
59CAMK2B0.84173179
60CAMKK10.84053678
61RIPK40.83878011
62MAP3K60.79943438
63EPHA20.77191593
64CSK0.76324002
65PAK40.74745911
66SGK4940.73285823
67SGK2230.73285823
68PRKD10.72720534
69PRKG10.71635602
70CDK50.70479067
71MUSK0.69431780
72CAMK2D0.67658768
73MAP2K40.66582374
74MAP3K90.64103640
75PIK3CG0.63072596
76NTRK10.62162456
77GSK3A0.61217112
78PKN20.60914425
79MARK30.60752230
80EIF2AK20.60253865
81BMPR1B0.60041067
82CDC42BPA0.59834038
83JAK30.57296238
84ROCK10.55242215
85CLK10.55186787
86EPHA30.55145203
87DAPK30.55023671
88PRKACG0.54159543
89PDK10.53675808
90MAP3K10.53600547
91RPS6KA30.53483220
92CHUK0.53473853
93NTRK20.52624421
94PKN10.52320823
95JAK10.51734018
96CAMK2A0.51520000
97MAPK100.49903736
98LMTK20.49059299
99ERBB30.47915900
100MAP2K10.47596087
101STK380.47497429
102BCKDK0.46514736
103CSNK1A1L0.45803135
104PDPK10.44060963
105ROCK20.42944971
106PTK20.42136382
107MAP3K110.41790025
108BCR0.41734873
109OBSCN0.41720837
110ICK0.41019563
111STK110.40915208
112GRK10.40616023
113PIM20.40492489
114PRPF4B0.39275767
115PDGFRB0.38818227
116PRKACA0.38051165
117IGF1R0.37904226
118CAMK10.37367224
119SGK10.36832682
120TYK20.36749909
121PDGFRA0.36521739
122MAPK150.35483458
123MAPK40.33790755
124NLK0.33754285
125EGFR0.33089743
126FRK0.32429361
127MAP2K20.31977647
128PRKAA20.30542486
129FES0.29278995
130NUAK10.28963735
131PAK20.28758475
132TRPM70.26336947
133CAMK40.25362004
134FGFR20.24962122
135MST1R0.24905049
136PRKCE0.24261250
137PRKCQ0.24151792
138MAPKAPK50.24039420
139ABL10.23870039
140RET0.21331245
141PRKCD0.19093335
142JAK20.18677225
143SGK30.17512637
144TEC0.17394153
145CDK90.16210500
146SGK20.16027816
147SRC0.15248603
148PRKAA10.15071833
149INSR0.14875793
150CDK60.14711544
151SIK10.14597606
152AKT20.14124739
153TRIB30.13975457

Predicted pathways (KEGG)

RankGene SetZ-score
1Malaria_Homo sapiens_hsa051442.97468042
2Staphylococcus aureus infection_Homo sapiens_hsa051502.73843253
3Phenylalanine metabolism_Homo sapiens_hsa003602.58694889
4African trypanosomiasis_Homo sapiens_hsa051432.50955735
5Complement and coagulation cascades_Homo sapiens_hsa046102.38413337
6Fatty acid degradation_Homo sapiens_hsa000712.31977799
7PPAR signaling pathway_Homo sapiens_hsa033202.23863108
8Propanoate metabolism_Homo sapiens_hsa006402.06191569
9Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.96495795
10Primary bile acid biosynthesis_Homo sapiens_hsa001201.90699192
11Leukocyte transendothelial migration_Homo sapiens_hsa046701.89454465
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86327078
13Tryptophan metabolism_Homo sapiens_hsa003801.79497951
14Fatty acid metabolism_Homo sapiens_hsa012121.75977681
15Renin secretion_Homo sapiens_hsa049241.75446097
16Dilated cardiomyopathy_Homo sapiens_hsa054141.69653525
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.65623919
18Nitrogen metabolism_Homo sapiens_hsa009101.62178243
19Viral myocarditis_Homo sapiens_hsa054161.58857619
20Arginine biosynthesis_Homo sapiens_hsa002201.58827947
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.55794146
22Vitamin digestion and absorption_Homo sapiens_hsa049771.54750862
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.51962952
24Adherens junction_Homo sapiens_hsa045201.44506003
25Fat digestion and absorption_Homo sapiens_hsa049751.43301281
26Long-term potentiation_Homo sapiens_hsa047201.43021061
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.40338039
28Tyrosine metabolism_Homo sapiens_hsa003501.38514421
29Bile secretion_Homo sapiens_hsa049761.35275757
30Circadian rhythm_Homo sapiens_hsa047101.33558227
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32579225
32Focal adhesion_Homo sapiens_hsa045101.31777818
33Vascular smooth muscle contraction_Homo sapiens_hsa042701.30920796
34Insulin signaling pathway_Homo sapiens_hsa049101.29979777
35Adipocytokine signaling pathway_Homo sapiens_hsa049201.29926513
36Oxytocin signaling pathway_Homo sapiens_hsa049211.25653499
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.20409819
38TNF signaling pathway_Homo sapiens_hsa046681.19033481
39Caffeine metabolism_Homo sapiens_hsa002321.16416705
40Circadian entrainment_Homo sapiens_hsa047131.16235126
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.14906712
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14799376
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.14544255
44Insulin resistance_Homo sapiens_hsa049311.14207138
45Gastric acid secretion_Homo sapiens_hsa049711.12177362
46Morphine addiction_Homo sapiens_hsa050321.07983080
47cAMP signaling pathway_Homo sapiens_hsa040241.05658576
48Amphetamine addiction_Homo sapiens_hsa050311.04909485
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04556537
50Phospholipase D signaling pathway_Homo sapiens_hsa040721.03494908
51Calcium signaling pathway_Homo sapiens_hsa040201.01774418
52ECM-receptor interaction_Homo sapiens_hsa045121.01495534
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01048404
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.00858007
55Insulin secretion_Homo sapiens_hsa049110.99824968
56Fatty acid elongation_Homo sapiens_hsa000620.96082384
57GABAergic synapse_Homo sapiens_hsa047270.95523636
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94176385
59Rap1 signaling pathway_Homo sapiens_hsa040150.92684693
60GnRH signaling pathway_Homo sapiens_hsa049120.91715136
61Tight junction_Homo sapiens_hsa045300.90565452
62Hepatitis C_Homo sapiens_hsa051600.89082017
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88315423
64ABC transporters_Homo sapiens_hsa020100.88007328
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87918703
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87722273
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85632522
68Glutamatergic synapse_Homo sapiens_hsa047240.84547606
69Thyroid cancer_Homo sapiens_hsa052160.83622250
70Fatty acid biosynthesis_Homo sapiens_hsa000610.82222813
71Butanoate metabolism_Homo sapiens_hsa006500.81892673
72Starch and sucrose metabolism_Homo sapiens_hsa005000.80191312
73Pyruvate metabolism_Homo sapiens_hsa006200.80016020
74Cocaine addiction_Homo sapiens_hsa050300.79167759
75Peroxisome_Homo sapiens_hsa041460.78695897
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78083871
77Ovarian steroidogenesis_Homo sapiens_hsa049130.77933639
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75725950
79Hematopoietic cell lineage_Homo sapiens_hsa046400.75420688
80Salivary secretion_Homo sapiens_hsa049700.73828607
81beta-Alanine metabolism_Homo sapiens_hsa004100.70902566
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70651043
83Estrogen signaling pathway_Homo sapiens_hsa049150.69387572
84Histidine metabolism_Homo sapiens_hsa003400.69281348
85Platelet activation_Homo sapiens_hsa046110.68631718
86Proteoglycans in cancer_Homo sapiens_hsa052050.68416193
87Toxoplasmosis_Homo sapiens_hsa051450.67911207
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.67413000
89PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67211639
90TGF-beta signaling pathway_Homo sapiens_hsa043500.66828783
91Dorso-ventral axis formation_Homo sapiens_hsa043200.65532871
92Synaptic vesicle cycle_Homo sapiens_hsa047210.64492382
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.64090133
94Cholinergic synapse_Homo sapiens_hsa047250.62048817
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60885561
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60054876
97Carbon metabolism_Homo sapiens_hsa012000.59562222
98Influenza A_Homo sapiens_hsa051640.59329529
99Dopaminergic synapse_Homo sapiens_hsa047280.58000959
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56135431
101Cardiac muscle contraction_Homo sapiens_hsa042600.55829846
102Salmonella infection_Homo sapiens_hsa051320.55822557
103Nicotine addiction_Homo sapiens_hsa050330.55096405
104Retinol metabolism_Homo sapiens_hsa008300.53395063
105Gap junction_Homo sapiens_hsa045400.52331235
106Glycosaminoglycan degradation_Homo sapiens_hsa005310.52306796
107Legionellosis_Homo sapiens_hsa051340.52214621
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51836023
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51715518
110AMPK signaling pathway_Homo sapiens_hsa041520.49915105
111Notch signaling pathway_Homo sapiens_hsa043300.49615075
112Prion diseases_Homo sapiens_hsa050200.49522644
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49178192
114Melanogenesis_Homo sapiens_hsa049160.48573348
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.48294755
116Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46661381
117Amoebiasis_Homo sapiens_hsa051460.46651495
118Sulfur relay system_Homo sapiens_hsa041220.46343275
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45328810
120Axon guidance_Homo sapiens_hsa043600.44769118
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44442958
122Galactose metabolism_Homo sapiens_hsa000520.44326864
123Shigellosis_Homo sapiens_hsa051310.43759753
124Pertussis_Homo sapiens_hsa051330.43508534
125HIF-1 signaling pathway_Homo sapiens_hsa040660.43399657
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43388160
127Prostate cancer_Homo sapiens_hsa052150.43348724
128VEGF signaling pathway_Homo sapiens_hsa043700.42424001
129Type II diabetes mellitus_Homo sapiens_hsa049300.42280001
130MAPK signaling pathway_Homo sapiens_hsa040100.42097418
131Osteoclast differentiation_Homo sapiens_hsa043800.42050254
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41909174
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41069825
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.40075965
135Chemical carcinogenesis_Homo sapiens_hsa052040.40031399
136Glucagon signaling pathway_Homo sapiens_hsa049220.39956830
137Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39781637
138Ras signaling pathway_Homo sapiens_hsa040140.39688705
139Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38530017
140Pancreatic secretion_Homo sapiens_hsa049720.38474455
141Glycerolipid metabolism_Homo sapiens_hsa005610.37971986
142Arginine and proline metabolism_Homo sapiens_hsa003300.37384451
143Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37268216
144Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36022262
145Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35523867
146Glioma_Homo sapiens_hsa052140.35243782

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