GPI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* glycolytic process (GO:0006096)5.22426108
2regulation of translational fidelity (GO:0006450)4.73266716
3* gluconeogenesis (GO:0006094)4.52744051
4DNA unwinding involved in DNA replication (GO:0006268)4.43186986
5Golgi transport vesicle coating (GO:0048200)4.31628701
6COPI coating of Golgi vesicle (GO:0048205)4.31628701
7* hexose biosynthetic process (GO:0019319)4.20926156
8* monosaccharide biosynthetic process (GO:0046364)4.12308872
9proline biosynthetic process (GO:0006561)4.01679670
10mitotic chromosome condensation (GO:0007076)3.93050630
11tricarboxylic acid cycle (GO:0006099)3.91827797
12mitotic sister chromatid segregation (GO:0000070)3.80414444
13* pyruvate metabolic process (GO:0006090)3.72534137
14DNA strand elongation involved in DNA replication (GO:0006271)3.65558592
15nuclear pore complex assembly (GO:0051292)3.64353601
16pentose-phosphate shunt (GO:0006098)3.62663328
17L-serine metabolic process (GO:0006563)3.57159654
18NADPH regeneration (GO:0006740)3.55364161
19formation of translation preinitiation complex (GO:0001731)3.53592652
20DNA strand elongation (GO:0022616)3.51558761
21NADH metabolic process (GO:0006734)3.46146732
22sister chromatid segregation (GO:0000819)3.43317874
23retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.30830938
24synaptic vesicle docking involved in exocytosis (GO:0016081)3.28311572
25tRNA aminoacylation for protein translation (GO:0006418)3.25996677
264-hydroxyproline metabolic process (GO:0019471)3.23410203
27peptidyl-arginine omega-N-methylation (GO:0035247)3.22676018
28nucleobase-containing small molecule interconversion (GO:0015949)3.21821075
29oxaloacetate metabolic process (GO:0006107)3.21293438
30nuclear pore organization (GO:0006999)3.21110022
31protein maturation by protein folding (GO:0022417)3.20333428
32glucose catabolic process (GO:0006007)3.20323282
33fructose metabolic process (GO:0006000)3.18029796
34amino acid activation (GO:0043038)3.13512776
35tRNA aminoacylation (GO:0043039)3.13512776
36IMP biosynthetic process (GO:0006188)3.12827527
37DNA replication initiation (GO:0006270)3.11592761
38peptidyl-proline hydroxylation (GO:0019511)3.09871334
39protein complex localization (GO:0031503)3.05980921
40folic acid-containing compound biosynthetic process (GO:0009396)3.05774793
41mitotic nuclear envelope disassembly (GO:0007077)3.05525844
42regulation of translational elongation (GO:0006448)3.02341910
43telomere maintenance via semi-conservative replication (GO:0032201)3.02061787
44regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.01630452
45sodium ion export (GO:0071436)2.98121367
46regulation of mitotic spindle organization (GO:0060236)2.94876912
47synaptic vesicle maturation (GO:0016188)2.92184171
48nuclear envelope disassembly (GO:0051081)2.89683276
49membrane disassembly (GO:0030397)2.89683276
50establishment of integrated proviral latency (GO:0075713)2.89020575
51IMP metabolic process (GO:0046040)2.87420684
52spliceosomal tri-snRNP complex assembly (GO:0000244)2.83281685
53* glucose 6-phosphate metabolic process (GO:0051156)2.81150634
54proline metabolic process (GO:0006560)2.80926309
55regulation of cofactor metabolic process (GO:0051193)2.77808561
56regulation of coenzyme metabolic process (GO:0051196)2.77808561
57glutamate secretion (GO:0014047)2.75984793
58maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.73390434
59pore complex assembly (GO:0046931)2.72591530
60nucleobase biosynthetic process (GO:0046112)2.71247953
61protein retention in ER lumen (GO:0006621)2.70091573
62protein hydroxylation (GO:0018126)2.69460683
63melanin biosynthetic process (GO:0042438)2.68032500
64peptidyl-arginine N-methylation (GO:0035246)2.67862895
65peptidyl-arginine methylation (GO:0018216)2.67862895
66positive regulation of DNA-dependent DNA replication (GO:2000105)2.66787641
67mitotic nuclear envelope reassembly (GO:0007084)2.65518646
68nuclear envelope reassembly (GO:0031468)2.65518646
69purine nucleobase biosynthetic process (GO:0009113)2.64402684
70histone arginine methylation (GO:0034969)2.61896782
71serine family amino acid biosynthetic process (GO:0009070)2.61380418
72pteridine-containing compound biosynthetic process (GO:0042559)2.58032734
73glutamine metabolic process (GO:0006541)2.56831878
74regulation of short-term neuronal synaptic plasticity (GO:0048172)2.55817162
75chromosome condensation (GO:0030261)2.54241957
76cellular protein complex localization (GO:0034629)2.53515023
77regulation of spindle organization (GO:0090224)2.52831701
78regulation of translational termination (GO:0006449)2.52825675
79protein export from nucleus (GO:0006611)2.50559888
80nuclear envelope organization (GO:0006998)2.50531940
81tetrahydrofolate metabolic process (GO:0046653)2.48209820
82mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.45035014
83* glucose metabolic process (GO:0006006)2.44993720
84regulation of mammary gland epithelial cell proliferation (GO:0033599)2.44754679
85oxidative phosphorylation (GO:0006119)2.44599658
86cytoskeletal anchoring at plasma membrane (GO:0007016)2.43880261
87mitotic sister chromatid cohesion (GO:0007064)2.43667087
88negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.42928641
89ribosome assembly (GO:0042255)2.40960368
90tricarboxylic acid metabolic process (GO:0072350)2.40320515
91synaptic vesicle exocytosis (GO:0016079)2.38646394
92* single-organism carbohydrate catabolic process (GO:0044724)2.38380737
93DNA replication checkpoint (GO:0000076)2.36966773
94negative regulation of microtubule polymerization (GO:0031115)2.36375565
95layer formation in cerebral cortex (GO:0021819)2.36065864
96biotin metabolic process (GO:0006768)2.35563210
97negative regulation of cell size (GO:0045792)2.34731244
98melanin metabolic process (GO:0006582)2.34365681
99DNA duplex unwinding (GO:0032508)2.32414117
100mitotic G1 DNA damage checkpoint (GO:0031571)2.31985335

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.18538932
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.73064184
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.41698514
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.23414696
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.13160209
6MYC_18358816_ChIP-ChIP_MESCs_Mouse2.48994275
7THAP11_20581084_ChIP-Seq_MESCs_Mouse2.48801804
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.46569526
9ZNF263_19887448_ChIP-Seq_K562_Human2.38989185
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.38696032
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.36069038
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.28812464
13* HIF1A_21447827_ChIP-Seq_MCF-7_Human2.27003096
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.21770522
15AR_21909140_ChIP-Seq_LNCAP_Human2.21462091
16XRN2_22483619_ChIP-Seq_HELA_Human2.21296804
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.13868772
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12393488
19CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.11754230
20CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.04498077
21ZFX_18555785_ChIP-Seq_MESCs_Mouse2.02260798
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.01431744
23MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89158292
24ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.87747900
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.87483186
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.83469526
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.83326196
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.82985297
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81103491
30DCP1A_22483619_ChIP-Seq_HELA_Human1.78848531
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.75970772
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73117906
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.71591886
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69378079
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.67094584
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.66815951
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66723024
38* MYC_22102868_ChIP-Seq_BL_Human1.63946328
39CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.63535355
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.62943552
41KLF4_18555785_ChIP-Seq_MESCs_Mouse1.60398717
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57187041
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53874167
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52892349
45* GABP_19822575_ChIP-Seq_HepG2_Human1.52613812
46KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52565997
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.50881734
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.47112296
49PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.47065113
50TTF2_22483619_ChIP-Seq_HELA_Human1.46230364
51CLOCK_20551151_ChIP-Seq_293T_Human1.45605557
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43856605
53* LXR_22292898_ChIP-Seq_THP-1_Human1.41699651
54SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.40677720
55KDM5A_27292631_Chip-Seq_BREAST_Human1.40177336
56* RACK7_27058665_Chip-Seq_MCF-7_Human1.38505168
57DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36736319
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35345346
59HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.30800885
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30625542
61TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29337957
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28616048
63CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.27006734
64EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26252716
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25309946
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23908629
67SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.23140115
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18577428
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16794892
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16280654
71CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15208293
72NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15012829
73TET1_21451524_ChIP-Seq_MESCs_Mouse1.13145727
74PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10939606
75TBX5_21415370_ChIP-Seq_HL-1_Mouse1.10384446
76RARB_27405468_Chip-Seq_BRAIN_Mouse1.08088465
77BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06816629
78CHD1_26751641_Chip-Seq_LNCaP_Human1.04619236
79TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.04090956
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03776995
81SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03697156
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03380256
83EGR1_19374776_ChIP-ChIP_THP-1_Human1.03315877
84EST1_17652178_ChIP-ChIP_JURKAT_Human1.03132063
85SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02869915
86NANOG_21062744_ChIP-ChIP_HESCs_Human1.01202954
87ATF3_27146783_Chip-Seq_COLON_Human1.00937405
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00619985
89TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00199676
90ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97829800
91TP63_17297297_ChIP-ChIP_HaCaT_Human0.97369872
92P68_20966046_ChIP-Seq_HELA_Human0.96041963
93SRF_21415370_ChIP-Seq_HL-1_Mouse0.95692313
94* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95306639
95FOXP1_21924763_ChIP-Seq_HESCs_Human0.94255490
96P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93907047
97TFEB_21752829_ChIP-Seq_HELA_Human0.93414969
98GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.92916582
99KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92498404
100SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92437582

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.11815305
2MP0003111_abnormal_nucleus_morphology3.02038054
3MP0010234_abnormal_vibrissa_follicle3.00612732
4MP0004859_abnormal_synaptic_plasticity2.80487370
5MP0003693_abnormal_embryo_hatching2.70141817
6MP0002877_abnormal_melanocyte_morpholog2.64288213
7MP0004233_abnormal_muscle_weight2.61161183
8MP0004270_analgesia2.27757612
9MP0003077_abnormal_cell_cycle2.26682773
10MP0004957_abnormal_blastocyst_morpholog2.19032100
11MP0005171_absent_coat_pigmentation2.18403579
12MP0003123_paternal_imprinting2.14700601
13MP0008932_abnormal_embryonic_tissue2.09930052
14MP0000372_irregular_coat_pigmentation2.06494941
15MP0005451_abnormal_body_composition1.86554072
16MP0000751_myopathy1.76040976
17MP0008057_abnormal_DNA_replication1.65181290
18MP0001730_embryonic_growth_arrest1.64827452
19MP0000747_muscle_weakness1.63210840
20MP0008058_abnormal_DNA_repair1.62860027
21MP0008007_abnormal_cellular_replicative1.61955503
22MP0005257_abnormal_intraocular_pressure1.55711712
23MP0005408_hypopigmentation1.48632176
24MP0009672_abnormal_birth_weight1.48484961
25MP0003705_abnormal_hypodermis_morpholog1.37065283
26MP0005623_abnormal_meninges_morphology1.35902681
27MP0000350_abnormal_cell_proliferation1.34684234
28MP0000537_abnormal_urethra_morphology1.30744397
29MP0001661_extended_life_span1.25819398
30MP0002080_prenatal_lethality1.25664280
31MP0000003_abnormal_adipose_tissue1.25144857
32MP0005330_cardiomyopathy1.23554063
33MP0009046_muscle_twitch1.23131026
34MP0001697_abnormal_embryo_size1.16734953
35MP0003880_abnormal_central_pattern1.16251560
36MP0006036_abnormal_mitochondrial_physio1.16005564
37MP0000749_muscle_degeneration1.15709909
38MP0002269_muscular_atrophy1.15463464
39MP0000678_abnormal_parathyroid_gland1.13073246
40MP0001348_abnormal_lacrimal_gland1.12443397
41MP0000358_abnormal_cell_content/1.11149643
42MP0001672_abnormal_embryogenesis/_devel1.10889068
43MP0005380_embryogenesis_phenotype1.10889068
44MP0004087_abnormal_muscle_fiber1.10198330
45MP0001346_abnormal_lacrimal_gland1.09953220
46MP0000579_abnormal_nail_morphology1.09194642
47MP0005645_abnormal_hypothalamus_physiol1.08090614
48MP0004185_abnormal_adipocyte_glucose1.07895594
49MP0003786_premature_aging1.07870430
50MP0003635_abnormal_synaptic_transmissio1.07401143
51MP0002938_white_spotting1.05352701
52MP0002822_catalepsy1.03355102
53MP0008569_lethality_at_weaning1.01681372
54MP0006035_abnormal_mitochondrial_morpho0.99589653
55MP0001529_abnormal_vocalization0.99585728
56MP0003984_embryonic_growth_retardation0.99504756
57MP0002064_seizures0.98398100
58MP0002063_abnormal_learning/memory/cond0.97216057
59MP0005076_abnormal_cell_differentiation0.96235152
60MP0002088_abnormal_embryonic_growth/wei0.93242163
61MP0001849_ear_inflammation0.92301591
62MP0005666_abnormal_adipose_tissue0.92267626
63MP0005423_abnormal_somatic_nervous0.92219245
64MP0000015_abnormal_ear_pigmentation0.91746203
65MP0003221_abnormal_cardiomyocyte_apopto0.89736899
66MP0004811_abnormal_neuron_physiology0.89102774
67MP0003806_abnormal_nucleotide_metabolis0.88918762
68MP0009780_abnormal_chondrocyte_physiolo0.88287775
69MP0002075_abnormal_coat/hair_pigmentati0.87129547
70MP0005670_abnormal_white_adipose0.87008207
71MP0003122_maternal_imprinting0.85723026
72MP0000566_synostosis0.85583280
73MP0005375_adipose_tissue_phenotype0.85152319
74MP0000759_abnormal_skeletal_muscle0.83867194
75MP0008260_abnormal_autophagy0.83797649
76MP0003315_abnormal_perineum_morphology0.83685713
77MP0004858_abnormal_nervous_system0.83486549
78MP0002085_abnormal_embryonic_tissue0.83280908
79MP0010630_abnormal_cardiac_muscle0.82853784
80MP0010030_abnormal_orbit_morphology0.82667276
81MP0000750_abnormal_muscle_regeneration0.82439874
82MP0002090_abnormal_vision0.80457917
83MP0003329_amyloid_beta_deposits0.80384532
84MP0001186_pigmentation_phenotype0.79456171
85MP0000313_abnormal_cell_death0.77062110
86MP0005384_cellular_phenotype0.76395138
87MP0004197_abnormal_fetal_growth/weight/0.75173852
88MP0002734_abnormal_mechanical_nocicepti0.74164816
89MP0010352_gastrointestinal_tract_polyps0.72867841
90MP0004272_abnormal_basement_membrane0.71021507
91MP0002249_abnormal_larynx_morphology0.69954637
92MP0004381_abnormal_hair_follicle0.68518322
93MP0005187_abnormal_penis_morphology0.68287313
94MP0002084_abnormal_developmental_patter0.67824044
95MP0002106_abnormal_muscle_physiology0.66269579
96MP0003566_abnormal_cell_adhesion0.65688660
97MP0002184_abnormal_innervation0.65021122
98MP0002086_abnormal_extraembryonic_tissu0.64912164
99MP0009745_abnormal_behavioral_response0.64885632
100MP0002066_abnormal_motor_capabilities/c0.64555308

Predicted human phenotypes

RankGene SetZ-score
1* Abnormal gallbladder physiology (HP:0012438)6.01029789
2* Cholecystitis (HP:0001082)6.01029789
3Increased serum pyruvate (HP:0003542)4.28432753
4* Abnormality of glycolysis (HP:0004366)4.28432753
5Exercise-induced muscle cramps (HP:0003710)3.32628433
6Hyperacusis (HP:0010780)3.24558341
7Insomnia (HP:0100785)3.08104018
8* Cholelithiasis (HP:0001081)2.90504761
9Reticulocytosis (HP:0001923)2.78102460
10Myoglobinuria (HP:0002913)2.75369883
11Increased nuchal translucency (HP:0010880)2.75198370
12Chromosomal breakage induced by crosslinking agents (HP:0003221)2.64068809
13* Abnormal gallbladder morphology (HP:0012437)2.59198960
14Chromsome breakage (HP:0040012)2.53065991
15Microvesicular hepatic steatosis (HP:0001414)2.46613024
16Rhabdomyolysis (HP:0003201)2.44758364
17Hypokinesia (HP:0002375)2.43592083
18Ragged-red muscle fibers (HP:0003200)2.34572657
19Distal upper limb amyotrophy (HP:0007149)2.34194487
20Upper limb amyotrophy (HP:0009129)2.34194487
21* Abnormality of the gallbladder (HP:0005264)2.33250048
22Dysmetric saccades (HP:0000641)2.32447222
23Multiple enchondromatosis (HP:0005701)2.29121003
24Cerebral hypomyelination (HP:0006808)2.22666873
25Hypoplasia of the capital femoral epiphysis (HP:0003090)2.20578306
26Hand muscle atrophy (HP:0009130)2.18983215
27Myokymia (HP:0002411)2.18871339
28Septate vagina (HP:0001153)2.18344884
29Abnormality of reticulocytes (HP:0004312)2.14147645
30Birth length less than 3rd percentile (HP:0003561)2.04296358
31Upper limb muscle weakness (HP:0003484)2.04102169
32Pointed chin (HP:0000307)1.98479674
33Elfin facies (HP:0004428)1.97320664
34Ependymoma (HP:0002888)1.94065954
35Overriding aorta (HP:0002623)1.93795745
36Exercise-induced myalgia (HP:0003738)1.93507525
37Distal lower limb amyotrophy (HP:0008944)1.93261757
38Testicular atrophy (HP:0000029)1.92884346
39Progressive muscle weakness (HP:0003323)1.91382216
40Abnormality of the astrocytes (HP:0100707)1.90065017
41Astrocytoma (HP:0009592)1.90065017
42Lower limb amyotrophy (HP:0007210)1.88602378
43Centrally nucleated skeletal muscle fibers (HP:0003687)1.87912636
44Termporal pattern (HP:0011008)1.86941650
45Insidious onset (HP:0003587)1.86941650
46Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.86521554
47Myopathic facies (HP:0002058)1.85704340
48Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.85585658
49Absent epiphyses (HP:0010577)1.85585658
50Hammertoe (HP:0001765)1.84900933
51Distal sensory impairment (HP:0002936)1.79427148
52Gout (HP:0001997)1.75173596
53Long palpebral fissure (HP:0000637)1.73994011
54Pheochromocytoma (HP:0002666)1.73697867
55Impaired pain sensation (HP:0007328)1.72634482
56Abnormality of pain sensation (HP:0010832)1.72634482
57Microglossia (HP:0000171)1.70624871
58Proximal placement of thumb (HP:0009623)1.69935331
59Heterochromia iridis (HP:0001100)1.69925296
60Ankle clonus (HP:0011448)1.65736815
61Trismus (HP:0000211)1.64510553
62Cortical dysplasia (HP:0002539)1.64332115
63Progressive external ophthalmoplegia (HP:0000590)1.63692254
64Truncus arteriosus (HP:0001660)1.63539070
65Abnormality of the anterior horn cell (HP:0006802)1.62987294
66Degeneration of anterior horn cells (HP:0002398)1.62987294
67Deviation of the thumb (HP:0009603)1.62781414
68Orthostatic hypotension (HP:0001278)1.62352464
69Depression (HP:0000716)1.62320881
70Muscle stiffness (HP:0003552)1.60964149
71CNS hypomyelination (HP:0003429)1.60691623
72High anterior hairline (HP:0009890)1.60313871
73Postnatal microcephaly (HP:0005484)1.60247601
74Hypopigmentation of the fundus (HP:0007894)1.57838776
75Achilles tendon contracture (HP:0001771)1.56113835
76Diminished movement (HP:0002374)1.54961121
77Abnormality of cochlea (HP:0000375)1.54407330
78Stridor (HP:0010307)1.52739357
79Overlapping toe (HP:0001845)1.50327343
80Foot dorsiflexor weakness (HP:0009027)1.50062160
81Precocious puberty (HP:0000826)1.49994668
82Renal duplication (HP:0000075)1.49360606
83Athetosis (HP:0002305)1.48300282
84Neonatal death (HP:0003811)1.47424101
85Exercise intolerance (HP:0003546)1.46795960
86Macroorchidism (HP:0000053)1.45901114
87Supranuclear gaze palsy (HP:0000605)1.45142158
88Annular pancreas (HP:0001734)1.44538535
89Cafe-au-lait spot (HP:0000957)1.44494762
90Nuclear cataract (HP:0100018)1.43834916
91Asymmetry of the thorax (HP:0001555)1.43598612
92Progressive hearing impairment (HP:0001730)1.43497336
93Tetraplegia (HP:0002445)1.43197503
94Abnormality of the Achilles tendon (HP:0005109)1.42640502
95Glossoptosis (HP:0000162)1.42285834
96Visual hallucinations (HP:0002367)1.41861076
97Pterygium (HP:0001059)1.41110852
98Adducted thumb (HP:0001181)1.41077144
99Abnormal cartilage morphology (HP:0002763)1.40155460
100Back pain (HP:0003418)1.39723757

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.56233253
2NEK13.49257384
3PKN23.27178821
4TRIB33.21467243
5SMG13.07392853
6BUB13.05161631
7EIF2AK12.55025398
8ICK2.50602743
9PRKD32.25941837
10NME22.22359920
11TSSK62.20341028
12TTK1.82641027
13CDC71.78717155
14ARAF1.70222761
15MAP3K91.69267163
16PAK61.68930738
17WEE11.63234655
18BRSK11.63194715
19CDK121.58546358
20PDK21.55693120
21VRK21.48535527
22IRAK31.48224789
23MST1R1.43308390
24SRPK11.27850792
25PBK1.27507632
26KSR21.25014129
27SCYL21.24551274
28PHKG11.20435638
29PHKG21.20435638
30LATS21.20195920
31LMTK21.20019430
32SIK11.18583871
33DAPK11.15994461
34BCKDK1.09376801
35EPHA21.03011699
36BRAF1.01777934
37RPS6KB21.00723075
38PLK30.99536142
39FLT30.96915644
40AKT20.96158703
41CDK180.95030113
42EPHA40.93696216
43ALK0.93677622
44PAK40.93126783
45CDK150.92649704
46NTRK10.91252221
47CDK70.91055469
48CDK11A0.88481640
49MAPKAPK50.88300586
50MARK10.87617386
51NME10.87235757
52ATR0.85081930
53MINK10.83996282
54MAP3K80.83745925
55PLK20.81615794
56CDK140.80533115
57CHEK10.80316436
58CHEK20.77804533
59CCNB10.77160322
60AURKA0.76375127
61TESK10.74732479
62MTOR0.72342183
63TTN0.70629943
64RAF10.70299058
65MAPKAPK30.69343527
66PLK10.69149287
67SIK30.64740184
68PTK20.64503907
69TRIM280.63593911
70EIF2AK30.63551779
71FGFR40.63542644
72PRPF4B0.63030346
73MAPK110.62010207
74LIMK10.60785732
75AURKB0.59108248
76CDK10.58347654
77FGFR10.57007850
78PRKCI0.56016506
79NEK20.53590683
80UHMK10.53198659
81FER0.52063713
82SIK20.51877338
83PAK10.50970737
84CDK20.49723870
85KSR10.49240693
86MET0.48565193
87CAMK1D0.46308412
88NEK60.46123507
89CAMK2B0.46066219
90NTRK30.45078442
91CSNK1G30.44827213
92CDK80.44353693
93CSNK1A1L0.42545320
94TAF10.42477105
95ILK0.42182745
96PIM20.40604894
97PRKAA10.40517671
98CAMK2G0.38436007
99ATM0.38283401
100EIF2AK20.36785448

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.52416947
2Biosynthesis of amino acids_Homo sapiens_hsa012303.46799981
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.35361652
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.84949297
5Fructose and mannose metabolism_Homo sapiens_hsa000512.78056232
6* Carbon metabolism_Homo sapiens_hsa012002.76279523
7Vitamin B6 metabolism_Homo sapiens_hsa007502.62127554
8* Pentose phosphate pathway_Homo sapiens_hsa000302.54879065
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.51484397
10DNA replication_Homo sapiens_hsa030302.49204137
11* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.41729717
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.26821860
13Pyruvate metabolism_Homo sapiens_hsa006201.84701801
14Central carbon metabolism in cancer_Homo sapiens_hsa052301.73058207
15One carbon pool by folate_Homo sapiens_hsa006701.71427362
16Mismatch repair_Homo sapiens_hsa034301.64279810
17Galactose metabolism_Homo sapiens_hsa000521.64267584
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.60956237
19Cyanoamino acid metabolism_Homo sapiens_hsa004601.56214928
20Base excision repair_Homo sapiens_hsa034101.51958544
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.50652700
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42048089
23Arginine and proline metabolism_Homo sapiens_hsa003301.37447165
24Synaptic vesicle cycle_Homo sapiens_hsa047211.33668027
25Arginine biosynthesis_Homo sapiens_hsa002201.31072693
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25267810
27RNA transport_Homo sapiens_hsa030131.24128157
28Cell cycle_Homo sapiens_hsa041101.23233824
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.21348943
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.19269533
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18804857
32Proteasome_Homo sapiens_hsa030501.18658420
33Fatty acid elongation_Homo sapiens_hsa000621.17961853
34Non-homologous end-joining_Homo sapiens_hsa034501.13183678
35Lysine degradation_Homo sapiens_hsa003101.10002280
36Vibrio cholerae infection_Homo sapiens_hsa051101.06501895
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05433068
38Sulfur relay system_Homo sapiens_hsa041221.03443026
39Fatty acid metabolism_Homo sapiens_hsa012120.96030816
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95388785
41Oocyte meiosis_Homo sapiens_hsa041140.94699129
42Steroid biosynthesis_Homo sapiens_hsa001000.94486023
43Nucleotide excision repair_Homo sapiens_hsa034200.93453434
44mRNA surveillance pathway_Homo sapiens_hsa030150.90449805
45Propanoate metabolism_Homo sapiens_hsa006400.90295588
46Spliceosome_Homo sapiens_hsa030400.85562344
47HIF-1 signaling pathway_Homo sapiens_hsa040660.85124931
48Glucagon signaling pathway_Homo sapiens_hsa049220.80058314
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79821924
50N-Glycan biosynthesis_Homo sapiens_hsa005100.77460951
51Homologous recombination_Homo sapiens_hsa034400.76737238
52Pyrimidine metabolism_Homo sapiens_hsa002400.76028629
53Phenylalanine metabolism_Homo sapiens_hsa003600.76015143
54AMPK signaling pathway_Homo sapiens_hsa041520.74179251
55Insulin signaling pathway_Homo sapiens_hsa049100.65366328
56* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64043546
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60958418
58Purine metabolism_Homo sapiens_hsa002300.59431834
59Folate biosynthesis_Homo sapiens_hsa007900.58894800
60Fatty acid biosynthesis_Homo sapiens_hsa000610.58751168
61Long-term potentiation_Homo sapiens_hsa047200.57804144
62Thyroid cancer_Homo sapiens_hsa052160.57548702
63Alcoholism_Homo sapiens_hsa050340.55418831
64Glutathione metabolism_Homo sapiens_hsa004800.51658452
65Glioma_Homo sapiens_hsa052140.51281586
66Tyrosine metabolism_Homo sapiens_hsa003500.50459867
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50274539
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49001137
69RNA polymerase_Homo sapiens_hsa030200.48966234
70Thyroid hormone synthesis_Homo sapiens_hsa049180.47145135
71RNA degradation_Homo sapiens_hsa030180.46491473
72Amphetamine addiction_Homo sapiens_hsa050310.44013247
73Fanconi anemia pathway_Homo sapiens_hsa034600.43537027
74mTOR signaling pathway_Homo sapiens_hsa041500.42973411
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39843220
76* Metabolic pathways_Homo sapiens_hsa011000.38183396
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36969376
78Tight junction_Homo sapiens_hsa045300.36624022
79Insulin secretion_Homo sapiens_hsa049110.35830245
80Adherens junction_Homo sapiens_hsa045200.35419723
81Prion diseases_Homo sapiens_hsa050200.34726278
82Bladder cancer_Homo sapiens_hsa052190.34065471
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33882548
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33721121
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32026970
86Nicotine addiction_Homo sapiens_hsa050330.29700112
87Non-small cell lung cancer_Homo sapiens_hsa052230.29541998
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28766193
89Endometrial cancer_Homo sapiens_hsa052130.28601947
90Inositol phosphate metabolism_Homo sapiens_hsa005620.27964300
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.27865266
92Parkinsons disease_Homo sapiens_hsa050120.27420406
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24817093
94Melanogenesis_Homo sapiens_hsa049160.23765029
95Estrogen signaling pathway_Homo sapiens_hsa049150.23021250
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22215851
97Dopaminergic synapse_Homo sapiens_hsa047280.21966221
98Chronic myeloid leukemia_Homo sapiens_hsa052200.21874475
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21708863
100ErbB signaling pathway_Homo sapiens_hsa040120.21537840

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