GPCPD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.11763978
2negative regulation of cell killing (GO:0031342)5.24428026
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.24428026
4regulation of B cell receptor signaling pathway (GO:0050855)5.14907392
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.92478447
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.92478447
7modulation by symbiont of host immune response (GO:0052553)4.92478447
8positive regulation by symbiont of host defense response (GO:0052509)4.92478447
9modulation by symbiont of host defense response (GO:0052031)4.92478447
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.92478447
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.73454817
12cellular extravasation (GO:0045123)4.68955717
13microglial cell activation (GO:0001774)4.59102887
14detection of molecule of bacterial origin (GO:0032490)4.56891289
15regulation of gamma-delta T cell activation (GO:0046643)4.55108216
16response to peptidoglycan (GO:0032494)4.45079750
17detection of other organism (GO:0098543)4.41188800
18positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.40514816
19neutrophil activation involved in immune response (GO:0002283)4.32941854
20macrophage activation involved in immune response (GO:0002281)4.30875533
21fat-soluble vitamin biosynthetic process (GO:0042362)4.30707187
22neutrophil mediated immunity (GO:0002446)4.03559734
23negative regulation of interleukin-12 production (GO:0032695)4.02203941
24regulation of gamma-delta T cell differentiation (GO:0045586)4.01534723
25detection of external biotic stimulus (GO:0098581)3.98614673
26detection of bacterium (GO:0016045)3.94473652
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.86223078
28triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.85964588
29response to muramyl dipeptide (GO:0032495)3.83828239
30macrophage activation (GO:0042116)3.83085335
31L-phenylalanine catabolic process (GO:0006559)3.80877430
32erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.80877430
33urea metabolic process (GO:0019627)3.79597346
34urea cycle (GO:0000050)3.79597346
35kynurenine metabolic process (GO:0070189)3.78342445
36aromatic amino acid family catabolic process (GO:0009074)3.76672279
37negative regulation of lymphocyte mediated immunity (GO:0002707)3.76180069
38negative regulation of T cell mediated immunity (GO:0002710)3.74239489
39tryptophan catabolic process (GO:0006569)3.72401669
40indole-containing compound catabolic process (GO:0042436)3.72401669
41indolalkylamine catabolic process (GO:0046218)3.72401669
42B cell receptor signaling pathway (GO:0050853)3.72131555
43antigen processing and presentation of endogenous antigen (GO:0019883)3.71366170
44detection of biotic stimulus (GO:0009595)3.64996380
45neutrophil activation (GO:0042119)3.62227933
46positive regulation of mast cell activation (GO:0033005)3.60359604
47regulation of protein activation cascade (GO:2000257)3.59658329
48bile acid biosynthetic process (GO:0006699)3.59173021
49fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.57501136
50antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.56773457
51negative thymic T cell selection (GO:0045060)3.54503709
52complement activation, alternative pathway (GO:0006957)3.52439599
53negative T cell selection (GO:0043383)3.51445287
54positive regulation of B cell differentiation (GO:0045579)3.50759448
55regulation of interferon-beta biosynthetic process (GO:0045357)3.50468172
56leukocyte aggregation (GO:0070486)3.49262704
57cysteine metabolic process (GO:0006534)3.47871387
58L-phenylalanine metabolic process (GO:0006558)3.47481079
59erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.47481079
60myeloid leukocyte mediated immunity (GO:0002444)3.46691725
61dicarboxylic acid biosynthetic process (GO:0043650)3.43551467
62nitrogen cycle metabolic process (GO:0071941)3.43488608
63tryptophan metabolic process (GO:0006568)3.42886344
64response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.42440050
65response to host immune response (GO:0052572)3.42440050
66regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.42259862
67regulation of complement activation (GO:0030449)3.40762150
68regulation of triglyceride catabolic process (GO:0010896)3.40210313
69immunoglobulin mediated immune response (GO:0016064)3.40192031
70positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.39403253
71activated T cell proliferation (GO:0050798)3.38838627
72alpha-linolenic acid metabolic process (GO:0036109)3.37581490
73myeloid cell activation involved in immune response (GO:0002275)3.33740697
74regulation of tolerance induction (GO:0002643)3.32050642
75positive thymic T cell selection (GO:0045059)3.30102898
76amino-acid betaine metabolic process (GO:0006577)3.29345328
77granulocyte activation (GO:0036230)3.28126975
78serine family amino acid catabolic process (GO:0009071)3.27926665
79regulation of mast cell activation (GO:0033003)3.27562970
80positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.27291760
81high-density lipoprotein particle remodeling (GO:0034375)3.27287674
82regulation of B cell differentiation (GO:0045577)3.27153438
83tolerance induction (GO:0002507)3.25602222
84positive regulation of granulocyte differentiation (GO:0030854)3.25598130
85peptidyl-glutamic acid carboxylation (GO:0017187)3.25352864
86protein carboxylation (GO:0018214)3.25352864
87cellular ketone body metabolic process (GO:0046950)3.25293336
88positive T cell selection (GO:0043368)3.24925220
89fatty acid transmembrane transport (GO:1902001)3.23342268
90response to host (GO:0075136)3.19716362
91response to host defenses (GO:0052200)3.19716362
92response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.19716362
93respiratory burst (GO:0045730)3.19476351
94antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.16480529
95regulation of mast cell degranulation (GO:0043304)3.15650650
96phospholipid homeostasis (GO:0055091)3.14502251
97germinal center formation (GO:0002467)3.14300693
98T cell migration (GO:0072678)3.12114033
99response to interleukin-15 (GO:0070672)3.12108097
100negative regulation of leukocyte mediated immunity (GO:0002704)3.11826191
101negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.11507854
102glutamate metabolic process (GO:0006536)3.10477498
103carnitine shuttle (GO:0006853)3.10324474
104vitamin transmembrane transport (GO:0035461)3.10000770
105defense response to protozoan (GO:0042832)3.07362870
106regulation of mast cell activation involved in immune response (GO:0033006)3.07360314
107regulation of fibrinolysis (GO:0051917)3.07159033
108positive regulation of fatty acid beta-oxidation (GO:0032000)3.06423551
109regulation of T cell tolerance induction (GO:0002664)3.04887079
110regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.04324060
111reverse cholesterol transport (GO:0043691)3.02868491
112lysine catabolic process (GO:0006554)3.02714253
113lysine metabolic process (GO:0006553)3.02714253
114negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.02710712
115positive regulation of lipid catabolic process (GO:0050996)3.01730750
116positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.00812501
117negative regulation of erythrocyte differentiation (GO:0045647)2.99896832
118negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.99370517
119negative regulation of T-helper cell differentiation (GO:0045623)2.99370517
120regulation of alpha-beta T cell proliferation (GO:0046640)2.99366743
121lymph vessel development (GO:0001945)2.99083632
122positive regulation of mast cell degranulation (GO:0043306)2.98454202
123positive regulation of mast cell activation involved in immune response (GO:0033008)2.98454202
124negative regulation of adaptive immune response (GO:0002820)2.98238656
125phospholipid efflux (GO:0033700)2.97565358
126glyoxylate metabolic process (GO:0046487)2.95315025
127negative regulation of fibrinolysis (GO:0051918)2.94878798
128regulation of sequestering of triglyceride (GO:0010889)2.94313605
1292-oxoglutarate metabolic process (GO:0006103)2.93030936
130S-adenosylmethionine metabolic process (GO:0046500)2.92531605
131regulation of skeletal muscle contraction (GO:0014819)2.91224336
132T cell selection (GO:0045058)2.90993000
133bile acid metabolic process (GO:0008206)2.90330244
134homocysteine metabolic process (GO:0050667)2.90269808
135plasma lipoprotein particle remodeling (GO:0034369)2.89556313
136protein-lipid complex remodeling (GO:0034368)2.89556313
137macromolecular complex remodeling (GO:0034367)2.89556313
138positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.89540211
139interferon-gamma production (GO:0032609)2.89493554
140alpha-amino acid catabolic process (GO:1901606)2.86831038
141interferon-gamma-mediated signaling pathway (GO:0060333)2.86329755
142regulation of interleukin-8 biosynthetic process (GO:0045414)2.85535323
143leukocyte migration involved in inflammatory response (GO:0002523)2.83426925
144vascular endothelial growth factor signaling pathway (GO:0038084)2.81884515
145sulfur amino acid catabolic process (GO:0000098)2.79103084
146positive regulation of dendritic spine morphogenesis (GO:0061003)2.77620021
147NAD biosynthetic process (GO:0009435)2.77097923
148regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.77060137
149regulation of dendritic cell antigen processing and presentation (GO:0002604)2.76464641
150positive regulation of fatty acid oxidation (GO:0046321)2.76346710
151carnitine metabolic process (GO:0009437)2.75374636
152cellular response to interleukin-15 (GO:0071350)2.75316085
153myeloid leukocyte activation (GO:0002274)2.75246488
154triglyceride homeostasis (GO:0070328)2.74532454
155acylglycerol homeostasis (GO:0055090)2.74532454
156response to protozoan (GO:0001562)2.73196404
157regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.72923064
158T-helper 1 type immune response (GO:0042088)2.70861284
159ketone body metabolic process (GO:1902224)2.70615426
160cholesterol efflux (GO:0033344)2.70039420
161arginine metabolic process (GO:0006525)2.68662888
162regulation of cholesterol esterification (GO:0010872)2.68508297
163cellular glucuronidation (GO:0052695)2.68231656
164short-chain fatty acid metabolic process (GO:0046459)2.68188824
165regulation of myeloid leukocyte mediated immunity (GO:0002886)2.67955322
166phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.66571414
167cellular biogenic amine catabolic process (GO:0042402)2.66170112
168amine catabolic process (GO:0009310)2.66170112
169negative regulation of immunoglobulin mediated immune response (GO:0002890)2.65780650
170negative regulation of B cell mediated immunity (GO:0002713)2.65780650
171negative regulation of B cell proliferation (GO:0030889)2.65041501
172quaternary ammonium group transport (GO:0015697)2.61895938
173iron ion import (GO:0097286)2.61372980
174positive regulation of cellular amide metabolic process (GO:0034250)2.60391938
175complement activation, classical pathway (GO:0006958)2.58291266
176regulation of bile acid biosynthetic process (GO:0070857)2.57850382
177aromatic amino acid family metabolic process (GO:0009072)2.57648064
178plasma lipoprotein particle assembly (GO:0034377)2.57330242
179skeletal muscle adaptation (GO:0043501)2.57224091
180cellular amino acid catabolic process (GO:0009063)2.56917598
181complement activation (GO:0006956)2.56314269
182bile acid and bile salt transport (GO:0015721)2.55000703
183fatty acid beta-oxidation (GO:0006635)2.53010751
184nicotinamide nucleotide biosynthetic process (GO:0019359)2.52869390
185pyridine nucleotide biosynthetic process (GO:0019363)2.52869390
186protein targeting to Golgi (GO:0000042)2.52761289
187protein activation cascade (GO:0072376)2.52228117
188glycogen catabolic process (GO:0005980)2.51766456
189alkaloid metabolic process (GO:0009820)2.49188099
190carnitine transmembrane transport (GO:1902603)2.48428574
191fatty acid catabolic process (GO:0009062)2.47274147
192regulation of fatty acid beta-oxidation (GO:0031998)2.47098239
193negative regulation of protein activation cascade (GO:2000258)2.46090812
194tyrosine metabolic process (GO:0006570)2.45557636
195urate metabolic process (GO:0046415)2.44894753
196muscle hypertrophy in response to stress (GO:0003299)2.44546572
197cardiac muscle adaptation (GO:0014887)2.44546572
198cardiac muscle hypertrophy in response to stress (GO:0014898)2.44546572
199fatty acid oxidation (GO:0019395)2.44014126

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.69209017
2* RXR_22158963_ChIP-Seq_LIVER_Mouse3.74416856
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.52222115
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.37002137
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.27189178
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.26840735
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.22756118
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.12585329
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.99323446
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.98684681
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.83916001
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.61753467
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.55338036
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.52588033
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.47898908
16MYB_26560356_Chip-Seq_TH2_Human2.43275481
17GATA1_22025678_ChIP-Seq_K562_Human2.22068262
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.10429655
19SPI1_23547873_ChIP-Seq_NB4_Human2.05480255
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.03926067
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.03876254
22SPI1_23127762_ChIP-Seq_K562_Human1.94134717
23MYB_26560356_Chip-Seq_TH1_Human1.93179401
24VDR_24763502_ChIP-Seq_THP-1_Human1.91526737
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.87448414
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82458920
27GATA3_27048872_Chip-Seq_THYMUS_Human1.78097847
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.71374421
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.64643001
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.64004543
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63188461
32MAF_26560356_Chip-Seq_TH1_Human1.61191181
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.59014777
34* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.55633545
35TAF15_26573619_Chip-Seq_HEK293_Human1.54752496
36FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.52694208
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.52286395
38GATA3_26560356_Chip-Seq_TH2_Human1.50704830
39ZNF263_19887448_ChIP-Seq_K562_Human1.50196278
40CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.49246784
41PU_27001747_Chip-Seq_BMDM_Mouse1.45681409
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45599918
43CLOCK_20551151_ChIP-Seq_293T_Human1.44846553
44GATA1_19941826_ChIP-Seq_K562_Human1.43620747
45RUNX_20019798_ChIP-Seq_JUKART_Human1.40970470
46GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39916597
47TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.39009835
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.38669371
49FOXA2_19822575_ChIP-Seq_HepG2_Human1.35461414
50GBX2_23144817_ChIP-Seq_PC3_Human1.34783831
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.33551244
52UTX_26944678_Chip-Seq_JUKART_Human1.33049947
53TCF7_22412390_ChIP-Seq_EML_Mouse1.31300335
54RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.31080349
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30777533
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29890100
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28370822
58NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.28008769
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26327106
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25097420
61BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22305148
62SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.22165305
63SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21764100
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19002878
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18977456
66VDR_21846776_ChIP-Seq_THP-1_Human1.18451915
67IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18084769
68SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.15784498
69PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15519678
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.14686870
71* SMRT_27268052_Chip-Seq_Bcells_Human1.13941270
72NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13460409
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13460409
74* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12335266
75AR_21572438_ChIP-Seq_LNCaP_Human1.11871236
76RNF2_18974828_ChIP-Seq_MESCs_Mouse1.11827148
77EZH2_18974828_ChIP-Seq_MESCs_Mouse1.11827148
78JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11654450
79SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10978911
80* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10859375
81GATA2_21666600_ChIP-Seq_HMVEC_Human1.09659055
82MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09044293
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08828662
84GATA2_19941826_ChIP-Seq_K562_Human1.08578768
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08247499
86* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07765494
87EZH2_22144423_ChIP-Seq_EOC_Human1.07259038
88TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.06543051
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06020289
90NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05785406
91AR_25329375_ChIP-Seq_VCAP_Human1.05168841
92SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04613690
93EP300_21415370_ChIP-Seq_HL-1_Mouse1.04501882
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04121406
95EED_16625203_ChIP-ChIP_MESCs_Mouse1.03925742
96ESR2_21235772_ChIP-Seq_MCF-7_Human1.02449757
97GATA1_19941827_ChIP-Seq_MEL_Mouse1.02404669
98RXR_22108803_ChIP-Seq_LS180_Human1.01392544
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01045786
100SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00634965
101SMAD4_21799915_ChIP-Seq_A2780_Human1.00412283
102BCAT_22108803_ChIP-Seq_LS180_Human0.99047792
103TCF4_18268006_ChIP-ChIP_LS174T_Human0.97884063
104GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97462449
105LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97415470
106GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96474838
107DROSHA_22980978_ChIP-Seq_HELA_Human0.96305170
108AHR_22903824_ChIP-Seq_MCF-7_Human0.96209145
109IRF8_27001747_Chip-Seq_BMDM_Mouse0.95707836
110NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95474326
111* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95467464
112* MYC_22102868_ChIP-Seq_BL_Human0.95019579
113TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94612772
114KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94400760
115SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93051369
116CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92209302
117VDR_24787735_ChIP-Seq_THP-1_Human0.91452785
118ARNT_22903824_ChIP-Seq_MCF-7_Human0.91123797
119POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90854805
120SOX2_21211035_ChIP-Seq_LN229_Gbm0.90473888
121AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88312091
122SMAD3_21741376_ChIP-Seq_EPCs_Human0.87703113
123CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87579429
124P300_19829295_ChIP-Seq_ESCs_Human0.87077686
125* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.86823371
126NR3C1_23031785_ChIP-Seq_PC12_Mouse0.86681149
127KDM2B_26808549_Chip-Seq_DND41_Human0.86229481
128NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86223473
129FOXO3_23340844_ChIP-Seq_DLD1_Human0.86161265
130* SMAD4_21741376_ChIP-Seq_EPCs_Human0.86151904
131* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85437220
132* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84789163
133* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84733077
134MAF_26560356_Chip-Seq_TH2_Human0.83960473
135FOXM1_26456572_ChIP-Seq_MCF-7_Human0.83933733
136KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.83519033
137GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83373977
138* TBX20_22328084_ChIP-Seq_HEART_Mouse0.82895311
139* TBX20_22080862_ChIP-Seq_HEART_Mouse0.82895311
140SCL_19346495_ChIP-Seq_HPC-7_Human0.82878005
141RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.82814458
142PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82723904
143PRDM14_20953172_ChIP-Seq_ESCs_Human0.81673378
144RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.79589330
145JARID2_20075857_ChIP-Seq_MESCs_Mouse0.78610196
146CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78491408
147KDM2B_26808549_Chip-Seq_K562_Human0.77632437
148UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.77467863
149NOTCH1_21737748_ChIP-Seq_TLL_Human0.77371555
150FLI1_21867929_ChIP-Seq_TH2_Mouse0.76947721
151EZH2_27294783_Chip-Seq_NPCs_Mouse0.76059497
152* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75631227
153STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.75539877
154TP53_16413492_ChIP-PET_HCT116_Human0.75343123
155STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.75258891
156SMAD4_21741376_ChIP-Seq_HESCs_Human0.75226784
157SALL4_22934838_ChIP-ChIP_CD34+_Human0.75206017
158KDM2B_26808549_Chip-Seq_JURKAT_Human0.74778759
159ER_23166858_ChIP-Seq_MCF-7_Human0.72321394
160CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.71704410
161OCT4_21477851_ChIP-Seq_ESCs_Mouse0.70223842
162TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.69122355
163POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.69122355
164CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.68427771
165FLI1_27457419_Chip-Seq_LIVER_Mouse0.68343317
166KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.68277423
167GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.67523107

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.14939763
2MP0005085_abnormal_gallbladder_physiolo4.48746463
3MP0005360_urolithiasis4.25866645
4MP0005365_abnormal_bile_salt3.89995193
5MP0008875_abnormal_xenobiotic_pharmacok3.41761265
6MP0003436_decreased_susceptibility_to3.33928109
7MP0002254_reproductive_system_inflammat2.92354631
8MP0005167_abnormal_blood-brain_barrier2.84381408
9MP0002419_abnormal_innate_immunity2.83463737
10MP0003646_muscle_fatigue2.75956174
11MP0002138_abnormal_hepatobiliary_system2.75844689
12MP0010329_abnormal_lipoprotein_level2.75201308
13MP0005671_abnormal_response_to2.73718462
14MP0005000_abnormal_immune_tolerance2.70947171
15MP0000685_abnormal_immune_system2.70122060
16MP0000569_abnormal_digit_pigmentation2.68207613
17MP0005387_immune_system_phenotype2.56823797
18MP0001790_abnormal_immune_system2.56823797
19MP0002723_abnormal_immune_serum2.53429317
20MP0004130_abnormal_muscle_cell2.53328271
21MP0002452_abnormal_antigen_presenting2.51734667
22MP0005025_abnormal_response_to2.51289963
23MP0008260_abnormal_autophagy2.44979951
24MP0002420_abnormal_adaptive_immunity2.44110916
25MP0009785_altered_susceptibility_to2.41671153
26MP0003252_abnormal_bile_duct2.41215394
27MP0001819_abnormal_immune_cell2.40556726
28MP0003763_abnormal_thymus_physiology2.38540067
29MP0010368_abnormal_lymphatic_system2.35321476
30MP0004147_increased_porphyrin_level2.35128281
31MP0003656_abnormal_erythrocyte_physiolo2.30613848
32MP0002837_dystrophic_cardiac_calcinosis2.19158397
33MP0002148_abnormal_hypersensitivity_rea2.17686381
34MP0001879_abnormal_lymphatic_vessel2.10300168
35MP0002405_respiratory_system_inflammati2.07620963
36MP0004510_myositis2.06405781
37MP0005464_abnormal_platelet_physiology2.02616460
38MP0003300_gastrointestinal_ulcer2.00646268
39MP0003172_abnormal_lysosome_physiology1.97942691
40MP0009840_abnormal_foam_cell1.97763612
41MP0002398_abnormal_bone_marrow1.95631389
42MP0003806_abnormal_nucleotide_metabolis1.95096688
43MP0000716_abnormal_immune_system1.88327309
44MP0004484_altered_response_of1.83361104
45MP0006082_CNS_inflammation1.80577847
46MP0000465_gastrointestinal_hemorrhage1.75340333
47MP0005332_abnormal_amino_acid1.75237345
48MP0003183_abnormal_peptide_metabolism1.74248398
49MP0004883_abnormal_blood_vessel1.71865600
50MP0005670_abnormal_white_adipose1.71252194
51MP0002009_preneoplasia1.67883469
52MP0005083_abnormal_biliary_tract1.67139043
53MP0004947_skin_inflammation1.66105809
54MP0004381_abnormal_hair_follicle1.64689165
55MP0004215_abnormal_myocardial_fiber1.64327704
56MP0000689_abnormal_spleen_morphology1.63076741
57MP0001851_eye_inflammation1.60191526
58MP0001845_abnormal_inflammatory_respons1.59670136
59MP0002722_abnormal_immune_system1.59461987
60MP0002118_abnormal_lipid_homeostasis1.58223764
61MP0010155_abnormal_intestine_physiology1.57376208
62MP0001533_abnormal_skeleton_physiology1.53622593
63MP0000609_abnormal_liver_physiology1.52732695
64MP0005310_abnormal_salivary_gland1.52388820
65MP0006138_congestive_heart_failure1.51834426
66MP0005075_abnormal_melanosome_morpholog1.48693281
67MP0002429_abnormal_blood_cell1.45364813
68MP0001545_abnormal_hematopoietic_system1.45206048
69MP0005397_hematopoietic_system_phenotyp1.45206048
70MP0005084_abnormal_gallbladder_morpholo1.44065321
71MP0009278_abnormal_bone_marrow1.43705932
72MP0001666_abnormal_nutrient_absorption1.43599305
73MP0000703_abnormal_thymus_morphology1.42254309
74MP0004019_abnormal_vitamin_homeostasis1.39973367
75MP0002971_abnormal_brown_adipose1.38836482
76MP0002396_abnormal_hematopoietic_system1.35877216
77MP0004036_abnormal_muscle_relaxation1.34358091
78MP0004859_abnormal_synaptic_plasticity1.34346814
79MP0002822_catalepsy1.31429173
80MP0001873_stomach_inflammation1.31311808
81MP0003866_abnormal_defecation1.31074617
82MP0000751_myopathy1.30920497
83MP0005174_abnormal_tail_pigmentation1.29403086
84MP0005164_abnormal_response_to1.28686946
85MP0000015_abnormal_ear_pigmentation1.26641495
86MP0005319_abnormal_enzyme/_coenzyme1.26594211
87MP0003191_abnormal_cellular_cholesterol1.26237327
88MP0004145_abnormal_muscle_electrophysio1.24104154
89MP0009764_decreased_sensitivity_to1.20890406
90MP0005620_abnormal_muscle_contractility1.20524870
91MP0003195_calcinosis1.18624894
92MP0005584_abnormal_enzyme/coenzyme_acti1.17943563
93MP0002166_altered_tumor_susceptibility1.16898144
94MP0005385_cardiovascular_system_phenoty1.13987016
95MP0001544_abnormal_cardiovascular_syste1.13987016
96MP0003868_abnormal_feces_composition1.13404990
97MP0002998_abnormal_bone_remodeling1.13227982
98MP0005535_abnormal_body_temperature1.10841555
99MP0002132_abnormal_respiratory_system1.08000694
100MP0005330_cardiomyopathy1.07770353
101MP0008057_abnormal_DNA_replication1.07342779
102MP0003724_increased_susceptibility_to1.07020307
103MP0004087_abnormal_muscle_fiber1.05688010
104MP0005451_abnormal_body_composition1.05160399
105MP0010630_abnormal_cardiac_muscle1.04676008
106MP0009333_abnormal_splenocyte_physiolog1.04222685
107MP0000858_altered_metastatic_potential1.01298588
108MP0000749_muscle_degeneration1.00370258
109MP0004808_abnormal_hematopoietic_stem1.00362291
110MP0008004_abnormal_stomach_pH0.97962322
111MP0002106_abnormal_muscle_physiology0.97823866
112MP0002277_abnormal_respiratory_mucosa0.96689700
113MP0003091_abnormal_cell_migration0.95431405
114MP0003690_abnormal_glial_cell0.94845092
115MP0002972_abnormal_cardiac_muscle0.91910446
116MP0003221_abnormal_cardiomyocyte_apopto0.90323290
117MP0002928_abnormal_bile_duct0.89781537
118MP0000604_amyloidosis0.88475378
119MP0003633_abnormal_nervous_system0.84135494
120MP0003879_abnormal_hair_cell0.84054704
121MP0005369_muscle_phenotype0.83896302
122MP0006035_abnormal_mitochondrial_morpho0.83869613
123MP0001764_abnormal_homeostasis0.83853283
124MP0005334_abnormal_fat_pad0.83729737
125MP0009765_abnormal_xenobiotic_induced0.83474382
126MP0001501_abnormal_sleep_pattern0.82979897
127MP0000371_diluted_coat_color0.82282602
128MP0002332_abnormal_exercise_endurance0.81294655
129MP0009697_abnormal_copulation0.80817898
130MP0008995_early_reproductive_senescence0.80654597
131MP0006036_abnormal_mitochondrial_physio0.80643784
132MP0002269_muscular_atrophy0.78262315
133MP0001835_abnormal_antigen_presentation0.78146334
134MP0002876_abnormal_thyroid_physiology0.78032562
135MP0002006_tumorigenesis0.77935327
136MP0000343_altered_response_to0.77521611
137MP0005388_respiratory_system_phenotype0.76546451
138MP0002133_abnormal_respiratory_system0.76546451
139MP0005666_abnormal_adipose_tissue0.76142486
140MP0004084_abnormal_cardiac_muscle0.75949788
141MP0003635_abnormal_synaptic_transmissio0.75301034
142MP0003045_fibrosis0.75078575
143MP0003787_abnormal_imprinting0.74768035
144MP0003828_pulmonary_edema0.74160223
145MP0000598_abnormal_liver_morphology0.73927166
146MP0002078_abnormal_glucose_homeostasis0.73777642
147MP0000747_muscle_weakness0.72998147
148MP0002127_abnormal_cardiovascular_syste0.71928662
149MP0001663_abnormal_digestive_system0.71267070
150MP0009763_increased_sensitivity_to0.70870282
151MP0003631_nervous_system_phenotype0.70800166
152MP0000230_abnormal_systemic_arterial0.70238771
153MP0003448_altered_tumor_morphology0.69375110
154MP0005647_abnormal_sex_gland0.68702316
155MP0005058_abnormal_lysosome_morphology0.68698978
156MP0004085_abnormal_heartbeat0.68219385
157MP0003303_peritoneal_inflammation0.67348746
158MP0008961_abnormal_basal_metabolism0.66736530
159MP0000249_abnormal_blood_vessel0.66671955
160MP0009115_abnormal_fat_cell0.65354467
161MP0003075_altered_response_to0.65347138
162MP0005165_increased_susceptibility_to0.64889161
163MP0001853_heart_inflammation0.64108231
164MP0000759_abnormal_skeletal_muscle0.63391992
165MP0008874_decreased_physiological_sensi0.62784374
166MP0009046_muscle_twitch0.62139389
167MP0008469_abnormal_protein_level0.61519251
168MP0001800_abnormal_humoral_immune0.61385001
169MP0005166_decreased_susceptibility_to0.60758861
170MP0004270_analgesia0.60275495
171MP0001986_abnormal_taste_sensitivity0.58621596

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.62587670
2Recurrent bacterial skin infections (HP:0005406)5.49215853
3Recurrent abscess formation (HP:0002722)4.98653944
4Retrobulbar optic neuritis (HP:0100654)4.74853187
5Optic neuritis (HP:0100653)4.74853187
6Myositis (HP:0100614)4.65206134
7Deep venous thrombosis (HP:0002625)4.57482366
8Stomatitis (HP:0010280)4.50634599
9Prolonged partial thromboplastin time (HP:0003645)4.46239587
10Orchitis (HP:0100796)4.45055408
11Abnormality of macrophages (HP:0004311)4.35754897
12Elevated erythrocyte sedimentation rate (HP:0003565)4.32133426
13Hypochromic microcytic anemia (HP:0004840)4.31890612
14Intrahepatic cholestasis (HP:0001406)4.21987104
15Recurrent fungal infections (HP:0002841)4.12128181
16Exercise-induced muscle cramps (HP:0003710)4.05392714
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.95942564
18Chronic mucocutaneous candidiasis (HP:0002728)3.92677279
19Recurrent cutaneous fungal infections (HP:0011370)3.92677279
20Recurrent skin infections (HP:0001581)3.84954618
21Xanthomatosis (HP:0000991)3.80775128
22Hyperlipoproteinemia (HP:0010980)3.80335535
23Mediastinal lymphadenopathy (HP:0100721)3.79846100
24Hypoalphalipoproteinemia (HP:0003233)3.79689977
25Gastrointestinal infarctions (HP:0005244)3.77376862
26T lymphocytopenia (HP:0005403)3.76917988
27Facial diplegia (HP:0001349)3.72215916
28Keratoconjunctivitis sicca (HP:0001097)3.65458933
29Abnormality of T cell number (HP:0011839)3.61652728
30Meningitis (HP:0001287)3.56915179
31Exercise-induced myalgia (HP:0003738)3.54628295
32Vasculitis (HP:0002633)3.53026708
33Hypoglycemic coma (HP:0001325)3.52950689
34Complement deficiency (HP:0004431)3.52898278
35Abnormality of aromatic amino acid family metabolism (HP:0004338)3.41816088
36Keratoconjunctivitis (HP:0001096)3.39452582
37Hypolipoproteinemia (HP:0010981)3.38759430
38Hypobetalipoproteinemia (HP:0003563)3.36921740
39Epidermoid cyst (HP:0200040)3.35866774
40Encephalitis (HP:0002383)3.34651707
41Joint hemorrhage (HP:0005261)3.33142375
42Spontaneous hematomas (HP:0007420)3.31440834
43Abnormality of monocarboxylic acid metabolism (HP:0010996)3.25237166
44Recurrent viral infections (HP:0004429)3.21885970
45Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.11809117
46Hemoptysis (HP:0002105)3.10842843
47Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.09184293
48Pulmonary infiltrates (HP:0002113)3.06406455
49Obstructive lung disease (HP:0006536)3.03195889
50Chronic obstructive pulmonary disease (HP:0006510)3.03195889
51Prolonged bleeding time (HP:0003010)3.01653220
52Leukocytosis (HP:0001974)2.99473600
53Hyperammonemia (HP:0001987)2.99288960
54Gingivitis (HP:0000230)2.98601489
55Progressive inability to walk (HP:0002505)2.96338194
56Chest pain (HP:0100749)2.95667914
57Poikilocytosis (HP:0004447)2.93889645
58Polycythemia (HP:0001901)2.91830901
59Ketosis (HP:0001946)2.90126049
60Gingival bleeding (HP:0000225)2.88234501
61Abnormality of T cells (HP:0002843)2.88023647
62Cholelithiasis (HP:0001081)2.86723280
63Panhypogammaglobulinemia (HP:0003139)2.85219880
64Urticaria (HP:0001025)2.85202523
65Arterial thrombosis (HP:0004420)2.81793247
66Myoglobinuria (HP:0002913)2.80046383
67Abnormality of fatty-acid metabolism (HP:0004359)2.77873390
68Hyperglycinuria (HP:0003108)2.76687231
69Abnormality of the common coagulation pathway (HP:0010990)2.75848319
70Myocardial infarction (HP:0001658)2.73465757
71Inflammation of the large intestine (HP:0002037)2.70241040
72Muscle hypertrophy of the lower extremities (HP:0008968)2.68738268
73Hyperinsulinemic hypoglycemia (HP:0000825)2.67538641
74Abnormal gallbladder morphology (HP:0012437)2.63730033
75Viral hepatitis (HP:0006562)2.62496026
76Esophageal varix (HP:0002040)2.62127271
77Calf muscle hypertrophy (HP:0008981)2.61657592
78Hyperglycinemia (HP:0002154)2.61051299
79Hyperbilirubinemia (HP:0002904)2.59448007
80Epistaxis (HP:0000421)2.58930854
81Cellulitis (HP:0100658)2.57318083
82Autoimmune hemolytic anemia (HP:0001890)2.55970898
83Hypoglycemic seizures (HP:0002173)2.51964684
84Recurrent bronchitis (HP:0002837)2.49323573
85Pustule (HP:0200039)2.48695948
86Neoplasm of the tracheobronchial system (HP:0100552)2.48468215
87Hypercholesterolemia (HP:0003124)2.46965310
88Gangrene (HP:0100758)2.45512189
89Abnormality of glycine metabolism (HP:0010895)2.44516769
90Abnormality of serine family amino acid metabolism (HP:0010894)2.44516769
91Abnormality of the heme biosynthetic pathway (HP:0010472)2.44379432
92Gastrointestinal inflammation (HP:0004386)2.44094386
93Pulmonary embolism (HP:0002204)2.43881527
94Acanthocytosis (HP:0001927)2.43196529
95Agammaglobulinemia (HP:0004432)2.39168869
96Osteomyelitis (HP:0002754)2.38252140
97Atrioventricular block (HP:0001678)2.37339986
98Stomach cancer (HP:0012126)2.36947889
99Papilledema (HP:0001085)2.36908663
100Eosinophilia (HP:0001880)2.36491590
101Spontaneous abortion (HP:0005268)2.35574997
102Abnormality of T cell physiology (HP:0011840)2.35259536
103Slow saccadic eye movements (HP:0000514)2.34761514
104Granulocytopenia (HP:0001913)2.33463219
105Subacute progressive viral hepatitis (HP:0006572)2.32160207
106Alveolar cell carcinoma (HP:0006519)2.31567742
107Amyloidosis (HP:0011034)2.31263071
108Recurrent gram-negative bacterial infections (HP:0005420)2.31050977
109Abnormality of glutamine family amino acid metabolism (HP:0010902)2.29345304
110Increased IgE level (HP:0003212)2.28696228
111Skin nodule (HP:0200036)2.28093993
112Abnormality of the pleura (HP:0002103)2.26720242
113Muscle fiber inclusion bodies (HP:0100299)2.23465139
114Lymphopenia (HP:0001888)2.22959055
115Recurrent sinusitis (HP:0011108)2.22393282
116Ketoacidosis (HP:0001993)2.21942854
117Fat malabsorption (HP:0002630)2.20313061
118Abnormality of methionine metabolism (HP:0010901)2.20028302
119Abnormality of the fingertips (HP:0001211)2.19706246
120Inability to walk (HP:0002540)2.19569162
121Abnormality of complement system (HP:0005339)2.19499933
122Sudden death (HP:0001699)2.18843242
123Rhabdomyolysis (HP:0003201)2.18011663
124Paralysis (HP:0003470)2.17362835
125Abnormality of sulfur amino acid metabolism (HP:0004339)2.17347322
126Reticulocytosis (HP:0001923)2.16862140
127Hematochezia (HP:0002573)2.16834574
128Abnormality of purine metabolism (HP:0004352)2.16208515
129IgM deficiency (HP:0002850)2.15941155
130Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.15302676
131Anorexia (HP:0002039)2.14474468
132Abnormality of the intrinsic pathway (HP:0010989)2.13661158
133Abnormality of eosinophils (HP:0001879)2.12723525
134Hyperventilation (HP:0002883)2.12549187
135Muscle stiffness (HP:0003552)2.12146370
136EMG: myopathic abnormalities (HP:0003458)2.11828019
137Abnormality of aspartate family amino acid metabolism (HP:0010899)2.11511429
138Abnormality of the left ventricular outflow tract (HP:0011103)2.10492285
139Subaortic stenosis (HP:0001682)2.10492285
140Hyperglycemia (HP:0003074)2.10268929
141Confusion (HP:0001289)2.09541744
142Gout (HP:0001997)2.09227450
143Keratitis (HP:0000491)2.08369216
144Episodic fever (HP:0001954)2.07135901
145Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.05372855
146Systemic lupus erythematosus (HP:0002725)2.04565104
147Autoimmune thrombocytopenia (HP:0001973)2.04257694
148Abnormality of cells of the lymphoid lineage (HP:0012140)2.04000985
149Colitis (HP:0002583)2.02872497
150Heart block (HP:0012722)2.00649919
151Vertigo (HP:0002321)1.98837339
152Tetraparesis (HP:0002273)1.98565570
153Hemiplegia (HP:0002301)1.98183066
154Sepsis (HP:0100806)1.97932402
155Hepatocellular carcinoma (HP:0001402)1.97504483
156Interstitial pulmonary disease (HP:0006530)1.95829229
157Focal motor seizures (HP:0011153)1.95362091
158Vascular calcification (HP:0004934)1.95218563
159Status epilepticus (HP:0002133)1.94826359
160Abnormality of the vasculature of the conjunctiva (HP:0008054)1.93950763
161Metabolic acidosis (HP:0001942)1.93567303
162Fatigue (HP:0012378)1.93476724
163Abnormality of the prostate (HP:0008775)1.92822916
164Increased IgM level (HP:0003496)1.92364197
165Restrictive lung disease (HP:0002091)1.91730699
166Chronic diarrhea (HP:0002028)1.91629220
167Mitral stenosis (HP:0001718)1.90084738
168Sensorimotor neuropathy (HP:0007141)1.89824047
169Polyneuropathy (HP:0001271)1.89727786
170Muscle fiber splitting (HP:0003555)1.89237134
171Difficulty running (HP:0009046)1.89058304
172Bundle branch block (HP:0011710)1.87666671
173Abnormality of nucleobase metabolism (HP:0010932)1.87627679
174Amaurosis fugax (HP:0100576)1.86436713
175Microcytic anemia (HP:0001935)1.86308752
176Syncope (HP:0001279)1.86200111
177Hypochromic anemia (HP:0001931)1.86074237
178Glomerulopathy (HP:0100820)1.85401887
179Dysmetric saccades (HP:0000641)1.84624045
180Annular pancreas (HP:0001734)1.84493591
181Abnormality of serum amino acid levels (HP:0003112)1.84392203
182Abnormality of the peritoneum (HP:0002585)1.83816544
183Increased CSF protein (HP:0002922)1.83631296
184Delayed CNS myelination (HP:0002188)1.82529611
185Peritonitis (HP:0002586)1.82510194
186Excessive salivation (HP:0003781)1.82153668
187Drooling (HP:0002307)1.82153668
188Hyperkalemia (HP:0002153)1.81899131
189Gastrointestinal stroma tumor (HP:0100723)1.81609127
190Fair hair (HP:0002286)1.81583317
191Pancreatic islet-cell hyperplasia (HP:0004510)1.81572622
192Abnormality of the endocardium (HP:0004306)1.81554157
193IgG deficiency (HP:0004315)1.81053894
194Verrucae (HP:0200043)1.80332022
195Papilloma (HP:0012740)1.80332022

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE19.01066893
2BLK3.29248436
3GRK12.54184735
4IRAK42.54012119
5TXK2.07681286
6PRPF4B2.05163990
7OBSCN1.98137634
8PHKG21.97960687
9PHKG11.97960687
10CAMK1D1.89377873
11FGR1.86066412
12PRKAA21.81834197
13ZAP701.81557315
14MAP3K141.80251508
15BTK1.79643523
16CAMK1G1.76764632
17INSRR1.71388468
18MAP2K41.70647644
19MAP3K71.70130604
20IRAK11.68337585
21EPHA41.64090470
22TEC1.62888548
23JAK31.60781586
24TTN1.58205614
25RIPK41.54060709
26MAPK121.53583968
27MAP3K131.52656649
28HCK1.49509182
29SGK21.46709367
30PINK11.43898921
31AKT31.43379123
32SGK31.40122716
33LYN1.35305397
34ITK1.35096709
35MARK31.34635029
36PIK3CA1.33255612
37FGFR31.29766658
38BMX1.29179252
39MAPK71.27466483
40MAP3K121.26126089
41MAPK151.23309137
42KDR1.23253784
43JAK11.23227481
44CSF1R1.23174170
45PIK3CG1.21850505
46EPHB11.21674193
47KIT1.20618136
48BCKDK1.19582400
49YES11.15249059
50TGFBR21.15033613
51MAP3K61.14613617
52PRKAA11.14100107
53IRAK21.13007086
54MATK1.12188746
55TYK21.09634078
56LCK1.09357894
57FGFR41.07633219
58SIK31.03954822
59PAK31.03769112
60TNIK1.00035980
61MAP3K10.96579143
62PIM10.92630746
63MAP2K30.92156718
64TNK20.89505148
65NTRK30.87489681
66PDPK10.86914553
67PTK2B0.86063395
68MARK20.85898923
69SIK10.83864988
70KSR10.83187128
71JAK20.79773147
72BRD40.79283822
73WNK10.78665457
74SGK10.78258502
75CAMK40.74568671
76IKBKE0.73101417
77SGK4940.72806760
78SGK2230.72806760
79ACVR1B0.72182982
80TBK10.71055857
81MAPK110.70197678
82KSR20.69488686
83MAP3K50.69452065
84MARK10.69203813
85PDK10.68861140
86PRKCE0.68016377
87STK100.67104458
88PRKCG0.66935476
89MAP3K20.66762482
90IKBKB0.65948540
91NLK0.65627669
92MAPK40.64033762
93MAP3K40.62703188
94MAP2K10.61713142
95DAPK20.61612263
96RET0.61581651
97CAMKK20.60295920
98GRK60.59763463
99STK240.59522187
100NEK90.58038536
101GRK70.57710823
102BMPR20.56965290
103PTK60.56675023
104CHUK0.55612690
105PKN10.54908714
106CAMK10.54865049
107TAOK10.54445929
108MAP3K90.53765436
109PRKCQ0.53500855
110DYRK30.53342154
111CAMKK10.52860336
112ZAK0.52541797
113PRKCH0.52428353
114IRAK30.52216026
115MAP4K10.50629473
116FYN0.50167164
117DYRK1A0.50028151
118SIK20.49372810
119TAOK30.49081986
120MAP2K20.49075021
121ERBB20.48412008
122PRKCZ0.47813156
123HIPK20.47272405
124EPHA30.47175640
125MYLK0.47019051
126LMTK20.45266840
127PRKD10.45215025
128PDK20.45056826
129PDK40.43858696
130PDK30.43858696
131FES0.43742314
132PRKACG0.43649718
133EGFR0.42733182
134SYK0.41871201
135LRRK20.41807769
136CDK60.41676983
137TRPM70.41353915
138CDC42BPA0.41014972
139MAP3K110.40337764
140CSK0.40182563
141DYRK1B0.40051871
142MAP3K30.38990757
143MELK0.38152412
144RPS6KA30.37334388
145NEK60.36620177
146STK110.36490415
147CDK190.35605486
148FRK0.34088990

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.95846242
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.60008003
3Nitrogen metabolism_Homo sapiens_hsa009103.32493182
4Leishmaniasis_Homo sapiens_hsa051402.88175410
5Arginine biosynthesis_Homo sapiens_hsa002202.83352016
6Graft-versus-host disease_Homo sapiens_hsa053322.27828777
7Allograft rejection_Homo sapiens_hsa053302.24047924
8Fatty acid degradation_Homo sapiens_hsa000712.16154410
9Complement and coagulation cascades_Homo sapiens_hsa046102.14406754
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.13461921
11Autoimmune thyroid disease_Homo sapiens_hsa053202.08789622
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.03472703
13Bile secretion_Homo sapiens_hsa049762.03000426
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.00344356
15PPAR signaling pathway_Homo sapiens_hsa033201.97722998
16Tuberculosis_Homo sapiens_hsa051521.94896687
17Tryptophan metabolism_Homo sapiens_hsa003801.91091321
18Asthma_Homo sapiens_hsa053101.90362320
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86266649
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.85544107
21T cell receptor signaling pathway_Homo sapiens_hsa046601.84151585
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.83836782
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.83206283
24Primary immunodeficiency_Homo sapiens_hsa053401.78352752
25Caffeine metabolism_Homo sapiens_hsa002321.76121222
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.74363075
27Type I diabetes mellitus_Homo sapiens_hsa049401.70676706
28Hematopoietic cell lineage_Homo sapiens_hsa046401.65960183
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.65944504
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.65359286
31Butanoate metabolism_Homo sapiens_hsa006501.63145485
32Measles_Homo sapiens_hsa051621.62980298
33ABC transporters_Homo sapiens_hsa020101.62188852
34Propanoate metabolism_Homo sapiens_hsa006401.61955473
35beta-Alanine metabolism_Homo sapiens_hsa004101.58931355
36Toxoplasmosis_Homo sapiens_hsa051451.58399312
37Influenza A_Homo sapiens_hsa051641.54563469
38Malaria_Homo sapiens_hsa051441.51598810
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.51049600
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49357913
41Staphylococcus aureus infection_Homo sapiens_hsa051501.49229612
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.47126341
43Chemokine signaling pathway_Homo sapiens_hsa040621.44746991
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43077752
45Legionellosis_Homo sapiens_hsa051341.42171665
46TNF signaling pathway_Homo sapiens_hsa046681.40643753
47Antigen processing and presentation_Homo sapiens_hsa046121.39711609
48Jak-STAT signaling pathway_Homo sapiens_hsa046301.37483231
49Peroxisome_Homo sapiens_hsa041461.36202090
50Acute myeloid leukemia_Homo sapiens_hsa052211.35249226
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34632722
52Fatty acid metabolism_Homo sapiens_hsa012121.29565946
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.25614172
54Starch and sucrose metabolism_Homo sapiens_hsa005001.24863863
55Hepatitis B_Homo sapiens_hsa051611.23604056
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.21662421
57Phenylalanine metabolism_Homo sapiens_hsa003601.21140780
58Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21053049
59Viral myocarditis_Homo sapiens_hsa054161.20751549
60Herpes simplex infection_Homo sapiens_hsa051681.19422502
61Non-small cell lung cancer_Homo sapiens_hsa052231.18575087
62Platelet activation_Homo sapiens_hsa046111.18251786
63Vitamin B6 metabolism_Homo sapiens_hsa007501.16977325
64Insulin resistance_Homo sapiens_hsa049311.12856599
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11346365
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11006254
67Drug metabolism - other enzymes_Homo sapiens_hsa009831.09865040
68Renal cell carcinoma_Homo sapiens_hsa052111.09802444
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07720926
70Phagosome_Homo sapiens_hsa041451.07578994
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06330129
72Steroid hormone biosynthesis_Homo sapiens_hsa001401.06132929
73Adipocytokine signaling pathway_Homo sapiens_hsa049201.04370126
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03876957
75Neurotrophin signaling pathway_Homo sapiens_hsa047221.02064937
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.99795868
77Pertussis_Homo sapiens_hsa051330.99652326
78Pancreatic cancer_Homo sapiens_hsa052120.99503567
79Hepatitis C_Homo sapiens_hsa051600.96376434
80Histidine metabolism_Homo sapiens_hsa003400.96039206
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92504923
82Prolactin signaling pathway_Homo sapiens_hsa049170.92273501
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91758569
84Chemical carcinogenesis_Homo sapiens_hsa052040.89626496
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89106027
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87086997
87Retinol metabolism_Homo sapiens_hsa008300.87034364
88Apoptosis_Homo sapiens_hsa042100.85519626
89Circadian rhythm_Homo sapiens_hsa047100.85238749
90Chronic myeloid leukemia_Homo sapiens_hsa052200.84810766
91Glucagon signaling pathway_Homo sapiens_hsa049220.84659910
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83072335
93Selenocompound metabolism_Homo sapiens_hsa004500.82882864
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82182836
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78419331
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77753998
97Notch signaling pathway_Homo sapiens_hsa043300.77687227
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76358539
99VEGF signaling pathway_Homo sapiens_hsa043700.76331801
100Other glycan degradation_Homo sapiens_hsa005110.75522868
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74637204
102Inositol phosphate metabolism_Homo sapiens_hsa005620.74583958
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74405550
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.73648250
105Vitamin digestion and absorption_Homo sapiens_hsa049770.73541580
106Colorectal cancer_Homo sapiens_hsa052100.71141612
107Endometrial cancer_Homo sapiens_hsa052130.71041795
108GABAergic synapse_Homo sapiens_hsa047270.71028565
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70748997
110Dorso-ventral axis formation_Homo sapiens_hsa043200.70685164
111Tyrosine metabolism_Homo sapiens_hsa003500.70513116
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68725179
113* Choline metabolism in cancer_Homo sapiens_hsa052310.66912801
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.66353540
115Salmonella infection_Homo sapiens_hsa051320.66173231
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65579332
117MAPK signaling pathway_Homo sapiens_hsa040100.64944688
118Shigellosis_Homo sapiens_hsa051310.64658609
119Morphine addiction_Homo sapiens_hsa050320.64507337
120Dilated cardiomyopathy_Homo sapiens_hsa054140.62959941
121Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62672840
122Circadian entrainment_Homo sapiens_hsa047130.62015962
123ErbB signaling pathway_Homo sapiens_hsa040120.61968647
124B cell receptor signaling pathway_Homo sapiens_hsa046620.61643881
125Olfactory transduction_Homo sapiens_hsa047400.60852051
126Oxytocin signaling pathway_Homo sapiens_hsa049210.59407461
127mTOR signaling pathway_Homo sapiens_hsa041500.58605596
128Cysteine and methionine metabolism_Homo sapiens_hsa002700.58465776
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58356612
130Glutamatergic synapse_Homo sapiens_hsa047240.57731113
131Ovarian steroidogenesis_Homo sapiens_hsa049130.57154582
132Epstein-Barr virus infection_Homo sapiens_hsa051690.56519644
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56217766
134Prostate cancer_Homo sapiens_hsa052150.55524778
135Glycerolipid metabolism_Homo sapiens_hsa005610.55411421
136Insulin signaling pathway_Homo sapiens_hsa049100.54872320
137Gastric acid secretion_Homo sapiens_hsa049710.54572892
138Pyruvate metabolism_Homo sapiens_hsa006200.54019118
139Lysosome_Homo sapiens_hsa041420.53931180
140Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53697093
141Viral carcinogenesis_Homo sapiens_hsa052030.52285932
142Carbon metabolism_Homo sapiens_hsa012000.51622302
143Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51199782
144AMPK signaling pathway_Homo sapiens_hsa041520.49929593
145HTLV-I infection_Homo sapiens_hsa051660.49880852
146Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49516966
147Estrogen signaling pathway_Homo sapiens_hsa049150.48135899
148Lysine degradation_Homo sapiens_hsa003100.47886231
149Calcium signaling pathway_Homo sapiens_hsa040200.47722152
150Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47626115
151HIF-1 signaling pathway_Homo sapiens_hsa040660.47487807
152Renin secretion_Homo sapiens_hsa049240.46989369
153Amoebiasis_Homo sapiens_hsa051460.46818378
154Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45471697
155Fat digestion and absorption_Homo sapiens_hsa049750.44916589
156Salivary secretion_Homo sapiens_hsa049700.44176536
157Type II diabetes mellitus_Homo sapiens_hsa049300.42904587
158Cholinergic synapse_Homo sapiens_hsa047250.42875021
159Biosynthesis of amino acids_Homo sapiens_hsa012300.41230273
160Fatty acid biosynthesis_Homo sapiens_hsa000610.40704391
161Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40594648
162Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40448251
163Osteoclast differentiation_Homo sapiens_hsa043800.40339119
164Glioma_Homo sapiens_hsa052140.40256021
165Endocytosis_Homo sapiens_hsa041440.40092102
166cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38860339
167Arginine and proline metabolism_Homo sapiens_hsa003300.38518222
168FoxO signaling pathway_Homo sapiens_hsa040680.38088281
169Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37880307
170* Glycerophospholipid metabolism_Homo sapiens_hsa005640.36443153
171Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35583435
172cAMP signaling pathway_Homo sapiens_hsa040240.35219164
173Long-term potentiation_Homo sapiens_hsa047200.34780144
174GnRH signaling pathway_Homo sapiens_hsa049120.34168153
175Taste transduction_Homo sapiens_hsa047420.33059843
176Insulin secretion_Homo sapiens_hsa049110.32574764
177Rheumatoid arthritis_Homo sapiens_hsa053230.31247396
178Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30803134
179Vascular smooth muscle contraction_Homo sapiens_hsa042700.30301557
180Regulation of autophagy_Homo sapiens_hsa041400.28067788
181African trypanosomiasis_Homo sapiens_hsa051430.27653662

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