GPC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma lipoprotein particle assembly (GO:0034377)8.52058099
2very-low-density lipoprotein particle assembly (GO:0034379)8.41362509
3negative regulation of fibrinolysis (GO:0051918)7.68884511
4protein-lipid complex assembly (GO:0065005)7.52711757
5low-density lipoprotein particle remodeling (GO:0034374)7.30202505
6regulation of cholesterol esterification (GO:0010872)7.08630441
7peptidyl-glutamic acid carboxylation (GO:0017187)6.78762049
8protein carboxylation (GO:0018214)6.78762049
9regulation of fibrinolysis (GO:0051917)6.60441067
10intestinal cholesterol absorption (GO:0030299)6.43417402
11regulation of protein activation cascade (GO:2000257)6.42335727
12protein-lipid complex remodeling (GO:0034368)6.41226622
13macromolecular complex remodeling (GO:0034367)6.41226622
14plasma lipoprotein particle remodeling (GO:0034369)6.41226622
15cholesterol efflux (GO:0033344)6.39248930
16regulation of complement activation (GO:0030449)6.19060386
17high-density lipoprotein particle remodeling (GO:0034375)6.09531960
18plasma lipoprotein particle organization (GO:0071827)6.02858446
19regulation of apoptotic cell clearance (GO:2000425)5.84664323
20plasma lipoprotein particle clearance (GO:0034381)5.73329554
21blood coagulation, intrinsic pathway (GO:0007597)5.65800216
22protein-lipid complex subunit organization (GO:0071825)5.63772541
23reverse cholesterol transport (GO:0043691)5.58205573
24triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.44797265
25regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.41188389
26negative regulation of cholesterol transport (GO:0032375)4.96498571
27negative regulation of sterol transport (GO:0032372)4.96498571
28phospholipid efflux (GO:0033700)4.91514395
29regulation of plasminogen activation (GO:0010755)4.83738133
30paraxial mesoderm development (GO:0048339)4.77742124
31positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.77536456
32erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.65855219
33L-phenylalanine catabolic process (GO:0006559)4.65855219
34bone trabecula formation (GO:0060346)4.65673271
35negative regulation of protein activation cascade (GO:2000258)4.64321293
36regulation of bile acid biosynthetic process (GO:0070857)4.61686935
37notochord development (GO:0030903)4.56440565
38erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.36942718
39L-phenylalanine metabolic process (GO:0006558)4.36942718
40regulation of cholesterol homeostasis (GO:2000188)4.34332681
41intestinal absorption (GO:0050892)4.34167482
42diacylglycerol metabolic process (GO:0046339)4.20443908
43low-density lipoprotein particle clearance (GO:0034383)4.16836299
44protein localization to kinetochore (GO:0034501)4.16306043
45lipoprotein metabolic process (GO:0042157)4.13967896
46complement activation, alternative pathway (GO:0006957)4.10647265
47regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.07090758
48embryonic skeletal joint morphogenesis (GO:0060272)4.02527648
49cholesterol homeostasis (GO:0042632)3.98974692
50regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.96509888
51sterol homeostasis (GO:0055092)3.95223443
52regulation of cholesterol biosynthetic process (GO:0045540)3.93995513
53lung epithelium development (GO:0060428)3.91850916
54cholesterol transport (GO:0030301)3.89987908
55sterol transport (GO:0015918)3.89987908
56proline metabolic process (GO:0006560)3.89911466
57negative regulation of lipase activity (GO:0060192)3.89840133
58planar cell polarity pathway involved in neural tube closure (GO:0090179)3.85603664
59mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.84644439
60embryonic retina morphogenesis in camera-type eye (GO:0060059)3.78465082
61negative regulation of epidermis development (GO:0045683)3.71558394
62DNA unwinding involved in DNA replication (GO:0006268)3.70571645
63positive regulation of steroid metabolic process (GO:0045940)3.68834084
64regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.60578134
65proximal/distal pattern formation (GO:0009954)3.58721253
66negative regulation of complement activation (GO:0045916)3.56655094
67outer ear morphogenesis (GO:0042473)3.51259402
68polarized epithelial cell differentiation (GO:0030859)3.49045463
69negative regulation of sodium ion transport (GO:0010766)3.47946611
70lateral sprouting from an epithelium (GO:0060601)3.46957156
71fibrinolysis (GO:0042730)3.45342973
72metanephric mesenchyme development (GO:0072075)3.44213095
73negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.42962186
74acylglycerol homeostasis (GO:0055090)3.40762245
75triglyceride homeostasis (GO:0070328)3.40762245
76positive regulation of hemostasis (GO:1900048)3.40238569
77positive regulation of blood coagulation (GO:0030194)3.40238569
78positive regulation of triglyceride lipase activity (GO:0061365)3.40032312
79positive regulation of lipoprotein lipase activity (GO:0051006)3.40032312
80glutamate metabolic process (GO:0006536)3.39395061
81positive regulation of extracellular matrix organization (GO:1903055)3.35091186
82proline biosynthetic process (GO:0006561)3.35020216
83negative regulation of hemostasis (GO:1900047)3.34964804
84negative regulation of blood coagulation (GO:0030195)3.34964804
85kidney mesenchyme development (GO:0072074)3.33301240
86positive regulation of hormone metabolic process (GO:0032352)3.33175938
87uterus development (GO:0060065)3.32795412
88regulation of humoral immune response (GO:0002920)3.31232661
89nuclear pore complex assembly (GO:0051292)3.30465432
90sister chromatid segregation (GO:0000819)3.29726839
91negative regulation of norepinephrine secretion (GO:0010700)3.29637670
92acylglycerol catabolic process (GO:0046464)3.28872305
93neutral lipid catabolic process (GO:0046461)3.28872305
94acute-phase response (GO:0006953)3.28816073
95head development (GO:0060322)3.27762839
96nuclear pore organization (GO:0006999)3.27367703
97DNA replication-dependent nucleosome assembly (GO:0006335)3.26548424
98DNA replication-dependent nucleosome organization (GO:0034723)3.26548424
99protein activation cascade (GO:0072376)3.24651009
100lipoprotein transport (GO:0042953)3.24376411
101pre-miRNA processing (GO:0031054)3.24324272
102mitotic sister chromatid segregation (GO:0000070)3.24072137
103G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.23948257
104lipid homeostasis (GO:0055088)3.20480541
105positive regulation of hormone biosynthetic process (GO:0046886)3.19022840
106regulation of stem cell maintenance (GO:2000036)3.17480043
107heterochromatin organization (GO:0070828)3.17200703
108positive regulation of DNA-dependent DNA replication (GO:2000105)3.14867737
109protein localization to chromosome, centromeric region (GO:0071459)3.13947403
110mitotic chromosome condensation (GO:0007076)3.13705095
1114-hydroxyproline metabolic process (GO:0019471)3.10667581
112negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.09577376
113positive regulation of coagulation (GO:0050820)3.09527663
114polyketide metabolic process (GO:0030638)3.09503270
115doxorubicin metabolic process (GO:0044598)3.09503270
116daunorubicin metabolic process (GO:0044597)3.09503270
117negative regulation of coagulation (GO:0050819)3.09235849
118hippo signaling (GO:0035329)3.08667090
119response to prostaglandin (GO:0034694)3.08489843
120organ induction (GO:0001759)3.06069129
121modified amino acid transport (GO:0072337)3.05734135
122negative regulation of DNA repair (GO:0045738)3.05227119
123mesenchymal to epithelial transition (GO:0060231)3.04480092
124respiratory tube development (GO:0030323)3.03456354
125regulation of norepinephrine secretion (GO:0014061)3.02852916
126positive regulation of fatty acid biosynthetic process (GO:0045723)3.02280518
127mesonephros development (GO:0001823)3.02267332
128mesenchyme development (GO:0060485)3.00343235
129dicarboxylic acid biosynthetic process (GO:0043650)2.99804075
130peptidyl-glutamic acid modification (GO:0018200)2.99457438
131positive regulation of dendritic spine morphogenesis (GO:0061003)2.98671066
132regulation of heterotypic cell-cell adhesion (GO:0034114)2.98230027
133regulation of apoptotic process involved in morphogenesis (GO:1902337)2.96539761
134phosphate ion homeostasis (GO:0055062)2.94427807
135trivalent inorganic anion homeostasis (GO:0072506)2.94427807
136C21-steroid hormone metabolic process (GO:0008207)2.93098024
137renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.92827501
138negative regulation of wound healing (GO:0061045)2.91900664
139vitamin transmembrane transport (GO:0035461)2.91417029
140regulation of cholesterol metabolic process (GO:0090181)2.90783576
141response to vitamin A (GO:0033189)2.89957621
142L-ascorbic acid metabolic process (GO:0019852)2.89928586
143regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.89393764
144regulation of nuclear cell cycle DNA replication (GO:0033262)2.89175968
145mesenchymal cell differentiation involved in kidney development (GO:0072161)2.87977660
146mesenchymal cell differentiation involved in renal system development (GO:2001012)2.87977660
147pinocytosis (GO:0006907)2.87697299
148regulation of extracellular matrix organization (GO:1903053)2.87050019
149negative regulation of chondrocyte differentiation (GO:0032331)2.86884995
150embryonic forelimb morphogenesis (GO:0035115)2.85423230
151regulation of telomere maintenance via telomerase (GO:0032210)2.85419334
152cell migration involved in heart development (GO:0060973)2.84969177
153mesenchyme morphogenesis (GO:0072132)2.83802160
154Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.80407160
155midgut development (GO:0007494)2.79605298
156chondrocyte proliferation (GO:0035988)2.76052782
157negative regulation of cell cycle G2/M phase transition (GO:1902750)2.75026987
158endocardial cushion development (GO:0003197)2.74944691
159convergent extension (GO:0060026)2.74882326
160establishment of apical/basal cell polarity (GO:0035089)2.74558862
161* hindlimb morphogenesis (GO:0035137)2.72996284
162regulation of mammary gland epithelial cell proliferation (GO:0033599)2.72793046
163regulation of heart morphogenesis (GO:2000826)2.72776008
164adrenal gland development (GO:0030325)2.72744176
165forelimb morphogenesis (GO:0035136)2.71733858
166middle ear morphogenesis (GO:0042474)2.71730215
167somite rostral/caudal axis specification (GO:0032525)2.71420577
168prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.70337554
169lung vasculature development (GO:0060426)2.70333359
170regulation of establishment of planar polarity (GO:0090175)2.69747990
171positive regulation of SMAD protein import into nucleus (GO:0060391)2.69512422
172chromatin assembly (GO:0031497)2.68897165
173non-canonical Wnt signaling pathway (GO:0035567)2.68538222
174mRNA stabilization (GO:0048255)2.67847587
175RNA stabilization (GO:0043489)2.67847587
176regulation of organ formation (GO:0003156)2.67704574
177embryonic skeletal system morphogenesis (GO:0048704)2.66570459
178primitive streak formation (GO:0090009)2.66386683
179organ formation (GO:0048645)2.64706506
180regulation of double-strand break repair (GO:2000779)2.63457279
181lung-associated mesenchyme development (GO:0060484)2.63424211
182embryonic foregut morphogenesis (GO:0048617)2.63287734
183cochlea morphogenesis (GO:0090103)2.62879290
184metanephros development (GO:0001656)2.62820612
185glucocorticoid receptor signaling pathway (GO:0042921)2.62270833
186* mesenchymal cell proliferation (GO:0010463)2.59552426
187negative regulation of cartilage development (GO:0061037)2.57795727
188regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.57469486
189outflow tract septum morphogenesis (GO:0003148)2.57373692
190kinetochore organization (GO:0051383)2.55997780
191regulation of SMAD protein import into nucleus (GO:0060390)2.55123779
192regulation of transforming growth factor beta2 production (GO:0032909)2.54698449
193mitotic metaphase plate congression (GO:0007080)2.54536181
194embryonic digit morphogenesis (GO:0042733)2.54439896
195axon extension involved in axon guidance (GO:0048846)2.53263977
196neuron projection extension involved in neuron projection guidance (GO:1902284)2.53263977
197anterior/posterior axis specification, embryo (GO:0008595)2.53047334
198chromosome condensation (GO:0030261)2.52731389
199regulation of mesoderm development (GO:2000380)2.52445702

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.74578597
2E2F7_22180533_ChIP-Seq_HELA_Human7.53816378
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.52867058
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.46040177
5FOXA2_19822575_ChIP-Seq_HepG2_Human4.35716225
6TP63_19390658_ChIP-ChIP_HaCaT_Human4.28807615
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.25778103
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.94758765
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.94758765
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.94758765
11LXR_22158963_ChIP-Seq_LIVER_Mouse3.83729552
12PPARA_22158963_ChIP-Seq_LIVER_Mouse3.80674678
13E2F4_17652178_ChIP-ChIP_JURKAT_Human3.63925733
14CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.59338506
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.32725610
16RBPJ_22232070_ChIP-Seq_NCS_Mouse3.26077222
17* HNF4A_19822575_ChIP-Seq_HepG2_Human3.11594017
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.06228375
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.93456608
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.83397609
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.77795446
22ZNF263_19887448_ChIP-Seq_K562_Human2.76986673
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.73141854
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.67260935
25EGR1_23403033_ChIP-Seq_LIVER_Mouse2.57416782
26ESR1_15608294_ChIP-ChIP_MCF-7_Human2.55875155
27FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.42392314
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.30081149
29AR_21909140_ChIP-Seq_LNCAP_Human2.29572929
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.27584542
31BP1_19119308_ChIP-ChIP_Hs578T_Human2.24482354
32SALL4_18804426_ChIP-ChIP_XEN_Mouse2.19914858
33SALL1_21062744_ChIP-ChIP_HESCs_Human2.15455848
34TCF3_18692474_ChIP-Seq_MEFs_Mouse2.10184296
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.02778133
36EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.02562940
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.99984239
38TCF4_18268006_ChIP-ChIP_LS174T_Human1.99624031
39SOX2_18555785_ChIP-Seq_MESCs_Mouse1.98009531
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.95720701
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.95644423
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.94785453
43SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.94233597
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93186523
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.91863778
46HIF1A_21447827_ChIP-Seq_MCF-7_Human1.88077279
47SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.84225302
48TCF3_18692474_ChIP-Seq_MESCs_Mouse1.84080551
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.82316075
50* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.80649375
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79573013
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.78643615
53SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.78589929
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.77198635
55WT1_19549856_ChIP-ChIP_CCG9911_Human1.76168643
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.73268587
57TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.72181699
58KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.70008061
59NANOG_16153702_ChIP-ChIP_HESCs_Human1.69561959
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.66919982
61NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.65548369
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.64568423
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59535613
64GATA4_25053715_ChIP-Seq_YYC3_Human1.59470608
65* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.59463582
66ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.58159678
67NANOG_21062744_ChIP-ChIP_HESCs_Human1.55410505
68CDX2_20551321_ChIP-Seq_CACO-2_Human1.53914217
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.53056773
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.50172817
71* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.49009627
72NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.48851918
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46886615
74KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.42543199
75SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.38250627
76SOX2_16153702_ChIP-ChIP_HESCs_Human1.37803611
77TP63_17297297_ChIP-ChIP_HaCaT_Human1.37009939
78* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.36448430
79ZFP281_27345836_Chip-Seq_ESCs_Mouse1.35388649
80XRN2_22483619_ChIP-Seq_HELA_Human1.35367436
81NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35015499
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34767370
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34510210
84FOXO3_23340844_ChIP-Seq_DLD1_Human1.33858158
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33695328
86TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.32852447
87E2F1_21310950_ChIP-Seq_MCF-7_Human1.31528950
88TP53_20018659_ChIP-ChIP_R1E_Mouse1.29698117
89GATA6_25053715_ChIP-Seq_YYC3_Human1.26143261
90ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20983430
91ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19911250
92EST1_17652178_ChIP-ChIP_JURKAT_Human1.19267954
93TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19252079
94* ISL1_27105846_Chip-Seq_CPCs_Mouse1.18301118
95NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17775767
96* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.17335752
97SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.16059626
98NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14788555
99NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.14436976
100POU5F1_16518401_ChIP-PET_MESCs_Mouse1.14370326
101TTF2_22483619_ChIP-Seq_HELA_Human1.12911191
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12331306
103CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11119798
104DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10197868
105E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10165831
106SOX2_18692474_ChIP-Seq_MEFs_Mouse1.09233185
107GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.06478113
108PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.06391317
109FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03958928
110POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03182378
111CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02399528
112YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01999924
113PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00212896
114PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99934306
115MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99003905
116AR_21572438_ChIP-Seq_LNCaP_Human0.96867589
117OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96863879
118POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.95573791
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95502726
120SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94959801
121NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94684323
122PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94481413
123SOX17_20123909_ChIP-Seq_XEN_Mouse0.94464314
124ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93658825
125HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.93068396
126MYC_22102868_ChIP-Seq_BL_Human0.92343054
127* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91681459
128NANOG_18692474_ChIP-Seq_MEFs_Mouse0.91334399
129RING1B_27294783_Chip-Seq_NPCs_Mouse0.89979890
130ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89682362
131CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89474339
132TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89441314
133SOX2_18692474_ChIP-Seq_MESCs_Mouse0.89329212
134DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88998592
135CLOCK_20551151_ChIP-Seq_293T_Human0.88972130
136PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88536049
137BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88504338
138* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.87053094
139TBX3_20139965_ChIP-Seq_ESCs_Mouse0.86800982
140CHD1_26751641_Chip-Seq_LNCaP_Human0.85465017
141TBX3_20139965_ChIP-Seq_MESCs_Mouse0.85401360
142EOMES_21245162_ChIP-Seq_HESCs_Human0.85199582
143FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84293687
144RXRA_24833708_ChIP-Seq_LIVER_Mouse0.80336168
145KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79161058
146SOX11_22085726_ChIP-Seq_ESNs_Mouse0.78692283
147RARA_24833708_ChIP-Seq_LIVER_Mouse0.77110605
148STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.76828120
149EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.74716343
150EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.73786609
151PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.73026519
152KAP1_27257070_Chip-Seq_ESCs_Mouse0.72669746
153TRIM28_21343339_ChIP-Seq_HEK293_Human0.66721549
154ERG_21242973_ChIP-ChIP_JURKAT_Human0.66648599

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.85880844
2MP0005360_urolithiasis4.30027504
3MP0005365_abnormal_bile_salt4.04820525
4MP0003195_calcinosis4.04323587
5* MP0003122_maternal_imprinting3.98547524
6MP0010030_abnormal_orbit_morphology3.67649757
7MP0010329_abnormal_lipoprotein_level3.55139559
8MP0001666_abnormal_nutrient_absorption3.44379634
9* MP0003123_paternal_imprinting3.27064781
10* MP0003121_genomic_imprinting3.20724746
11MP0005085_abnormal_gallbladder_physiolo3.01768369
12MP0009053_abnormal_anal_canal2.88936156
13MP0002089_abnormal_postnatal_growth/wei2.59988967
14MP0005408_hypopigmentation2.48315437
15* MP0003942_abnormal_urinary_system2.44082046
16* MP0003385_abnormal_body_wall2.34210387
17MP0000537_abnormal_urethra_morphology2.28234238
18MP0004272_abnormal_basement_membrane2.28007528
19MP0002249_abnormal_larynx_morphology2.22375814
20MP0008875_abnormal_xenobiotic_pharmacok2.19793146
21MP0003868_abnormal_feces_composition2.19714246
22MP0001915_intracranial_hemorrhage2.15729685
23MP0000049_abnormal_middle_ear2.14808997
24MP0003705_abnormal_hypodermis_morpholog2.14808643
25MP0009250_abnormal_appendicular_skeleto2.13458267
26MP0003941_abnormal_skin_development2.09679865
27MP0005503_abnormal_tendon_morphology2.09117436
28MP0002932_abnormal_joint_morphology2.04993999
29MP0000534_abnormal_ureter_morphology2.03817327
30MP0003937_abnormal_limbs/digits/tail_de1.99918748
31MP0004264_abnormal_extraembryonic_tissu1.96039404
32MP0008438_abnormal_cutaneous_collagen1.95393312
33MP0003119_abnormal_digestive_system1.95351840
34MP0004957_abnormal_blastocyst_morpholog1.94051416
35MP0003252_abnormal_bile_duct1.81149099
36MP0003890_abnormal_embryonic-extraembry1.79821420
37MP0008057_abnormal_DNA_replication1.77548774
38MP0002282_abnormal_trachea_morphology1.73985573
39MP0000428_abnormal_craniofacial_morphol1.72450036
40MP0003115_abnormal_respiratory_system1.70418068
41MP0003567_abnormal_fetal_cardiomyocyte1.68391866
42MP0003935_abnormal_craniofacial_develop1.68137987
43MP0001293_anophthalmia1.67171230
44MP0004197_abnormal_fetal_growth/weight/1.66977560
45MP0003755_abnormal_palate_morphology1.65689493
46MP0005248_abnormal_Harderian_gland1.62988669
47MP0005058_abnormal_lysosome_morphology1.62777816
48MP0003787_abnormal_imprinting1.61408195
49MP0003938_abnormal_ear_development1.58750917
50MP0001672_abnormal_embryogenesis/_devel1.56721738
51MP0005380_embryogenesis_phenotype1.56721738
52MP0009840_abnormal_foam_cell1.55737998
53MP0006054_spinal_hemorrhage1.53748076
54MP0010368_abnormal_lymphatic_system1.53335696
55MP0000566_synostosis1.53115541
56MP0002088_abnormal_embryonic_growth/wei1.50885537
57MP0005508_abnormal_skeleton_morphology1.50246339
58MP0003878_abnormal_ear_physiology1.50115478
59MP0005377_hearing/vestibular/ear_phenot1.50115478
60MP0003077_abnormal_cell_cycle1.49887186
61MP0002085_abnormal_embryonic_tissue1.49247671
62MP0000762_abnormal_tongue_morphology1.48872509
63MP0003984_embryonic_growth_retardation1.48453089
64MP0002233_abnormal_nose_morphology1.46227635
65MP0003172_abnormal_lysosome_physiology1.45943264
66MP0002132_abnormal_respiratory_system1.44459521
67MP0000609_abnormal_liver_physiology1.43205116
68MP0000678_abnormal_parathyroid_gland1.39251591
69MP0009780_abnormal_chondrocyte_physiolo1.35805282
70MP0002084_abnormal_developmental_patter1.34966717
71MP0002118_abnormal_lipid_homeostasis1.34964192
72MP0000432_abnormal_head_morphology1.34004047
73MP0000516_abnormal_urinary_system1.33472965
74MP0005367_renal/urinary_system_phenotyp1.33472965
75MP0005623_abnormal_meninges_morphology1.30759179
76MP0008932_abnormal_embryonic_tissue1.30449037
77* MP0002109_abnormal_limb_morphology1.30303400
78MP0010094_abnormal_chromosome_stability1.29655627
79MP0005332_abnormal_amino_acid1.29418362
80* MP0002114_abnormal_axial_skeleton1.29240215
81MP0003111_abnormal_nucleus_morphology1.28387432
82MP0000639_abnormal_adrenal_gland1.27964271
83MP0002111_abnormal_tail_morphology1.25643650
84MP0005409_darkened_coat_color1.25403915
85* MP0002086_abnormal_extraembryonic_tissu1.24593156
86* MP0002116_abnormal_craniofacial_bone1.23895151
87MP0002127_abnormal_cardiovascular_syste1.22932908
88MP0009697_abnormal_copulation1.22709968
89MP0005257_abnormal_intraocular_pressure1.21920174
90MP0001286_abnormal_eye_development1.19493157
91MP0001661_extended_life_span1.19343473
92MP0006292_abnormal_olfactory_placode1.17760202
93MP0005275_abnormal_skin_tensile1.16883125
94MP0001849_ear_inflammation1.16742068
95MP0008007_abnormal_cellular_replicative1.16711848
96* MP0001697_abnormal_embryo_size1.16711069
97MP0003693_abnormal_embryo_hatching1.15358394
98MP0009703_decreased_birth_body1.15161253
99MP0003011_delayed_dark_adaptation1.14216546
100MP0004019_abnormal_vitamin_homeostasis1.13608358
101MP0002092_abnormal_eye_morphology1.13025232
102MP0000163_abnormal_cartilage_morphology1.11713106
103MP0000350_abnormal_cell_proliferation1.11497220
104MP0003283_abnormal_digestive_organ1.10578021
105MP0003136_yellow_coat_color1.10502725
106* MP0002938_white_spotting1.09859702
107MP0005451_abnormal_body_composition1.09800557
108MP0003950_abnormal_plasma_membrane1.08391707
109MP0001730_embryonic_growth_arrest1.06991054
110* MP0002925_abnormal_cardiovascular_devel1.06482204
111MP0005084_abnormal_gallbladder_morpholo1.03777342
112MP0005167_abnormal_blood-brain_barrier1.02709395
113MP0000733_abnormal_muscle_development1.02139608
114MP0001324_abnormal_eye_pigmentation1.01829790
115MP0009672_abnormal_birth_weight1.01703550
116MP0000598_abnormal_liver_morphology1.01582594
117MP0000767_abnormal_smooth_muscle1.00666579
118MP0005076_abnormal_cell_differentiation0.99563748
119MP0002933_joint_inflammation0.93550988
120MP0002697_abnormal_eye_size0.92315705
121MP0001299_abnormal_eye_distance/0.91731912
122MP0005636_abnormal_mineral_homeostasis0.91214421
123MP0002080_prenatal_lethality0.90517186
124MP0002108_abnormal_muscle_morphology0.90093793
125MP0010352_gastrointestinal_tract_polyps0.89520107
126MP0005394_taste/olfaction_phenotype0.89248449
127MP0005499_abnormal_olfactory_system0.89248449
128* MP0002115_abnormal_skeleton_extremities0.84730459
129MP0009384_cardiac_valve_regurgitation0.84666434
130MP0000604_amyloidosis0.84553967
131* MP0000266_abnormal_heart_morphology0.84288643
132MP0010630_abnormal_cardiac_muscle0.83838720
133MP0003943_abnormal_hepatobiliary_system0.83354880
134* MP0001175_abnormal_lung_morphology0.82544782
135MP0003279_aneurysm0.82528313
136MP0004133_heterotaxia0.82080429
137* MP0002081_perinatal_lethality0.80607295
138MP0002653_abnormal_ependyma_morphology0.79684773
139MP0005379_endocrine/exocrine_gland_phen0.77227142
140MP0006138_congestive_heart_failure0.76806161
141MP0005220_abnormal_exocrine_pancreas0.76235210
142* MP0002113_abnormal_skeleton_development0.75398219
143MP0001764_abnormal_homeostasis0.74269836
144MP0003632_abnormal_nervous_system0.74092142
145MP0003861_abnormal_nervous_system0.73988182
146MP0002876_abnormal_thyroid_physiology0.69643141
147MP0003566_abnormal_cell_adhesion0.66515323
148MP0001346_abnormal_lacrimal_gland0.66439141
149MP0000003_abnormal_adipose_tissue0.60695237
150MP0001529_abnormal_vocalization0.60682100
151MP0005670_abnormal_white_adipose0.60603464
152MP0005410_abnormal_fertilization0.60245168
153* MP0009642_abnormal_blood_homeostasis0.58452359
154MP0005391_vision/eye_phenotype0.56738914
155MP0002909_abnormal_adrenal_gland0.56098575
156MP0002128_abnormal_blood_circulation0.56029247
157MP0003329_amyloid_beta_deposits0.54220694
158MP0009115_abnormal_fat_cell0.52995368
159MP0005551_abnormal_eye_electrophysiolog0.52313837

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)7.09216739
2Hypobetalipoproteinemia (HP:0003563)6.41275998
3Joint hemorrhage (HP:0005261)5.70951864
4Abnormality of the common coagulation pathway (HP:0010990)5.51171596
5Complement deficiency (HP:0004431)4.93985657
6Small epiphyses (HP:0010585)4.55397267
7Bilateral microphthalmos (HP:0007633)4.45026956
8Short 4th metacarpal (HP:0010044)4.31846583
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.31846583
10Hypercholesterolemia (HP:0003124)4.27664092
11Hypolipoproteinemia (HP:0010981)4.22230330
12Spontaneous abortion (HP:0005268)4.19171632
13Xanthomatosis (HP:0000991)4.14712912
14Acanthocytosis (HP:0001927)4.13352862
15Abnormal tarsal ossification (HP:0008369)4.09038337
16Glomerulonephritis (HP:0000099)4.06049174
17* Hepatoblastoma (HP:0002884)3.72151903
18Abnormal lung lobation (HP:0002101)3.69872211
19Abnormality of the 4th metacarpal (HP:0010012)3.65569023
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.61381917
21Irregular epiphyses (HP:0010582)3.55597670
22Menorrhagia (HP:0000132)3.50307537
23Abnormality of complement system (HP:0005339)3.48585123
24Flat acetabular roof (HP:0003180)3.45280700
25Epidermoid cyst (HP:0200040)3.39381460
26Epiphyseal dysplasia (HP:0002656)3.38789427
27Hemorrhage of the eye (HP:0011885)3.29820004
28* Nephroblastoma (Wilms tumor) (HP:0002667)3.26448926
29Abnormality of the phalanges of the hallux (HP:0010057)3.24374800
30Hypoplasia of the capital femoral epiphysis (HP:0003090)3.23325099
31Bifid tongue (HP:0010297)3.22865101
32* Embryonal renal neoplasm (HP:0011794)3.17938122
33Absent epiphyses (HP:0010577)3.15652516
34Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.15652516
35Abnormality of the nasal septum (HP:0000419)3.09220344
36Short middle phalanx of the 5th finger (HP:0004220)3.08528505
37Short 5th finger (HP:0009237)3.07410701
38Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.02713012
39Systemic lupus erythematosus (HP:0002725)2.96608540
40Vaginal fistula (HP:0004320)2.95248784
41* Renal duplication (HP:0000075)2.93427850
42Abnormality of the distal phalanx of the thumb (HP:0009617)2.91632337
43Mesomelia (HP:0003027)2.85969051
44Abnormality of the lumbar spine (HP:0100712)2.85778221
45Alacrima (HP:0000522)2.79238951
46Protrusio acetabuli (HP:0003179)2.78346157
47Rib fusion (HP:0000902)2.77447522
48Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.75976491
49Partial duplication of the phalanx of hand (HP:0009999)2.74211846
50Shawl scrotum (HP:0000049)2.72944979
51Arthropathy (HP:0003040)2.69454382
52Intrahepatic cholestasis (HP:0001406)2.68804786
53Abnormal foot bone ossification (HP:0010675)2.68111303
54Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.67424309
55Hypoalphalipoproteinemia (HP:0003233)2.67271865
56Abnormal umbilical cord blood vessels (HP:0011403)2.65762332
57Single umbilical artery (HP:0001195)2.65762332
58Abnormality of the fetal cardiovascular system (HP:0010948)2.65762332
59Abnormal pancreas size (HP:0012094)2.64452168
60Increased serum pyruvate (HP:0003542)2.63646013
61Midline defect of the nose (HP:0004122)2.58719745
62Hypophosphatemic rickets (HP:0004912)2.58407510
63Osteomalacia (HP:0002749)2.57529989
64Limited elbow extension (HP:0001377)2.57008594
65Vascular calcification (HP:0004934)2.56335044
66Gingival bleeding (HP:0000225)2.55623241
67Hypoglycemic coma (HP:0001325)2.52149164
68Abnormality of glycolysis (HP:0004366)2.50690880
69Selective tooth agenesis (HP:0001592)2.47477418
70Shallow orbits (HP:0000586)2.47453606
71Atresia of the external auditory canal (HP:0000413)2.45113673
72Abnormality of monocarboxylic acid metabolism (HP:0010996)2.44222896
73Abnormality of the nasolacrimal system (HP:0000614)2.38324681
74Cupped ribs (HP:0000887)2.38270821
75Fat malabsorption (HP:0002630)2.35053346
76Preaxial foot polydactyly (HP:0001841)2.34967357
77Spinal cord lesions (HP:0100561)2.34406686
78Syringomyelia (HP:0003396)2.34406686
79Aplasia/Hypoplasia of the sternum (HP:0006714)2.34232666
80Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.32216652
81Abnormality of the parietal bone (HP:0002696)2.31984606
82Hypochromic microcytic anemia (HP:0004840)2.31908637
83Asymmetry of the thorax (HP:0001555)2.31467756
84Wide nose (HP:0000445)2.30957629
85Cutaneous finger syndactyly (HP:0010554)2.25414973
86Short humerus (HP:0005792)2.24979689
87Cardiovascular calcification (HP:0011915)2.24522976
88* Broad palm (HP:0001169)2.23868596
89Aplasia/hypoplasia of the humerus (HP:0006507)2.23386353
90Abnormal number of incisors (HP:0011064)2.22450720
91Hepatocellular carcinoma (HP:0001402)2.22222954
92Abnormality of the lacrimal duct (HP:0011481)2.21905134
93Multiple enchondromatosis (HP:0005701)2.21859439
94Hyperglycinemia (HP:0002154)2.21758438
95Ependymoma (HP:0002888)2.21263912
96Purpura (HP:0000979)2.21096728
97Skin nodule (HP:0200036)2.20543291
98Thrombophlebitis (HP:0004418)2.19256929
99Abnormality of the acetabulum (HP:0003170)2.19251114
100Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.18661398
101* Broad toe (HP:0001837)2.16631530
102Mitral stenosis (HP:0001718)2.14623320
103Abnormality of the intrinsic pathway (HP:0010989)2.13888238
104Medulloblastoma (HP:0002885)2.13678029
105Impaired pain sensation (HP:0007328)2.12966731
106Abnormality of pain sensation (HP:0010832)2.12966731
107Neoplasm of striated muscle (HP:0009728)2.11713326
108Increased nuchal translucency (HP:0010880)2.11436416
109Wide anterior fontanel (HP:0000260)2.11088939
110Decreased lacrimation (HP:0000633)2.09360417
111Potter facies (HP:0002009)2.08661991
112Facial shape deformation (HP:0011334)2.08661991
113Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.07201422
114Cutaneous syndactyly (HP:0012725)2.07000660
115Partial duplication of thumb phalanx (HP:0009944)2.03990552
116* Abnormality of carpal bone ossification (HP:0006257)2.02059236
117Dislocated radial head (HP:0003083)2.01629339
118Abnormality of the pubic bones (HP:0003172)2.01140414
119* Broad thumb (HP:0011304)2.01097745
120Deep venous thrombosis (HP:0002625)10.3306715
121* Diastasis recti (HP:0001540)1.99741824
122Colon cancer (HP:0003003)1.99539878
123Prenatal maternal abnormality (HP:0002686)1.98763656
124Abnormality of the phalanges of the 5th finger (HP:0004213)1.97369435
125Abnormality of the pulmonary veins (HP:0011718)1.96970949
126Abnormal delivery (HP:0001787)1.96912310
127Abnormality of the radial head (HP:0003995)1.96278500
128Facial cleft (HP:0002006)1.94692869
129Ankle contracture (HP:0006466)1.94624123
130Neonatal death (HP:0003811)1.94122341
131Vitreoretinal degeneration (HP:0000655)1.94097775
132Abnormality of dentin (HP:0010299)1.93649516
133Metaphyseal irregularity (HP:0003025)1.93596140
134Short middle phalanx of finger (HP:0005819)1.93453532
135Overlapping toe (HP:0001845)1.93296787
136Anophthalmia (HP:0000528)1.92701240
137Choanal stenosis (HP:0000452)1.92096843
138Lymphangioma (HP:0100764)1.91673965
139Bicornuate uterus (HP:0000813)1.89788226
140Poikilocytosis (HP:0004447)1.89385874
141Proximal tubulopathy (HP:0000114)1.88761908
142Rhabdomyosarcoma (HP:0002859)1.88649654
143Broad metatarsal (HP:0001783)1.87986000
144Premature rupture of membranes (HP:0001788)1.87799382
145Hypoplastic left heart (HP:0004383)1.86970035
146Soft skin (HP:0000977)1.86314971
147Anal stenosis (HP:0002025)1.86265316
148Myocardial infarction (HP:0001658)1.85071451
149Bifid scrotum (HP:0000048)1.84211598
150Mitral valve prolapse (HP:0001634)1.83825451
151Nephritis (HP:0000123)1.82230967
152Rectovaginal fistula (HP:0000143)1.81764570
153Rectal fistula (HP:0100590)1.81764570
154* Broad phalanges of the hand (HP:0009768)1.81509893
155Ectopic anus (HP:0004397)1.81014349
156Hypoplastic labia majora (HP:0000059)1.80545654
157Hypoglycemic seizures (HP:0002173)1.79641809
158Coronal craniosynostosis (HP:0004440)1.79426091
159Bronchomalacia (HP:0002780)1.78378263
160Sprengel anomaly (HP:0000912)1.78041600
161Bladder diverticulum (HP:0000015)1.77990368
162Fused cervical vertebrae (HP:0002949)1.77586749
163Morphological abnormality of the middle ear (HP:0008609)1.77162031
164Hyperglycinuria (HP:0003108)1.77106069
165* Broad finger (HP:0001500)1.76943828
166Abnormality of the incisor (HP:0000676)1.76491577
167Metaphyseal dysplasia (HP:0100255)1.76241441
168Deviation of the hallux (HP:0010051)1.75988424
169Pigmentary retinal degeneration (HP:0001146)1.74645347
170Missing ribs (HP:0000921)1.73542648
171Renal hypoplasia (HP:0000089)1.73368317
172Conjugated hyperbilirubinemia (HP:0002908)1.72993857
173Myelomeningocele (HP:0002475)1.71793723
174Absent eyebrow (HP:0002223)1.71728452
175Ulnar bowing (HP:0003031)1.71462488
176Rickets (HP:0002748)1.70575157
177* Broad long bones (HP:0005622)1.70037178
178Abnormality of serine family amino acid metabolism (HP:0010894)1.69694621
179Abnormality of glycine metabolism (HP:0010895)1.69694621
180Carpal synostosis (HP:0009702)1.68809210
181* Broad phalanx (HP:0006009)1.68628674
182Nasolacrimal duct obstruction (HP:0000579)1.67938230
183Trigonocephaly (HP:0000243)1.67569238
184Abnormality of the phalanges of the 2nd finger (HP:0009541)1.67345361
185Abnormality of the vitreous humor (HP:0004327)1.66910430
186Coxa vara (HP:0002812)1.65931103
187Neonatal short-limb short stature (HP:0008921)1.65618915
188Abnormality of the aortic arch (HP:0012303)1.65025051
189Intestinal fistula (HP:0100819)1.63800678
190Mildly elevated creatine phosphokinase (HP:0008180)1.63793669

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR46.82039222
2CDK125.56546919
3FGFR34.66346197
4WNK43.34641180
5ICK3.31260143
6LATS12.83131391
7TTK2.63186703
8CDC72.40449979
9LATS22.40424711
10STK38L2.36224779
11AKT32.23219005
12EPHA42.22724737
13MKNK12.19213316
14MAP3K102.14148518
15PIK3CA2.11643055
16PDGFRA2.05385522
17BUB11.93187746
18PAK41.87889427
19SRPK11.86562137
20TGFBR21.84884772
21CDK71.84479758
22EPHB21.75656800
23TGFBR11.69302771
24PASK1.68726727
25DDR21.60912977
26GRK51.60853524
27EEF2K1.60551456
28ERN11.59506724
29WEE11.54253568
30STK101.53579899
31PLK11.51988377
32STK31.49714758
33DYRK1B1.46388549
34WNK11.42160028
35MKNK21.41045928
36CHEK21.39962700
37PKN21.39841233
38PLK31.35808732
39NEK21.28987196
40FGFR11.16457899
41FGR1.14251599
42RET1.13826523
43OBSCN1.13375642
44MAPK71.12524487
45TRIB31.10839158
46CHEK11.10093742
47NEK11.07225619
48GRK61.07158646
49ERBB31.05146804
50AURKB1.03054395
51PRKAA21.02766346
52SGK2230.99225248
53SGK4940.99225248
54TYRO30.97422890
55BRSK20.97224139
56TAOK20.94594266
57RPS6KB20.91586040
58STK240.91068285
59MAPK110.89921786
60NUAK10.89628498
61MAP3K80.87537751
62CSNK1E0.86722105
63CSF1R0.86514488
64GRK10.86186011
65MTOR0.86094917
66CAMK40.86011087
67EPHA30.85793571
68PRKD30.81966046
69CLK10.80717685
70FLT30.80583057
71CDK80.80066155
72PAK20.80052131
73ERBB20.78642545
74CDK40.77929716
75PTK60.77316795
76MELK0.77282422
77NEK90.76850591
78SIK20.76318633
79PDK20.75590028
80ATR0.74884800
81BRD40.74002544
82PDPK10.73849995
83STK40.72945052
84AKT20.72202214
85NTRK20.72107581
86MET0.71967593
87PLK40.71930284
88SMG10.71697674
89ATM0.71468389
90ILK0.71160092
91ZAK0.70801801
92CDK20.70661699
93PTK20.69686192
94DYRK30.69326027
95TTN0.68107748
96RPS6KB10.68063261
97RPS6KA40.67605389
98STK390.67485067
99CAMK1D0.66348551
100MATK0.66058357
101ADRBK10.63873708
102PBK0.63573063
103CDK10.61885669
104SGK30.60344476
105EPHA20.59988875
106MAP3K20.59455446
107MYLK0.59387382
108ADRBK20.58823808
109LIMK10.57761426
110ACVR1B0.57670440
111EIF2AK20.56255142
112SGK10.55567607
113PRKCI0.54692452
114PRKAA10.54001174
115CAMK1G0.52734773
116RIPK10.52261934
117TSSK60.52044085
118AURKA0.51319987
119BCR0.50967798
120SGK20.50576841
121BRSK10.49900993
122CDC42BPA0.48880778
123CSNK1D0.47994459
124WNK30.47896514
125TESK10.46530662
126NTRK10.45704408
127PDK10.45640488
128CSNK2A20.43038661
129PRKG20.43006238
130PAK10.42777594
131FGFR20.42496619
132CDK60.42362149
133NLK0.42345925
134KSR10.42173213
135EIF2AK10.41920606
136AKT10.41023337
137CSNK2A10.40850944
138YES10.40019965
139CDK150.39853880
140NTRK30.39821871
141PLK20.39316124
142MAP3K70.39154212
143CDK180.36652797
144PRKCG0.36191180
145CDK11A0.35647353
146PRKACG0.35364290
147SRC0.34649831
148CDK90.34128306
149PDGFRB0.30536132
150PRKACB0.29194733
151PRKDC0.26566060
152ALK0.24675901

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046105.16181707
2Basal cell carcinoma_Homo sapiens_hsa052173.59081058
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.43295594
4Cell cycle_Homo sapiens_hsa041103.26392656
5DNA replication_Homo sapiens_hsa030303.09349369
6Hedgehog signaling pathway_Homo sapiens_hsa043403.06291478
7Fat digestion and absorption_Homo sapiens_hsa049753.02915382
8Mismatch repair_Homo sapiens_hsa034302.93458555
9Steroid biosynthesis_Homo sapiens_hsa001002.82435338
10Hippo signaling pathway_Homo sapiens_hsa043902.72653842
11Spliceosome_Homo sapiens_hsa030402.71832356
12RNA transport_Homo sapiens_hsa030132.60329564
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.57360661
14Vitamin digestion and absorption_Homo sapiens_hsa049772.53184959
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.48746232
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.47351216
17Arginine biosynthesis_Homo sapiens_hsa002202.46330085
18mRNA surveillance pathway_Homo sapiens_hsa030152.15958863
19Fatty acid degradation_Homo sapiens_hsa000712.14752053
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.12121119
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.10569826
22Base excision repair_Homo sapiens_hsa034102.06814237
23Fatty acid metabolism_Homo sapiens_hsa012122.05445162
24TGF-beta signaling pathway_Homo sapiens_hsa043502.03690028
25Pentose and glucuronate interconversions_Homo sapiens_hsa000402.02720591
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.99075104
27Fatty acid biosynthesis_Homo sapiens_hsa000611.98248484
28PPAR signaling pathway_Homo sapiens_hsa033201.97997871
29Adherens junction_Homo sapiens_hsa045201.87320254
30Thyroid cancer_Homo sapiens_hsa052161.85298316
31MicroRNAs in cancer_Homo sapiens_hsa052061.77540047
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74252243
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.73790941
34Homologous recombination_Homo sapiens_hsa034401.73132648
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.73089726
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.70838800
37Nucleotide excision repair_Homo sapiens_hsa034201.70159087
38RNA degradation_Homo sapiens_hsa030181.68944459
39Histidine metabolism_Homo sapiens_hsa003401.68345768
40One carbon pool by folate_Homo sapiens_hsa006701.67419335
41ECM-receptor interaction_Homo sapiens_hsa045121.63723354
42Protein digestion and absorption_Homo sapiens_hsa049741.63112861
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.61366411
44Wnt signaling pathway_Homo sapiens_hsa043101.58719074
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.57908740
46Phenylalanine metabolism_Homo sapiens_hsa003601.55928501
47Other glycan degradation_Homo sapiens_hsa005111.54694639
48Propanoate metabolism_Homo sapiens_hsa006401.51146639
49Starch and sucrose metabolism_Homo sapiens_hsa005001.50695656
50Arginine and proline metabolism_Homo sapiens_hsa003301.50553500
51Fanconi anemia pathway_Homo sapiens_hsa034601.45392964
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43320001
53Glycosaminoglycan degradation_Homo sapiens_hsa005311.42982701
54* Proteoglycans in cancer_Homo sapiens_hsa052051.41646982
55Focal adhesion_Homo sapiens_hsa045101.40041078
56Tight junction_Homo sapiens_hsa045301.36334224
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34903082
58Ribosome_Homo sapiens_hsa030101.34869788
59Pathways in cancer_Homo sapiens_hsa052001.33551232
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29615687
61HTLV-I infection_Homo sapiens_hsa051661.29057573
62Small cell lung cancer_Homo sapiens_hsa052221.28700139
63Oocyte meiosis_Homo sapiens_hsa041141.26031423
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25983002
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.25333977
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23316662
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22985751
68Tyrosine metabolism_Homo sapiens_hsa003501.22898097
69Steroid hormone biosynthesis_Homo sapiens_hsa001401.21979386
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21534330
71Transcriptional misregulation in cancer_Homo sapiens_hsa052021.20883753
72Notch signaling pathway_Homo sapiens_hsa043301.18827957
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.17149888
74Bile secretion_Homo sapiens_hsa049761.15475439
75p53 signaling pathway_Homo sapiens_hsa041151.14181233
76Pyruvate metabolism_Homo sapiens_hsa006201.13736253
77Fatty acid elongation_Homo sapiens_hsa000621.13663797
78Galactose metabolism_Homo sapiens_hsa000521.13127234
79Dilated cardiomyopathy_Homo sapiens_hsa054141.12101706
80Retinol metabolism_Homo sapiens_hsa008301.10147151
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09986327
82Cyanoamino acid metabolism_Homo sapiens_hsa004601.09720379
83Staphylococcus aureus infection_Homo sapiens_hsa051501.09478869
84Butanoate metabolism_Homo sapiens_hsa006501.07160235
85Basal transcription factors_Homo sapiens_hsa030221.05679342
86Fructose and mannose metabolism_Homo sapiens_hsa000511.04925898
87Peroxisome_Homo sapiens_hsa041461.03686287
88Colorectal cancer_Homo sapiens_hsa052101.02775143
89Prostate cancer_Homo sapiens_hsa052151.02232707
90Central carbon metabolism in cancer_Homo sapiens_hsa052301.00462656
91Chemical carcinogenesis_Homo sapiens_hsa052040.99424496
92ABC transporters_Homo sapiens_hsa020100.99386820
93Bladder cancer_Homo sapiens_hsa052190.98605743
94Nitrogen metabolism_Homo sapiens_hsa009100.97825011
95Melanogenesis_Homo sapiens_hsa049160.96156357
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95303534
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.94497062
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90973272
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90007796
100Thyroid hormone synthesis_Homo sapiens_hsa049180.88272473
101RNA polymerase_Homo sapiens_hsa030200.86447010
102Melanoma_Homo sapiens_hsa052180.86159097
103Arachidonic acid metabolism_Homo sapiens_hsa005900.84602622
104Axon guidance_Homo sapiens_hsa043600.84398224
105mTOR signaling pathway_Homo sapiens_hsa041500.83329353
106Endometrial cancer_Homo sapiens_hsa052130.81562689
107Lysine degradation_Homo sapiens_hsa003100.81155342
108Drug metabolism - other enzymes_Homo sapiens_hsa009830.80958361
109Viral carcinogenesis_Homo sapiens_hsa052030.80615024
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78772560
111Pyrimidine metabolism_Homo sapiens_hsa002400.78374833
112Rap1 signaling pathway_Homo sapiens_hsa040150.78275388
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75089933
114Systemic lupus erythematosus_Homo sapiens_hsa053220.72423800
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70842741
116Viral myocarditis_Homo sapiens_hsa054160.69860515
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69823101
118Chronic myeloid leukemia_Homo sapiens_hsa052200.67806756
119Glycerolipid metabolism_Homo sapiens_hsa005610.63300117
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61302502
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.59598248
122Herpes simplex infection_Homo sapiens_hsa051680.58749803
123Glucagon signaling pathway_Homo sapiens_hsa049220.57740490
124Non-small cell lung cancer_Homo sapiens_hsa052230.56751058
125Proteasome_Homo sapiens_hsa030500.56288743
126Renin-angiotensin system_Homo sapiens_hsa046140.54279429
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.54021231
128Ovarian steroidogenesis_Homo sapiens_hsa049130.53438000
129Tryptophan metabolism_Homo sapiens_hsa003800.53328249
130Prion diseases_Homo sapiens_hsa050200.53241666
131Non-homologous end-joining_Homo sapiens_hsa034500.51470834
132Biosynthesis of amino acids_Homo sapiens_hsa012300.51214456
133beta-Alanine metabolism_Homo sapiens_hsa004100.50555364
134Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50323469
135Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50189839
136Vitamin B6 metabolism_Homo sapiens_hsa007500.49243432
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46487885
138HIF-1 signaling pathway_Homo sapiens_hsa040660.45128547
139Mineral absorption_Homo sapiens_hsa049780.44503751
140Pancreatic cancer_Homo sapiens_hsa052120.44126568
141Carbon metabolism_Homo sapiens_hsa012000.42678008
142Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42657890
143Metabolic pathways_Homo sapiens_hsa011000.42342176
144AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40731931
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40029060
146Selenocompound metabolism_Homo sapiens_hsa004500.39809945
147Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39383568
148Epstein-Barr virus infection_Homo sapiens_hsa051690.37342987
149Alcoholism_Homo sapiens_hsa050340.36074456
150Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35747673
151Pentose phosphate pathway_Homo sapiens_hsa000300.35316572
152Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33071817
153Adipocytokine signaling pathway_Homo sapiens_hsa049200.31663053
154Sphingolipid metabolism_Homo sapiens_hsa006000.30211263
155Insulin resistance_Homo sapiens_hsa049310.30037509
156N-Glycan biosynthesis_Homo sapiens_hsa005100.29281519
157AMPK signaling pathway_Homo sapiens_hsa041520.28336444
158Purine metabolism_Homo sapiens_hsa002300.26058628
159Neurotrophin signaling pathway_Homo sapiens_hsa047220.25991167
160Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25211392
161Amoebiasis_Homo sapiens_hsa051460.24812830
162Cardiac muscle contraction_Homo sapiens_hsa042600.23858419
163Glioma_Homo sapiens_hsa052140.23847543
164Pertussis_Homo sapiens_hsa051330.19801185
165Glutathione metabolism_Homo sapiens_hsa004800.19301880
166Glycerophospholipid metabolism_Homo sapiens_hsa005640.18667582
167Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.17301757
168Protein export_Homo sapiens_hsa030600.17141111
169Insulin signaling pathway_Homo sapiens_hsa049100.15718271

Most similar genes based on co-expression Upload to Enrichr

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