GPATCH11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.95036121
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.84815623
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.67884615
4ATP synthesis coupled proton transport (GO:0015986)5.67884615
5central nervous system myelination (GO:0022010)5.58129785
6axon ensheathment in central nervous system (GO:0032291)5.58129785
7long-chain fatty acid biosynthetic process (GO:0042759)4.84757251
8neuron cell-cell adhesion (GO:0007158)4.83530159
9respiratory electron transport chain (GO:0022904)4.72062605
10protein neddylation (GO:0045116)4.68895826
11DNA deamination (GO:0045006)4.63368667
12electron transport chain (GO:0022900)4.60163353
13chaperone-mediated protein transport (GO:0072321)4.37181401
14maturation of 5.8S rRNA (GO:0000460)4.17224438
15fatty acid elongation (GO:0030497)4.11371084
16regulation of DNA endoreduplication (GO:0032875)4.02905954
17dopamine biosynthetic process (GO:0042416)4.02803879
18negative regulation of neurotransmitter transport (GO:0051589)3.99919396
19presynaptic membrane assembly (GO:0097105)3.91283327
20protein K6-linked ubiquitination (GO:0085020)3.80598202
21centriole replication (GO:0007099)3.79170324
22presynaptic membrane organization (GO:0097090)3.77974982
23vocalization behavior (GO:0071625)3.75193697
24regulation of dopamine metabolic process (GO:0042053)3.62179517
25regulation of catecholamine metabolic process (GO:0042069)3.62179517
26replication fork processing (GO:0031297)3.60082454
27proteasome assembly (GO:0043248)3.56311401
28protein deneddylation (GO:0000338)3.51743678
29substantia nigra development (GO:0021762)3.48431669
30transmission of nerve impulse (GO:0019226)3.43348944
31mitochondrial respiratory chain complex I assembly (GO:0032981)3.42638760
32NADH dehydrogenase complex assembly (GO:0010257)3.42638760
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.42638760
34establishment of protein localization to mitochondrial membrane (GO:0090151)3.40242284
35neuron recognition (GO:0008038)3.38238436
36DNA double-strand break processing (GO:0000729)3.36083212
37protein localization to synapse (GO:0035418)3.35708388
38dopamine transport (GO:0015872)3.34552663
39protein complex biogenesis (GO:0070271)3.33597500
40respiratory chain complex IV assembly (GO:0008535)3.32663852
41double-strand break repair via homologous recombination (GO:0000724)3.32635562
42positive regulation of synapse assembly (GO:0051965)3.31814524
43recombinational repair (GO:0000725)3.29650946
44water-soluble vitamin biosynthetic process (GO:0042364)3.25207958
45regulation of glutamate secretion (GO:0014048)3.23726806
46behavioral response to cocaine (GO:0048148)3.21449441
47response to pheromone (GO:0019236)3.21226463
48synaptic vesicle exocytosis (GO:0016079)3.18414411
49gamma-aminobutyric acid signaling pathway (GO:0007214)3.15717875
50neuronal action potential propagation (GO:0019227)3.14479544
51nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.14465003
52exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.14272229
53hydrogen ion transmembrane transport (GO:1902600)3.14227131
54cullin deneddylation (GO:0010388)3.11730618
55regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.09634714
56DNA catabolic process, exonucleolytic (GO:0000738)3.08661456
57negative regulation of synaptic transmission, GABAergic (GO:0032229)3.07838994
58RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.06540600
59rRNA catabolic process (GO:0016075)3.06130959
60neurotransmitter uptake (GO:0001504)3.05857793
61cholesterol biosynthetic process (GO:0006695)3.05850072
62somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.03131664
63isotype switching (GO:0045190)3.03131664
64somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.03131664
65ribonucleoprotein complex disassembly (GO:0032988)3.02371865
66meiotic chromosome segregation (GO:0045132)3.01732715
67synaptic transmission, dopaminergic (GO:0001963)3.01232000
68isoprenoid biosynthetic process (GO:0008299)2.99658771
69dendritic spine morphogenesis (GO:0060997)2.96282243
70ionotropic glutamate receptor signaling pathway (GO:0035235)2.94553141
71negative regulation of neurotransmitter secretion (GO:0046929)2.94220364
72glutamate receptor signaling pathway (GO:0007215)2.94046438
73positive regulation of mitotic sister chromatid separation (GO:1901970)2.91976118
74positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.91976118
75positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.91976118
76neuron-neuron synaptic transmission (GO:0007270)2.91888203
77negative regulation of DNA-dependent DNA replication (GO:2000104)2.91427842
78myelination (GO:0042552)2.91046679
79behavioral response to nicotine (GO:0035095)2.90416009
80cytochrome complex assembly (GO:0017004)2.89866416
81proton transport (GO:0015992)2.88940571
82positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.88377053
83regulation of centriole replication (GO:0046599)2.86356397
84somatic diversification of immune receptors via somatic mutation (GO:0002566)2.85968399
85somatic hypermutation of immunoglobulin genes (GO:0016446)2.85968399
86histone mRNA metabolic process (GO:0008334)2.85692914
87axon ensheathment (GO:0008366)2.83277565
88ensheathment of neurons (GO:0007272)2.83277565
89hydrogen transport (GO:0006818)2.82587866
90signal peptide processing (GO:0006465)2.82332628
91mitochondrial respiratory chain complex assembly (GO:0033108)2.80850911
92limb bud formation (GO:0060174)2.80806706
93ATP hydrolysis coupled proton transport (GO:0015991)2.80791281
94energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.80791281
95catecholamine biosynthetic process (GO:0042423)2.79144486
96catechol-containing compound biosynthetic process (GO:0009713)2.79144486
97negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.78461881
98phenol-containing compound catabolic process (GO:0019336)2.77427913
99ATP biosynthetic process (GO:0006754)2.76214396
100sterol biosynthetic process (GO:0016126)2.76120814
101kinetochore organization (GO:0051383)2.75839342
102reciprocal DNA recombination (GO:0035825)2.75746805
103reciprocal meiotic recombination (GO:0007131)2.75746805
104neuron remodeling (GO:0016322)2.75567373
105postreplication repair (GO:0006301)2.74742214
106negative regulation of protein localization to cell surface (GO:2000009)2.74298073
107response to histamine (GO:0034776)2.73606940
108protein K11-linked ubiquitination (GO:0070979)2.73518076
109CENP-A containing nucleosome assembly (GO:0034080)2.73005237
110purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.71481525
111righting reflex (GO:0060013)2.71329546
112organelle disassembly (GO:1903008)2.70979353
113tRNA processing (GO:0008033)2.69904152
114somatic recombination of immunoglobulin gene segments (GO:0016447)2.69160790
115ribosomal large subunit biogenesis (GO:0042273)2.68936002
116regulation of collateral sprouting (GO:0048670)2.68395773
117maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.67807431
118centriole assembly (GO:0098534)2.67063012
119somatic diversification of immunoglobulins (GO:0016445)2.65646500
120monoubiquitinated protein deubiquitination (GO:0035520)2.65379747
121purine nucleoside triphosphate biosynthetic process (GO:0009145)2.64877191
122chromatin remodeling at centromere (GO:0031055)2.63640645
123negative regulation of microtubule polymerization (GO:0031115)2.63214294
124membrane hyperpolarization (GO:0060081)2.62716709
125platelet dense granule organization (GO:0060155)2.62407242
126microtubule polymerization or depolymerization (GO:0031109)2.61739214
127response to epinephrine (GO:0071871)2.61669467
128neural tube formation (GO:0001841)2.61522001
129synaptic transmission, glutamatergic (GO:0035249)2.60430679
130positive regulation of cellular response to oxidative stress (GO:1900409)2.60344181
131positive regulation of response to oxidative stress (GO:1902884)2.60344181
132neural nucleus development (GO:0048857)2.60265649
133neurotransmitter catabolic process (GO:0042135)2.59842296
134intra-S DNA damage checkpoint (GO:0031573)2.59796757
135regulation of vesicle fusion (GO:0031338)2.57979563
136positive regulation of histone H3-K4 methylation (GO:0051571)2.57899289
137protoporphyrinogen IX biosynthetic process (GO:0006782)2.57423261
138axonal fasciculation (GO:0007413)2.56982453
139transferrin transport (GO:0033572)2.56230372
140dendrite development (GO:0016358)2.55664548
141serotonin receptor signaling pathway (GO:0007210)2.55359835
142cellular response to epinephrine stimulus (GO:0071872)2.54974729
143GTP biosynthetic process (GO:0006183)2.54916475
144calcium-mediated signaling using intracellular calcium source (GO:0035584)2.54774699
145anterograde synaptic vesicle transport (GO:0048490)2.54308598
146regulation of feeding behavior (GO:0060259)2.54290745
147nucleotide-excision repair, DNA gap filling (GO:0006297)2.54137766
148transcription elongation from RNA polymerase III promoter (GO:0006385)2.53785822
149termination of RNA polymerase III transcription (GO:0006386)2.53785822
150regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.53741274
151rRNA processing (GO:0006364)2.51984084
152positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.51046748
153establishment of mitochondrion localization (GO:0051654)2.50676365
154regulation of protein kinase A signaling (GO:0010738)2.50368852
155rRNA metabolic process (GO:0016072)2.50066377
156response to cocaine (GO:0042220)2.49922690
157regulation of short-term neuronal synaptic plasticity (GO:0048172)2.49868229
158regulation of synapse assembly (GO:0051963)2.49864851
159intracellular protein transmembrane import (GO:0044743)2.49571184
160detection of calcium ion (GO:0005513)2.49333596
161positive regulation of action potential (GO:0045760)2.49192485
162ribosome assembly (GO:0042255)2.47485247
163regulation of excitatory postsynaptic membrane potential (GO:0060079)2.47484705
164DNA replication checkpoint (GO:0000076)2.47102284
165negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.47099505
166synapsis (GO:0007129)2.46942331
167double-strand break repair (GO:0006302)2.46585306
168mismatch repair (GO:0006298)2.45153649
169spliceosomal complex assembly (GO:0000245)2.43397261
170peptidyl-histidine modification (GO:0018202)2.40640934
171microtubule depolymerization (GO:0007019)2.38507213
172piRNA metabolic process (GO:0034587)2.38093297
173histone mRNA catabolic process (GO:0071044)2.37969301
174regulation of centrosome cycle (GO:0046605)2.36993282
175DNA ligation (GO:0006266)2.36185568
176DNA recombination (GO:0006310)2.35490691
177protein prenylation (GO:0018342)2.34430164
178prenylation (GO:0097354)2.34430164
179kinetochore assembly (GO:0051382)2.34283575
180telomere maintenance via recombination (GO:0000722)2.33976359
181folic acid-containing compound biosynthetic process (GO:0009396)2.33764619
182resolution of meiotic recombination intermediates (GO:0000712)2.33459723
183anterograde axon cargo transport (GO:0008089)2.32872871
184inositol phosphate catabolic process (GO:0071545)2.31696940
185protein localization to mitochondrion (GO:0070585)2.30974810
186double-strand break repair via nonhomologous end joining (GO:0006303)2.30376553
187non-recombinational repair (GO:0000726)2.30376553
188negative regulation of DNA recombination (GO:0045910)2.29851465

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.72708766
2GBX2_23144817_ChIP-Seq_PC3_Human3.68402526
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.28360837
4E2F7_22180533_ChIP-Seq_HELA_Human3.16449196
5TAF15_26573619_Chip-Seq_HEK293_Human3.11479996
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.95203803
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.75191152
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.74273264
9ELK1_19687146_ChIP-ChIP_HELA_Human2.69512523
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.65233740
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.62492162
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.59707173
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.57009703
14VDR_22108803_ChIP-Seq_LS180_Human2.56013182
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.54268056
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52214996
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.36214081
18VDR_23849224_ChIP-Seq_CD4+_Human2.35136524
19BMI1_23680149_ChIP-Seq_NPCS_Mouse2.27276719
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24690568
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.22124028
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.20733994
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.20592388
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.17940812
25ETS1_20019798_ChIP-Seq_JURKAT_Human2.16449650
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.13943686
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13668086
28POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12905889
29CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10812833
30JARID2_20075857_ChIP-Seq_MESCs_Mouse2.10276524
31CREB1_15753290_ChIP-ChIP_HEK293T_Human2.05990798
32CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02345447
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.01832156
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00952241
35FUS_26573619_Chip-Seq_HEK293_Human2.00937462
36P300_19829295_ChIP-Seq_ESCs_Human1.95210160
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94166352
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.93481726
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.93392451
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.93392451
41ER_23166858_ChIP-Seq_MCF-7_Human1.89835545
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.87912075
43MTF2_20144788_ChIP-Seq_MESCs_Mouse1.87485776
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.84762137
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.84594452
46FOXP3_21729870_ChIP-Seq_TREG_Human1.80775133
47SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.80239250
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77258038
49REST_21632747_ChIP-Seq_MESCs_Mouse1.75933144
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.75697202
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74900470
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73221726
53IGF1R_20145208_ChIP-Seq_DFB_Human1.71466553
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.69936033
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.67824016
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66719517
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66128480
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.63362714
59MYC_18940864_ChIP-ChIP_HL60_Human1.60567814
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.59109970
61SMAD4_21799915_ChIP-Seq_A2780_Human1.55789665
62CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.54885718
63RNF2_27304074_Chip-Seq_ESCs_Mouse1.54333383
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.53472761
65AR_21572438_ChIP-Seq_LNCaP_Human1.53238194
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51978583
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51851890
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49980464
69RNF2_27304074_Chip-Seq_NSC_Mouse1.47756419
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46271347
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41899255
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.40431955
73EWS_26573619_Chip-Seq_HEK293_Human1.38544069
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.34082439
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33229326
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.32713208
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32307346
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32159709
79FLI1_27457419_Chip-Seq_LIVER_Mouse1.31680728
80IRF1_19129219_ChIP-ChIP_H3396_Human1.30160897
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.29238220
82REST_18959480_ChIP-ChIP_MESCs_Mouse1.29154535
83GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28573104
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28141538
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26792309
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26340000
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26258647
88CBP_20019798_ChIP-Seq_JUKART_Human1.25968073
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25968073
90EZH2_27294783_Chip-Seq_NPCs_Mouse1.25426068
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24852891
92TP53_22573176_ChIP-Seq_HFKS_Human1.23316822
93HTT_18923047_ChIP-ChIP_STHdh_Human1.23250685
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.21831228
95DCP1A_22483619_ChIP-Seq_HELA_Human1.21788621
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21713262
97IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20670857
98JUN_21703547_ChIP-Seq_K562_Human1.20639497
99EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20035972
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17841425
101HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17568081
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.17362348
103CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.16030788
104GABP_19822575_ChIP-Seq_HepG2_Human1.15461666
105RUNX2_22187159_ChIP-Seq_PCA_Human1.15377295
106AR_25329375_ChIP-Seq_VCAP_Human1.14834735
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13840008
108RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13142006
109NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12940344
110CMYC_18555785_Chip-Seq_ESCs_Mouse1.12843864
111TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12335020
112PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11957589
113SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11527869
114E2F1_18555785_Chip-Seq_ESCs_Mouse1.09641316
115KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.09242723
116ZNF274_21170338_ChIP-Seq_K562_Hela1.09116953
117FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.08799142
118TP53_18474530_ChIP-ChIP_U2OS_Human1.08680203
119P53_22387025_ChIP-Seq_ESCs_Mouse1.08066966
120DROSHA_22980978_ChIP-Seq_HELA_Human1.07500026
121TCF4_23295773_ChIP-Seq_U87_Human1.06495292
122POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05794075
123SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05224277
124TAL1_26923725_Chip-Seq_HPCs_Mouse1.04860766
125FLI1_21867929_ChIP-Seq_TH2_Mouse1.04435327
126TTF2_22483619_ChIP-Seq_HELA_Human1.04286403
127HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04122517
128EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04105960
129TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03003591
130STAT3_18555785_Chip-Seq_ESCs_Mouse1.02523369
131MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02084020
132P300_18555785_Chip-Seq_ESCs_Mouse1.01754376
133TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01729585
134SOX2_18555785_Chip-Seq_ESCs_Mouse1.00263392
135CRX_20693478_ChIP-Seq_RETINA_Mouse1.00122183
136CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99957757
137BP1_19119308_ChIP-ChIP_Hs578T_Human0.99919984
138E2F1_21310950_ChIP-Seq_MCF-7_Human0.99430223
139GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98529691
140SOX2_19829295_ChIP-Seq_ESCs_Human0.98380536
141NANOG_19829295_ChIP-Seq_ESCs_Human0.98380536
142KDM2B_26808549_Chip-Seq_REH_Human0.97251893
143AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97162754
144STAT3_23295773_ChIP-Seq_U87_Human0.96912027
145PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96084787
146SMAD_19615063_ChIP-ChIP_OVARY_Human0.95720372
147KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92700508
148FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91652908
149MYC_18555785_ChIP-Seq_MESCs_Mouse0.91298828
150TCF4_22108803_ChIP-Seq_LS180_Human0.91178158

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.05767521
2MP0008057_abnormal_DNA_replication4.95664577
3MP0001529_abnormal_vocalization3.88664569
4MP0004270_analgesia3.64556541
5MP0008058_abnormal_DNA_repair3.33687176
6MP0001905_abnormal_dopamine_level3.10652078
7MP0000569_abnormal_digit_pigmentation3.01449126
8MP0004859_abnormal_synaptic_plasticity3.01273139
9MP0006276_abnormal_autonomic_nervous2.80019326
10MP0003635_abnormal_synaptic_transmissio2.78064821
11MP0009745_abnormal_behavioral_response2.76492075
12MP0010094_abnormal_chromosome_stability2.72103381
13MP0001968_abnormal_touch/_nociception2.71322703
14MP0005423_abnormal_somatic_nervous2.65316072
15MP0002064_seizures2.65308647
16MP0002736_abnormal_nociception_after2.61570465
17MP0002272_abnormal_nervous_system2.59540073
18MP0009046_muscle_twitch2.54942163
19MP0002735_abnormal_chemical_nociception2.52276813
20MP0002734_abnormal_mechanical_nocicepti2.40833852
21MP0002572_abnormal_emotion/affect_behav2.38081198
22MP0002063_abnormal_learning/memory/cond2.24061305
23MP0000920_abnormal_myelination2.22223225
24MP0008877_abnormal_DNA_methylation2.21559277
25MP0002822_catalepsy2.17533168
26MP0001486_abnormal_startle_reflex2.15922357
27MP0001440_abnormal_grooming_behavior2.08970971
28MP0000778_abnormal_nervous_system2.02506158
29MP0001188_hyperpigmentation1.98731524
30MP0005409_darkened_coat_color1.93932276
31MP0002009_preneoplasia1.91250909
32MP0004142_abnormal_muscle_tone1.90707951
33MP0001970_abnormal_pain_threshold1.89899069
34MP0001501_abnormal_sleep_pattern1.88758090
35MP0004924_abnormal_behavior1.85919601
36MP0005386_behavior/neurological_phenoty1.85919601
37MP0002067_abnormal_sensory_capabilities1.85113775
38MP0005171_absent_coat_pigmentation1.76509315
39MP0004742_abnormal_vestibular_system1.76028062
40MP0009697_abnormal_copulation1.74596469
41MP0009379_abnormal_foot_pigmentation1.72027397
42MP0008995_early_reproductive_senescence1.68831459
43MP0002733_abnormal_thermal_nociception1.65091111
44MP0005174_abnormal_tail_pigmentation1.62502586
45MP0002102_abnormal_ear_morphology1.62237281
46MP0002184_abnormal_innervation1.57270940
47MP0004147_increased_porphyrin_level1.55056742
48MP0002837_dystrophic_cardiac_calcinosis1.54947386
49MP0003077_abnormal_cell_cycle1.54084967
50MP0005551_abnormal_eye_electrophysiolog1.52817879
51MP0003329_amyloid_beta_deposits1.52058143
52MP0003786_premature_aging1.51506386
53MP0005645_abnormal_hypothalamus_physiol1.48538694
54MP0003693_abnormal_embryo_hatching1.46486583
55MP0000427_abnormal_hair_cycle1.40238151
56MP0001984_abnormal_olfaction1.40065884
57MP0003806_abnormal_nucleotide_metabolis1.40043983
58MP0002557_abnormal_social/conspecific_i1.38601142
59MP0008007_abnormal_cellular_replicative1.37188586
60MP0003111_abnormal_nucleus_morphology1.36523741
61MP0003121_genomic_imprinting1.34866211
62MP0005075_abnormal_melanosome_morpholog1.33846580
63MP0006072_abnormal_retinal_apoptosis1.32973428
64MP0005084_abnormal_gallbladder_morpholo1.32830500
65MP0003011_delayed_dark_adaptation1.32001676
66MP0002160_abnormal_reproductive_system1.31736903
67MP0003136_yellow_coat_color1.31246409
68MP0002095_abnormal_skin_pigmentation1.28571389
69MP0002882_abnormal_neuron_morphology1.28519016
70MP0003122_maternal_imprinting1.26296198
71MP0006036_abnormal_mitochondrial_physio1.25253287
72MP0002928_abnormal_bile_duct1.23685784
73MP0002066_abnormal_motor_capabilities/c1.23576054
74MP0002163_abnormal_gland_morphology1.22031205
75MP0001986_abnormal_taste_sensitivity1.21610340
76MP0005379_endocrine/exocrine_gland_phen1.21175856
77MP0008569_lethality_at_weaning1.20263717
78MP0002638_abnormal_pupillary_reflex1.19492638
79MP0002229_neurodegeneration1.16824784
80MP0005394_taste/olfaction_phenotype1.15138342
81MP0005499_abnormal_olfactory_system1.15138342
82MP0010386_abnormal_urinary_bladder1.14742307
83MP0002876_abnormal_thyroid_physiology1.12407828
84MP0000372_irregular_coat_pigmentation1.11877586
85MP0000955_abnormal_spinal_cord1.10944926
86MP0002234_abnormal_pharynx_morphology1.10654627
87MP0005187_abnormal_penis_morphology1.10372254
88MP0001963_abnormal_hearing_physiology1.09031727
89MP0002752_abnormal_somatic_nervous1.07467736
90MP0008789_abnormal_olfactory_epithelium1.07064634
91MP0002210_abnormal_sex_determination1.06974402
92MP0003634_abnormal_glial_cell1.05768176
93MP0000015_abnormal_ear_pigmentation1.02719159
94MP0003632_abnormal_nervous_system1.02492025
95MP0005646_abnormal_pituitary_gland1.02136890
96MP0005266_abnormal_metabolism0.99600212
97MP0002396_abnormal_hematopoietic_system0.98858466
98MP0005389_reproductive_system_phenotype0.95283184
99MP0005253_abnormal_eye_physiology0.95129992
100MP0003787_abnormal_imprinting0.94976653
101MP0001485_abnormal_pinna_reflex0.94741202
102MP0003631_nervous_system_phenotype0.94551781
103MP0006292_abnormal_olfactory_placode0.94110340
104MP0000026_abnormal_inner_ear0.93758964
105MP0003186_abnormal_redox_activity0.93758356
106MP0005451_abnormal_body_composition0.91781092
107MP0003718_maternal_effect0.91199862
108MP0004811_abnormal_neuron_physiology0.91076885
109MP0003690_abnormal_glial_cell0.90596668
110MP0001502_abnormal_circadian_rhythm0.89043548
111MP0006035_abnormal_mitochondrial_morpho0.88595247
112MP0001929_abnormal_gametogenesis0.88001375
113MP0008875_abnormal_xenobiotic_pharmacok0.87976020
114MP0008872_abnormal_physiological_respon0.87893701
115MP0003221_abnormal_cardiomyocyte_apopto0.87598107
116MP0002909_abnormal_adrenal_gland0.86991137
117MP0005083_abnormal_biliary_tract0.85276075
118MP0002152_abnormal_brain_morphology0.82750969
119MP0002751_abnormal_autonomic_nervous0.82584315
120MP0002006_tumorigenesis0.81144229
121MP0000631_abnormal_neuroendocrine_gland0.80911053
122MP0004957_abnormal_blastocyst_morpholog0.80694736
123MP0000653_abnormal_sex_gland0.80347018
124MP0004145_abnormal_muscle_electrophysio0.79625906
125MP0000647_abnormal_sebaceous_gland0.78412887
126MP0005195_abnormal_posterior_eye0.77100189
127MP0003633_abnormal_nervous_system0.76676006
128MP0001145_abnormal_male_reproductive0.74524538
129MP0008932_abnormal_embryonic_tissue0.73747535
130MP0003252_abnormal_bile_duct0.73151528
131MP0000751_myopathy0.72417472
132MP0005410_abnormal_fertilization0.70897917
133MP0000358_abnormal_cell_content/0.70530799
134MP0001919_abnormal_reproductive_system0.69421912
135MP0004885_abnormal_endolymph0.68608249
136MP0001727_abnormal_embryo_implantation0.68342449
137MP0004130_abnormal_muscle_cell0.67587546
138MP0004215_abnormal_myocardial_fiber0.67190624
139MP0001944_abnormal_pancreas_morphology0.66756150
140MP0001664_abnormal_digestion0.66179376
141MP0000013_abnormal_adipose_tissue0.64976303
142MP0002069_abnormal_eating/drinking_beha0.64665507
143MP0003938_abnormal_ear_development0.64236745
144MP0008874_decreased_physiological_sensi0.62211190
145MP0004085_abnormal_heartbeat0.61288582
146MP0003137_abnormal_impulse_conducting0.59344797
147MP0000566_synostosis0.58028639
148MP0000538_abnormal_urinary_bladder0.57628885
149MP0002938_white_spotting0.56098614
150MP0002090_abnormal_vision0.55237960
151MP0003950_abnormal_plasma_membrane0.54738277

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.52274487
2Progressive macrocephaly (HP:0004481)4.77903688
3Abnormal mitochondria in muscle tissue (HP:0008316)4.77405567
4Mitochondrial inheritance (HP:0001427)4.57448232
5Acute encephalopathy (HP:0006846)4.20248376
6Increased hepatocellular lipid droplets (HP:0006565)3.89994884
7Focal motor seizures (HP:0011153)3.87450717
8Renal Fanconi syndrome (HP:0001994)3.76838942
9Increased CSF lactate (HP:0002490)3.72436456
10Myokymia (HP:0002411)3.64906558
11Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.56198559
12Degeneration of the lateral corticospinal tracts (HP:0002314)3.51572897
13Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.51572897
14Limb dystonia (HP:0002451)3.50106181
15Parakeratosis (HP:0001036)3.41258684
16Molar tooth sign on MRI (HP:0002419)3.33257613
17Abnormality of midbrain morphology (HP:0002418)3.33257613
18Optic disc pallor (HP:0000543)3.31099157
19Epileptic encephalopathy (HP:0200134)3.30558999
20Lipid accumulation in hepatocytes (HP:0006561)3.23009347
21Birth length less than 3rd percentile (HP:0003561)3.20011462
22Hepatocellular necrosis (HP:0001404)3.18448296
23Leukodystrophy (HP:0002415)3.13557853
24Atonic seizures (HP:0010819)3.10480548
25Neurofibrillary tangles (HP:0002185)3.02342184
26Pancreatic cysts (HP:0001737)2.99619999
27Abnormality of glycolysis (HP:0004366)2.97756481
28Increased serum pyruvate (HP:0003542)2.97756481
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.96822476
303-Methylglutaconic aciduria (HP:0003535)2.94776836
31Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.90422838
32Abnormality of the corticospinal tract (HP:0002492)2.89319266
33True hermaphroditism (HP:0010459)2.85664129
34Gaze-evoked nystagmus (HP:0000640)2.82154658
35Partial agenesis of the corpus callosum (HP:0001338)2.79772507
36Hypothermia (HP:0002045)2.78424490
37Hyperventilation (HP:0002883)2.78113524
38Pancreatic fibrosis (HP:0100732)2.74469827
39Abnormality of the renal cortex (HP:0011035)2.74095280
40Renal cortical cysts (HP:0000803)2.73862278
41Broad-based gait (HP:0002136)2.71379949
42Focal seizures (HP:0007359)2.70384638
43Cerebral inclusion bodies (HP:0100314)2.64080529
44Sensory axonal neuropathy (HP:0003390)2.58716777
45Medial flaring of the eyebrow (HP:0010747)2.58237615
46Volvulus (HP:0002580)2.57927481
47Cerebral edema (HP:0002181)2.57610607
48Gait imbalance (HP:0002141)2.55195957
49Abnormality of chromosome stability (HP:0003220)2.52455403
50Nephronophthisis (HP:0000090)2.49995846
51X-linked dominant inheritance (HP:0001423)2.46779387
52Respiratory failure (HP:0002878)2.46355617
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.43773390
54Abnormality of alanine metabolism (HP:0010916)2.43773390
55Hyperalaninemia (HP:0003348)2.43773390
56Abnormal hair whorl (HP:0010721)2.43707462
57Abnormality of renal resorption (HP:0011038)2.43456452
58Febrile seizures (HP:0002373)2.43205397
59Neuroendocrine neoplasm (HP:0100634)2.43102189
60Pheochromocytoma (HP:0002666)2.42136543
61Progressive cerebellar ataxia (HP:0002073)2.40088656
62Exercise intolerance (HP:0003546)2.37559656
63Increased intramyocellular lipid droplets (HP:0012240)2.37221247
64Vaginal atresia (HP:0000148)2.33556653
65Genital tract atresia (HP:0001827)2.33326763
66Nephrogenic diabetes insipidus (HP:0009806)2.31076010
67Congenital ichthyosiform erythroderma (HP:0007431)2.28757371
68Hepatic necrosis (HP:0002605)2.28668050
69Abnormality of the labia minora (HP:0012880)2.27422511
70Aplasia/Hypoplasia of the uvula (HP:0010293)2.27281506
71Congenital primary aphakia (HP:0007707)2.26896819
72Dialeptic seizures (HP:0011146)2.25887832
73Abnormality of the renal medulla (HP:0100957)2.25086802
74Poor coordination (HP:0002370)2.22432817
75Chronic hepatic failure (HP:0100626)2.20923057
76Fetal akinesia sequence (HP:0001989)2.20256008
77Absence seizures (HP:0002121)2.17891359
78Abnormal ciliary motility (HP:0012262)2.16850226
79Exertional dyspnea (HP:0002875)2.16495564
80Abnormal delayed hypersensitivity skin test (HP:0002963)2.16429745
81Intestinal atresia (HP:0011100)2.16383471
82Chromsome breakage (HP:0040012)2.13679646
83Retinal dysplasia (HP:0007973)2.12153972
84Metaphyseal dysplasia (HP:0100255)2.10958708
85Abnormality of the ileum (HP:0001549)2.09510531
86Constricted visual fields (HP:0001133)2.09249967
87Abnormality of placental membranes (HP:0011409)2.09216048
88Amniotic constriction ring (HP:0009775)2.09216048
89Chromosomal breakage induced by crosslinking agents (HP:0003221)2.08998609
90Neoplasm of the adrenal cortex (HP:0100641)2.07367151
91Lactic acidosis (HP:0003128)2.06698014
92Meckel diverticulum (HP:0002245)2.05509047
93Abnormality of the septum pellucidum (HP:0007375)2.05184287
94Autoamputation (HP:0001218)2.04064904
95Progressive inability to walk (HP:0002505)2.04064370
96Cerebral hemorrhage (HP:0001342)2.02359189
97Drooling (HP:0002307)1.98008037
98Esotropia (HP:0000565)1.96965490
99Dynein arm defect of respiratory motile cilia (HP:0012255)1.96494604
100Absent/shortened dynein arms (HP:0200106)1.96494604
101Increased serum lactate (HP:0002151)1.95265950
102Attenuation of retinal blood vessels (HP:0007843)1.95009980
103Congenital stationary night blindness (HP:0007642)1.92270842
104Clubbing of toes (HP:0100760)1.90947975
105Oculomotor apraxia (HP:0000657)1.90538276
106Spastic gait (HP:0002064)1.89215190
107Muscle hypertrophy of the lower extremities (HP:0008968)1.89019446
108Abnormal pupillary function (HP:0007686)1.88375487
109Progressive microcephaly (HP:0000253)1.88193986
110Termporal pattern (HP:0011008)1.87771754
111Insidious onset (HP:0003587)1.87771754
112Dysmetria (HP:0001310)1.86964966
113Respiratory difficulties (HP:0002880)1.86804096
114Abnormality of T cell physiology (HP:0011840)1.85284152
115Diastasis recti (HP:0001540)1.83678373
116Myelodysplasia (HP:0002863)1.82852360
117Epileptiform EEG discharges (HP:0011182)1.81982892
118Medulloblastoma (HP:0002885)1.80968618
119Visual hallucinations (HP:0002367)1.79520063
120Neutropenia (HP:0001875)1.79313153
121Sloping forehead (HP:0000340)1.78789800
122B lymphocytopenia (HP:0010976)1.78785396
123Amblyopia (HP:0000646)1.78486564
124Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78395493
125EEG with generalized epileptiform discharges (HP:0011198)1.77338450
126Excessive salivation (HP:0003781)1.76850726
127Delusions (HP:0000746)1.75640266
128Small hand (HP:0200055)1.74652075
129Supranuclear gaze palsy (HP:0000605)1.74306795
130Peripheral hypomyelination (HP:0007182)1.73219298
131Aplasia/Hypoplasia of the lens (HP:0008063)1.73206389
132Abnormality of B cell number (HP:0010975)1.73000326
133Bony spicule pigmentary retinopathy (HP:0007737)1.72284355
134Aplasia/Hypoplasia of the tibia (HP:0005772)1.72024497
135Fair hair (HP:0002286)1.72020282
136Polyphagia (HP:0002591)1.71960106
137Generalized tonic-clonic seizures (HP:0002069)1.71624593
138Abnormality of the preputium (HP:0100587)1.71438506
139Poor suck (HP:0002033)1.70734310
140Akinesia (HP:0002304)1.70429317
141Hypsarrhythmia (HP:0002521)1.70388114
142Abnormal biliary tract physiology (HP:0012439)1.69481675
143Bile duct proliferation (HP:0001408)1.69481675
144Abnormality of the carotid arteries (HP:0005344)1.69253777
145Hepatoblastoma (HP:0002884)1.68676168
146Increased muscle lipid content (HP:0009058)1.68647679
147Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.68162762
148Decreased activity of mitochondrial respiratory chain (HP:0008972)1.68162762
149Methylmalonic acidemia (HP:0002912)1.67785054
150Cupped ear (HP:0000378)1.67610357
151Ankle clonus (HP:0011448)1.67461457
152Oligodactyly (hands) (HP:0001180)1.66825947
153Abnormal rod and cone electroretinograms (HP:0008323)1.65942984
154Inability to walk (HP:0002540)1.64641955
155Panhypogammaglobulinemia (HP:0003139)1.62477511
156Duodenal stenosis (HP:0100867)1.61309651
157Small intestinal stenosis (HP:0012848)1.61309651
158Methylmalonic aciduria (HP:0012120)1.61176501
159Hemiparesis (HP:0001269)1.59309590
160Sclerocornea (HP:0000647)1.58070546
161Abnormality of eosinophils (HP:0001879)1.56882832
162Abnormality of the anterior horn cell (HP:0006802)1.55962363
163Degeneration of anterior horn cells (HP:0002398)1.55962363

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.32790229
2MAP4K23.27234389
3CASK3.20374717
4STK393.14761455
5MARK12.84078297
6EIF2AK32.77550818
7STK162.71210509
8TLK12.69320795
9MAP2K72.63153585
10PNCK2.60896984
11OXSR12.44043147
12CAMKK22.37427874
13PBK2.35439923
14TNIK2.34640174
15TRIM282.30588923
16MAP3K122.30202637
17EPHA42.24620343
18MAP3K42.22306767
19EIF2AK12.20249209
20BCR1.98320661
21CAMK2B1.89111920
22PINK11.88976666
23GRK71.83483316
24TAOK31.81894666
25PLK21.81259668
26CDC71.80622759
27GRK51.80445382
28CCNB11.80374959
29NTRK31.78168879
30MAPK131.72892246
31TSSK61.66687661
32SRPK11.66083172
33NME11.64629540
34LIMK11.63699046
35BUB11.61037834
36ERBB31.58933713
37UHMK11.53022681
38NTRK21.52599558
39WEE11.52075757
40NEK21.46421814
41PLK41.42919221
42BMPR21.41232666
43WNK41.40654922
44CAMK2D1.39041090
45MAPKAPK51.37395196
46PKN11.36821374
47CSNK1G31.36264270
48FGR1.34264899
49CAMK2A1.32363589
50PLK31.31228440
51RIPK41.29130016
52DYRK21.27135974
53MINK11.25954782
54CDK191.22601997
55MST41.20058350
56NTRK11.17272716
57CAMK2G1.14625198
58NEK11.09782369
59BRSK21.09691955
60CSNK1G21.09258874
61ADRBK21.07402983
62ZAK1.06951326
63AKT31.05470329
64MYLK1.04177490
65TEC1.02211286
66ROCK20.97387139
67CAMK1D0.96801285
68CDK50.94371032
69PRKCE0.92711780
70ATR0.92409823
71BMPR1B0.91816641
72CSNK1A1L0.89335921
73MAP2K40.88774221
74ARAF0.88709163
75KIT0.88345563
76NEK60.88010207
77MUSK0.87412044
78CSNK1G10.87116147
79ATM0.81687261
80MKNK20.81528721
81PTK2B0.81105703
82EPHB10.79944524
83PLK10.78709924
84EIF2AK20.77419885
85WNK10.76985253
86FES0.76671670
87MKNK10.76077053
88INSRR0.74341263
89CAMK1G0.72575777
90OBSCN0.70956628
91ADRBK10.70941583
92DYRK1A0.68098570
93PRKCG0.67766963
94CDK140.67148974
95STK30.66296156
96SGK4940.64164375
97SGK2230.64164375
98PRKG10.63660058
99PRKG20.63017238
100CDK80.61485889
101GRK10.60734466
102YES10.59250072
103PRKACA0.57965502
104CDK180.57714982
105ERBB40.57425495
106SIK30.56597842
107ACVR1B0.55440362
108DAPK30.54729049
109CSNK1E0.54455577
110CDK150.54334038
111PHKG10.53038651
112PHKG20.53038651
113PRKCQ0.52494516
114SIK20.52274390
115BRAF0.52169783
116WNK30.51990750
117PIM10.51976680
118CSNK1D0.51000023
119IRAK20.49727238
120GRK60.48157453
121CDK30.48005662
122TGFBR10.47934514
123STK40.47800327
124CDK11A0.46641975
125SYK0.46021580
126TXK0.45963857
127CHEK20.45405894
128DYRK30.45309358
129CSNK2A20.43707790
130MARK30.42128136
131PIK3CG0.40690251
132SGK20.39967040
133PAK30.39636266
134CHEK10.39425326
135AURKB0.38650838
136VRK10.37977114
137TTK0.37429491
138PAK60.37393133
139PRKACB0.37115634
140PRKCA0.36567207
141MAP3K60.36075654
142ROCK10.35957175
143ABL10.35648273
144MAPK40.35378915
145STK100.35008332
146PRPF4B0.34122527
147CSNK2A10.33881056
148FYN0.33659540
149TNK20.33432919
150CDK40.33234757
151NUAK10.32492681
152TESK20.32231256
153PIK3CA0.32168443
154FGFR20.31982674
155CSNK1A10.31747829
156CDK10.31110945

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.86838816
2Parkinsons disease_Homo sapiens_hsa050123.97823041
3Alzheimers disease_Homo sapiens_hsa050103.48830512
4Homologous recombination_Homo sapiens_hsa034403.26608907
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.14708047
6Nicotine addiction_Homo sapiens_hsa050332.89742342
7Huntingtons disease_Homo sapiens_hsa050162.80106758
8Mismatch repair_Homo sapiens_hsa034302.72326598
9Fanconi anemia pathway_Homo sapiens_hsa034602.71010090
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.67088508
11Collecting duct acid secretion_Homo sapiens_hsa049662.53429230
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.45329473
13Serotonergic synapse_Homo sapiens_hsa047262.25576035
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.25170434
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.22562381
16Cardiac muscle contraction_Homo sapiens_hsa042602.18654134
17DNA replication_Homo sapiens_hsa030302.15057880
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.14354762
19Nucleotide excision repair_Homo sapiens_hsa034202.14217814
20RNA degradation_Homo sapiens_hsa030182.11881629
21Proteasome_Homo sapiens_hsa030501.97442633
22Protein export_Homo sapiens_hsa030601.94555889
23One carbon pool by folate_Homo sapiens_hsa006701.93970042
24Glutamatergic synapse_Homo sapiens_hsa047241.91322762
25Phototransduction_Homo sapiens_hsa047441.90639915
26GABAergic synapse_Homo sapiens_hsa047271.88771494
27Fatty acid elongation_Homo sapiens_hsa000621.86855224
28Synaptic vesicle cycle_Homo sapiens_hsa047211.83668001
29Propanoate metabolism_Homo sapiens_hsa006401.82224936
30Morphine addiction_Homo sapiens_hsa050321.71146721
31RNA transport_Homo sapiens_hsa030131.65013814
32Circadian entrainment_Homo sapiens_hsa047131.60812344
33Long-term depression_Homo sapiens_hsa047301.60580383
34Taste transduction_Homo sapiens_hsa047421.56733713
35Caffeine metabolism_Homo sapiens_hsa002321.56640345
36Steroid biosynthesis_Homo sapiens_hsa001001.56108709
37Dopaminergic synapse_Homo sapiens_hsa047281.53581679
38Vibrio cholerae infection_Homo sapiens_hsa051101.48361692
39Long-term potentiation_Homo sapiens_hsa047201.47853349
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47640060
41Spliceosome_Homo sapiens_hsa030401.45986955
42Amphetamine addiction_Homo sapiens_hsa050311.42756514
43Pyrimidine metabolism_Homo sapiens_hsa002401.34826050
44Cell cycle_Homo sapiens_hsa041101.31300361
45Renin secretion_Homo sapiens_hsa049241.31241073
46Ribosome_Homo sapiens_hsa030101.29195652
47Salivary secretion_Homo sapiens_hsa049701.27372070
48Cholinergic synapse_Homo sapiens_hsa047251.24566146
49Ether lipid metabolism_Homo sapiens_hsa005651.22715686
50Base excision repair_Homo sapiens_hsa034101.21060478
51Cocaine addiction_Homo sapiens_hsa050301.20033434
52Rheumatoid arthritis_Homo sapiens_hsa053231.17803019
53Axon guidance_Homo sapiens_hsa043601.13645813
54African trypanosomiasis_Homo sapiens_hsa051431.12204832
55SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11300216
56Olfactory transduction_Homo sapiens_hsa047401.11278432
57RNA polymerase_Homo sapiens_hsa030201.10555153
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09311608
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08811023
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08534589
61Gastric acid secretion_Homo sapiens_hsa049711.04734384
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03169037
63Calcium signaling pathway_Homo sapiens_hsa040201.01976464
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99962378
65Intestinal immune network for IgA production_Homo sapiens_hsa046720.98625920
66Folate biosynthesis_Homo sapiens_hsa007900.97711743
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96413995
68Oocyte meiosis_Homo sapiens_hsa041140.95276033
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87587463
70Sulfur metabolism_Homo sapiens_hsa009200.87382593
71Insulin secretion_Homo sapiens_hsa049110.81211779
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79827153
73Oxytocin signaling pathway_Homo sapiens_hsa049210.79372116
74Nitrogen metabolism_Homo sapiens_hsa009100.76690396
75Peroxisome_Homo sapiens_hsa041460.76378635
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75065074
77Phagosome_Homo sapiens_hsa041450.73391364
78Butanoate metabolism_Homo sapiens_hsa006500.68843333
79Primary immunodeficiency_Homo sapiens_hsa053400.68269033
80Gap junction_Homo sapiens_hsa045400.68050258
81Sphingolipid metabolism_Homo sapiens_hsa006000.66849839
82mRNA surveillance pathway_Homo sapiens_hsa030150.66570801
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.65915905
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63992915
85p53 signaling pathway_Homo sapiens_hsa041150.62993556
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62352849
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59149500
88Circadian rhythm_Homo sapiens_hsa047100.58966281
89Tryptophan metabolism_Homo sapiens_hsa003800.58793320
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57573975
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.55686112
92Selenocompound metabolism_Homo sapiens_hsa004500.54979590
93Pancreatic secretion_Homo sapiens_hsa049720.54656027
94GnRH signaling pathway_Homo sapiens_hsa049120.54001385
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51925393
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51246096
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50233026
98Melanogenesis_Homo sapiens_hsa049160.49880278
99Pyruvate metabolism_Homo sapiens_hsa006200.49839869
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48781290
101Autoimmune thyroid disease_Homo sapiens_hsa053200.48506687
102Type I diabetes mellitus_Homo sapiens_hsa049400.48182184
103Histidine metabolism_Homo sapiens_hsa003400.43147176
104Alcoholism_Homo sapiens_hsa050340.43028581
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42343596
106beta-Alanine metabolism_Homo sapiens_hsa004100.41441774
107Glycerolipid metabolism_Homo sapiens_hsa005610.41287860
108Allograft rejection_Homo sapiens_hsa053300.40640996
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.40572013
110Tyrosine metabolism_Homo sapiens_hsa003500.39888302
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.39827882
112Graft-versus-host disease_Homo sapiens_hsa053320.39277089
113Epstein-Barr virus infection_Homo sapiens_hsa051690.38532503
114Metabolic pathways_Homo sapiens_hsa011000.37273509
115Linoleic acid metabolism_Homo sapiens_hsa005910.36666471
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36000607
117Basal transcription factors_Homo sapiens_hsa030220.35516828
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34850808
119cAMP signaling pathway_Homo sapiens_hsa040240.33830977
120Arachidonic acid metabolism_Homo sapiens_hsa005900.33655481
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31873770
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.30929411
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29118405
124Fatty acid metabolism_Homo sapiens_hsa012120.28682707
125Estrogen signaling pathway_Homo sapiens_hsa049150.28296077
126Ras signaling pathway_Homo sapiens_hsa040140.28225902
127Dorso-ventral axis formation_Homo sapiens_hsa043200.28183775
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27970679
129Purine metabolism_Homo sapiens_hsa002300.27415512
130Regulation of autophagy_Homo sapiens_hsa041400.26525604
131Thyroid hormone synthesis_Homo sapiens_hsa049180.26237594
132Asthma_Homo sapiens_hsa053100.26071022
133Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25060620
134Glutathione metabolism_Homo sapiens_hsa004800.24957894
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24103680
136Dilated cardiomyopathy_Homo sapiens_hsa054140.23530414
137Phenylalanine metabolism_Homo sapiens_hsa003600.23411942
138Vitamin B6 metabolism_Homo sapiens_hsa007500.22712754
139Phospholipase D signaling pathway_Homo sapiens_hsa040720.22039343
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20082857
141Non-homologous end-joining_Homo sapiens_hsa034500.18528450
142Ovarian steroidogenesis_Homo sapiens_hsa049130.18467371
143ErbB signaling pathway_Homo sapiens_hsa040120.17769212
144Mineral absorption_Homo sapiens_hsa049780.15675336
145Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.13743691

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