GPAM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial enzyme which prefers saturated fatty acids as its substrate for the synthesis of glycerolipids. This metabolic pathway's first step is catalyzed by the encoded enzyme. Two forms for this enzyme exist, one in the mitochondria and one in the endoplasmic reticulum. Two alternatively spliced transcript variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1triglyceride catabolic process (GO:0019433)8.23171160
2alpha-linolenic acid metabolic process (GO:0036109)6.18027242
3diacylglycerol metabolic process (GO:0046339)6.06949003
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.04268148
5L-phenylalanine catabolic process (GO:0006559)6.04268148
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.77152331
7L-phenylalanine metabolic process (GO:0006558)5.77152331
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.57557774
9glycerolipid catabolic process (GO:0046503)5.52186529
10aromatic amino acid family catabolic process (GO:0009074)5.29610339
11* fatty acid homeostasis (GO:0055089)5.08674204
12fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.94692509
13ethanol metabolic process (GO:0006067)4.93539689
14glyoxylate metabolic process (GO:0046487)4.91720739
15kynurenine metabolic process (GO:0070189)4.91413760
16lysine catabolic process (GO:0006554)4.86878700
17lysine metabolic process (GO:0006553)4.86878700
18bile acid biosynthetic process (GO:0006699)4.86721721
19fatty-acyl-CoA biosynthetic process (GO:0046949)4.80639331
20NADH metabolic process (GO:0006734)4.80127286
21* triglyceride biosynthetic process (GO:0019432)4.79026879
22sulfur amino acid catabolic process (GO:0000098)4.78155846
23fatty-acyl-CoA metabolic process (GO:0035337)4.76378899
24tryptophan catabolic process (GO:0006569)4.68364580
25indole-containing compound catabolic process (GO:0042436)4.68364580
26indolalkylamine catabolic process (GO:0046218)4.68364580
27regulation of cholesterol storage (GO:0010885)4.68178637
28regulation of triglyceride catabolic process (GO:0010896)4.66114720
29brown fat cell differentiation (GO:0050873)4.65289159
30complement activation, alternative pathway (GO:0006957)4.64937835
31* neutral lipid biosynthetic process (GO:0046460)4.63675391
32* acylglycerol biosynthetic process (GO:0046463)4.63675391
33cysteine metabolic process (GO:0006534)4.61914345
34lipid storage (GO:0019915)4.59736721
35urea cycle (GO:0000050)4.59517931
36urea metabolic process (GO:0019627)4.59517931
37* triglyceride metabolic process (GO:0006641)4.55653139
38positive regulation of fatty acid beta-oxidation (GO:0032000)4.52829174
39high-density lipoprotein particle remodeling (GO:0034375)4.45385233
40acetyl-CoA metabolic process (GO:0006084)4.45180032
41tryptophan metabolic process (GO:0006568)4.43435394
42negative regulation of fibrinolysis (GO:0051918)4.41531411
43amino-acid betaine metabolic process (GO:0006577)4.41307893
44regulation of protein activation cascade (GO:2000257)4.40848145
45primary alcohol metabolic process (GO:0034308)4.39871172
46fatty acid transmembrane transport (GO:1902001)4.37327942
47long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.36590076
48serine family amino acid catabolic process (GO:0009071)4.32190959
49fatty acid beta-oxidation (GO:0006635)4.31619895
50oxaloacetate metabolic process (GO:0006107)4.30944227
51ethanol oxidation (GO:0006069)4.28937828
52protein carboxylation (GO:0018214)4.28592514
53peptidyl-glutamic acid carboxylation (GO:0017187)4.28592514
54plasma lipoprotein particle clearance (GO:0034381)4.26380616
55* acylglycerol metabolic process (GO:0006639)4.25379353
56regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)4.23833801
57cellular ketone body metabolic process (GO:0046950)4.21972297
582-oxoglutarate metabolic process (GO:0006103)4.21779942
59bile acid metabolic process (GO:0008206)4.21600581
60nitrogen cycle metabolic process (GO:0071941)4.21102003
61positive regulation of lipid storage (GO:0010884)4.19872130
62* neutral lipid metabolic process (GO:0006638)4.18982897
63reverse cholesterol transport (GO:0043691)4.17636030
64homocysteine metabolic process (GO:0050667)4.17366867
65tricarboxylic acid metabolic process (GO:0072350)4.17003405
66regulation of complement activation (GO:0030449)4.16308223
67regulation of fibrinolysis (GO:0051917)4.15315014
68acylglycerol homeostasis (GO:0055090)4.15107430
69triglyceride homeostasis (GO:0070328)4.15107430
70short-chain fatty acid metabolic process (GO:0046459)4.13648773
71lipid particle organization (GO:0034389)4.10548609
72carnitine shuttle (GO:0006853)4.07739627
73response to phenylpropanoid (GO:0080184)4.07337859
74fatty acid oxidation (GO:0019395)4.07053004
75white fat cell differentiation (GO:0050872)4.06678678
76alpha-amino acid catabolic process (GO:1901606)4.05596327
77valine metabolic process (GO:0006573)4.05116364
78positive regulation of lipid catabolic process (GO:0050996)4.03056843
79lipid oxidation (GO:0034440)4.01680209
80plasma lipoprotein particle remodeling (GO:0034369)4.01394472
81protein-lipid complex remodeling (GO:0034368)4.01394472
82macromolecular complex remodeling (GO:0034367)4.01394472
83dicarboxylic acid biosynthetic process (GO:0043650)3.98683104
84fatty acid catabolic process (GO:0009062)3.96698792
85positive regulation of fatty acid oxidation (GO:0046321)3.96130623
86* acyl-CoA metabolic process (GO:0006637)3.94224809
87* thioester metabolic process (GO:0035383)3.94224809
88long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.91145526
89positive regulation of cholesterol efflux (GO:0010875)3.90915136
90biotin metabolic process (GO:0006768)3.90805008
91regulation of fatty acid beta-oxidation (GO:0031998)3.90599924
92regulation of cholesterol esterification (GO:0010872)3.89189902
93glycerol metabolic process (GO:0006071)3.86703889
94tyrosine metabolic process (GO:0006570)3.85165273
95cellular amino acid catabolic process (GO:0009063)3.84055628
96monocarboxylic acid catabolic process (GO:0072329)3.83580325
97polyketide metabolic process (GO:0030638)3.83577849
98doxorubicin metabolic process (GO:0044598)3.83577849
99daunorubicin metabolic process (GO:0044597)3.83577849
100regulation of glycogen (starch) synthase activity (GO:2000465)3.82239424
101phospholipid efflux (GO:0033700)3.80960411
102aromatic amino acid family metabolic process (GO:0009072)3.78753453
103negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.77543752
104aspartate family amino acid catabolic process (GO:0009068)3.77321067
105cellular modified amino acid catabolic process (GO:0042219)3.76223801
106glutamate metabolic process (GO:0006536)3.76210089
107positive regulation of triglyceride lipase activity (GO:0061365)3.74501658
108positive regulation of lipoprotein lipase activity (GO:0051006)3.74501658
109response to dietary excess (GO:0002021)3.72700308
110regulation of sequestering of triglyceride (GO:0010889)3.71252223
111coenzyme catabolic process (GO:0009109)3.71208622
112regulation of cAMP-dependent protein kinase activity (GO:2000479)3.67070016
113ketone body metabolic process (GO:1902224)3.66986226
114negative regulation of cholesterol transport (GO:0032375)3.66541737
115negative regulation of sterol transport (GO:0032372)3.66541737
116regulation of cholesterol homeostasis (GO:2000188)3.65431297
117carnitine metabolic process (GO:0009437)3.64143444
118retinol metabolic process (GO:0042572)3.63508306
119positive regulation of cholesterol transport (GO:0032376)3.63112548
120positive regulation of sterol transport (GO:0032373)3.63112548
121organic acid catabolic process (GO:0016054)3.61604430
122carboxylic acid catabolic process (GO:0046395)3.61604430
123low-density lipoprotein particle clearance (GO:0034383)3.56271836
124linoleic acid metabolic process (GO:0043651)3.56040241
125plasma lipoprotein particle assembly (GO:0034377)3.53612572
126alditol metabolic process (GO:0019400)3.53210926
127positive regulation of glycolytic process (GO:0045821)3.51647817
128cholesterol efflux (GO:0033344)3.51173770
129branched-chain amino acid catabolic process (GO:0009083)3.50826483
130regulation of triglyceride metabolic process (GO:0090207)3.50167967
131regulation of fatty acid oxidation (GO:0046320)3.47502020
132glycine metabolic process (GO:0006544)3.45427390
133thioester biosynthetic process (GO:0035384)3.45387776
134acyl-CoA biosynthetic process (GO:0071616)3.45387776
135positive regulation of fatty acid metabolic process (GO:0045923)3.45189643
136low-density lipoprotein particle remodeling (GO:0034374)3.44171935
137negative regulation of lipase activity (GO:0060192)3.43670021
138bile acid and bile salt transport (GO:0015721)3.41306122
139regulation of cholesterol metabolic process (GO:0090181)3.40876681
140positive regulation of triglyceride metabolic process (GO:0090208)3.38834670
141serine family amino acid metabolic process (GO:0009069)3.38220222
142acylglycerol catabolic process (GO:0046464)3.37757167
143neutral lipid catabolic process (GO:0046461)3.37757167
144regulation of cholesterol transport (GO:0032374)3.36706690
145regulation of sterol transport (GO:0032371)3.36706690
146protein heterotrimerization (GO:0070208)3.36488039
147branched-chain amino acid metabolic process (GO:0009081)3.35855006
148aminoglycoside antibiotic metabolic process (GO:0030647)3.34806345
149cellular glucuronidation (GO:0052695)3.34222159
150benzene-containing compound metabolic process (GO:0042537)3.33771383
151very-low-density lipoprotein particle assembly (GO:0034379)3.33076392
152regulation of macrophage derived foam cell differentiation (GO:0010743)3.31873037
153primary alcohol catabolic process (GO:0034310)3.30437487
154regulation of triglyceride biosynthetic process (GO:0010866)3.30010858
155polyol transport (GO:0015791)3.22766813
156transcytosis (GO:0045056)3.20880628
157L-serine transport (GO:0015825)3.18923259

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.68841393
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.96139396
3* RXR_22158963_ChIP-Seq_LIVER_Mouse6.94641980
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.02767474
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.65464440
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.97329007
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.49403885
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.90493385
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.43520510
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.11659756
11CLOCK_20551151_ChIP-Seq_293T_Human2.54789835
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.49120223
13* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.88738661
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.80400146
15GATA1_22025678_ChIP-Seq_K562_Human1.62777446
16TP63_17297297_ChIP-ChIP_HaCaT_Human1.59670509
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50745676
18RARG_19884340_ChIP-ChIP_MEFs_Mouse1.50429587
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.48599027
20ZNF263_19887448_ChIP-Seq_K562_Human1.48217484
21ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.39961041
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39008674
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.30652300
24HNF4A_19822575_ChIP-Seq_HepG2_Human1.29198326
25BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29089638
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.27868070
27* PIAS1_25552417_ChIP-Seq_VCAP_Human1.26485747
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25344448
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24040181
30NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16858529
31TBX20_22080862_ChIP-Seq_HEART_Mouse1.13315024
32TBX20_22328084_ChIP-Seq_HEART_Mouse1.13315024
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12230181
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.11437209
35* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09398339
36HTT_18923047_ChIP-ChIP_STHdh_Human1.06521400
37ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06012004
38GBX2_23144817_ChIP-Seq_PC3_Human1.05606230
39CJUN_26792858_Chip-Seq_BT549_Human1.04743563
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99833831
41SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98504076
42PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98001571
43AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95886136
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94343428
45* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92619923
46EP300_21415370_ChIP-Seq_HL-1_Mouse0.91598399
47FOXO3_23340844_ChIP-Seq_DLD1_Human0.90975827
48TCF4_18268006_ChIP-ChIP_LS174T_Human0.90140347
49CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88556752
50WT1_19549856_ChIP-ChIP_CCG9911_Human0.87675115
51IGF1R_20145208_ChIP-Seq_DFB_Human0.87541501
52NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85600693
53NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85600693
54* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85128039
55TRIM28_21343339_ChIP-Seq_HEK293_Human0.84650102
56ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83651207
57EOMES_21245162_ChIP-Seq_HESCs_Human0.82856790
58PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82143780
59RXRA_24833708_ChIP-Seq_LIVER_Mouse0.81604652
60EZH2_18974828_ChIP-Seq_MESCs_Mouse0.81291705
61RNF2_18974828_ChIP-Seq_MESCs_Mouse0.81291705
62LXR_22292898_ChIP-Seq_THP-1_Human0.81264273
63* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81073544
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.80536804
65* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.79851013
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.79763602
67ESR1_21235772_ChIP-Seq_MCF-7_Human0.79369563
68GATA1_19941826_ChIP-Seq_K562_Human0.79214409
69AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78626837
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.77172179
71* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.75695722
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.75521767
73SA1_22415368_ChIP-Seq_MEFs_Mouse0.75375257
74NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.75274011
75GATA4_25053715_ChIP-Seq_YYC3_Human0.75180289
76HIF1A_21447827_ChIP-Seq_MCF-7_Human0.74806188
77SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74242293
78SOX2_20726797_ChIP-Seq_SW620_Human0.73636100
79BCAT_22108803_ChIP-Seq_LS180_Human0.72351419
80RBPJ_22232070_ChIP-Seq_NCS_Mouse0.71998916
81* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71384879
82* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.71052966
83NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.69442480
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.69032993
85* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.68933859
86* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.68185355
87SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.67568736
88ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.66507676
89Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.66018032
90EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.65709332
91SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.65678603
92MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.65063959
93GATA2_19941826_ChIP-Seq_K562_Human0.64960459
94CDX2_19796622_ChIP-Seq_MESCs_Mouse0.62181879
95GATA4_21415370_ChIP-Seq_HL-1_Mouse0.61447489
96WT1_25993318_ChIP-Seq_PODOCYTE_Human0.60744513
97ERG_21242973_ChIP-ChIP_JURKAT_Human0.60650091
98IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.60596653
99AR_21909140_ChIP-Seq_LNCAP_Human0.60586481
100SOX9_24532713_ChIP-Seq_HFSC_Mouse0.59558797
101CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.58531726
102RACK7_27058665_Chip-Seq_MCF-7_Human0.58334040
103FOXA1_25552417_ChIP-Seq_VCAP_Human0.58218109
104HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.57757988
105ISL1_27105846_Chip-Seq_CPCs_Mouse0.57311991
106MTF2_20144788_ChIP-Seq_MESCs_Mouse0.56792902
107ZNF217_24962896_ChIP-Seq_MCF-7_Human0.56156626
108SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.55643097
109EED_16625203_ChIP-ChIP_MESCs_Mouse0.55051869
110FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.54167086
111* CEBPB_22108803_ChIP-Seq_LS180_Human0.54061759
112RAD21_21589869_ChIP-Seq_MESCs_Mouse0.53930727
113CREB1_26743006_Chip-Seq_LNCaP_Human0.53835075
114GATA2_21666600_ChIP-Seq_HMVEC_Human0.53654618
115SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.53221156
116* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.53217984
117SOX11_22085726_ChIP-Seq_ESNs_Mouse0.52937797
118* CBP_21632823_ChIP-Seq_H3396_Human0.52634860
119TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.52560514
120P300_27058665_Chip-Seq_ZR-75-30cells_Human0.52336612
121* GATA1_19941827_ChIP-Seq_MEL_Mouse0.52180351
122SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.51632608
123* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.51322912
124CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.51040246
125PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.50859395
126SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.50777232
127SMAD4_21741376_ChIP-Seq_HESCs_Human0.49978275
128GATA3_24758297_ChIP-Seq_MCF-7_Human0.49311549
129EGR1_19032775_ChIP-ChIP_M12_Human0.48443647
130* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.48131682
131* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.47755651
132RARA_24833708_ChIP-Seq_LIVER_Mouse0.47421460
133CDX2_20551321_ChIP-Seq_CACO-2_Human0.47364063
134DROSHA_22980978_ChIP-Seq_HELA_Human0.46675881
135NFIB_24661679_ChIP-Seq_LUNG_Mouse0.46656032
136* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.46654788
137CTCF_27219007_Chip-Seq_Bcells_Human0.46123218

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.14880974
2MP0005360_urolithiasis6.27553880
3MP0005365_abnormal_bile_salt5.48078396
4MP0005085_abnormal_gallbladder_physiolo5.34300747
5MP0008875_abnormal_xenobiotic_pharmacok3.93965265
6* MP0010329_abnormal_lipoprotein_level3.56371636
7MP0003252_abnormal_bile_duct3.42421094
8MP0003806_abnormal_nucleotide_metabolis3.41909817
9MP0009840_abnormal_foam_cell2.96073679
10MP0005083_abnormal_biliary_tract2.78162308
11MP0005670_abnormal_white_adipose2.75008572
12MP0005332_abnormal_amino_acid2.56377444
13MP0002837_dystrophic_cardiac_calcinosis2.52274003
14MP0004130_abnormal_muscle_cell2.50288994
15MP0003191_abnormal_cellular_cholesterol2.40097533
16* MP0002118_abnormal_lipid_homeostasis2.32632528
17MP0001666_abnormal_nutrient_absorption2.19807925
18* MP0000609_abnormal_liver_physiology2.07051944
19MP0003195_calcinosis2.05905097
20MP0005666_abnormal_adipose_tissue1.96244946
21MP0003705_abnormal_hypodermis_morpholog1.85138530
22MP0005319_abnormal_enzyme/_coenzyme1.75276616
23MP0004272_abnormal_basement_membrane1.71404624
24MP0004019_abnormal_vitamin_homeostasis1.69070298
25MP0005584_abnormal_enzyme/coenzyme_acti1.59599879
26MP0002971_abnormal_brown_adipose1.53489220
27MP0003646_muscle_fatigue1.46160169
28* MP0005452_abnormal_adipose_tissue1.43806086
29MP0003868_abnormal_feces_composition1.40111310
30MP0003828_pulmonary_edema1.39857826
31MP0004185_abnormal_adipocyte_glucose1.38489870
32MP0002138_abnormal_hepatobiliary_system1.32920580
33MP0003011_delayed_dark_adaptation1.30395447
34MP0003950_abnormal_plasma_membrane1.27153956
35MP0005375_adipose_tissue_phenotype1.22542086
36MP0005503_abnormal_tendon_morphology1.20839433
37MP0003690_abnormal_glial_cell1.18821621
38MP0002254_reproductive_system_inflammat1.18112782
39MP0001764_abnormal_homeostasis1.17575113
40MP0005647_abnormal_sex_gland1.17528756
41MP0009643_abnormal_urine_homeostasis1.17104057
42MP0006036_abnormal_mitochondrial_physio1.15501881
43MP0001661_extended_life_span1.14702527
44* MP0005334_abnormal_fat_pad1.14206757
45MP0000604_amyloidosis1.13824246
46MP0000751_myopathy1.12766945
47MP0005330_cardiomyopathy1.07109542
48MP0005535_abnormal_body_temperature1.05359421
49* MP0002078_abnormal_glucose_homeostasis1.05131265
50MP0008438_abnormal_cutaneous_collagen1.03995814
51MP0010368_abnormal_lymphatic_system1.03811293
52MP0003186_abnormal_redox_activity1.03576500
53MP0003329_amyloid_beta_deposits1.00597341
54MP0002638_abnormal_pupillary_reflex0.97571026
55MP0001881_abnormal_mammary_gland0.97465491
56MP0003656_abnormal_erythrocyte_physiolo0.95429588
57* MP0000598_abnormal_liver_morphology0.95356883
58MP0004036_abnormal_muscle_relaxation0.95133383
59MP0005451_abnormal_body_composition0.94761981
60MP0005379_endocrine/exocrine_gland_phen0.93036196
61MP0009115_abnormal_fat_cell0.93029788
62MP0002108_abnormal_muscle_morphology0.92416493
63MP0002269_muscular_atrophy0.90740587
64MP0003948_abnormal_gas_homeostasis0.89538940
65MP0004215_abnormal_myocardial_fiber0.89314754
66MP0004087_abnormal_muscle_fiber0.87288207
67MP0009697_abnormal_copulation0.86178604
68MP0005164_abnormal_response_to0.84055569
69MP0000343_altered_response_to0.81948911
70MP0002876_abnormal_thyroid_physiology0.81649234
71MP0005448_abnormal_energy_balance0.81636551
72MP0009763_increased_sensitivity_to0.80697419
73MP0004084_abnormal_cardiac_muscle0.77857706
74* MP0009642_abnormal_blood_homeostasis0.74623331
75MP0002970_abnormal_white_adipose0.74380864
76MP0000759_abnormal_skeletal_muscle0.74225282
77MP0009780_abnormal_chondrocyte_physiolo0.73680183
78MP0009764_decreased_sensitivity_to0.73272398
79MP0000749_muscle_degeneration0.73249426
80MP0006138_congestive_heart_failure0.72331743
81MP0005620_abnormal_muscle_contractility0.71096535
82MP0005266_abnormal_metabolism0.69736939
83MP0001544_abnormal_cardiovascular_syste0.68896685
84MP0005385_cardiovascular_system_phenoty0.68896685
85MP0001756_abnormal_urination0.67347307
86MP0000249_abnormal_blood_vessel0.67174370
87MP0005595_abnormal_vascular_smooth0.67107981
88MP0009384_cardiac_valve_regurgitation0.66218155
89MP0005376_homeostasis/metabolism_phenot0.66201755
90MP0005275_abnormal_skin_tensile0.65498563
91MP0006035_abnormal_mitochondrial_morpho0.64065236
92MP0000747_muscle_weakness0.63421060
93MP0000013_abnormal_adipose_tissue0.63398136
94MP0005636_abnormal_mineral_homeostasis0.63078327
95MP0001177_atelectasis0.62873988
96MP0000003_abnormal_adipose_tissue0.62849894
97MP0008775_abnormal_heart_ventricle0.61926695
98MP0010630_abnormal_cardiac_muscle0.61797652
99MP0004782_abnormal_surfactant_physiolog0.61273421
100MP0002295_abnormal_pulmonary_circulatio0.60818071
101MP0002972_abnormal_cardiac_muscle0.60045643
102MP0001879_abnormal_lymphatic_vessel0.58328292
103MP0000767_abnormal_smooth_muscle0.57161055
104MP0003566_abnormal_cell_adhesion0.56650889
105MP0000230_abnormal_systemic_arterial0.54968605
106MP0003279_aneurysm0.54792703
107* MP0003953_abnormal_hormone_level0.54380013
108MP0002909_abnormal_adrenal_gland0.54274688
109MP0001915_intracranial_hemorrhage0.53903177
110MP0002168_other_aberrant_phenotype0.53826959
111MP0008961_abnormal_basal_metabolism0.53529574
112MP0003075_altered_response_to0.53040485
113MP0002332_abnormal_exercise_endurance0.52913050
114MP0008469_abnormal_protein_level0.52889743
115MP0002796_impaired_skin_barrier0.52052245
116MP0003300_gastrointestinal_ulcer0.50281409
117MP0005167_abnormal_blood-brain_barrier0.50121062
118MP0001944_abnormal_pancreas_morphology0.49599876
119MP0001727_abnormal_embryo_implantation0.49325171
120MP0003724_increased_susceptibility_to0.48954869
121MP0002090_abnormal_vision0.47490009
122MP0009672_abnormal_birth_weight0.47227520
123MP0000639_abnormal_adrenal_gland0.46262698
124MP0005220_abnormal_exocrine_pancreas0.45987343
125MP0003959_abnormal_lean_body0.45938093
126MP0009703_decreased_birth_body0.45303163
127MP0008874_decreased_physiological_sensi0.44761141
128MP0003879_abnormal_hair_cell0.44382506
129MP0006276_abnormal_autonomic_nervous0.43647744
130MP0002128_abnormal_blood_circulation0.43425243
131MP0005388_respiratory_system_phenotype0.39920142
132MP0002133_abnormal_respiratory_system0.39920142

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.16407191
2Intrahepatic cholestasis (HP:0001406)5.88368013
3Xanthomatosis (HP:0000991)5.69374559
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.38407822
5Hyperlipoproteinemia (HP:0010980)4.93328800
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.93137467
7Hypobetalipoproteinemia (HP:0003563)4.87573423
8Hyperglycinuria (HP:0003108)4.77247182
9Complement deficiency (HP:0004431)4.72745084
10Prolonged partial thromboplastin time (HP:0003645)4.71454205
11Hyperammonemia (HP:0001987)4.62838465
12Ketosis (HP:0001946)4.60190584
13Abnormality of serine family amino acid metabolism (HP:0010894)4.51439288
14Abnormality of glycine metabolism (HP:0010895)4.51439288
15Hypoglycemic coma (HP:0001325)4.49898681
16Hypoalphalipoproteinemia (HP:0003233)4.47648739
17Hyperglycinemia (HP:0002154)4.42101022
18Hypolipoproteinemia (HP:0010981)4.39878157
19Epidermoid cyst (HP:0200040)4.30184855
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.07790989
21Increased serum pyruvate (HP:0003542)4.00790971
22Ketoacidosis (HP:0001993)3.92788547
23Abnormality of fatty-acid metabolism (HP:0004359)3.85925327
24Protrusio acetabuli (HP:0003179)3.85298387
25Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.62465520
26Abnormality of glutamine family amino acid metabolism (HP:0010902)3.61243830
27Abnormality of glycolysis (HP:0004366)3.49615031
28Abnormality of the common coagulation pathway (HP:0010990)3.45718072
29Joint hemorrhage (HP:0005261)3.40853555
30Glomerulonephritis (HP:0000099)3.38826070
31Abnormality of sulfur amino acid metabolism (HP:0004339)3.35214656
32Hypercholesterolemia (HP:0003124)3.31902927
33Abnormality of complement system (HP:0005339)3.29638124
34Abnormality of aspartate family amino acid metabolism (HP:0010899)3.27707251
35Insulin resistance (HP:0000855)3.25988035
36Myoglobinuria (HP:0002913)3.17449422
37Abnormality of methionine metabolism (HP:0010901)3.15601233
38Increased variability in muscle fiber diameter (HP:0003557)3.11037212
39Fat malabsorption (HP:0002630)3.10406197
40Dicarboxylic aciduria (HP:0003215)3.04510265
41Abnormality of dicarboxylic acid metabolism (HP:0010995)3.04510265
42Difficulty running (HP:0009046)3.00766239
43Skin nodule (HP:0200036)3.00508841
44Abnormality of the intrinsic pathway (HP:0010989)2.94000740
45Abnormality of serum amino acid levels (HP:0003112)2.87729353
46Abnormality of alanine metabolism (HP:0010916)2.84849836
47Hyperalaninemia (HP:0003348)2.84849836
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.84849836
49Myocardial infarction (HP:0001658)2.83230947
50Hyperbilirubinemia (HP:0002904)2.75160550
51Metabolic acidosis (HP:0001942)2.72796104
52Delayed CNS myelination (HP:0002188)2.68263837
53Insulin-resistant diabetes mellitus (HP:0000831)2.67256953
54Vertebral compression fractures (HP:0002953)2.65314906
55Abnormality of purine metabolism (HP:0004352)2.64714023
56Conjugated hyperbilirubinemia (HP:0002908)2.61639258
57Hypoglycemic seizures (HP:0002173)2.61374355
58Pigmentary retinal degeneration (HP:0001146)2.57943507
59Gout (HP:0001997)2.55298955
60Hepatocellular carcinoma (HP:0001402)2.53731717
61Potter facies (HP:0002009)2.53673367
62Facial shape deformation (HP:0011334)2.53673367
63Abnormality of skeletal muscle fiber size (HP:0012084)2.49785405
64Abnormality of nucleobase metabolism (HP:0010932)2.49628176
65Cholelithiasis (HP:0001081)2.49573735
66Abnormal gallbladder morphology (HP:0012437)2.48280491
67Exercise-induced myalgia (HP:0003738)2.42338082
68Lethargy (HP:0001254)2.42246816
69Hyperinsulinemic hypoglycemia (HP:0000825)2.38333564
70Hypertriglyceridemia (HP:0002155)2.36752759
71Growth hormone excess (HP:0000845)2.33872312
72Nephritis (HP:0000123)2.32435009
73Rickets (HP:0002748)2.32149577
74Rhabdomyolysis (HP:0003201)2.31601724
75Long foot (HP:0001833)2.29765703
76Mitral stenosis (HP:0001718)2.26124269
77Hydroxyprolinuria (HP:0003080)2.25014511
78Abnormality of proline metabolism (HP:0010907)2.25014511
79Cerebral edema (HP:0002181)2.23591481
80Late onset (HP:0003584)2.23050818
81Spastic diplegia (HP:0001264)2.19872187
82Abnormality of pyrimidine metabolism (HP:0004353)2.19456482
83Sensorimotor neuropathy (HP:0007141)2.19209912
84Hyperglycemia (HP:0003074)2.18208971
85Subcapsular cataract (HP:0000523)2.18127804
86Infantile muscular hypotonia (HP:0008947)2.17183762
87Steatorrhea (HP:0002570)2.15609174
88Acanthocytosis (HP:0001927)2.14395005
89Generalized aminoaciduria (HP:0002909)2.13444258
90Esophageal varix (HP:0002040)2.10918457
91Cholecystitis (HP:0001082)2.09506232
92Abnormal gallbladder physiology (HP:0012438)2.09506232
93Abnormal cartilage morphology (HP:0002763)2.08833307
94Hemorrhage of the eye (HP:0011885)2.08082137
95Vomiting (HP:0002013)2.05253134
96Systemic lupus erythematosus (HP:0002725)2.04807807
97Increased muscle lipid content (HP:0009058)2.04665234
98Ectopia lentis (HP:0001083)2.04228915
99Abnormality of carpal bone ossification (HP:0006257)2.04067231
100Hypochromic microcytic anemia (HP:0004840)2.03456048
101Vascular calcification (HP:0004934)2.03024112
102Right ventricular cardiomyopathy (HP:0011663)2.03008639
103Neonatal onset (HP:0003623)2.02895659
104Premature rupture of membranes (HP:0001788)2.02294029
105Increased mean platelet volume (HP:0011877)2.01306179
106Hypophosphatemic rickets (HP:0004912)2.00709931
107Hyperuricemia (HP:0002149)1.98609353
108Increased purine levels (HP:0004368)1.98609353
109Prominent supraorbital ridges (HP:0000336)1.98585882
110Spontaneous abortion (HP:0005268)1.98239711
111Pancreatitis (HP:0001733)1.98013404
112Oligomenorrhea (HP:0000876)1.92538669
113Amyloidosis (HP:0011034)1.92418651
114Cardiovascular calcification (HP:0011915)1.91747572
115Hyporeflexia of lower limbs (HP:0002600)1.91584140
116Exercise-induced muscle cramps (HP:0003710)1.90032197
117Abnormality of the gallbladder (HP:0005264)1.89161844
118Reduced subcutaneous adipose tissue (HP:0003758)1.87817171
119Lymphangioma (HP:0100764)1.85042435
120Renal cortical cysts (HP:0000803)1.84504634
121Turricephaly (HP:0000262)1.84347877
122Irritability (HP:0000737)1.84195517
123Spinal rigidity (HP:0003306)1.83086041
124Acanthosis nigricans (HP:0000956)1.83048008
125Coronal craniosynostosis (HP:0004440)1.82792963
126Back pain (HP:0003418)1.82157150
127Polycythemia (HP:0001901)1.82018092
128Abnormal hemoglobin (HP:0011902)1.81957095
129Atrioventricular block (HP:0001678)1.81950469
130Brushfield spots (HP:0001088)1.81800771
131Accelerated skeletal maturation (HP:0005616)1.81597925
132Vascular tortuosity (HP:0004948)1.81144030
133Malnutrition (HP:0004395)1.80672321
134Proximal tubulopathy (HP:0000114)1.79229153
135Aortic aneurysm (HP:0004942)1.77618865
136Bone cyst (HP:0012062)1.77426359
137Striae distensae (HP:0001065)1.77393269
138Enlarged kidneys (HP:0000105)1.75901058
139Abnormality of the lower motor neuron (HP:0002366)1.75303521
140Sudden death (HP:0001699)1.74762147
141Nausea (HP:0002018)1.74710585
142Tetraparesis (HP:0002273)1.74209711
143Axonal loss (HP:0003447)1.72734204
144Hypercortisolism (HP:0001578)1.69590786
145Abnormal delivery (HP:0001787)1.69118046
146Abnormal eating behavior (HP:0100738)1.68752105

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.23442436
2SIK14.48792777
3TRIB34.08214904
4EPHB23.10125703
5LMTK22.85332864
6ERN12.80898676
7PKN22.80679375
8FGFR42.65797500
9CAMK1D2.65072796
10INSRR2.34781885
11PDK32.18022197
12PDK42.18022197
13TTN2.10942758
14PHKG12.04275234
15PHKG22.04275234
16CAMK1G1.94824254
17CAMK11.93986671
18RIPK11.91723893
19FGFR21.89121335
20LATS11.73751422
21MAP3K61.66333987
22OBSCN1.59058623
23MST1R1.49984660
24PINK11.45944450
25MAP2K41.45358573
26CAMKK21.43819004
27PRKAA21.43589423
28MAP3K71.42466837
29MAP3K101.41871999
30NLK1.35595548
31PTK61.27816493
32TESK11.27712326
33MAPK111.24246715
34AKT31.22213251
35PIK3CG1.19314605
36FRK1.18355837
37PDK21.17418915
38DAPK21.15861924
39ERBB41.15058563
40PDGFRA1.10525978
41FLT31.10287505
42PRKAA11.09969889
43MAPK121.02647504
44PIK3CA1.02501216
45TIE11.02217380
46FGFR31.00480563
47CDK90.94044296
48TAOK30.93931341
49NEK90.93575304
50JAK10.93538463
51SGK30.87889466
52JAK20.86786309
53PAK20.86547734
54TYRO30.86495857
55PRPF4B0.86355200
56SCYL20.85693279
57EPHB10.79623767
58RET0.79188386
59NEK10.78309136
60PTK20.75185009
61MAP2K30.74721679
62PDPK10.73978490
63PRKACG0.71273004
64PAK30.70964845
65EPHA40.70523221
66ICK0.70147230
67MET0.68544931
68MYLK0.68489309
69PRKD10.67624575
70CDK60.67600776
71TGFBR20.67348868
72NTRK10.67251220
73PRKG10.66192945
74MAP2K10.63295577
75TYK20.62819752
76ARAF0.60298568
77MTOR0.60168982
78AKT20.59385653
79STK38L0.58235892
80YES10.56755491
81PDK10.56046771
82SGK20.54912525
83MAPK30.54718070
84ERBB20.54416320
85PRKCH0.54137889
86MAPK40.53730408
87PRKACB0.53081808
88LATS20.52310124
89ABL20.51633210
90PRKCZ0.51229214
91KSR20.50293482
92STK380.49979454
93GSK3A0.48834946
94SGK2230.47738956
95SGK4940.47738956
96KDR0.46221146
97FGFR10.45184825
98NTRK30.44488276
99STK30.44110754
100BMX0.43986870
101MOS0.43691175
102GRK50.42854453
103INSR0.42837141
104MAP3K30.42285378
105MAPKAPK30.41853576
106DDR20.41440256
107EPHA30.40680391
108DMPK0.40658981
109DYRK1B0.40163312
110EEF2K0.40134751
111GRK60.39806223
112FER0.39289172
113PRKACA0.38243298
114ROCK10.37518432
115MAPK70.37149529
116ERBB30.37026665
117IGF1R0.36775194
118CAMK40.36409427
119TRPM70.36388283
120PKN10.36156314
121CAMKK10.34877320
122ADRBK10.34840752
123PDGFRB0.34717206
124CAMK2G0.33129287
125CLK10.32750940
126MAP3K40.32267310
127MAPK10.30965774
128RPS6KA30.30804069
129ILK0.30056650
130LRRK20.30031815
131CDK40.29104880
132CSNK1E0.28285713
133CDK50.27519920
134PRKD30.27097762
135EIF2AK20.26332821
136PAK60.26226065
137SRC0.26110238
138MARK10.24920079

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.85550096
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.70807227
3Fatty acid degradation_Homo sapiens_hsa000713.13540845
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.05700149
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.90674073
6Propanoate metabolism_Homo sapiens_hsa006402.88578025
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.75990053
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.75651405
9Arginine biosynthesis_Homo sapiens_hsa002202.72653732
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.67970740
11Fatty acid metabolism_Homo sapiens_hsa012122.65381302
12Tryptophan metabolism_Homo sapiens_hsa003802.47412438
13PPAR signaling pathway_Homo sapiens_hsa033202.44478406
14Butanoate metabolism_Homo sapiens_hsa006502.32111933
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.28635468
16Complement and coagulation cascades_Homo sapiens_hsa046102.16698617
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.06263327
18Peroxisome_Homo sapiens_hsa041462.00996289
19beta-Alanine metabolism_Homo sapiens_hsa004101.82770917
20Pyruvate metabolism_Homo sapiens_hsa006201.79939566
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.78524616
22Fatty acid biosynthesis_Homo sapiens_hsa000611.78354906
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.77697416
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.64568952
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58081374
26Carbon metabolism_Homo sapiens_hsa012001.57991921
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.57107188
28Fatty acid elongation_Homo sapiens_hsa000621.52157860
29Caffeine metabolism_Homo sapiens_hsa002321.50249416
30Bile secretion_Homo sapiens_hsa049761.45621659
31Chemical carcinogenesis_Homo sapiens_hsa052041.45243198
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.42649899
33Histidine metabolism_Homo sapiens_hsa003401.41192157
34Phenylalanine metabolism_Homo sapiens_hsa003601.36017342
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.35427788
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.33852188
37Starch and sucrose metabolism_Homo sapiens_hsa005001.31919122
38Staphylococcus aureus infection_Homo sapiens_hsa051501.30682946
39Retinol metabolism_Homo sapiens_hsa008301.29976621
40Biosynthesis of amino acids_Homo sapiens_hsa012301.23836858
41Fat digestion and absorption_Homo sapiens_hsa049751.23069963
42Tyrosine metabolism_Homo sapiens_hsa003501.21702796
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21524041
44ABC transporters_Homo sapiens_hsa020101.18968594
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.18904644
46Selenocompound metabolism_Homo sapiens_hsa004501.16671950
47Sulfur metabolism_Homo sapiens_hsa009201.04844972
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03285073
49Lysine degradation_Homo sapiens_hsa003101.01544114
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.98611837
51* Glycerolipid metabolism_Homo sapiens_hsa005610.96952826
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88300951
53Vitamin B6 metabolism_Homo sapiens_hsa007500.82914616
54Steroid biosynthesis_Homo sapiens_hsa001000.82798012
55Arginine and proline metabolism_Homo sapiens_hsa003300.81576236
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75897559
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.75198133
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66753890
59ECM-receptor interaction_Homo sapiens_hsa045120.66400885
60Sulfur relay system_Homo sapiens_hsa041220.65866970
61Insulin resistance_Homo sapiens_hsa049310.65821940
62Vitamin digestion and absorption_Homo sapiens_hsa049770.64917984
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.61699175
64Folate biosynthesis_Homo sapiens_hsa007900.61464307
65Pentose phosphate pathway_Homo sapiens_hsa000300.58681722
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57793864
67Renin-angiotensin system_Homo sapiens_hsa046140.52078557
68AMPK signaling pathway_Homo sapiens_hsa041520.49984767
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.49454245
70Glucagon signaling pathway_Homo sapiens_hsa049220.48889291
71Glutathione metabolism_Homo sapiens_hsa004800.40069989
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39451906
73Insulin signaling pathway_Homo sapiens_hsa049100.36451443
74* Metabolic pathways_Homo sapiens_hsa011000.34416901
75Fructose and mannose metabolism_Homo sapiens_hsa000510.29664378
76Galactose metabolism_Homo sapiens_hsa000520.26399585
77Prion diseases_Homo sapiens_hsa050200.24744196
78Renin secretion_Homo sapiens_hsa049240.23942876
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23618465
80* Glycerophospholipid metabolism_Homo sapiens_hsa005640.21612895
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21352070
82Focal adhesion_Homo sapiens_hsa045100.20443578
83One carbon pool by folate_Homo sapiens_hsa006700.19802123
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.15214509
85Arachidonic acid metabolism_Homo sapiens_hsa005900.12988022
86Type II diabetes mellitus_Homo sapiens_hsa049300.10145429
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.09991769
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.09760793
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.08178207
90Ovarian steroidogenesis_Homo sapiens_hsa049130.07396431
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.06722308
92Dilated cardiomyopathy_Homo sapiens_hsa054140.05077366
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.03397906
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.00165630
95Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.1466698
96Cardiac muscle contraction_Homo sapiens_hsa04260-0.1311426
97mTOR signaling pathway_Homo sapiens_hsa04150-0.1133006
98Amoebiasis_Homo sapiens_hsa05146-0.0982040
99Protein digestion and absorption_Homo sapiens_hsa04974-0.0973146
100Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0823403
101Circadian rhythm_Homo sapiens_hsa04710-0.0699539
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0570364
103Phospholipase D signaling pathway_Homo sapiens_hsa04072-0.0480370
104Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0465607
105FoxO signaling pathway_Homo sapiens_hsa04068-0.0452606
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412-0.0426905
107PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0414970
108TGF-beta signaling pathway_Homo sapiens_hsa04350-0.0350735
109Proteoglycans in cancer_Homo sapiens_hsa05205-0.0268005
110Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0219368
111Linoleic acid metabolism_Homo sapiens_hsa00591-0.0185842
112Adherens junction_Homo sapiens_hsa04520-0.0083417
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0040525

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