GP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.66316686
2viral transcription (GO:0019083)5.95857769
3translational termination (GO:0006415)5.71043904
4protein neddylation (GO:0045116)5.66764247
5DNA deamination (GO:0045006)5.61643347
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.18222832
7translational elongation (GO:0006414)5.18175808
8telomere maintenance via semi-conservative replication (GO:0032201)5.14968271
9DNA strand elongation involved in DNA replication (GO:0006271)5.06783669
10cotranslational protein targeting to membrane (GO:0006613)5.06673850
11protein targeting to ER (GO:0045047)5.04908362
12neutrophil activation involved in immune response (GO:0002283)4.95934023
13deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.89670969
14DNA strand elongation (GO:0022616)4.82924127
15establishment of protein localization to endoplasmic reticulum (GO:0072599)4.82746659
16protein localization to endoplasmic reticulum (GO:0070972)4.80783984
17leukocyte migration involved in inflammatory response (GO:0002523)4.63980936
18DNA replication initiation (GO:0006270)4.63366768
19ribosomal small subunit biogenesis (GO:0042274)4.59911505
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.53805090
21regulation of platelet aggregation (GO:0090330)4.53610329
22DNA unwinding involved in DNA replication (GO:0006268)4.46905735
23viral life cycle (GO:0019058)4.42519137
24heme biosynthetic process (GO:0006783)4.36773047
25neutrophil activation (GO:0042119)4.32793043
26cellular protein complex disassembly (GO:0043624)4.32718145
27purinergic nucleotide receptor signaling pathway (GO:0035590)4.28628352
28maturation of SSU-rRNA (GO:0030490)4.26389551
29translational initiation (GO:0006413)4.24782299
30response to pheromone (GO:0019236)4.22144944
31telomere maintenance via recombination (GO:0000722)4.17795198
32folic acid-containing compound biosynthetic process (GO:0009396)4.14642248
33antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.04631628
34antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.04631628
35definitive hemopoiesis (GO:0060216)4.02605753
36mitotic recombination (GO:0006312)3.90692779
37positive regulation of mast cell activation (GO:0033005)3.83826499
38protein complex disassembly (GO:0043241)3.83574411
39negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.74239200
40activated T cell proliferation (GO:0050798)3.72071113
41* regulation of platelet activation (GO:0010543)3.68436892
42protoporphyrinogen IX metabolic process (GO:0046501)3.68013713
43regulation of erythrocyte differentiation (GO:0045646)3.67962642
44granulocyte activation (GO:0036230)3.67655640
45platelet dense granule organization (GO:0060155)3.62574612
46embryonic hemopoiesis (GO:0035162)3.61762422
47heme metabolic process (GO:0042168)3.60754745
48protoporphyrinogen IX biosynthetic process (GO:0006782)3.60161641
49telomere maintenance via telomere lengthening (GO:0010833)3.59935913
50macromolecular complex disassembly (GO:0032984)3.58897312
51negative regulation of heart rate (GO:0010459)3.57291635
52negative regulation of erythrocyte differentiation (GO:0045647)3.57251688
53megakaryocyte development (GO:0035855)3.54584086
54porphyrin-containing compound biosynthetic process (GO:0006779)3.53750468
55regulation of Golgi to plasma membrane protein transport (GO:0042996)3.51177849
56antigen processing and presentation via MHC class Ib (GO:0002475)3.50266847
57regulation of MHC class II biosynthetic process (GO:0045346)3.47575711
58nuclear-transcribed mRNA catabolic process (GO:0000956)3.43618659
59negative regulation of RNA splicing (GO:0033119)3.42211106
60adenosine receptor signaling pathway (GO:0001973)3.42002116
61pteridine-containing compound biosynthetic process (GO:0042559)3.40946060
62leukocyte degranulation (GO:0043299)3.39712051
63purinergic receptor signaling pathway (GO:0035587)3.37866499
64negative regulation of cell killing (GO:0031342)3.37111391
65negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.37111391
66negative regulation of thymocyte apoptotic process (GO:0070244)3.36897123
67protein targeting to membrane (GO:0006612)3.35959765
68nucleotide-excision repair, DNA gap filling (GO:0006297)3.32714161
69negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.30357922
70negative regulation of T-helper cell differentiation (GO:0045623)3.30357922
71regulation of regulatory T cell differentiation (GO:0045589)3.29965816
72one-carbon compound transport (GO:0019755)3.28667621
73negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.28586998
74positive regulation of B cell differentiation (GO:0045579)3.27684086
75DNA replication checkpoint (GO:0000076)3.26867288
76translation (GO:0006412)3.26687560
77pseudouridine synthesis (GO:0001522)3.26286483
78mRNA catabolic process (GO:0006402)3.25902931
79CENP-A containing nucleosome assembly (GO:0034080)3.24923502
80tetrapyrrole biosynthetic process (GO:0033014)3.24850076
81G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.24564670
82erythrocyte maturation (GO:0043249)3.24205540
83ribosomal large subunit biogenesis (GO:0042273)3.22787785
84termination of G-protein coupled receptor signaling pathway (GO:0038032)3.21926586
85negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.21517146
86antigen processing and presentation of endogenous antigen (GO:0019883)3.19743330
87thrombin receptor signaling pathway (GO:0070493)3.18883336
88autophagic vacuole fusion (GO:0000046)3.18748342
89protein localization to chromosome, centromeric region (GO:0071459)3.17759626
90RNA catabolic process (GO:0006401)3.17275889
91protein localization to kinetochore (GO:0034501)3.16363853
92response to interleukin-15 (GO:0070672)3.16171452
93triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.15730651
94positive regulation of gamma-delta T cell activation (GO:0046645)3.15201448
95angiogenesis involved in wound healing (GO:0060055)3.13436691
96ribonucleoprotein complex biogenesis (GO:0022613)3.11976423
97* blood coagulation, intrinsic pathway (GO:0007597)3.11869300
98mast cell activation (GO:0045576)3.11812496
99positive regulation of endothelial cell differentiation (GO:0045603)3.10689781
100regulation of integrin-mediated signaling pathway (GO:2001044)3.07658312
101chromatin remodeling at centromere (GO:0031055)3.05954610
102termination of signal transduction (GO:0023021)3.05073746
103platelet aggregation (GO:0070527)3.04296784
104regulation of memory T cell differentiation (GO:0043380)3.03397293
105epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.03084198
106organelle membrane fusion (GO:0090174)3.01593039
107regulation of mast cell activation (GO:0033003)3.00413592
108maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.99777272
109interferon-gamma production (GO:0032609)2.99418010
110positive regulation of macrophage differentiation (GO:0045651)2.99393296
111cellular response to interleukin-15 (GO:0071350)2.95662724
112mast cell degranulation (GO:0043303)2.95373419
113mast cell activation involved in immune response (GO:0002279)2.95373419
114regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.93056559
115negative regulation of homotypic cell-cell adhesion (GO:0034111)2.92689974
116porphyrin-containing compound metabolic process (GO:0006778)2.92625040
117IMP biosynthetic process (GO:0006188)2.92352272
118oxidative phosphorylation (GO:0006119)2.91941414
119cellular response to thyroid hormone stimulus (GO:0097067)2.91924543
120erythrocyte differentiation (GO:0030218)2.91722450
121deoxyribose phosphate biosynthetic process (GO:0046385)2.91069579
1222-deoxyribonucleotide biosynthetic process (GO:0009265)2.91069579
123positive regulation of cAMP-mediated signaling (GO:0043950)2.89083349
124DNA replication-independent nucleosome organization (GO:0034724)2.88785466
125DNA replication-independent nucleosome assembly (GO:0006336)2.88785466
126antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.88152360
127response to thyroid hormone (GO:0097066)2.86512945
128positive regulation of granulocyte differentiation (GO:0030854)2.86112204
129pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.86105431
130translesion synthesis (GO:0019985)2.85409353
131formation of translation preinitiation complex (GO:0001731)2.85401978
132granulocyte differentiation (GO:0030851)2.84422522
133secretory granule organization (GO:0033363)2.84187683
134negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.83244936
135rRNA processing (GO:0006364)2.82631988
136regulation of lipoprotein metabolic process (GO:0050746)2.82374725
137L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.81965620
138purine-containing compound salvage (GO:0043101)2.81660204
139necroptotic process (GO:0070266)2.80182344
140neural tube formation (GO:0001841)2.80175448
141positive regulation of erythrocyte differentiation (GO:0045648)2.78589781
142negative regulation of appetite (GO:0032099)2.77727632
143negative regulation of response to food (GO:0032096)2.77727632
144pentose-phosphate shunt (GO:0006098)2.76873471
145natural killer cell activation involved in immune response (GO:0002323)2.76428262
146positive regulation of megakaryocyte differentiation (GO:0045654)2.75777541
147microglial cell activation (GO:0001774)2.74119753
148negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.73489097
149toxin transport (GO:1901998)2.73371867
150positive regulation of immunoglobulin mediated immune response (GO:0002891)2.73093006
151positive regulation of B cell mediated immunity (GO:0002714)2.73093006
152regulation of B cell receptor signaling pathway (GO:0050855)2.73001302
153negative regulation of norepinephrine secretion (GO:0010700)2.72331415
154superoxide anion generation (GO:0042554)2.71954574
155rRNA metabolic process (GO:0016072)2.71681763
156establishment of integrated proviral latency (GO:0075713)2.71474464
157positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.71189263
158leukocyte aggregation (GO:0070486)2.70757392
159iron-sulfur cluster assembly (GO:0016226)2.70537348
160metallo-sulfur cluster assembly (GO:0031163)2.70537348
161tyrosine phosphorylation of STAT protein (GO:0007260)2.70365881
162negative regulation of alpha-beta T cell differentiation (GO:0046639)2.68316224
163positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.68282904
164negative regulation of mRNA processing (GO:0050686)2.68077758
165telomere organization (GO:0032200)2.66775324
166regulation of integrin activation (GO:0033623)2.66379997
167regulation of macrophage derived foam cell differentiation (GO:0010743)2.65988982
168pyrimidine nucleotide catabolic process (GO:0006244)2.65159496
169regulation of homotypic cell-cell adhesion (GO:0034110)2.64869466
170behavioral response to nicotine (GO:0035095)2.62621332
171negative regulation of T cell mediated immunity (GO:0002710)2.60326434
172positive regulation of alpha-beta T cell proliferation (GO:0046641)2.57665853
173negative regulation of G-protein coupled receptor protein signaling pathway (GO:0045744)2.56724734
174negative regulation of alpha-beta T cell activation (GO:0046636)2.53640689
175negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.53450518
176amine catabolic process (GO:0009310)2.52250232
177cellular biogenic amine catabolic process (GO:0042402)2.52250232
178platelet formation (GO:0030220)2.51573558
179positive regulation of DNA recombination (GO:0045911)2.51420570
180phosphatidylinositol acyl-chain remodeling (GO:0036149)2.50949077
181low-density lipoprotein particle remodeling (GO:0034374)2.49878174
182hepatocyte apoptotic process (GO:0097284)2.49831825
183dopamine transport (GO:0015872)2.48179268
184tolerance induction (GO:0002507)2.47845692
185regulation of norepinephrine secretion (GO:0014061)2.47285652
186pyrimidine nucleoside catabolic process (GO:0046135)2.46812765
187regulation of gamma-delta T cell activation (GO:0046643)2.46403758
188regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.46383523
189regulation of natural killer cell mediated immunity (GO:0002715)2.46383523
190positive regulation of natural killer cell mediated immunity (GO:0002717)2.44233861
191regulation of endothelial cell differentiation (GO:0045601)2.43879309
192dendritic cell migration (GO:0036336)2.43380905
193dendritic cell chemotaxis (GO:0002407)2.42917922
194phospholipid homeostasis (GO:0055091)2.42884028

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.61139228
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.58281933
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.69938780
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.33701493
5SCL_19346495_ChIP-Seq_HPC-7_Human3.31469632
6EZH2_22144423_ChIP-Seq_EOC_Human3.30331580
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.04149633
8GATA1_22025678_ChIP-Seq_K562_Human2.88135613
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.71082757
10* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.68530547
11* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.67868748
12TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.66719144
13VDR_22108803_ChIP-Seq_LS180_Human2.64509223
14GBX2_23144817_ChIP-Seq_PC3_Human2.52047093
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.52000476
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.50690789
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.45749876
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.42285081
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.37400419
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.34268581
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.33537926
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.33533383
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.33202599
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.24720092
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.23368907
26RUNX_20019798_ChIP-Seq_JUKART_Human2.23022184
27IRF8_21731497_ChIP-ChIP_J774_Mouse2.22506086
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.21588512
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20524998
30IGF1R_20145208_ChIP-Seq_DFB_Human2.17369313
31XRN2_22483619_ChIP-Seq_HELA_Human2.15671596
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.14543127
33MYC_22102868_ChIP-Seq_BL_Human2.14259949
34* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.14148375
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.13954895
36MYC_19030024_ChIP-ChIP_MESCs_Mouse2.13367441
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.12157022
38VDR_23849224_ChIP-Seq_CD4+_Human1.98317004
39GATA1_22383799_ChIP-Seq_G1ME_Mouse1.97878044
40GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.96941981
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.94085809
42* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.93381218
43ERG_20887958_ChIP-Seq_HPC-7_Mouse1.90369514
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89604740
45VDR_21846776_ChIP-Seq_THP-1_Human1.87432424
46ZNF274_21170338_ChIP-Seq_K562_Hela1.81942002
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.80967690
48* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.80117620
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.79676341
50FOXP3_21729870_ChIP-Seq_TREG_Human1.78396665
51CIITA_25753668_ChIP-Seq_RAJI_Human1.74263671
52TAF15_26573619_Chip-Seq_HEK293_Human1.71861462
53GABP_19822575_ChIP-Seq_HepG2_Human1.71818758
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.70258455
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.70244459
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.68428166
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66455488
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.65941787
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65778283
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64735035
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.63559456
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61437747
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.61414067
64IRF1_19129219_ChIP-ChIP_H3396_Human1.61333781
65EWS_26573619_Chip-Seq_HEK293_Human1.61087780
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59296780
67DCP1A_22483619_ChIP-Seq_HELA_Human1.57753802
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57685685
69ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57375322
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.56752156
71CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56611133
72ER_23166858_ChIP-Seq_MCF-7_Human1.55917651
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.54863217
74AR_21909140_ChIP-Seq_LNCAP_Human1.54424226
75GATA3_26560356_Chip-Seq_TH2_Human1.54202807
76TTF2_22483619_ChIP-Seq_HELA_Human1.51929817
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51445163
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.49564844
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49337195
80EGR1_19374776_ChIP-ChIP_THP-1_Human1.44328654
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.43079994
82GATA2_19941826_ChIP-Seq_K562_Human1.40622542
83* SPI1_23547873_ChIP-Seq_NB4_Human1.40096879
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.39519868
85RUNX1_22412390_ChIP-Seq_EML_Mouse1.39205457
86P300_19829295_ChIP-Seq_ESCs_Human1.38712327
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34344220
88IRF8_27001747_Chip-Seq_BMDM_Mouse1.33248883
89GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32755021
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32084999
91BCAT_22108803_ChIP-Seq_LS180_Human1.31178026
92CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29304936
93IRF8_22096565_ChIP-ChIP_GC-B_Human1.29147979
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28511922
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.28243895
96ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28175174
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27859238
98YY1_21170310_ChIP-Seq_MESCs_Mouse1.26270426
99HTT_18923047_ChIP-ChIP_STHdh_Human1.26250050
100SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25560388
101MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25190873
102FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24763257
103ELK1_19687146_ChIP-ChIP_HELA_Human1.23925559
104MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.23422247
105* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23386614
106ELK4_26923725_Chip-Seq_MESODERM_Mouse1.22861849
107STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22746892
108IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22345220
109GATA3_21878914_ChIP-Seq_MCF-7_Human1.21593539
110E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21397383
111GATA3_27048872_Chip-Seq_THYMUS_Human1.20730413
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.20650090
113* AR_25329375_ChIP-Seq_VCAP_Human1.19386215
114VDR_24763502_ChIP-Seq_THP-1_Human1.19045287
115MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18188483
116GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17857264
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16636313
118SPI1_23127762_ChIP-Seq_K562_Human1.16529986
119SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16410567
120SMAD4_21799915_ChIP-Seq_A2780_Human1.16333978
121PIAS1_25552417_ChIP-Seq_VCAP_Human1.16318143
122CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16146564
123MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13777773
124TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12288791
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12288791
126NANOG_19829295_ChIP-Seq_ESCs_Human1.11853660
127SOX2_19829295_ChIP-Seq_ESCs_Human1.11853660
128CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10882507
129AR_21572438_ChIP-Seq_LNCaP_Human1.10797418
130CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.10536386
131* FOXA1_25329375_ChIP-Seq_VCAP_Human1.09709459
132* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09709459
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09568540
134P53_22387025_ChIP-Seq_ESCs_Mouse1.09139362
135GATA2_21666600_ChIP-Seq_HMVEC_Human1.08902828
136PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08088224
137PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08050686
138Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07683471
139PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06843084
140MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06511206
141STAT3_23295773_ChIP-Seq_U87_Human1.06423894
142PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.05836061
143ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.05750848
144UTX_26944678_Chip-Seq_JUKART_Human1.05705152
145MAF_26560356_Chip-Seq_TH1_Human1.05154093
146TCF4_23295773_ChIP-Seq_U87_Human1.04306723
147RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04227605
148STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03823742
149KDM5A_27292631_Chip-Seq_BREAST_Human1.03274569
150TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02833280
151TP53_22573176_ChIP-Seq_HFKS_Human1.02804599
152CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02762023
153SMRT_27268052_Chip-Seq_Bcells_Human1.02630562
154PRDM14_20953172_ChIP-Seq_ESCs_Human1.02292474
155* TCF7_22412390_ChIP-Seq_EML_Mouse1.02130559
156MYB_26560356_Chip-Seq_TH2_Human1.01746946
157TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01595438
158PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01523762
159OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00899914
160CRX_20693478_ChIP-Seq_RETINA_Mouse0.99912297
161SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99737975
162FLI1_21867929_ChIP-Seq_TH2_Mouse0.99456436
163* AR_20517297_ChIP-Seq_VCAP_Human0.99407259
164* MYB_26560356_Chip-Seq_TH1_Human0.99381935
165CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99320187
166* SALL4_22934838_ChIP-ChIP_CD34+_Human0.98871123
167CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98796536
168CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97697322
169ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96825238
170* NANOG_20526341_ChIP-Seq_ESCs_Human0.96655804
171KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.96640015
172BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96535144
173CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96158018
174PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95651692
175YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95497584
176MYC_18940864_ChIP-ChIP_HL60_Human0.95370647
177ERG_20517297_ChIP-Seq_VCAP_Human0.94886446
178FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94616846
179DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94405782
180EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94219344
181GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.94007988
182OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93868773
183STAT4_19710469_ChIP-ChIP_TH1__Mouse0.93364434
184TFEB_21752829_ChIP-Seq_HELA_Human0.90618783
185CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90567883
186GATA1_19941826_ChIP-Seq_K562_Human0.90550347

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level5.24704138
2MP0003656_abnormal_erythrocyte_physiolo4.70061609
3MP0002396_abnormal_hematopoietic_system4.40405628
4MP0005397_hematopoietic_system_phenotyp3.69444263
5MP0001545_abnormal_hematopoietic_system3.69444263
6MP0006054_spinal_hemorrhage3.64319385
7MP0000465_gastrointestinal_hemorrhage3.54168919
8MP0005464_abnormal_platelet_physiology3.16504808
9MP0003693_abnormal_embryo_hatching3.01619411
10MP0004808_abnormal_hematopoietic_stem2.88485917
11MP0010094_abnormal_chromosome_stability2.83631651
12MP0008004_abnormal_stomach_pH2.75258751
13MP0003111_abnormal_nucleus_morphology2.70374685
14MP0005174_abnormal_tail_pigmentation2.39943498
15MP0008057_abnormal_DNA_replication2.39118342
16MP0004957_abnormal_blastocyst_morpholog2.36849153
17MP0000490_abnormal_crypts_of2.35742763
18MP0003303_peritoneal_inflammation2.24649798
19MP0005075_abnormal_melanosome_morpholog2.16037652
20MP0003077_abnormal_cell_cycle2.08770791
21MP0002398_abnormal_bone_marrow2.05150647
22MP0005084_abnormal_gallbladder_morpholo2.02998258
23MP0008877_abnormal_DNA_methylation2.01947940
24MP0003806_abnormal_nucleotide_metabolis1.99091928
25MP0005646_abnormal_pituitary_gland1.98491663
26MP0002877_abnormal_melanocyte_morpholog1.97696981
27MP0000230_abnormal_systemic_arterial1.92518998
28MP0002139_abnormal_hepatobiliary_system1.84382831
29MP0002132_abnormal_respiratory_system1.82118960
30MP0006036_abnormal_mitochondrial_physio1.73865906
31MP0002148_abnormal_hypersensitivity_rea1.70541018
32MP0000689_abnormal_spleen_morphology1.69513471
33MP0009333_abnormal_splenocyte_physiolog1.68258935
34MP0002722_abnormal_immune_system1.67761217
35MP0004130_abnormal_muscle_cell1.67645811
36MP0005671_abnormal_response_to1.65419078
37MP0008007_abnormal_cellular_replicative1.65084691
38MP0003186_abnormal_redox_activity1.63811103
39MP0004510_myositis1.63324689
40MP0003724_increased_susceptibility_to1.60924667
41MP0001835_abnormal_antigen_presentation1.60589881
42MP0002429_abnormal_blood_cell1.55280192
43MP0001986_abnormal_taste_sensitivity1.53862118
44MP0002095_abnormal_skin_pigmentation1.49645632
45MP0002736_abnormal_nociception_after1.45512056
46MP0005167_abnormal_blood-brain_barrier1.45397584
47MP0001790_abnormal_immune_system1.44963502
48MP0005387_immune_system_phenotype1.44963502
49MP0005083_abnormal_biliary_tract1.44951317
50MP0005645_abnormal_hypothalamus_physiol1.43431661
51MP0008995_early_reproductive_senescence1.43400621
52MP0003763_abnormal_thymus_physiology1.42523169
53MP0008058_abnormal_DNA_repair1.41796065
54MP0002653_abnormal_ependyma_morphology1.40845376
55MP0001853_heart_inflammation1.38295563
56MP0005410_abnormal_fertilization1.35148835
57MP0003638_abnormal_response/metabolism_1.31912843
58MP0000313_abnormal_cell_death1.31667927
59MP0001533_abnormal_skeleton_physiology1.31426687
60MP0009379_abnormal_foot_pigmentation1.29824405
61MP0003011_delayed_dark_adaptation1.29627501
62MP0000716_abnormal_immune_system1.28327197
63MP0002019_abnormal_tumor_incidence1.26731255
64MP0002638_abnormal_pupillary_reflex1.26241441
65MP0001968_abnormal_touch/_nociception1.25683802
66MP0003787_abnormal_imprinting1.25032632
67MP0003136_yellow_coat_color1.20657333
68MP0000703_abnormal_thymus_morphology1.20416591
69MP0000685_abnormal_immune_system1.18973564
70MP0001501_abnormal_sleep_pattern1.17437544
71MP0002733_abnormal_thermal_nociception1.16114721
72MP0005636_abnormal_mineral_homeostasis1.13225536
73MP0002138_abnormal_hepatobiliary_system1.11970399
74MP0004084_abnormal_cardiac_muscle1.11842254
75MP0002420_abnormal_adaptive_immunity1.11120640
76MP0008932_abnormal_embryonic_tissue1.10674564
77MP0001800_abnormal_humoral_immune1.09544087
78MP0001765_abnormal_ion_homeostasis1.09123235
79MP0002876_abnormal_thyroid_physiology1.08396860
80MP0001819_abnormal_immune_cell1.08127377
81MP0005025_abnormal_response_to1.07332125
82MP0009840_abnormal_foam_cell1.06912141
83MP0001851_eye_inflammation1.06220860
84MP0002723_abnormal_immune_serum1.05905973
85MP0000569_abnormal_digit_pigmentation1.05619101
86MP0001188_hyperpigmentation1.05066435
87MP0010155_abnormal_intestine_physiology1.04555207
88MP0000343_altered_response_to1.03959015
89MP0003828_pulmonary_edema1.03411476
90MP0004133_heterotaxia1.03302590
91MP0009278_abnormal_bone_marrow1.03295224
92MP0010352_gastrointestinal_tract_polyps1.02761762
93MP0009785_altered_susceptibility_to1.01720378
94MP0002166_altered_tumor_susceptibility1.01511008
95MP0006276_abnormal_autonomic_nervous1.00602892
96MP0005551_abnormal_eye_electrophysiolog1.00515642
97MP0003866_abnormal_defecation0.99766695
98MP0003172_abnormal_lysosome_physiology0.99688993
99MP0005000_abnormal_immune_tolerance0.99535295
100MP0008469_abnormal_protein_level0.98600582
101MP0000249_abnormal_blood_vessel0.97783012
102MP0009763_increased_sensitivity_to0.97220789
103MP0002452_abnormal_antigen_presenting0.96659442
104MP0000015_abnormal_ear_pigmentation0.96414610
105MP0004142_abnormal_muscle_tone0.94968290
106MP0001970_abnormal_pain_threshold0.93930910
107MP0000350_abnormal_cell_proliferation0.92656039
108MP0003300_gastrointestinal_ulcer0.92153773
109MP0003879_abnormal_hair_cell0.90059755
110MP0001879_abnormal_lymphatic_vessel0.89842746
111MP0008875_abnormal_xenobiotic_pharmacok0.89121778
112MP0001485_abnormal_pinna_reflex0.87174750
113MP0005535_abnormal_body_temperature0.86757975
114MP0004947_skin_inflammation0.86100634
115MP0002405_respiratory_system_inflammati0.86001697
116MP0008961_abnormal_basal_metabolism0.85878617
117MP0006035_abnormal_mitochondrial_morpho0.85602212
118MP0003195_calcinosis0.83666091
119MP0003868_abnormal_feces_composition0.83625510
120MP0000598_abnormal_liver_morphology0.82555551
121MP0005319_abnormal_enzyme/_coenzyme0.82312629
122MP0002102_abnormal_ear_morphology0.82212198
123MP0003566_abnormal_cell_adhesion0.81893535
124MP0009765_abnormal_xenobiotic_induced0.81439243
125MP0001845_abnormal_inflammatory_respons0.81270355
126MP0009745_abnormal_behavioral_response0.81023513
127MP0002419_abnormal_innate_immunity0.80355994
128MP0000358_abnormal_cell_content/0.80236549
129MP0008872_abnormal_physiological_respon0.79605115
130MP0002080_prenatal_lethality0.79323476
131MP0005584_abnormal_enzyme/coenzyme_acti0.79224983
132MP0004484_altered_response_of0.78350783
133MP0001915_intracranial_hemorrhage0.77846481
134MP0003943_abnormal_hepatobiliary_system0.77688887
135MP0004215_abnormal_myocardial_fiber0.76554758
136MP0000609_abnormal_liver_physiology0.75580988
137MP0002693_abnormal_pancreas_physiology0.75395658
138MP0003191_abnormal_cellular_cholesterol0.74704873
139MP0003878_abnormal_ear_physiology0.74536545
140MP0005377_hearing/vestibular/ear_phenot0.74536545
141* MP0009642_abnormal_blood_homeostasis0.74365529
142MP0003221_abnormal_cardiomyocyte_apopto0.74313907
143MP0001919_abnormal_reproductive_system0.73989956
144MP0001764_abnormal_homeostasis0.70586189
145MP0003436_decreased_susceptibility_to0.69789413
146MP0001730_embryonic_growth_arrest0.69319343
147MP0001873_stomach_inflammation0.68828352
148MP0000477_abnormal_intestine_morphology0.67909056
149MP0005365_abnormal_bile_salt0.67688346
150MP0002089_abnormal_postnatal_growth/wei0.67569347
151MP0008775_abnormal_heart_ventricle0.67483696
152MP0002006_tumorigenesis0.66405664
153MP0001663_abnormal_digestive_system0.65603386
154MP0010329_abnormal_lipoprotein_level0.65500133
155MP0009764_decreased_sensitivity_to0.64272773
156MP0005085_abnormal_gallbladder_physiolo0.64139277
157MP0010307_abnormal_tumor_latency0.63098475

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)8.21230574
2Petechiae (HP:0000967)7.77744429
3Abnormal number of erythroid precursors (HP:0012131)7.51906523
4Abnormality of cells of the erythroid lineage (HP:0012130)7.25546066
5Prolonged bleeding time (HP:0003010)7.06012165
6Purpura (HP:0000979)5.96479398
7Abnormal platelet volume (HP:0011876)5.32585174
8Increased mean platelet volume (HP:0011877)5.29533875
9Menorrhagia (HP:0000132)4.83864941
10Aplastic anemia (HP:0001915)4.76478563
11Impaired platelet aggregation (HP:0003540)4.58709121
12Abnormal platelet function (HP:0011869)4.58709121
13Stomatitis (HP:0010280)4.53662599
14Epistaxis (HP:0000421)4.34559952
15Hyperlipoproteinemia (HP:0010980)4.28316203
16Chronic otitis media (HP:0000389)4.24166192
17Pallor (HP:0000980)4.17314971
18Reticulocytopenia (HP:0001896)4.03389283
19Acanthocytosis (HP:0001927)3.96644652
20Poikilocytosis (HP:0004447)3.65476549
21Gingival bleeding (HP:0000225)3.33506836
22Abnormality of reticulocytes (HP:0004312)3.30564920
23Macrocytic anemia (HP:0001972)3.28664659
24IgM deficiency (HP:0002850)3.23807104
25Reduced antithrombin III activity (HP:0001976)3.18877538
26Increased serum ferritin (HP:0003281)3.17998025
27Spontaneous hematomas (HP:0007420)3.14450362
28Reticulocytosis (HP:0001923)2.89601215
29Congenital stationary night blindness (HP:0007642)2.89143451
30Type I transferrin isoform profile (HP:0003642)2.83447405
31Hyperbilirubinemia (HP:0002904)2.78231776
32Esophageal neoplasm (HP:0100751)2.66843693
33Neoplasm of head and neck (HP:0012288)2.66843693
34Pancreatic cysts (HP:0001737)2.66640392
35Dynein arm defect of respiratory motile cilia (HP:0012255)2.66587642
36Absent/shortened dynein arms (HP:0200106)2.66587642
37Hepatocellular necrosis (HP:0001404)2.65454366
38Abnormality of iron homeostasis (HP:0011031)2.61088167
39Elevated erythrocyte sedimentation rate (HP:0003565)2.60732913
40Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.59876068
41Decreased activity of mitochondrial respiratory chain (HP:0008972)2.59876068
42Abnormal respiratory motile cilium morphology (HP:0005938)2.54669279
43Abnormal respiratory epithelium morphology (HP:0012253)2.54669279
44Oral leukoplakia (HP:0002745)2.54437557
45Molar tooth sign on MRI (HP:0002419)2.53935035
46Abnormality of midbrain morphology (HP:0002418)2.53935035
47Pancytopenia (HP:0001876)2.53743272
48Conjunctival telangiectasia (HP:0000524)2.53537549
49Microvesicular hepatic steatosis (HP:0001414)2.50062431
50Dyschromatopsia (HP:0007641)2.47469037
51Birth length less than 3rd percentile (HP:0003561)2.47120864
52Abnormal ciliary motility (HP:0012262)2.44490497
53Cerebellar dysplasia (HP:0007033)2.43788785
54Hepatic necrosis (HP:0002605)2.42537419
55Increased density of long bones (HP:0006392)2.39848701
56Pancreatic fibrosis (HP:0100732)2.39558152
57Abnormal protein glycosylation (HP:0012346)2.39005312
58Abnormal glycosylation (HP:0012345)2.39005312
59Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.39005312
60Abnormal protein N-linked glycosylation (HP:0012347)2.39005312
61True hermaphroditism (HP:0010459)2.37848428
62Thrombocytosis (HP:0001894)2.37246650
63Abnormality of lateral ventricle (HP:0030047)2.36452819
64Abnormality of transition element cation homeostasis (HP:0011030)2.34224210
65Panhypogammaglobulinemia (HP:0003139)2.32987366
66Decreased central vision (HP:0007663)2.31883011
67Microcytic anemia (HP:0001935)2.29969478
68Papilledema (HP:0001085)2.29759096
69Increased intramyocellular lipid droplets (HP:0012240)2.29459994
70Attenuation of retinal blood vessels (HP:0007843)2.27571559
71Bruising susceptibility (HP:0000978)2.26609806
72Encephalitis (HP:0002383)2.25195633
73Retrobulbar optic neuritis (HP:0100654)2.24124861
74Optic neuritis (HP:0100653)2.24124861
75Congenital, generalized hypertrichosis (HP:0004540)2.22196315
76Thyroid-stimulating hormone excess (HP:0002925)2.21702849
77Recurrent viral infections (HP:0004429)2.18904085
78Muscle fiber atrophy (HP:0100295)2.18893293
79Abnormal spermatogenesis (HP:0008669)2.17987913
80Nephronophthisis (HP:0000090)2.16889505
81Increased serum lactate (HP:0002151)2.15799994
82Abnormality of the vasculature of the conjunctiva (HP:0008054)2.12894798
83Eczematoid dermatitis (HP:0000976)2.12464141
84Nasal polyposis (HP:0100582)2.12235563
85Abnormality of the nasal mucosa (HP:0000433)2.12134732
86T lymphocytopenia (HP:0005403)2.11025500
87Clumsiness (HP:0002312)2.09347962
88Hypochromic microcytic anemia (HP:0004840)2.09063122
89Abnormality of T cell number (HP:0011839)2.07139207
90Hypoplasia of the thymus (HP:0000778)2.06797205
91Increased IgM level (HP:0003496)2.06633404
92Progressive muscle weakness (HP:0003323)2.04969257
93Progressive cerebellar ataxia (HP:0002073)2.03612551
94Mitochondrial inheritance (HP:0001427)2.03390390
95Increased muscle lipid content (HP:0009058)2.03138140
96IgG deficiency (HP:0004315)2.03036801
97Abnormality of the renal cortex (HP:0011035)1.98941432
98Myelodysplasia (HP:0002863)1.98571872
99Type 2 muscle fiber atrophy (HP:0003554)1.97168120
100Hemiparesis (HP:0001269)1.96803430
101Abolished electroretinogram (ERG) (HP:0000550)1.96569941
102Increased hepatocellular lipid droplets (HP:0006565)1.96037498
103Agitation (HP:0000713)1.96035815
104Paralysis (HP:0003470)1.95493965
105Cholecystitis (HP:0001082)1.95127716
106Abnormal gallbladder physiology (HP:0012438)1.95127716
107Neoplasm of the rectum (HP:0100743)1.93698453
108Abnormality of the prostate (HP:0008775)1.93496311
109Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93418966
110Recurrent fungal infections (HP:0002841)1.92334082
111Leukocytosis (HP:0001974)1.92209456
112Abnormal rod and cone electroretinograms (HP:0008323)1.91421187
113Abnormality of T cell physiology (HP:0011840)1.91248794
114Myositis (HP:0100614)1.90633590
115Neutropenia (HP:0001875)1.90601786
116Acute lymphatic leukemia (HP:0006721)1.90600496
117Hyperventilation (HP:0002883)1.88167005
118Selective tooth agenesis (HP:0001592)1.88134244
119Increased CSF lactate (HP:0002490)1.88033202
120Arterial thrombosis (HP:0004420)1.87168128
121Joint swelling (HP:0001386)1.86973134
122Abnormal pupillary function (HP:0007686)1.85914317
123Brushfield spots (HP:0001088)1.85292457
124Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84660040
125Lipid accumulation in hepatocytes (HP:0006561)1.84547690
126Polycythemia (HP:0001901)1.84446925
12711 pairs of ribs (HP:0000878)1.83721655
128Stomach cancer (HP:0012126)1.82669081
129Abnormality of T cells (HP:0002843)1.82504766
130Febrile seizures (HP:0002373)1.82237266
131Optic nerve hypoplasia (HP:0000609)1.82065529
132Abnormality of the renal medulla (HP:0100957)1.81577392
133Lymphoma (HP:0002665)1.81490983
134Cystic liver disease (HP:0006706)1.81435168
135Lactic acidosis (HP:0003128)1.80935676
136Recurrent bronchitis (HP:0002837)1.80900472
137Abnormal respiratory motile cilium physiology (HP:0012261)1.79480893
138Polydipsia (HP:0001959)1.79457280
139Abnormal drinking behavior (HP:0030082)1.79457280
140Hypochromic anemia (HP:0001931)1.78879294
141Recurrent abscess formation (HP:0002722)1.78300048
142Ventricular fibrillation (HP:0001663)1.77509392
143Abnormal delayed hypersensitivity skin test (HP:0002963)1.76638329
144Squamous cell carcinoma (HP:0002860)1.76421044
145Arthropathy (HP:0003040)1.75566069
146Chronic obstructive pulmonary disease (HP:0006510)1.75496970
147Obstructive lung disease (HP:0006536)1.75496970
148Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.75414328
149Orchitis (HP:0100796)1.74869206
150Neoplasm of the small intestine (HP:0100833)1.74273775
151Abnormality of the common coagulation pathway (HP:0010990)1.74159129
152Vertigo (HP:0002321)1.72906082
153Episodic fever (HP:0001954)1.72717123
154Abnormality of eosinophils (HP:0001879)1.70863772
155Azoospermia (HP:0000027)1.70535736
156Cellulitis (HP:0100658)1.69646666
157Microretrognathia (HP:0000308)1.69623273
158Exertional dyspnea (HP:0002875)1.67706823
159Respiratory difficulties (HP:0002880)1.67329688
160Migraine (HP:0002076)1.66183275
161Tinnitus (HP:0000360)1.65438750
162Slender long bone (HP:0003100)1.65021899
1633-Methylglutaconic aciduria (HP:0003535)1.64852009
164Cutaneous photosensitivity (HP:0000992)1.64254455
165Short middle phalanx of the 5th finger (HP:0004220)1.63472090
166Acute myeloid leukemia (HP:0004808)1.63405307
167Abnormal mitochondria in muscle tissue (HP:0008316)1.63404172
168Hypoplasia of the pons (HP:0012110)1.62883001
169Agammaglobulinemia (HP:0004432)1.61663763
170Colon cancer (HP:0003003)1.61615243
171Bone marrow hypocellularity (HP:0005528)1.61005496
172Poikiloderma (HP:0001029)1.60150303
173Basal cell carcinoma (HP:0002671)1.60126355
174Autoimmune hemolytic anemia (HP:0001890)1.59507144
175Abnormality of macrophages (HP:0004311)1.57387733
176Keratoconjunctivitis (HP:0001096)1.56677680
177Renal cortical cysts (HP:0000803)1.53143123
178Gastrointestinal infarctions (HP:0005244)1.51609097

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.35251123
2NME23.75284283
3RIPK43.60284733
4TXK3.31241588
5MST43.11120436
6FRK2.99078606
7WEE12.99047198
8TNIK2.98647538
9PIM22.69301654
10CDC72.58180245
11KIT2.57323655
12CDK192.48708764
13VRK12.44245429
14INSRR2.37398065
15EEF2K2.37106538
16ADRBK22.30275780
17DYRK32.25578913
18PNCK2.23753364
19MATK2.18049366
20PTK2B2.17496569
21TIE12.01692102
22BUB11.87205050
23SCYL21.84908779
24NEK21.81413743
25EIF2AK11.76784417
26MAPKAPK51.76559896
27KDR1.75917414
28BMX1.72426850
29TAOK31.70822989
30EPHA31.70588909
31BMPR1B1.70441751
32TEC1.68040604
33BTK1.65816592
34RPS6KB21.65106492
35GRK11.63474795
36BRSK21.57073403
37STK31.46342850
38CCNB11.42172699
39ACVR1B1.41741164
40STK391.40578993
41NUAK11.40363967
42MAP4K11.38551538
43TTK1.38317931
44WNK41.36772131
45LRRK21.36718021
46IRAK11.36451935
47MAP2K31.34521929
48HCK1.32283641
49DAPK21.28713182
50PASK1.27944059
51SRPK11.27057004
52FLT31.23926008
53TGFBR11.22842690
54PAK31.21377327
55ITK1.20661840
56CDK41.16289853
57CDK71.15527381
58BCKDK1.14581429
59MAP3K61.12850789
60MUSK1.12559785
61CAMKK21.12505448
62TYK21.11660053
63MAP3K111.09439694
64MAP3K101.09113216
65BRSK11.08097244
66NEK11.07556799
67MKNK11.06756316
68ATR1.06225689
69MYLK1.06176769
70PIK3CG1.04300409
71NLK1.03135180
72TNK21.02287623
73TLK11.01579810
74TBK11.00954853
75ZAK0.96840213
76MARK30.95761365
77RPS6KA40.95730565
78WNK30.95485576
79ZAP700.94947652
80PIM10.90781473
81ADRBK10.90389108
82SYK0.89793258
83RAF10.89223685
84FGR0.87252060
85MAPKAPK30.87069896
86JAK30.86756897
87PKN20.86167731
88IRAK40.84752140
89SGK20.84572453
90EIF2AK30.84307233
91CSK0.83939842
92GRK50.83027842
93STK100.82939156
94BLK0.82811629
95MAP3K120.82628147
96STK40.82195634
97OXSR10.81776448
98AURKB0.81716534
99MAPK130.80699845
100BMPR20.80313465
101CASK0.79055724
102STK240.76137470
103LYN0.74959504
104PLK10.73260381
105PRKCQ0.71485610
106EPHB10.71389483
107MAP3K80.71030383
108IKBKE0.68929403
109TRIM280.68644897
110DAPK10.68288196
111JAK10.66574284
112MAP2K10.65251824
113MAP2K70.64578592
114CLK10.64030707
115GRK60.63985677
116CDK80.63380364
117TGFBR20.60517891
118JAK20.60351636
119MAPK150.57880747
120YES10.57502631
121PKN10.57297119
122NEK90.56251494
123FER0.54973503
124MAPK110.54895450
125MKNK20.52266532
126SIK30.52017533
127HIPK20.51475881
128IKBKB0.50629587
129PLK20.50229917
130MAP2K60.50125347
131NME10.49509150
132MAP4K20.49103464
133ERN10.48770412
134CDK60.48733033
135ERBB20.47725917
136PRKCG0.45870009
137MAP3K70.45655087
138PAK40.45502513
139CHEK10.45414317
140MAP2K20.45362581
141MAPK40.44045074
142CSNK2A20.43774268
143CSF1R0.42803336
144CAMK10.42726108
145TESK20.42562473
146SGK30.42278988
147PDK10.42182948
148FES0.40995406
149BRD40.40727780
150PAK20.40568065
151PINK10.38111911
152TAOK10.35861780
153MAP3K50.34401325
154ILK0.34112305
155PLK30.34030666
156ABL20.33401531
157PRKCE0.33330063
158AURKA0.33092725
159DYRK20.33027820
160PDGFRB0.32142477
161PRKG10.31936124
162LCK0.31362027
163SGK4940.31338171
164SGK2230.31338171
165CSNK2A10.31314082
166PRKACG0.30798343
167MAPK120.30719633
168CHEK20.30672663

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.87997320
2Ribosome_Homo sapiens_hsa030105.12543158
3Mismatch repair_Homo sapiens_hsa034304.07454380
4Nitrogen metabolism_Homo sapiens_hsa009102.91762724
5Base excision repair_Homo sapiens_hsa034102.84104966
6Homologous recombination_Homo sapiens_hsa034402.83331009
7Pyrimidine metabolism_Homo sapiens_hsa002402.60795277
8Spliceosome_Homo sapiens_hsa030402.56838165
9Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.48102888
10RNA polymerase_Homo sapiens_hsa030202.40040959
11Nucleotide excision repair_Homo sapiens_hsa034202.36997455
12One carbon pool by folate_Homo sapiens_hsa006702.29570967
13Linoleic acid metabolism_Homo sapiens_hsa005912.28513920
14Sulfur relay system_Homo sapiens_hsa041222.24967641
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.17500902
16Phototransduction_Homo sapiens_hsa047442.14958875
17Cell cycle_Homo sapiens_hsa041102.06292669
18Proteasome_Homo sapiens_hsa030502.02002325
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.93504364
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.88231430
21Folate biosynthesis_Homo sapiens_hsa007901.86000435
22Arachidonic acid metabolism_Homo sapiens_hsa005901.82203769
23Chemokine signaling pathway_Homo sapiens_hsa040621.70850277
24* Hematopoietic cell lineage_Homo sapiens_hsa046401.69742936
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.69092379
26T cell receptor signaling pathway_Homo sapiens_hsa046601.64311563
27RNA transport_Homo sapiens_hsa030131.59251963
28Protein export_Homo sapiens_hsa030601.58048541
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57536859
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.53233098
31Pentose phosphate pathway_Homo sapiens_hsa000301.50670851
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.50090878
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45660436
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.45480611
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.45076925
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.44946292
37Serotonergic synapse_Homo sapiens_hsa047261.43936343
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.42639560
39Fanconi anemia pathway_Homo sapiens_hsa034601.40943214
40N-Glycan biosynthesis_Homo sapiens_hsa005101.38497271
41Collecting duct acid secretion_Homo sapiens_hsa049661.34950664
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.34705265
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.33907250
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31114554
45Olfactory transduction_Homo sapiens_hsa047401.30331310
46Purine metabolism_Homo sapiens_hsa002301.29364609
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.27628441
48Parkinsons disease_Homo sapiens_hsa050121.27319387
49Morphine addiction_Homo sapiens_hsa050321.24844564
50Non-homologous end-joining_Homo sapiens_hsa034501.23782559
51Malaria_Homo sapiens_hsa051441.23669656
52Circadian entrainment_Homo sapiens_hsa047131.23036881
53Ether lipid metabolism_Homo sapiens_hsa005651.15950549
54p53 signaling pathway_Homo sapiens_hsa041151.15610715
55* Platelet activation_Homo sapiens_hsa046111.13556414
56Herpes simplex infection_Homo sapiens_hsa051681.12232653
57Selenocompound metabolism_Homo sapiens_hsa004501.11743641
58RNA degradation_Homo sapiens_hsa030181.11242986
59Glycerolipid metabolism_Homo sapiens_hsa005611.10483656
60Osteoclast differentiation_Homo sapiens_hsa043801.09428556
61Antigen processing and presentation_Homo sapiens_hsa046121.07688677
62Allograft rejection_Homo sapiens_hsa053301.05056908
63Autoimmune thyroid disease_Homo sapiens_hsa053200.93811162
64Acute myeloid leukemia_Homo sapiens_hsa052210.93118512
65Type I diabetes mellitus_Homo sapiens_hsa049400.90463832
66Graft-versus-host disease_Homo sapiens_hsa053320.90320092
67Long-term depression_Homo sapiens_hsa047300.89035446
68Primary immunodeficiency_Homo sapiens_hsa053400.88358963
69Regulation of autophagy_Homo sapiens_hsa041400.87699955
70Systemic lupus erythematosus_Homo sapiens_hsa053220.86020198
71GABAergic synapse_Homo sapiens_hsa047270.84156655
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82970929
73Small cell lung cancer_Homo sapiens_hsa052220.82101069
74Dorso-ventral axis formation_Homo sapiens_hsa043200.81400075
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79934225
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78972919
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78549842
78Calcium signaling pathway_Homo sapiens_hsa040200.77807500
79Oxidative phosphorylation_Homo sapiens_hsa001900.76891255
80Gap junction_Homo sapiens_hsa045400.74276339
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.73456519
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73446279
83Huntingtons disease_Homo sapiens_hsa050160.72811377
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71972865
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70639538
86Biosynthesis of amino acids_Homo sapiens_hsa012300.70082246
87Caffeine metabolism_Homo sapiens_hsa002320.69778678
88Chemical carcinogenesis_Homo sapiens_hsa052040.69090313
89ABC transporters_Homo sapiens_hsa020100.69004259
90Pancreatic secretion_Homo sapiens_hsa049720.67891121
91Staphylococcus aureus infection_Homo sapiens_hsa051500.67529147
92Cholinergic synapse_Homo sapiens_hsa047250.67223402
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67218316
94Chronic myeloid leukemia_Homo sapiens_hsa052200.65005453
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.64966074
96Hepatitis B_Homo sapiens_hsa051610.64626190
97Basal transcription factors_Homo sapiens_hsa030220.64229595
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63766694
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63387489
100Apoptosis_Homo sapiens_hsa042100.63268550
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.62486225
102Legionellosis_Homo sapiens_hsa051340.60864329
103Epstein-Barr virus infection_Homo sapiens_hsa051690.60299401
104Glutamatergic synapse_Homo sapiens_hsa047240.60048060
105Measles_Homo sapiens_hsa051620.59976428
106Viral carcinogenesis_Homo sapiens_hsa052030.59738679
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59711289
108Ras signaling pathway_Homo sapiens_hsa040140.59129092
109Ovarian steroidogenesis_Homo sapiens_hsa049130.58804057
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.58006874
111Butanoate metabolism_Homo sapiens_hsa006500.57482475
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57475261
113Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57113573
114Carbon metabolism_Homo sapiens_hsa012000.56930059
115Thyroid cancer_Homo sapiens_hsa052160.56062712
116B cell receptor signaling pathway_Homo sapiens_hsa046620.54539361
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53495732
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.53002316
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.52707786
120Phagosome_Homo sapiens_hsa041450.52486605
121Renin secretion_Homo sapiens_hsa049240.51750092
122Fat digestion and absorption_Homo sapiens_hsa049750.50549862
123Alzheimers disease_Homo sapiens_hsa050100.50431263
124Oxytocin signaling pathway_Homo sapiens_hsa049210.50399434
125Salivary secretion_Homo sapiens_hsa049700.49981934
126FoxO signaling pathway_Homo sapiens_hsa040680.49370467
127Rap1 signaling pathway_Homo sapiens_hsa040150.48152313
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47882290
129African trypanosomiasis_Homo sapiens_hsa051430.46980123
1302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46962514
131Tuberculosis_Homo sapiens_hsa051520.45409203
132Rheumatoid arthritis_Homo sapiens_hsa053230.44261879
133Endocytosis_Homo sapiens_hsa041440.44143107
134Galactose metabolism_Homo sapiens_hsa000520.43601303
135Leukocyte transendothelial migration_Homo sapiens_hsa046700.43536974
136Shigellosis_Homo sapiens_hsa051310.43451489
137Fatty acid biosynthesis_Homo sapiens_hsa000610.43023400
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42882525
139Metabolic pathways_Homo sapiens_hsa011000.42644378
140Leishmaniasis_Homo sapiens_hsa051400.41018884
141Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40981223
142mRNA surveillance pathway_Homo sapiens_hsa030150.39121623
143Circadian rhythm_Homo sapiens_hsa047100.38147453
144Pyruvate metabolism_Homo sapiens_hsa006200.38063581
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37992574
146Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37811403
147Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37025386
148TNF signaling pathway_Homo sapiens_hsa046680.36797705
149Gastric acid secretion_Homo sapiens_hsa049710.36569924
150* ECM-receptor interaction_Homo sapiens_hsa045120.36393128
151Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34497605
152Alcoholism_Homo sapiens_hsa050340.33189893
153Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31936760
154Toxoplasmosis_Homo sapiens_hsa051450.31730371
155NF-kappa B signaling pathway_Homo sapiens_hsa040640.30850199
156Colorectal cancer_Homo sapiens_hsa052100.28793548
157Other glycan degradation_Homo sapiens_hsa005110.26998799
158Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26580698
159Jak-STAT signaling pathway_Homo sapiens_hsa046300.25963138
160Non-small cell lung cancer_Homo sapiens_hsa052230.25135170
161HTLV-I infection_Homo sapiens_hsa051660.23591566
162Influenza A_Homo sapiens_hsa051640.23460950
163Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.22318742
164Glutathione metabolism_Homo sapiens_hsa004800.21978401
165Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.20200453
166Oocyte meiosis_Homo sapiens_hsa041140.19629917
167Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.17245615
168Pertussis_Homo sapiens_hsa051330.16495713
169Asthma_Homo sapiens_hsa053100.15384579
170Adipocytokine signaling pathway_Homo sapiens_hsa049200.14848790
171Peroxisome_Homo sapiens_hsa041460.14376335
172Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.11895494
173Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.10897681

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