GP1BA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)7.45284384
2* thrombin receptor signaling pathway (GO:0070493)6.56458333
3megakaryocyte development (GO:0035855)6.43629363
4production of molecular mediator involved in inflammatory response (GO:0002532)6.22492357
5definitive hemopoiesis (GO:0060216)6.18409038
6regulation of platelet aggregation (GO:0090330)6.04809456
7regulation of platelet activation (GO:0010543)5.64512142
8positive regulation of mast cell degranulation (GO:0043306)5.63500672
9positive regulation of mast cell activation involved in immune response (GO:0033008)5.63500672
10positive regulation of megakaryocyte differentiation (GO:0045654)5.60215580
11protein neddylation (GO:0045116)5.45934777
12leukocyte migration involved in inflammatory response (GO:0002523)5.32691026
13positive regulation of B cell differentiation (GO:0045579)5.17910351
14adenosine receptor signaling pathway (GO:0001973)5.16874262
15positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)5.10631139
16regulation of hypersensitivity (GO:0002883)5.08348495
17positive regulation of mast cell activation (GO:0033005)4.89938899
18angiotensin maturation (GO:0002003)4.89551624
19G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.79759663
20neutrophil activation (GO:0042119)4.70415320
21regulation of integrin activation (GO:0033623)4.68315466
22embryonic hemopoiesis (GO:0035162)4.68192091
23negative regulation of homotypic cell-cell adhesion (GO:0034111)4.56723049
24tyrosine phosphorylation of STAT protein (GO:0007260)4.46266599
25positive regulation of endothelial cell differentiation (GO:0045603)4.43897072
26negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.36531373
27positive regulation of leukocyte degranulation (GO:0043302)4.34701676
28DNA unwinding involved in DNA replication (GO:0006268)4.33810347
29positive regulation of myeloid leukocyte mediated immunity (GO:0002888)4.32288809
30mitotic sister chromatid cohesion (GO:0007064)4.28853225
31negative regulation of norepinephrine secretion (GO:0010700)4.26509149
32granulocyte activation (GO:0036230)4.20616084
33purinergic nucleotide receptor signaling pathway (GO:0035590)4.19792332
34lipoxygenase pathway (GO:0019372)4.15799029
35negative regulation of platelet activation (GO:0010544)4.15147242
36negative regulation of thymocyte apoptotic process (GO:0070244)4.13456067
37regulation of integrin-mediated signaling pathway (GO:2001044)4.12748029
38triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.03154737
39homotypic cell-cell adhesion (GO:0034109)3.98494752
40myeloid cell development (GO:0061515)3.97933580
41regulation of erythrocyte differentiation (GO:0045646)3.96860487
42regulation of lipoprotein metabolic process (GO:0050746)3.94932289
43negative regulation of phagocytosis (GO:0050765)3.90116646
44IMP biosynthetic process (GO:0006188)3.89709181
45DNA strand elongation involved in DNA replication (GO:0006271)3.85448930
46DNA strand elongation (GO:0022616)3.85038949
47one-carbon compound transport (GO:0019755)3.82852567
48regulation of mast cell degranulation (GO:0043304)3.80953346
49platelet degranulation (GO:0002576)3.78842937
50erythrocyte maturation (GO:0043249)3.73551402
51regulation of DNA endoreduplication (GO:0032875)3.70340351
52positive regulation of erythrocyte differentiation (GO:0045648)3.65119145
53positive regulation of hemostasis (GO:1900048)3.64449070
54positive regulation of blood coagulation (GO:0030194)3.64449070
55positive regulation of granulocyte differentiation (GO:0030854)3.62787096
56positive regulation of gamma-delta T cell activation (GO:0046645)3.62264452
57mast cell activation (GO:0045576)3.61833293
58granulocyte differentiation (GO:0030851)3.59062340
59positive regulation of macrophage differentiation (GO:0045651)3.55837263
60negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.55220840
61negative regulation of T-helper cell differentiation (GO:0045623)3.55220840
62* platelet activation (GO:0030168)3.54078361
63G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.54006943
64purinergic receptor signaling pathway (GO:0035587)3.50949018
65regulation of homotypic cell-cell adhesion (GO:0034110)3.50830117
66platelet formation (GO:0030220)3.48970277
67regulation of mast cell activation involved in immune response (GO:0033006)3.46913909
68histamine transport (GO:0051608)3.42311361
69leukocyte degranulation (GO:0043299)3.42168043
70leukotriene biosynthetic process (GO:0019370)3.40007101
71regulation of MHC class II biosynthetic process (GO:0045346)3.37934539
723-UTR-mediated mRNA stabilization (GO:0070935)3.34170489
73IMP metabolic process (GO:0046040)3.33258791
74negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.33081854
75regulation of protein heterodimerization activity (GO:0043497)3.32172179
76regulation of Golgi to plasma membrane protein transport (GO:0042996)3.31706336
77positive regulation of Rho protein signal transduction (GO:0035025)3.31335433
78histamine secretion (GO:0001821)3.31274193
79interferon-gamma production (GO:0032609)3.30811249
80ribosomal small subunit assembly (GO:0000028)3.30461123
81positive regulation of coagulation (GO:0050820)3.28536382
82secretory granule organization (GO:0033363)3.27606100
83mast cell activation involved in immune response (GO:0002279)3.27020743
84mast cell degranulation (GO:0043303)3.27020743
85telomere maintenance via semi-conservative replication (GO:0032201)3.25609542
86daunorubicin metabolic process (GO:0044597)3.25511769
87polyketide metabolic process (GO:0030638)3.25511769
88doxorubicin metabolic process (GO:0044598)3.25511769
89regulation of T-helper 1 cell differentiation (GO:0045625)3.23097783
90mesodermal cell differentiation (GO:0048333)3.20259213
91germ cell migration (GO:0008354)3.20139910
92regulation of mast cell activation (GO:0033003)3.17024680
93regulation of regulatory T cell differentiation (GO:0045589)3.16109958
94* blood coagulation, intrinsic pathway (GO:0007597)3.15764058
95positive regulation of systemic arterial blood pressure (GO:0003084)3.14954213
96positive regulation of immunoglobulin mediated immune response (GO:0002891)3.13965760
97positive regulation of B cell mediated immunity (GO:0002714)3.13965760
98regulation of macrophage derived foam cell differentiation (GO:0010743)3.13872370
99regulation of megakaryocyte differentiation (GO:0045652)3.13659411
100regulation of B cell differentiation (GO:0045577)3.13495458
101positive regulation of cAMP-mediated signaling (GO:0043950)3.12227896
102folic acid-containing compound biosynthetic process (GO:0009396)3.11552345
103DNA replication initiation (GO:0006270)3.09878881
104platelet dense granule organization (GO:0060155)3.09794006
105myeloid cell activation involved in immune response (GO:0002275)3.09465340
106regulation of memory T cell differentiation (GO:0043380)3.08900803
107low-density lipoprotein particle remodeling (GO:0034374)3.06931282
108negative regulation of T cell apoptotic process (GO:0070233)3.06650379
109protoporphyrinogen IX metabolic process (GO:0046501)3.03803972
110regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.03345357
111erythrocyte differentiation (GO:0030218)3.02106503
112negative regulation of heart rate (GO:0010459)3.01206255
113negative regulation of neural precursor cell proliferation (GO:2000178)2.98183842
114positive regulation of receptor recycling (GO:0001921)2.97967046
115regulation of leukocyte degranulation (GO:0043300)2.96615180
116pore complex assembly (GO:0046931)2.95216917
117phagocytosis, engulfment (GO:0006911)2.93880896
118dendritic cell chemotaxis (GO:0002407)2.92090131
119negative regulation of erythrocyte differentiation (GO:0045647)2.91954635
120positive regulation of regulated secretory pathway (GO:1903307)2.91332544
121protoporphyrinogen IX biosynthetic process (GO:0006782)2.91010350
122cellular extravasation (GO:0045123)2.90175819
123regulation of myeloid leukocyte mediated immunity (GO:0002886)2.89755679
124antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.89041415
125regulation of endothelial cell differentiation (GO:0045601)2.89011896
126negative regulation of interleukin-17 production (GO:0032700)2.88998961
127negative regulation of stress fiber assembly (GO:0051497)2.88742407
128maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.88630343
129regulation of B cell apoptotic process (GO:0002902)2.87227146
130erythrocyte development (GO:0048821)2.85827065
131regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.84445639
132mitotic nuclear envelope disassembly (GO:0007077)2.84443339
133T cell homeostasis (GO:0043029)2.84214872
134termination of G-protein coupled receptor signaling pathway (GO:0038032)2.84157587
135microglial cell activation (GO:0001774)2.84045396
136termination of signal transduction (GO:0023021)2.83795622
137heme biosynthetic process (GO:0006783)2.82906034
138positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.82007319
139Arp2/3 complex-mediated actin nucleation (GO:0034314)2.81393426
140positive regulation of isotype switching (GO:0045830)2.81393041
141positive regulation of immune response to tumor cell (GO:0002839)2.79559392
142regulation of immune response to tumor cell (GO:0002837)2.79559392
143regulation of response to tumor cell (GO:0002834)2.79559392
144positive regulation of response to tumor cell (GO:0002836)2.79559392
145actin nucleation (GO:0045010)2.79523420
146negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.78453749
147porphyrin-containing compound biosynthetic process (GO:0006779)2.77227263
148positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.76090281
149regulation of T-helper 2 cell differentiation (GO:0045628)2.75769815
150superoxide anion generation (GO:0042554)2.75485627
151autophagic vacuole fusion (GO:0000046)2.74911345
152phospholipid scrambling (GO:0017121)2.73752179
153angiogenesis involved in wound healing (GO:0060055)2.72813462
154polyamine biosynthetic process (GO:0006596)2.72686443
155protein localization to kinetochore (GO:0034501)2.72594866
156regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.72165790
157heparin biosynthetic process (GO:0030210)2.71868790
158heparin metabolic process (GO:0030202)2.71868790
159actin filament polymerization (GO:0030041)2.70986882
160positive regulation by organism of defense response of other organism involved in symbiotic interact2.70878837
161modulation by symbiont of host immune response (GO:0052553)2.70878837
162modulation by symbiont of host defense response (GO:0052031)2.70878837
163modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.70878837
164positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.70343122
165positive regulation of histone deacetylation (GO:0031065)2.69335384
166cytokine production involved in immune response (GO:0002367)2.67753366
167telomere maintenance via recombination (GO:0000722)2.66420616
168platelet aggregation (GO:0070527)2.65303666
169regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.64773180
170B cell receptor signaling pathway (GO:0050853)2.63144094
171alternative mRNA splicing, via spliceosome (GO:0000380)2.60731070
172translesion synthesis (GO:0019985)2.60663397
173negative regulation of bone mineralization (GO:0030502)2.59124765
174regulation of gamma-delta T cell differentiation (GO:0045586)2.58828374
175negative regulation of granulocyte differentiation (GO:0030853)2.58545555
176replication fork processing (GO:0031297)2.58062340
177membrane disassembly (GO:0030397)2.57801213
178nuclear envelope disassembly (GO:0051081)2.57801213
179DNA geometric change (GO:0032392)2.57729923
180mitotic recombination (GO:0006312)2.57430042
181negative regulation of DNA-dependent DNA replication (GO:2000104)2.56716926
182DNA replication checkpoint (GO:0000076)2.53153180
183negative regulation of RNA splicing (GO:0033119)2.52795298

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.56715561
2SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.51952579
3SCL_19346495_ChIP-Seq_HPC-7_Human4.46335913
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.68473299
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.43328465
6GATA1_22025678_ChIP-Seq_K562_Human3.40586593
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.34547926
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.12944523
9MYC_22102868_ChIP-Seq_BL_Human3.00889191
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.89343015
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.88257290
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.47069349
13* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.45580242
14VDR_21846776_ChIP-Seq_THP-1_Human2.44170820
15* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.43466772
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.41462905
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.40392813
18* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.37625549
19TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.28284086
20* GATA1_19941827_ChIP-Seq_MEL_Mouse2.25411056
21GATA2_21666600_ChIP-Seq_HMVEC_Human2.25400118
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21489765
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.15137227
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14014771
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.11849713
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.10703645
27* GATA1_22383799_ChIP-Seq_G1ME_Mouse2.06251670
28MYB_21317192_ChIP-Seq_ERMYB_Mouse2.01909017
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.99024805
30GATA1_19941826_ChIP-Seq_K562_Human1.90972894
31TCF7_22412390_ChIP-Seq_EML_Mouse1.90609988
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.89247389
33ELK4_26923725_Chip-Seq_MESODERM_Mouse1.80989601
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.79544906
35* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.76651580
36CIITA_25753668_ChIP-Seq_RAJI_Human1.75072648
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.74876506
38* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74644586
39UTX_26944678_Chip-Seq_JUKART_Human1.74334616
40* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.73106227
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.72941748
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.72730270
43MAF_26560356_Chip-Seq_TH1_Human1.70298346
44SRY_22984422_ChIP-ChIP_TESTIS_Rat1.68470504
45SPI1_23547873_ChIP-Seq_NB4_Human1.64874559
46* GATA1_19941827_ChIP-Seq_MEL86_Mouse1.64593330
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.62428958
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.61600154
49VDR_24763502_ChIP-Seq_THP-1_Human1.59609395
50* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.57222646
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.56913259
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.56524609
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.53437867
54AR_21909140_ChIP-Seq_LNCAP_Human1.52426007
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49945697
56MYB_26560356_Chip-Seq_TH2_Human1.46683732
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.44902619
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.44369167
59PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44330824
60MYB_26560356_Chip-Seq_TH1_Human1.42283402
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39863141
62PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39219889
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.38252672
64MYC_19030024_ChIP-ChIP_MESCs_Mouse1.38085169
65MYC_19079543_ChIP-ChIP_MESCs_Mouse1.36410008
66NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33781798
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33625830
68MYC_18358816_ChIP-ChIP_MESCs_Mouse1.32334350
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30621517
70FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.29955602
71SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29298222
72GATA3_27048872_Chip-Seq_THYMUS_Human1.29158750
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.26965487
74HTT_18923047_ChIP-ChIP_STHdh_Human1.26726133
75GATA2_19941826_ChIP-Seq_K562_Human1.26497910
76STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25956126
77STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25039493
78XRN2_22483619_ChIP-Seq_HELA_Human1.25012519
79FOXP3_21729870_ChIP-Seq_TREG_Human1.24391483
80SPI1_23127762_ChIP-Seq_K562_Human1.23605081
81NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21780911
82FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21540754
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20956351
84KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.20568820
85KDM2B_26808549_Chip-Seq_DND41_Human1.18113435
86ELK3_25401928_ChIP-Seq_HUVEC_Human1.17531488
87RUNX_20019798_ChIP-Seq_JUKART_Human1.16794355
88* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16661335
89KDM5A_27292631_Chip-Seq_BREAST_Human1.15471546
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15315682
91IRF8_27001747_Chip-Seq_BMDM_Mouse1.13186026
92VDR_23849224_ChIP-Seq_CD4+_Human1.11979222
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11695257
94EST1_17652178_ChIP-ChIP_JURKAT_Human1.09726596
95NCOR1_26117541_ChIP-Seq_K562_Human1.07894719
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07315592
97SPI1_20517297_ChIP-Seq_HL60_Human1.06799280
98E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06762839
99ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03523804
100MAF_26560356_Chip-Seq_TH2_Human1.02866689
101CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02863288
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02761376
103* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02690741
104GATA3_26560356_Chip-Seq_TH2_Human1.01520266
105ETS1_20019798_ChIP-Seq_JURKAT_Human0.99947572
106THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99626989
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98827440
108NELFA_20434984_ChIP-Seq_ESCs_Mouse0.98591886
109KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98387254
110IRF8_21731497_ChIP-ChIP_J774_Mouse0.98210203
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98071084
112ETS1_22383799_ChIP-Seq_G1ME_Mouse0.97486918
113PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96254186
114* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95911758
115HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.95038745
116CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94580289
117STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.93870816
118MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92135196
119CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91510858
120CREB1_15753290_ChIP-ChIP_HEK293T_Human0.91130834
121E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90577327
122KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.90033492
123VDR_24787735_ChIP-Seq_THP-1_Human0.88469589
124SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88432208
125STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87158257
126PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86552639
127PU_27001747_Chip-Seq_BMDM_Mouse0.85761834
128PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85590105
129FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.85227287
130* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85149521
131YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84413654
132* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84071586
133SALL4_22934838_ChIP-ChIP_CD34+_Human0.82582312
134TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81792410
135SRF_21415370_ChIP-Seq_HL-1_Mouse0.81588925
136CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81285211
137STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.76906658
138* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73339251
139ESR1_20079471_ChIP-ChIP_T-47D_Human0.73140121
140SMAD_19615063_ChIP-ChIP_OVARY_Human0.72160321
141EZH2_22144423_ChIP-Seq_EOC_Human0.70103737
142STAT1_20625510_ChIP-Seq_HELA_Human0.69158219
143CTCF_21964334_ChIP-Seq_BJAB-B_Human0.68525666
144SMRT_27268052_Chip-Seq_Bcells_Human0.68485763
145RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.68352079

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH5.09776489
2MP0002396_abnormal_hematopoietic_system4.81043760
3MP0004147_increased_porphyrin_level3.80579236
4MP0008057_abnormal_DNA_replication3.42248025
5MP0004808_abnormal_hematopoietic_stem3.34881190
6MP0005464_abnormal_platelet_physiology3.30954150
7MP0000465_gastrointestinal_hemorrhage3.21308919
8MP0003656_abnormal_erythrocyte_physiolo2.80914647
9MP0005397_hematopoietic_system_phenotyp2.75451988
10MP0001545_abnormal_hematopoietic_system2.75451988
11MP0002877_abnormal_melanocyte_morpholog2.73356656
12MP0010094_abnormal_chromosome_stability2.69241813
13MP0003693_abnormal_embryo_hatching2.51826851
14MP0003111_abnormal_nucleus_morphology2.43156197
15MP0006054_spinal_hemorrhage2.41404981
16* MP0002398_abnormal_bone_marrow2.23552091
17MP0003077_abnormal_cell_cycle1.97962088
18MP0002722_abnormal_immune_system1.97934895
19MP0000689_abnormal_spleen_morphology1.86406169
20MP0010307_abnormal_tumor_latency1.82864164
21MP0004510_myositis1.78703707
22MP0001800_abnormal_humoral_immune1.71798874
23MP0003763_abnormal_thymus_physiology1.71209549
24MP0001851_eye_inflammation1.70701732
25MP0001853_heart_inflammation1.70543748
26MP0005058_abnormal_lysosome_morphology1.69451485
27MP0008775_abnormal_heart_ventricle1.66136187
28MP0004947_skin_inflammation1.65821691
29MP0010352_gastrointestinal_tract_polyps1.63914156
30* MP0002429_abnormal_blood_cell1.62496533
31MP0005671_abnormal_response_to1.61116249
32MP0005387_immune_system_phenotype1.60433989
33MP0001790_abnormal_immune_system1.60433989
34MP0003300_gastrointestinal_ulcer1.60021537
35MP0002420_abnormal_adaptive_immunity1.59055271
36MP0008058_abnormal_DNA_repair1.58307512
37MP0000716_abnormal_immune_system1.57862409
38MP0001819_abnormal_immune_cell1.56680333
39MP0005167_abnormal_blood-brain_barrier1.56216496
40MP0000230_abnormal_systemic_arterial1.54513077
41MP0001835_abnormal_antigen_presentation1.53728566
42MP0000703_abnormal_thymus_morphology1.50642158
43MP0002452_abnormal_antigen_presenting1.49248324
44MP0002723_abnormal_immune_serum1.47776283
45MP0003436_decreased_susceptibility_to1.46625886
46MP0004036_abnormal_muscle_relaxation1.46190577
47MP0008007_abnormal_cellular_replicative1.45903850
48MP0001533_abnormal_skeleton_physiology1.45056179
49MP0000490_abnormal_crypts_of1.44361397
50MP0002132_abnormal_respiratory_system1.41997878
51MP0005000_abnormal_immune_tolerance1.41316381
52MP0003566_abnormal_cell_adhesion1.39282670
53MP0002419_abnormal_innate_immunity1.38789853
54MP0003303_peritoneal_inflammation1.38391658
55MP0005174_abnormal_tail_pigmentation1.37762870
56MP0005025_abnormal_response_to1.33878749
57MP0005075_abnormal_melanosome_morpholog1.30803745
58MP0005083_abnormal_biliary_tract1.30400513
59MP0004957_abnormal_blastocyst_morpholog1.28980906
60MP0003638_abnormal_response/metabolism_1.28955102
61MP0009333_abnormal_splenocyte_physiolog1.27655007
62MP0000343_altered_response_to1.27133053
63MP0003828_pulmonary_edema1.26576323
64MP0000858_altered_metastatic_potential1.26067522
65MP0001663_abnormal_digestive_system1.25772065
66MP0009764_decreased_sensitivity_to1.25576205
67MP0002405_respiratory_system_inflammati1.24863181
68MP0009278_abnormal_bone_marrow1.24848388
69MP0002736_abnormal_nociception_after1.22603758
70MP0002148_abnormal_hypersensitivity_rea1.21834304
71MP0001915_intracranial_hemorrhage1.21020846
72MP0010155_abnormal_intestine_physiology1.17793552
73MP0004084_abnormal_cardiac_muscle1.15706461
74MP0005084_abnormal_gallbladder_morpholo1.13989789
75MP0002019_abnormal_tumor_incidence1.13859994
76MP0003724_increased_susceptibility_to1.12971459
77MP0002166_altered_tumor_susceptibility1.11284153
78MP0000685_abnormal_immune_system1.11160103
79MP0003879_abnormal_hair_cell1.10393669
80MP0000313_abnormal_cell_death1.08729907
81MP0008770_decreased_survivor_rate1.08024538
82MP0003567_abnormal_fetal_cardiomyocyte1.06068868
83MP0001730_embryonic_growth_arrest1.03398730
84MP0003866_abnormal_defecation1.03258155
85MP0000015_abnormal_ear_pigmentation1.03212976
86MP0002998_abnormal_bone_remodeling0.99159250
87MP0009765_abnormal_xenobiotic_induced0.98759783
88MP0001845_abnormal_inflammatory_respons0.94480287
89MP0008469_abnormal_protein_level0.94188770
90MP0005409_darkened_coat_color0.93146499
91MP0008874_decreased_physiological_sensi0.92416946
92MP0001879_abnormal_lymphatic_vessel0.92315941
93MP0002086_abnormal_extraembryonic_tissu0.91949371
94MP0002006_tumorigenesis0.91593208
95MP0002837_dystrophic_cardiac_calcinosis0.91302402
96MP0000350_abnormal_cell_proliferation0.90204530
97MP0004215_abnormal_myocardial_fiber0.89237069
98MP0000598_abnormal_liver_morphology0.89027415
99MP0003943_abnormal_hepatobiliary_system0.88989647
100MP0003453_abnormal_keratinocyte_physiol0.88691391
101MP0004484_altered_response_of0.88166651
102MP0005410_abnormal_fertilization0.87679560
103MP0009785_altered_susceptibility_to0.85194152
104MP0009763_increased_sensitivity_to0.84815097
105MP0003984_embryonic_growth_retardation0.83853735
106MP0003091_abnormal_cell_migration0.83790705
107MP0008872_abnormal_physiological_respon0.83469644
108MP0003448_altered_tumor_morphology0.83157284
109MP0005023_abnormal_wound_healing0.81148743
110MP0010329_abnormal_lipoprotein_level0.81133051
111MP0004883_abnormal_blood_vessel0.81080487
112MP0005076_abnormal_cell_differentiation0.80609425
113MP0002088_abnormal_embryonic_growth/wei0.80589138
114MP0010630_abnormal_cardiac_muscle0.80012501
115MP0001765_abnormal_ion_homeostasis0.79457921
116MP0002733_abnormal_thermal_nociception0.78897192
117MP0003172_abnormal_lysosome_physiology0.78638321
118MP0001697_abnormal_embryo_size0.78140160
119MP0006082_CNS_inflammation0.77846862
120* MP0009642_abnormal_blood_homeostasis0.77014577
121MP0003191_abnormal_cellular_cholesterol0.75791869
122MP0008260_abnormal_autophagy0.75787286
123MP0010368_abnormal_lymphatic_system0.74374423
124MP0005381_digestive/alimentary_phenotyp0.73799904
125MP0000249_abnormal_blood_vessel0.72632939
126MP0005535_abnormal_body_temperature0.72227345
127MP0005165_increased_susceptibility_to0.72062855
128MP0003075_altered_response_to0.71951899
129MP0002095_abnormal_skin_pigmentation0.71481273
130MP0001672_abnormal_embryogenesis/_devel0.71340056
131MP0005380_embryogenesis_phenotype0.71340056
132MP0002080_prenatal_lethality0.71283556
133MP0001968_abnormal_touch/_nociception0.71216957
134MP0005330_cardiomyopathy0.70684010
135MP0004381_abnormal_hair_follicle0.69812884
136MP0009840_abnormal_foam_cell0.69644073
137MP0001873_stomach_inflammation0.68392670
138MP0002128_abnormal_blood_circulation0.67942987
139MP0004130_abnormal_muscle_cell0.67085978
140MP0005646_abnormal_pituitary_gland0.66275870
141MP0009697_abnormal_copulation0.64240005
142MP0005310_abnormal_salivary_gland0.64015314
143MP0003183_abnormal_peptide_metabolism0.63259882
144MP0001544_abnormal_cardiovascular_syste0.60569156
145MP0005385_cardiovascular_system_phenoty0.60569156

Predicted human phenotypes

RankGene SetZ-score
1* Petechiae (HP:0000967)7.18786085
2* Prolonged bleeding time (HP:0003010)6.70332518
3* Abnormal platelet volume (HP:0011876)5.68190839
4* Increased mean platelet volume (HP:0011877)5.62164821
5Impaired platelet aggregation (HP:0003540)5.61041032
6Abnormal platelet function (HP:0011869)5.61041032
7Abnormality of the heme biosynthetic pathway (HP:0010472)5.59286307
8Spontaneous hematomas (HP:0007420)5.30795531
9Hyperlipoproteinemia (HP:0010980)5.16835801
10Chronic otitis media (HP:0000389)4.93856287
11* Purpura (HP:0000979)4.90210120
12* Menorrhagia (HP:0000132)4.80128001
13* Epistaxis (HP:0000421)4.24927760
14Volvulus (HP:0002580)4.18716849
15* Poikilocytosis (HP:0004447)3.95762784
16Aplastic anemia (HP:0001915)3.77371870
17Acanthocytosis (HP:0001927)3.65617594
18Abnormal number of erythroid precursors (HP:0012131)3.54972678
19Recurrent viral infections (HP:0004429)3.49358413
20Reticulocytosis (HP:0001923)3.45180287
21* Gingival bleeding (HP:0000225)3.44743204
22Cellulitis (HP:0100658)3.43321073
23Dyschromatopsia (HP:0007641)3.40791754
24IgM deficiency (HP:0002850)3.29302918
25Abnormality of cells of the erythroid lineage (HP:0012130)3.29146962
26Conjunctival telangiectasia (HP:0000524)3.26772678
27Abnormal pupillary function (HP:0007686)3.23694005
28Stomatitis (HP:0010280)3.10667907
29Panhypogammaglobulinemia (HP:0003139)2.98088218
30Abnormality of the fingertips (HP:0001211)2.97128829
31Abnormality of the vasculature of the conjunctiva (HP:0008054)2.96080995
32Recurrent bacterial skin infections (HP:0005406)2.95498159
33Paralysis (HP:0003470)2.94188527
34Abnormality of reticulocytes (HP:0004312)2.93477199
35Acute myeloid leukemia (HP:0004808)2.89741374
36Thrombocytosis (HP:0001894)2.84501060
37Abnormality of the prostate (HP:0008775)2.82211579
38Recurrent abscess formation (HP:0002722)2.79459618
39Hepatosplenomegaly (HP:0001433)2.69813558
40Eczematoid dermatitis (HP:0000976)2.67809728
41Chronic obstructive pulmonary disease (HP:0006510)2.59492512
42Obstructive lung disease (HP:0006536)2.59492512
43Agammaglobulinemia (HP:0004432)2.53962692
44Polycythemia (HP:0001901)2.51158044
45Encephalitis (HP:0002383)2.50702184
46Long eyelashes (HP:0000527)2.50402183
47Joint hemorrhage (HP:0005261)2.49467017
48Chest pain (HP:0100749)2.45474500
49Tinnitus (HP:0000360)2.44908080
50Acute lymphatic leukemia (HP:0006721)2.44702023
51Viral hepatitis (HP:0006562)2.43614133
52Myelodysplasia (HP:0002863)2.40013690
53Episodic fever (HP:0001954)2.39328880
54Papilledema (HP:0001085)2.37896566
55Joint swelling (HP:0001386)2.35052472
56Autoimmune hemolytic anemia (HP:0001890)2.33802388
57Increased IgM level (HP:0003496)2.28440942
58Abnormality of the thoracic spine (HP:0100711)2.25956676
59Oral leukoplakia (HP:0002745)2.24604546
60Abnormality of macrophages (HP:0004311)2.23820884
61Increased serum ferritin (HP:0003281)2.20306967
62Hypochromic anemia (HP:0001931)2.17841212
63Hyperbilirubinemia (HP:0002904)2.13383753
64Pallor (HP:0000980)2.13242455
65Increased density of long bones (HP:0006392)2.08814428
66Recurrent fungal infections (HP:0002841)2.07895806
67Upper limb muscle weakness (HP:0003484)2.06957674
68Neoplasm of head and neck (HP:0012288)2.06374132
69Esophageal neoplasm (HP:0100751)2.06374132
70Abnormal auditory evoked potentials (HP:0006958)2.06225463
71* Bruising susceptibility (HP:0000978)2.05806174
72Reticulocytopenia (HP:0001896)2.01560598
73Hyperthyroidism (HP:0000836)2.01218539
74Lymphoma (HP:0002665)1.99171000
75Spontaneous abortion (HP:0005268)1.98845766
76Inflammation of the large intestine (HP:0002037)1.97609757
77Xanthomatosis (HP:0000991)1.96816049
78Abnormality of iron homeostasis (HP:0011031)1.96379515
7911 pairs of ribs (HP:0000878)1.94572692
80Muscle fiber atrophy (HP:0100295)1.94148119
81Vertigo (HP:0002321)1.94055681
82Elevated erythrocyte sedimentation rate (HP:0003565)1.93680239
83Pancreatic islet-cell hyperplasia (HP:0004510)1.93001597
84Male infertility (HP:0003251)1.92961731
85Arterial thrombosis (HP:0004420)1.90892633
86Papillary thyroid carcinoma (HP:0002895)1.90293342
87Broad palm (HP:0001169)1.88427111
88Keratoconjunctivitis sicca (HP:0001097)1.86932714
89Gastrointestinal inflammation (HP:0004386)1.86599690
90Depressed nasal tip (HP:0000437)1.85683337
91Distal lower limb amyotrophy (HP:0008944)1.84930719
92Meningitis (HP:0001287)1.84079150
93Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82186464
94Abnormality of lateral ventricle (HP:0030047)1.82161118
95Nonimmune hydrops fetalis (HP:0001790)1.80661913
96Transitional cell carcinoma of the bladder (HP:0006740)1.79745820
97Ulnar deviation of the wrist (HP:0003049)1.77911668
98Amaurosis fugax (HP:0100576)1.77494433
99Leiomyosarcoma (HP:0100243)1.77380728
100Uterine leiomyosarcoma (HP:0002891)1.77380728
101Myositis (HP:0100614)1.77098762
102Muscle fibrillation (HP:0010546)1.76589089
103Myocardial infarction (HP:0001658)1.76545606
104Optic neuritis (HP:0100653)1.76210063
105Retrobulbar optic neuritis (HP:0100654)1.76210063
106Urethral obstruction (HP:0000796)1.74988473
107Hypochromic microcytic anemia (HP:0004840)1.74759255
108Thrombophlebitis (HP:0004418)1.74174159
109Dysostosis multiplex (HP:0000943)1.73673619
110Recurrent skin infections (HP:0001581)1.70926145
111Abnormality of the right ventricle (HP:0001707)1.70861070
112Leukocytosis (HP:0001974)1.70418267
113Exertional dyspnea (HP:0002875)1.70405763
114Insomnia (HP:0100785)1.69982448
115Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.69000653
116Granulocytopenia (HP:0001913)1.68791351
117Type 2 muscle fiber atrophy (HP:0003554)1.68413591
118Short middle phalanx of the 5th finger (HP:0004220)1.68371511
119Orchitis (HP:0100796)1.68025039
120Ventricular fibrillation (HP:0001663)1.67535376
121Prominent nose (HP:0000448)1.67243362
122Abnormality of transition element cation homeostasis (HP:0011030)1.67193450
123Bladder neoplasm (HP:0009725)1.67141101
124Bladder carcinoma (HP:0002862)1.67141101
125Vasculitis (HP:0002633)1.66074324
126Increased nuchal translucency (HP:0010880)1.65517189
127Gastrointestinal infarctions (HP:0005244)1.65189329
128Abnormality of binocular vision (HP:0011514)1.64232428
129Diplopia (HP:0000651)1.64232428
130Bone marrow hypocellularity (HP:0005528)1.63759507
131Chromsome breakage (HP:0040012)1.62813848
132Decreased central vision (HP:0007663)1.61350984
133Hepatitis (HP:0012115)1.60848428
134Abnormality of the common coagulation pathway (HP:0010990)1.60777507
135High pitched voice (HP:0001620)1.59689916
136Tongue fasciculations (HP:0001308)1.58895027
137Short palpebral fissure (HP:0012745)1.58424129
138Osteomyelitis (HP:0002754)1.57792045
139Keratoconjunctivitis (HP:0001096)1.57582819
140Cutis marmorata (HP:0000965)1.57543671
141Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.56967382
142Cerebral ischemia (HP:0002637)1.56793669
143Microcytic anemia (HP:0001935)1.56469220
144Hyperacusis (HP:0010780)1.56026142
145Nausea (HP:0002018)1.54757043
146Verrucae (HP:0200043)1.54476423
147Papilloma (HP:0012740)1.54476423
148Ependymoma (HP:0002888)1.54400788
149Urticaria (HP:0001025)1.54378558
150Abnormality of the left ventricular outflow tract (HP:0011103)1.54255943
151Subaortic stenosis (HP:0001682)1.54255943
152Generalized aminoaciduria (HP:0002909)1.53254879
153Basal ganglia calcification (HP:0002135)1.53056508
154Hypophosphatemic rickets (HP:0004912)1.50591455
155Pulmonary embolism (HP:0002204)1.48586911
156Testicular neoplasm (HP:0010788)1.47945932
157Eosinophilia (HP:0001880)1.47033159
158Arthralgia (HP:0002829)1.41405640
159Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.39202403

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK46.18433878
2MAP4K15.15488340
3BMX3.72108281
4CDC73.44714199
5MST43.32925251
6EEF2K3.27846447
7TXK2.92005300
8KIT2.90689780
9TAOK32.79020146
10PIM22.77254274
11MYLK2.53865577
12TSSK62.45851464
13PTK2B2.20439585
14PIK3CG2.12972407
15TEC1.98833664
16PLK41.92001854
17EIF2AK11.87648788
18MATK1.85400398
19FGR1.79733338
20CDK121.78959495
21BMPR21.75551357
22MAP3K101.73357442
23ZAP701.71625888
24SYK1.67528281
25BTK1.65750702
26ITK1.62875069
27PKN21.60369561
28PIM11.60028361
29IRAK41.57452310
30NME21.56343650
31TNK21.51831550
32GRK51.50938199
33TYK21.47134291
34STK31.46096088
35CLK11.37668193
36STK41.35041413
37WEE11.34088810
38BRD41.33000238
39CSK1.31003611
40CDK41.29903713
41KDR1.25561327
42JAK31.25057249
43TGFBR21.23551377
44CDK61.18947072
45ATR1.18351448
46MAP2K31.17063316
47PDK11.16504248
48ADRBK21.10183273
49ERN11.08299940
50PNCK1.06997501
51RPS6KB21.05200109
52STK101.02118854
53PDPK11.01495246
54NEK91.01301890
55ILK1.01252482
56IRAK11.01171324
57TRIB30.97660329
58MKNK10.96391868
59TTN0.95303632
60TIE10.94554342
61BMPR1B0.91858848
62LYN0.91376722
63SCYL20.87654308
64MAP3K50.87415686
65GRK60.86966586
66YES10.86794907
67TRPM70.85632312
68FLT30.83632711
69NEK20.83604201
70MARK30.82864694
71PAK10.81803837
72SRPK10.81761467
73CAMK1G0.81585909
74TAOK20.81222250
75CSF1R0.77539753
76TNIK0.77438137
77IRAK20.76983902
78MAPK120.75919402
79ZAK0.75258053
80JAK20.74173370
81MAP3K80.73570245
82PIK3CA0.72281309
83SIK20.72004042
84RET0.71827409
85MAP3K70.71506574
86CDK70.70430729
87LMTK20.70343661
88MAPK110.70053373
89MAPKAPK30.69360094
90BLK0.66519277
91MAPKAPK50.66440090
92EPHA30.66283099
93ALK0.65247261
94TGFBR10.64558945
95RPS6KL10.62948718
96RPS6KC10.62948718
97PDGFRB0.62545288
98MAP3K30.61705119
99RPS6KA60.61329711
100MAPKAPK20.61203595
101AURKB0.60270633
102LCK0.60162796
103RPS6KA20.59809294
104LRRK20.59689075
105PRKD10.58580020
106TAOK10.58359248
107FES0.58281399
108IKBKB0.57392735
109DAPK30.57054619
110ADRBK10.56038654
111STK240.55922467
112PAK20.55533976
113JAK10.55104836
114ERBB20.55050682
115HCK0.54825614
116CAMK1D0.54603423
117IRAK30.53085162
118VRK10.50872593
119ATM0.50563501
120SGK20.50435873
121NME10.49285690
122TESK20.49284155
123PRPF4B0.49106629
124HIPK20.48656692
125ACVR1B0.47818403
126SIK30.47099460
127SGK30.47076342
128RPS6KA40.46459130
129CAMKK20.46344605
130MAP3K60.46181809
131PRKACG0.46042758
132FYN0.45268239
133MAP2K10.44484710
134TBK10.44462432
135EPHB10.44413174
136TTK0.44279734
137PLK20.44041875
138CHEK20.43983866
139CHUK0.43873513
140MAP3K10.43525753
141MKNK20.43515078
142PRKCQ0.42545247
143MTOR0.41924590
144MAP3K110.41921769
145CHEK10.41784865
146FGFR40.41682024
147MAP3K140.40089863
148FGFR30.39409888
149DYRK30.39217870
150CDK20.37927918
151IKBKE0.37261072
152DAPK20.36272892
153NLK0.34061193
154PRKCD0.32611170
155MARK20.32326352
156DYRK1B0.29061513
157PRKG10.27940461
158CDC42BPA0.26412209
159TRIM280.26100709
160FER0.24010982
161SRC0.22618280

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.47739368
2Renin-angiotensin system_Homo sapiens_hsa046143.57126549
3Asthma_Homo sapiens_hsa053103.36754941
4Mismatch repair_Homo sapiens_hsa034303.13216031
5Cell cycle_Homo sapiens_hsa041102.36541755
6One carbon pool by folate_Homo sapiens_hsa006702.33378061
7SNARE interactions in vesicular transport_Homo sapiens_hsa041302.18556045
8* Hematopoietic cell lineage_Homo sapiens_hsa046402.15975938
9Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.06141112
10Spliceosome_Homo sapiens_hsa030402.05960786
11Chemokine signaling pathway_Homo sapiens_hsa040622.04675773
12Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.04404864
13* Platelet activation_Homo sapiens_hsa046112.03486343
14Base excision repair_Homo sapiens_hsa034101.99707807
15B cell receptor signaling pathway_Homo sapiens_hsa046621.91935860
16Homologous recombination_Homo sapiens_hsa034401.85601993
17Chronic myeloid leukemia_Homo sapiens_hsa052201.74624152
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.67880108
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.67068064
20p53 signaling pathway_Homo sapiens_hsa041151.65429991
21Ribosome_Homo sapiens_hsa030101.58329160
22Arachidonic acid metabolism_Homo sapiens_hsa005901.56325916
23Gap junction_Homo sapiens_hsa045401.51692213
24RNA transport_Homo sapiens_hsa030131.50790601
25Leishmaniasis_Homo sapiens_hsa051401.46961968
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.43499460
27Lysine degradation_Homo sapiens_hsa003101.38719105
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.38695128
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.36834689
30Toxoplasmosis_Homo sapiens_hsa051451.35831355
31Nitrogen metabolism_Homo sapiens_hsa009101.35117920
32Acute myeloid leukemia_Homo sapiens_hsa052211.31520175
33Measles_Homo sapiens_hsa051621.30371329
34Small cell lung cancer_Homo sapiens_hsa052221.28679176
35Staphylococcus aureus infection_Homo sapiens_hsa051501.28474371
36Endocytosis_Homo sapiens_hsa041441.26936503
37* ECM-receptor interaction_Homo sapiens_hsa045121.26420562
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.26198319
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25453027
40Vascular smooth muscle contraction_Homo sapiens_hsa042701.25378960
41Viral carcinogenesis_Homo sapiens_hsa052031.25217135
42Phospholipase D signaling pathway_Homo sapiens_hsa040721.24458591
43Hepatitis B_Homo sapiens_hsa051611.23598190
44Osteoclast differentiation_Homo sapiens_hsa043801.22197186
45Apoptosis_Homo sapiens_hsa042101.17184086
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16289723
47Primary immunodeficiency_Homo sapiens_hsa053401.16125489
48Herpes simplex infection_Homo sapiens_hsa051681.15035765
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.14467149
50Sulfur relay system_Homo sapiens_hsa041221.13394382
51Serotonergic synapse_Homo sapiens_hsa047261.13014622
52Non-small cell lung cancer_Homo sapiens_hsa052231.07922506
53Antigen processing and presentation_Homo sapiens_hsa046121.07278143
54Jak-STAT signaling pathway_Homo sapiens_hsa046301.07119589
55Phagosome_Homo sapiens_hsa041451.05407133
56Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04143970
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98790519
58Nucleotide excision repair_Homo sapiens_hsa034200.97375190
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96483523
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95708627
61Pancreatic secretion_Homo sapiens_hsa049720.95498959
62Pyrimidine metabolism_Homo sapiens_hsa002400.95237222
63Pancreatic cancer_Homo sapiens_hsa052120.95031731
64Alcoholism_Homo sapiens_hsa050340.94875356
65N-Glycan biosynthesis_Homo sapiens_hsa005100.94013986
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93081934
67Choline metabolism in cancer_Homo sapiens_hsa052310.92143373
68Rap1 signaling pathway_Homo sapiens_hsa040150.91684586
69Long-term depression_Homo sapiens_hsa047300.90487124
70Collecting duct acid secretion_Homo sapiens_hsa049660.89511493
71Thyroid cancer_Homo sapiens_hsa052160.89204956
72Glycerolipid metabolism_Homo sapiens_hsa005610.86886080
73mRNA surveillance pathway_Homo sapiens_hsa030150.86736381
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86127077
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86031278
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85907615
77Endometrial cancer_Homo sapiens_hsa052130.85361083
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.84520631
79VEGF signaling pathway_Homo sapiens_hsa043700.84132479
80Graft-versus-host disease_Homo sapiens_hsa053320.83804835
81Epstein-Barr virus infection_Homo sapiens_hsa051690.83793542
82Allograft rejection_Homo sapiens_hsa053300.82507083
83Renal cell carcinoma_Homo sapiens_hsa052110.81021377
84Viral myocarditis_Homo sapiens_hsa054160.80876614
85Focal adhesion_Homo sapiens_hsa045100.80514942
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80116293
87Legionellosis_Homo sapiens_hsa051340.80085535
88Fanconi anemia pathway_Homo sapiens_hsa034600.79840562
89RNA degradation_Homo sapiens_hsa030180.79607195
90HTLV-I infection_Homo sapiens_hsa051660.73732369
91MicroRNAs in cancer_Homo sapiens_hsa052060.72065494
92Systemic lupus erythematosus_Homo sapiens_hsa053220.70647837
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70570517
94Autoimmune thyroid disease_Homo sapiens_hsa053200.69767366
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69482822
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.68623451
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67834246
98Non-homologous end-joining_Homo sapiens_hsa034500.65903824
99Influenza A_Homo sapiens_hsa051640.65881585
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64675238
101Complement and coagulation cascades_Homo sapiens_hsa046100.64158185
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62086226
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61303364
104Dilated cardiomyopathy_Homo sapiens_hsa054140.61103255
105Salmonella infection_Homo sapiens_hsa051320.61013482
106Galactose metabolism_Homo sapiens_hsa000520.60177399
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.59607112
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59012160
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.57225620
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57181888
111Pentose phosphate pathway_Homo sapiens_hsa000300.56374416
112Notch signaling pathway_Homo sapiens_hsa043300.55667928
113TNF signaling pathway_Homo sapiens_hsa046680.55482202
114Ras signaling pathway_Homo sapiens_hsa040140.54950666
115Glioma_Homo sapiens_hsa052140.54219429
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.53591668
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52952648
118Colorectal cancer_Homo sapiens_hsa052100.52566657
119HIF-1 signaling pathway_Homo sapiens_hsa040660.51890583
120Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51500292
121Olfactory transduction_Homo sapiens_hsa047400.51494204
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47886899
123T cell receptor signaling pathway_Homo sapiens_hsa046600.47761603
124Insulin resistance_Homo sapiens_hsa049310.47691865
125Rheumatoid arthritis_Homo sapiens_hsa053230.47199445
126Calcium signaling pathway_Homo sapiens_hsa040200.46821649
127Other glycan degradation_Homo sapiens_hsa005110.46252094
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45185106
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44888715
130Amoebiasis_Homo sapiens_hsa051460.44728668
131FoxO signaling pathway_Homo sapiens_hsa040680.44683483
132Morphine addiction_Homo sapiens_hsa050320.44596457
133RNA polymerase_Homo sapiens_hsa030200.44030151
134Toll-like receptor signaling pathway_Homo sapiens_hsa046200.43976998
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.43268764
136Linoleic acid metabolism_Homo sapiens_hsa005910.42377400
137Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42118357
138Malaria_Homo sapiens_hsa051440.41523996
139Renin secretion_Homo sapiens_hsa049240.41225649
140African trypanosomiasis_Homo sapiens_hsa051430.40923655
141Tuberculosis_Homo sapiens_hsa051520.40249281
142Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39426553
143Biosynthesis of amino acids_Homo sapiens_hsa012300.38859298
144ABC transporters_Homo sapiens_hsa020100.38409441
145Tryptophan metabolism_Homo sapiens_hsa003800.38146137
146Leukocyte transendothelial migration_Homo sapiens_hsa046700.37138441
147Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36286846
148Shigellosis_Homo sapiens_hsa051310.35751234
149Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35528349
150RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33953021
151Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33859963
152Pertussis_Homo sapiens_hsa051330.32919771
153Carbon metabolism_Homo sapiens_hsa012000.32704628
154Sphingolipid signaling pathway_Homo sapiens_hsa040710.32489061
155Central carbon metabolism in cancer_Homo sapiens_hsa052300.31994516
156Purine metabolism_Homo sapiens_hsa002300.31244837
157Ovarian steroidogenesis_Homo sapiens_hsa049130.29763120

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