GORAB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the golgin family, a group of coiled-coil proteins localized to the Golgi. The encoded protein may function in the secretory pathway. The encoded protein, which also localizes to the cytoplasm, was identified by interactions with the N-terminal kinase-like protein, and thus it may function in mitosis. Mutations in this gene have been associated with geroderma osteodysplastica. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)4.35891072
2nuclear pore organization (GO:0006999)4.17934109
3CENP-A containing nucleosome assembly (GO:0034080)4.15824410
4regulation of centriole replication (GO:0046599)4.06395670
5chromatin remodeling at centromere (GO:0031055)4.00211299
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.99566441
7telomere maintenance via semi-conservative replication (GO:0032201)3.91503465
8cullin deneddylation (GO:0010388)3.84218664
9DNA unwinding involved in DNA replication (GO:0006268)3.80426886
10mitotic recombination (GO:0006312)3.77843522
11ribosome assembly (GO:0042255)3.75582024
12telomere maintenance via recombination (GO:0000722)3.74718375
13IMP biosynthetic process (GO:0006188)3.71683570
14DNA strand elongation involved in DNA replication (GO:0006271)3.70885340
15Golgi transport vesicle coating (GO:0048200)3.70408300
16COPI coating of Golgi vesicle (GO:0048205)3.70408300
17mitotic metaphase plate congression (GO:0007080)3.69183318
18regulation of helicase activity (GO:0051095)3.57204424
19kinetochore organization (GO:0051383)3.53564143
20purine nucleobase biosynthetic process (GO:0009113)3.53237350
21DNA strand elongation (GO:0022616)3.45816817
22mitotic sister chromatid cohesion (GO:0007064)3.45721279
23DNA replication-independent nucleosome organization (GO:0034724)3.42157016
24DNA replication-independent nucleosome assembly (GO:0006336)3.42157016
25DNA replication initiation (GO:0006270)3.41708719
26tRNA methylation (GO:0030488)3.40130198
27establishment of integrated proviral latency (GO:0075713)3.39920485
28attachment of spindle microtubules to kinetochore (GO:0008608)3.37843965
29histone exchange (GO:0043486)3.37326321
30regulation of cilium movement (GO:0003352)3.32312375
31protein localization to kinetochore (GO:0034501)3.30913922
32nucleobase biosynthetic process (GO:0046112)3.30005084
33protein deneddylation (GO:0000338)3.26956694
34deoxyribonucleotide biosynthetic process (GO:0009263)3.24753387
35regulation of sister chromatid cohesion (GO:0007063)3.24523146
36histone-serine phosphorylation (GO:0035404)3.21453893
37formation of translation preinitiation complex (GO:0001731)3.20812540
38water-soluble vitamin biosynthetic process (GO:0042364)3.20732751
39metaphase plate congression (GO:0051310)3.17375073
40nucleotide-excision repair, DNA gap filling (GO:0006297)3.16852560
41eosinophil chemotaxis (GO:0048245)3.16354594
42DNA replication checkpoint (GO:0000076)3.12290319
43regulation of centrosome cycle (GO:0046605)3.09536994
44telomere maintenance via telomere lengthening (GO:0010833)3.08938350
45nuclear pore complex assembly (GO:0051292)3.08802632
46nucleobase-containing small molecule interconversion (GO:0015949)3.06966204
47maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.04502867
48maturation of 5.8S rRNA (GO:0000460)3.03574507
49resolution of meiotic recombination intermediates (GO:0000712)3.03314708
50negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.01535186
51protein prenylation (GO:0018342)3.00013257
52prenylation (GO:0097354)3.00013257
53negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.99884924
54kinetochore assembly (GO:0051382)2.99644844
55IMP metabolic process (GO:0046040)2.99050713
56chondrocyte development (GO:0002063)2.98931602
57establishment of viral latency (GO:0019043)2.98617439
58ER overload response (GO:0006983)2.98148711
59collagen fibril organization (GO:0030199)2.97001548
60mitotic nuclear envelope disassembly (GO:0007077)2.93862265
61RNA methylation (GO:0001510)2.93467139
62response to X-ray (GO:0010165)2.93296470
63protein K6-linked ubiquitination (GO:0085020)2.91635147
64regulation of centrosome duplication (GO:0010824)2.91178168
65negative regulation of signal transduction by p53 class mediator (GO:1901797)2.90018230
66protein retention in ER lumen (GO:0006621)2.89157896
67regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.88106786
68somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.87594101
69somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.87594101
70isotype switching (GO:0045190)2.87594101
71DNA damage response, detection of DNA damage (GO:0042769)2.86963475
72negative regulation of DNA-dependent DNA replication (GO:2000104)2.86520088
73folic acid-containing compound biosynthetic process (GO:0009396)2.86455095
74transcription-coupled nucleotide-excision repair (GO:0006283)2.85469785
75pore complex assembly (GO:0046931)2.85186002
76regulation of cellular senescence (GO:2000772)2.85167295
77spliceosomal complex assembly (GO:0000245)2.84548289
78regulation of telomere maintenance via telomerase (GO:0032210)2.84211026
79DNA double-strand break processing (GO:0000729)2.83544052
80positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.83307043
81G1/S transition of mitotic cell cycle (GO:0000082)2.82577280
82cell cycle G1/S phase transition (GO:0044843)2.82577280
83deoxyribose phosphate biosynthetic process (GO:0046385)2.81064465
842-deoxyribonucleotide biosynthetic process (GO:0009265)2.81064465
85middle ear morphogenesis (GO:0042474)2.80282800
86membrane disassembly (GO:0030397)2.78271335
87nuclear envelope disassembly (GO:0051081)2.78271335
88anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.78061895
89regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.77715139
90ATP-dependent chromatin remodeling (GO:0043044)2.77541428
91sister chromatid segregation (GO:0000819)2.77178312
92negative regulation of ligase activity (GO:0051352)2.77040297
93negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.77040297
94metanephric mesenchyme development (GO:0072075)2.77012578
95necroptotic process (GO:0070266)2.75812835
96positive regulation of transcription regulatory region DNA binding (GO:2000679)2.75351910
97signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.74787384
98signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.74787384
99signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.74787384
100DNA ligation (GO:0006266)2.73940252
101de novo protein folding (GO:0006458)2.72729108
102viral mRNA export from host cell nucleus (GO:0046784)2.72255816
103DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.72005439
104regulation of cytokine secretion involved in immune response (GO:0002739)2.71773306
105negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.71479472
106negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.70575301
107signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.70265855
108intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.70265855
109mitotic spindle assembly checkpoint (GO:0007094)2.69876803
110DNA catabolic process, exonucleolytic (GO:0000738)2.69448287
111eosinophil migration (GO:0072677)2.69418334
112negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.68521573
113microtubule depolymerization (GO:0007019)2.68304210
114regulation of mitotic spindle checkpoint (GO:1903504)2.67625590
115regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.67625590
116regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.67457788
117regulation of mitotic metaphase/anaphase transition (GO:0030071)2.67457788
118negative regulation of sister chromatid segregation (GO:0033046)2.67134574
119negative regulation of mitotic sister chromatid separation (GO:2000816)2.67134574
120negative regulation of mitotic sister chromatid segregation (GO:0033048)2.67134574
121negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.67134574
122spindle assembly checkpoint (GO:0071173)2.67118503
123RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.66672525
124peptidyl-arginine N-methylation (GO:0035246)2.66317137
125peptidyl-arginine methylation (GO:0018216)2.66317137
126mitotic spindle checkpoint (GO:0071174)2.66048004
127signal transduction involved in DNA damage checkpoint (GO:0072422)2.65845853
128signal transduction involved in DNA integrity checkpoint (GO:0072401)2.65845853
129regulation of chromosome segregation (GO:0051983)2.65757614
130establishment of chromosome localization (GO:0051303)2.65498921
131chondrocyte proliferation (GO:0035988)2.65487566
132pericardium development (GO:0060039)2.65400694
133centriole replication (GO:0007099)2.64719167
134postreplication repair (GO:0006301)2.64426015
135glucocorticoid receptor signaling pathway (GO:0042921)2.64097094
136NIK/NF-kappaB signaling (GO:0038061)2.62116904
137de novo posttranslational protein folding (GO:0051084)2.61403337
138spindle checkpoint (GO:0031577)2.60117601
139telomere maintenance (GO:0000723)2.59844960
140regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.59621214
141outer ear morphogenesis (GO:0042473)2.59316256
142positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.58934456
143negative regulation of chromosome segregation (GO:0051985)2.57875536
144RNA-dependent DNA replication (GO:0006278)2.57439631
145signal transduction involved in cell cycle checkpoint (GO:0072395)2.57268391
146nucleotide-sugar biosynthetic process (GO:0009226)2.55855600
147protein localization to chromosome, centromeric region (GO:0071459)2.55055190
148regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)2.54830041
149response to redox state (GO:0051775)2.53918658
150regulation of sister chromatid segregation (GO:0033045)2.53884089
151regulation of mitotic sister chromatid separation (GO:0010965)2.53884089
152regulation of mitotic sister chromatid segregation (GO:0033047)2.53884089
153UDP-N-acetylglucosamine metabolic process (GO:0006047)2.52873036
154regulation of vitamin D biosynthetic process (GO:0060556)2.52506277
155regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.45191164
156single strand break repair (GO:0000012)2.42393374
157non-recombinational repair (GO:0000726)2.42292356
158double-strand break repair via nonhomologous end joining (GO:0006303)2.42292356
159negative regulation of DNA repair (GO:0045738)2.40755115
160mitotic sister chromatid segregation (GO:0000070)2.40587362
161cellular response to dsRNA (GO:0071359)2.40559942
162anterior/posterior axis specification, embryo (GO:0008595)2.39626363

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.08847950
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.17211124
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.13445812
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.56459359
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.55906757
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.42822458
7RBPJ_22232070_ChIP-Seq_NCS_Mouse3.15468480
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.15255688
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.05592822
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.05389773
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.00589813
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.97186633
13ELK1_19687146_ChIP-ChIP_HELA_Human2.75806016
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.74955480
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.71217886
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69494179
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.68041312
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.66020396
19PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.64048651
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.60771062
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.57315347
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.55668893
23AR_21909140_ChIP-Seq_LNCAP_Human2.51498803
24* DCP1A_22483619_ChIP-Seq_HELA_Human2.46524735
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.44857723
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.38725036
27MYC_19079543_ChIP-ChIP_MESCs_Mouse2.38359267
28KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.29401594
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.23743623
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.21433726
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.21055856
32XRN2_22483619_ChIP-Seq_HELA_Human2.16398555
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.16066461
34NOTCH1_21737748_ChIP-Seq_TLL_Human2.12368277
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.05172467
36TRIM28_21343339_ChIP-Seq_HEK293_Human2.04911483
37VDR_23849224_ChIP-Seq_CD4+_Human2.02542950
38E2F1_21310950_ChIP-Seq_MCF-7_Human2.00979150
39* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.00446921
40MYCN_18555785_ChIP-Seq_MESCs_Mouse2.00237099
41GABP_19822575_ChIP-Seq_HepG2_Human1.95271952
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.92119403
43FOXP3_21729870_ChIP-Seq_TREG_Human1.90695336
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.90623704
45ZNF274_21170338_ChIP-Seq_K562_Hela1.88818093
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88517925
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88030534
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.84631044
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81755751
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79986545
51TTF2_22483619_ChIP-Seq_HELA_Human1.79971678
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.79796953
53SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.76929775
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.73144838
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.70706323
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68037042
57* EZH2_27294783_Chip-Seq_NPCs_Mouse1.62704495
58TFEB_21752829_ChIP-Seq_HELA_Human1.58564933
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58469893
60* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.58045534
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54067281
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52498922
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.49534933
64* NFE2_27457419_Chip-Seq_LIVER_Mouse1.48154539
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45050783
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.43895741
67GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43717879
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43268406
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.42343661
70EWS_26573619_Chip-Seq_HEK293_Human1.41743568
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39980936
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37922399
73SRF_21415370_ChIP-Seq_HL-1_Mouse1.36211185
74WT1_19549856_ChIP-ChIP_CCG9911_Human1.32463696
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32267240
76HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.30679014
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30125845
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29382910
79* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23996534
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21893991
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21310968
82* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19305748
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18028366
84* CRX_20693478_ChIP-Seq_RETINA_Mouse1.17881872
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16896094
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16378126
87* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14939587
88MYC_18940864_ChIP-ChIP_HL60_Human1.14741765
89FUS_26573619_Chip-Seq_HEK293_Human1.12209542
90TAF15_26573619_Chip-Seq_HEK293_Human1.11721749
91* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10125774
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10002080
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09718129
94* NANOG_18555785_Chip-Seq_ESCs_Mouse1.08296008
95ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08243717
96* P300_19829295_ChIP-Seq_ESCs_Human1.07415844
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06768269
98IRF1_19129219_ChIP-ChIP_H3396_Human1.06490467
99* NMYC_18555785_Chip-Seq_ESCs_Mouse1.04882488
100* E2F1_18555785_Chip-Seq_ESCs_Mouse1.04691597
101SOX17_20123909_ChIP-Seq_XEN_Mouse1.04403280
102* P300_18555785_Chip-Seq_ESCs_Mouse1.03831602
103* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03751166
104CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03715322
105STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03549486
106* P53_22387025_ChIP-Seq_ESCs_Mouse1.02654335
107SMAD_19615063_ChIP-ChIP_OVARY_Human1.02329174
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02320667
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01616071
110CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01465477
111FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00656813
112KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00565341
113HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00275903
114* CMYC_18555785_Chip-Seq_ESCs_Mouse0.99933682
115* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99461010
116KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98453111
117KDM5A_27292631_Chip-Seq_BREAST_Human0.97894587
118E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97731538
119NANOG_16153702_ChIP-ChIP_HESCs_Human0.97697532
120SALL1_21062744_ChIP-ChIP_HESCs_Human0.97140737
121GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96358798
122E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95750668
123* SOX2_18555785_Chip-Seq_ESCs_Mouse0.95313425
124* OCT4_18555785_Chip-Seq_ESCs_Mouse0.95059486
125IRF8_22096565_ChIP-ChIP_GC-B_Human0.94886207
126CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94452865
127* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93838253
128NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93623782
129MYB_26560356_Chip-Seq_TH2_Human0.92628595
130* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.92339064
131HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91749492
132SALL4_22934838_ChIP-ChIP_CD34+_Human0.90807447
133* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90336104
134SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88349651
135SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88137297
136MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.87339930
137CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86506538
138BRD4_25478319_ChIP-Seq_HGPS_Human0.85684248
139CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.84575710
140NANOG_18555785_ChIP-Seq_MESCs_Mouse0.81793129
141NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.81262356
142ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80147505
143CIITA_25753668_ChIP-Seq_RAJI_Human0.80064744
144* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.79547544
145SOX2_16153702_ChIP-ChIP_HESCs_Human0.78015384
146NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.76973888

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.90815490
2MP0003950_abnormal_plasma_membrane3.68140772
3MP0003693_abnormal_embryo_hatching3.43213579
4MP0010030_abnormal_orbit_morphology3.19441553
5MP0005503_abnormal_tendon_morphology3.12834703
6MP0003123_paternal_imprinting2.73372050
7MP0003705_abnormal_hypodermis_morpholog2.64747531
8MP0010094_abnormal_chromosome_stability2.63872144
9MP0004957_abnormal_blastocyst_morpholog2.63457462
10MP0008007_abnormal_cellular_replicative2.60173543
11MP0002254_reproductive_system_inflammat2.42560721
12MP0009053_abnormal_anal_canal2.27449956
13MP0009250_abnormal_appendicular_skeleto2.25336503
14MP0003806_abnormal_nucleotide_metabolis2.21296597
15MP0003077_abnormal_cell_cycle2.15189343
16MP0008058_abnormal_DNA_repair2.07225789
17MP0004134_abnormal_chest_morphology2.06768241
18MP0000049_abnormal_middle_ear2.04464738
19MP0002102_abnormal_ear_morphology2.01856715
20MP0003111_abnormal_nucleus_morphology2.01447064
21MP0008789_abnormal_olfactory_epithelium1.99980957
22MP0002282_abnormal_trachea_morphology1.97115077
23MP0006292_abnormal_olfactory_placode1.88718049
24MP0009384_cardiac_valve_regurgitation1.86855216
25MP0003121_genomic_imprinting1.80556548
26MP0001853_heart_inflammation1.80020173
27MP0008877_abnormal_DNA_methylation1.78119973
28MP0003937_abnormal_limbs/digits/tail_de1.75952788
29MP0003755_abnormal_palate_morphology1.74870451
30MP0001542_abnormal_bone_strength1.74606333
31MP0003385_abnormal_body_wall1.73438638
32MP0010352_gastrointestinal_tract_polyps1.73288006
33MP0006054_spinal_hemorrhage1.69559647
34MP0005275_abnormal_skin_tensile1.67842704
35MP0008932_abnormal_embryonic_tissue1.66266539
36MP0002233_abnormal_nose_morphology1.63918770
37MP0003122_maternal_imprinting1.57853794
38MP0000428_abnormal_craniofacial_morphol1.55252556
39MP0003279_aneurysm1.53708927
40MP0002115_abnormal_skeleton_extremities1.53701618
41MP0000350_abnormal_cell_proliferation1.52054254
42MP0003942_abnormal_urinary_system1.49189505
43MP0005671_abnormal_response_to1.48818776
44MP0003718_maternal_effect1.46098261
45MP0000163_abnormal_cartilage_morphology1.45845410
46MP0002896_abnormal_bone_mineralization1.44722024
47MP0002113_abnormal_skeleton_development1.43175693
48MP0002138_abnormal_hepatobiliary_system1.42137177
49MP0005076_abnormal_cell_differentiation1.39930530
50MP0005508_abnormal_skeleton_morphology1.39704392
51MP0002933_joint_inflammation1.39080485
52MP0000569_abnormal_digit_pigmentation1.39067392
53MP0002109_abnormal_limb_morphology1.37984250
54MP0002148_abnormal_hypersensitivity_rea1.37322889
55MP0002938_white_spotting1.36640597
56MP0009697_abnormal_copulation1.36045191
57MP0003186_abnormal_redox_activity1.35785715
58MP0001764_abnormal_homeostasis1.33369817
59MP0002177_abnormal_outer_ear1.28987725
60MP0004272_abnormal_basement_membrane1.27473546
61MP0010307_abnormal_tumor_latency1.26901185
62MP0004808_abnormal_hematopoietic_stem1.26792857
63MP0005023_abnormal_wound_healing1.26180706
64MP0000383_abnormal_hair_follicle1.24945730
65MP0005310_abnormal_salivary_gland1.23169134
66MP0002111_abnormal_tail_morphology1.21701809
67MP0004197_abnormal_fetal_growth/weight/1.21620221
68MP0003119_abnormal_digestive_system1.21266840
69MP0005000_abnormal_immune_tolerance1.20694861
70MP0001730_embryonic_growth_arrest1.19611088
71MP0001243_abnormal_dermal_layer1.17753827
72MP0001293_anophthalmia1.17752973
73MP0003828_pulmonary_edema1.17676967
74MP0001835_abnormal_antigen_presentation1.17191601
75MP0002116_abnormal_craniofacial_bone1.16239294
76MP0003448_altered_tumor_morphology1.16131183
77MP0001119_abnormal_female_reproductive1.15961544
78MP0002019_abnormal_tumor_incidence1.12853118
79MP0002751_abnormal_autonomic_nervous1.12250248
80MP0001697_abnormal_embryo_size1.12047853
81MP0001299_abnormal_eye_distance/1.10370574
82MP0005645_abnormal_hypothalamus_physiol1.07381170
83MP0000013_abnormal_adipose_tissue1.06090307
84MP0000631_abnormal_neuroendocrine_gland1.04829231
85MP0005499_abnormal_olfactory_system1.04348001
86MP0005394_taste/olfaction_phenotype1.04348001
87MP0003656_abnormal_erythrocyte_physiolo1.03389131
88MP0001324_abnormal_eye_pigmentation1.02651869
89MP0002060_abnormal_skin_morphology1.02489038
90MP0002295_abnormal_pulmonary_circulatio1.00843417
91MP0000372_irregular_coat_pigmentation1.00673771
92MP0000613_abnormal_salivary_gland0.99967001
93MP0000432_abnormal_head_morphology0.99603092
94MP0002085_abnormal_embryonic_tissue0.99563602
95MP0002932_abnormal_joint_morphology0.99159369
96MP0002163_abnormal_gland_morphology0.98728483
97MP0005367_renal/urinary_system_phenotyp0.98507625
98MP0000516_abnormal_urinary_system0.98507625
99MP0002114_abnormal_axial_skeleton0.97097031
100MP0009785_altered_susceptibility_to0.96878014
101MP0002452_abnormal_antigen_presenting0.96309624
102MP0003091_abnormal_cell_migration0.96298018
103MP0003935_abnormal_craniofacial_develop0.95865568
104MP0000762_abnormal_tongue_morphology0.94906034
105MP0003115_abnormal_respiratory_system0.94356404
106MP0001800_abnormal_humoral_immune0.93841519
107MP0005257_abnormal_intraocular_pressure0.93514326
108MP0004133_heterotaxia0.93476387
109MP0006072_abnormal_retinal_apoptosis0.93382619
110MP0002084_abnormal_developmental_patter0.93007284
111MP0003763_abnormal_thymus_physiology0.91974339
112MP0001672_abnormal_embryogenesis/_devel0.91525700
113MP0005380_embryogenesis_phenotype0.91525700
114MP0000678_abnormal_parathyroid_gland0.90921698
115MP0003786_premature_aging0.90640268
116MP0001346_abnormal_lacrimal_gland0.90610462
117MP0003984_embryonic_growth_retardation0.89799085
118MP0003941_abnormal_skin_development0.89524635
119MP0002088_abnormal_embryonic_growth/wei0.88948190
120MP0003795_abnormal_bone_structure0.88570998
121MP0003938_abnormal_ear_development0.88495490
122MP0003787_abnormal_imprinting0.88405355
123MP0002080_prenatal_lethality0.88094315
124MP0005390_skeleton_phenotype0.88015170
125MP0001873_stomach_inflammation0.87366941
126MP0008057_abnormal_DNA_replication0.87182089
127MP0005253_abnormal_eye_physiology0.87141091
128MP0000566_synostosis0.85554590
129MP0009764_decreased_sensitivity_to0.85001160
130MP0000689_abnormal_spleen_morphology0.84721933
131MP0005395_other_phenotype0.84711568
132MP0002722_abnormal_immune_system0.84497746
133MP0002405_respiratory_system_inflammati0.83236381
134MP0008873_increased_physiological_sensi0.81493443
135MP0003890_abnormal_embryonic-extraembry0.81320118
136MP0004264_abnormal_extraembryonic_tissu0.80211620
137MP0002723_abnormal_immune_serum0.79618219
138MP0000647_abnormal_sebaceous_gland0.79285233
139MP0005174_abnormal_tail_pigmentation0.78522616
140MP0005164_abnormal_response_to0.78220756
141MP0005197_abnormal_uvea_morphology0.78179934
142MP0002210_abnormal_sex_determination0.78087013
143MP0002006_tumorigenesis0.77424831
144MP0001849_ear_inflammation0.77394873
145MP0003724_increased_susceptibility_to0.76280965
146MP0002396_abnormal_hematopoietic_system0.76113802
147MP0002139_abnormal_hepatobiliary_system0.75994483
148MP0010678_abnormal_skin_adnexa0.75945864
149MP0000358_abnormal_cell_content/0.75873555
150MP0000427_abnormal_hair_cycle0.75336844
151MP0002398_abnormal_bone_marrow0.75088293
152MP0002089_abnormal_postnatal_growth/wei0.74788242
153MP0001286_abnormal_eye_development0.73846981
154MP0003221_abnormal_cardiomyocyte_apopto0.73638968
155MP0001845_abnormal_inflammatory_respons0.73344002
156MP0000703_abnormal_thymus_morphology0.72961389
157MP0000313_abnormal_cell_death0.72416788
158MP0002086_abnormal_extraembryonic_tissu0.70684121
159MP0001929_abnormal_gametogenesis0.70425899
160MP0004084_abnormal_cardiac_muscle0.70085963
161MP0005376_homeostasis/metabolism_phenot0.67613540
162MP0000653_abnormal_sex_gland0.67511099
163MP0001177_atelectasis0.67498289
164MP0001191_abnormal_skin_condition0.66061196

Predicted human phenotypes

RankGene SetZ-score
1Irregular epiphyses (HP:0010582)4.97302729
2Epiphyseal dysplasia (HP:0002656)4.82571285
3Vitreoretinal degeneration (HP:0000655)4.38054831
4Prostate neoplasm (HP:0100787)4.36144997
5Mild short stature (HP:0003502)3.88457849
6Cupped ribs (HP:0000887)3.87042643
7Metaphyseal cupping (HP:0003021)3.75791427
8Protrusio acetabuli (HP:0003179)3.75719737
9Small epiphyses (HP:0010585)3.62858530
10Nephroblastoma (Wilms tumor) (HP:0002667)3.59013074
11Volvulus (HP:0002580)3.54743627
12Premature rupture of membranes (HP:0001788)3.48008354
13Embryonal renal neoplasm (HP:0011794)3.44848214
14Intestinal atresia (HP:0011100)3.43686519
15Hypoplastic ischia (HP:0003175)3.33426143
16Neonatal short-limb short stature (HP:0008921)3.31635009
17Colon cancer (HP:0003003)3.27693805
18Spinal cord compression (HP:0002176)3.18291171
19Congenital primary aphakia (HP:0007707)3.10289360
20Cervical subluxation (HP:0003308)3.06991241
21Delayed epiphyseal ossification (HP:0002663)3.03651342
22Abnormality of the ischium (HP:0003174)3.03221577
23Abnormality of dentin (HP:0010299)3.01146782
24Medial flaring of the eyebrow (HP:0010747)3.00017883
25Overlapping toe (HP:0001845)2.99703067
263-Methylglutaconic aciduria (HP:0003535)2.95429914
27Type I transferrin isoform profile (HP:0003642)2.91321327
28Genu varum (HP:0002970)2.90742756
29Glossoptosis (HP:0000162)2.87851985
30Flat capital femoral epiphysis (HP:0003370)2.85666065
31Carpal bone hypoplasia (HP:0001498)2.82071807
32Abnormality of the proximal phalanges of the hand (HP:0009834)2.79644988
33Abnormal protein glycosylation (HP:0012346)2.79440668
34Abnormal glycosylation (HP:0012345)2.79440668
35Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.79440668
36Abnormal protein N-linked glycosylation (HP:0012347)2.79440668
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.75523754
38Ankle contracture (HP:0006466)2.74926879
39Abnormal foot bone ossification (HP:0010675)2.73964768
40Hyperglycinemia (HP:0002154)2.73786138
41Chromsome breakage (HP:0040012)2.72708813
42Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.70661839
43Short 4th metacarpal (HP:0010044)2.70661839
44Gait imbalance (HP:0002141)2.70169864
45Mesomelia (HP:0003027)2.65574883
46Stomach cancer (HP:0012126)2.63238322
47Genital tract atresia (HP:0001827)2.53164542
48Metaphyseal dysplasia (HP:0100255)2.48314848
49Poor coordination (HP:0002370)2.45114160
50Abnormal tarsal ossification (HP:0008369)2.43976403
51Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.42981881
52Reduced antithrombin III activity (HP:0001976)2.42361572
53Vaginal atresia (HP:0000148)2.42063258
54Abnormality of the acetabulum (HP:0003170)2.39394196
55Abnormal lung lobation (HP:0002101)2.39393748
56Neoplasm of the colon (HP:0100273)2.38956540
57* Platyspondyly (HP:0000926)2.37707988
58Absent epiphyses (HP:0010577)2.37378466
59Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.37378466
60Abnormality of methionine metabolism (HP:0010901)2.34160252
6111 pairs of ribs (HP:0000878)2.32989903
62Abnormality of the prostate (HP:0008775)2.31268684
63Soft skin (HP:0000977)2.29820656
64Abnormality of the pons (HP:0007361)2.29422255
65Abnormality of the phalanges of the hallux (HP:0010057)2.26455388
66Small hand (HP:0200055)2.26140718
67Degeneration of anterior horn cells (HP:0002398)2.25584957
68Abnormality of the anterior horn cell (HP:0006802)2.25584957
69Myelodysplasia (HP:0002863)2.25212117
70Aplasia/Hypoplasia of the patella (HP:0006498)2.24202390
71Flattened epiphyses (HP:0003071)2.24096619
72Abnormality of the nasal septum (HP:0000419)2.22339547
73Broad long bones (HP:0005622)2.21306933
74Patellar aplasia (HP:0006443)2.19791137
75Abnormality of the vertebral endplates (HP:0005106)2.19656551
76Flat acetabular roof (HP:0003180)2.19067037
77Irregular vertebral endplates (HP:0003301)2.18222455
78Selective tooth agenesis (HP:0001592)2.18215731
79Abnormality of the duodenum (HP:0002246)2.17927741
80Abnormal vertebral ossification (HP:0100569)2.16915449
81Tubulointerstitial nephritis (HP:0001970)2.16014291
82* Wormian bones (HP:0002645)2.15956565
83Abnormality of femoral epiphyses (HP:0006499)2.15248394
84Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.15248394
85Fibular hypoplasia (HP:0003038)2.15177056
86Hypoplastic pelvis (HP:0008839)2.13531968
87Broad phalanx (HP:0006009)2.13238286
88Natal tooth (HP:0000695)2.12291554
89Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.12135503
90Vertebral hypoplasia (HP:0008417)2.12135503
91Pancytopenia (HP:0001876)2.11956353
92Stillbirth (HP:0003826)2.11845582
93Facial cleft (HP:0002006)2.10095254
94Sloping forehead (HP:0000340)2.08844442
95Abnormality of serum amino acid levels (HP:0003112)2.08510379
96Slender build (HP:0001533)2.07653446
97Long clavicles (HP:0000890)2.06821198
98* Beaking of vertebral bodies (HP:0004568)2.06557228
99Small intestinal stenosis (HP:0012848)2.06483988
100Duodenal stenosis (HP:0100867)2.06483988
101Osteoarthritis (HP:0002758)2.05872158
102Facial hemangioma (HP:0000329)2.05144135
103Abnormality of the preputium (HP:0100587)2.02795136
104Medulloblastoma (HP:0002885)2.02180014
105Abnormality of the calcaneus (HP:0008364)2.00522900
106Coxa vara (HP:0002812)2.00071284
107Abnormality of aspartate family amino acid metabolism (HP:0010899)1.97409026
108Median cleft lip (HP:0000161)1.95220716
109Shallow orbits (HP:0000586)1.94388328
110Rough bone trabeculation (HP:0100670)1.93903680
111IgG deficiency (HP:0004315)1.93650988
112Rectovaginal fistula (HP:0000143)1.92942547
113Rectal fistula (HP:0100590)1.92942547
114Abnormality of the intervertebral disk (HP:0005108)1.92569946
115Abnormality of the epiphysis of the femoral head (HP:0010574)1.90892652
116Thin ribs (HP:0000883)1.90671140
117* Biconcave vertebral bodies (HP:0004586)1.89620415
118Radial bowing (HP:0002986)1.89108311
119Abnormality of the phalanges of the 2nd finger (HP:0009541)1.88092391
120Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.87560140
121Broad foot (HP:0001769)1.87548678
122Broad phalanges of the hand (HP:0009768)1.86580061
123Short femoral neck (HP:0100864)1.86154080
124Nephrogenic diabetes insipidus (HP:0009806)1.85520033
125* Vertebral compression fractures (HP:0002953)1.85018867
126Rhabdomyosarcoma (HP:0002859)1.84790661
127Entropion (HP:0000621)1.84776995
128Short ribs (HP:0000773)1.84302992
129Rhizomelia (HP:0008905)1.84088644
130Wrist flexion contracture (HP:0001239)1.83961720
131Abnormality of chromosome stability (HP:0003220)1.83483407
132Meckel diverticulum (HP:0002245)1.83394812
133Spinal muscular atrophy (HP:0007269)1.82920634
134Aplasia/Hypoplasia of the fibula (HP:0006492)1.82562086
135Broad thumb (HP:0011304)1.82549378
136Patent foramen ovale (HP:0001655)1.81698643
137Hypoplasia of the pons (HP:0012110)1.81260459
138Papillary thyroid carcinoma (HP:0002895)1.79313008
139Oral leukoplakia (HP:0002745)1.77942273
140Poor head control (HP:0002421)1.77913820
141Abnormality of DNA repair (HP:0003254)1.77619801
142Short 5th finger (HP:0009237)1.77233027
143Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.77062969
144Abnormality of the labia minora (HP:0012880)1.77056713
145IgM deficiency (HP:0002850)1.76949735
146IgA deficiency (HP:0002720)1.76679483
147Abnormality of male internal genitalia (HP:0000022)1.74164778
148Metaphyseal irregularity (HP:0003025)1.73081440
149Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.72953492
150Deep philtrum (HP:0002002)1.72547306
151Broad finger (HP:0001500)1.72390146
152Micromelia (HP:0002983)1.72107658
153Aplasia/Hypoplasia of the lens (HP:0008063)1.71484426
154Thin upper lip vermilion (HP:0000219)1.71287437
155Oligodactyly (hands) (HP:0001180)1.71213013
156Dilatation of the ascending aorta (HP:0005111)1.70231531
157Abnormality of the femoral head (HP:0003368)1.69947855
158Arthropathy (HP:0003040)1.69596141
159Increased hepatocellular lipid droplets (HP:0006565)1.69502190
160Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.69311982
161Abnormality of the ileum (HP:0001549)1.69210239
162Aplasia/Hypoplasia of the uvula (HP:0010293)1.69187919
163Abnormal hair whorl (HP:0010721)1.68824844
164Syringomyelia (HP:0003396)1.68654326
165Spinal cord lesions (HP:0100561)1.68654326
166Postaxial foot polydactyly (HP:0001830)1.67138599
167Gastrointestinal atresia (HP:0002589)1.66396538
168Basal cell carcinoma (HP:0002671)1.65715573
169Abnormality of glycolipid metabolism (HP:0010969)1.65696963
170Abnormality of liposaccharide metabolism (HP:0010968)1.65696963
171Abnormality of glycosphingolipid metabolism (HP:0004343)1.65696963
172Acute myeloid leukemia (HP:0004808)1.65432022
173Decreased testicular size (HP:0008734)1.64904493
174Methylmalonic acidemia (HP:0002912)1.64077818
175Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.63404009
176Pancreatic cysts (HP:0001737)1.62147162
177Ascites (HP:0001541)1.61632851
178Wide nose (HP:0000445)1.60686235
179Bifid tongue (HP:0010297)1.60489125
180Abnormality of lateral ventricle (HP:0030047)1.59293999
181Short middle phalanx of the 5th finger (HP:0004220)1.57448801
182Intrahepatic cholestasis (HP:0001406)1.57041488
183Abnormality of the phalanges of the 5th finger (HP:0004213)1.56243208
184Short foot (HP:0001773)1.55941023
185Increased number of teeth (HP:0011069)1.55364451
186Combined immunodeficiency (HP:0005387)1.53885589
187Postaxial hand polydactyly (HP:0001162)1.53220376
188Abnormality of B cell number (HP:0010975)1.51066850
189Spondylolisthesis (HP:0003302)1.50971077
190Dental crowding (HP:0000678)1.50561081
191Microvesicular hepatic steatosis (HP:0001414)1.49771588
192Poikiloderma (HP:0001029)1.49745024

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRSK24.58634861
2BUB14.26587802
3CDC73.81827972
4TRIM283.36110843
5MAP4K23.01659792
6WEE12.82114971
7ERBB32.81832220
8TAOK32.74595153
9VRK22.71512855
10BRSK12.70941680
11SIK32.69657316
12DDR22.63721833
13PLK42.51873494
14PLK32.31988441
15LATS12.29189268
16MKNK12.21881879
17EIF2AK12.14061714
18ACVR1B2.12930125
19RPS6KA42.10933105
20CCNB12.08240023
21WNK32.05852755
22NUAK12.02804699
23NME11.98027539
24PDK21.85697616
25SRPK11.81335600
26EIF2AK31.71827863
27MKNK21.64840851
28NME21.62567267
29NEK21.57704430
30PLK11.54455316
31TGFBR11.52388340
32CDK81.49941355
33TSSK61.47248925
34PASK1.46858450
35ADRBK21.41504977
36LIMK11.39762820
37ZAK1.38997722
38MAP3K31.37515730
39PLK21.37239589
40GRK71.36198688
41TAF11.35327275
42MAP3K141.31057180
43MOS1.29062133
44NEK11.27550549
45VRK11.26834289
46RPS6KB21.24693791
47TNIK1.16773568
48AKT31.14868313
49BMPR1B1.14388654
50AURKA1.13848950
51AURKB1.08922663
52TESK11.08773194
53MELK1.05318966
54PRKG21.00706818
55CAMKK20.99859405
56CLK10.98284434
57ATR0.97696872
58NLK0.94421126
59TXK0.93306188
60STK30.93142218
61PBK0.92679188
62CDK90.88713023
63BCR0.85463849
64PAK20.85442530
65YES10.85148655
66MST40.84645054
67CSNK1G30.81105632
68STK38L0.80377725
69ERBB40.79971967
70SCYL20.79648392
71TTK0.79193780
72TRPM70.77792375
73CSNK1G10.76860159
74TGFBR20.75998024
75PNCK0.74654311
76CDK180.74348780
77CDK140.74084073
78ATM0.72988907
79CDK150.72035806
80EPHB20.71605204
81MAP2K20.70570891
82IKBKB0.70402718
83CDK190.68154388
84PIM20.66703897
85EPHA20.66480653
86FLT30.65637485
87CHEK10.65554502
88CDK11A0.65059899
89CHEK20.63596183
90CSNK2A10.61938419
91IRAK30.60483849
92DYRK20.57832003
93CSNK2A20.55683422
94PAK40.54913255
95PIK3CA0.53653477
96FGFR10.52834823
97NEK90.52270022
98STK240.52233324
99MAP3K120.50448240
100CDK10.49867835
101PAK10.49652647
102EIF2AK20.49224439
103BRD40.48362900
104LATS20.47024453
105CDK20.47010309
106PIK3CG0.44492233
107PAK30.44368443
108CSNK1G20.44174659
109CDK70.44107169
110TLK10.44052556
111ARAF0.43314380
112RPS6KA50.43031046
113BRAF0.40967822
114IKBKE0.40820191
115MARK30.37267282
116CDK30.36506588
117GRK10.36437898
118ABL10.36276997
119CSNK1A1L0.36086149
120PRKCE0.36080772
121DYRK30.35408164
122PIM10.34814202
123MST1R0.34788862
124PRKDC0.34572044
125BMPR20.33191699
126MAP3K80.32651536
127PDGFRA0.32079488
128STK100.31110179
129STK160.30693268
130PRKCQ0.29993285
131CHUK0.29967553
132UHMK10.29891034
133TBK10.29793217
134MYLK0.29270693
135CDK60.28540237
136MAP2K10.24663260
137TTN0.24440467
138TAOK20.23979214
139PKN20.23320364
140CDK40.23000786
141AKT10.22891704
142RPS6KB10.22765329
143DYRK1B0.22553221
144MUSK0.22454164

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.21742443
2Mismatch repair_Homo sapiens_hsa034303.58203910
3Proteasome_Homo sapiens_hsa030503.48501261
4Protein export_Homo sapiens_hsa030603.18069179
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.04156500
6Nucleotide excision repair_Homo sapiens_hsa034202.92991987
7Spliceosome_Homo sapiens_hsa030402.82453628
8Cell cycle_Homo sapiens_hsa041102.80813903
9RNA transport_Homo sapiens_hsa030132.73935792
10Base excision repair_Homo sapiens_hsa034102.57507042
11RNA polymerase_Homo sapiens_hsa030202.56648470
12Non-homologous end-joining_Homo sapiens_hsa034502.45951184
13One carbon pool by folate_Homo sapiens_hsa006702.41969515
14Homologous recombination_Homo sapiens_hsa034402.36555201
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.34535966
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.19493603
17Ribosome_Homo sapiens_hsa030102.16471084
18Pyrimidine metabolism_Homo sapiens_hsa002401.94030488
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.78351847
20Fanconi anemia pathway_Homo sapiens_hsa034601.72305418
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.72091384
22RNA degradation_Homo sapiens_hsa030181.66689997
23Folate biosynthesis_Homo sapiens_hsa007901.66612436
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.65297851
25Basal transcription factors_Homo sapiens_hsa030221.61438390
26Asthma_Homo sapiens_hsa053101.56486151
27* p53 signaling pathway_Homo sapiens_hsa041151.46520681
28N-Glycan biosynthesis_Homo sapiens_hsa005101.37168516
29mRNA surveillance pathway_Homo sapiens_hsa030151.35431407
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35066847
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.34685997
32Butanoate metabolism_Homo sapiens_hsa006501.34546207
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.28232715
34Vibrio cholerae infection_Homo sapiens_hsa051101.26859146
35Propanoate metabolism_Homo sapiens_hsa006401.26822776
36ECM-receptor interaction_Homo sapiens_hsa045121.24963196
37Epstein-Barr virus infection_Homo sapiens_hsa051691.23384526
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.19546243
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.13032370
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10774238
41Parkinsons disease_Homo sapiens_hsa050121.10645562
42Huntingtons disease_Homo sapiens_hsa050161.10146974
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09791578
44Oxidative phosphorylation_Homo sapiens_hsa001901.09752705
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07936160
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07328493
47TGF-beta signaling pathway_Homo sapiens_hsa043501.06505153
48Purine metabolism_Homo sapiens_hsa002301.06340336
49Systemic lupus erythematosus_Homo sapiens_hsa053221.05988027
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05022325
51Measles_Homo sapiens_hsa051621.02160542
52Circadian rhythm_Homo sapiens_hsa047101.01728643
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98079069
54Legionellosis_Homo sapiens_hsa051340.96141352
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89658389
56Protein digestion and absorption_Homo sapiens_hsa049740.89176149
57Fatty acid elongation_Homo sapiens_hsa000620.88734346
58Primary immunodeficiency_Homo sapiens_hsa053400.80541754
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78524337
60Oocyte meiosis_Homo sapiens_hsa041140.77002310
61Viral carcinogenesis_Homo sapiens_hsa052030.76033357
62Allograft rejection_Homo sapiens_hsa053300.76027519
63Phagosome_Homo sapiens_hsa041450.75045424
64HTLV-I infection_Homo sapiens_hsa051660.74301409
65Hippo signaling pathway_Homo sapiens_hsa043900.72882690
66Alcoholism_Homo sapiens_hsa050340.72875004
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70161322
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.68651895
69Sulfur metabolism_Homo sapiens_hsa009200.67720381
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67715237
71TNF signaling pathway_Homo sapiens_hsa046680.67664014
72Other glycan degradation_Homo sapiens_hsa005110.66616193
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.65777833
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65546108
75Herpes simplex infection_Homo sapiens_hsa051680.65071299
76Alzheimers disease_Homo sapiens_hsa050100.63181606
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63139062
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59797670
79MicroRNAs in cancer_Homo sapiens_hsa052060.59320273
80Hepatitis B_Homo sapiens_hsa051610.59251807
81Regulation of autophagy_Homo sapiens_hsa041400.58908779
82Type I diabetes mellitus_Homo sapiens_hsa049400.58075733
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56083158
84Pyruvate metabolism_Homo sapiens_hsa006200.54949493
85PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54369564
86Hedgehog signaling pathway_Homo sapiens_hsa043400.53846163
87Focal adhesion_Homo sapiens_hsa045100.53554135
88Shigellosis_Homo sapiens_hsa051310.52047683
89Nitrogen metabolism_Homo sapiens_hsa009100.50626215
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49145211
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.48941704
92Glutathione metabolism_Homo sapiens_hsa004800.48371838
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.47014998
94Autoimmune thyroid disease_Homo sapiens_hsa053200.44586135
95Tryptophan metabolism_Homo sapiens_hsa003800.43743388
96Lysosome_Homo sapiens_hsa041420.43459698
97Sphingolipid metabolism_Homo sapiens_hsa006000.42657830
98Proteoglycans in cancer_Homo sapiens_hsa052050.40613285
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40350047
100T cell receptor signaling pathway_Homo sapiens_hsa046600.39515509
101Pertussis_Homo sapiens_hsa051330.39055631
102Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38818902
103Adherens junction_Homo sapiens_hsa045200.37944348
104African trypanosomiasis_Homo sapiens_hsa051430.37698683
105Steroid biosynthesis_Homo sapiens_hsa001000.37606455
106Toxoplasmosis_Homo sapiens_hsa051450.36856237
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35941789
108Peroxisome_Homo sapiens_hsa041460.35078899
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34546913
110Thyroid cancer_Homo sapiens_hsa052160.33698775
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32313873
112Basal cell carcinoma_Homo sapiens_hsa052170.31737330
113Galactose metabolism_Homo sapiens_hsa000520.30940047
114HIF-1 signaling pathway_Homo sapiens_hsa040660.30129237
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.29553488
116Small cell lung cancer_Homo sapiens_hsa052220.29552389
117Biosynthesis of amino acids_Homo sapiens_hsa012300.29309238
118Melanoma_Homo sapiens_hsa052180.27513453
119Antigen processing and presentation_Homo sapiens_hsa046120.27169988
120Rheumatoid arthritis_Homo sapiens_hsa053230.26901661
121Apoptosis_Homo sapiens_hsa042100.26452378
122Selenocompound metabolism_Homo sapiens_hsa004500.26166875
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23350880
124Malaria_Homo sapiens_hsa051440.23182774
125Prostate cancer_Homo sapiens_hsa052150.21550681
126Sulfur relay system_Homo sapiens_hsa041220.21237524
127Collecting duct acid secretion_Homo sapiens_hsa049660.21121570
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21079728
129Bladder cancer_Homo sapiens_hsa052190.20715443
130Wnt signaling pathway_Homo sapiens_hsa043100.20430594
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19612872
132Colorectal cancer_Homo sapiens_hsa052100.19457072
133Influenza A_Homo sapiens_hsa051640.18162972
134Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.17700627
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.14786210
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.14098835
137Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.13818363
138Arachidonic acid metabolism_Homo sapiens_hsa005900.13410414
139Pathways in cancer_Homo sapiens_hsa052000.12321943

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