GON4L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)7.98867426
2daunorubicin metabolic process (GO:0044597)7.98867426
3polyketide metabolic process (GO:0030638)7.98867426
4protein localization to kinetochore (GO:0034501)6.17811894
5negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.72410547
6maintenance of protein location in nucleus (GO:0051457)5.69039847
7histone H4-K8 acetylation (GO:0043982)5.63325923
8histone H4-K5 acetylation (GO:0043981)5.63325923
9histone H4-K12 acetylation (GO:0043983)5.55539284
10nuclear pore complex assembly (GO:0051292)5.51659862
11regulation of telomere maintenance via telomerase (GO:0032210)5.46794331
12regulation of nuclear cell cycle DNA replication (GO:0033262)5.27600127
13mitotic sister chromatid segregation (GO:0000070)5.27532206
14pre-miRNA processing (GO:0031054)5.26520565
15membrane repolarization during cardiac muscle cell action potential (GO:0086013)5.23783860
16membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.22746267
17regulation of DNA endoreduplication (GO:0032875)5.22169166
18interkinetic nuclear migration (GO:0022027)5.14267084
19negative regulation of cell cycle G2/M phase transition (GO:1902750)5.13475977
20regulation of mammary gland epithelial cell proliferation (GO:0033599)5.12151808
21heterochromatin organization (GO:0070828)5.05786059
22aminoglycoside antibiotic metabolic process (GO:0030647)4.97295607
23somite rostral/caudal axis specification (GO:0032525)4.93126287
24negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.91458155
25nuclear pore organization (GO:0006999)4.90151807
26negative regulation of telomerase activity (GO:0051974)4.85876044
27negative regulation of epidermis development (GO:0045683)4.81248172
28positive regulation of fatty acid oxidation (GO:0046321)4.79275011
29sister chromatid segregation (GO:0000819)4.78896177
30outer ear morphogenesis (GO:0042473)4.73228691
31regulation of secondary heart field cardioblast proliferation (GO:0003266)4.68932786
32regulation of cardioblast proliferation (GO:0003264)4.68932786
33protein localization to chromosome, centromeric region (GO:0071459)4.64406833
34regulation of response to osmotic stress (GO:0047484)4.60509976
35histone H4-K16 acetylation (GO:0043984)4.59181651
36membrane repolarization during action potential (GO:0086011)4.57454869
37chromatin assembly (GO:0031497)4.47885165
38cellular response to electrical stimulus (GO:0071257)4.44325058
39DNA replication-dependent nucleosome assembly (GO:0006335)4.41526790
40DNA replication-dependent nucleosome organization (GO:0034723)4.41526790
41aorta morphogenesis (GO:0035909)4.40422774
42notochord development (GO:0030903)4.38812221
43regulation of MHC class I biosynthetic process (GO:0045343)4.36904338
44DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.29961129
45rRNA transcription (GO:0009303)4.26045132
46positive regulation of fatty acid beta-oxidation (GO:0032000)4.20485905
47vitamin A metabolic process (GO:0006776)4.16897712
48positive regulation of DNA-dependent DNA replication (GO:2000105)4.10020353
49pore complex assembly (GO:0046931)4.03697096
50muscle organ morphogenesis (GO:0048644)4.02269536
51pharyngeal system development (GO:0060037)3.95712813
52mRNA stabilization (GO:0048255)3.91114556
53RNA stabilization (GO:0043489)3.91114556
54cell proliferation in forebrain (GO:0021846)3.88442847
55negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.85781534
56positive regulation of histone deacetylation (GO:0031065)3.85505437
57DNA damage response, signal transduction resulting in transcription (GO:0042772)3.77802630
58regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.75499464
59mitotic chromosome condensation (GO:0007076)3.74682408
60NLS-bearing protein import into nucleus (GO:0006607)3.73380078
61DNA duplex unwinding (GO:0032508)3.70354176
62regulation of gene silencing by RNA (GO:0060966)3.69088805
63regulation of posttranscriptional gene silencing (GO:0060147)3.69088805
64regulation of gene silencing by miRNA (GO:0060964)3.69088805
65positive regulation of protein deacetylation (GO:0090312)3.67995188
66DNA geometric change (GO:0032392)3.66508365
67regulation of cell proliferation involved in kidney development (GO:1901722)3.62650822
68negative regulation of translation, ncRNA-mediated (GO:0040033)3.60415134
69regulation of translation, ncRNA-mediated (GO:0045974)3.60415134
70negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.60415134
71monoubiquitinated protein deubiquitination (GO:0035520)3.60293429
72histone H3-K4 methylation (GO:0051568)3.57395521
73negative regulation of Rho protein signal transduction (GO:0035024)3.56687001
74primitive streak formation (GO:0090009)3.56134192
75DNA replication checkpoint (GO:0000076)3.55022717
76negative regulation of telomere maintenance (GO:0032205)3.49553580
77regulation of telomere maintenance (GO:0032204)3.49360792
78interferon-gamma production (GO:0032609)3.48652671
79branching involved in mammary gland duct morphogenesis (GO:0060444)3.47280712
80negative regulation of epidermal cell differentiation (GO:0045605)3.47179011
81regulation of translation in response to stress (GO:0043555)3.46642181
82positive regulation of synapse maturation (GO:0090129)3.44355354
83negative regulation of systemic arterial blood pressure (GO:0003085)3.42799643
84intracellular estrogen receptor signaling pathway (GO:0030520)3.38073933
85cell fate commitment involved in formation of primary germ layer (GO:0060795)3.37679277
86snRNA transcription (GO:0009301)3.35595463
87trophectodermal cell differentiation (GO:0001829)3.34073269
88hormone catabolic process (GO:0042447)3.32828193
89establishment of mitotic spindle orientation (GO:0000132)3.32811173
90intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.31323482
91regulation of synapse maturation (GO:0090128)3.30855734
92regulation of cilium movement (GO:0003352)3.30369716
93establishment of spindle orientation (GO:0051294)3.29146274
94histone H3-K4 trimethylation (GO:0080182)3.28281399
95regulation of hippo signaling (GO:0035330)3.27730675
96intestinal epithelial cell development (GO:0060576)3.27716523
97protein K48-linked deubiquitination (GO:0071108)3.26551411
98cytidine deamination (GO:0009972)3.25060229
99cytidine metabolic process (GO:0046087)3.25060229
100cytidine catabolic process (GO:0006216)3.25060229
101DNA unwinding involved in DNA replication (GO:0006268)3.23150107
102behavioral response to nicotine (GO:0035095)3.21866752
103pericardium development (GO:0060039)3.20690702
104opsonization (GO:0008228)3.19756728
105negative regulation of potassium ion transmembrane transport (GO:1901380)3.17652998
106retinoic acid receptor signaling pathway (GO:0048384)3.15152775
107maintenance of protein localization in organelle (GO:0072595)3.12681262
108mitochondrion distribution (GO:0048311)3.12411438
109cellular response to exogenous dsRNA (GO:0071360)3.09105209
110regulation of fatty acid beta-oxidation (GO:0031998)3.08393585
111positive regulation of cardiac muscle cell differentiation (GO:2000727)3.05102804
112regulation of mesoderm development (GO:2000380)3.05028514
113inner cell mass cell proliferation (GO:0001833)3.03091106
114nucleoside transmembrane transport (GO:1901642)3.01741267
115epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.01612235
116fibroblast migration (GO:0010761)3.01358670
117regulation of apoptotic process involved in morphogenesis (GO:1902337)3.01259212
118nucleus localization (GO:0051647)2.99572789
119camera-type eye morphogenesis (GO:0048593)2.98592731
120response to dietary excess (GO:0002021)2.97276285
121spindle assembly (GO:0051225)2.96389146
122regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.96083641
123regulation of skeletal muscle contraction (GO:0014819)2.96066138
124rRNA methylation (GO:0031167)2.95985541
125cytoplasmic mRNA processing body assembly (GO:0033962)2.95805645
126negative regulation of histone methylation (GO:0031061)2.94988890
127cardiovascular system development (GO:0072358)2.93641544
128lymphangiogenesis (GO:0001946)2.93370323
129regulation of heart morphogenesis (GO:2000826)2.90618666
130phenol-containing compound catabolic process (GO:0019336)2.88682478
131metanephros development (GO:0001656)2.88266494
132intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.87796451
133maternal placenta development (GO:0001893)2.87142602
134DNA conformation change (GO:0071103)2.86736249
135regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.86579992
136positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.84935178
137regulation of double-strand break repair (GO:2000779)2.83619980
138proline transport (GO:0015824)2.82762648
139regulation of somitogenesis (GO:0014807)2.81812970
140mitotic nuclear envelope disassembly (GO:0007077)2.81564836
141establishment of mitotic spindle localization (GO:0040001)2.80549560
142regulation of DNA-dependent DNA replication (GO:0090329)2.79664150
143spinal cord development (GO:0021510)2.78609344
144stress granule assembly (GO:0034063)2.78503575
145regulation of telomerase activity (GO:0051972)2.74818704
146middle ear morphogenesis (GO:0042474)2.74463478
147parturition (GO:0007567)2.74174193
148regulation of organ formation (GO:0003156)2.72854447
149negative regulation of gene silencing (GO:0060969)2.72605633
150regulation of fatty acid oxidation (GO:0046320)2.72527350
151positive regulation of gene expression, epigenetic (GO:0045815)2.72463215
152chromosome condensation (GO:0030261)2.72428272
153lung epithelial cell differentiation (GO:0060487)2.71815117
154cell migration involved in gastrulation (GO:0042074)2.71446921
155positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.69719478
156apoptotic DNA fragmentation (GO:0006309)2.69593112
157peripheral nervous system axon ensheathment (GO:0032292)2.69569988
158myelination in peripheral nervous system (GO:0022011)2.69569988
159microtubule severing (GO:0051013)2.69445884
160establishment of spindle localization (GO:0051293)2.68349033
161tooth mineralization (GO:0034505)2.67000917
162membrane disassembly (GO:0030397)2.66461653
163nuclear envelope disassembly (GO:0051081)2.66461653
164artery development (GO:0060840)2.66157736
165striated muscle atrophy (GO:0014891)2.64766245
166protein K63-linked deubiquitination (GO:0070536)2.63573842
167histone H3-K36 demethylation (GO:0070544)2.62883123
168regulation of energy homeostasis (GO:2000505)2.62733299
169serotonin metabolic process (GO:0042428)2.62254004
170regulation of membrane repolarization (GO:0060306)2.60995469
171membrane repolarization (GO:0086009)2.59324448
172establishment of protein localization to Golgi (GO:0072600)2.54609798
173lung-associated mesenchyme development (GO:0060484)2.51972723
174ventricular septum development (GO:0003281)2.51658908
175auditory receptor cell differentiation (GO:0042491)2.50443717
176phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.50210785
177endocardial cushion development (GO:0003197)2.48750825
178muscle atrophy (GO:0014889)2.48492791
179lung cell differentiation (GO:0060479)2.47595182
180appendage development (GO:0048736)2.46621817
181limb development (GO:0060173)2.46621817
182response to electrical stimulus (GO:0051602)2.45716827
183ovulation cycle (GO:0042698)2.45696424
184metanephric mesenchyme development (GO:0072075)2.45488409
185positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.42980080
186relaxation of cardiac muscle (GO:0055119)2.40963400
187branching involved in labyrinthine layer morphogenesis (GO:0060670)2.39179769
188negative regulation of protein localization to cell surface (GO:2000009)2.38609831
189regulation of endothelial cell differentiation (GO:0045601)2.37707413
190negative regulation of transcription regulatory region DNA binding (GO:2000678)2.34333184
191mitochondrial respiratory chain complex I assembly (GO:0032981)2.33896408
192NADH dehydrogenase complex assembly (GO:0010257)2.33896408
193mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.33896408
194smooth muscle tissue development (GO:0048745)2.33591062

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.24113218
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.49765931
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.49765931
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.49765931
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.55353856
6EZH2_22144423_ChIP-Seq_EOC_Human4.20494976
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.39942009
8TP63_19390658_ChIP-ChIP_HaCaT_Human3.14909268
9SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.02264568
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.94635365
11NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.94635154
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.85143409
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.67435536
14POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.64178465
15SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.59364805
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.59158412
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.56599037
18AHR_22903824_ChIP-Seq_MCF-7_Human2.50525804
19MYC_22102868_ChIP-Seq_BL_Human2.38260114
20TCF3_18692474_ChIP-Seq_MESCs_Mouse2.38136918
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.35546107
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.22361704
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.16922890
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16400038
25TCF3_18692474_ChIP-Seq_MEFs_Mouse2.13613934
26ARNT_22903824_ChIP-Seq_MCF-7_Human2.13018359
27NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.07991880
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.98877155
29ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.94314627
30SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.90245436
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.89690011
32DROSHA_22980978_ChIP-Seq_HELA_Human1.87197236
33ZFP281_27345836_Chip-Seq_ESCs_Mouse1.84945296
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.84823711
35VDR_22108803_ChIP-Seq_LS180_Human1.82851886
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.82685720
37ZFP281_18757296_ChIP-ChIP_E14_Mouse1.82605819
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79169858
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79036533
40GBX2_23144817_ChIP-Seq_PC3_Human1.78400213
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.77624700
42POU5F1_16518401_ChIP-PET_MESCs_Mouse1.76848918
43RUNX_20019798_ChIP-Seq_JUKART_Human1.74992171
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72238185
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.69117268
46NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.66838440
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65391052
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.65211955
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.64332904
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.63565861
51TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.63197906
52JARID2_20075857_ChIP-Seq_MESCs_Mouse1.62405984
53NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.60827034
54TCF7_22412390_ChIP-Seq_EML_Mouse1.60241776
55RNF2_27304074_Chip-Seq_ESCs_Mouse1.59761060
56STAT3_23295773_ChIP-Seq_U87_Human1.57717833
57KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.57404543
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56552045
59AR_21572438_ChIP-Seq_LNCaP_Human1.56519639
60TP53_16413492_ChIP-PET_HCT116_Human1.54930552
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54416248
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.52750672
63TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.51553124
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.51510262
65TDRD3_21172665_ChIP-Seq_MCF-7_Human1.51412629
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.51131964
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50351888
68EZH2_27304074_Chip-Seq_ESCs_Mouse1.47545386
69MYC_19079543_ChIP-ChIP_MESCs_Mouse1.47321041
70TCF4_23295773_ChIP-Seq_U87_Human1.46874200
71NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46696906
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42640873
73PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.40847192
74ZNF274_21170338_ChIP-Seq_K562_Hela1.40001362
75NANOG_18692474_ChIP-Seq_MESCs_Mouse1.39236589
76STAT6_21828071_ChIP-Seq_BEAS2B_Human1.39021536
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38204973
78ER_23166858_ChIP-Seq_MCF-7_Human1.38079707
79RXR_22108803_ChIP-Seq_LS180_Human1.37434521
80JARID2_20064375_ChIP-Seq_MESCs_Mouse1.35586439
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34605027
82SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34481002
83WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32804694
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32170552
85ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32130341
86MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29952174
87POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.29269616
88E2F1_17053090_ChIP-ChIP_MCF-7_Human1.28087269
89RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27640373
90NANOG_21062744_ChIP-ChIP_HESCs_Human1.27549097
91KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26297406
92MYC_18555785_ChIP-Seq_MESCs_Mouse1.26200884
93FUS_26573619_Chip-Seq_HEK293_Human1.26113199
94POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25366100
95BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24979602
96SOX2_18692474_ChIP-Seq_MESCs_Mouse1.24799026
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24060080
98EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23895919
99ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23115360
100RNF2_18974828_ChIP-Seq_MESCs_Mouse1.22044286
101EZH2_18974828_ChIP-Seq_MESCs_Mouse1.22044286
102NCOR1_26117541_ChIP-Seq_K562_Human1.21177279
103NANOG_16518401_ChIP-PET_MESCs_Mouse1.18110072
104NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17149421
105P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17066142
106NANOG_18692474_ChIP-Seq_MEFs_Mouse1.16200251
107LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15289689
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15090124
109SMAD_19615063_ChIP-ChIP_OVARY_Human1.14937663
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14665357
111* SMAD4_21799915_ChIP-Seq_A2780_Human1.14240407
112ISL1_27105846_Chip-Seq_CPCs_Mouse1.13445880
113NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13118480
114ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12651430
115PIAS1_25552417_ChIP-Seq_VCAP_Human1.12303871
116KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11888450
117FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11887817
118SALL1_21062744_ChIP-ChIP_HESCs_Human1.11568600
119TP53_22127205_ChIP-Seq_IMR90_Human1.11531624
120SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11338329
121MYC_19030024_ChIP-ChIP_MESCs_Mouse1.11337090
122MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11004510
123KDM2B_26808549_Chip-Seq_K562_Human1.10319151
124WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10017391
125POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.09911220
126TBX3_20139965_ChIP-Seq_ESCs_Mouse1.09641091
127TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.09287136
128PRDM14_20953172_ChIP-Seq_ESCs_Human1.08783399
129KDM2B_26808549_Chip-Seq_REH_Human1.08440873
130TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08085267
131POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08085267
132TBX3_20139965_ChIP-Seq_MESCs_Mouse1.07794582
133RNF2_27304074_Chip-Seq_NSC_Mouse1.07770333
134KDM2B_26808549_Chip-Seq_DND41_Human1.07729108
135SOX2_21211035_ChIP-Seq_LN229_Gbm1.07114444
136RING1B_27294783_Chip-Seq_NPCs_Mouse1.06701729
137HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06207180
138STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06203419
139CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06154685
140AR_19668381_ChIP-Seq_PC3_Human1.05956904
141CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05905968
142PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05558590
143SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05528167
144OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05077014
145TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03941718
146CIITA_25753668_ChIP-Seq_RAJI_Human1.03428234
147GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02978129
148GATA1_26923725_Chip-Seq_HPCs_Mouse1.00304947
149SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00043970
150SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99624929
151NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98993978
152MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98689181
153HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98672866
154GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98219998
155EZH2_27294783_Chip-Seq_ESCs_Mouse0.98013133
156WDR5_24793694_ChIP-Seq_LNCAP_Human0.96816803
157UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96787047
158SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96696031
159EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.95913018
160GF1_26923725_Chip-Seq_HPCs_Mouse0.95678571
161* EWS_26573619_Chip-Seq_HEK293_Human0.95500786
162IRF1_19129219_ChIP-ChIP_H3396_Human0.94121291
163FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.93970676
164DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93825940
165FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93520883
166* ELK3_25401928_ChIP-Seq_HUVEC_Human0.92817144
167ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92324240
168KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91778126
169TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91695845
170KDM5A_27292631_Chip-Seq_BREAST_Human0.91682517
171SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91203041
172SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90781799
173STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90588621
174SMC4_20622854_ChIP-Seq_HELA_Human0.90296558
175NANOG_16153702_ChIP-ChIP_HESCs_Human0.89440109
176CDX2_20551321_ChIP-Seq_CACO-2_Human0.87619892
177SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86519437
178RACK7_27058665_Chip-Seq_MCF-7_Human0.86107366
179YY1_21170310_ChIP-Seq_MESCs_Mouse0.84723059
180AR_21909140_ChIP-Seq_LNCAP_Human0.83990560
181E2F1_21310950_ChIP-Seq_MCF-7_Human0.79183902
182P68_20966046_ChIP-Seq_HELA_Human0.78697147
183SCL_19346495_ChIP-Seq_HPC-7_Human0.78538787
184KAP1_27257070_Chip-Seq_ESCs_Mouse0.78461343
185RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.78369263
186FOXO3_23340844_ChIP-Seq_DLD1_Human0.78175403
187VDR_21846776_ChIP-Seq_THP-1_Human0.77036740
188LXR_22292898_ChIP-Seq_THP-1_Human0.76281011

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.14062424
2MP0004264_abnormal_extraembryonic_tissu3.92770302
3MP0003890_abnormal_embryonic-extraembry3.53360496
4MP0001485_abnormal_pinna_reflex3.42003490
5MP0002254_reproductive_system_inflammat3.36047496
6MP0008057_abnormal_DNA_replication3.28682889
7MP0003646_muscle_fatigue3.23098921
8MP0006292_abnormal_olfactory_placode3.10976356
9MP0004858_abnormal_nervous_system2.95771287
10MP0003122_maternal_imprinting2.93482396
11MP0003705_abnormal_hypodermis_morpholog2.90347848
12MP0003011_delayed_dark_adaptation2.88227015
13MP0003121_genomic_imprinting2.81234206
14MP0005499_abnormal_olfactory_system2.80929636
15MP0005394_taste/olfaction_phenotype2.80929636
16MP0010352_gastrointestinal_tract_polyps2.71134231
17MP0004957_abnormal_blastocyst_morpholog2.69562640
18MP0004130_abnormal_muscle_cell2.63786633
19MP0002653_abnormal_ependyma_morphology2.41057069
20MP0008961_abnormal_basal_metabolism2.38889447
21MP0003942_abnormal_urinary_system2.38609144
22MP0009384_cardiac_valve_regurgitation2.30288275
23MP0005380_embryogenesis_phenotype2.18796281
24MP0001672_abnormal_embryogenesis/_devel2.18796281
25MP0005075_abnormal_melanosome_morpholog2.15017262
26MP0002332_abnormal_exercise_endurance2.14714810
27MP0003123_paternal_imprinting2.09201489
28MP0009250_abnormal_appendicular_skeleto2.07449754
29MP0002088_abnormal_embryonic_growth/wei2.06916635
30MP0003984_embryonic_growth_retardation2.06908054
31MP0000534_abnormal_ureter_morphology2.06881040
32MP0003879_abnormal_hair_cell1.99270175
33MP0004145_abnormal_muscle_electrophysio1.94400631
34MP0000631_abnormal_neuroendocrine_gland1.93144538
35MP0003111_abnormal_nucleus_morphology1.91891358
36MP0003077_abnormal_cell_cycle1.87878145
37MP0003787_abnormal_imprinting1.87018228
38MP0001440_abnormal_grooming_behavior1.81504997
39MP0000350_abnormal_cell_proliferation1.81440295
40MP0005257_abnormal_intraocular_pressure1.79683919
41MP0010094_abnormal_chromosome_stability1.72997059
42MP0001849_ear_inflammation1.72822180
43MP0002086_abnormal_extraembryonic_tissu1.67980586
44MP0005174_abnormal_tail_pigmentation1.66419327
45MP0002084_abnormal_developmental_patter1.64697849
46MP0002085_abnormal_embryonic_tissue1.64677360
47MP0000678_abnormal_parathyroid_gland1.63330936
48MP0008995_early_reproductive_senescence1.62114548
49MP0001293_anophthalmia1.59351142
50MP0006035_abnormal_mitochondrial_morpho1.58097782
51MP0002127_abnormal_cardiovascular_syste1.56222379
52MP0003283_abnormal_digestive_organ1.52281203
53MP0004197_abnormal_fetal_growth/weight/1.50728309
54MP0005670_abnormal_white_adipose1.49961585
55MP0004134_abnormal_chest_morphology1.49384791
56MP0001730_embryonic_growth_arrest1.48822178
57MP0010030_abnormal_orbit_morphology1.46559606
58MP0002396_abnormal_hematopoietic_system1.42577399
59MP0001879_abnormal_lymphatic_vessel1.41288529
60MP0008877_abnormal_DNA_methylation1.39102262
61MP0003119_abnormal_digestive_system1.37807852
62MP0002092_abnormal_eye_morphology1.35821038
63MP0003938_abnormal_ear_development1.35367163
64MP0000428_abnormal_craniofacial_morphol1.34817605
65MP0000383_abnormal_hair_follicle1.32968476
66MP0000733_abnormal_muscle_development1.32915249
67MP0000026_abnormal_inner_ear1.31805436
68MP0003183_abnormal_peptide_metabolism1.31789251
69MP0000013_abnormal_adipose_tissue1.29218894
70MP0001697_abnormal_embryo_size1.26192472
71MP0002932_abnormal_joint_morphology1.25071595
72MP0003935_abnormal_craniofacial_develop1.23309345
73MP0005409_darkened_coat_color1.20068250
74MP0001661_extended_life_span1.18024881
75MP0008770_decreased_survivor_rate1.16245505
76MP0002080_prenatal_lethality1.15879361
77MP0002177_abnormal_outer_ear1.15871066
78MP0005076_abnormal_cell_differentiation1.15191843
79MP0002925_abnormal_cardiovascular_devel1.14356423
80MP0009703_decreased_birth_body1.13810136
81MP0000432_abnormal_head_morphology1.10982929
82MP0000470_abnormal_stomach_morphology1.10185713
83MP0004885_abnormal_endolymph1.10092983
84MP0002114_abnormal_axial_skeleton1.08727926
85MP0002160_abnormal_reproductive_system1.08136154
86MP0001963_abnormal_hearing_physiology1.06180087
87MP0002233_abnormal_nose_morphology1.05941905
88MP0002269_muscular_atrophy1.03224820
89MP0004085_abnormal_heartbeat1.02302443
90MP0000313_abnormal_cell_death1.00457076
91MP0000049_abnormal_middle_ear0.99659631
92MP0005266_abnormal_metabolism0.99022035
93MP0003137_abnormal_impulse_conducting0.97818290
94MP0000371_diluted_coat_color0.97718855
95MP0002938_white_spotting0.96680774
96MP0000427_abnormal_hair_cycle0.96234889
97MP0005623_abnormal_meninges_morphology0.96234439
98MP0006138_congestive_heart_failure0.96177262
99MP0008789_abnormal_olfactory_epithelium0.96117750
100MP0001986_abnormal_taste_sensitivity0.95579300
101MP0004742_abnormal_vestibular_system0.94777069
102MP0004381_abnormal_hair_follicle0.94394286
103MP0004133_heterotaxia0.94351887
104MP0003936_abnormal_reproductive_system0.93422955
105MP0005248_abnormal_Harderian_gland0.93396932
106MP0002970_abnormal_white_adipose0.93395233
107MP0008007_abnormal_cellular_replicative0.93224582
108MP0002928_abnormal_bile_duct0.93057754
109MP0002108_abnormal_muscle_morphology0.92768076
110MP0009115_abnormal_fat_cell0.92638211
111MP0003755_abnormal_palate_morphology0.90865322
112MP0004142_abnormal_muscle_tone0.90434590
113MP0000767_abnormal_smooth_muscle0.89888516
114MP0000778_abnormal_nervous_system0.89515265
115MP0003861_abnormal_nervous_system0.88120021
116MP0002184_abnormal_innervation0.88036553
117MP0008775_abnormal_heart_ventricle0.87722107
118MP0000762_abnormal_tongue_morphology0.87541203
119MP0008932_abnormal_embryonic_tissue0.86949290
120MP0002752_abnormal_somatic_nervous0.85190709
121MP0000750_abnormal_muscle_regeneration0.83623332
122MP0005391_vision/eye_phenotype0.82460540
123MP0005551_abnormal_eye_electrophysiolog0.80702911
124MP0003567_abnormal_fetal_cardiomyocyte0.80533462
125MP0010630_abnormal_cardiac_muscle0.79679625
126MP0002109_abnormal_limb_morphology0.79428463
127MP0002116_abnormal_craniofacial_bone0.79327817
128MP0003385_abnormal_body_wall0.79209554
129MP0003693_abnormal_embryo_hatching0.77300917
130MP0000266_abnormal_heart_morphology0.76138737
131MP0003115_abnormal_respiratory_system0.75685979
132MP0005620_abnormal_muscle_contractility0.75361950
133MP0003566_abnormal_cell_adhesion0.74591171
134MP0005023_abnormal_wound_healing0.74265600
135MP0002081_perinatal_lethality0.74078999
136MP0000490_abnormal_crypts_of0.73612834
137MP0002135_abnormal_kidney_morphology0.73170874
138MP0005384_cellular_phenotype0.72627736
139MP0002168_other_aberrant_phenotype0.72052407
140MP0002249_abnormal_larynx_morphology0.71570834
141MP0001502_abnormal_circadian_rhythm0.71087310
142MP0005195_abnormal_posterior_eye0.70466273
143MP0003763_abnormal_thymus_physiology0.69640129
144MP0003937_abnormal_limbs/digits/tail_de0.69346105
145MP0005389_reproductive_system_phenotype0.69287995
146MP0001177_atelectasis0.68775321
147MP0000163_abnormal_cartilage_morphology0.68716885
148MP0002128_abnormal_blood_circulation0.68483676
149MP0005083_abnormal_biliary_tract0.68250545
150MP0009053_abnormal_anal_canal0.67296844
151MP0002089_abnormal_postnatal_growth/wei0.66875944
152MP0001348_abnormal_lacrimal_gland0.65439254
153MP0004185_abnormal_adipocyte_glucose0.64053495
154MP0005595_abnormal_vascular_smooth0.63884413
155MP0010307_abnormal_tumor_latency0.63525889
156MP0000003_abnormal_adipose_tissue0.63489683
157MP0001286_abnormal_eye_development0.63238867
158MP0009672_abnormal_birth_weight0.62441546
159MP0002697_abnormal_eye_size0.62386276
160MP0000749_muscle_degeneration0.61083057
161MP0004087_abnormal_muscle_fiber0.60063868
162MP0002111_abnormal_tail_morphology0.59449227
163MP0005621_abnormal_cell_physiology0.59372778
164MP0003045_fibrosis0.58982796
165MP0004084_abnormal_cardiac_muscle0.58297509
166MP0002877_abnormal_melanocyte_morpholog0.58136804
167MP0003315_abnormal_perineum_morphology0.57549525
168MP0002019_abnormal_tumor_incidence0.57259392

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the renal collecting system (HP:0004742)6.47246774
2Bilateral microphthalmos (HP:0007633)6.16305255
3Lip pit (HP:0100267)5.77450817
4Stenosis of the external auditory canal (HP:0000402)5.54383971
5Abnormality of the lower motor neuron (HP:0002366)5.25799762
6Hypochromic microcytic anemia (HP:0004840)5.18048947
7Ependymoma (HP:0002888)4.82389266
8Hepatoblastoma (HP:0002884)4.77639411
9Clumsiness (HP:0002312)4.77346614
10Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.36438391
11Short 4th metacarpal (HP:0010044)4.36438391
12Abnormality of cochlea (HP:0000375)4.16892848
13Rib fusion (HP:0000902)4.10529049
14Genetic anticipation (HP:0003743)4.00347036
15Morphological abnormality of the middle ear (HP:0008609)3.97380608
16Multiple enchondromatosis (HP:0005701)3.88768287
17Abnormality of the astrocytes (HP:0100707)3.78936948
18Astrocytoma (HP:0009592)3.78936948
19Neoplasm of striated muscle (HP:0009728)3.77582876
20Down-sloping shoulders (HP:0200021)3.63753273
21Decreased circulating renin level (HP:0003351)3.63051746
22Rhabdomyosarcoma (HP:0002859)3.45412349
23Chromosomal breakage induced by crosslinking agents (HP:0003221)3.34757200
24Duplicated collecting system (HP:0000081)3.20853721
25Nephroblastoma (Wilms tumor) (HP:0002667)3.20831480
26Morphological abnormality of the inner ear (HP:0011390)3.19312385
27Megalencephaly (HP:0001355)3.17742865
28Abnormality of the 4th metacarpal (HP:0010012)3.15443258
29Chromsome breakage (HP:0040012)2.99136376
30Ectopic kidney (HP:0000086)2.96599556
31Abnormality of the right ventricle (HP:0001707)2.95427622
32Embryonal renal neoplasm (HP:0011794)2.95312316
33Amyotrophic lateral sclerosis (HP:0007354)2.94438688
34Persistence of primary teeth (HP:0006335)2.88628086
35Intestinal fistula (HP:0100819)2.87858308
36Abnormality of the salivary glands (HP:0010286)2.85380464
37Glioma (HP:0009733)2.84386670
38Testicular atrophy (HP:0000029)2.71337215
39Renal duplication (HP:0000075)2.70399272
40Rectovaginal fistula (HP:0000143)2.66674686
41Rectal fistula (HP:0100590)2.66674686
42Short humerus (HP:0005792)2.66376557
43Preauricular skin tag (HP:0000384)2.62007029
44Fused cervical vertebrae (HP:0002949)2.60911447
45Abnormality of the parathyroid morphology (HP:0011766)2.58958659
46Progressive cerebellar ataxia (HP:0002073)2.57705929
47Abnormality of chromosome segregation (HP:0002916)2.57309690
48Aplasia/hypoplasia of the humerus (HP:0006507)2.56572509
49Shawl scrotum (HP:0000049)2.56309455
50Skin tags (HP:0010609)2.55876736
51Difficulty running (HP:0009046)2.50940701
52Neoplasm of the heart (HP:0100544)2.50642587
53Abnormality of DNA repair (HP:0003254)2.50100708
54Hyperventilation (HP:0002883)2.48350267
55Pseudobulbar signs (HP:0002200)2.46657364
56Large earlobe (HP:0009748)2.45883270
57Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.41619041
58Short 1st metacarpal (HP:0010034)2.41619041
59Horizontal nystagmus (HP:0000666)2.40764871
60Bifid tongue (HP:0010297)2.40420408
61Increased connective tissue (HP:0009025)2.39803752
62Abnormality of the nasal septum (HP:0000419)2.37108221
63Hand muscle atrophy (HP:0009130)2.37062538
64Chronic hepatic failure (HP:0100626)2.36946294
65Renal dysplasia (HP:0000110)2.36511889
66Hypopigmentation of the fundus (HP:0007894)2.36160407
67Impulsivity (HP:0100710)2.34991996
68Oligodontia (HP:0000677)2.33992551
69Hypoplasia of the fovea (HP:0007750)2.33734328
70Aplasia/Hypoplasia of the fovea (HP:0008060)2.33734328
71Generalized hypotonia (HP:0001290)2.33473919
72Abnormal lung lobation (HP:0002101)2.32727706
73Ragged-red muscle fibers (HP:0003200)2.32137630
74Medulloblastoma (HP:0002885)2.31743635
75Volvulus (HP:0002580)2.30947085
76Resting tremor (HP:0002322)2.29609723
77Mesomelia (HP:0003027)2.28736639
78Aplasia/Hypoplasia of the tibia (HP:0005772)2.28730389
79Aplasia/Hypoplasia of the sternum (HP:0006714)2.28625803
80Abnormality of the fingertips (HP:0001211)2.26802726
81Patent foramen ovale (HP:0001655)2.22288888
82Hyperinsulinemic hypoglycemia (HP:0000825)2.22247430
83Malignant neoplasm of the central nervous system (HP:0100836)2.21186403
84Vaginal fistula (HP:0004320)2.20890544
85Abolished electroretinogram (ERG) (HP:0000550)2.20157076
86Preauricular pit (HP:0004467)2.19896191
87Periauricular skin pits (HP:0100277)2.19896191
88Abnormality of the distal phalanx of the thumb (HP:0009617)2.18582189
89Adactyly (HP:0009776)2.18303485
90Meckel diverticulum (HP:0002245)2.17918728
91Abnormality of the pulmonary veins (HP:0011718)2.17005915
92Partial duplication of thumb phalanx (HP:0009944)2.15877867
93Abnormality of the musculature of the hand (HP:0001421)2.15464135
94Obstructive sleep apnea (HP:0002870)2.15085997
95Supernumerary ribs (HP:0005815)2.14458109
96Increased nuchal translucency (HP:0010880)2.13962536
97Aplasia/Hypoplasia of the uvula (HP:0010293)2.11611395
98Short 5th finger (HP:0009237)2.11577715
99Gaze-evoked nystagmus (HP:0000640)2.09662521
100Neoplasm of the oral cavity (HP:0100649)2.09287674
101Short phalanx of the thumb (HP:0009660)2.08772781
102Hypoplasia of the ulna (HP:0003022)2.08565915
103Tetraplegia (HP:0002445)2.08323678
104Metabolic alkalosis (HP:0200114)2.08141717
105Aplasia/Hypoplasia of the patella (HP:0006498)2.07253734
106Aplasia/Hypoplasia of the fibula (HP:0006492)2.06209047
107Abnormality of the ileum (HP:0001549)2.05243128
108Synostosis of carpal bones (HP:0005048)2.04025882
109Abnormality of the pubic bones (HP:0003172)2.02865373
110Macroorchidism (HP:0000053)2.02382874
111Nasolacrimal duct obstruction (HP:0000579)2.02063890
112Hypochromic anemia (HP:0001931)2.01310829
113Protruding tongue (HP:0010808)2.00630616
114Abnormality of the 1st metacarpal (HP:0010009)2.00541524
115Upper limb amyotrophy (HP:0009129)2.00220930
116Distal upper limb amyotrophy (HP:0007149)2.00220930
117Anomalous pulmonary venous return (HP:0010772)1.99916093
118Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.99650235
119Truncal obesity (HP:0001956)1.98615959
120Upper motor neuron abnormality (HP:0002127)1.97649884
121Fibular hypoplasia (HP:0003038)1.97127177
122Partial duplication of the phalanx of hand (HP:0009999)1.96135096
123Small hand (HP:0200055)1.95826951
124Trismus (HP:0000211)1.95352111
125Skin pits (HP:0100276)1.94868833
126Abnormality of the phalanges of the hallux (HP:0010057)1.93998771
127Radial bowing (HP:0002986)1.93649599
128Patellar aplasia (HP:0006443)1.92989624
129Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.92862815
130Fibular aplasia (HP:0002990)1.92296937
131Pancreatic cysts (HP:0001737)1.91306988
132Leiomyosarcoma (HP:0100243)1.90554490
133Uterine leiomyosarcoma (HP:0002891)1.90554490
134Vertebral fusion (HP:0002948)1.89801231
135Pancreatic fibrosis (HP:0100732)1.89673534
136Short hallux (HP:0010109)1.89620028
137Heterotopia (HP:0002282)1.89344188
138Nephronophthisis (HP:0000090)1.89332970
139Broad palm (HP:0001169)1.89191987
140Short tibia (HP:0005736)1.89051824
141Pendular nystagmus (HP:0012043)1.89006322
142Missing ribs (HP:0000921)1.87607848
143Supernumerary bones of the axial skeleton (HP:0009144)1.87320588
144Prominent nose (HP:0000448)1.86915183
145Abnormal cartilage morphology (HP:0002763)1.85485337
146EMG: neuropathic changes (HP:0003445)1.85353508
147Osteomalacia (HP:0002749)1.84645148
148Abnormality of the phalanges of the 2nd finger (HP:0009541)1.84263335
149Cupped ear (HP:0000378)1.84216030
150Neuroectodermal neoplasm (HP:0030061)1.83916853
151Neuroepithelial neoplasm (HP:0030063)1.83916853
152Nervous tissue neoplasm (HP:0030060)1.83916853
153Supernumerary spleens (HP:0009799)1.83621355
154Narrow palate (HP:0000189)1.83456451
155Absent frontal sinuses (HP:0002688)1.82507407
156Supernumerary nipples (HP:0002558)1.81834793
157Abnormality of small intestinal villus morphology (HP:0011472)1.81109038
158Villous atrophy (HP:0011473)1.81109038
159Broad thumb (HP:0011304)1.79580733
160Atrophy/Degeneration involving motor neurons (HP:0007373)1.79433294
161Abnormality of the renal medulla (HP:0100957)1.79404316
162Aplasia/Hypoplasia of the macula (HP:0008059)1.79317165
163Spinal muscular atrophy (HP:0007269)1.79100383
164Broad-based gait (HP:0002136)1.75063901
165Absent thumb (HP:0009777)1.74287192
166Tented upper lip vermilion (HP:0010804)1.74207926
167True hermaphroditism (HP:0010459)1.73426047
168Cerebral palsy (HP:0100021)1.73323106
169Urinary bladder sphincter dysfunction (HP:0002839)1.73079067
170Tubular atrophy (HP:0000092)1.73069928
171Neonatal hypoglycemia (HP:0001998)1.70053731
172Sandal gap (HP:0001852)1.69368261
173Aplasia/Hypoplasia of the ulna (HP:0006495)1.67191813
174Short femoral neck (HP:0100864)1.66268574
175Aplasia/Hypoplasia of the hallux (HP:0008362)1.65828931
176Hypoplastic iliac wings (HP:0002866)1.64882338
177Broad hallux (HP:0010055)1.64192025
178Scapular winging (HP:0003691)1.63162422
179Abnormality of the epiphyses of the hand (HP:0005924)1.60225204
180Abnormality of the nasolacrimal system (HP:0000614)1.59995585
181Hypoplasia of the maxilla (HP:0000327)1.59478325
182Concave nail (HP:0001598)1.59473522
183Abnormality of the proximal phalanges of the hand (HP:0009834)1.59153156
184Increased number of teeth (HP:0011069)1.58549448
185Exostoses (HP:0100777)1.57393197
186Goiter (HP:0000853)1.57244834
187Abnormality of the ischium (HP:0003174)1.57222611
188Abnormality of the lacrimal duct (HP:0011481)1.55231822
189Abnormality of midbrain morphology (HP:0002418)1.54384062
190Molar tooth sign on MRI (HP:0002419)1.54384062
191Bradycardia (HP:0001662)1.54050612
192Hypoplastic ischia (HP:0003175)1.53852692
193Submucous cleft hard palate (HP:0000176)1.53706180

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.92193929
2GRK53.94464059
3ERN13.57937735
4GRK63.49512224
5FRK3.20673208
6TYRO32.75039223
7TTK2.60113101
8CSF1R2.42703382
9SGK22.32944132
10STK102.10929896
11GRK12.05942064
12TGFBR22.04918426
13WNK12.02983447
14TLK11.95433795
15MAPK71.88004416
16MAP3K101.85001992
17BLK1.75890728
18ADRBK21.74747056
19CDC71.70226822
20SGK31.68330690
21MATK1.60880792
22RPS6KA61.59172933
23SGK4941.56368167
24SGK2231.56368167
25NLK1.54945635
26TAF11.54379850
27RPS6KA21.52042893
28GRK71.49434387
29CAMK41.46454034
30MARK21.45367410
31RPS6KC11.44729241
32RPS6KL11.44729241
33CDK71.40855629
34FGFR31.38614883
35NEK21.35064900
36ALK1.32873743
37MOS1.32585599
38MELK1.30886360
39PAK41.24381367
40CHEK21.21434120
41ACVR1B1.17995615
42EPHA31.17671758
43TRPM71.16424126
44NTRK11.13710758
45MTOR1.13670463
46BMPR1B1.12172068
47SGK11.12042937
48EPHA21.10523841
49CHEK11.10218375
50RIPK11.07731210
51PIK3CA1.07607546
52PLK11.07097568
53TNK21.05264490
54TXK1.02028962
55ICK1.01606202
56HIPK21.00831632
57TAOK31.00608092
58CHUK1.00533196
59MAP3K70.99139927
60EEF2K0.99046012
61NTRK30.96795232
62SIK20.96223350
63NEK90.95927041
64MAP2K40.95391761
65NEK10.92576798
66PRKAA20.92447239
67BRD40.91905294
68FGFR20.91182320
69LATS20.89737436
70PDGFRA0.88558056
71PRKG20.87358049
72MAP3K90.86483020
73MAP4K10.84422577
74STK110.81855265
75FGFR40.81329212
76LATS10.80240708
77AKT30.78319837
78TRIB30.78094813
79PAK30.77266722
80AKT20.77217652
81EPHB10.74372867
82CDK20.73262989
83CAMK1D0.72776741
84BTK0.71771592
85CDK40.71100945
86CDK90.70963772
87STK380.70802227
88RPS6KB20.68190836
89ATM0.64782430
90WNK40.64683129
91NUAK10.64625274
92ADRBK10.63867374
93MAP3K130.63810947
94TTN0.61349846
95MKNK20.61152105
96INSRR0.60592323
97CAMK10.58234943
98BMX0.57822701
99DMPK0.57315656
100MAPK30.56241250
101TAOK10.55934710
102CSK0.55899783
103TNIK0.55673185
104RPS6KA10.54827929
105PKN20.54750658
106PTK20.54018098
107HCK0.53793779
108IKBKB0.52538718
109ZAP700.51945188
110CSNK1E0.51129349
111KIT0.50979124
112SIK10.50235185
113MAPK40.49464874
114MAPK100.49419784
115CAMK1G0.48956594
116MAPK110.48880885
117PRKD30.48855012
118ATR0.48457142
119JAK10.47777203
120CDK10.47566755
121MAPK150.46744953
122RPS6KB10.45862499
123PKN10.44866177
124PAK60.41884737
125GSK3B0.41794343
126AURKB0.41205958
127MAPK140.40428196
128MAPK120.38586140
129ERBB20.38183080
130PRKAA10.37195105
131ITK0.37055453
132MAP2K60.36169377
133PRKCI0.35140523
134MAPK10.34980382
135NTRK20.34713310
136PRKD20.33092018
137CDC42BPA0.31779066
138CSNK1D0.31406916
139PDK40.30301252
140PDK30.30301252
141RPS6KA30.28785447
142STK30.27951565
143STK40.27929803
144IGF1R0.27535154
145MAPK80.26327741
146INSR0.24699313
147PDGFRB0.24139287
148AKT10.23969450
149SCYL20.23231432
150AURKA0.22905564
151PRKCH0.22638672
152PAK20.22586174
153DDR20.22051269
154MAP3K80.22019244
155DYRK1A0.20863002

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.97661890
2Vitamin B6 metabolism_Homo sapiens_hsa007503.92096824
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.17176582
4Fructose and mannose metabolism_Homo sapiens_hsa000512.59796503
5mTOR signaling pathway_Homo sapiens_hsa041502.22705566
6mRNA surveillance pathway_Homo sapiens_hsa030152.15547952
7RNA transport_Homo sapiens_hsa030131.98528782
8Galactose metabolism_Homo sapiens_hsa000521.67487785
9Type II diabetes mellitus_Homo sapiens_hsa049301.64851221
10Thyroid cancer_Homo sapiens_hsa052161.55057897
11Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.50754504
12Cholinergic synapse_Homo sapiens_hsa047251.50554700
13Cell cycle_Homo sapiens_hsa041101.50210555
14Thyroid hormone signaling pathway_Homo sapiens_hsa049191.49512767
15Selenocompound metabolism_Homo sapiens_hsa004501.48220446
16Vascular smooth muscle contraction_Homo sapiens_hsa042701.44762143
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44456684
18Fanconi anemia pathway_Homo sapiens_hsa034601.38655329
19One carbon pool by folate_Homo sapiens_hsa006701.33683500
20ECM-receptor interaction_Homo sapiens_hsa045121.33586903
21Vitamin digestion and absorption_Homo sapiens_hsa049771.32927811
22Central carbon metabolism in cancer_Homo sapiens_hsa052301.32381564
23MicroRNAs in cancer_Homo sapiens_hsa052061.31589750
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31022277
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.30621788
26Lysine degradation_Homo sapiens_hsa003101.28275411
27Melanoma_Homo sapiens_hsa052181.27079129
28Basal cell carcinoma_Homo sapiens_hsa052171.24196823
29FoxO signaling pathway_Homo sapiens_hsa040681.24153908
30ABC transporters_Homo sapiens_hsa020101.23999731
31Inositol phosphate metabolism_Homo sapiens_hsa005621.21025911
32DNA replication_Homo sapiens_hsa030301.19135607
33Morphine addiction_Homo sapiens_hsa050321.18513089
34Notch signaling pathway_Homo sapiens_hsa043301.15871279
35Phospholipase D signaling pathway_Homo sapiens_hsa040721.15781899
36Basal transcription factors_Homo sapiens_hsa030221.15640737
37Non-small cell lung cancer_Homo sapiens_hsa052231.14232097
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13716077
39Renin secretion_Homo sapiens_hsa049241.13655365
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13186778
41Mismatch repair_Homo sapiens_hsa034301.12512728
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10910556
43TGF-beta signaling pathway_Homo sapiens_hsa043501.09035959
44Circadian entrainment_Homo sapiens_hsa047131.08712169
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07377803
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07192183
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.06189188
48Prostate cancer_Homo sapiens_hsa052151.04481607
49Calcium signaling pathway_Homo sapiens_hsa040201.03189306
50RNA degradation_Homo sapiens_hsa030181.02767181
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.02531134
52Spliceosome_Homo sapiens_hsa030401.01238942
53Aldosterone synthesis and secretion_Homo sapiens_hsa049251.00496181
54Hedgehog signaling pathway_Homo sapiens_hsa043401.00265063
55Hippo signaling pathway_Homo sapiens_hsa043901.00187709
56Regulation of actin cytoskeleton_Homo sapiens_hsa048100.99093133
57Serotonergic synapse_Homo sapiens_hsa047260.98892331
58Axon guidance_Homo sapiens_hsa043600.98815618
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98420075
60Renal cell carcinoma_Homo sapiens_hsa052110.98250824
61Acute myeloid leukemia_Homo sapiens_hsa052210.97486800
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.96904884
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.96209288
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95961360
65Dorso-ventral axis formation_Homo sapiens_hsa043200.95644993
66Insulin secretion_Homo sapiens_hsa049110.94752350
67Choline metabolism in cancer_Homo sapiens_hsa052310.94030260
68Adherens junction_Homo sapiens_hsa045200.93848991
69Pathways in cancer_Homo sapiens_hsa052000.93184733
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92156738
71Circadian rhythm_Homo sapiens_hsa047100.91436861
72Proteoglycans in cancer_Homo sapiens_hsa052050.90235541
73Rap1 signaling pathway_Homo sapiens_hsa040150.87658304
74Colorectal cancer_Homo sapiens_hsa052100.87167151
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86717773
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84689957
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83092770
78Arachidonic acid metabolism_Homo sapiens_hsa005900.82577435
79Homologous recombination_Homo sapiens_hsa034400.82186787
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81553417
81AMPK signaling pathway_Homo sapiens_hsa041520.81267308
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81233979
83Dilated cardiomyopathy_Homo sapiens_hsa054140.80231423
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79961428
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79587139
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78918123
87VEGF signaling pathway_Homo sapiens_hsa043700.78650170
88Prolactin signaling pathway_Homo sapiens_hsa049170.77902735
89Small cell lung cancer_Homo sapiens_hsa052220.77421141
90Oocyte meiosis_Homo sapiens_hsa041140.76792945
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.76609646
92Base excision repair_Homo sapiens_hsa034100.76003132
93Pancreatic cancer_Homo sapiens_hsa052120.75927272
94p53 signaling pathway_Homo sapiens_hsa041150.75749486
95Wnt signaling pathway_Homo sapiens_hsa043100.75398055
96Nicotine addiction_Homo sapiens_hsa050330.75250622
97HTLV-I infection_Homo sapiens_hsa051660.75151866
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74837677
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74652512
100Endometrial cancer_Homo sapiens_hsa052130.72869517
101Long-term potentiation_Homo sapiens_hsa047200.72728748
102Systemic lupus erythematosus_Homo sapiens_hsa053220.72392379
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.71522631
104Platelet activation_Homo sapiens_hsa046110.69151531
105Estrogen signaling pathway_Homo sapiens_hsa049150.67189713
106Bladder cancer_Homo sapiens_hsa052190.66374169
107Linoleic acid metabolism_Homo sapiens_hsa005910.65548531
108Gastric acid secretion_Homo sapiens_hsa049710.65251192
109Ovarian steroidogenesis_Homo sapiens_hsa049130.65033639
110Chronic myeloid leukemia_Homo sapiens_hsa052200.64690530
111Viral carcinogenesis_Homo sapiens_hsa052030.64530256
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64427754
113Herpes simplex infection_Homo sapiens_hsa051680.63860126
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63451774
115GnRH signaling pathway_Homo sapiens_hsa049120.62825884
116Melanogenesis_Homo sapiens_hsa049160.61275601
117Tight junction_Homo sapiens_hsa045300.60546204
118Intestinal immune network for IgA production_Homo sapiens_hsa046720.59945156
119Insulin resistance_Homo sapiens_hsa049310.58501408
120Glioma_Homo sapiens_hsa052140.58294408
121T cell receptor signaling pathway_Homo sapiens_hsa046600.56123433
122NF-kappa B signaling pathway_Homo sapiens_hsa040640.56054546
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.56019229
124cAMP signaling pathway_Homo sapiens_hsa040240.52062320
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51377601
126B cell receptor signaling pathway_Homo sapiens_hsa046620.50545743
127MAPK signaling pathway_Homo sapiens_hsa040100.49852075
128Focal adhesion_Homo sapiens_hsa045100.49790917
129ErbB signaling pathway_Homo sapiens_hsa040120.49299486
130Glutamatergic synapse_Homo sapiens_hsa047240.48930694
131Non-homologous end-joining_Homo sapiens_hsa034500.48708301
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48585443
133Leukocyte transendothelial migration_Homo sapiens_hsa046700.47118467
134Oxytocin signaling pathway_Homo sapiens_hsa049210.46485313
135RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43643570
136HIF-1 signaling pathway_Homo sapiens_hsa040660.42898591
137Taste transduction_Homo sapiens_hsa047420.42682446
138Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42565500
139Primary immunodeficiency_Homo sapiens_hsa053400.42265214
140Apoptosis_Homo sapiens_hsa042100.41906616
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39712257
142Long-term depression_Homo sapiens_hsa047300.37886200
143Ras signaling pathway_Homo sapiens_hsa040140.37576935
144Biosynthesis of amino acids_Homo sapiens_hsa012300.37543595

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