GOLT1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.17249753
2L-phenylalanine catabolic process (GO:0006559)7.17249753
3L-phenylalanine metabolic process (GO:0006558)6.93852766
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.93852766
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.58909874
6epoxygenase P450 pathway (GO:0019373)6.37155346
7aromatic amino acid family catabolic process (GO:0009074)6.22711527
8high-density lipoprotein particle remodeling (GO:0034375)5.60491547
9indole-containing compound catabolic process (GO:0042436)5.39320229
10indolalkylamine catabolic process (GO:0046218)5.39320229
11tryptophan catabolic process (GO:0006569)5.39320229
12urea metabolic process (GO:0019627)5.38267587
13urea cycle (GO:0000050)5.38267587
14kynurenine metabolic process (GO:0070189)5.25958343
15glyoxylate metabolic process (GO:0046487)5.25669255
16regulation of cholesterol esterification (GO:0010872)5.24872131
17regulation of triglyceride catabolic process (GO:0010896)5.15950331
18tryptophan metabolic process (GO:0006568)5.15636818
19bile acid biosynthetic process (GO:0006699)5.15205299
20cysteine metabolic process (GO:0006534)5.14823011
21phenylpropanoid metabolic process (GO:0009698)5.09390862
22sulfur amino acid catabolic process (GO:0000098)5.07454428
23reverse cholesterol transport (GO:0043691)5.06636509
24alpha-linolenic acid metabolic process (GO:0036109)5.06023885
25omega-hydroxylase P450 pathway (GO:0097267)5.05201672
26phospholipid efflux (GO:0033700)5.01669323
27nitrogen cycle metabolic process (GO:0071941)4.95813780
28intestinal cholesterol absorption (GO:0030299)4.90582515
29negative regulation of fibrinolysis (GO:0051918)4.82707302
30protein carboxylation (GO:0018214)4.81129307
31peptidyl-glutamic acid carboxylation (GO:0017187)4.81129307
32protein-lipid complex remodeling (GO:0034368)4.79438968
33macromolecular complex remodeling (GO:0034367)4.79438968
34plasma lipoprotein particle remodeling (GO:0034369)4.79438968
35homocysteine metabolic process (GO:0050667)4.74602930
36negative regulation of cholesterol transport (GO:0032375)4.72752818
37negative regulation of sterol transport (GO:0032372)4.72752818
38acylglycerol homeostasis (GO:0055090)4.66189527
39triglyceride homeostasis (GO:0070328)4.66189527
40serine family amino acid catabolic process (GO:0009071)4.66151305
41regulation of fibrinolysis (GO:0051917)4.63306785
42bile acid metabolic process (GO:0008206)4.63260177
43blood coagulation, intrinsic pathway (GO:0007597)4.60303195
44aromatic amino acid family metabolic process (GO:0009072)4.59189980
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.52605243
46cholesterol efflux (GO:0033344)4.50536481
47tyrosine metabolic process (GO:0006570)4.47074474
48complement activation, alternative pathway (GO:0006957)4.44189547
49drug catabolic process (GO:0042737)4.43087075
50regulation of protein activation cascade (GO:2000257)4.40777144
51lysine catabolic process (GO:0006554)4.40775297
52lysine metabolic process (GO:0006553)4.40775297
53plasma lipoprotein particle assembly (GO:0034377)4.39132969
54ethanol oxidation (GO:0006069)4.33644053
55bile acid and bile salt transport (GO:0015721)4.33310968
56positive regulation of lipoprotein lipase activity (GO:0051006)4.33240532
57positive regulation of triglyceride lipase activity (GO:0061365)4.33240532
58amino-acid betaine metabolic process (GO:0006577)4.30948082
59cellular ketone body metabolic process (GO:0046950)4.28015842
60alpha-amino acid catabolic process (GO:1901606)4.21122950
61intestinal absorption (GO:0050892)4.20517580
62regulation of bile acid biosynthetic process (GO:0070857)4.17900777
63negative regulation of protein activation cascade (GO:2000258)4.16884791
64plasma lipoprotein particle clearance (GO:0034381)4.14193678
65regulation of complement activation (GO:0030449)4.08429115
66regulation of plasminogen activation (GO:0010755)4.05963352
67fructose metabolic process (GO:0006000)3.97951745
68very-low-density lipoprotein particle assembly (GO:0034379)3.96651811
69flavonoid metabolic process (GO:0009812)3.95738149
70regulation of cholesterol homeostasis (GO:2000188)3.94083147
71protein-lipid complex assembly (GO:0065005)3.93854153
72oxidative demethylation (GO:0070989)3.93843753
73acute-phase response (GO:0006953)3.93830694
74lipoprotein metabolic process (GO:0042157)3.93757970
75cellular amino acid catabolic process (GO:0009063)3.93619771
76cellular modified amino acid catabolic process (GO:0042219)3.92584630
77indolalkylamine metabolic process (GO:0006586)3.91849315
78glutamate metabolic process (GO:0006536)3.90257542
79heme transport (GO:0015886)3.90157852
80cholesterol homeostasis (GO:0042632)3.89725144
81coenzyme catabolic process (GO:0009109)3.87257488
82cellular glucuronidation (GO:0052695)3.86524414
83negative regulation of blood coagulation (GO:0030195)3.86258430
84negative regulation of hemostasis (GO:1900047)3.86258430
85sterol homeostasis (GO:0055092)3.84102983
86glycine metabolic process (GO:0006544)3.79570879
87arginine metabolic process (GO:0006525)3.78951007
88plasma lipoprotein particle organization (GO:0071827)3.76492895
89regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.76115903
90serine family amino acid metabolic process (GO:0009069)3.76071264
91benzene-containing compound metabolic process (GO:0042537)3.72788537
92amine catabolic process (GO:0009310)3.71600710
93cellular biogenic amine catabolic process (GO:0042402)3.71600710
94positive regulation of lipid catabolic process (GO:0050996)3.69641920
95ketone body metabolic process (GO:1902224)3.68817354
96drug transmembrane transport (GO:0006855)3.67607686
97phospholipid homeostasis (GO:0055091)3.66545450
98imidazole-containing compound metabolic process (GO:0052803)3.64271887
99polyketide metabolic process (GO:0030638)3.61962988
100doxorubicin metabolic process (GO:0044598)3.61962988
101daunorubicin metabolic process (GO:0044597)3.61962988
102negative regulation of complement activation (GO:0045916)3.61686162
103negative regulation of coagulation (GO:0050819)3.61146846
104ethanol metabolic process (GO:0006067)3.61091175
105drug metabolic process (GO:0017144)3.60206614
106protein activation cascade (GO:0072376)3.59078104
107xenobiotic catabolic process (GO:0042178)3.58123240
108negative regulation of wound healing (GO:0061045)3.56034920
109negative regulation of lipase activity (GO:0060192)3.54338065
110protein-lipid complex subunit organization (GO:0071825)3.54243264
111exogenous drug catabolic process (GO:0042738)3.53233630
112organic acid catabolic process (GO:0016054)3.51965416
113carboxylic acid catabolic process (GO:0046395)3.51965416
114serine family amino acid biosynthetic process (GO:0009070)3.51884962
115low-density lipoprotein particle remodeling (GO:0034374)3.50479489
116aldehyde catabolic process (GO:0046185)3.49559583
117uronic acid metabolic process (GO:0006063)3.45963066
118glucuronate metabolic process (GO:0019585)3.45963066
119positive regulation of fatty acid biosynthetic process (GO:0045723)3.45473023
120dicarboxylic acid biosynthetic process (GO:0043650)3.45271120
121short-chain fatty acid metabolic process (GO:0046459)3.43846530
122fibrinolysis (GO:0042730)3.42050381
123alkaloid metabolic process (GO:0009820)3.41317911
124complement activation, classical pathway (GO:0006958)3.39053247
125proline metabolic process (GO:0006560)3.38641633
126hormone catabolic process (GO:0042447)3.37634667
127urate metabolic process (GO:0046415)3.36205867
128fat-soluble vitamin biosynthetic process (GO:0042362)3.28987214
129L-ascorbic acid metabolic process (GO:0019852)3.26132900
130regulation of humoral immune response (GO:0002920)3.25628273
131complement activation (GO:0006956)3.23397467
132NADH metabolic process (GO:0006734)3.19242889

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.03887962
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.98077938
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.47483214
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.29613121
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.96927658
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.91859834
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.55373123
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.83187322
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.77995472
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.53902194
11* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.51662290
12GATA1_22025678_ChIP-Seq_K562_Human2.04874745
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.2574747
14* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.94106194
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93638911
16SOX2_27498859_Chip-Seq_STOMACH_Mouse1.72893617
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69185975
18CLOCK_20551151_ChIP-Seq_293T_Human1.66965166
19* FOXA2_19822575_ChIP-Seq_HepG2_Human1.64685028
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.57712828
21HNF4A_19822575_ChIP-Seq_HepG2_Human1.55790861
22GATA4_25053715_ChIP-Seq_YYC3_Human1.44127082
23ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.39811722
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.33281701
25HTT_18923047_ChIP-ChIP_STHdh_Human1.33277241
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25579818
27PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19569192
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19019960
29CDX2_20551321_ChIP-Seq_CACO-2_Human1.18752275
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12365790
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10859880
32RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09534088
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09197476
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03960261
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02540592
36CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00446701
37TP63_17297297_ChIP-ChIP_HaCaT_Human0.96465475
38TCF4_18268006_ChIP-ChIP_LS174T_Human0.95739874
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95675798
40TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95279804
41GATA6_25053715_ChIP-Seq_YYC3_Human0.94767798
42AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92662074
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92390621
44HIF1A_21447827_ChIP-Seq_MCF-7_Human0.90562432
45BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88654371
46IRF8_22096565_ChIP-ChIP_GC-B_Human0.87764733
47SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85594028
48* SOX2_20726797_ChIP-Seq_SW620_Human0.84520229
49RARA_24833708_ChIP-Seq_LIVER_Mouse0.84359030
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.83875999
51FOXA1_25329375_ChIP-Seq_VCAP_Human0.83437392
52FOXA1_27270436_Chip-Seq_PROSTATE_Human0.83437392
53SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.83107807
54KAP1_22055183_ChIP-Seq_ESCs_Mouse0.83029478
55NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.81464817
56* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.80549701
57* NFE2_27457419_Chip-Seq_LIVER_Mouse0.79955824
58FOXA1_25552417_ChIP-Seq_VCAP_Human0.79628138
59* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.79152618
60ESR2_21235772_ChIP-Seq_MCF-7_Human0.77726596
61SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77312116
62PIAS1_25552417_ChIP-Seq_VCAP_Human0.77268119
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.75409919
64FOXA1_21572438_ChIP-Seq_LNCaP_Human0.74645263
65RARG_19884340_ChIP-ChIP_MEFs_Mouse0.73116093
66PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.73008012
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.72184550
68ER_23166858_ChIP-Seq_MCF-7_Human0.69624182
69SUZ12_27294783_Chip-Seq_NPCs_Mouse0.69285752
70AUTS2_25519132_ChIP-Seq_293T-REX_Human0.69136551
71PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.68980930
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.68908048
73NCOR_22424771_ChIP-Seq_293T_Human0.68624489
74FOXM1_26456572_ChIP-Seq_MCF-7_Human0.68312457
75MYC_19829295_ChIP-Seq_ESCs_Human0.68022547
76RARB_24833708_ChIP-Seq_LIVER_Mouse0.67776520
77POU3F2_20337985_ChIP-ChIP_501MEL_Human0.67565115
78BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.67475086
79ESR1_21235772_ChIP-Seq_MCF-7_Human0.67373782
80AR_20517297_ChIP-Seq_VCAP_Human0.66421305
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.66107390
82* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.66101427
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.65645666
84* GATA3_21867929_ChIP-Seq_CD8_Mouse0.65560270
85TRIM28_21343339_ChIP-Seq_HEK293_Human0.65485664
86PHF8_20622853_ChIP-Seq_HELA_Human0.64441307
87* SOX2_21211035_ChIP-Seq_LN229_Human0.64140285
88TCF4_22108803_ChIP-Seq_LS180_Human0.63954996
89* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.62776406
90* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.61971250
91* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61896468
92KLF5_20875108_ChIP-Seq_MESCs_Mouse0.61751317
93LXR_22292898_ChIP-Seq_THP-1_Human0.61109180
94HNFA_21074721_ChIP-Seq_CACO-2_Human0.60711158
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.60573893
96GBX2_23144817_ChIP-Seq_PC3_Human0.60473275
97* STAT3_18555785_Chip-Seq_ESCs_Mouse0.59796620
98* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.59791656
99* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.59749279
100PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.59647008
101* ZFX_18555785_Chip-Seq_ESCs_Mouse0.59502394
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.58618448
103NRF2_20460467_ChIP-Seq_MEFs_Mouse0.57585931
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.57585931
105FOXO3_23340844_ChIP-Seq_DLD1_Human0.57221939
106PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.57015957
107GATA3_24758297_ChIP-Seq_MCF-7_Human0.56348226
108FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.56274387
109ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.55118423
110ZNF263_19887448_ChIP-Seq_K562_Human0.54435524
111CEBPB_22108803_ChIP-Seq_LS180_Human0.53772956
112Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.53699550
113MYC_19915707_ChIP-ChIP_AK7_Human0.53675517
114ESR1_15608294_ChIP-ChIP_MCF-7_Human0.53295711
115CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.53245651
116P53_21459846_ChIP-Seq_SAOS-2_Human0.52538419
117GATA1_19941826_ChIP-Seq_K562_Human0.52492129
118SRY_22984422_ChIP-ChIP_TESTIS_Rat0.51459190
119GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.51244739
120ERG_20517297_ChIP-Seq_VCAP_Human0.51233643
121CBP_21632823_ChIP-Seq_H3396_Human0.51021905
122* GATA2_19941826_ChIP-Seq_K562_Human0.50697914
123NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.50502819
124* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.50417982
125ESET_19884257_ChIP-Seq_ESCs_Mouse0.49366687
126STAT3_1855785_ChIP-Seq_MESCs_Mouse0.48977543
127* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.48560906
128STAT1_17558387_ChIP-Seq_HELA_Human0.47558522
129ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.45412512
130EGR1_19032775_ChIP-ChIP_M12_Human0.44033711
131CDX2_22108803_ChIP-Seq_LS180_Human0.44025030
132RACK7_27058665_Chip-Seq_MCF-7_Human0.43909173
133TAF2_19829295_ChIP-Seq_ESCs_Human0.43481935
134TET1_21451524_ChIP-Seq_MESCs_Mouse0.43375890
135SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.42462603
136BCAT_22108803_ChIP-Seq_LS180_Human0.41357785
137SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.41283143

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.05032318
2MP0005360_urolithiasis7.88436255
3MP0005085_abnormal_gallbladder_physiolo6.01145207
4MP0005365_abnormal_bile_salt5.72194172
5MP0008875_abnormal_xenobiotic_pharmacok4.84636885
6MP0003252_abnormal_bile_duct3.99882907
7MP0003806_abnormal_nucleotide_metabolis3.66838813
8MP0009840_abnormal_foam_cell3.52745452
9MP0010329_abnormal_lipoprotein_level3.47267925
10MP0001666_abnormal_nutrient_absorption3.45165685
11MP0003195_calcinosis2.87184079
12MP0005332_abnormal_amino_acid2.77952091
13MP0005083_abnormal_biliary_tract2.47597135
14MP0004019_abnormal_vitamin_homeostasis2.43156246
15MP0002138_abnormal_hepatobiliary_system2.31355448
16MP0003191_abnormal_cellular_cholesterol2.20793231
17MP0000609_abnormal_liver_physiology2.04166597
18MP0002118_abnormal_lipid_homeostasis2.03530090
19MP0003868_abnormal_feces_composition1.93638526
20MP0001764_abnormal_homeostasis1.79945000
21MP0009697_abnormal_copulation1.72632549
22MP0005319_abnormal_enzyme/_coenzyme1.69062928
23MP0009643_abnormal_urine_homeostasis1.59403566
24MP0005451_abnormal_body_composition1.43070792
25MP0003879_abnormal_hair_cell1.38389091
26MP0005584_abnormal_enzyme/coenzyme_acti1.36140054
27MP0005084_abnormal_gallbladder_morpholo1.26394712
28MP0003122_maternal_imprinting1.26092448
29MP0005636_abnormal_mineral_homeostasis1.21585560
30MP0004043_abnormal_pH_regulation1.17898214
31MP0000566_synostosis1.10798463
32MP0005220_abnormal_exocrine_pancreas1.10084620
33MP0004264_abnormal_extraembryonic_tissu1.07052015
34MP0003186_abnormal_redox_activity1.06434736
35MP0000598_abnormal_liver_morphology1.05405118
36MP0003656_abnormal_erythrocyte_physiolo1.04789164
37MP0003123_paternal_imprinting1.02167430
38MP0002078_abnormal_glucose_homeostasis1.02043333
39MP0001756_abnormal_urination1.01235745
40MP0003011_delayed_dark_adaptation0.98191582
41MP0002876_abnormal_thyroid_physiology0.97793111
42MP0003183_abnormal_peptide_metabolism0.97706421
43MP0003705_abnormal_hypodermis_morpholog0.92075349
44MP0009642_abnormal_blood_homeostasis0.91664870
45MP0005408_hypopigmentation0.91517425
46MP0009764_decreased_sensitivity_to0.90143998
47MP0002254_reproductive_system_inflammat0.87430652
48MP0000604_amyloidosis0.86784852
49MP0005647_abnormal_sex_gland0.86174702
50MP0010234_abnormal_vibrissa_follicle0.83944100
51MP0006036_abnormal_mitochondrial_physio0.80335492
52MP0009763_increased_sensitivity_to0.79174165
53MP0008469_abnormal_protein_level0.78576135
54MP0005376_homeostasis/metabolism_phenot0.76666839
55MP0005448_abnormal_energy_balance0.76568953
56MP0009765_abnormal_xenobiotic_induced0.74441078
57MP0001984_abnormal_olfaction0.73722201
58MP0005670_abnormal_white_adipose0.73655767
59MP0003300_gastrointestinal_ulcer0.71711445
60MP0005535_abnormal_body_temperature0.71304452
61MP0005334_abnormal_fat_pad0.68146461
62MP0002089_abnormal_postnatal_growth/wei0.66485432
63MP0001765_abnormal_ion_homeostasis0.66014622
64MP0001944_abnormal_pancreas_morphology0.65878355
65MP0002928_abnormal_bile_duct0.65724512
66MP0002136_abnormal_kidney_physiology0.65257764
67MP0002132_abnormal_respiratory_system0.65163969
68MP0002822_catalepsy0.65139861
69MP0004270_analgesia0.64886643
70MP0002971_abnormal_brown_adipose0.63928674
71MP0002837_dystrophic_cardiac_calcinosis0.63730491
72MP0000003_abnormal_adipose_tissue0.62709322
73MP0005266_abnormal_metabolism0.61287648
74MP0000462_abnormal_digestive_system0.61063255
75MP0000538_abnormal_urinary_bladder0.60043194
76MP0003953_abnormal_hormone_level0.59403133
77MP0002090_abnormal_vision0.56890479
78MP0005367_renal/urinary_system_phenotyp0.56133904
79MP0000516_abnormal_urinary_system0.56133904
80MP0003718_maternal_effect0.55987191
81MP0009780_abnormal_chondrocyte_physiolo0.55955287
82MP0005379_endocrine/exocrine_gland_phen0.55578051
83MP0002693_abnormal_pancreas_physiology0.53911772
84MP0000639_abnormal_adrenal_gland0.51946563
85MP0009046_muscle_twitch0.51577251
86MP0003638_abnormal_response/metabolism_0.50876912
87MP0005645_abnormal_hypothalamus_physiol0.50858365
88MP0000230_abnormal_systemic_arterial0.50301896
89MP0009053_abnormal_anal_canal0.50182816
90MP0005395_other_phenotype0.49071932
91MP0005646_abnormal_pituitary_gland0.48955478
92MP0004782_abnormal_surfactant_physiolog0.47865859
93MP0005058_abnormal_lysosome_morphology0.47267933
94MP0001664_abnormal_digestion0.45936438
95MP0001661_extended_life_span0.45462782
96MP0005410_abnormal_fertilization0.44637641
97MP0010368_abnormal_lymphatic_system0.44330442
98MP0003329_amyloid_beta_deposits0.43707601
99MP0002796_impaired_skin_barrier0.42933700
100MP0006035_abnormal_mitochondrial_morpho0.42252817
101MP0008873_increased_physiological_sensi0.40198523
102MP0002163_abnormal_gland_morphology0.40014001
103MP0005666_abnormal_adipose_tissue0.39903721
104MP0003172_abnormal_lysosome_physiology0.39866803
105MP0004147_increased_porphyrin_level0.37661758
106MP0005248_abnormal_Harderian_gland0.36796396
107MP0008874_decreased_physiological_sensi0.36039925
108MP0005464_abnormal_platelet_physiology0.35873534
109MP0002069_abnormal_eating/drinking_beha0.35797075
110MP0004130_abnormal_muscle_cell0.35465100
111MP0005551_abnormal_eye_electrophysiolog0.34994858
112MP0010386_abnormal_urinary_bladder0.34811640
113MP0008872_abnormal_physiological_respon0.34662018
114MP0003941_abnormal_skin_development0.34535553
115MP0001501_abnormal_sleep_pattern0.33138118
116MP0000013_abnormal_adipose_tissue0.32736491
117MP0009115_abnormal_fat_cell0.32282358
118MP0003690_abnormal_glial_cell0.32204521
119MP0002909_abnormal_adrenal_gland0.31023087
120MP0005166_decreased_susceptibility_to0.30591325
121MP0005381_digestive/alimentary_phenotyp0.30508803
122MP0001845_abnormal_inflammatory_respons0.29959702
123MP0008961_abnormal_basal_metabolism0.28746257
124MP0009384_cardiac_valve_regurgitation0.26914518
125MP0003959_abnormal_lean_body0.26896247

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.21880105
2Intrahepatic cholestasis (HP:0001406)6.54974424
3Hypobetalipoproteinemia (HP:0003563)6.36395835
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.20195855
5Deep venous thrombosis (HP:0002625)6.13886724
6Xanthomatosis (HP:0000991)5.83506715
7Prolonged partial thromboplastin time (HP:0003645)5.75575983
8Abnormality of glutamine family amino acid metabolism (HP:0010902)4.68741702
9Hyperlipoproteinemia (HP:0010980)4.65488305
10Hypolipoproteinemia (HP:0010981)4.59617054
11Hypoglycemic coma (HP:0001325)4.53459863
12Hyperammonemia (HP:0001987)4.27883262
13Ketosis (HP:0001946)4.24915575
14Abnormality of sulfur amino acid metabolism (HP:0004339)4.22823800
15Complement deficiency (HP:0004431)4.20722212
16Conjugated hyperbilirubinemia (HP:0002908)4.18950736
17Abnormality of aspartate family amino acid metabolism (HP:0010899)4.15927207
18Abnormality of the common coagulation pathway (HP:0010990)4.15133569
19Fat malabsorption (HP:0002630)4.14750256
20Epidermoid cyst (HP:0200040)4.09837672
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.07635510
22Hyperglycinuria (HP:0003108)4.07488723
23Joint hemorrhage (HP:0005261)4.01833418
24Hyperglycinemia (HP:0002154)3.97306808
25Abnormality of the intrinsic pathway (HP:0010989)3.92109963
26Abnormality of serine family amino acid metabolism (HP:0010894)3.82232588
27Abnormality of glycine metabolism (HP:0010895)3.82232588
28Abnormality of methionine metabolism (HP:0010901)3.80002232
29Hypoalphalipoproteinemia (HP:0003233)3.73327701
30Ketoacidosis (HP:0001993)3.61463815
31Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.43606186
32Hypercholesterolemia (HP:0003124)3.40719530
33Hypoglycemic seizures (HP:0002173)3.39050174
34Abnormality of fatty-acid metabolism (HP:0004359)3.35288876
35Abnormality of pyrimidine metabolism (HP:0004353)3.25729571
36Hyperbilirubinemia (HP:0002904)3.24189839
37Abnormality of nucleobase metabolism (HP:0010932)3.17913046
38Abnormality of purine metabolism (HP:0004352)3.14004784
39Gout (HP:0001997)3.11257961
40Hyperinsulinemic hypoglycemia (HP:0000825)3.08689491
41Abnormality of complement system (HP:0005339)3.04197058
42Acanthocytosis (HP:0001927)3.02548827
43Metabolic acidosis (HP:0001942)2.97213857
44Symptomatic seizures (HP:0011145)2.86511261
45Skin nodule (HP:0200036)2.82219581
46Late onset (HP:0003584)2.79886353
47Abnormal urine phosphate concentration (HP:0012599)2.77738869
48Abnormality of serum amino acid levels (HP:0003112)2.74928650
49Malnutrition (HP:0004395)2.74546934
50Steatorrhea (HP:0002570)2.73409484
51Delayed CNS myelination (HP:0002188)2.72449939
52Dicarboxylic aciduria (HP:0003215)2.68749137
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.68749137
54Hepatocellular carcinoma (HP:0001402)2.68074554
55Lethargy (HP:0001254)2.59140150
56Irritability (HP:0000737)2.56677310
57Abnormality of urine glucose concentration (HP:0011016)2.53328858
58Glycosuria (HP:0003076)2.53328858
59Generalized aminoaciduria (HP:0002909)2.52343511
60Abnormality of vitamin B metabolism (HP:0004340)2.50536833
61Hyperglycemia (HP:0003074)2.47253497
62Spontaneous abortion (HP:0005268)2.43886668
63Hydroxyprolinuria (HP:0003080)2.43223606
64Abnormality of proline metabolism (HP:0010907)2.43223606
65Vascular calcification (HP:0004934)2.39475330
66Nephritis (HP:0000123)2.38563672
67Abnormal gallbladder morphology (HP:0012437)2.38321419
68Gingival bleeding (HP:0000225)2.36041740
69Proximal tubulopathy (HP:0000114)2.34377619
70Facial shape deformation (HP:0011334)2.32804729
71Potter facies (HP:0002009)2.32804729
72Myocardial infarction (HP:0001658)2.29456403
73Systemic lupus erythematosus (HP:0002725)2.25964092
74Abnormality of vitamin metabolism (HP:0100508)2.24796338
75Hypophosphatemic rickets (HP:0004912)2.24434984
76Hypochromic microcytic anemia (HP:0004840)2.24391268
77Pancreatitis (HP:0001733)2.24244984
78Widely patent fontanelles and sutures (HP:0004492)2.22770743
79Cholelithiasis (HP:0001081)2.22634616
80Brushfield spots (HP:0001088)2.17967860
81Osteomalacia (HP:0002749)2.16471143
82Cerebral edema (HP:0002181)2.16051730
83Abnormal gallbladder physiology (HP:0012438)2.14863751
84Cholecystitis (HP:0001082)2.14863751
85Enlarged kidneys (HP:0000105)2.14844592
86Alkalosis (HP:0001948)2.14159529
87Poikilocytosis (HP:0004447)2.13724570
88Reduced antithrombin III activity (HP:0001976)2.12734803
89Hypothermia (HP:0002045)2.10516418
90Sensorimotor neuropathy (HP:0007141)2.10443718
91Cardiovascular calcification (HP:0011915)2.08457802
92Vomiting (HP:0002013)2.08077801
93Ileus (HP:0002595)2.07168148
94Glomerulonephritis (HP:0000099)2.06087189
95Hyperuricemia (HP:0002149)2.05299128
96Increased purine levels (HP:0004368)2.05299128
97Amyloidosis (HP:0011034)2.03939718
98Rickets (HP:0002748)2.03674213
99Acute encephalopathy (HP:0006846)2.00206591
100Abnormality of the pancreatic islet cells (HP:0006476)1.99795348
101Abnormality of endocrine pancreas physiology (HP:0012093)1.99795348
102Esophageal varix (HP:0002040)1.99234429
103Spastic diplegia (HP:0001264)1.98666082
104Mitral stenosis (HP:0001718)1.96541601
105Abnormal enzyme/coenzyme activity (HP:0012379)1.95491611
106Abnormality of the gallbladder (HP:0005264)1.95424577
107Hyperphosphaturia (HP:0003109)1.94937777
108Hemorrhage of the eye (HP:0011885)1.94743115
109Menorrhagia (HP:0000132)1.94504897
110Hypotension (HP:0002615)1.91023310
111Hypophosphatemia (HP:0002148)1.90912958
112Abnormality of the vitamin B12 metabolism (HP:0004341)1.90733406
113Abnormality of transition element cation homeostasis (HP:0011030)1.89703081
114Neonatal onset (HP:0003623)1.89462228
115Nephrolithiasis (HP:0000787)1.89364260
116Postural tremor (HP:0002174)1.89248441
117Increased serum pyruvate (HP:0003542)1.88909469
118Opisthotonus (HP:0002179)1.87962942
119Recurrent gram-negative bacterial infections (HP:0005420)1.84386513
120Megaloblastic anemia (HP:0001889)1.82284621
121Abnormality of glycolysis (HP:0004366)1.81936975
122Renal tubular dysfunction (HP:0000124)1.81561299
123Mucopolysacchariduria (HP:0008155)1.77958689
124Urinary glycosaminoglycan excretion (HP:0003541)1.77958689

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.81986013
2MAP3K124.72651574
3FRK4.52713003
4INSRR4.51922048
5ERN14.38285585
6FGFR43.74882147
7SIK13.42099190
8MAP3K93.24777926
9TAOK33.22883497
10MST1R2.88521706
11MAPK152.76852137
12PIK3CG2.30605087
13FGFR32.30560020
14ACVR1B2.25738448
15SCYL22.21314090
16ERBB42.00778273
17PTK61.94732969
18TESK11.85327853
19AKT31.74744109
20FLT31.70700940
21WNK31.69823753
22NTRK31.53816256
23MAPK111.47173205
24LATS11.40038279
25GRK61.39115364
26MAP3K21.38889266
27MET1.38003944
28PKN21.36820347
29TRIB31.35352159
30STK38L1.34335056
31WNK41.31899131
32STK391.31699476
33IRAK31.29297767
34MAP2K41.29282967
35PRKG21.23692337
36ARAF1.23203418
37MAP2K21.20845960
38PAK41.20414340
39EPHA21.19361395
40DYRK1B1.18179132
41MAP3K31.12721432
42CAMK2D1.12069115
43PRKAA21.10442389
44TYK21.08848269
45PTK21.05287111
46PHKG21.04551618
47PHKG11.04551618
48RIPK11.03793263
49CSNK1G11.03104605
50LIMK10.99725917
51LMTK20.97585719
52JAK20.96785420
53CASK0.96014636
54PRKCI0.93532467
55DAPK10.93270846
56EIF2AK10.92159808
57PRKCE0.91135803
58DAPK20.90529864
59PRKAA10.90027000
60MAP3K110.88587882
61MAP3K100.88194416
62OXSR10.87729601
63CSNK1G30.87197679
64PINK10.84595626
65MUSK0.82926525
66ERBB20.80978311
67MAP2K60.78595903
68GRK50.76038481
69TAOK10.75034428
70NUAK10.74444225
71PBK0.74122036
72ABL20.74035978
73JAK10.70135672
74PAK30.69658596
75PRKACG0.68513552
76PRKCZ0.67544706
77NLK0.66417074
78TRPM70.65638083
79CAMK2G0.65588894
80NEK90.65252833
81PDPK10.64852784
82PRKG10.64668574
83TBK10.64483652
84MAP3K70.64380662
85MAP3K10.64305536
86TNK20.63553529
87CSNK1E0.60944586
88GSK3A0.60613004
89EPHB10.60189284
90KDR0.60108165
91PASK0.59808687
92NEK10.59257549
93CSK0.58920606
94TNIK0.58563816
95CSNK1G20.58235772
96GRK10.54110950
97RPS6KB20.53411448
98EPHA30.53175455
99MAP2K10.52706507
100MST40.51970493
101ZAK0.49996070
102PDK20.48156436
103MAPK40.47902657
104CDK60.47876789
105CSNK1D0.47481125
106STK160.46837362
107CSNK1A1L0.46427164
108CSNK2A20.45917450
109STK380.44636638
110FGFR10.44498620
111MAP3K40.43798732
112TTK0.43330866
113FER0.42416657
114AKT20.41401696
115SGK30.40882692
116MAP4K20.39925098
117CAMK2B0.39737539
118MAP2K30.38714082
119STK30.38582595
120PDK10.36343471
121FGFR20.34973553
122PRKCQ0.34404202
123PRKCA0.34392018
124EIF2AK30.31618837
125MTOR0.30720862
126IGF1R0.30660081
127HIPK20.28981997
128MYLK0.28764858
129SGK4940.28686136
130SGK2230.28686136
131MAP3K140.28621677
132PDK40.27969342
133PDK30.27969342
134MAP3K50.25833297
135PIK3CA0.24970885
136ITK0.24390626
137SGK20.23268266
138TESK20.23237364
139PDGFRA0.22561671
140IRAK10.21498011
141TIE10.20746272
142EPHB20.20425833
143CAMK1D0.17421111
144RET0.17128501
145PRKACA0.16419024
146MAPKAPK30.16332880
147PRKCG0.16152631
148CSNK1A10.15242956

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.95231532
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.32361491
3Nitrogen metabolism_Homo sapiens_hsa009103.25059136
4Arginine biosynthesis_Homo sapiens_hsa002203.01087880
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.88371797
6Tryptophan metabolism_Homo sapiens_hsa003802.73783094
7Fatty acid degradation_Homo sapiens_hsa000712.48277943
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.46170548
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.34290762
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.33105111
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.32585343
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.32433418
13Complement and coagulation cascades_Homo sapiens_hsa046102.27434491
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.26401708
15Butanoate metabolism_Homo sapiens_hsa006502.14256488
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.04834668
17Histidine metabolism_Homo sapiens_hsa003402.03494396
18Peroxisome_Homo sapiens_hsa041462.01354698
19Sulfur metabolism_Homo sapiens_hsa009201.99580486
20Fat digestion and absorption_Homo sapiens_hsa049751.97672496
21PPAR signaling pathway_Homo sapiens_hsa033201.84077188
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.76737463
23Caffeine metabolism_Homo sapiens_hsa002321.76581429
24Chemical carcinogenesis_Homo sapiens_hsa052041.75440896
25Folate biosynthesis_Homo sapiens_hsa007901.75118490
26Selenocompound metabolism_Homo sapiens_hsa004501.71859091
27Propanoate metabolism_Homo sapiens_hsa006401.71751380
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.71339017
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.69523816
30Fatty acid metabolism_Homo sapiens_hsa012121.68891537
31Bile secretion_Homo sapiens_hsa049761.62428822
32beta-Alanine metabolism_Homo sapiens_hsa004101.61395289
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.58397482
34Starch and sucrose metabolism_Homo sapiens_hsa005001.57849701
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56082511
36Retinol metabolism_Homo sapiens_hsa008301.54971214
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.52559131
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52447508
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49240959
40Vitamin digestion and absorption_Homo sapiens_hsa049771.47825970
41Phenylalanine metabolism_Homo sapiens_hsa003601.45089909
42Pyruvate metabolism_Homo sapiens_hsa006201.39850318
43Staphylococcus aureus infection_Homo sapiens_hsa051501.28326163
44Tyrosine metabolism_Homo sapiens_hsa003501.28037626
45ABC transporters_Homo sapiens_hsa020101.25538232
46Fatty acid elongation_Homo sapiens_hsa000621.21724363
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.15852613
48Arginine and proline metabolism_Homo sapiens_hsa003301.11554171
49Biosynthesis of amino acids_Homo sapiens_hsa012301.11445958
50Carbon metabolism_Homo sapiens_hsa012001.10513500
51Steroid biosynthesis_Homo sapiens_hsa001001.08649335
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07945756
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07592315
54Cyanoamino acid metabolism_Homo sapiens_hsa004601.01018379
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93554586
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91145628
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88168515
58Sulfur relay system_Homo sapiens_hsa041220.87596309
59Lysine degradation_Homo sapiens_hsa003100.81367672
60Glycerolipid metabolism_Homo sapiens_hsa005610.80565396
61Glutathione metabolism_Homo sapiens_hsa004800.80531707
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77228009
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75208251
64Vitamin B6 metabolism_Homo sapiens_hsa007500.74753766
65Galactose metabolism_Homo sapiens_hsa000520.70938108
66Pentose phosphate pathway_Homo sapiens_hsa000300.65958777
67Fructose and mannose metabolism_Homo sapiens_hsa000510.65382018
68Metabolic pathways_Homo sapiens_hsa011000.53260568
69One carbon pool by folate_Homo sapiens_hsa006700.51624094
70Sphingolipid metabolism_Homo sapiens_hsa006000.51116847
71Renin-angiotensin system_Homo sapiens_hsa046140.50330562
72Oxidative phosphorylation_Homo sapiens_hsa001900.48587725
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38758978
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38350039
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35489091
76Mineral absorption_Homo sapiens_hsa049780.35108532
77Linoleic acid metabolism_Homo sapiens_hsa005910.32781974
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32712411
79Fatty acid biosynthesis_Homo sapiens_hsa000610.32147122
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.28285237
81Insulin resistance_Homo sapiens_hsa049310.25984106
82Prion diseases_Homo sapiens_hsa050200.23300865
83Ether lipid metabolism_Homo sapiens_hsa005650.20605453
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20439796
85Protein export_Homo sapiens_hsa030600.18446865
86Pancreatic secretion_Homo sapiens_hsa049720.16417897
87Serotonergic synapse_Homo sapiens_hsa047260.15229463
88Parkinsons disease_Homo sapiens_hsa050120.14171536
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.13600523
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13074479
91Protein digestion and absorption_Homo sapiens_hsa049740.12458134
92Glucagon signaling pathway_Homo sapiens_hsa049220.11289784
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.10764690
94Vibrio cholerae infection_Homo sapiens_hsa051100.10539648
95Alzheimers disease_Homo sapiens_hsa050100.10367301
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.06133991
97Thyroid hormone synthesis_Homo sapiens_hsa049180.04427450
98AMPK signaling pathway_Homo sapiens_hsa041520.01073995
99Lysosome_Homo sapiens_hsa04142-0.1618859
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1519355
101Hepatitis C_Homo sapiens_hsa05160-0.1367390
102Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1302605
103Insulin signaling pathway_Homo sapiens_hsa04910-0.1189326
104N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1178988
105Other glycan degradation_Homo sapiens_hsa00511-0.1141696
106Insulin secretion_Homo sapiens_hsa04911-0.1133805
107Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0686120
108Type II diabetes mellitus_Homo sapiens_hsa04930-0.0663842
109Regulation of autophagy_Homo sapiens_hsa04140-0.0655713
110Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0115161

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »