GOLPH3L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is localized at the Golgi stack and may have a regulatory role in Golgi trafficking. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.42882526
2DNA double-strand break processing (GO:0000729)5.17788555
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.54041334
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.54041334
5COPI coating of Golgi vesicle (GO:0048205)4.25984174
6Golgi transport vesicle coating (GO:0048200)4.25984174
7UDP-N-acetylglucosamine metabolic process (GO:0006047)4.22954611
8antigen processing and presentation via MHC class Ib (GO:0002475)4.04740745
9antigen processing and presentation of endogenous antigen (GO:0019883)4.02517170
10ribosomal small subunit assembly (GO:0000028)3.99182226
11hepatocyte apoptotic process (GO:0097284)3.72466301
12positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.69253542
13positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.69253542
14positive regulation of mitotic sister chromatid separation (GO:1901970)3.69253542
15ribosome assembly (GO:0042255)3.68384060
16non-recombinational repair (GO:0000726)3.65225127
17double-strand break repair via nonhomologous end joining (GO:0006303)3.65225127
18axonemal dynein complex assembly (GO:0070286)3.60935551
19transcription from mitochondrial promoter (GO:0006390)3.57572705
20signal peptide processing (GO:0006465)3.55868881
21mitochondrial DNA replication (GO:0006264)3.47569692
22regulation of meiosis I (GO:0060631)3.46882550
23positive regulation of gamma-delta T cell activation (GO:0046645)3.43500567
24positive regulation of histone H3-K4 methylation (GO:0051571)3.41786774
25purine nucleobase biosynthetic process (GO:0009113)3.34786788
26positive regulation of B cell differentiation (GO:0045579)3.33934984
27respiratory chain complex IV assembly (GO:0008535)3.33266244
28regulation of interferon-beta biosynthetic process (GO:0045357)3.32679944
29establishment of integrated proviral latency (GO:0075713)3.32621896
30definitive hemopoiesis (GO:0060216)3.30976967
31proteasome assembly (GO:0043248)3.29122909
32DNA catabolic process, exonucleolytic (GO:0000738)3.24837089
33nuclear pore organization (GO:0006999)3.23974113
34cullin deneddylation (GO:0010388)3.23814795
35fucose catabolic process (GO:0019317)3.19166532
36L-fucose metabolic process (GO:0042354)3.19166532
37L-fucose catabolic process (GO:0042355)3.19166532
38cytochrome complex assembly (GO:0017004)3.18756466
39histone exchange (GO:0043486)3.17489744
40RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.11864132
41mitotic sister chromatid cohesion (GO:0007064)3.11858402
42positive regulation by symbiont of host defense response (GO:0052509)3.11153655
43modulation by symbiont of host defense response (GO:0052031)3.11153655
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.11153655
45modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.11153655
46positive regulation by organism of defense response of other organism involved in symbiotic interact3.11153655
47modulation by symbiont of host immune response (GO:0052553)3.11153655
48protein deneddylation (GO:0000338)3.10789177
49SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.10596829
50negative regulation of DNA-dependent DNA replication (GO:2000104)3.09986580
51positive regulation of chromosome segregation (GO:0051984)3.09729971
52response to X-ray (GO:0010165)3.09328579
53cotranslational protein targeting to membrane (GO:0006613)3.08130894
54regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.06474230
55peptidyl-histidine modification (GO:0018202)3.04297942
56neutrophil activation involved in immune response (GO:0002283)3.03345633
57protein targeting to ER (GO:0045047)3.03004522
58branched-chain amino acid catabolic process (GO:0009083)2.97382245
59rRNA modification (GO:0000154)2.97171815
60DNA ligation (GO:0006266)2.96575565
61mitotic chromosome condensation (GO:0007076)2.95063621
62Arp2/3 complex-mediated actin nucleation (GO:0034314)2.94769095
63mitochondrial RNA metabolic process (GO:0000959)2.93748116
64mitotic spindle checkpoint (GO:0071174)2.92116492
65somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.92104905
66isotype switching (GO:0045190)2.92104905
67somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.92104905
68rRNA catabolic process (GO:0016075)2.91994595
69regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.91812359
70T-helper 1 type immune response (GO:0042088)2.91531748
71DNA replication checkpoint (GO:0000076)2.91221930
72negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.90013391
73immunoglobulin mediated immune response (GO:0016064)2.89683085
74terpenoid biosynthetic process (GO:0016114)2.88562692
75spindle checkpoint (GO:0031577)2.88186248
76protein localization to endoplasmic reticulum (GO:0070972)2.87967271
77establishment of protein localization to endoplasmic reticulum (GO:0072599)2.87948996
78IMP biosynthetic process (GO:0006188)2.86939430
79regulation of RIG-I signaling pathway (GO:0039535)2.86680089
80mitotic recombination (GO:0006312)2.85840636
81positive regulation of interferon-alpha production (GO:0032727)2.84491206
82nucleotide-sugar biosynthetic process (GO:0009226)2.84331474
83somatic hypermutation of immunoglobulin genes (GO:0016446)2.84063073
84somatic diversification of immune receptors via somatic mutation (GO:0002566)2.84063073
85rRNA methylation (GO:0031167)2.82463958
86axoneme assembly (GO:0035082)2.82348514
87regulation of spindle organization (GO:0090224)2.82240838
88replication fork processing (GO:0031297)2.80954094
89telomere maintenance via recombination (GO:0000722)2.79981715
90viral transcription (GO:0019083)2.79192727
91cilium or flagellum-dependent cell motility (GO:0001539)2.78931089
92positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.78665633
93regulation of mitotic metaphase/anaphase transition (GO:0030071)2.78580666
94regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.78580666
95attachment of spindle microtubules to kinetochore (GO:0008608)2.78344361
96maintenance of gastrointestinal epithelium (GO:0030277)2.78047559
97oxidative phosphorylation (GO:0006119)2.77558394
98regulation of helicase activity (GO:0051095)2.76708505
99regulation of sister chromatid segregation (GO:0033045)2.75133363
100regulation of mitotic sister chromatid separation (GO:0010965)2.75133363
101regulation of mitotic sister chromatid segregation (GO:0033047)2.75133363
102mitotic sister chromatid segregation (GO:0000070)2.74352350
103intra-S DNA damage checkpoint (GO:0031573)2.74318846
104epithelial cilium movement (GO:0003351)2.73380402
105nucleobase biosynthetic process (GO:0046112)2.73035591
106meiotic chromosome segregation (GO:0045132)2.72808518
107establishment of viral latency (GO:0019043)2.72734499
108mitotic nuclear envelope disassembly (GO:0007077)2.72718169
109telomere maintenance via telomerase (GO:0007004)2.72343258
110cilium movement (GO:0003341)2.72066194
111translational termination (GO:0006415)2.72042335
112maturation of 5.8S rRNA (GO:0000460)2.71798401
113telomere maintenance via semi-conservative replication (GO:0032201)2.70025762
114dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.70020080
115RNA-dependent DNA replication (GO:0006278)2.69930804
116production of molecular mediator involved in inflammatory response (GO:0002532)2.69897973
117nuclear pore complex assembly (GO:0051292)2.68537742
118intestinal epithelial cell development (GO:0060576)2.67164835
119maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.65899764
120regulation of interferon-alpha production (GO:0032647)2.65844952
121negative regulation of mitotic sister chromatid separation (GO:2000816)2.65717418
122negative regulation of sister chromatid segregation (GO:0033046)2.65717418
123negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.65717418
124negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.65717418
125negative regulation of mitotic sister chromatid segregation (GO:0033048)2.65717418
126DNA-dependent DNA replication (GO:0006261)2.65000544
127fucose metabolic process (GO:0006004)2.64946152
128anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.64262526
129NIK/NF-kappaB signaling (GO:0038061)2.64109451
130tRNA aminoacylation for protein translation (GO:0006418)2.62740205
131CENP-A containing nucleosome assembly (GO:0034080)2.61917838
132regulation of centriole replication (GO:0046599)2.61815902
133negative regulation of chromosome segregation (GO:0051985)2.61396189
134diterpenoid biosynthetic process (GO:0016102)2.60891515
135DNA replication-dependent nucleosome organization (GO:0034723)2.59094658
136DNA replication-dependent nucleosome assembly (GO:0006335)2.59094658
137regulation of gamma-delta T cell differentiation (GO:0045586)2.59072170
138pseudouridine synthesis (GO:0001522)2.58802935
139amino acid activation (GO:0043038)2.58433677
140tRNA aminoacylation (GO:0043039)2.58433677
141B cell mediated immunity (GO:0019724)2.56985585
142response to interferon-beta (GO:0035456)2.55997019
143necroptotic process (GO:0070266)2.55208937
144protein localization to kinetochore (GO:0034501)2.52385903
145regulation of B cell differentiation (GO:0045577)2.50246882
146translational elongation (GO:0006414)2.49943996
147regulation of mitotic spindle organization (GO:0060236)2.48953895
148sister chromatid segregation (GO:0000819)2.48648508
149regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.48327972
150chromatin remodeling at centromere (GO:0031055)2.47538490
151sequestering of metal ion (GO:0051238)2.46476479
152megakaryocyte development (GO:0035855)2.44496552
153regulation of erythrocyte differentiation (GO:0045646)2.43536573
154regulation of gamma-delta T cell activation (GO:0046643)2.43336542
155positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.42914628
156regulation of necroptotic process (GO:0060544)2.41972279
157protein retention in ER lumen (GO:0006621)2.40706112
158positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.40532179
159protein localization to chromosome, centromeric region (GO:0071459)2.40466554
160chaperone mediated protein folding requiring cofactor (GO:0051085)2.40134717
161exocrine pancreas development (GO:0031017)2.40128082
162DNA replication-independent nucleosome organization (GO:0034724)2.38584636
163DNA replication-independent nucleosome assembly (GO:0006336)2.38584636
164purine-containing compound salvage (GO:0043101)2.37653261
165respiratory burst (GO:0045730)2.35600434
166regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.35557949
167actin nucleation (GO:0045010)2.35520132
168response to interferon-alpha (GO:0035455)2.34862809
169lipopolysaccharide biosynthetic process (GO:0009103)2.32276170
170regulation of sister chromatid cohesion (GO:0007063)2.31660729
171viral life cycle (GO:0019058)2.31641777
172O-glycan processing (GO:0016266)2.31308753
173establishment of chromosome localization (GO:0051303)2.31163950
174mitotic metaphase plate congression (GO:0007080)2.30150552
175negative regulation of erythrocyte differentiation (GO:0045647)2.29893323
176histone-serine phosphorylation (GO:0035404)2.29839749
177regulation of interleukin-12 biosynthetic process (GO:0045075)2.29378573
178kinetochore organization (GO:0051383)2.28393478
179nucleotide-sugar metabolic process (GO:0009225)2.28262539
180cytokinetic process (GO:0032506)2.27544738
181myeloid dendritic cell activation (GO:0001773)2.27511860
182metaphase plate congression (GO:0051310)2.25627159
183positive regulation of erythrocyte differentiation (GO:0045648)2.24923443
184positive regulation of interferon-beta production (GO:0032728)2.23560084
185lipopolysaccharide metabolic process (GO:0008653)2.23372613
186embryonic hemopoiesis (GO:0035162)2.23026731
187response to type I interferon (GO:0034340)2.22974723
188DNA unwinding involved in DNA replication (GO:0006268)2.21904803
189cellular protein complex disassembly (GO:0043624)2.20324088
190regulation of viral entry into host cell (GO:0046596)2.20306774

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.64726019
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.04252072
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.60973981
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.97884998
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.94117230
6GATA1_22025678_ChIP-Seq_K562_Human2.86613334
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.85442902
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.75429986
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.61227881
10* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.60917585
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.57394353
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57080687
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.53928483
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.52208272
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.48245942
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.46046430
17PADI4_21655091_ChIP-ChIP_MCF-7_Human2.33533039
18ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.25746583
19* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.23006682
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.19412395
21SCL_19346495_ChIP-Seq_HPC-7_Human2.16923796
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.15993162
23* HOXB4_20404135_ChIP-ChIP_EML_Mouse2.12818254
24SPI1_23547873_ChIP-Seq_NB4_Human2.08536402
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.01838271
26MYC_22102868_ChIP-Seq_BL_Human2.00117109
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.95872604
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.94654840
29* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91555323
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.90991176
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88756296
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.88348325
33VDR_21846776_ChIP-Seq_THP-1_Human1.84032282
34ERG_20887958_ChIP-Seq_HPC-7_Mouse1.81809048
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.79226643
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.79028470
37* MYB_26560356_Chip-Seq_TH2_Human1.78431243
38EWS_26573619_Chip-Seq_HEK293_Human1.77512815
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76979187
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.76199481
41FUS_26573619_Chip-Seq_HEK293_Human1.75824827
42VDR_23849224_ChIP-Seq_CD4+_Human1.71073006
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70244997
44SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.69531125
45ELK1_19687146_ChIP-ChIP_HELA_Human1.65059550
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.63825445
47SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.60197830
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.59559423
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58927931
50AR_21909140_ChIP-Seq_LNCAP_Human1.58863546
51HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.58188113
52IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55830107
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.54883782
54VDR_24763502_ChIP-Seq_THP-1_Human1.54396489
55VDR_22108803_ChIP-Seq_LS180_Human1.54009163
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.53045266
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52517386
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.52178400
59KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.51438896
60GATA1_22383799_ChIP-Seq_G1ME_Mouse1.50748538
61RUNX1_22412390_ChIP-Seq_EML_Mouse1.49205247
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48847916
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48273555
64CIITA_25753668_ChIP-Seq_RAJI_Human1.46942661
65STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.46811790
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.46655864
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.46349992
68FOXP3_21729870_ChIP-Seq_TREG_Human1.44929791
69BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44085509
70* MAF_26560356_Chip-Seq_TH1_Human1.42722889
71TFEB_21752829_ChIP-Seq_HELA_Human1.41411498
72MYB_26560356_Chip-Seq_TH1_Human1.40860754
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40791039
74MYC_18940864_ChIP-ChIP_HL60_Human1.38655242
75MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.36685431
76FOXM1_26456572_ChIP-Seq_MCF-7_Human1.35668402
77E2F1_21310950_ChIP-Seq_MCF-7_Human1.34385117
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33579753
79* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32653722
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31774574
81CREB1_15753290_ChIP-ChIP_HEK293T_Human1.31157662
82ZNF274_21170338_ChIP-Seq_K562_Hela1.30998282
83XRN2_22483619_ChIP-Seq_HELA_Human1.30903429
84BP1_19119308_ChIP-ChIP_Hs578T_Human1.30879732
85RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29603559
86FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29328996
87* UTX_26944678_Chip-Seq_JUKART_Human1.28872098
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28551084
89FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.27770465
90TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.26964860
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.26047041
92KDM5A_27292631_Chip-Seq_BREAST_Human1.25919187
93ETS1_20019798_ChIP-Seq_JURKAT_Human1.24201247
94* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.23136226
95FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.23033797
96NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22362341
97ELF5_23300383_ChIP-Seq_T47D_Human1.21620973
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20497592
99MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20023023
100CDX2_22108803_ChIP-Seq_LS180_Human1.19478807
101MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19458598
102LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19425534
103GABP_19822575_ChIP-Seq_HepG2_Human1.18699018
104PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18099390
105E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15181637
106SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.14891121
107GATA3_27048872_Chip-Seq_THYMUS_Human1.13440628
108MYC_18358816_ChIP-ChIP_MESCs_Mouse1.12251215
109NANOG_16153702_ChIP-ChIP_HESCs_Human1.11534805
110* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10839256
111MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10528230
112TTF2_22483619_ChIP-Seq_HELA_Human1.10250007
113* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10244044
114TCF7_22412390_ChIP-Seq_EML_Mouse1.08606431
115CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08031562
116E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07557573
117SPI1_23127762_ChIP-Seq_K562_Human1.05922549
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05074714
119ER_23166858_ChIP-Seq_MCF-7_Human1.05056634
120FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03848308
121HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03779173
122* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03752382
123DCP1A_22483619_ChIP-Seq_HELA_Human1.03091529
124EZH2_27294783_Chip-Seq_NPCs_Mouse1.02953396
125E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02839055
126ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02047607
127POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01366789
128PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01211116
129SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99909932
130NFE2_27457419_Chip-Seq_LIVER_Mouse0.99508326
131CHD1_26751641_Chip-Seq_LNCaP_Human0.99132295
132GATA6_25053715_ChIP-Seq_YYC3_Human0.98717863
133IGF1R_20145208_ChIP-Seq_DFB_Human0.98630621
134EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97884078
135* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97532004
136FOXA1_25329375_ChIP-Seq_VCAP_Human0.97473190
137FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97473190
138GATA3_24758297_ChIP-Seq_MCF-7_Human0.97343797
139GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97294261
140RUNX_20019798_ChIP-Seq_JUKART_Human0.97187317
141JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.96837444
142POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96663664
143SALL4_22934838_ChIP-ChIP_CD34+_Human0.96114407
144PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96085710
145MYC_19079543_ChIP-ChIP_MESCs_Mouse0.95362074
146GATA1_19941826_ChIP-Seq_K562_Human0.94455259
147* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93842682
148SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93200501
149PU_27001747_Chip-Seq_BMDM_Mouse0.91740202
150* PHF8_20622853_ChIP-Seq_HELA_Human0.91220882
151CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90891581
152NOTCH1_21737748_ChIP-Seq_TLL_Human0.90643335
153* RBPJ_21746931_ChIP-Seq_IB4_Human0.90404601
154AR_20517297_ChIP-Seq_VCAP_Human0.90205034
155GATA4_25053715_ChIP-Seq_YYC3_Human0.89925013
156ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89075650
157CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88813980
158FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88461191
159AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88042586
160* SOX17_20123909_ChIP-Seq_XEN_Mouse0.87542430
161CBP_20019798_ChIP-Seq_JUKART_Human0.84176479

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage3.79810763
2MP0003718_maternal_effect3.13857149
3MP0003941_abnormal_skin_development3.13217035
4MP0001835_abnormal_antigen_presentation2.92147326
5MP0003693_abnormal_embryo_hatching2.78509778
6MP0008875_abnormal_xenobiotic_pharmacok2.65810090
7MP0004147_increased_porphyrin_level2.57930071
8MP0000490_abnormal_crypts_of2.52457411
9MP0002166_altered_tumor_susceptibility2.45890168
10MP0001873_stomach_inflammation2.40785928
11MP0003866_abnormal_defecation2.38891489
12MP0010678_abnormal_skin_adnexa2.31029279
13MP0002396_abnormal_hematopoietic_system2.30296991
14MP0010155_abnormal_intestine_physiology2.24933589
15MP0004264_abnormal_extraembryonic_tissu2.18136127
16MP0000685_abnormal_immune_system2.16161463
17MP0008877_abnormal_DNA_methylation2.14889917
18MP0010352_gastrointestinal_tract_polyps2.13293335
19MP0009785_altered_susceptibility_to2.08945995
20MP0002877_abnormal_melanocyte_morpholog2.01289487
21MP0003300_gastrointestinal_ulcer1.97297615
22MP0005671_abnormal_response_to1.95235431
23MP0010234_abnormal_vibrissa_follicle1.92283207
24MP0002006_tumorigenesis1.91146807
25MP0003656_abnormal_erythrocyte_physiolo1.90927202
26MP0004808_abnormal_hematopoietic_stem1.88027797
27MP0002452_abnormal_antigen_presenting1.86417528
28MP0005085_abnormal_gallbladder_physiolo1.85918498
29MP0003195_calcinosis1.85208755
30MP0004957_abnormal_blastocyst_morpholog1.85037779
31MP0005025_abnormal_response_to1.84375054
32MP0005397_hematopoietic_system_phenotyp1.83258117
33MP0001545_abnormal_hematopoietic_system1.83258117
34MP0002796_impaired_skin_barrier1.82011448
35MP0009697_abnormal_copulation1.81482943
36MP0002420_abnormal_adaptive_immunity1.79723648
37MP0002398_abnormal_bone_marrow1.79488437
38MP0001800_abnormal_humoral_immune1.79228196
39MP0002148_abnormal_hypersensitivity_rea1.79030119
40MP0001819_abnormal_immune_cell1.78981308
41MP0005000_abnormal_immune_tolerance1.76882980
42MP0000465_gastrointestinal_hemorrhage1.75790329
43MP0003077_abnormal_cell_cycle1.75076404
44MP0003436_decreased_susceptibility_to1.74469528
45MP0002876_abnormal_thyroid_physiology1.73522084
46MP0005464_abnormal_platelet_physiology1.72903207
47MP0002009_preneoplasia1.72285266
48MP0005058_abnormal_lysosome_morphology1.71407867
49MP0006072_abnormal_retinal_apoptosis1.69317155
50MP0000383_abnormal_hair_follicle1.69136015
51MP0008932_abnormal_embryonic_tissue1.65586380
52MP0002419_abnormal_innate_immunity1.65382081
53MP0002723_abnormal_immune_serum1.64566282
54MP0005310_abnormal_salivary_gland1.63210870
55MP0003786_premature_aging1.61515870
56MP0004043_abnormal_pH_regulation1.60503629
57MP0003890_abnormal_embryonic-extraembry1.59153688
58MP0002163_abnormal_gland_morphology1.58645231
59MP0005395_other_phenotype1.56155763
60MP0003183_abnormal_peptide_metabolism1.52024156
61MP0005387_immune_system_phenotype1.50123171
62MP0001790_abnormal_immune_system1.50123171
63MP0000689_abnormal_spleen_morphology1.49587738
64MP0000716_abnormal_immune_system1.49438116
65MP0010094_abnormal_chromosome_stability1.48294058
66MP0003763_abnormal_thymus_physiology1.47752379
67MP0009333_abnormal_splenocyte_physiolog1.47043820
68MP0002722_abnormal_immune_system1.46590470
69MP0005365_abnormal_bile_salt1.46348000
70MP0001845_abnormal_inflammatory_respons1.45769684
71MP0002405_respiratory_system_inflammati1.45696779
72MP0008057_abnormal_DNA_replication1.44454084
73MP0002160_abnormal_reproductive_system1.44323929
74MP0002429_abnormal_blood_cell1.44105017
75MP0001663_abnormal_digestive_system1.42915944
76MP0003806_abnormal_nucleotide_metabolis1.34871612
77MP0001666_abnormal_nutrient_absorption1.30101470
78MP0003724_increased_susceptibility_to1.29833634
79MP0003111_abnormal_nucleus_morphology1.29115413
80MP0010307_abnormal_tumor_latency1.28953510
81MP0001188_hyperpigmentation1.26962992
82MP0001881_abnormal_mammary_gland1.26763211
83MP0000427_abnormal_hair_cycle1.25891590
84MP0002138_abnormal_hepatobiliary_system1.25434780
85MP0001661_extended_life_span1.25058260
86MP0002132_abnormal_respiratory_system1.24247218
87MP0004947_skin_inflammation1.23657876
88MP0006036_abnormal_mitochondrial_physio1.23444661
89MP0000477_abnormal_intestine_morphology1.21890317
90MP0005332_abnormal_amino_acid1.19918721
91MP0001672_abnormal_embryogenesis/_devel1.19725494
92MP0005380_embryogenesis_phenotype1.19725494
93MP0003303_peritoneal_inflammation1.18944760
94MP0001293_anophthalmia1.16406329
95MP0005220_abnormal_exocrine_pancreas1.16300554
96MP0005174_abnormal_tail_pigmentation1.15826030
97MP0003950_abnormal_plasma_membrane1.15136809
98MP0005083_abnormal_biliary_tract1.14770492
99MP0008007_abnormal_cellular_replicative1.12264355
100MP0005381_digestive/alimentary_phenotyp1.11789966
101MP0005389_reproductive_system_phenotype1.11760944
102MP0005501_abnormal_skin_physiology1.11403289
103MP0000569_abnormal_digit_pigmentation1.11151667
104MP0001764_abnormal_homeostasis1.11075158
105MP0005408_hypopigmentation1.09837178
106MP0001929_abnormal_gametogenesis1.07978287
107MP0002019_abnormal_tumor_incidence1.06099941
108MP0004215_abnormal_myocardial_fiber1.04148638
109MP0000703_abnormal_thymus_morphology1.03494974
110MP0009780_abnormal_chondrocyte_physiolo1.01824724
111MP0002084_abnormal_developmental_patter1.01012001
112MP0001727_abnormal_embryo_implantation0.99274817
113MP0003984_embryonic_growth_retardation0.98277136
114MP0000653_abnormal_sex_gland0.97242994
115MP0001346_abnormal_lacrimal_gland0.97115435
116MP0002088_abnormal_embryonic_growth/wei0.96583211
117MP0003937_abnormal_limbs/digits/tail_de0.96055059
118MP0000516_abnormal_urinary_system0.95681286
119MP0005367_renal/urinary_system_phenotyp0.95681286
120MP0001533_abnormal_skeleton_physiology0.95163145
121MP0000858_altered_metastatic_potential0.94695450
122MP0001145_abnormal_male_reproductive0.94266495
123MP0000350_abnormal_cell_proliferation0.93972335
124MP0001853_heart_inflammation0.93779332
125MP0003172_abnormal_lysosome_physiology0.93699921
126MP0002693_abnormal_pancreas_physiology0.93327337
127MP0005379_endocrine/exocrine_gland_phen0.93269029
128MP0003252_abnormal_bile_duct0.93043051
129MP0000313_abnormal_cell_death0.91619684
130MP0000627_abnormal_mammary_gland0.91348227
131MP0002085_abnormal_embryonic_tissue0.88950227
132MP0008469_abnormal_protein_level0.88899236
133MP0002210_abnormal_sex_determination0.88357304
134MP0006082_CNS_inflammation0.86412571
135MP0008058_abnormal_DNA_repair0.86391815
136MP0000647_abnormal_sebaceous_gland0.86156340
137MP0003943_abnormal_hepatobiliary_system0.85682068
138MP0000678_abnormal_parathyroid_gland0.84642812
139MP0001119_abnormal_female_reproductive0.82774657
140MP0009643_abnormal_urine_homeostasis0.81865572
141MP0003868_abnormal_feces_composition0.81515164
142MP0009703_decreased_birth_body0.80466187
143MP0003787_abnormal_imprinting0.80207655
144MP0005636_abnormal_mineral_homeostasis0.78755738
145MP0009278_abnormal_bone_marrow0.77607533
146MP0005076_abnormal_cell_differentiation0.77425318
147MP0001216_abnormal_epidermal_layer0.77268552
148MP0001765_abnormal_ion_homeostasis0.77177865
149MP0000377_abnormal_hair_follicle0.76140579
150MP0001730_embryonic_growth_arrest0.75596503
151MP0003936_abnormal_reproductive_system0.74379800
152MP0004197_abnormal_fetal_growth/weight/0.73650356
153MP0006035_abnormal_mitochondrial_morpho0.72055491
154MP0000613_abnormal_salivary_gland0.71056221
155MP0008789_abnormal_olfactory_epithelium0.70078461
156MP0001697_abnormal_embryo_size0.69605379
157MP0003186_abnormal_redox_activity0.68987872
158MP0000470_abnormal_stomach_morphology0.68184783
159MP0004782_abnormal_surfactant_physiolog0.67249365
160MP0002080_prenatal_lethality0.66605693
161MP0001944_abnormal_pancreas_morphology0.65416906
162MP0003448_altered_tumor_morphology0.65283685
163MP0003567_abnormal_fetal_cardiomyocyte0.64430648
164MP0002136_abnormal_kidney_physiology0.62691474
165MP0002086_abnormal_extraembryonic_tissu0.62432454
166MP0003566_abnormal_cell_adhesion0.61174938
167MP0001664_abnormal_digestion0.59928000

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.39056089
2Chronic bronchitis (HP:0004469)4.22974674
3Thrombocytosis (HP:0001894)4.17762366
4Recurrent abscess formation (HP:0002722)4.09406537
5Absent/shortened dynein arms (HP:0200106)3.80806901
6Dynein arm defect of respiratory motile cilia (HP:0012255)3.80806901
7Abnormal respiratory motile cilium physiology (HP:0012261)3.69554073
8Vacuolated lymphocytes (HP:0001922)3.59525440
9Recurrent bacterial skin infections (HP:0005406)3.58154214
10Rhinitis (HP:0012384)3.55924645
11Myositis (HP:0100614)3.44366412
12Aplastic anemia (HP:0001915)3.41242689
13Recurrent viral infections (HP:0004429)3.33755961
14Petechiae (HP:0000967)3.28765217
15Abnormal respiratory motile cilium morphology (HP:0005938)3.26627560
16Abnormal respiratory epithelium morphology (HP:0012253)3.26627560
17Abnormal ciliary motility (HP:0012262)3.24788003
18Chronic otitis media (HP:0000389)3.11495981
19Bronchiectasis (HP:0002110)3.00577142
20Autoimmune thrombocytopenia (HP:0001973)2.83764326
21Pancreatic cysts (HP:0001737)2.82130908
22Eczematoid dermatitis (HP:0000976)2.79951642
23Fatigue (HP:0012378)2.78020391
24Periodontitis (HP:0000704)2.77017673
25Chromsome breakage (HP:0040012)2.76178559
26IgM deficiency (HP:0002850)2.75586602
27Abnormality of macrophages (HP:0004311)2.75583450
28Reticulocytopenia (HP:0001896)2.74647704
29Recurrent fungal infections (HP:0002841)2.71471468
30Abnormality of the heme biosynthetic pathway (HP:0010472)2.70152560
31Ependymoma (HP:0002888)2.69753364
32True hermaphroditism (HP:0010459)2.67352277
33B lymphocytopenia (HP:0010976)2.66325559
34Abnormality of B cell number (HP:0010975)2.66325559
35Abnormality of aspartate family amino acid metabolism (HP:0010899)2.66023910
36Pancreatic fibrosis (HP:0100732)2.64499191
37Tubulointerstitial nephritis (HP:0001970)2.59299363
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.59162574
39Abnormality of T cell physiology (HP:0011840)2.58345470
40Orchitis (HP:0100796)2.56933640
41Increased cerebral lipofuscin (HP:0011813)2.56591550
42Pustule (HP:0200039)2.55964088
43Abnormality of chromosome stability (HP:0003220)2.54365071
44Abnormality of cells of the erythroid lineage (HP:0012130)2.53750080
45Recurrent bronchitis (HP:0002837)2.51518464
46Agnosia (HP:0010524)2.51474326
47Interstitial pulmonary disease (HP:0006530)2.50047153
48Abnormal number of erythroid precursors (HP:0012131)2.49473309
49Biliary tract neoplasm (HP:0100574)2.48461585
50Rhabdomyosarcoma (HP:0002859)2.48120786
51Cellulitis (HP:0100658)2.47256262
52Retrobulbar optic neuritis (HP:0100654)2.46950562
53Optic neuritis (HP:0100653)2.46950562
54Increased neuronal autofluorescent lipopigment (HP:0002074)2.46918345
55Neoplasm of the adrenal gland (HP:0100631)2.45071790
56Thyroiditis (HP:0100646)2.44760008
57Breast carcinoma (HP:0003002)2.42937132
58Thin bony cortex (HP:0002753)2.42112786
59Chronic diarrhea (HP:0002028)2.42033853
60Carpal bone hypoplasia (HP:0001498)2.40075406
61Abnormality of methionine metabolism (HP:0010901)2.39571589
62Generalized aminoaciduria (HP:0002909)2.38430984
63Dysostosis multiplex (HP:0000943)2.34673599
64Urinary glycosaminoglycan excretion (HP:0003541)2.34630203
65Mucopolysacchariduria (HP:0008155)2.34630203
66Gout (HP:0001997)2.34396324
67Aplasia/Hypoplasia of the uvula (HP:0010293)2.34078876
68Type I transferrin isoform profile (HP:0003642)2.31790386
69Pancreatic islet-cell hyperplasia (HP:0004510)2.26069645
70Hypoplasia of the uterus (HP:0000013)2.24206886
71Abnormal lung lobation (HP:0002101)2.22566807
72Decreased circulating renin level (HP:0003351)2.22424238
73Hyperinsulinemic hypoglycemia (HP:0000825)2.21643765
74Medial flaring of the eyebrow (HP:0010747)2.20677633
75Osteomyelitis (HP:0002754)2.20590079
76Supernumerary spleens (HP:0009799)2.20550800
77Reduced antithrombin III activity (HP:0001976)2.20109585
78Azoospermia (HP:0000027)2.18436187
79Abnormality of T cells (HP:0002843)2.18078143
80Meckel diverticulum (HP:0002245)2.18027872
81Elevated erythrocyte sedimentation rate (HP:0003565)2.17972609
82Palpitations (HP:0001962)2.17441568
83Methylmalonic acidemia (HP:0002912)2.16722632
84Abnormality of the preputium (HP:0100587)2.15840276
85Abnormality of the vitamin B12 metabolism (HP:0004341)2.15686808
86Abnormality of vitamin B metabolism (HP:0004340)2.15300672
87Amaurosis fugax (HP:0100576)2.14028079
88Glioma (HP:0009733)2.12056653
89Nasal polyposis (HP:0100582)2.11308450
90Ovarian neoplasm (HP:0100615)2.11087781
91Posterior subcapsular cataract (HP:0007787)2.11016915
92Megaloblastic anemia (HP:0001889)2.10955296
93Hyperglycinuria (HP:0003108)2.09679818
94Curly hair (HP:0002212)2.08386644
95Bronchitis (HP:0012387)2.07071067
96Nephroblastoma (Wilms tumor) (HP:0002667)2.07057073
97Abnormality of the ileum (HP:0001549)2.06986567
98Median cleft lip (HP:0000161)2.06972132
99Hypoproteinemia (HP:0003075)2.05376760
100Bile duct proliferation (HP:0001408)2.05350175
101Abnormal biliary tract physiology (HP:0012439)2.05350175
102Abnormality of polysaccharide metabolism (HP:0011012)2.05327011
103Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05327011
104Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05327011
105Molar tooth sign on MRI (HP:0002419)2.04987224
106Abnormality of midbrain morphology (HP:0002418)2.04987224
107Abnormality of the pancreatic islet cells (HP:0006476)2.04731679
108Abnormality of endocrine pancreas physiology (HP:0012093)2.04731679
109Neoplasm of the adrenal cortex (HP:0100641)2.04144608
110Micronodular cirrhosis (HP:0001413)2.03699623
111Hypoglycemic seizures (HP:0002173)2.03237225
112Myelodysplasia (HP:0002863)2.02052148
113Eosinophilia (HP:0001880)2.00440078
114Abnormal biliary tract morphology (HP:0012440)1.99934766
115Gonadotropin excess (HP:0000837)1.99313174
116Spondylolisthesis (HP:0003302)1.98401065
117Embryonal renal neoplasm (HP:0011794)1.97657991
118Small intestinal stenosis (HP:0012848)1.97584378
119Duodenal stenosis (HP:0100867)1.97584378
120Acute myeloid leukemia (HP:0004808)1.97073726
121Broad face (HP:0000283)1.96054084
122Aplasia/hypoplasia of the uterus (HP:0008684)1.94727071
123Abnormality of glycine metabolism (HP:0010895)1.94027061
124Abnormality of serine family amino acid metabolism (HP:0010894)1.94027061
125Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.94027049
126Abnormal protein N-linked glycosylation (HP:0012347)1.94027049
127Abnormal protein glycosylation (HP:0012346)1.94027049
128Abnormal glycosylation (HP:0012345)1.94027049
129Abnormality of the fingertips (HP:0001211)1.93404419
130Neoplasm of head and neck (HP:0012288)1.92603675
131Esophageal neoplasm (HP:0100751)1.92603675
132Abnormality of serum amino acid levels (HP:0003112)1.92583871
133Astrocytoma (HP:0009592)1.92559843
134Abnormality of the astrocytes (HP:0100707)1.92559843
135Abdominal distention (HP:0003270)1.92500714
136Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.91558473
137Ketoacidosis (HP:0001993)1.91464130
138Granulocytopenia (HP:0001913)1.91231349
139Abnormality of cells of the lymphoid lineage (HP:0012140)1.90845451
140Abnormality of the nasal mucosa (HP:0000433)1.90804346
141Poikiloderma (HP:0001029)1.90546089
142Thyroid carcinoma (HP:0002890)1.90443630
143Abnormal spermatogenesis (HP:0008669)1.90257492
144Abnormality of vitamin metabolism (HP:0100508)1.90104206
145Panhypogammaglobulinemia (HP:0003139)1.90013862
146Nephronophthisis (HP:0000090)1.89557998
147Combined immunodeficiency (HP:0005387)1.89499319
148Spontaneous hematomas (HP:0007420)1.89104082
149Right ventricular cardiomyopathy (HP:0011663)1.89100533
150Tubular atrophy (HP:0000092)1.88464376
151Aplasia/Hypoplasia of the tongue (HP:0010295)1.87918954
152Arterial thrombosis (HP:0004420)1.87671821
153Mediastinal lymphadenopathy (HP:0100721)1.87508447
154Recurrent skin infections (HP:0001581)1.87071424
155Aortic aneurysm (HP:0004942)1.86703002
156Neoplasm of the colon (HP:0100273)1.86084947
157Hypothermia (HP:0002045)1.85946363
158Lymphopenia (HP:0001888)1.85350232
159Leukocytosis (HP:0001974)1.84809315
160Neoplasm of the small intestine (HP:0100833)1.84668969
161Abnormality of eosinophils (HP:0001879)1.84178877
162Tetraparesis (HP:0002273)1.84107160
163Severe combined immunodeficiency (HP:0004430)1.83965503
164Abnormal delayed hypersensitivity skin test (HP:0002963)1.83418274
165Gastrointestinal stroma tumor (HP:0100723)1.83311330
166Meningitis (HP:0001287)1.82039046
167Abnormality of T cell number (HP:0011839)1.79808049
168Oculomotor apraxia (HP:0000657)1.79626678
169Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.78668776
170Abnormality of the duodenum (HP:0002246)1.78349403
171Congenital primary aphakia (HP:0007707)1.77658197
172Methylmalonic aciduria (HP:0012120)1.76508835
173Sloping forehead (HP:0000340)1.75630538
174Viral hepatitis (HP:0006562)1.75067164
175Hematochezia (HP:0002573)1.74363895
176Volvulus (HP:0002580)1.73948156
177Short middle phalanx of the 5th finger (HP:0004220)1.73915847
178Furrowed tongue (HP:0000221)1.73721892
179Lymphoma (HP:0002665)1.73595564
180Flattened epiphyses (HP:0003071)1.73594425
181Intrahepatic cholestasis (HP:0001406)1.73532567
182Subacute progressive viral hepatitis (HP:0006572)1.72886449
183Hypoglycemic coma (HP:0001325)1.72603979
184Prolonged bleeding time (HP:0003010)1.72323835
185Nephrogenic diabetes insipidus (HP:0009806)1.71993101
186Hyperactive renin-angiotensin system (HP:0000841)1.71900120
187Male pseudohermaphroditism (HP:0000037)1.71746130
188Occipital encephalocele (HP:0002085)1.70888726
189T lymphocytopenia (HP:0005403)1.69768982
190Hypoplasia of the thymus (HP:0000778)1.68940685

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.20932507
2BCR3.04185549
3FLT32.97679870
4BRSK22.93278596
5EEF2K2.79560738
6TRIM282.79057335
7SRPK12.77131990
8TAOK32.48305602
9KIT2.23381078
10MAP4K12.15872196
11BUB12.14571048
12SCYL22.11649588
13PASK2.10643305
14MKNK22.08191412
15TAF12.07726132
16STK102.00392261
17ERBB31.96888367
18PLK31.93190255
19TSSK61.89021570
20JAK31.85695332
21ERN11.84496278
22PKN21.84091241
23WEE11.84020507
24MST41.81804513
25NEK21.78468890
26MKNK11.77621702
27ZAK1.77591671
28VRK21.72152187
29TYK21.71304509
30TBK11.70980192
31LRRK21.67992371
32EPHA21.65572858
33BTK1.59830849
34EIF2AK31.57666913
35BRSK11.57530902
36PLK41.57227071
37CCNB11.56291168
38TEC1.54690075
39RPS6KB21.54251470
40STK38L1.53952191
41MAPKAPK31.53390500
42STK391.47798441
43TGFBR11.43909155
44EIF2AK11.32837716
45STK161.32036921
46PAK41.30231545
47ACVR1B1.28010455
48STK41.27666181
49OXSR11.27118926
50MATK1.21372470
51WNK31.18930387
52AKT31.18594721
53AURKB1.17045359
54FER1.15845139
55MAP3K81.15187667
56ZAP701.14995323
57TGFBR21.13133294
58IRAK41.13091754
59CSF1R1.12707579
60NME11.09959378
61MET1.09835536
62MAP3K121.09741345
63MYLK1.09094814
64CDC71.03543190
65EIF2AK21.01075303
66TESK11.00696128
67NEK90.99904837
68PIK3CA0.97510906
69TRPM70.97104087
70STK30.97039748
71MAP2K20.96161615
72PRKG20.95348018
73IKBKB0.94068636
74TNIK0.93804254
75CHUK0.93449110
76BMPR1B0.93000575
77PTK60.92338214
78IKBKE0.90706012
79NUAK10.86762834
80PIK3CG0.84476791
81NEK10.82601675
82GRK10.82575657
83SYK0.82498004
84NME20.81611430
85MAP3K20.80806008
86ATR0.80469878
87RPS6KA40.79899256
88NLK0.79488295
89ITK0.78120199
90BRAF0.77578304
91IRAK30.73764471
92LCK0.72782521
93STK240.72381229
94MAP3K130.71813017
95MAP3K100.71625574
96MST1R0.70963273
97LYN0.70953425
98MAPKAPK20.69886583
99MUSK0.69588460
100RIPK40.67484415
101CDK70.66141466
102INSRR0.66108718
103TRIB30.64537062
104CDK60.63736836
105JAK10.62745395
106ATM0.62214828
107MAP2K30.61970323
108PLK10.61916252
109MAP3K90.61774302
110GRK60.60957849
111CHEK10.59753811
112CDK30.57696310
113SIK30.57175543
114PIM10.54211490
115CSNK1G10.53530830
116PRKCI0.52945161
117MAP3K140.52894739
118JAK20.52501404
119ERBB40.51407153
120KDR0.51189455
121MARK30.51068202
122DYRK30.50916002
123PBK0.50402856
124TTK0.49554708
125CDK90.49210456
126PRKCE0.48625144
127CHEK20.47180283
128VRK10.46927721
129MAPK110.46675810
130DYRK1B0.45746501
131PLK20.45568063
132MAP3K10.45349124
133KSR10.45192791
134KSR20.45152987
135YES10.45028302
136FGFR30.45027736
137CSK0.43888866
138MELK0.43844554
139HIPK20.42918532
140LATS10.41218879
141CAMKK20.37465963
142RAF10.35670036
143BRD40.31420382
144CSNK1E0.29839451
145CSNK2A20.29438547
146AURKA0.27724432
147CSNK2A10.26887586
148NEK60.26310763
149CLK10.25501142
150FGFR10.25229636
151CSNK1A10.23776086
152FGFR20.23612091
153CDK10.19971541
154PRKAA20.16463382
155CDK20.16096693

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030602.60527575
2Caffeine metabolism_Homo sapiens_hsa002322.59885804
3Propanoate metabolism_Homo sapiens_hsa006402.52583336
4Non-homologous end-joining_Homo sapiens_hsa034502.24940948
5DNA replication_Homo sapiens_hsa030302.05509334
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03363783
7Leishmaniasis_Homo sapiens_hsa051401.99256869
8Antigen processing and presentation_Homo sapiens_hsa046121.89727122
9Sulfur metabolism_Homo sapiens_hsa009201.86263670
10Legionellosis_Homo sapiens_hsa051341.85235715
11Ribosome_Homo sapiens_hsa030101.81382220
12Selenocompound metabolism_Homo sapiens_hsa004501.80316151
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.76819422
14Cell cycle_Homo sapiens_hsa041101.71784895
15Other glycan degradation_Homo sapiens_hsa005111.71227989
16N-Glycan biosynthesis_Homo sapiens_hsa005101.70774679
17Mismatch repair_Homo sapiens_hsa034301.69057979
18Base excision repair_Homo sapiens_hsa034101.66461386
19Cysteine and methionine metabolism_Homo sapiens_hsa002701.64381710
20Fanconi anemia pathway_Homo sapiens_hsa034601.62443639
21Fatty acid elongation_Homo sapiens_hsa000621.62278941
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.59203590
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.58273778
24Pyruvate metabolism_Homo sapiens_hsa006201.57648895
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.53759176
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.53432527
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.50223674
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.49814503
29Herpes simplex infection_Homo sapiens_hsa051681.47968950
30Chemical carcinogenesis_Homo sapiens_hsa052041.47426293
31One carbon pool by folate_Homo sapiens_hsa006701.47234585
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.47124829
33Basal transcription factors_Homo sapiens_hsa030221.45683090
34Vitamin B6 metabolism_Homo sapiens_hsa007501.45681726
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.43885015
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.43470361
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.43245430
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39859507
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38761851
40Primary immunodeficiency_Homo sapiens_hsa053401.37694317
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36103911
42Influenza A_Homo sapiens_hsa051641.36008193
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.35921581
44Lysosome_Homo sapiens_hsa041421.35185473
45Measles_Homo sapiens_hsa051621.34414799
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.33328350
47Glutathione metabolism_Homo sapiens_hsa004801.33105422
48NF-kappa B signaling pathway_Homo sapiens_hsa040641.31727765
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31518022
50B cell receptor signaling pathway_Homo sapiens_hsa046621.29145659
51Thyroid cancer_Homo sapiens_hsa052161.29110236
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.27097001
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26676127
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.24793796
55Toxoplasmosis_Homo sapiens_hsa051451.24636933
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24398774
57Steroid biosynthesis_Homo sapiens_hsa001001.19220864
58Viral carcinogenesis_Homo sapiens_hsa052031.18022343
59Hematopoietic cell lineage_Homo sapiens_hsa046401.17192854
60Osteoclast differentiation_Homo sapiens_hsa043801.16337827
61Retinol metabolism_Homo sapiens_hsa008301.15912798
62Spliceosome_Homo sapiens_hsa030401.15192150
63Tryptophan metabolism_Homo sapiens_hsa003801.13934552
64Fatty acid degradation_Homo sapiens_hsa000711.13922593
65Apoptosis_Homo sapiens_hsa042101.13526775
66Leukocyte transendothelial migration_Homo sapiens_hsa046701.13412455
67Shigellosis_Homo sapiens_hsa051311.12601295
68p53 signaling pathway_Homo sapiens_hsa041151.11287917
69Renin-angiotensin system_Homo sapiens_hsa046141.10065736
70Hepatitis B_Homo sapiens_hsa051611.07832939
71RNA transport_Homo sapiens_hsa030131.06242140
72Pancreatic cancer_Homo sapiens_hsa052121.04479307
73Tuberculosis_Homo sapiens_hsa051521.04218263
74Systemic lupus erythematosus_Homo sapiens_hsa053221.03026196
75Butanoate metabolism_Homo sapiens_hsa006501.02529567
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01586832
77Cyanoamino acid metabolism_Homo sapiens_hsa004601.00957218
78Pertussis_Homo sapiens_hsa051331.00909223
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.00803750
80beta-Alanine metabolism_Homo sapiens_hsa004101.00269805
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99844157
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.99478760
83Fatty acid metabolism_Homo sapiens_hsa012120.98530508
84Small cell lung cancer_Homo sapiens_hsa052220.95555676
85Mineral absorption_Homo sapiens_hsa049780.95412994
86* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95383394
87Histidine metabolism_Homo sapiens_hsa003400.95367754
88Linoleic acid metabolism_Homo sapiens_hsa005910.95357764
89Homologous recombination_Homo sapiens_hsa034400.94402405
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92430308
91Epstein-Barr virus infection_Homo sapiens_hsa051690.92102262
92Purine metabolism_Homo sapiens_hsa002300.88507265
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88008098
94Chronic myeloid leukemia_Homo sapiens_hsa052200.86819464
95Platelet activation_Homo sapiens_hsa046110.86348597
96Vitamin digestion and absorption_Homo sapiens_hsa049770.85900263
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84686434
98RNA degradation_Homo sapiens_hsa030180.83419973
99Oocyte meiosis_Homo sapiens_hsa041140.83176682
100Pancreatic secretion_Homo sapiens_hsa049720.83117609
101Nucleotide excision repair_Homo sapiens_hsa034200.82919597
102TNF signaling pathway_Homo sapiens_hsa046680.82007681
103Acute myeloid leukemia_Homo sapiens_hsa052210.81657943
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81040512
105Proteasome_Homo sapiens_hsa030500.80924674
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80800545
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80570274
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80503563
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80216850
110Peroxisome_Homo sapiens_hsa041460.79769084
111Starch and sucrose metabolism_Homo sapiens_hsa005000.79507439
112Galactose metabolism_Homo sapiens_hsa000520.79410820
113Primary bile acid biosynthesis_Homo sapiens_hsa001200.78981147
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.77292890
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76776416
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76648872
117Carbon metabolism_Homo sapiens_hsa012000.76491103
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76440542
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75310850
120Malaria_Homo sapiens_hsa051440.72206331
121Metabolic pathways_Homo sapiens_hsa011000.71771016
122Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70633033
123Arginine and proline metabolism_Homo sapiens_hsa003300.70373721
124Hepatitis C_Homo sapiens_hsa051600.69182273
125Huntingtons disease_Homo sapiens_hsa050160.68821916
126Salmonella infection_Homo sapiens_hsa051320.68787432
127Ether lipid metabolism_Homo sapiens_hsa005650.65853123
128mRNA surveillance pathway_Homo sapiens_hsa030150.65377875
129Regulation of autophagy_Homo sapiens_hsa041400.64534257
130Colorectal cancer_Homo sapiens_hsa052100.64411325
131Pyrimidine metabolism_Homo sapiens_hsa002400.63947111
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61910913
133RNA polymerase_Homo sapiens_hsa030200.59029076
134Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59004948
135Vibrio cholerae infection_Homo sapiens_hsa051100.58649077
136Fat digestion and absorption_Homo sapiens_hsa049750.58054499
137Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56086854
138SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55948657
139Nitrogen metabolism_Homo sapiens_hsa009100.55790850
140Phagosome_Homo sapiens_hsa041450.54418362
141Chemokine signaling pathway_Homo sapiens_hsa040620.53333234
142Tyrosine metabolism_Homo sapiens_hsa003500.53145287
143Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52993579
144Biosynthesis of amino acids_Homo sapiens_hsa012300.52518149
145Arachidonic acid metabolism_Homo sapiens_hsa005900.51749881
146Notch signaling pathway_Homo sapiens_hsa043300.51525044
147Circadian rhythm_Homo sapiens_hsa047100.50384839
148Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50342883
149Type I diabetes mellitus_Homo sapiens_hsa049400.49676030
150Allograft rejection_Homo sapiens_hsa053300.49546308
151HIF-1 signaling pathway_Homo sapiens_hsa040660.49001636
152Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48962270
153HTLV-I infection_Homo sapiens_hsa051660.48894895
154Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47224607
155Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46844702
156Oxidative phosphorylation_Homo sapiens_hsa001900.46098791
157Prolactin signaling pathway_Homo sapiens_hsa049170.45942214
158Non-small cell lung cancer_Homo sapiens_hsa052230.45558128
159Fructose and mannose metabolism_Homo sapiens_hsa000510.44042343
160Phenylalanine metabolism_Homo sapiens_hsa003600.41961460
161Alcoholism_Homo sapiens_hsa050340.41503843
162Sphingolipid metabolism_Homo sapiens_hsa006000.37254515
163Folate biosynthesis_Homo sapiens_hsa007900.36414741
164Lysine degradation_Homo sapiens_hsa003100.34247220
165Parkinsons disease_Homo sapiens_hsa050120.30761296
166Tight junction_Homo sapiens_hsa045300.30229676
167Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.28281090

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