GOLGA8J

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.55942732
2positive regulation of gamma-delta T cell activation (GO:0046645)5.12657219
3definitive hemopoiesis (GO:0060216)4.93734866
4positive regulation of B cell differentiation (GO:0045579)4.80556791
5neutrophil activation involved in immune response (GO:0002283)4.51482249
6response to peptidoglycan (GO:0032494)4.50244675
7poly(A)+ mRNA export from nucleus (GO:0016973)4.43006395
8cellular extravasation (GO:0045123)4.40413086
9positive regulation of granulocyte differentiation (GO:0030854)4.20475688
10cell wall macromolecule metabolic process (GO:0044036)4.09972005
11regulation of B cell receptor signaling pathway (GO:0050855)4.07653439
12cell wall macromolecule catabolic process (GO:0016998)3.98892425
13negative regulation of granulocyte differentiation (GO:0030853)3.89569901
14regulation of B cell differentiation (GO:0045577)3.81505424
15regulation of gamma-delta T cell activation (GO:0046643)3.80100980
16B cell receptor signaling pathway (GO:0050853)3.79768310
17regulation of gamma-delta T cell differentiation (GO:0045586)3.72913052
18response to muramyl dipeptide (GO:0032495)3.68400700
19regulation of granulocyte differentiation (GO:0030852)3.41941577
20neutrophil mediated immunity (GO:0002446)3.35607021
21negative regulation of cell killing (GO:0031342)3.32839488
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.32839488
23microglial cell activation (GO:0001774)3.30188676
24regulation of mast cell degranulation (GO:0043304)3.29716966
25positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.29192834
26interkinetic nuclear migration (GO:0022027)3.24777141
27regulation of mast cell activation involved in immune response (GO:0033006)3.23865327
28piRNA metabolic process (GO:0034587)3.21606675
29negative regulation of T cell mediated immunity (GO:0002710)3.17689026
30regulation of myeloid leukocyte mediated immunity (GO:0002886)3.17620116
31negative regulation of interleukin-8 production (GO:0032717)3.16617052
32positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.08736465
33neutrophil activation (GO:0042119)3.08653605
34regulation of female gonad development (GO:2000194)3.08325823
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.08271290
36regulation of leukocyte degranulation (GO:0043300)3.07341833
37immunoglobulin mediated immune response (GO:0016064)3.05437648
38regulation of mast cell activation (GO:0033003)3.02356199
39cellular response to exogenous dsRNA (GO:0071360)3.01807611
40positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.00051266
41mature B cell differentiation involved in immune response (GO:0002313)2.99878563
42negative regulation of lymphocyte mediated immunity (GO:0002707)2.99369032
43regulation of hypersensitivity (GO:0002883)2.90509204
44negative regulation of interleukin-12 production (GO:0032695)2.89291581
45modulation of growth of symbiont involved in interaction with host (GO:0044144)2.88879407
46regulation of growth of symbiont in host (GO:0044126)2.88879407
47negative regulation of growth of symbiont in host (GO:0044130)2.88879407
48negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.88879407
49mannose metabolic process (GO:0006013)2.87160398
50myeloid cell activation involved in immune response (GO:0002275)2.86835940
51leukocyte degranulation (GO:0043299)2.86173715
52positive thymic T cell selection (GO:0045059)2.84137167
53antigen processing and presentation of endogenous antigen (GO:0019883)2.83601273
54regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.82788509
55megakaryocyte development (GO:0035855)2.82515937
56positive regulation of mast cell degranulation (GO:0043306)2.81159202
57positive regulation of mast cell activation involved in immune response (GO:0033008)2.81159202
58positive regulation of T-helper cell differentiation (GO:0045624)2.80978351
59response to protozoan (GO:0001562)2.78204259
60regulation of erythrocyte differentiation (GO:0045646)2.78168634
61positive regulation of interleukin-17 production (GO:0032740)2.75960425
62positive regulation of mast cell activation (GO:0033005)2.73245552
63granulocyte activation (GO:0036230)2.71814602
64detection of other organism (GO:0098543)2.70336138
65mast cell activation (GO:0045576)2.69605020
66regulation of interleukin-17 production (GO:0032660)2.68808589
67negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.67644115
68positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.65887947
69modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.65733747
70positive regulation by organism of defense response of other organism involved in symbiotic interact2.65733747
71modulation by symbiont of host immune response (GO:0052553)2.65733747
72positive regulation by symbiont of host defense response (GO:0052509)2.65733747
73modulation by symbiont of host defense response (GO:0052031)2.65733747
74modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.65733747
75germinal center formation (GO:0002467)2.65480371
76histone H3-K9 modification (GO:0061647)2.64508727
77activated T cell proliferation (GO:0050798)2.64420840
78regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.64101031
79regulation of regulated secretory pathway (GO:1903305)2.63770285
80negative regulation of interleukin-6 production (GO:0032715)2.63279582
81defense response to protozoan (GO:0042832)2.63098326
82myeloid leukocyte mediated immunity (GO:0002444)2.62873497
83necroptotic process (GO:0070266)2.62460339
84detection of bacterium (GO:0016045)2.61617667
85negative thymic T cell selection (GO:0045060)2.60712332
86negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.59164556
87negative regulation of T-helper cell differentiation (GO:0045623)2.59164556
88histone H3-K9 methylation (GO:0051567)2.58608482
89macrophage activation involved in immune response (GO:0002281)2.58040464
90regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.56905490
91mature B cell differentiation (GO:0002335)2.55478513
92antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.55278047
93regulation of platelet aggregation (GO:0090330)2.54612990
94macrophage activation (GO:0042116)2.53151537
95regulation of B cell apoptotic process (GO:0002902)2.51916088
96negative regulation of interleukin-17 production (GO:0032700)2.51568302
97negative regulation of leukocyte mediated immunity (GO:0002704)2.50872268
98B cell homeostasis (GO:0001782)2.50160856
99regulation of germinal center formation (GO:0002634)2.49467294
100positive regulation of natural killer cell activation (GO:0032816)2.49240627

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.37351941
2SCL_19346495_ChIP-Seq_HPC-7_Human3.87572301
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.35413032
4VDR_24763502_ChIP-Seq_THP-1_Human3.26183290
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.20955480
6VDR_21846776_ChIP-Seq_THP-1_Human3.16413490
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.05081223
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.00428668
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.79493086
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.74573832
11MYB_26560356_Chip-Seq_TH2_Human2.71231127
12RUNX_20019798_ChIP-Seq_JUKART_Human2.65037565
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.53228704
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.48415546
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.42217885
16GATA1_22025678_ChIP-Seq_K562_Human2.39232634
17VDR_24787735_ChIP-Seq_THP-1_Human2.37434677
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.34647788
19SPI1_23547873_ChIP-Seq_NB4_Human2.34188394
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.22785593
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.15719528
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.09864801
23MYB_26560356_Chip-Seq_TH1_Human2.08833280
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.07616095
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03996932
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.98570262
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.89671665
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.88273533
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.87837253
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.87008369
31SPI1_23127762_ChIP-Seq_K562_Human1.83368273
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.78564302
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.75573201
34GATA3_27048872_Chip-Seq_THYMUS_Human1.63669125
35GATA3_26560356_Chip-Seq_TH2_Human1.63643878
36GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.63216524
37VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.59123054
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.53403841
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52576387
40SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51672137
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50017155
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.49594858
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46790533
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.45969720
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40924630
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39178724
47IGF1R_20145208_ChIP-Seq_DFB_Human1.37417207
48UTX_26944678_Chip-Seq_JUKART_Human1.37229956
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32623233
50MAF_26560356_Chip-Seq_TH1_Human1.28833762
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27959139
52STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25624525
53PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25414639
54EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22016180
55MYC_22102868_ChIP-Seq_BL_Human1.21964612
56ER_23166858_ChIP-Seq_MCF-7_Human1.20561706
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19904685
58VDR_22108803_ChIP-Seq_LS180_Human1.19684274
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19302806
60ZNF274_21170338_ChIP-Seq_K562_Hela1.17991254
61RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.17696242
62GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15942471
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13032811
64SMRT_27268052_Chip-Seq_Bcells_Human1.12435002
65FUS_26573619_Chip-Seq_HEK293_Human1.08701525
66TCF7_22412390_ChIP-Seq_EML_Mouse1.08618939
67GATA1_19941827_ChIP-Seq_MEL_Mouse1.08470911
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06740253
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06130901
70GATA2_19941826_ChIP-Seq_K562_Human1.05737133
71CIITA_25753668_ChIP-Seq_RAJI_Human1.04578759
72CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01269923
73TAF15_26573619_Chip-Seq_HEK293_Human1.00259533
74FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98970050
75KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97933815
76STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96537126
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94518620
78GATA1_19941827_ChIP-Seq_MEL86_Mouse0.94470467
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.94144088
80CBP_20019798_ChIP-Seq_JUKART_Human0.93871589
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93871589
82MAF_26560356_Chip-Seq_TH2_Human0.93632184
83GATA3_26560356_Chip-Seq_TH1_Human0.93041952
84ETS1_22383799_ChIP-Seq_G1ME_Mouse0.92704925
85GATA1_19941826_ChIP-Seq_K562_Human0.92644087
86PRDM14_20953172_ChIP-Seq_ESCs_Human0.91009847
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90846032
88PU_27001747_Chip-Seq_BMDM_Mouse0.90211052
89TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.86458045
90CEBPB_22108803_ChIP-Seq_LS180_Human0.85999136
91TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85519838
92RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83831396
93EWS_26573619_Chip-Seq_HEK293_Human0.83674957
94KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.83586680
95TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81550812
96GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.79507069
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79317191
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.79186909
99FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78702261
100FLI1_27457419_Chip-Seq_LIVER_Mouse0.78697462

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.45582045
2MP0003172_abnormal_lysosome_physiology3.18219964
3MP0002396_abnormal_hematopoietic_system2.86709754
4MP0005397_hematopoietic_system_phenotyp2.76558407
5MP0001545_abnormal_hematopoietic_system2.76558407
6MP0005464_abnormal_platelet_physiology2.65181824
7MP0003303_peritoneal_inflammation2.53091478
8MP0009278_abnormal_bone_marrow2.50106298
9MP0003436_decreased_susceptibility_to2.39220728
10MP0002009_preneoplasia2.38965096
11MP0003724_increased_susceptibility_to2.35026098
12MP0002419_abnormal_innate_immunity2.32154614
13MP0004808_abnormal_hematopoietic_stem2.25476954
14MP0001800_abnormal_humoral_immune2.23561006
15MP0003763_abnormal_thymus_physiology2.16260558
16MP0002723_abnormal_immune_serum1.98294644
17MP0005058_abnormal_lysosome_morphology1.96900314
18MP0005025_abnormal_response_to1.95621476
19MP0002420_abnormal_adaptive_immunity1.94372652
20MP0002148_abnormal_hypersensitivity_rea1.94354944
21MP0001819_abnormal_immune_cell1.91336179
22MP0005000_abnormal_immune_tolerance1.88556421
23MP0002398_abnormal_bone_marrow1.82666994
24MP0002452_abnormal_antigen_presenting1.82651304
25MP0006082_CNS_inflammation1.80011239
26MP0002166_altered_tumor_susceptibility1.79012203
27MP0009785_altered_susceptibility_to1.77821584
28MP0000465_gastrointestinal_hemorrhage1.68638948
29MP0003828_pulmonary_edema1.68353479
30MP0003183_abnormal_peptide_metabolism1.67994154
31MP0000689_abnormal_spleen_morphology1.67528097
32MP0000716_abnormal_immune_system1.65717581
33MP0003787_abnormal_imprinting1.64698192
34MP0008057_abnormal_DNA_replication1.58569637
35MP0000685_abnormal_immune_system1.58481227
36MP0002722_abnormal_immune_system1.55408995
37MP0005671_abnormal_response_to1.50474103
38MP0001790_abnormal_immune_system1.48406154
39MP0005387_immune_system_phenotype1.48406154
40MP0005075_abnormal_melanosome_morpholog1.47917354
41MP0002405_respiratory_system_inflammati1.45615028
42MP0005666_abnormal_adipose_tissue1.42924687
43MP0005174_abnormal_tail_pigmentation1.40236867
44MP0000569_abnormal_digit_pigmentation1.39023321
45MP0002138_abnormal_hepatobiliary_system1.36953055
46MP0002429_abnormal_blood_cell1.35478875
47MP0004130_abnormal_muscle_cell1.33789136
48MP0000681_abnormal_thyroid_gland1.33262831
49MP0000703_abnormal_thymus_morphology1.32966237
50MP0003656_abnormal_erythrocyte_physiolo1.28410101
51MP0002876_abnormal_thyroid_physiology1.22711862
52MP0001845_abnormal_inflammatory_respons1.21657498
53MP0003300_gastrointestinal_ulcer1.20428681
54MP0010155_abnormal_intestine_physiology1.19782358
55MP0000015_abnormal_ear_pigmentation1.19077813
56MP0002837_dystrophic_cardiac_calcinosis1.19048548
57MP0005410_abnormal_fertilization1.15226762
58MP0008469_abnormal_protein_level1.15006045
59MP0008877_abnormal_DNA_methylation1.14597257
60MP0004185_abnormal_adipocyte_glucose1.14533455
61MP0002971_abnormal_brown_adipose1.14049497
62MP0002132_abnormal_respiratory_system1.13580447
63MP0004484_altered_response_of1.11405246
64MP0002006_tumorigenesis1.11170016
65MP0009764_decreased_sensitivity_to1.10552121
66MP0001851_eye_inflammation1.10193039
67MP0001533_abnormal_skeleton_physiology1.07415094
68MP0003195_calcinosis1.06327961
69MP0005535_abnormal_body_temperature1.06116215
70MP0001853_heart_inflammation1.04363702
71MP0003646_muscle_fatigue1.04103863
72MP0009333_abnormal_splenocyte_physiolog1.00573479
73MP0001986_abnormal_taste_sensitivity0.98021125
74MP0001764_abnormal_homeostasis0.94165882
75MP0009115_abnormal_fat_cell0.91243996
76MP0009379_abnormal_foot_pigmentation0.87683448
77MP0001501_abnormal_sleep_pattern0.87619244
78MP0005334_abnormal_fat_pad0.86667026
79MP0001765_abnormal_ion_homeostasis0.85878480
80MP0002139_abnormal_hepatobiliary_system0.83848833
81MP0005310_abnormal_salivary_gland0.82533444
82MP0003252_abnormal_bile_duct0.78642803
83MP0003045_fibrosis0.78595962
84MP0002998_abnormal_bone_remodeling0.76697630
85MP0004947_skin_inflammation0.76383456
86MP0001873_stomach_inflammation0.74874268
87MP0002693_abnormal_pancreas_physiology0.73355676
88MP0005670_abnormal_white_adipose0.72984967
89MP0001929_abnormal_gametogenesis0.71440342
90MP0002928_abnormal_bile_duct0.71250244
91MP0005375_adipose_tissue_phenotype0.71006780
92MP0003075_altered_response_to0.70941911
93MP0003191_abnormal_cellular_cholesterol0.69236701
94MP0003959_abnormal_lean_body0.67307770
95MP0003690_abnormal_glial_cell0.66124705
96MP0003806_abnormal_nucleotide_metabolis0.65963514
97MP0003866_abnormal_defecation0.65657761
98MP0003786_premature_aging0.65171226
99MP0003698_abnormal_male_reproductive0.64870054
100MP0006036_abnormal_mitochondrial_physio0.63940409

Predicted human phenotypes

RankGene SetZ-score
1Acute lymphatic leukemia (HP:0006721)4.92620969
2Elevated erythrocyte sedimentation rate (HP:0003565)4.83629539
3Myositis (HP:0100614)3.96460485
4Stomatitis (HP:0010280)3.95571226
5Recurrent abscess formation (HP:0002722)3.84019433
6Acute myeloid leukemia (HP:0004808)3.77362193
7Prolonged bleeding time (HP:0003010)3.61473229
8Recurrent cutaneous fungal infections (HP:0011370)3.59692378
9Chronic mucocutaneous candidiasis (HP:0002728)3.59692378
10Abnormal delayed hypersensitivity skin test (HP:0002963)3.54731679
11Recurrent bacterial skin infections (HP:0005406)3.49967228
12Abnormality of B cell number (HP:0010975)3.45118078
13Recurrent fungal infections (HP:0002841)3.37767363
14B lymphocytopenia (HP:0010976)3.27013025
15Thrombocytosis (HP:0001894)3.22137563
16Panhypogammaglobulinemia (HP:0003139)3.14077485
17Increased neuronal autofluorescent lipopigment (HP:0002074)3.06999872
18Abnormality of macular pigmentation (HP:0008002)3.03282752
19Recurrent skin infections (HP:0001581)2.94132179
20Thoracic kyphosis (HP:0002942)2.92299228
21Spontaneous hematomas (HP:0007420)2.83214601
22Epistaxis (HP:0000421)2.82998682
23Abnormality of T cell physiology (HP:0011840)2.79151781
24Abnormality of the prostate (HP:0008775)2.78580193
25Encephalitis (HP:0002383)2.78027941
26Gastrointestinal infarctions (HP:0005244)2.75689154
27Meningitis (HP:0001287)2.71606825
28Inflammation of the large intestine (HP:0002037)2.71574492
29Chest pain (HP:0100749)2.70825440
30Dysostosis multiplex (HP:0000943)2.69573865
31Increased cerebral lipofuscin (HP:0011813)2.68946427
32Metaphyseal dysplasia (HP:0100255)2.68178707
33Recurrent viral infections (HP:0004429)2.63838357
34Obstructive lung disease (HP:0006536)2.63125387
35Chronic obstructive pulmonary disease (HP:0006510)2.63125387
36Orchitis (HP:0100796)2.63101901
37Attenuation of retinal blood vessels (HP:0007843)2.61591336
38Gingival bleeding (HP:0000225)2.61193099
39Gastrointestinal inflammation (HP:0004386)2.60296799
40Abnormality of the lumbar spine (HP:0100712)2.58069691
41Abnormal rod and cone electroretinograms (HP:0008323)2.56724573
42Agammaglobulinemia (HP:0004432)2.53803599
43Episodic fever (HP:0001954)2.52772303
44Granulocytopenia (HP:0001913)2.52333368
45Optic neuritis (HP:0100653)2.52318782
46Retrobulbar optic neuritis (HP:0100654)2.52318782
47Papilledema (HP:0001085)2.50081758
48Abnormality of T cells (HP:0002843)2.45022640
49Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.44611797
50Absent rod-and cone-mediated responses on ERG (HP:0007688)2.42277082
51Vasculitis (HP:0002633)2.36840638
52Mediastinal lymphadenopathy (HP:0100721)2.35679050
53Hemoptysis (HP:0002105)2.34767715
54Pulmonary embolism (HP:0002204)2.31056536
55Petechiae (HP:0000967)2.29949116
56Arterial thrombosis (HP:0004420)2.29233572
57Abnormality of macrophages (HP:0004311)2.27637941
58Amyloidosis (HP:0011034)2.23526214
59Abnormality of liposaccharide metabolism (HP:0010968)2.22103489
60Abnormality of glycosphingolipid metabolism (HP:0004343)2.22103489
61Abnormality of glycolipid metabolism (HP:0010969)2.22103489
62Leukocytosis (HP:0001974)2.21903898
63Severe visual impairment (HP:0001141)2.20394508
64Abnormality of the vasculature of the conjunctiva (HP:0008054)2.18546654
65Spondylolisthesis (HP:0003302)2.18064854
66Autoimmune hemolytic anemia (HP:0001890)2.17300088
67Thickened calvaria (HP:0002684)2.17164404
68Pustule (HP:0200039)2.15381160
69Keratoconjunctivitis sicca (HP:0001097)2.11788680
70Neurodegeneration (HP:0002180)2.08857944
71Keratoconjunctivitis (HP:0001096)2.08680404
72T lymphocytopenia (HP:0005403)2.06945635
73Central scotoma (HP:0000603)2.06453559
74Constricted visual fields (HP:0001133)2.04757907
75Colitis (HP:0002583)2.03974944
76Abnormality of the thoracic spine (HP:0100711)2.03322209
77Abnormality of T cell number (HP:0011839)1.99114693
78Decreased central vision (HP:0007663)1.98267105
79Eczematoid dermatitis (HP:0000976)1.97433118
80Increased IgE level (HP:0003212)1.96807124
81Chronic diarrhea (HP:0002028)1.95629731
82Recurrent gram-negative bacterial infections (HP:0005420)1.94934798
83Pulmonary infiltrates (HP:0002113)1.94287490
84Vacuolated lymphocytes (HP:0001922)1.93936985
85Abolished electroretinogram (ERG) (HP:0000550)1.93910924
86Severe combined immunodeficiency (HP:0004430)1.92555694
87Cheilitis (HP:0100825)1.90713583
88Abnormality of mucopolysaccharide metabolism (HP:0011020)1.89763869
89Abnormality of polysaccharide metabolism (HP:0011012)1.89763869
90Abnormality of glycosaminoglycan metabolism (HP:0004371)1.89763869
91Fatigue (HP:0012378)1.86722733
92Dyschromatopsia (HP:0007641)1.82560404
93Mucopolysacchariduria (HP:0008155)1.82487116
94Urinary glycosaminoglycan excretion (HP:0003541)1.82487116
95Abnormality of the columella (HP:0009929)1.78362375
96Urticaria (HP:0001025)1.78080005
97Autoimmune thrombocytopenia (HP:0001973)1.77713341
98Microcytic anemia (HP:0001935)1.77580783
99Acute hepatic failure (HP:0006554)1.77239450
100Hypochromic microcytic anemia (HP:0004840)1.77140179

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KIT3.41129389
2RIPK43.40484355
3MAP3K133.23570452
4TAOK33.04187959
5FRK2.96735521
6TEC2.69470353
7FES2.56991676
8MAP3K142.37724475
9MAP4K12.32560283
10FLT32.24252304
11MAP2K32.24146460
12TXK2.18915005
13CSF1R2.04137756
14SYK1.99839750
15CDK61.90731867
16BTK1.89135213
17ZAP701.76136184
18MAP3K61.71583955
19ITK1.70496070
20TNK21.69680344
21TBK11.56264005
22TRPM71.56012540
23BLK1.49744596
24PIK3CG1.42717023
25GRK61.40519144
26CDK191.36261846
27ERN11.34710603
28DAPK21.33299676
29HCK1.30199720
30IKBKB1.28232625
31JAK31.27894940
32TYK21.27484357
33MATK1.22707479
34HIPK21.22276548
35IRAK41.21934909
36BMPR21.21690929
37PRPF4B1.19552992
38LYN1.18586879
39BRD41.14710139
40MAP3K71.14264241
41NUAK11.12031163
42MAP2K61.11496829
43CDK31.03480382
44PDK11.01195645
45LCK1.01038295
46MARK30.98587564
47MAP4K20.95708222
48MAPK70.95307324
49IKBKE0.94375765
50ACVR1B0.90214995
51PRKCQ0.89936632
52RPS6KA40.85764373
53YES10.85326109
54MAPK120.84326201
55ADRBK20.82480505
56RPS6KA60.82047919
57JAK20.80316807
58CSK0.80053884
59RPS6KC10.79715951
60RPS6KL10.79715951
61MAP2K20.79293568
62PDPK10.77252560
63RPS6KB20.72405287
64CDK40.64772600
65JAK10.64678325
66PRKAA20.64096046
67IRAK10.61023272
68PTK2B0.60416078
69STK110.59570478
70INSRR0.58698742
71CAMK1G0.57848241
72PASK0.57247099
73PRKG20.56636633
74MAPK110.49614178
75PIM10.47384405
76TAF10.47249489
77NEK90.46571296
78MAP2K40.46047697
79EEF2K0.45203108
80MAPK30.44624598
81CDK120.44294760
82PLK40.42993938
83WNK10.41588687
84ABL10.40560020
85GRK70.38629469
86MAPK40.38356701
87MAP3K50.37752331
88SGK10.35948341
89RET0.33839228
90MKNK10.33461729
91MAP3K10.32155055
92CAMK10.32136665
93MAPK130.31472758
94ADRBK10.30435036
95RPS6KB10.30246619
96IGF1R0.28914949
97MAPK100.27151449
98PINK10.27066348
99CAMKK20.26677345
100MAPK10.23256965

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.95888605
2Asthma_Homo sapiens_hsa053102.74713379
3Leishmaniasis_Homo sapiens_hsa051402.57780325
4Allograft rejection_Homo sapiens_hsa053302.51112880
5Graft-versus-host disease_Homo sapiens_hsa053322.45964234
6Type I diabetes mellitus_Homo sapiens_hsa049402.26560345
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.22945326
8Autoimmune thyroid disease_Homo sapiens_hsa053202.15113321
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.12337990
10B cell receptor signaling pathway_Homo sapiens_hsa046622.10383533
11Staphylococcus aureus infection_Homo sapiens_hsa051502.01109094
12Osteoclast differentiation_Homo sapiens_hsa043801.96342818
13Acute myeloid leukemia_Homo sapiens_hsa052211.89767602
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.73561532
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.72915048
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.67399184
17Dorso-ventral axis formation_Homo sapiens_hsa043201.66164963
18Platelet activation_Homo sapiens_hsa046111.63366036
19Tuberculosis_Homo sapiens_hsa051521.58628243
20Hematopoietic cell lineage_Homo sapiens_hsa046401.54357513
21T cell receptor signaling pathway_Homo sapiens_hsa046601.47481518
22Transcriptional misregulation in cancer_Homo sapiens_hsa052021.45942442
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45594233
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.45189521
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.41955546
26Primary immunodeficiency_Homo sapiens_hsa053401.32205318
27Influenza A_Homo sapiens_hsa051641.31173001
28Herpes simplex infection_Homo sapiens_hsa051681.28608471
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.27239641
30Glycerophospholipid metabolism_Homo sapiens_hsa005641.24581213
31Toxoplasmosis_Homo sapiens_hsa051451.20646088
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.20166630
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.20139067
34Antigen processing and presentation_Homo sapiens_hsa046121.19094669
35Rheumatoid arthritis_Homo sapiens_hsa053231.16425194
36Measles_Homo sapiens_hsa051621.12809796
37African trypanosomiasis_Homo sapiens_hsa051431.12502278
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09363976
39Lysosome_Homo sapiens_hsa041421.00739237
40Legionellosis_Homo sapiens_hsa051340.98862820
41SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98010534
42Malaria_Homo sapiens_hsa051440.96553329
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93406630
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92749712
45TNF signaling pathway_Homo sapiens_hsa046680.91378019
46Renin secretion_Homo sapiens_hsa049240.89860973
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89840136
48Adipocytokine signaling pathway_Homo sapiens_hsa049200.88498542
49ABC transporters_Homo sapiens_hsa020100.87486522
50Chemokine signaling pathway_Homo sapiens_hsa040620.86420285
51Ether lipid metabolism_Homo sapiens_hsa005650.86224862
52Regulation of autophagy_Homo sapiens_hsa041400.85786173
53Insulin resistance_Homo sapiens_hsa049310.85476076
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84172133
55Salivary secretion_Homo sapiens_hsa049700.83800469
56Viral myocarditis_Homo sapiens_hsa054160.79133920
57Type II diabetes mellitus_Homo sapiens_hsa049300.76996679
58Non-small cell lung cancer_Homo sapiens_hsa052230.76690527
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75465967
60mTOR signaling pathway_Homo sapiens_hsa041500.74853992
61Hepatitis B_Homo sapiens_hsa051610.74192123
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73766245
63Prolactin signaling pathway_Homo sapiens_hsa049170.72795437
64Olfactory transduction_Homo sapiens_hsa047400.72179901
65Chronic myeloid leukemia_Homo sapiens_hsa052200.72019818
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70781098
67Pertussis_Homo sapiens_hsa051330.69122462
68Choline metabolism in cancer_Homo sapiens_hsa052310.68710027
69Pancreatic secretion_Homo sapiens_hsa049720.66436454
70Linoleic acid metabolism_Homo sapiens_hsa005910.64964445
71Arachidonic acid metabolism_Homo sapiens_hsa005900.63894006
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.62239537
73Renin-angiotensin system_Homo sapiens_hsa046140.60222435
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.59089345
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.57976388
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57528682
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56552414
78Long-term depression_Homo sapiens_hsa047300.53688643
79Inositol phosphate metabolism_Homo sapiens_hsa005620.53682238
80Pancreatic cancer_Homo sapiens_hsa052120.52991517
81VEGF signaling pathway_Homo sapiens_hsa043700.52835491
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52079991
83Ovarian steroidogenesis_Homo sapiens_hsa049130.52032648
84Glycerolipid metabolism_Homo sapiens_hsa005610.51721557
85Oxytocin signaling pathway_Homo sapiens_hsa049210.50954283
86MAPK signaling pathway_Homo sapiens_hsa040100.49219196
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.48546992
88Hepatitis C_Homo sapiens_hsa051600.48395679
89GnRH signaling pathway_Homo sapiens_hsa049120.46771281
90Selenocompound metabolism_Homo sapiens_hsa004500.45112444
91FoxO signaling pathway_Homo sapiens_hsa040680.44993398
92Systemic lupus erythematosus_Homo sapiens_hsa053220.44354555
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.44328495
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43145515
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41919429
96Nitrogen metabolism_Homo sapiens_hsa009100.40948679
97Butanoate metabolism_Homo sapiens_hsa006500.40205391
98Calcium signaling pathway_Homo sapiens_hsa040200.38650549
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37640144
100Long-term potentiation_Homo sapiens_hsa047200.37275468

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