GOLGA8G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)8.93157123
2response to pheromone (GO:0019236)8.63683359
3fusion of sperm to egg plasma membrane (GO:0007342)8.16435719
4axonemal dynein complex assembly (GO:0070286)7.27463776
5multicellular organism reproduction (GO:0032504)6.99421040
6spermatid development (GO:0007286)6.87988848
7sperm capacitation (GO:0048240)6.68853167
8cilium or flagellum-dependent cell motility (GO:0001539)6.31423951
9plasma membrane fusion (GO:0045026)6.30843724
10protein polyglutamylation (GO:0018095)6.30154925
11single strand break repair (GO:0000012)6.21964094
12motile cilium assembly (GO:0044458)6.14295344
13sperm-egg recognition (GO:0035036)6.11577056
14epithelial cilium movement (GO:0003351)6.02827163
15centriole replication (GO:0007099)6.01255453
16reproduction (GO:0000003)5.96636569
17spermatid nucleus differentiation (GO:0007289)5.84233205
18chromosome condensation (GO:0030261)5.82079928
19protein targeting to Golgi (GO:0000042)5.78234561
20establishment of protein localization to Golgi (GO:0072600)5.78038556
21DNA packaging (GO:0006323)5.76808942
22cellular ketone body metabolic process (GO:0046950)5.50039156
23cilium movement (GO:0003341)5.29413652
24spermatogenesis (GO:0007283)5.28278834
25male gamete generation (GO:0048232)5.26149017
26microtubule depolymerization (GO:0007019)5.24931960
27retrograde transport, vesicle recycling within Golgi (GO:0000301)5.18830339
28phosphatidylethanolamine biosynthetic process (GO:0006646)5.14750998
29calcium ion-dependent exocytosis (GO:0017156)5.11187363
30centriole assembly (GO:0098534)5.05330114
31cell-cell recognition (GO:0009988)5.00606100
32microtubule polymerization or depolymerization (GO:0031109)4.96112624
33single fertilization (GO:0007338)4.95894972
34binding of sperm to zona pellucida (GO:0007339)4.94822665
35microtubule severing (GO:0051013)4.93749561
36phosphatidylethanolamine metabolic process (GO:0046337)4.90131481
37ketone body metabolic process (GO:1902224)4.85814798
38regulation of cilium movement (GO:0003352)4.84034641
39gamete generation (GO:0007276)4.83524876
40epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.68971330
41cell wall macromolecule metabolic process (GO:0044036)4.59746967
42negative regulation of inclusion body assembly (GO:0090084)4.59188365
43rRNA methylation (GO:0031167)4.58880135
44seminiferous tubule development (GO:0072520)4.55817515
45protein localization to Golgi apparatus (GO:0034067)4.39273712
46cell wall macromolecule catabolic process (GO:0016998)4.38736330
47piRNA metabolic process (GO:0034587)4.23401684
48fertilization (GO:0009566)4.17839907
49axoneme assembly (GO:0035082)4.10412005
50germ cell development (GO:0007281)4.10135495
51sexual reproduction (GO:0019953)4.06939749
52RNA destabilization (GO:0050779)4.01516361
53rRNA modification (GO:0000154)3.89567755
54multicellular organismal reproductive process (GO:0048609)3.81610477
55cellular process involved in reproduction in multicellular organism (GO:0022412)3.58930488
56urinary tract smooth muscle contraction (GO:0014848)3.56754079
57positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.44951571
58regulation of Rab GTPase activity (GO:0032313)3.42723308
59positive regulation of Rab GTPase activity (GO:0032851)3.42723308
60regulation of microtubule-based movement (GO:0060632)3.39754630
61regulation of centriole replication (GO:0046599)3.24273165
62organic cation transport (GO:0015695)3.24030040
63detection of light stimulus involved in visual perception (GO:0050908)3.20389012
64detection of light stimulus involved in sensory perception (GO:0050962)3.20389012
65musculoskeletal movement (GO:0050881)3.13903047
66multicellular organismal movement (GO:0050879)3.13903047
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.05490396
68microtubule nucleation (GO:0007020)3.05272580
69DNA methylation involved in gamete generation (GO:0043046)3.03941580
70glomerular visceral epithelial cell development (GO:0072015)3.00910530
71chromatin silencing (GO:0006342)3.00432970
72nucleus organization (GO:0006997)2.99456971
73neuronal action potential (GO:0019228)2.98606908
74behavioral response to nicotine (GO:0035095)2.98148279
75male meiosis (GO:0007140)2.95910232
76cilium organization (GO:0044782)2.93402968
77detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.91134622
78regulation of inclusion body assembly (GO:0090083)2.91120316
79negative regulation of Rho protein signal transduction (GO:0035024)2.90155934
80glomerular epithelial cell development (GO:0072310)2.88921281
81cilium assembly (GO:0042384)2.88837754
82male meiosis I (GO:0007141)2.80943537
83negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.80459137
84indole-containing compound catabolic process (GO:0042436)2.79002517
85indolalkylamine catabolic process (GO:0046218)2.79002517
86tryptophan catabolic process (GO:0006569)2.79002517
87post-embryonic morphogenesis (GO:0009886)2.75866547
88regulation of transcription involved in cell fate commitment (GO:0060850)2.75566124
89coenzyme catabolic process (GO:0009109)2.74495578
90multicellular organismal development (GO:0007275)2.69836749
91spinal cord motor neuron differentiation (GO:0021522)2.66435650
92sleep (GO:0030431)2.64423259
93regulation of phosphoprotein phosphatase activity (GO:0043666)2.63003765
94ventricular system development (GO:0021591)2.61634276
95positive regulation of action potential (GO:0045760)2.59819075
96cellular response to pH (GO:0071467)2.58837337
97G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.57384407
98membrane depolarization during action potential (GO:0086010)2.53654679
99termination of G-protein coupled receptor signaling pathway (GO:0038032)2.50961150
100sperm motility (GO:0030317)10.0974886

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.87532080
2EZH2_22144423_ChIP-Seq_EOC_Human3.77277451
3VDR_22108803_ChIP-Seq_LS180_Human2.68438649
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.61350262
5CTBP2_25329375_ChIP-Seq_LNCAP_Human2.55232678
6CTBP1_25329375_ChIP-Seq_LNCAP_Human2.54280554
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.38861507
8TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20561907
9POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.20561907
10ZNF274_21170338_ChIP-Seq_K562_Hela2.19916678
11IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.18790319
12CBP_20019798_ChIP-Seq_JUKART_Human2.18790319
13FUS_26573619_Chip-Seq_HEK293_Human2.17088046
14ER_23166858_ChIP-Seq_MCF-7_Human1.97577652
15TAF15_26573619_Chip-Seq_HEK293_Human1.92989249
16P300_19829295_ChIP-Seq_ESCs_Human1.91926678
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86928171
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.86126730
19GBX2_23144817_ChIP-Seq_PC3_Human1.85677170
20DROSHA_22980978_ChIP-Seq_HELA_Human1.85629177
21* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.78764708
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.73849583
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70957613
24AR_25329375_ChIP-Seq_VCAP_Human1.63745657
25NANOG_20526341_ChIP-Seq_ESCs_Human1.58080191
26EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.52138560
27SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52006254
28ERA_21632823_ChIP-Seq_H3396_Human1.51787444
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50272142
30WDR5_24793694_ChIP-Seq_LNCAP_Human1.49013373
31RAC3_21632823_ChIP-Seq_H3396_Human1.47254327
32SMAD4_21741376_ChIP-Seq_EPCs_Human1.43108681
33SMAD3_21741376_ChIP-Seq_EPCs_Human1.41910318
34NANOG_19829295_ChIP-Seq_ESCs_Human1.41392977
35SOX2_19829295_ChIP-Seq_ESCs_Human1.41392977
36SMAD4_21799915_ChIP-Seq_A2780_Human1.40987501
37TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40790442
38STAT3_23295773_ChIP-Seq_U87_Human1.40250353
39TAF2_19829295_ChIP-Seq_ESCs_Human1.39529374
40AUTS2_25519132_ChIP-Seq_293T-REX_Human1.39523344
41RUNX2_22187159_ChIP-Seq_PCA_Human1.39119204
42RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.36801019
43MYC_19829295_ChIP-Seq_ESCs_Human1.34096071
44EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.32221878
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30730375
46GATA3_21878914_ChIP-Seq_MCF-7_Human1.28435512
47PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.27849538
48VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.27397096
49TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.26954328
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26612859
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25813646
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25810618
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24858930
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.24858930
55ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24319018
56ARNT_22903824_ChIP-Seq_MCF-7_Human1.23160002
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.23057594
58PRDM14_20953172_ChIP-Seq_ESCs_Human1.22786594
59KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22390384
60FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22377109
61REST_21632747_ChIP-Seq_MESCs_Mouse1.21959727
62SMAD3_21741376_ChIP-Seq_ESCs_Human1.21845740
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20338551
64NCOR_22424771_ChIP-Seq_293T_Human1.20013658
65OCT4_20526341_ChIP-Seq_ESCs_Human1.19827761
66HOXB7_26014856_ChIP-Seq_BT474_Human1.19093171
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.17350370
68EED_16625203_ChIP-ChIP_MESCs_Mouse1.16898858
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16431421
70TCF4_23295773_ChIP-Seq_U87_Human1.15826010
71PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.13983524
72SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13955088
73IGF1R_20145208_ChIP-Seq_DFB_Human1.13941805
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12036581
75ERG_20517297_ChIP-Seq_VCAP_Human1.11588656
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10349482
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10227838
78RBPJ_21746931_ChIP-Seq_IB4_Human1.08693387
79FLI1_27457419_Chip-Seq_LIVER_Mouse1.08451494
80CBX2_22325352_ChIP-Seq_293T-Rex_Human1.08158984
81CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07479094
82CEBPB_22108803_ChIP-Seq_LS180_Human1.07327546
83EZH2_27304074_Chip-Seq_ESCs_Mouse1.06610897
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06223165
85ETV1_20927104_ChIP-Seq_GIST48_Human1.03863888
86OCT1_27270436_Chip-Seq_PROSTATE_Human1.03840878
87SMRT_27268052_Chip-Seq_Bcells_Human1.03620506
88TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.02892738
89RXR_22108803_ChIP-Seq_LS180_Human1.02688075
90TP53_18474530_ChIP-ChIP_U2OS_Human1.02525038
91RNF2_27304074_Chip-Seq_NSC_Mouse1.02511625
92CTCF_20526341_ChIP-Seq_ESCs_Human1.01749470
93ELF1_20517297_ChIP-Seq_JURKAT_Human1.01595426
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01504627
95JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01384188
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00132697
97HNFA_21074721_ChIP-Seq_CACO-2_Human0.99798027
98SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.99598979
99CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.98502705
100P53_21459846_ChIP-Seq_SAOS-2_Human0.98136028

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.72139780
2MP0005377_hearing/vestibular/ear_phenot4.14224329
3MP0003878_abnormal_ear_physiology4.14224329
4MP0003646_muscle_fatigue3.54693876
5MP0003136_yellow_coat_color3.50333893
6MP0003698_abnormal_male_reproductive3.42860150
7MP0001929_abnormal_gametogenesis3.04171197
8MP0001968_abnormal_touch/_nociception2.82783104
9MP0005551_abnormal_eye_electrophysiolog2.11945277
10MP0001348_abnormal_lacrimal_gland2.08973580
11MP0005670_abnormal_white_adipose2.03305692
12MP0003718_maternal_effect2.02846170
13MP0003879_abnormal_hair_cell2.01909684
14MP0001485_abnormal_pinna_reflex2.01176401
15MP0002735_abnormal_chemical_nociception1.95303650
16MP0001486_abnormal_startle_reflex1.94886659
17MP0002234_abnormal_pharynx_morphology1.80501194
18MP0002161_abnormal_fertility/fecundity1.79945977
19MP0002102_abnormal_ear_morphology1.77377944
20MP0001986_abnormal_taste_sensitivity1.76566539
21MP0008877_abnormal_DNA_methylation1.59183077
22MP0002736_abnormal_nociception_after1.58161144
23MP0002210_abnormal_sex_determination1.57279699
24MP0002733_abnormal_thermal_nociception1.48619254
25MP0003880_abnormal_central_pattern1.47170397
26MP0005379_endocrine/exocrine_gland_phen1.43212519
27MP0005253_abnormal_eye_physiology1.40072500
28MP0003011_delayed_dark_adaptation1.38624480
29MP0006072_abnormal_retinal_apoptosis1.34016864
30MP0002876_abnormal_thyroid_physiology1.33845424
31MP0002282_abnormal_trachea_morphology1.32515934
32MP0009745_abnormal_behavioral_response1.30948607
33MP0002272_abnormal_nervous_system1.30190999
34MP0005671_abnormal_response_to1.29962003
35MP0001963_abnormal_hearing_physiology1.29163810
36MP0001970_abnormal_pain_threshold1.29091107
37MP0002138_abnormal_hepatobiliary_system1.26524084
38MP0004742_abnormal_vestibular_system1.23360488
39MP0005423_abnormal_somatic_nervous1.22574228
40MP0008995_early_reproductive_senescence1.21360505
41MP0004859_abnormal_synaptic_plasticity1.20817128
42MP0000653_abnormal_sex_gland1.19865568
43MP0000026_abnormal_inner_ear1.17652037
44MP0002653_abnormal_ependyma_morphology1.17522955
45MP0001501_abnormal_sleep_pattern1.16905690
46MP0002734_abnormal_mechanical_nocicepti1.11219835
47MP0001145_abnormal_male_reproductive1.09632140
48MP0004147_increased_porphyrin_level1.09579007
49MP0006276_abnormal_autonomic_nervous1.09341302
50MP0001984_abnormal_olfaction1.07796112
51MP0001765_abnormal_ion_homeostasis1.07616436
52MP0002067_abnormal_sensory_capabilities1.05378988
53MP0002572_abnormal_emotion/affect_behav1.04630930
54MP0005310_abnormal_salivary_gland1.00846028
55MP0000678_abnormal_parathyroid_gland0.99279331
56MP0002249_abnormal_larynx_morphology0.98939746
57MP0008872_abnormal_physiological_respon0.98599993
58MP0003638_abnormal_response/metabolism_0.95587226
59MP0005167_abnormal_blood-brain_barrier0.95386297
60MP0003959_abnormal_lean_body0.94157012
61MP0000372_irregular_coat_pigmentation0.93401076
62MP0002557_abnormal_social/conspecific_i0.92396139
63MP0002132_abnormal_respiratory_system0.91574114
64MP0003195_calcinosis0.90224983
65MP0002229_neurodegeneration0.88990873
66MP0005395_other_phenotype0.87469552
67MP0005645_abnormal_hypothalamus_physiol0.86640001
68MP0000230_abnormal_systemic_arterial0.86610340
69MP0005646_abnormal_pituitary_gland0.84579338
70MP0009046_muscle_twitch0.82978627
71MP0002095_abnormal_skin_pigmentation0.82610541
72MP0006292_abnormal_olfactory_placode0.80799144
73MP0003635_abnormal_synaptic_transmissio0.78923661
74MP0004885_abnormal_endolymph0.78757113
75MP0005085_abnormal_gallbladder_physiolo0.78125936
76MP0010329_abnormal_lipoprotein_level0.77400803
77MP0002928_abnormal_bile_duct0.77151648
78MP0002127_abnormal_cardiovascular_syste0.76739603
79MP0002822_catalepsy0.74483893
80MP0000427_abnormal_hair_cycle0.74408930
81MP0008775_abnormal_heart_ventricle0.72236876
82MP0001440_abnormal_grooming_behavior0.72198408
83MP0009697_abnormal_copulation0.68190420
84MP0005636_abnormal_mineral_homeostasis0.67713524
85MP0000049_abnormal_middle_ear0.66206764
86MP0010386_abnormal_urinary_bladder0.65083507
87MP0003252_abnormal_bile_duct0.64778032
88MP0005171_absent_coat_pigmentation0.64762980
89MP0000566_synostosis0.64444867
90MP0005195_abnormal_posterior_eye0.64275145
91MP0004085_abnormal_heartbeat0.61812299
92MP0005084_abnormal_gallbladder_morpholo0.61714669
93MP0004142_abnormal_muscle_tone0.61622849
94MP0001879_abnormal_lymphatic_vessel0.60952967
95MP0004036_abnormal_muscle_relaxation0.59833944
96MP0004484_altered_response_of0.58725613
97MP0009278_abnormal_bone_marrow0.58619979
98MP0002064_seizures0.58146483
99MP0000631_abnormal_neuroendocrine_gland0.57164507
100MP0009764_decreased_sensitivity_to0.57121695

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)6.20707440
2Absent/shortened dynein arms (HP:0200106)6.20707440
3Chronic hepatic failure (HP:0100626)5.80631834
4Abnormal ciliary motility (HP:0012262)5.41817441
5Abnormal respiratory motile cilium morphology (HP:0005938)5.31135961
6Abnormal respiratory epithelium morphology (HP:0012253)5.31135961
7Abnormal respiratory motile cilium physiology (HP:0012261)4.98594092
8Severe visual impairment (HP:0001141)4.68333491
9Tubulointerstitial nephritis (HP:0001970)4.34697075
10Attenuation of retinal blood vessels (HP:0007843)4.28244114
11Bony spicule pigmentary retinopathy (HP:0007737)4.06776836
12Congenital stationary night blindness (HP:0007642)4.02850399
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.97849592
14Pancreatic cysts (HP:0001737)3.74076645
15Nephronophthisis (HP:0000090)3.71738747
16Abnormality of macular pigmentation (HP:0008002)3.66238654
17Nasal polyposis (HP:0100582)3.52120103
18Chronic sinusitis (HP:0011109)3.32619953
19Infertility (HP:0000789)3.28426572
20Progressive cerebellar ataxia (HP:0002073)3.27194703
21Pancreatic fibrosis (HP:0100732)3.25649552
22True hermaphroditism (HP:0010459)3.20772012
23Rhinitis (HP:0012384)3.07294392
24Polydipsia (HP:0001959)3.05124881
25Abnormal drinking behavior (HP:0030082)3.05124881
26Abnormality of the renal medulla (HP:0100957)2.99677107
27Abnormal rod and cone electroretinograms (HP:0008323)2.98834887
28Azoospermia (HP:0000027)2.96304271
29Abnormal spermatogenesis (HP:0008669)2.95796899
30Hyperkalemia (HP:0002153)2.94513612
31Potter facies (HP:0002009)2.92652212
32Facial shape deformation (HP:0011334)2.92652212
33Tubular atrophy (HP:0000092)2.89650540
34Abnormality of midbrain morphology (HP:0002418)2.89508806
35Molar tooth sign on MRI (HP:0002419)2.89508806
36Cone-rod dystrophy (HP:0000548)2.89286569
37Cystic liver disease (HP:0006706)2.82733428
38Abnormality of the nasal mucosa (HP:0000433)2.81944682
39Generalized aminoaciduria (HP:0002909)2.77161713
40Decreased central vision (HP:0007663)2.72498932
41Tubulointerstitial abnormality (HP:0001969)2.66391219
42Male infertility (HP:0003251)2.62606884
43Sclerocornea (HP:0000647)2.60164476
44Occipital encephalocele (HP:0002085)2.60132859
45Stage 5 chronic kidney disease (HP:0003774)2.60131729
46Asymmetric septal hypertrophy (HP:0001670)2.58674159
47Abnormal urine output (HP:0012590)2.53540051
48Type II lissencephaly (HP:0007260)2.49175671
49Bronchiectasis (HP:0002110)2.46211866
50Optic nerve hypoplasia (HP:0000609)2.45926356
51Polyuria (HP:0000103)2.45886932
52Amelogenesis imperfecta (HP:0000705)2.44885415
53Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.37488569
54Portal hypertension (HP:0001409)2.29087857
55Chronic bronchitis (HP:0004469)2.28960669
56Congenital hepatic fibrosis (HP:0002612)2.21681561
57Abnormality of renal excretion (HP:0011036)2.18479030
58Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.17678186
59Congenital sensorineural hearing impairment (HP:0008527)2.17567746
60Abnormality of dental color (HP:0011073)2.15472267
61Decreased circulating renin level (HP:0003351)2.15404056
62Abnormality of the renal cortex (HP:0011035)2.15075266
63Cerebellar dysplasia (HP:0007033)2.10883551
64Abnormality of the hepatic vasculature (HP:0006707)2.06125210
65Protruding tongue (HP:0010808)2.04845746
66Horizontal nystagmus (HP:0000666)2.02569449
67Aplasia/Hypoplasia of the earlobes (HP:0009906)2.02323660
68Scotoma (HP:0000575)2.00316765
69Abolished electroretinogram (ERG) (HP:0000550)2.00265930
70Anencephaly (HP:0002323)1.99906646
71Genetic anticipation (HP:0003743)1.97917331
72Abnormality of potassium homeostasis (HP:0011042)1.96940786
73Medial flaring of the eyebrow (HP:0010747)1.92500120
74Increased corneal curvature (HP:0100692)1.92403462
75Keratoconus (HP:0000563)1.92403462
76Hypoplasia of the thymus (HP:0000778)1.89645227
77Abnormal albumin level (HP:0012116)1.84584203
78Hypoalbuminemia (HP:0003073)1.84584203
79Macular degeneration (HP:0000608)1.84209226
80Supernumerary spleens (HP:0009799)1.83995651
81Male pseudohermaphroditism (HP:0000037)1.83932424
82Postural instability (HP:0002172)1.83373480
83Glycosuria (HP:0003076)1.82049267
84Abnormality of urine glucose concentration (HP:0011016)1.82049267
85Enlarged epiphyses (HP:0010580)1.80926148
86Hyperventilation (HP:0002883)1.79830103
87Photophobia (HP:0000613)1.76746388
88Abnormality of the costochondral junction (HP:0000919)1.74046445
89Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.73570205
90Intellectual disability, moderate (HP:0002342)1.72820893
91Menstrual irregularities (HP:0000858)1.72586526
92Pigmentary retinal degeneration (HP:0001146)1.72142890
93Renal dysplasia (HP:0000110)1.69442619
94Bronchitis (HP:0012387)1.67053174
95Decreased electroretinogram (ERG) amplitude (HP:0000654)1.66928832
96Truncal obesity (HP:0001956)1.66771499
97Abnormality of the fovea (HP:0000493)1.66640797
98Aplasia/Hypoplasia of the fovea (HP:0008060)1.65089649
99Hypoplasia of the fovea (HP:0007750)1.65089649
100Renal Fanconi syndrome (HP:0001994)1.63073763

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK45.88145722
2INSRR5.72032160
3TESK24.60905047
4MUSK3.00046551
5PNCK2.86731945
6MAP4K22.82736880
7FRK2.80746817
8GRK12.72668443
9TESK12.58950627
10MAPK152.50423177
11TIE12.40600201
12PLK22.36862291
13ZAK2.28773481
14CASK2.25827936
15ADRBK22.15821695
16TLK12.05826304
17BRD41.96012379
18MAPKAPK31.87795830
19PIK3CG1.76528083
20DDR21.75422475
21STK38L1.70706988
22LATS11.62505437
23STK381.43285856
24SIK21.40597426
25PTK2B1.39710604
26TAOK31.36106126
27PINK11.34765838
28PRKD31.31319404
29MAP3K41.20525652
30WNK41.16322440
31TXK1.07966650
32CAMK1G1.07859183
33ACVR1B0.97388197
34TYRO30.89421098
35BMPR1B0.86181435
36KDR0.80771947
37ITK0.78061280
38NEK60.76398183
39STK390.73778850
40WNK10.69413110
41PDK10.69054969
42TEC0.67747983
43MAPK130.66907580
44STK160.64294153
45PRKCG0.62094519
46AKT30.61994165
47ADRBK10.60968666
48CDK70.60519926
49PDPK10.60440127
50NUAK10.58658326
51MAP3K20.54703570
52GRK70.54633421
53KSR20.53605790
54MAP2K70.49766991
55WNK30.49244299
56KIT0.47460849
57SYK0.47217908
58OXSR10.46717829
59PRKCE0.46157813
60CCNB10.44063427
61MARK10.42336281
62MST1R0.41532704
63PRKG10.41489845
64PRKAA20.41268192
65IRAK10.37850458
66TRPM70.37301032
67CAMK2A0.36975977
68DYRK30.36807138
69DYRK1B0.36313428
70MAP3K110.36057315
71PRKG20.35936735
72CAMK10.35855496
73STK30.33857699
74PRKACA0.33465069
75NTRK30.32039395
76CSNK1G20.31772013
77MAP2K40.28870389
78BCKDK0.27480491
79NTRK20.25899495
80SGK2230.25768365
81SGK4940.25768365
82CSNK1G30.24146221
83IKBKB0.23736902
84CDK190.23532294
85PRKCQ0.23516892
86CAMK1D0.23451789
87RPS6KA50.21934924
88CDK80.21787481
89MAP3K130.21583743
90JAK30.19849906
91CSNK1A1L0.19703662
92RPS6KA10.19444807
93EIF2AK30.17767305
94PRKCB0.16886066
95VRK10.15096437
96PKN10.14293780
97PRKCA0.13998331
98IGF1R0.13885638
99FER0.13843534
100CHUK0.13689958

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.89502716
2Fatty acid biosynthesis_Homo sapiens_hsa000613.99521038
3Phototransduction_Homo sapiens_hsa047443.63997705
4Olfactory transduction_Homo sapiens_hsa047403.44892304
5Taste transduction_Homo sapiens_hsa047422.61961351
6Butanoate metabolism_Homo sapiens_hsa006502.50054180
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.41357413
8Linoleic acid metabolism_Homo sapiens_hsa005912.18294692
9Nicotine addiction_Homo sapiens_hsa050332.17859059
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.16289753
11Graft-versus-host disease_Homo sapiens_hsa053322.08261133
12Allograft rejection_Homo sapiens_hsa053301.96734305
13Autoimmune thyroid disease_Homo sapiens_hsa053201.96339086
14Type I diabetes mellitus_Homo sapiens_hsa049401.77184293
15Nitrogen metabolism_Homo sapiens_hsa009101.75150003
16Antigen processing and presentation_Homo sapiens_hsa046121.68948183
17ABC transporters_Homo sapiens_hsa020101.64892353
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.62047231
19Glycerophospholipid metabolism_Homo sapiens_hsa005641.43919412
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.38670686
21Asthma_Homo sapiens_hsa053101.34983330
22Cardiac muscle contraction_Homo sapiens_hsa042601.34766162
23Morphine addiction_Homo sapiens_hsa050321.31594147
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.30558531
25Serotonergic synapse_Homo sapiens_hsa047261.29308154
26Dorso-ventral axis formation_Homo sapiens_hsa043201.29168298
27Basal transcription factors_Homo sapiens_hsa030221.29064557
28Calcium signaling pathway_Homo sapiens_hsa040201.27450898
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.27273568
30Tryptophan metabolism_Homo sapiens_hsa003801.22326395
31Glutamatergic synapse_Homo sapiens_hsa047241.22063370
32Hedgehog signaling pathway_Homo sapiens_hsa043401.07068874
33Propanoate metabolism_Homo sapiens_hsa006401.06488846
34Ether lipid metabolism_Homo sapiens_hsa005651.05225641
35Circadian entrainment_Homo sapiens_hsa047131.03843503
36Salivary secretion_Homo sapiens_hsa049701.02135701
37Selenocompound metabolism_Homo sapiens_hsa004501.01657915
38Huntingtons disease_Homo sapiens_hsa050160.97910446
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97430568
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97142420
41Steroid hormone biosynthesis_Homo sapiens_hsa001400.94964332
42Ovarian steroidogenesis_Homo sapiens_hsa049130.89123846
43Type II diabetes mellitus_Homo sapiens_hsa049300.88251213
44Chemical carcinogenesis_Homo sapiens_hsa052040.87378277
45Fatty acid degradation_Homo sapiens_hsa000710.87138897
46Primary immunodeficiency_Homo sapiens_hsa053400.86467789
47PPAR signaling pathway_Homo sapiens_hsa033200.84868109
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83558821
49Glycerolipid metabolism_Homo sapiens_hsa005610.83298142
50Retinol metabolism_Homo sapiens_hsa008300.81833397
51GABAergic synapse_Homo sapiens_hsa047270.79035268
52Fat digestion and absorption_Homo sapiens_hsa049750.76699842
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76556804
54Viral myocarditis_Homo sapiens_hsa054160.75786530
55Arachidonic acid metabolism_Homo sapiens_hsa005900.75298543
56cAMP signaling pathway_Homo sapiens_hsa040240.73738446
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.69903672
58RNA transport_Homo sapiens_hsa030130.67383940
59Oxidative phosphorylation_Homo sapiens_hsa001900.67283466
60Purine metabolism_Homo sapiens_hsa002300.67072056
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64559997
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59981381
63Fatty acid metabolism_Homo sapiens_hsa012120.59544689
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58793906
65Oxytocin signaling pathway_Homo sapiens_hsa049210.54135974
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.53143076
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52225315
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51412375
69Caffeine metabolism_Homo sapiens_hsa002320.50159530
70Protein digestion and absorption_Homo sapiens_hsa049740.49154473
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48604501
72beta-Alanine metabolism_Homo sapiens_hsa004100.48409059
73Arginine and proline metabolism_Homo sapiens_hsa003300.48228320
74Long-term depression_Homo sapiens_hsa047300.47226023
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45615103
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45046070
77RNA polymerase_Homo sapiens_hsa030200.44216027
78Regulation of autophagy_Homo sapiens_hsa041400.42589777
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42206347
80Fanconi anemia pathway_Homo sapiens_hsa034600.41198606
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38776084
82MAPK signaling pathway_Homo sapiens_hsa040100.38200046
83Hematopoietic cell lineage_Homo sapiens_hsa046400.38029517
84Synaptic vesicle cycle_Homo sapiens_hsa047210.37644936
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35183959
86Insulin secretion_Homo sapiens_hsa049110.35008012
87Mineral absorption_Homo sapiens_hsa049780.34242511
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34131105
89Phenylalanine metabolism_Homo sapiens_hsa003600.33447951
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32947521
91Bile secretion_Homo sapiens_hsa049760.32855202
92One carbon pool by folate_Homo sapiens_hsa006700.32566215
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31678568
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31391051
95Endocytosis_Homo sapiens_hsa041440.29490439
96Histidine metabolism_Homo sapiens_hsa003400.29089747
97Pancreatic secretion_Homo sapiens_hsa049720.28782223
98Influenza A_Homo sapiens_hsa051640.28712473
99Metabolic pathways_Homo sapiens_hsa011000.28535239
100Parkinsons disease_Homo sapiens_hsa050120.26363568

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