GOLGA6L6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)9.77605894
2sperm capacitation (GO:0048240)9.19721126
3chromosome condensation (GO:0030261)8.86514271
4DNA packaging (GO:0006323)8.70017198
5single strand break repair (GO:0000012)8.53598530
6spermatid nucleus differentiation (GO:0007289)8.06706441
7plasma membrane fusion (GO:0045026)7.76523944
8spermatid development (GO:0007286)7.70264726
9microtubule depolymerization (GO:0007019)7.10783822
10sexual reproduction (GO:0019953)6.99204151
11sperm-egg recognition (GO:0035036)6.91626616
12multicellular organism reproduction (GO:0032504)6.54206911
13calcium ion-dependent exocytosis (GO:0017156)6.43791052
14reproduction (GO:0000003)6.43262297
15protein polyglutamylation (GO:0018095)6.38489400
16phosphatidylethanolamine biosynthetic process (GO:0006646)6.23430262
17binding of sperm to zona pellucida (GO:0007339)6.20995930
18microtubule polymerization or depolymerization (GO:0031109)6.07805152
19axonemal dynein complex assembly (GO:0070286)5.98053035
20rRNA methylation (GO:0031167)5.85671771
21negative regulation of inclusion body assembly (GO:0090084)5.83113883
22phosphatidylethanolamine metabolic process (GO:0046337)5.79720152
23cell-cell recognition (GO:0009988)5.70921683
24regulation of Rab GTPase activity (GO:0032313)5.67389795
25positive regulation of Rab GTPase activity (GO:0032851)5.67389795
26microtubule severing (GO:0051013)5.67319753
27protein targeting to Golgi (GO:0000042)5.66426656
28establishment of protein localization to Golgi (GO:0072600)5.59602235
29spermatogenesis (GO:0007283)5.57908344
30male gamete generation (GO:0048232)5.56184146
31centriole replication (GO:0007099)5.52158363
32cellular ketone body metabolic process (GO:0046950)5.41598989
33retrograde transport, vesicle recycling within Golgi (GO:0000301)5.27974627
34regulation of cilium movement (GO:0003352)5.26153664
35chromatin silencing (GO:0006342)5.12521791
36gamete generation (GO:0007276)5.07551636
37regulation of transcription involved in cell fate commitment (GO:0060850)5.07245440
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.95758397
39cilium or flagellum-dependent cell motility (GO:0001539)4.93476307
40rRNA modification (GO:0000154)4.82206162
41ketone body metabolic process (GO:1902224)4.76616788
42motile cilium assembly (GO:0044458)4.74042349
43centriole assembly (GO:0098534)4.67286306
44cell wall macromolecule metabolic process (GO:0044036)4.54806321
45single fertilization (GO:0007338)4.44356807
46germ cell development (GO:0007281)4.40853343
47cell wall macromolecule catabolic process (GO:0016998)4.27084075
48RNA destabilization (GO:0050779)4.24595594
49cellular process involved in reproduction in multicellular organism (GO:0022412)4.22384873
50regulation of inclusion body assembly (GO:0090083)4.12622591
51protein localization to Golgi apparatus (GO:0034067)4.09942031
52regulation of centriole replication (GO:0046599)4.09534896
53multicellular organismal reproductive process (GO:0048609)4.05990422
54coenzyme catabolic process (GO:0009109)3.91673213
55epithelial cilium movement (GO:0003351)3.87099405
56nucleus organization (GO:0006997)3.79405653
57peptidyl-threonine dephosphorylation (GO:0035970)3.76730622
58musculoskeletal movement (GO:0050881)3.76409677
59multicellular organismal movement (GO:0050879)3.76409677
60cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.75823567
61fertilization (GO:0009566)3.68352244
62organic cation transport (GO:0015695)3.63893310
63negative regulation of Rho protein signal transduction (GO:0035024)3.62858558
64regulation of microtubule-based movement (GO:0060632)3.60832251
65cerebral cortex neuron differentiation (GO:0021895)3.53238932
66mesenchymal cell differentiation involved in renal system development (GO:2001012)3.51041969
67mesenchymal cell differentiation involved in kidney development (GO:0072161)3.51041969
68cilium movement (GO:0003341)3.49972473
69negative regulation of gene expression, epigenetic (GO:0045814)3.49269765
70response to acidic pH (GO:0010447)3.48175629
71seminiferous tubule development (GO:0072520)3.39646779
72NAD biosynthetic process (GO:0009435)3.35937909
73protein-DNA complex disassembly (GO:0032986)3.35767147
74nucleosome disassembly (GO:0006337)3.35767147
75cellular response to pH (GO:0071467)3.33338005
76cranial nerve morphogenesis (GO:0021602)3.16482535
77regulation of somitogenesis (GO:0014807)3.14493446
78glycerol ether metabolic process (GO:0006662)3.10383527
79regulation of interleukin-13 production (GO:0032656)3.09563937
80regulation of ARF GTPase activity (GO:0032312)3.06940507
81regulation of female gonad development (GO:2000194)3.06698246
82regulation of T-helper 2 cell differentiation (GO:0045628)3.05311331
83Golgi to endosome transport (GO:0006895)3.03444232
84polyamine biosynthetic process (GO:0006596)3.00179112
85histone H3-K9 demethylation (GO:0033169)2.97884984
86homeostasis of number of cells within a tissue (GO:0048873)2.94681846
87multicellular organismal development (GO:0007275)2.92617433
88negative regulation of histone methylation (GO:0031061)2.88622481
89DNA methylation involved in gamete generation (GO:0043046)2.88009376
90ether metabolic process (GO:0018904)2.86455673
91cell differentiation involved in metanephros development (GO:0072202)2.85482342
92cell recognition (GO:0008037)2.81323921
93receptor recycling (GO:0001881)2.78342734
94peptidyl-proline hydroxylation (GO:0019511)2.78255069
95alanine transport (GO:0032328)2.76885196
96regulation of interleukin-5 production (GO:0032674)2.71427109
97DNA conformation change (GO:0071103)2.70478365
98acrosome reaction (GO:0007340)11.6986117
99sperm motility (GO:0030317)11.1684424
100fusion of sperm to egg plasma membrane (GO:0007342)10.2659980

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.40517408
2EZH2_22144423_ChIP-Seq_EOC_Human3.60575723
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.16072436
4DROSHA_22980978_ChIP-Seq_HELA_Human2.33661043
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.30827379
6TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30827379
7* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17216044
8ELF1_20517297_ChIP-Seq_JURKAT_Human1.97948057
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.97785284
10CBP_20019798_ChIP-Seq_JUKART_Human1.97700251
11IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.97700251
12EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.91990122
13RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.87157319
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83760485
15* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83521139
16* ERA_21632823_ChIP-Seq_H3396_Human1.81744455
17CTCF_27219007_Chip-Seq_Bcells_Human1.78785797
18NANOG_20526341_ChIP-Seq_ESCs_Human1.77285310
19EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.73530084
20RAC3_21632823_ChIP-Seq_H3396_Human1.72115172
21E2F1_20622854_ChIP-Seq_HELA_Human1.69461967
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67889009
23SMC4_20622854_ChIP-Seq_HELA_Human1.67294393
24BCL6_27268052_Chip-Seq_Bcells_Human1.66894119
25* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.62085351
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61639499
27EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.60946400
28P68_20966046_ChIP-Seq_HELA_Human1.60096547
29PHF8_20622854_ChIP-Seq_HELA_Human1.59171620
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56015031
31TDRD3_21172665_ChIP-Seq_MCF-7_Human1.55913105
32BCOR_27268052_Chip-Seq_Bcells_Human1.55899184
33* WDR5_24793694_ChIP-Seq_LNCAP_Human1.52319688
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52093739
35TAF2_19829295_ChIP-Seq_ESCs_Human1.51173361
36* OCT4_20526341_ChIP-Seq_ESCs_Human1.48915886
37CTCF_20526341_ChIP-Seq_ESCs_Human1.48024493
38MYC_19829295_ChIP-Seq_ESCs_Human1.46088049
39ETV2_25802403_ChIP-Seq_MESCs_Mouse1.45252360
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.42912078
41TP63_22573176_ChIP-Seq_HFKS_Human1.41792672
42* ER_23166858_ChIP-Seq_MCF-7_Human1.40703436
43LXR_22292898_ChIP-Seq_THP-1_Human1.40305382
44YY1_22570637_ChIP-Seq_MALME-3M_Human1.39000067
45SMAD4_21741376_ChIP-Seq_EPCs_Human1.38846241
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38403794
47SMAD3_21741376_ChIP-Seq_ESCs_Human1.37736892
48P300_27268052_Chip-Seq_Bcells_Human1.37458800
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.37357550
50SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.35216869
51* AR_25329375_ChIP-Seq_VCAP_Human1.34982781
52FUS_26573619_Chip-Seq_HEK293_Human1.33766892
53AUTS2_25519132_ChIP-Seq_293T-REX_Human1.33457418
54PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.32423288
55GATA3_21878914_ChIP-Seq_MCF-7_Human1.31394703
56SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30278908
57P53_21459846_ChIP-Seq_SAOS-2_Human1.23081228
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22945669
59P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.22522291
60CEBPB_22108803_ChIP-Seq_LS180_Human1.21255214
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20648710
62P300_19829295_ChIP-Seq_ESCs_Human1.18642903
63ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18232208
64SMAD4_21741376_ChIP-Seq_HESCs_Human1.17088184
65HNFA_21074721_ChIP-Seq_CACO-2_Human1.16963200
66KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.16465008
67ERG_20517297_ChIP-Seq_VCAP_Human1.15333274
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.14991371
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14765524
70REST_21632747_ChIP-Seq_MESCs_Mouse1.14357897
71SOX2_22085726_ChIP-Seq_NPCs_Mouse1.14231820
72CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.14090965
73RBPJ_21746931_ChIP-Seq_IB4_Human1.13796746
74TP53_18474530_ChIP-ChIP_U2OS_Human1.13460051
75EZH2_27304074_Chip-Seq_ESCs_Mouse1.13078211
76CBX2_22325352_ChIP-Seq_293T-Rex_Human1.11959380
77JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11266430
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10747655
79ETV1_20927104_ChIP-Seq_GIST48_Human1.10274829
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10103001
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.09754057
82TAF15_26573619_Chip-Seq_HEK293_Human1.08969306
83SA1_27219007_Chip-Seq_Bcells_Human1.08687918
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07303251
85OCT4_19829295_ChIP-Seq_ESCs_Human1.06501680
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06480493
87NFYB_21822215_ChIP-Seq_K562_Human1.05391236
88TBL1_22424771_ChIP-Seq_293T_Human1.04749864
89NANOG_19829295_ChIP-Seq_ESCs_Human1.03456773
90SOX2_19829295_ChIP-Seq_ESCs_Human1.03456773
91* SMRT_27268052_Chip-Seq_Bcells_Human1.02823958
92OCT1_27270436_Chip-Seq_PROSTATE_Human1.02152103
93* RUNX2_22187159_ChIP-Seq_PCA_Human1.01974563
94TP63_19390658_ChIP-ChIP_HaCaT_Human1.01349778
95HOXB7_26014856_ChIP-Seq_BT474_Human1.01208073
96FOXH1_21741376_ChIP-Seq_ESCs_Human1.00812285
97STAT3_23295773_ChIP-Seq_U87_Human1.00536907
98PHF8_20622853_ChIP-Seq_HELA_Human0.99246185
99PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98970102
100SMAD4_21799915_ChIP-Seq_A2780_Human0.98896382

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.12545479
2MP0003878_abnormal_ear_physiology5.12545479
3MP0005670_abnormal_white_adipose5.05216458
4MP0003698_abnormal_male_reproductive4.11158608
5MP0001348_abnormal_lacrimal_gland4.09502629
6MP0001929_abnormal_gametogenesis3.44483368
7MP0000678_abnormal_parathyroid_gland2.64547827
8MP0002822_catalepsy2.48673349
9MP0003646_muscle_fatigue2.37585726
10MP0002161_abnormal_fertility/fecundity2.27394143
11MP0005410_abnormal_fertilization11.3680675
12MP0003718_maternal_effect1.93093340
13MP0005379_endocrine/exocrine_gland_phen1.91574875
14MP0002735_abnormal_chemical_nociception1.76042909
15MP0002249_abnormal_larynx_morphology1.72657494
16MP0002132_abnormal_respiratory_system1.68213967
17MP0002234_abnormal_pharynx_morphology1.66605798
18MP0005423_abnormal_somatic_nervous1.63177960
19MP0001486_abnormal_startle_reflex1.59409984
20MP0001485_abnormal_pinna_reflex1.57479694
21MP0009053_abnormal_anal_canal1.57138480
22MP0003879_abnormal_hair_cell1.54401004
23MP0003011_delayed_dark_adaptation1.53187557
24MP0002210_abnormal_sex_determination1.52867342
25MP0002138_abnormal_hepatobiliary_system1.45121679
26MP0000534_abnormal_ureter_morphology1.34107808
27MP0001968_abnormal_touch/_nociception1.32243833
28MP0001145_abnormal_male_reproductive1.22295717
29MP0000653_abnormal_sex_gland1.19721297
30MP0002282_abnormal_trachea_morphology1.19640147
31MP0004859_abnormal_synaptic_plasticity1.18850284
32MP0001963_abnormal_hearing_physiology1.17325023
33MP0001765_abnormal_ion_homeostasis1.14337795
34MP0004742_abnormal_vestibular_system1.13500189
35MP0002653_abnormal_ependyma_morphology1.12864440
36MP0002733_abnormal_thermal_nociception1.11110193
37MP0000026_abnormal_inner_ear1.09247762
38MP0005395_other_phenotype1.07199895
39MP0001905_abnormal_dopamine_level1.05696446
40MP0008569_lethality_at_weaning1.02668024
41MP0009745_abnormal_behavioral_response0.98826696
42MP0005310_abnormal_salivary_gland0.97514833
43MP0001501_abnormal_sleep_pattern0.96406778
44MP0002127_abnormal_cardiovascular_syste0.95278307
45MP0002229_neurodegeneration0.94785959
46MP0005248_abnormal_Harderian_gland0.91930827
47MP0005451_abnormal_body_composition0.91456426
48MP0000955_abnormal_spinal_cord0.90938958
49MP0002067_abnormal_sensory_capabilities0.90580494
50MP0002557_abnormal_social/conspecific_i0.90520948
51MP0004510_myositis0.89394878
52MP0005551_abnormal_eye_electrophysiolog0.88630290
53MP0004233_abnormal_muscle_weight0.88078184
54MP0000681_abnormal_thyroid_gland0.87464648
55MP0003136_yellow_coat_color0.87423279
56MP0000049_abnormal_middle_ear0.87167137
57MP0001440_abnormal_grooming_behavior0.87079441
58MP0002837_dystrophic_cardiac_calcinosis0.85778549
59MP0001970_abnormal_pain_threshold0.84467789
60MP0002572_abnormal_emotion/affect_behav0.83790646
61MP0009115_abnormal_fat_cell0.81078018
62MP0004085_abnormal_heartbeat0.78249091
63MP0005666_abnormal_adipose_tissue0.77377754
64MP0002272_abnormal_nervous_system0.71037652
65MP0002734_abnormal_mechanical_nocicepti0.68205171
66MP0003119_abnormal_digestive_system0.67473263
67MP0006276_abnormal_autonomic_nervous0.67081049
68MP0003137_abnormal_impulse_conducting0.64785415
69MP0006292_abnormal_olfactory_placode0.63884304
70MP0005375_adipose_tissue_phenotype0.63225550
71MP0003635_abnormal_synaptic_transmissio0.62545304
72MP0005535_abnormal_body_temperature0.62335226
73MP0005167_abnormal_blood-brain_barrier0.59865187
74MP0008877_abnormal_DNA_methylation0.59165502
75MP0005253_abnormal_eye_physiology0.58980267
76MP0000470_abnormal_stomach_morphology0.58883379
77MP0001879_abnormal_lymphatic_vessel0.58872247
78MP0002168_other_aberrant_phenotype0.55049436
79MP0009046_muscle_twitch0.54176173
80MP0005083_abnormal_biliary_tract0.52023406
81MP0009697_abnormal_copulation0.51763063
82MP0002928_abnormal_bile_duct0.51284176
83MP0008961_abnormal_basal_metabolism0.50981802
84MP0003045_fibrosis0.50431825
85MP0001666_abnormal_nutrient_absorption0.49853349
86MP0005636_abnormal_mineral_homeostasis0.47696383
87MP0000516_abnormal_urinary_system0.47133516
88MP0005367_renal/urinary_system_phenotyp0.47133516
89MP0002064_seizures0.45502315
90MP0000003_abnormal_adipose_tissue0.45404359
91MP0004484_altered_response_of0.44282019
92MP0002882_abnormal_neuron_morphology0.43387329
93MP0003942_abnormal_urinary_system0.43058833
94MP0003880_abnormal_central_pattern0.42854706
95MP0000569_abnormal_digit_pigmentation0.40339320
96MP0005647_abnormal_sex_gland0.38748035
97MP0003699_abnormal_female_reproductive0.38373684
98MP0002752_abnormal_somatic_nervous0.36678454
99MP0003631_nervous_system_phenotype0.36274520
100MP0004036_abnormal_muscle_relaxation0.35957404

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.29999937
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.85510856
3Absent/shortened dynein arms (HP:0200106)5.85510856
4Bony spicule pigmentary retinopathy (HP:0007737)5.32844164
5Attenuation of retinal blood vessels (HP:0007843)5.19498342
6Asymmetric septal hypertrophy (HP:0001670)5.17098611
7Abnormal ciliary motility (HP:0012262)4.64425454
8Bell-shaped thorax (HP:0001591)4.53451434
9Facial shape deformation (HP:0011334)4.49546907
10Potter facies (HP:0002009)4.49546907
11Hyperkalemia (HP:0002153)4.49520253
12Abnormal respiratory motile cilium physiology (HP:0012261)4.35092037
13Abnormal respiratory motile cilium morphology (HP:0005938)4.34953348
14Abnormal respiratory epithelium morphology (HP:0012253)4.34953348
15Hypoplastic ischia (HP:0003175)4.27932456
16Abnormal rod and cone electroretinograms (HP:0008323)4.06083782
17Abnormality of macular pigmentation (HP:0008002)3.95239861
18Infertility (HP:0000789)3.88796901
19Male infertility (HP:0003251)3.88435981
20Resting tremor (HP:0002322)3.84471597
21Progressive cerebellar ataxia (HP:0002073)3.82678805
22Tubulointerstitial nephritis (HP:0001970)3.81377146
23Abnormality of the ischium (HP:0003174)3.76946841
24Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.73217693
25Chronic hepatic failure (HP:0100626)3.70606222
26Enlarged epiphyses (HP:0010580)3.61554448
27Nasal polyposis (HP:0100582)3.60471433
28Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.56662132
29Impulsivity (HP:0100710)3.48346004
30Postural instability (HP:0002172)3.35727642
31Aplasia/Hypoplasia of the earlobes (HP:0009906)3.34376429
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.31884054
33Unilateral renal agenesis (HP:0000122)3.19328989
34Amelogenesis imperfecta (HP:0000705)3.17956331
35Nephronophthisis (HP:0000090)3.06316568
36Abnormal spermatogenesis (HP:0008669)3.05579831
37Azoospermia (HP:0000027)3.01630791
38Cone-rod dystrophy (HP:0000548)3.00893020
39Abnormal urine output (HP:0012590)2.97907371
40Abnormality of the nasal mucosa (HP:0000433)2.85534304
41Abnormality of potassium homeostasis (HP:0011042)2.83312678
42Genetic anticipation (HP:0003743)2.74314268
43Double outlet right ventricle (HP:0001719)2.64914217
44Congenital malformation of the right heart (HP:0011723)2.64914217
45Renal dysplasia (HP:0000110)2.61537567
46Abnormality of the renal medulla (HP:0100957)2.60754351
47Polydipsia (HP:0001959)2.58249959
48Abnormal drinking behavior (HP:0030082)2.58249959
49Hypoplasia of the thymus (HP:0000778)2.58202877
50Abnormality of the aortic arch (HP:0012303)2.57988309
51Abnormality of renal excretion (HP:0011036)2.57907960
52Rhinitis (HP:0012384)2.47492701
53Epiphyseal dysplasia (HP:0002656)2.44825501
54Polyuria (HP:0000103)2.42561013
55Abnormality of the pubic bones (HP:0003172)2.39386105
56Stage 5 chronic kidney disease (HP:0003774)2.34233982
57Generalized aminoaciduria (HP:0002909)2.32367685
58Portal hypertension (HP:0001409)2.28146566
59Abnormality of the costochondral junction (HP:0000919)2.22461701
60Tubulointerstitial abnormality (HP:0001969)2.21437347
61Truncal obesity (HP:0001956)2.20335771
62Decreased central vision (HP:0007663)2.18938784
63Abnormality of the parathyroid morphology (HP:0011766)2.18005655
64Widely patent fontanelles and sutures (HP:0004492)2.10819482
65Abnormality of dental color (HP:0011073)2.07994704
66Progressive sensorineural hearing impairment (HP:0000408)2.07045609
67Abnormality of the hepatic vasculature (HP:0006707)2.05903400
68Bronchiectasis (HP:0002110)2.05585394
69Retinal dysplasia (HP:0007973)2.04105593
70Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.02701314
71Absent epiphyses (HP:0010577)2.02701314
72Aplasia/Hypoplasia of the sacrum (HP:0008517)2.00897314
73Hypophosphatemic rickets (HP:0004912)1.98059476
74Mixed hearing impairment (HP:0000410)1.95788601
75Hypokalemia (HP:0002900)1.94912223
76Tubular atrophy (HP:0000092)1.93131527
77Renovascular hypertension (HP:0100817)1.91973328
78Hyperthyroidism (HP:0000836)1.91908740
79Neoplasm of the heart (HP:0100544)1.90803924
80Hyponatremia (HP:0002902)1.90729947
81Tetany (HP:0001281)1.89050545
82Abnormality of the epiphysis of the femoral head (HP:0010574)1.88402681
83Spastic paraparesis (HP:0002313)1.85806138
84Cerebellar dysplasia (HP:0007033)1.85105056
85Flattened epiphyses (HP:0003071)1.84703615
86Hypoalphalipoproteinemia (HP:0003233)1.83553812
87Congenital sensorineural hearing impairment (HP:0008527)1.82195558
88Abnormal ventriculo-arterial connection (HP:0011563)1.81057314
89Transposition of the great arteries (HP:0001669)1.81057314
90Abnormal connection of the cardiac segments (HP:0011545)1.81057314
91Ventricular tachycardia (HP:0004756)1.80568720
92Short ribs (HP:0000773)1.77208176
93Insulin-resistant diabetes mellitus (HP:0000831)1.74922881
94Abnormality of femoral epiphyses (HP:0006499)1.74569369
95Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.74569369
96Chronic bronchitis (HP:0004469)1.72054851
97Osteomalacia (HP:0002749)1.71960635
98Photophobia (HP:0000613)1.71247471
99Atelectasis (HP:0100750)1.71156557
100Myokymia (HP:0002411)1.70966620

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.58643336
2TESK16.03923472
3DDR25.07925122
4STK383.69349973
5INSRR3.42399278
6STK38L3.32819224
7MAP4K22.78571836
8PLK22.69258892
9PRKD32.57135414
10MAPK152.52363583
11PNCK2.39205916
12LATS12.20771773
13CAMK1G2.10040249
14LATS22.01624321
15BRD41.93820060
16MST1R1.86330385
17PDPK11.76314354
18WNK11.57842834
19FRK1.46853020
20PDK11.43661763
21PIK3CG1.37097830
22SIK21.35735054
23CDK71.30782995
24CDK121.20476149
25MAP3K91.20221987
26PTK2B1.20002041
27DYRK1B1.17955335
28BMPR1B1.03691630
29PRKAA20.98307673
30PRKG20.97116622
31MAP2K20.94296029
32KSR20.90892622
33CAMK1D0.88205238
34NEK60.85217255
35WNK40.83977969
36AKT30.81373320
37RPS6KA20.74269924
38UHMK10.73472934
39ACVR1B0.70613835
40PRKG10.68356468
41RPS6KA10.63474376
42NTRK30.62484333
43MAP3K20.60063125
44BRAF0.56888533
45ZAK0.56509075
46STK390.50568664
47RPS6KA60.48329966
48MAP3K110.48025029
49PRKCG0.47436042
50NEK20.47290159
51GSK3B0.45992309
52MAP3K80.45827646
53CAMK10.45628131
54RPS6KL10.43118027
55RPS6KC10.43118027
56CDK30.40996415
57MTOR0.40854470
58CDK20.40685537
59ROCK10.40130972
60MARK10.39382761
61MAPK10.39195760
62ADRBK20.38973564
63CDK40.38831109
64MAPK80.38797490
65ICK0.37451678
66RIPK40.37364656
67PKN10.37227912
68SGK2230.36936595
69SGK4940.36936595
70CDK10.36306752
71MUSK0.34617126
72TYRO30.34208180
73OXSR10.33888508
74TNK20.32756065
75MAPK110.31891166
76TAF10.30029294
77SGK10.28293170
78CAMK40.28063654
79MARK20.28010860
80PRKCE0.27189889
81MET0.26686700
82PRKCB0.26200509
83PRKCZ0.25918530
84TESK20.25479334
85CHEK10.24134139
86PRKAA10.23296557
87FER0.23142770
88STK30.22922916
89MAPK140.21729218
90AKT10.20872704
91MAP3K10.19916172
92GRK70.17682882
93MAP3K40.15298888
94JAK30.14361286
95MAPK100.13961605
96STK160.13906198
97PRKACB0.13378156
98PRKACA0.13204345
99PRKCH0.12959360
100IKBKB0.10998812

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.79557707
2Fatty acid biosynthesis_Homo sapiens_hsa000615.08370846
3Olfactory transduction_Homo sapiens_hsa047403.54775100
4Butanoate metabolism_Homo sapiens_hsa006502.60093435
5Taste transduction_Homo sapiens_hsa047422.22353212
6Glycerophospholipid metabolism_Homo sapiens_hsa005641.97567020
7Dorso-ventral axis formation_Homo sapiens_hsa043201.93293459
8Phototransduction_Homo sapiens_hsa047441.84120153
9Nicotine addiction_Homo sapiens_hsa050331.74821457
10Type II diabetes mellitus_Homo sapiens_hsa049301.71064342
11Morphine addiction_Homo sapiens_hsa050321.65009274
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.64938403
13Type I diabetes mellitus_Homo sapiens_hsa049401.64632796
14Graft-versus-host disease_Homo sapiens_hsa053321.59679458
15Allograft rejection_Homo sapiens_hsa053301.59139336
16Autoimmune thyroid disease_Homo sapiens_hsa053201.58117960
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.49888366
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.41389716
19Fatty acid degradation_Homo sapiens_hsa000711.38832586
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.32649126
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.31261142
22Phenylalanine metabolism_Homo sapiens_hsa003601.26797640
23Circadian entrainment_Homo sapiens_hsa047131.23948415
24Viral myocarditis_Homo sapiens_hsa054161.23202506
25Antigen processing and presentation_Homo sapiens_hsa046121.22915140
26Selenocompound metabolism_Homo sapiens_hsa004501.19638959
27Arginine and proline metabolism_Homo sapiens_hsa003301.18849626
28Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.18687710
29Calcium signaling pathway_Homo sapiens_hsa040201.18427740
30ABC transporters_Homo sapiens_hsa020101.17026892
31Salivary secretion_Homo sapiens_hsa049701.14778019
32Synaptic vesicle cycle_Homo sapiens_hsa047211.09394877
33Fatty acid metabolism_Homo sapiens_hsa012121.09281201
34GABAergic synapse_Homo sapiens_hsa047271.04413723
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.03420537
36Adipocytokine signaling pathway_Homo sapiens_hsa049201.00856946
37cAMP signaling pathway_Homo sapiens_hsa040240.99004722
38Glutamatergic synapse_Homo sapiens_hsa047240.97424219
39Protein digestion and absorption_Homo sapiens_hsa049740.97398641
40Glycerolipid metabolism_Homo sapiens_hsa005610.93064369
41Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89452481
42Gastric acid secretion_Homo sapiens_hsa049710.87901563
43Endocytosis_Homo sapiens_hsa041440.87491752
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84891705
45Cholinergic synapse_Homo sapiens_hsa047250.84605481
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83331748
47Insulin secretion_Homo sapiens_hsa049110.81925186
48Estrogen signaling pathway_Homo sapiens_hsa049150.81903093
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81791582
50Fat digestion and absorption_Homo sapiens_hsa049750.79745739
51Inositol phosphate metabolism_Homo sapiens_hsa005620.77364261
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.75813710
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.74990094
54PPAR signaling pathway_Homo sapiens_hsa033200.74510704
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74381364
56Serotonergic synapse_Homo sapiens_hsa047260.74177199
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73819514
58Cardiac muscle contraction_Homo sapiens_hsa042600.73757697
59Bile secretion_Homo sapiens_hsa049760.73077561
60Renin-angiotensin system_Homo sapiens_hsa046140.71273427
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68457230
62Oocyte meiosis_Homo sapiens_hsa041140.66131471
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64949566
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63489390
65Retinol metabolism_Homo sapiens_hsa008300.62605576
66RNA transport_Homo sapiens_hsa030130.61948210
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61917014
68Hedgehog signaling pathway_Homo sapiens_hsa043400.61797504
69Arginine biosynthesis_Homo sapiens_hsa002200.60709507
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59720152
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57834012
72VEGF signaling pathway_Homo sapiens_hsa043700.56772497
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54240437
74Oxytocin signaling pathway_Homo sapiens_hsa049210.53793259
75Tyrosine metabolism_Homo sapiens_hsa003500.51288573
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50114995
77Renin secretion_Homo sapiens_hsa049240.49616690
78Lysine degradation_Homo sapiens_hsa003100.46175456
79Influenza A_Homo sapiens_hsa051640.43724701
80Purine metabolism_Homo sapiens_hsa002300.43181279
81Basal transcription factors_Homo sapiens_hsa030220.43165497
82Tight junction_Homo sapiens_hsa045300.41701482
83Nitrogen metabolism_Homo sapiens_hsa009100.41521174
84MAPK signaling pathway_Homo sapiens_hsa040100.39840997
85Sphingolipid metabolism_Homo sapiens_hsa006000.39388715
86Linoleic acid metabolism_Homo sapiens_hsa005910.38716181
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34799905
88Acute myeloid leukemia_Homo sapiens_hsa052210.33039295
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30371349
90ECM-receptor interaction_Homo sapiens_hsa045120.30244484
91Tryptophan metabolism_Homo sapiens_hsa003800.30112259
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.29716367
93Pancreatic secretion_Homo sapiens_hsa049720.29692176
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27876920
95Cocaine addiction_Homo sapiens_hsa050300.27736167
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27664706
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.21092170
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.19709243
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19525579
100Prolactin signaling pathway_Homo sapiens_hsa049170.16456304

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