GOLGA6L10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm capacitation (GO:0048240)9.11079463
2chromosome condensation (GO:0030261)9.04733587
3DNA packaging (GO:0006323)8.76686965
4single strand break repair (GO:0000012)8.51605439
5spermatid nucleus differentiation (GO:0007289)8.45901636
6plasma membrane fusion (GO:0045026)7.95581642
7spermatid development (GO:0007286)7.71820034
8microtubule depolymerization (GO:0007019)7.57100858
9sperm-egg recognition (GO:0035036)7.11205494
10multicellular organism reproduction (GO:0032504)6.63743795
11axonemal dynein complex assembly (GO:0070286)6.58861781
12protein polyglutamylation (GO:0018095)6.54977892
13binding of sperm to zona pellucida (GO:0007339)6.40573748
14sexual reproduction (GO:0019953)6.39516875
15rRNA methylation (GO:0031167)6.36219856
16calcium ion-dependent exocytosis (GO:0017156)6.34308266
17reproduction (GO:0000003)6.34054673
18microtubule polymerization or depolymerization (GO:0031109)6.30815362
19protein targeting to Golgi (GO:0000042)6.11799377
20phosphatidylethanolamine biosynthetic process (GO:0006646)6.09077853
21establishment of protein localization to Golgi (GO:0072600)5.92951768
22cell-cell recognition (GO:0009988)5.83540216
23negative regulation of inclusion body assembly (GO:0090084)5.73428751
24spermatogenesis (GO:0007283)5.73124033
25male gamete generation (GO:0048232)5.71325552
26centriole replication (GO:0007099)5.69125731
27retrograde transport, vesicle recycling within Golgi (GO:0000301)5.68737358
28phosphatidylethanolamine metabolic process (GO:0046337)5.62369078
29cellular ketone body metabolic process (GO:0046950)5.42991108
30rRNA modification (GO:0000154)5.37266012
31regulation of cilium movement (GO:0003352)5.33953872
32microtubule severing (GO:0051013)5.33259259
33positive regulation of Rab GTPase activity (GO:0032851)5.26657740
34regulation of Rab GTPase activity (GO:0032313)5.26657740
35gamete generation (GO:0007276)5.22840489
36cilium or flagellum-dependent cell motility (GO:0001539)4.87486202
37regulation of transcription involved in cell fate commitment (GO:0060850)4.80792836
38ketone body metabolic process (GO:1902224)4.77088268
39motile cilium assembly (GO:0044458)4.76381968
40chromatin silencing (GO:0006342)4.74504776
41centriole assembly (GO:0098534)4.74341776
42cell wall macromolecule catabolic process (GO:0016998)4.61046553
43single fertilization (GO:0007338)4.55026100
44RNA destabilization (GO:0050779)4.54509994
45epithelial cilium movement (GO:0003351)4.54329329
46cell wall macromolecule metabolic process (GO:0044036)4.54238256
47protein localization to Golgi apparatus (GO:0034067)4.51711091
48regulation of centriole replication (GO:0046599)4.48331187
49germ cell development (GO:0007281)4.37632349
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.32455224
51regulation of inclusion body assembly (GO:0090083)4.21743083
52cellular process involved in reproduction in multicellular organism (GO:0022412)4.20861314
53multicellular organismal reproductive process (GO:0048609)4.16460577
54coenzyme catabolic process (GO:0009109)4.04135595
55cilium movement (GO:0003341)3.94295533
56nucleus organization (GO:0006997)3.90655086
57fertilization (GO:0009566)3.80437641
58regulation of microtubule-based movement (GO:0060632)3.80434295
59seminiferous tubule development (GO:0072520)3.76855878
60negative regulation of Rho protein signal transduction (GO:0035024)3.67555984
61musculoskeletal movement (GO:0050881)3.56894510
62multicellular organismal movement (GO:0050879)3.56894510
63organic cation transport (GO:0015695)3.51247486
64epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.39373717
65peptidyl-threonine dephosphorylation (GO:0035970)3.38927083
66negative regulation of gene expression, epigenetic (GO:0045814)3.35706076
67regulation of somitogenesis (GO:0014807)3.34139587
68glycerol ether metabolic process (GO:0006662)3.33696156
69cerebral cortex neuron differentiation (GO:0021895)3.33405404
70protein-DNA complex disassembly (GO:0032986)3.31280080
71nucleosome disassembly (GO:0006337)3.31280080
72cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.24338714
73negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.20830969
74cranial nerve morphogenesis (GO:0021602)3.20460884
75polyamine biosynthetic process (GO:0006596)3.12579294
76response to acidic pH (GO:0010447)3.10629621
77ether metabolic process (GO:0018904)3.07174838
78mesenchymal cell differentiation involved in kidney development (GO:0072161)3.06889827
79mesenchymal cell differentiation involved in renal system development (GO:2001012)3.06889827
80histone H3-K9 demethylation (GO:0033169)3.06385978
81cell recognition (GO:0008037)3.03830687
82negative regulation of histone methylation (GO:0031061)3.03743360
83cellular response to pH (GO:0071467)3.00795161
84microtubule nucleation (GO:0007020)2.92228025
85multicellular organismal development (GO:0007275)2.91833507
86DNA conformation change (GO:0071103)2.88132163
87homeostasis of number of cells within a tissue (GO:0048873)2.82888747
88Golgi to endosome transport (GO:0006895)2.82850950
89regulation of interleukin-13 production (GO:0032656)2.82782913
90protein depolymerization (GO:0051261)2.79889193
91histone exchange (GO:0043486)2.79111216
92cell differentiation involved in metanephros development (GO:0072202)2.78772711
93male meiosis I (GO:0007141)2.76586269
94pattern specification involved in kidney development (GO:0061004)2.73641043
95spinal cord motor neuron differentiation (GO:0021522)2.71459474
96regulation of phosphoprotein phosphatase activity (GO:0043666)2.69340300
97acrosome reaction (GO:0007340)11.7125255
98sperm motility (GO:0030317)11.1681615
99fusion of sperm to egg plasma membrane (GO:0007342)10.3699557
100response to pheromone (GO:0019236)10.0529171

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.85764690
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.01098129
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.69285901
4TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52573869
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.52573869
6EZH2_22144423_ChIP-Seq_EOC_Human2.48881908
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.47019388
8CTBP1_25329375_ChIP-Seq_LNCAP_Human2.25479124
9IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.24240955
10CBP_20019798_ChIP-Seq_JUKART_Human2.24240955
11FUS_26573619_Chip-Seq_HEK293_Human2.19667945
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92321391
13* ERA_21632823_ChIP-Seq_H3396_Human1.90549930
14WDR5_24793694_ChIP-Seq_LNCAP_Human1.86768261
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86710403
16DROSHA_22980978_ChIP-Seq_HELA_Human1.86691211
17ELF1_20517297_ChIP-Seq_JURKAT_Human1.85796457
18NANOG_20526341_ChIP-Seq_ESCs_Human1.82609952
19ZNF274_21170338_ChIP-Seq_K562_Hela1.82465391
20EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.82245549
21RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.82167980
22UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.80253206
23ER_23166858_ChIP-Seq_MCF-7_Human1.76604490
24* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.75955635
25* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.73121954
26RAC3_21632823_ChIP-Seq_H3396_Human1.72908890
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.71301528
28CTCF_27219007_Chip-Seq_Bcells_Human1.64905283
29TAF15_26573619_Chip-Seq_HEK293_Human1.61216425
30MYC_19829295_ChIP-Seq_ESCs_Human1.60311011
31TAF2_19829295_ChIP-Seq_ESCs_Human1.60213873
32AR_25329375_ChIP-Seq_VCAP_Human1.57256246
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.54831651
34ETV2_25802403_ChIP-Seq_MESCs_Mouse1.54751096
35SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53441478
36TDRD3_21172665_ChIP-Seq_MCF-7_Human1.52837254
37* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.50485503
38SMAD4_21741376_ChIP-Seq_EPCs_Human1.49052974
39E2F1_20622854_ChIP-Seq_HELA_Human1.48330645
40AUTS2_25519132_ChIP-Seq_293T-REX_Human1.48247872
41BCL6_27268052_Chip-Seq_Bcells_Human1.45623045
42ARNT_22903824_ChIP-Seq_MCF-7_Human1.45318197
43OCT4_20526341_ChIP-Seq_ESCs_Human1.45172890
44EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.43595291
45YY1_22570637_ChIP-Seq_MALME-3M_Human1.43475674
46PHF8_20622854_ChIP-Seq_HELA_Human1.42613895
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42573175
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.40614043
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.39708030
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36981548
51* P300_19829295_ChIP-Seq_ESCs_Human1.36547553
52AR_21572438_ChIP-Seq_LNCaP_Human1.36372317
53CTCF_20526341_ChIP-Seq_ESCs_Human1.35439630
54ERG_20517297_ChIP-Seq_VCAP_Human1.33131253
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32744817
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.32504659
57HNFA_21074721_ChIP-Seq_CACO-2_Human1.31033355
58P68_20966046_ChIP-Seq_HELA_Human1.30363039
59* SMC4_20622854_ChIP-Seq_HELA_Human1.30096810
60* SMAD3_21741376_ChIP-Seq_ESCs_Human1.29443220
61CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.28646574
62RBPJ_21746931_ChIP-Seq_IB4_Human1.28024488
63BCOR_27268052_Chip-Seq_Bcells_Human1.27826639
64CBX2_22325352_ChIP-Seq_293T-Rex_Human1.27664694
65ETV1_20927104_ChIP-Seq_GIST48_Human1.26889986
66PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.26885274
67TP53_18474530_ChIP-ChIP_U2OS_Human1.26264085
68TP63_22573176_ChIP-Seq_HFKS_Human1.25203014
69* GATA3_21878914_ChIP-Seq_MCF-7_Human1.24991736
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24125748
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23026682
72P300_27268052_Chip-Seq_Bcells_Human1.21672983
73RUNX2_22187159_ChIP-Seq_PCA_Human1.21646210
74SOX2_22085726_ChIP-Seq_NPCs_Mouse1.21501783
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21232232
76P53_21459846_ChIP-Seq_SAOS-2_Human1.19880809
77CEBPB_22108803_ChIP-Seq_LS180_Human1.19562549
78NFYB_21822215_ChIP-Seq_K562_Human1.19338636
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18358226
80TBL1_22424771_ChIP-Seq_293T_Human1.17797889
81SMAD4_21741376_ChIP-Seq_HESCs_Human1.14576981
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14421478
83SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13149911
84SOX2_19829295_ChIP-Seq_ESCs_Human1.12951965
85NANOG_19829295_ChIP-Seq_ESCs_Human1.12951965
86VDR_22108803_ChIP-Seq_LS180_Human1.11861247
87PHF8_20622853_ChIP-Seq_HELA_Human1.11650018
88P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.11465782
89KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.09877603
90EZH2_27304074_Chip-Seq_ESCs_Mouse1.09077443
91SMRT_27268052_Chip-Seq_Bcells_Human1.08652611
92REST_21632747_ChIP-Seq_MESCs_Mouse1.08477545
93SMAD4_21799915_ChIP-Seq_A2780_Human1.07916550
94HOXB7_26014856_ChIP-Seq_BT474_Human1.07462429
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06743244
96STAT3_23295773_ChIP-Seq_U87_Human1.06346097
97RUNX1_26923725_Chip-Seq_HPCs_Mouse1.06195980
98OCT1_27270436_Chip-Seq_PROSTATE_Human1.05242947
99TCF4_18268006_ChIP-ChIP_LS174T_Human1.05186078
100GATA6_21074721_ChIP-Seq_CACO-2_Human1.05168831

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot4.79795841
2MP0003878_abnormal_ear_physiology4.79795841
3MP0003698_abnormal_male_reproductive4.23766724
4MP0005670_abnormal_white_adipose3.92051422
5MP0001929_abnormal_gametogenesis3.58969038
6MP0001348_abnormal_lacrimal_gland3.28475163
7MP0000678_abnormal_parathyroid_gland2.42249394
8MP0002161_abnormal_fertility/fecundity2.39211578
9MP0003011_delayed_dark_adaptation2.25644976
10MP0003718_maternal_effect2.15557431
11MP0002234_abnormal_pharynx_morphology2.13689253
12MP0005379_endocrine/exocrine_gland_phen2.00369086
13MP0005410_abnormal_fertilization11.2571243
14MP0005423_abnormal_somatic_nervous1.83146125
15MP0002132_abnormal_respiratory_system1.79637058
16MP0002822_catalepsy1.78005515
17MP0001485_abnormal_pinna_reflex1.73437876
18MP0006292_abnormal_olfactory_placode1.70388641
19MP0002249_abnormal_larynx_morphology1.70256074
20MP0002210_abnormal_sex_determination1.69757406
21MP0003646_muscle_fatigue1.66850413
22MP0001486_abnormal_startle_reflex1.57043276
23MP0002282_abnormal_trachea_morphology1.50919656
24MP0009053_abnormal_anal_canal1.45097873
25MP0001968_abnormal_touch/_nociception1.44760373
26MP0004742_abnormal_vestibular_system1.44580022
27MP0003880_abnormal_central_pattern1.42132029
28MP0001145_abnormal_male_reproductive1.40850939
29MP0002735_abnormal_chemical_nociception1.40382259
30MP0000534_abnormal_ureter_morphology1.34578411
31MP0000653_abnormal_sex_gland1.34460317
32MP0000566_synostosis1.30464183
33MP0004859_abnormal_synaptic_plasticity1.28781607
34MP0008877_abnormal_DNA_methylation1.24833473
35MP0000026_abnormal_inner_ear1.21697508
36MP0002138_abnormal_hepatobiliary_system1.20199640
37MP0000049_abnormal_middle_ear1.19003814
38MP0001963_abnormal_hearing_physiology1.15376659
39MP0000955_abnormal_spinal_cord1.08414824
40MP0002127_abnormal_cardiovascular_syste1.05071129
41MP0005248_abnormal_Harderian_gland1.01092478
42MP0002653_abnormal_ependyma_morphology1.00287448
43MP0001765_abnormal_ion_homeostasis0.99005299
44MP0004510_myositis0.97742854
45MP0005551_abnormal_eye_electrophysiolog0.94661339
46MP0002557_abnormal_social/conspecific_i0.93133529
47MP0005395_other_phenotype0.89143203
48MP0000516_abnormal_urinary_system0.88747665
49MP0005367_renal/urinary_system_phenotyp0.88747665
50MP0002067_abnormal_sensory_capabilities0.88603695
51MP0002733_abnormal_thermal_nociception0.85165771
52MP0003119_abnormal_digestive_system0.83025609
53MP0005310_abnormal_salivary_gland0.82785870
54MP0002229_neurodegeneration0.82289678
55MP0003879_abnormal_hair_cell0.80735998
56MP0005253_abnormal_eye_physiology0.77281656
57MP0002572_abnormal_emotion/affect_behav0.76401433
58MP0001905_abnormal_dopamine_level0.76194813
59MP0004085_abnormal_heartbeat0.74586844
60MP0001879_abnormal_lymphatic_vessel0.74170486
61MP0009697_abnormal_copulation0.74051128
62MP0008995_early_reproductive_senescence0.73492035
63MP0005084_abnormal_gallbladder_morpholo0.72040061
64MP0009745_abnormal_behavioral_response0.72000731
65MP0002272_abnormal_nervous_system0.71629168
66MP0000681_abnormal_thyroid_gland0.70956930
67MP0005408_hypopigmentation0.70570064
68MP0002734_abnormal_mechanical_nocicepti0.69014449
69MP0002928_abnormal_bile_duct0.68278583
70MP0008569_lethality_at_weaning0.66981267
71MP0000569_abnormal_digit_pigmentation0.65455344
72MP0001293_anophthalmia0.64924394
73MP0001970_abnormal_pain_threshold0.64091520
74MP0001440_abnormal_grooming_behavior0.61242792
75MP0005636_abnormal_mineral_homeostasis0.60077562
76MP0004484_altered_response_of0.59373446
77MP0001529_abnormal_vocalization0.56782079
78MP0003136_yellow_coat_color0.56506388
79MP0001666_abnormal_nutrient_absorption0.55647603
80MP0003635_abnormal_synaptic_transmissio0.54901010
81MP0006276_abnormal_autonomic_nervous0.54799729
82MP0005666_abnormal_adipose_tissue0.54769914
83MP0005167_abnormal_blood-brain_barrier0.53900954
84MP0000778_abnormal_nervous_system0.53262656
85MP0008961_abnormal_basal_metabolism0.52406291
86MP0009115_abnormal_fat_cell0.51951633
87MP0000613_abnormal_salivary_gland0.51354177
88MP0005391_vision/eye_phenotype0.51155963
89MP0003936_abnormal_reproductive_system0.49948575
90MP0003283_abnormal_digestive_organ0.49859362
91MP0003137_abnormal_impulse_conducting0.49695150
92MP0001984_abnormal_olfaction0.48859341
93MP0003861_abnormal_nervous_system0.47651769
94MP0008789_abnormal_olfactory_epithelium0.47481480
95MP0002882_abnormal_neuron_morphology0.47363470
96MP0005375_adipose_tissue_phenotype0.46499179
97MP0003942_abnormal_urinary_system0.46228146
98MP0001501_abnormal_sleep_pattern0.45989396
99MP0003699_abnormal_female_reproductive0.45599323
100MP0002752_abnormal_somatic_nervous0.45112779

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.76833117
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.10267946
3Absent/shortened dynein arms (HP:0200106)6.10267946
4Abnormal ciliary motility (HP:0012262)4.92695751
5Bony spicule pigmentary retinopathy (HP:0007737)4.88592545
6Attenuation of retinal blood vessels (HP:0007843)4.87430535
7Abnormal respiratory motile cilium morphology (HP:0005938)4.71214197
8Abnormal respiratory epithelium morphology (HP:0012253)4.71214197
9Abnormal respiratory motile cilium physiology (HP:0012261)4.66131117
10Asymmetric septal hypertrophy (HP:0001670)4.40851681
11Chronic hepatic failure (HP:0100626)4.25816126
12Bell-shaped thorax (HP:0001591)4.23534273
13Abnormal rod and cone electroretinograms (HP:0008323)4.07061607
14Tubulointerstitial nephritis (HP:0001970)4.01370698
15Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.96898729
16Infertility (HP:0000789)3.94151047
17Facial shape deformation (HP:0011334)3.93188257
18Potter facies (HP:0002009)3.93188257
19Hypoplastic ischia (HP:0003175)3.87683621
20Hyperkalemia (HP:0002153)3.85131937
21Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.82701246
22Abnormality of macular pigmentation (HP:0008002)3.78715159
23Male infertility (HP:0003251)3.68447357
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.67053482
25Resting tremor (HP:0002322)3.62690890
26Enlarged epiphyses (HP:0010580)3.53897369
27Impulsivity (HP:0100710)3.47902424
28Nasal polyposis (HP:0100582)3.44139206
29Azoospermia (HP:0000027)3.42902587
30Abnormality of the ischium (HP:0003174)3.39725844
31Abnormal spermatogenesis (HP:0008669)3.30947063
32Nephronophthisis (HP:0000090)3.24713008
33Aplasia/Hypoplasia of the earlobes (HP:0009906)3.22554336
34Abnormal urine output (HP:0012590)3.03567880
35Cone-rod dystrophy (HP:0000548)3.01235935
36Unilateral renal agenesis (HP:0000122)2.93668907
37Renal dysplasia (HP:0000110)2.93239045
38Abnormality of the aortic arch (HP:0012303)2.91254601
39Polydipsia (HP:0001959)2.85910013
40Abnormal drinking behavior (HP:0030082)2.85910013
41Double outlet right ventricle (HP:0001719)2.84821294
42Congenital malformation of the right heart (HP:0011723)2.84821294
43Progressive cerebellar ataxia (HP:0002073)2.84258501
44Abnormality of the renal medulla (HP:0100957)2.75219049
45Abnormality of the nasal mucosa (HP:0000433)2.67552044
46Rhinitis (HP:0012384)2.66688175
47Polyuria (HP:0000103)2.62397378
48Postural instability (HP:0002172)2.62270894
49Abnormality of renal excretion (HP:0011036)2.60558222
50Generalized aminoaciduria (HP:0002909)2.48792462
51Abnormality of the pubic bones (HP:0003172)2.46541018
52Hypoplasia of the thymus (HP:0000778)2.44406162
53Amelogenesis imperfecta (HP:0000705)2.41196449
54Stage 5 chronic kidney disease (HP:0003774)2.38909409
55Abnormality of the parathyroid morphology (HP:0011766)2.37762389
56Abnormality of potassium homeostasis (HP:0011042)2.33281098
57Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.27681687
58Absent epiphyses (HP:0010577)2.27681687
59Aplasia/Hypoplasia of the sacrum (HP:0008517)2.20550234
60Tubulointerstitial abnormality (HP:0001969)2.19824829
61Tetany (HP:0001281)2.18912561
62Bronchiectasis (HP:0002110)2.14733469
63Renal Fanconi syndrome (HP:0001994)2.10456182
64Optic nerve hypoplasia (HP:0000609)2.10370422
65Progressive sensorineural hearing impairment (HP:0000408)2.10338744
66Abnormality of the costochondral junction (HP:0000919)2.10218073
67Truncal obesity (HP:0001956)2.04074038
68Decreased central vision (HP:0007663)2.03285612
69Abnormality of dental color (HP:0011073)2.01195958
70Pancreatic fibrosis (HP:0100732)2.00703562
71Tubular atrophy (HP:0000092)1.99939929
72Epiphyseal dysplasia (HP:0002656)1.98721387
73Occipital encephalocele (HP:0002085)1.98245984
74Portal hypertension (HP:0001409)1.98222614
75Abnormality of the epiphysis of the femoral head (HP:0010574)1.96762766
76Widely patent fontanelles and sutures (HP:0004492)1.94872033
77Flattened epiphyses (HP:0003071)1.91807426
78Osteomalacia (HP:0002749)1.88012268
79Hypophosphatemic rickets (HP:0004912)1.87761243
80Chronic bronchitis (HP:0004469)1.87700092
81Abnormality of femoral epiphyses (HP:0006499)1.83714046
82Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.83714046
83Myokymia (HP:0002411)1.82291580
84Type II lissencephaly (HP:0007260)1.82116606
85Hyponatremia (HP:0002902)1.81982805
86Hypoalphalipoproteinemia (HP:0003233)1.80356384
87Pendular nystagmus (HP:0012043)1.79560473
88Abnormality of the hepatic vasculature (HP:0006707)1.78145036
89Spastic paraparesis (HP:0002313)1.77655826
90Intellectual disability, moderate (HP:0002342)1.77392441
91Abnormality of chloride homeostasis (HP:0011422)1.75745881
92Abnormality of urine glucose concentration (HP:0011016)1.75417269
93Glycosuria (HP:0003076)1.75417269
94Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75272118
95Pancreatic cysts (HP:0001737)1.71649338
96Abnormality of the femoral head (HP:0003368)1.71494610
97Flat capital femoral epiphysis (HP:0003370)1.71294958
98Sclerocornea (HP:0000647)1.71221933
99Mixed hearing impairment (HP:0000410)1.70889476
100Short ribs (HP:0000773)1.70655073

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.96996399
2TESK15.67524494
3DDR24.94965901
4MAP4K23.39112877
5INSRR3.36417271
6PNCK3.34100433
7PLK22.97629789
8STK382.88232960
9MAPK152.79669767
10BRD42.49561944
11CAMK1G2.25854518
12STK38L2.24796234
13MAP3K91.94901461
14PRKD31.94307211
15WNK11.63719693
16MST1R1.42738069
17CDK71.35098273
18PDPK11.30414084
19DYRK1B1.29347944
20PDK11.21087218
21WNK41.14157136
22PIK3CG1.13871494
23CDK121.04111751
24UHMK11.00860604
25PTK2B0.95320936
26MARK10.94634097
27CAMK1D0.87800566
28NEK60.87004046
29TNIK0.86651926
30SIK20.84673417
31BMPR1B0.81278215
32TIE10.75924667
33PRKG10.75535198
34RPS6KA20.75532559
35LATS20.73711221
36KSR20.73017778
37BRAF0.73003956
38WNK30.68838923
39MAP3K40.67386286
40PRKAA20.66396221
41RPS6KA10.65725174
42AKT30.65246254
43PRKG20.64257783
44PRKCG0.62346478
45CAMK10.58851060
46SGK2230.57633024
47SGK4940.57633024
48ROCK10.56271430
49MAP2K20.56028222
50STK390.55834317
51CDK30.55766495
52TYRO30.55535898
53ADRBK20.52024553
54DYRK30.51883522
55GSK3B0.50040019
56DYRK20.49846726
57CDK10.48415596
58CDK20.48274288
59MAP3K110.46449412
60RPS6KA60.45721621
61LATS10.44937539
62PRKCZ0.43583620
63RPS6KC10.43006229
64RPS6KL10.43006229
65MAPK10.41904784
66FRK0.41101794
67MAP2K70.39011368
68BRSK20.38978636
69PINK10.38092809
70ARAF0.37137974
71CDK40.36263190
72CHEK10.36213921
73MAP3K80.36100233
74SGK10.35496397
75MUSK0.33461611
76MAPK80.31632229
77CAMK40.31467162
78OXSR10.30885511
79MKNK20.30365950
80ZAK0.30127146
81PRKCB0.29384590
82GRK10.29326408
83MAPK140.29285405
84PKN10.28967642
85PRKCE0.28334081
86SGK20.28023068
87BRSK10.27776986
88FER0.26483107
89NEK20.24892298
90NTRK30.24675944
91MAPK130.23847233
92VRK10.23803388
93NUAK10.22372193
94AKT10.19787686
95MINK10.19096947
96LMTK20.18783622
97MARK20.18675143
98MTOR0.18609705
99MAP3K20.18443834
100PRKACA0.18249389

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000728.01479091
2Fatty acid biosynthesis_Homo sapiens_hsa000615.27268819
3Olfactory transduction_Homo sapiens_hsa047403.74011288
4Butanoate metabolism_Homo sapiens_hsa006502.95840417
5Taste transduction_Homo sapiens_hsa047422.01552432
6Glycerophospholipid metabolism_Homo sapiens_hsa005641.91410570
7Dorso-ventral axis formation_Homo sapiens_hsa043201.60124115
8Phototransduction_Homo sapiens_hsa047441.58732602
9RNA transport_Homo sapiens_hsa030131.57972096
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.57143165
11Maturity onset diabetes of the young_Homo sapiens_hsa049501.49822560
12Cardiac muscle contraction_Homo sapiens_hsa042601.48073599
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48026902
14Type II diabetes mellitus_Homo sapiens_hsa049301.47695068
15Type I diabetes mellitus_Homo sapiens_hsa049401.39657068
16Fatty acid degradation_Homo sapiens_hsa000711.37685075
17Nicotine addiction_Homo sapiens_hsa050331.32717229
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.32087033
19Arginine and proline metabolism_Homo sapiens_hsa003301.30229748
20Selenocompound metabolism_Homo sapiens_hsa004501.28837163
21Basal transcription factors_Homo sapiens_hsa030221.25192775
22Fatty acid metabolism_Homo sapiens_hsa012121.23499281
23Phenylalanine metabolism_Homo sapiens_hsa003601.23223235
24Allograft rejection_Homo sapiens_hsa053301.19128495
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17591353
26Hedgehog signaling pathway_Homo sapiens_hsa043401.16455324
27Autoimmune thyroid disease_Homo sapiens_hsa053201.16159593
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14252399
29Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.13001818
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11398851
31Morphine addiction_Homo sapiens_hsa050321.08583414
32Salivary secretion_Homo sapiens_hsa049701.08400968
33Protein digestion and absorption_Homo sapiens_hsa049741.07941072
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.05540897
35Graft-versus-host disease_Homo sapiens_hsa053321.03631036
36Antigen processing and presentation_Homo sapiens_hsa046120.98109568
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97287580
38Circadian entrainment_Homo sapiens_hsa047130.97237030
39Huntingtons disease_Homo sapiens_hsa050160.95401454
40Fat digestion and absorption_Homo sapiens_hsa049750.93307306
41ABC transporters_Homo sapiens_hsa020100.92315099
42Oocyte meiosis_Homo sapiens_hsa041140.92122517
43cAMP signaling pathway_Homo sapiens_hsa040240.89950570
44Arginine biosynthesis_Homo sapiens_hsa002200.88859960
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87762271
46Synaptic vesicle cycle_Homo sapiens_hsa047210.87416477
47Calcium signaling pathway_Homo sapiens_hsa040200.84539986
48Purine metabolism_Homo sapiens_hsa002300.84286137
49Nitrogen metabolism_Homo sapiens_hsa009100.81000464
50Linoleic acid metabolism_Homo sapiens_hsa005910.80157778
51Adipocytokine signaling pathway_Homo sapiens_hsa049200.78985291
52Glutamatergic synapse_Homo sapiens_hsa047240.78645722
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78035764
54Endocytosis_Homo sapiens_hsa041440.76308035
55Retinol metabolism_Homo sapiens_hsa008300.75555946
56Glycerolipid metabolism_Homo sapiens_hsa005610.74378459
57Insulin secretion_Homo sapiens_hsa049110.73812657
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72494166
59Viral myocarditis_Homo sapiens_hsa054160.71008210
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68924199
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68062552
62Propanoate metabolism_Homo sapiens_hsa006400.67745702
63Fanconi anemia pathway_Homo sapiens_hsa034600.64195957
64Tyrosine metabolism_Homo sapiens_hsa003500.60530843
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58668914
66Tight junction_Homo sapiens_hsa045300.57758974
67PPAR signaling pathway_Homo sapiens_hsa033200.57418218
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57188641
69Inositol phosphate metabolism_Homo sapiens_hsa005620.57010600
70Bile secretion_Homo sapiens_hsa049760.54642686
71GABAergic synapse_Homo sapiens_hsa047270.54078214
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53396345
73Renin-angiotensin system_Homo sapiens_hsa046140.51808107
74Serotonergic synapse_Homo sapiens_hsa047260.49554514
75Cocaine addiction_Homo sapiens_hsa050300.48777529
76Estrogen signaling pathway_Homo sapiens_hsa049150.48279790
77Gastric acid secretion_Homo sapiens_hsa049710.48172679
78Renin secretion_Homo sapiens_hsa049240.47838731
79Cholinergic synapse_Homo sapiens_hsa047250.44312836
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43490368
81MAPK signaling pathway_Homo sapiens_hsa040100.43232992
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.42920845
83Basal cell carcinoma_Homo sapiens_hsa052170.41985694
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37469658
85Pancreatic secretion_Homo sapiens_hsa049720.34909552
86mRNA surveillance pathway_Homo sapiens_hsa030150.34645267
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33808023
88Metabolic pathways_Homo sapiens_hsa011000.33719750
89Peroxisome_Homo sapiens_hsa041460.31297078
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28067265
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26204220
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.25685553
93Oxytocin signaling pathway_Homo sapiens_hsa049210.24832810
94Amphetamine addiction_Homo sapiens_hsa050310.24574436
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.24495371
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22725091
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.22560369
98Influenza A_Homo sapiens_hsa051640.20381125
99beta-Alanine metabolism_Homo sapiens_hsa004100.19080489
100Circadian rhythm_Homo sapiens_hsa047100.18443611

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