GOLGA6B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is found in a large, low copy repeat sequence or duplicon that is found in multiple copies, which are greater than 90% similar, on chromosome 15. Duplicons are associated with deletions, inversions and other chromosomal rearrangements that underlie genomic disease. This gene is a member of the golgin gene family, whose protein products localize to the Golgi apparatus. The majority of the related gene copies are thought to be transcribed pseudogenes. It is not known whether this gene is a pseudogene or if it encodes a golgin protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)9.87783324
2sperm capacitation (GO:0048240)9.52870188
3chromosome condensation (GO:0030261)9.13255127
4DNA packaging (GO:0006323)8.87508552
5plasma membrane fusion (GO:0045026)8.77306866
6single strand break repair (GO:0000012)8.45580846
7spermatid nucleus differentiation (GO:0007289)7.93098038
8spermatid development (GO:0007286)7.68151175
9microtubule depolymerization (GO:0007019)7.63928918
10sperm-egg recognition (GO:0035036)7.25387876
11protein targeting to Golgi (GO:0000042)6.94074182
12multicellular organism reproduction (GO:0032504)6.87054748
13establishment of protein localization to Golgi (GO:0072600)6.68918048
14sexual reproduction (GO:0019953)6.68374509
15microtubule polymerization or depolymerization (GO:0031109)6.67801831
16reproduction (GO:0000003)6.57968494
17calcium ion-dependent exocytosis (GO:0017156)6.53737506
18retrograde transport, vesicle recycling within Golgi (GO:0000301)6.48425511
19binding of sperm to zona pellucida (GO:0007339)6.46377220
20protein polyglutamylation (GO:0018095)6.42920432
21centriole replication (GO:0007099)6.40937004
22rRNA methylation (GO:0031167)6.31061714
23phosphatidylethanolamine biosynthetic process (GO:0006646)6.18737325
24axonemal dynein complex assembly (GO:0070286)6.12929695
25positive regulation of Rab GTPase activity (GO:0032851)6.10059101
26regulation of Rab GTPase activity (GO:0032313)6.10059101
27cell-cell recognition (GO:0009988)5.98125323
28spermatogenesis (GO:0007283)5.95101635
29male gamete generation (GO:0048232)5.93097023
30phosphatidylethanolamine metabolic process (GO:0046337)5.70616006
31negative regulation of inclusion body assembly (GO:0090084)5.66225054
32gamete generation (GO:0007276)5.41999635
33centriole assembly (GO:0098534)5.40282093
34regulation of transcription involved in cell fate commitment (GO:0060850)5.35798689
35microtubule severing (GO:0051013)5.35374180
36rRNA modification (GO:0000154)5.26300363
37regulation of cilium movement (GO:0003352)5.21292349
38regulation of centriole replication (GO:0046599)5.10237273
39antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.98041281
40protein localization to Golgi apparatus (GO:0034067)4.94401286
41cilium or flagellum-dependent cell motility (GO:0001539)4.85622040
42cellular ketone body metabolic process (GO:0046950)4.84579932
43chromatin silencing (GO:0006342)4.83471891
44cell wall macromolecule metabolic process (GO:0044036)4.77907257
45single fertilization (GO:0007338)4.71302391
46motile cilium assembly (GO:0044458)4.62755863
47cell wall macromolecule catabolic process (GO:0016998)4.55765066
48RNA destabilization (GO:0050779)4.43740753
49seminiferous tubule development (GO:0072520)4.43104195
50germ cell development (GO:0007281)4.41314142
51multicellular organismal reproductive process (GO:0048609)4.33559765
52cellular process involved in reproduction in multicellular organism (GO:0022412)4.32273048
53ketone body metabolic process (GO:1902224)4.26409300
54regulation of inclusion body assembly (GO:0090083)4.08371281
55nucleus organization (GO:0006997)4.04490481
56musculoskeletal movement (GO:0050881)4.01491542
57multicellular organismal movement (GO:0050879)4.01491542
58fertilization (GO:0009566)4.00282076
59epithelial cilium movement (GO:0003351)3.91137555
60Golgi to endosome transport (GO:0006895)3.84061762
61coenzyme catabolic process (GO:0009109)3.78922138
62cerebral cortex neuron differentiation (GO:0021895)3.75666758
63cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.67598217
64organic cation transport (GO:0015695)3.63805675
65negative regulation of Rho protein signal transduction (GO:0035024)3.51972168
66glycerol ether metabolic process (GO:0006662)3.51948297
67regulation of microtubule-based movement (GO:0060632)3.46395452
68cilium movement (GO:0003341)3.45919410
69response to acidic pH (GO:0010447)3.45356793
70peptidyl-threonine dephosphorylation (GO:0035970)3.43698782
71microtubule nucleation (GO:0007020)3.40632598
72negative regulation of gene expression, epigenetic (GO:0045814)3.30179785
73regulation of interleukin-13 production (GO:0032656)3.29186604
74regulation of T-helper 2 cell differentiation (GO:0045628)3.28606432
75histone H3-K9 demethylation (GO:0033169)3.26733857
76ether metabolic process (GO:0018904)3.24626591
77protein-DNA complex disassembly (GO:0032986)3.22494643
78nucleosome disassembly (GO:0006337)3.22494643
79cellular response to pH (GO:0071467)3.16766673
80polyamine biosynthetic process (GO:0006596)3.10326276
81homeostasis of number of cells within a tissue (GO:0048873)3.07630745
82multicellular organismal development (GO:0007275)2.96238109
83negative regulation of histone methylation (GO:0031061)2.95886510
84mesenchymal cell differentiation involved in kidney development (GO:0072161)2.90077254
85mesenchymal cell differentiation involved in renal system development (GO:2001012)2.90077254
86DNA conformation change (GO:0071103)2.88661975
87membrane protein intracellular domain proteolysis (GO:0031293)2.87747158
88protein depolymerization (GO:0051261)2.86765347
89cell recognition (GO:0008037)2.86692916
90cranial nerve morphogenesis (GO:0021602)2.85452338
91detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.83691788
92regulation of ARF GTPase activity (GO:0032312)2.83231309
93NAD biosynthetic process (GO:0009435)2.81703057
94cell differentiation involved in metanephros development (GO:0072202)2.79870156
95male meiosis I (GO:0007141)2.78882634
96receptor recycling (GO:0001881)2.78873435
97regulation of phosphoprotein phosphatase activity (GO:0043666)2.77183864
98acrosome reaction (GO:0007340)11.7089316
99fusion of sperm to egg plasma membrane (GO:0007342)11.5472514
100sperm motility (GO:0030317)11.5223275

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.91354624
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.55513010
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.13143946
4TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36918259
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.36918259
6EZH2_22144423_ChIP-Seq_EOC_Human2.23792507
7IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.23702826
8CBP_20019798_ChIP-Seq_JUKART_Human2.23702826
9VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.18018566
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16333015
11DROSHA_22980978_ChIP-Seq_HELA_Human2.10087984
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04282068
13RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.93568029
14* ERA_21632823_ChIP-Seq_H3396_Human1.92198100
15* ELF1_20517297_ChIP-Seq_JURKAT_Human1.91933059
16WDR5_24793694_ChIP-Seq_LNCAP_Human1.91794471
17RAC3_21632823_ChIP-Seq_H3396_Human1.87493152
18NANOG_20526341_ChIP-Seq_ESCs_Human1.86543988
19EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.85360140
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84473071
21* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.80677833
22CTCF_27219007_Chip-Seq_Bcells_Human1.78348691
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77074608
24ER_23166858_ChIP-Seq_MCF-7_Human1.70790813
25* BCL6_27268052_Chip-Seq_Bcells_Human1.66885713
26FUS_26573619_Chip-Seq_HEK293_Human1.66861019
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64871404
28* SMC4_20622854_ChIP-Seq_HELA_Human1.61836113
29TAF2_19829295_ChIP-Seq_ESCs_Human1.60760177
30BCOR_27268052_Chip-Seq_Bcells_Human1.60340438
31PHF8_20622854_ChIP-Seq_HELA_Human1.59932506
32* E2F1_20622854_ChIP-Seq_HELA_Human1.58623655
33CTCF_20526341_ChIP-Seq_ESCs_Human1.56488999
34OCT4_20526341_ChIP-Seq_ESCs_Human1.53879501
35PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.52176568
36* P68_20966046_ChIP-Seq_HELA_Human1.51983790
37ARNT_22903824_ChIP-Seq_MCF-7_Human1.50970494
38YY1_22570637_ChIP-Seq_MALME-3M_Human1.50215819
39* MYC_19829295_ChIP-Seq_ESCs_Human1.49564340
40ETV2_25802403_ChIP-Seq_MESCs_Mouse1.48633588
41AUTS2_25519132_ChIP-Seq_293T-REX_Human1.48398965
42TDRD3_21172665_ChIP-Seq_MCF-7_Human1.48259153
43TP63_22573176_ChIP-Seq_HFKS_Human1.46269040
44AR_21572438_ChIP-Seq_LNCaP_Human1.45170555
45P300_27268052_Chip-Seq_Bcells_Human1.44281673
46SMAD4_21741376_ChIP-Seq_EPCs_Human1.43683234
47AR_25329375_ChIP-Seq_VCAP_Human1.40665625
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37512781
49LXR_22292898_ChIP-Seq_THP-1_Human1.37352700
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36442067
51SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.35860648
52ERG_20517297_ChIP-Seq_VCAP_Human1.35644275
53SMAD3_21741376_ChIP-Seq_ESCs_Human1.35547143
54ZNF274_21170338_ChIP-Seq_K562_Hela1.34272428
55HNFA_21074721_ChIP-Seq_CACO-2_Human1.32337366
56RBPJ_21746931_ChIP-Seq_IB4_Human1.30771783
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.30563265
58CEBPB_22108803_ChIP-Seq_LS180_Human1.30244233
59CBX2_22325352_ChIP-Seq_293T-Rex_Human1.29419053
60SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28636733
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28523284
62CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.27636322
63P53_21459846_ChIP-Seq_SAOS-2_Human1.27616873
64ETV1_20927104_ChIP-Seq_GIST48_Human1.27404980
65TP53_18474530_ChIP-ChIP_U2OS_Human1.27391981
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26564110
67P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.26092622
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25896034
69TAF15_26573619_Chip-Seq_HEK293_Human1.25556545
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.24387725
71KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.23384085
72SOX2_22085726_ChIP-Seq_NPCs_Mouse1.22208263
73NFYB_21822215_ChIP-Seq_K562_Human1.18839167
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17269356
75* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16339297
76P300_19829295_ChIP-Seq_ESCs_Human1.15440009
77TBL1_22424771_ChIP-Seq_293T_Human1.15299495
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14593672
79SA1_27219007_Chip-Seq_Bcells_Human1.14352855
80RUNX1_26923725_Chip-Seq_HPCs_Mouse1.13043751
81ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12091178
82PHF8_20622853_ChIP-Seq_HELA_Human1.10491084
83PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08360238
84TCF4_18268006_ChIP-ChIP_LS174T_Human1.08014611
85GATA6_21074721_ChIP-Seq_CACO-2_Human1.07423588
86SMAD4_21741376_ChIP-Seq_HESCs_Human1.07160261
87EZH2_27294783_Chip-Seq_ESCs_Mouse1.06333958
88TP63_19390658_ChIP-ChIP_HaCaT_Human1.05647259
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05409155
90* SMRT_27268052_Chip-Seq_Bcells_Human1.04893102
91NFYA_21822215_ChIP-Seq_K562_Human1.03900999
92* RUNX2_22187159_ChIP-Seq_PCA_Human1.02161358
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02024051
94SOX2_19829295_ChIP-Seq_ESCs_Human1.01734245
95NANOG_19829295_ChIP-Seq_ESCs_Human1.01734245
96KLF5_25053715_ChIP-Seq_YYC3_Human1.00956819
97HOXB7_26014856_ChIP-Seq_BT474_Human1.00949078
98FOXH1_21741376_ChIP-Seq_ESCs_Human0.98892758
99OCT1_27270436_Chip-Seq_PROSTATE_Human0.97482998
100PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.97218764

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.55788685
2MP0003878_abnormal_ear_physiology5.55788685
3MP0005670_abnormal_white_adipose4.60341846
4MP0003698_abnormal_male_reproductive4.31136674
5MP0001348_abnormal_lacrimal_gland4.29058578
6MP0001929_abnormal_gametogenesis3.70429137
7MP0000678_abnormal_parathyroid_gland2.66210581
8MP0005379_endocrine/exocrine_gland_phen2.41408704
9MP0002161_abnormal_fertility/fecundity2.39359797
10MP0002822_catalepsy2.18810262
11MP0002132_abnormal_respiratory_system2.18670027
12MP0003718_maternal_effect2.17852534
13MP0005410_abnormal_fertilization11.9689346
14MP0003646_muscle_fatigue1.70655969
15MP0002210_abnormal_sex_determination1.67744928
16MP0002249_abnormal_larynx_morphology1.62038633
17MP0001485_abnormal_pinna_reflex1.59394171
18MP0002234_abnormal_pharynx_morphology1.56256410
19MP0009053_abnormal_anal_canal1.53474558
20MP0005451_abnormal_body_composition1.52724231
21MP0001486_abnormal_startle_reflex1.52343893
22MP0005423_abnormal_somatic_nervous1.47347773
23MP0003011_delayed_dark_adaptation1.47136395
24MP0002282_abnormal_trachea_morphology1.46431923
25MP0001145_abnormal_male_reproductive1.31977897
26MP0002735_abnormal_chemical_nociception1.29590459
27MP0000653_abnormal_sex_gland1.28066523
28MP0004859_abnormal_synaptic_plasticity1.24933001
29MP0004742_abnormal_vestibular_system1.22979845
30MP0000534_abnormal_ureter_morphology1.22547027
31MP0001968_abnormal_touch/_nociception1.19830960
32MP0002138_abnormal_hepatobiliary_system1.18407343
33MP0005310_abnormal_salivary_gland1.18404371
34MP0003879_abnormal_hair_cell1.18226637
35MP0001765_abnormal_ion_homeostasis1.13594368
36MP0004510_myositis1.12893877
37MP0002127_abnormal_cardiovascular_syste1.10409470
38MP0001963_abnormal_hearing_physiology1.09484175
39MP0005248_abnormal_Harderian_gland1.06898890
40MP0000026_abnormal_inner_ear1.01601896
41MP0005395_other_phenotype1.01562878
42MP0000955_abnormal_spinal_cord0.86149378
43MP0000681_abnormal_thyroid_gland0.85044332
44MP0005666_abnormal_adipose_tissue0.84055483
45MP0002229_neurodegeneration0.81268377
46MP0001905_abnormal_dopamine_level0.81025222
47MP0008569_lethality_at_weaning0.79659638
48MP0000049_abnormal_middle_ear0.77659056
49MP0002733_abnormal_thermal_nociception0.77199458
50MP0005551_abnormal_eye_electrophysiolog0.77054612
51MP0008877_abnormal_DNA_methylation0.76806355
52MP0005367_renal/urinary_system_phenotyp0.73317099
53MP0000516_abnormal_urinary_system0.73317099
54MP0002067_abnormal_sensory_capabilities0.72936217
55MP0005167_abnormal_blood-brain_barrier0.71800662
56MP0009115_abnormal_fat_cell0.71368835
57MP0005375_adipose_tissue_phenotype0.69225108
58MP0001666_abnormal_nutrient_absorption0.69045718
59MP0004085_abnormal_heartbeat0.68372667
60MP0002557_abnormal_social/conspecific_i0.67414991
61MP0005535_abnormal_body_temperature0.61542737
62MP0002572_abnormal_emotion/affect_behav0.60650999
63MP0005253_abnormal_eye_physiology0.60036282
64MP0005636_abnormal_mineral_homeostasis0.57387705
65MP0001440_abnormal_grooming_behavior0.57135189
66MP0009745_abnormal_behavioral_response0.57004323
67MP0002653_abnormal_ependyma_morphology0.56587993
68MP0004233_abnormal_muscle_weight0.56319510
69MP0000003_abnormal_adipose_tissue0.55588495
70MP0004484_altered_response_of0.53908106
71MP0001970_abnormal_pain_threshold0.52327860
72MP0001879_abnormal_lymphatic_vessel0.52306149
73MP0003119_abnormal_digestive_system0.51427649
74MP0002734_abnormal_mechanical_nocicepti0.50857067
75MP0009697_abnormal_copulation0.50763897
76MP0005623_abnormal_meninges_morphology0.45814981
77MP0002272_abnormal_nervous_system0.45251283
78MP0005083_abnormal_biliary_tract0.44261284
79MP0000470_abnormal_stomach_morphology0.43206591
80MP0003077_abnormal_cell_cycle0.43118089
81MP0006292_abnormal_olfactory_placode0.41985188
82MP0002928_abnormal_bile_duct0.41158417
83MP0003137_abnormal_impulse_conducting0.39287130
84MP0000566_synostosis0.39211091
85MP0003699_abnormal_female_reproductive0.38940137
86MP0001545_abnormal_hematopoietic_system0.38897128
87MP0005397_hematopoietic_system_phenotyp0.38897128
88MP0001501_abnormal_sleep_pattern0.37420805
89MP0000249_abnormal_blood_vessel0.37163571
90MP0003936_abnormal_reproductive_system0.37036822
91MP0003635_abnormal_synaptic_transmissio0.36733464
92MP0004036_abnormal_muscle_relaxation0.36694029
93MP0009764_decreased_sensitivity_to0.35414915
94MP0008995_early_reproductive_senescence0.34494220
95MP0001270_distended_abdomen0.33242940
96MP0008961_abnormal_basal_metabolism0.32358011
97MP0003880_abnormal_central_pattern0.32207461
98MP0003091_abnormal_cell_migration0.31640186
99MP0005391_vision/eye_phenotype0.31525646
100MP0003631_nervous_system_phenotype0.31314535

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.21115917
2Asymmetric septal hypertrophy (HP:0001670)6.12196900
3Absent/shortened dynein arms (HP:0200106)5.94123419
4Dynein arm defect of respiratory motile cilia (HP:0012255)5.94123419
5Attenuation of retinal blood vessels (HP:0007843)5.18796550
6Bony spicule pigmentary retinopathy (HP:0007737)5.17103298
7Bell-shaped thorax (HP:0001591)4.82007690
8Abnormal ciliary motility (HP:0012262)4.59478670
9Male infertility (HP:0003251)4.54110169
10Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.51356535
11Resting tremor (HP:0002322)4.48425075
12Abnormal respiratory motile cilium physiology (HP:0012261)4.45746362
13Tubulointerstitial nephritis (HP:0001970)4.35770805
14Abnormal respiratory epithelium morphology (HP:0012253)4.34583668
15Abnormal respiratory motile cilium morphology (HP:0005938)4.34583668
16Hypoplastic ischia (HP:0003175)4.29094314
17Hyperkalemia (HP:0002153)4.27501426
18Infertility (HP:0000789)4.17993797
19Potter facies (HP:0002009)4.15186079
20Facial shape deformation (HP:0011334)4.15186079
21Chronic hepatic failure (HP:0100626)4.06074366
22Enlarged epiphyses (HP:0010580)4.01150952
23Abnormal rod and cone electroretinograms (HP:0008323)3.90869130
24Nasal polyposis (HP:0100582)3.85908483
25Abnormality of the ischium (HP:0003174)3.81183743
26Impulsivity (HP:0100710)3.80327376
27Aplasia/Hypoplasia of the earlobes (HP:0009906)3.77601559
28Abnormality of macular pigmentation (HP:0008002)3.77445118
29Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.66112436
30Cone-rod dystrophy (HP:0000548)3.37408392
31Abnormal spermatogenesis (HP:0008669)3.36452999
32Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.26561237
33Hypoplasia of the thymus (HP:0000778)3.15285903
34Azoospermia (HP:0000027)3.13178092
35Abnormality of the nasal mucosa (HP:0000433)3.11325786
36Postural instability (HP:0002172)3.04287587
37Nephronophthisis (HP:0000090)2.94255908
38Abnormal urine output (HP:0012590)2.87621191
39Abnormality of the costochondral junction (HP:0000919)2.76312760
40Epiphyseal dysplasia (HP:0002656)2.71626872
41Progressive cerebellar ataxia (HP:0002073)2.63223470
42Congenital malformation of the right heart (HP:0011723)2.60659270
43Double outlet right ventricle (HP:0001719)2.60659270
44Amelogenesis imperfecta (HP:0000705)2.59621625
45Unilateral renal agenesis (HP:0000122)2.57458383
46Rhinitis (HP:0012384)2.57329056
47Generalized aminoaciduria (HP:0002909)2.56036807
48Abnormality of the aortic arch (HP:0012303)2.53256600
49Abnormality of potassium homeostasis (HP:0011042)2.51853300
50Progressive sensorineural hearing impairment (HP:0000408)2.51491897
51Stage 5 chronic kidney disease (HP:0003774)2.50693191
52Renal dysplasia (HP:0000110)2.48717729
53Abnormality of dental color (HP:0011073)2.48016060
54Abnormality of renal excretion (HP:0011036)2.47771043
55Abnormality of the renal medulla (HP:0100957)2.46614771
56Hypoalphalipoproteinemia (HP:0003233)2.46537294
57Portal hypertension (HP:0001409)2.45099903
58Truncal obesity (HP:0001956)2.35543170
59Hypophosphatemic rickets (HP:0004912)2.35333517
60Polydipsia (HP:0001959)2.35023109
61Abnormal drinking behavior (HP:0030082)2.35023109
62Tubulointerstitial abnormality (HP:0001969)2.30740325
63Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.28106609
64Absent epiphyses (HP:0010577)2.28106609
65Widely patent fontanelles and sutures (HP:0004492)2.26349675
66Polyuria (HP:0000103)2.25604020
67Abnormality of the hepatic vasculature (HP:0006707)2.22708847
68Aplasia/Hypoplasia of the sacrum (HP:0008517)2.22647512
69Abnormality of the parathyroid morphology (HP:0011766)2.22365899
70Intellectual disability, moderate (HP:0002342)2.18865562
71Spastic paraparesis (HP:0002313)2.15380379
72Ventricular tachycardia (HP:0004756)2.15219860
73Abnormality of the pubic bones (HP:0003172)2.13575864
74Hyponatremia (HP:0002902)2.08906285
75Mixed hearing impairment (HP:0000410)2.05387335
76Renovascular hypertension (HP:0100817)2.05262806
77Abnormality of the epiphysis of the femoral head (HP:0010574)2.02980380
78Flattened epiphyses (HP:0003071)1.96839226
79Bronchiectasis (HP:0002110)1.96416741
80Insulin-resistant diabetes mellitus (HP:0000831)1.93821141
81Osteomalacia (HP:0002749)1.92970776
82Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.90825036
83Abnormality of femoral epiphyses (HP:0006499)1.90825036
84Decreased central vision (HP:0007663)1.88568920
85Short ribs (HP:0000773)1.88239979
86Menstrual irregularities (HP:0000858)1.87539028
87Chronic bronchitis (HP:0004469)1.86988521
88Occipital encephalocele (HP:0002085)1.84865177
89Transposition of the great arteries (HP:0001669)1.82540732
90Abnormal connection of the cardiac segments (HP:0011545)1.82540732
91Abnormal ventriculo-arterial connection (HP:0011563)1.82540732
92Tubular atrophy (HP:0000092)1.82292030
93Protuberant abdomen (HP:0001538)1.80933768
94Sensory axonal neuropathy (HP:0003390)1.79663430
95Abnormality of the femoral head (HP:0003368)1.79256295
96Vertebral clefting (HP:0008428)1.76969644
97Recurrent corneal erosions (HP:0000495)1.75815414
98Recurrent pneumonia (HP:0006532)1.73867955
99Anterior segment dysgenesis (HP:0007700)1.69053585
100Bradycardia (HP:0001662)1.68497753

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK49.01335625
2TESK16.15206360
3DDR25.37416141
4INSRR3.44700747
5PLK23.37969730
6BRD43.03512084
7STK382.89154421
8PNCK2.73582481
9MAP4K22.48386405
10MAPK152.34248152
11CAMK1G2.29847117
12MST1R2.17352205
13STK38L2.06013660
14PRKD31.91699691
15PIK3CG1.69897656
16PDPK11.63689732
17WNK11.62734459
18PDK11.51840927
19CDK71.48681277
20CDK121.43574362
21PTK2B1.24687242
22DYRK1B1.18353214
23NEK61.13813881
24MAP3K90.99573172
25CAMK1D0.96936634
26KSR20.92029334
27LATS20.86924204
28SIK20.84793430
29UHMK10.82627781
30RPS6KA20.80633429
31AKT30.79251827
32PRKG20.78587196
33PRKG10.73911617
34BRAF0.72582075
35TYRO30.65699869
36MAP3K110.64864019
37PRKAA20.64519173
38WNK40.64436506
39LATS10.63992447
40RPS6KA10.62874358
41TESK20.59283235
42MAP2K20.56473053
43MAP3K20.52860857
44CAMK10.49099957
45ROCK10.48110049
46MAP3K80.47441011
47RPS6KL10.47298676
48RPS6KC10.47298676
49JAK30.47262778
50MUSK0.47003471
51CDK20.46241471
52GSK3B0.44364144
53CDK190.44322455
54RPS6KA60.43254436
55STK390.43063561
56MAPK10.41124031
57MET0.39861469
58CDK10.39630267
59CDK30.39281116
60MTOR0.38468015
61ARAF0.35482613
62SGK4940.34606837
63SGK2230.34606837
64MARK10.34376157
65PRKCG0.33803702
66MAPK80.31897323
67OXSR10.31752978
68MAPK110.30512931
69PRKCZ0.29569998
70CHEK10.29324015
71RIPK40.27913334
72CAMK40.27556750
73BMPR1B0.27137385
74PRKCB0.26988015
75NTRK30.25581984
76SGK10.25459002
77MAPK140.24559434
78MAP3K10.24126216
79CDK40.23530134
80TNIK0.22848803
81MAP3K40.22572798
82ADRBK20.22302231
83BRSK10.21239200
84TIE10.20929030
85FER0.20114756
86MAPK100.19552437
87NEK20.19113854
88MARK20.17886570
89AKT10.17743199
90PKN10.17705228
91FRK0.17158175
92RIPK10.14520625
93DYRK30.11773117
94PRKCE0.11556414
95PRKACB0.10691301
96PRKACA0.09393396
97PRKAA10.08782802
98IKBKB0.08591372
99SGK20.07977530
100CDK11A0.07453281

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.02885370
2Fatty acid biosynthesis_Homo sapiens_hsa000615.53452354
3Olfactory transduction_Homo sapiens_hsa047404.10702377
4Butanoate metabolism_Homo sapiens_hsa006502.41296628
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.37163702
6Glycerophospholipid metabolism_Homo sapiens_hsa005642.08835004
7Type I diabetes mellitus_Homo sapiens_hsa049401.89296835
8Allograft rejection_Homo sapiens_hsa053301.88610966
9Dorso-ventral axis formation_Homo sapiens_hsa043201.87950351
10Taste transduction_Homo sapiens_hsa047421.84257360
11Autoimmune thyroid disease_Homo sapiens_hsa053201.84116386
12Graft-versus-host disease_Homo sapiens_hsa053321.75505877
13Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.55154742
14Phenylalanine metabolism_Homo sapiens_hsa003601.54458241
15Type II diabetes mellitus_Homo sapiens_hsa049301.52744998
16Fatty acid degradation_Homo sapiens_hsa000711.49423870
17Antigen processing and presentation_Homo sapiens_hsa046121.47672683
18RNA transport_Homo sapiens_hsa030131.39748127
19Protein digestion and absorption_Homo sapiens_hsa049741.34724518
20Viral myocarditis_Homo sapiens_hsa054161.33031704
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.31182346
22Arginine and proline metabolism_Homo sapiens_hsa003301.28901010
23Synaptic vesicle cycle_Homo sapiens_hsa047211.26086562
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21108640
25Fatty acid metabolism_Homo sapiens_hsa012121.20455706
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.17080112
27Adipocytokine signaling pathway_Homo sapiens_hsa049201.16594029
28Phototransduction_Homo sapiens_hsa047441.15830396
29Selenocompound metabolism_Homo sapiens_hsa004501.14026512
30Salivary secretion_Homo sapiens_hsa049701.11865306
31ABC transporters_Homo sapiens_hsa020101.09276789
32Endocytosis_Homo sapiens_hsa041441.09080057
33Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.03311748
34Inositol phosphate metabolism_Homo sapiens_hsa005621.01624415
35Arginine biosynthesis_Homo sapiens_hsa002201.00649867
36Oocyte meiosis_Homo sapiens_hsa041141.00454561
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95194255
38Calcium signaling pathway_Homo sapiens_hsa040200.92626421
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92558124
40Renin-angiotensin system_Homo sapiens_hsa046140.89014336
41Primary bile acid biosynthesis_Homo sapiens_hsa001200.87839073
42Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84275084
43Morphine addiction_Homo sapiens_hsa050320.84238636
44cAMP signaling pathway_Homo sapiens_hsa040240.83416355
45Fat digestion and absorption_Homo sapiens_hsa049750.83143355
46Cardiac muscle contraction_Homo sapiens_hsa042600.82768603
47Circadian entrainment_Homo sapiens_hsa047130.82439001
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81136340
49Glycerolipid metabolism_Homo sapiens_hsa005610.76645076
50PPAR signaling pathway_Homo sapiens_hsa033200.74669334
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.74403080
52Retinol metabolism_Homo sapiens_hsa008300.73176289
53Tyrosine metabolism_Homo sapiens_hsa003500.73055108
54Influenza A_Homo sapiens_hsa051640.71499226
55Bile secretion_Homo sapiens_hsa049760.71226073
56Nicotine addiction_Homo sapiens_hsa050330.71127727
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70241571
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68854756
59Estrogen signaling pathway_Homo sapiens_hsa049150.65961844
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65734268
61Hedgehog signaling pathway_Homo sapiens_hsa043400.65362779
62Gastric acid secretion_Homo sapiens_hsa049710.64807504
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64621052
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58702811
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57188565
66Glutamatergic synapse_Homo sapiens_hsa047240.56958672
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55773855
68Renin secretion_Homo sapiens_hsa049240.54722261
69Tight junction_Homo sapiens_hsa045300.51451706
70Acute myeloid leukemia_Homo sapiens_hsa052210.49091740
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.48209746
72Purine metabolism_Homo sapiens_hsa002300.47815338
73Basal transcription factors_Homo sapiens_hsa030220.47146906
74VEGF signaling pathway_Homo sapiens_hsa043700.46604906
75Insulin secretion_Homo sapiens_hsa049110.46338169
76Cholinergic synapse_Homo sapiens_hsa047250.45647624
77Serotonergic synapse_Homo sapiens_hsa047260.44781780
78MAPK signaling pathway_Homo sapiens_hsa040100.44278686
79ECM-receptor interaction_Homo sapiens_hsa045120.43351562
80Pancreatic secretion_Homo sapiens_hsa049720.37603473
81Oxytocin signaling pathway_Homo sapiens_hsa049210.30835077
82GABAergic synapse_Homo sapiens_hsa047270.30550120
83Nitrogen metabolism_Homo sapiens_hsa009100.29050525
84Prolactin signaling pathway_Homo sapiens_hsa049170.29016912
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28501391
86Fanconi anemia pathway_Homo sapiens_hsa034600.28388219
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.28110767
88Linoleic acid metabolism_Homo sapiens_hsa005910.26841100
89mRNA surveillance pathway_Homo sapiens_hsa030150.25471175
90Viral carcinogenesis_Homo sapiens_hsa052030.25255621
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23587866
92Long-term potentiation_Homo sapiens_hsa047200.23009371
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22935534
94Huntingtons disease_Homo sapiens_hsa050160.20559133
95Herpes simplex infection_Homo sapiens_hsa051680.19167690
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.18371173
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.15448949
98Chemical carcinogenesis_Homo sapiens_hsa052040.13772432
99Adherens junction_Homo sapiens_hsa045200.13630223
100Choline metabolism in cancer_Homo sapiens_hsa052310.13114422

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