GOLGA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein is a coiled-coil membrane protein that has been postulated to play a role in vesicle tethering and docking. Translocations involving this gene and the ret proto-oncogene have been found in tumor tissues; the chimeric sequences have been designated RET-II and PTC5. A pseudogene of this gene is located on the short arm of chromosome 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.67689494
2Golgi transport vesicle coating (GO:0048200)6.67689494
3cell adhesion mediated by integrin (GO:0033627)4.61357771
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.51240483
5COPII vesicle coating (GO:0048208)4.48883841
6protein retention in ER lumen (GO:0006621)3.94998488
7activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.83084386
8skin morphogenesis (GO:0043589)3.81963748
9retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.78979192
10positive regulation of nuclease activity (GO:0032075)3.73103475
11protein localization to endosome (GO:0036010)3.61564295
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.57352063
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.57352063
14ER overload response (GO:0006983)3.53266626
15negative regulation of protein localization to plasma membrane (GO:1903077)3.50749378
16regulation of nuclease activity (GO:0032069)3.50733254
17peptidyl-proline hydroxylation (GO:0019511)3.44906555
18desmosome organization (GO:0002934)3.38895418
19endoplasmic reticulum unfolded protein response (GO:0030968)3.38373812
20signal peptide processing (GO:0006465)3.37635184
21hemidesmosome assembly (GO:0031581)3.30900190
22cellular response to unfolded protein (GO:0034620)3.28332951
23nucleotide-sugar biosynthetic process (GO:0009226)3.25748407
24protein hydroxylation (GO:0018126)3.25501851
25protein maturation by protein folding (GO:0022417)3.20088697
26antigen processing and presentation of endogenous antigen (GO:0019883)3.17424625
27cellular response to topologically incorrect protein (GO:0035967)3.12949604
28ER-nucleus signaling pathway (GO:0006984)3.12353419
29membrane budding (GO:0006900)3.08673014
30vesicle coating (GO:0006901)3.00743206
31folic acid-containing compound biosynthetic process (GO:0009396)2.99485264
32regulation of transforming growth factor beta2 production (GO:0032909)2.96882862
33negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.95702416
34membrane raft organization (GO:0031579)2.93654875
35regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.88748305
36pyrimidine-containing compound salvage (GO:0008655)2.87473782
37pyrimidine nucleoside salvage (GO:0043097)2.87473782
38valine metabolic process (GO:0006573)2.86434211
39cellular copper ion homeostasis (GO:0006878)2.85165753
404-hydroxyproline metabolic process (GO:0019471)2.80113191
41pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.79920779
42UMP metabolic process (GO:0046049)2.79920779
43pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.79920779
44UMP biosynthetic process (GO:0006222)2.79920779
45peptide catabolic process (GO:0043171)2.79703518
46monoubiquitinated protein deubiquitination (GO:0035520)2.78980689
47endodermal cell differentiation (GO:0035987)2.78694505
48ER to Golgi vesicle-mediated transport (GO:0006888)2.78651966
49collagen fibril organization (GO:0030199)2.78368479
50UDP-N-acetylglucosamine metabolic process (GO:0006047)2.78245676
51hyaluronan catabolic process (GO:0030214)2.78186657
52hormone catabolic process (GO:0042447)2.77378342
53negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.74289342
54retina vasculature morphogenesis in camera-type eye (GO:0061299)2.73487828
55type B pancreatic cell proliferation (GO:0044342)2.72353654
56nucleoside salvage (GO:0043174)2.71850463
57very-low-density lipoprotein particle assembly (GO:0034379)2.71029493
58antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.70118279
59basement membrane organization (GO:0071711)2.70075225
60keratan sulfate catabolic process (GO:0042340)2.68594413
61nucleotide salvage (GO:0043173)2.68574576
62positive regulation of histone deacetylation (GO:0031065)2.68164511
63regulation of RIG-I signaling pathway (GO:0039535)2.66726564
64viral entry into host cell (GO:0046718)2.66077256
65positive regulation of endothelial cell apoptotic process (GO:2000353)2.65447127
66regulation of transforming growth factor beta1 production (GO:0032908)2.65401127
67bundle of His cell to Purkinje myocyte communication (GO:0086069)2.63841731
68positive regulation of p38MAPK cascade (GO:1900745)2.63611885
69iron ion import (GO:0097286)2.63161446
70response to endoplasmic reticulum stress (GO:0034976)2.60975974
71growth hormone receptor signaling pathway (GO:0060396)2.60398077
72epithelial cell-cell adhesion (GO:0090136)2.60082932
73cell-substrate junction assembly (GO:0007044)2.59241920
74wound healing, spreading of epidermal cells (GO:0035313)2.56775276
75response to unfolded protein (GO:0006986)2.56493073
76hypotonic response (GO:0006971)2.56337724
77embryonic process involved in female pregnancy (GO:0060136)2.56167672
78regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.54579942
79regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.54165122
80L-serine transport (GO:0015825)2.53978164
81barbed-end actin filament capping (GO:0051016)2.53882733
82regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.52738237
83endocrine pancreas development (GO:0031018)2.51365828
84regulation of type B pancreatic cell apoptotic process (GO:2000674)2.50992766
85regulation of metalloenzyme activity (GO:0048552)2.49121546
86apoptotic cell clearance (GO:0043277)2.49010253
87type B pancreatic cell development (GO:0003323)2.48655504
88protein-lipid complex assembly (GO:0065005)2.47783301
89response to topologically incorrect protein (GO:0035966)2.47296451
90branching involved in mammary gland duct morphogenesis (GO:0060444)2.46950062
91regulation of protein localization to plasma membrane (GO:1903076)2.46676315
92negative regulation of anoikis (GO:2000811)2.46536024
93chondrocyte development (GO:0002063)2.45508131
94localization within membrane (GO:0051668)2.45225560
95nuclear pore complex assembly (GO:0051292)2.45152728
96membrane protein ectodomain proteolysis (GO:0006509)2.44832128
97synaptonemal complex assembly (GO:0007130)2.44047724
98tricarboxylic acid metabolic process (GO:0072350)2.43951597
99mammary gland epithelial cell proliferation (GO:0033598)2.43564131
100regulation of RNA export from nucleus (GO:0046831)2.43014223
101regulation of cardioblast differentiation (GO:0051890)2.42845330
102ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.42833038
103protein N-linked glycosylation via asparagine (GO:0018279)2.41393259
104negative regulation of fatty acid transport (GO:2000192)2.41189387
105negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.39486439
106histone H2A monoubiquitination (GO:0035518)2.39187232
107peptidyl-asparagine modification (GO:0018196)2.38591292
108piRNA metabolic process (GO:0034587)2.38522678
109nucleotide-sugar metabolic process (GO:0009225)2.38466309
110positive regulation of extracellular matrix organization (GO:1903055)2.37494193
111positive regulation of hormone biosynthetic process (GO:0046886)2.37152184
112protein N-linked glycosylation (GO:0006487)2.36845608
113erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.36246946
114L-phenylalanine catabolic process (GO:0006559)2.36246946
115positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.34656873
116pinocytosis (GO:0006907)2.34593775
117histone H3-K9 demethylation (GO:0033169)2.34473609
118plasma lipoprotein particle assembly (GO:0034377)2.33793178
119peptidyl-glutamic acid carboxylation (GO:0017187)2.32894101
120protein carboxylation (GO:0018214)2.32894101
121regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.32170830
122negative regulation of fatty acid biosynthetic process (GO:0045717)2.31808989
123erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.30810812
124L-phenylalanine metabolic process (GO:0006558)2.30810812
125pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.30729153
126paraxial mesoderm development (GO:0048339)2.30321215
127antigen processing and presentation via MHC class Ib (GO:0002475)2.30090070
128chaperone mediated protein folding requiring cofactor (GO:0051085)2.29463937
129fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.29184836
130cellular zinc ion homeostasis (GO:0006882)2.27324079
131embryo implantation (GO:0007566)2.26543457
132serine transport (GO:0032329)2.26343805
133regulation of endothelial cell apoptotic process (GO:2000351)2.25931364
134negative regulation of fibrinolysis (GO:0051918)2.25777138
135peptidyl-lysine dimethylation (GO:0018027)2.25106087
136lysine catabolic process (GO:0006554)2.25103433
137lysine metabolic process (GO:0006553)2.25103433
138surfactant homeostasis (GO:0043129)2.23513199
139synaptonemal complex organization (GO:0070193)2.22608134
140positive regulation of gamma-delta T cell activation (GO:0046645)2.21036634
141JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.20835461
142positive regulation of protein deacetylation (GO:0090312)2.20731731
143regulation of hexokinase activity (GO:1903299)2.20111049
144regulation of glucokinase activity (GO:0033131)2.20111049
145cysteine metabolic process (GO:0006534)2.18604024
146cellular response to growth hormone stimulus (GO:0071378)2.15678144
147mitotic nuclear envelope disassembly (GO:0007077)2.14665406
148regulation of chromatin binding (GO:0035561)2.14137548
149intestinal epithelial cell development (GO:0060576)2.13613413
150* Golgi organization (GO:0007030)2.12464882
151regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.09046762
152positive regulation of protein import into nucleus, translocation (GO:0033160)2.08904884
153regulation of cholesterol homeostasis (GO:2000188)2.08264142
154exocrine pancreas development (GO:0031017)2.08204220
155nuclear envelope disassembly (GO:0051081)2.07448428
156membrane disassembly (GO:0030397)2.07448428
157intestinal cholesterol absorption (GO:0030299)2.05944427
158pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.05537960
159sequestering of metal ion (GO:0051238)2.03804147
160sulfur amino acid catabolic process (GO:0000098)2.03547200
161mitotic sister chromatid cohesion (GO:0007064)2.03241938
162macroautophagy (GO:0016236)2.02723106
163gene silencing by RNA (GO:0031047)2.02330753
164glandular epithelial cell development (GO:0002068)2.00971750
1652-oxoglutarate metabolic process (GO:0006103)1.99440032
166pteridine-containing compound biosynthetic process (GO:0042559)1.99334087
167xenobiotic catabolic process (GO:0042178)1.97735118
168urea cycle (GO:0000050)1.96905642
169urea metabolic process (GO:0019627)1.96905642
170alpha-linolenic acid metabolic process (GO:0036109)1.96755473
171nuclear pore organization (GO:0006999)1.95481180
172negative regulation of lipid transport (GO:0032369)1.95346678
173male meiosis (GO:0007140)1.95176835

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.91887083
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.76768997
3SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.37439968
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.33157784
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.31254893
6E2F7_22180533_ChIP-Seq_HELA_Human3.11265758
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.96032609
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.91483012
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.76984306
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.57907620
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.48333719
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.42150127
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.39611199
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.26770825
15SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.21966107
16SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.21966107
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.20833256
18MYC_22102868_ChIP-Seq_BL_Human2.16315718
19WT1_19549856_ChIP-ChIP_CCG9911_Human2.12696960
20CLOCK_20551151_ChIP-Seq_293T_Human2.11498989
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.08257703
22LXR_22158963_ChIP-Seq_LIVER_Mouse2.08070950
23ZNF217_24962896_ChIP-Seq_MCF-7_Human2.06642207
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.97741171
25MYB_21317192_ChIP-Seq_ERMYB_Mouse1.96579150
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.93125389
27BRD4_25478319_ChIP-Seq_HGPS_Human1.84356320
28PPAR_26484153_Chip-Seq_NCI-H1993_Human1.82314442
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76471000
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.74053869
31GATA1_22025678_ChIP-Seq_K562_Human1.72830327
32SOX2_20726797_ChIP-Seq_SW620_Human1.70125391
33EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.69550335
34FOXM1_23109430_ChIP-Seq_U2OS_Human1.69416189
35EGR1_23403033_ChIP-Seq_LIVER_Mouse1.67448024
36CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.60549639
37CJUN_26792858_Chip-Seq_BT549_Human1.59511895
38ZNF263_19887448_ChIP-Seq_K562_Human1.59378153
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57849860
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.56978986
41KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.56626950
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.55826378
43RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.55195882
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54109750
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.52390490
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.51351213
47MYB_26560356_Chip-Seq_TH2_Human1.49123819
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.48794550
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47619271
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46758173
51MYB_26560356_Chip-Seq_TH1_Human1.46650418
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46640751
53EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46223318
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.45744461
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.45206461
56TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.44222664
57MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.44037150
58SOX9_24532713_ChIP-Seq_HFSC_Mouse1.40482853
59AR_21909140_ChIP-Seq_LNCAP_Human1.39398808
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39043894
61IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.38145465
62GATA3_24758297_ChIP-Seq_MCF-7_Human1.34528769
63* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.34015125
64IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33466437
65CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.33396179
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32985816
67NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32985816
68KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32684564
69SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.30711275
70SOX2_27498859_Chip-Seq_STOMACH_Mouse1.29688053
71SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29447157
72ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.28831101
73ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28506367
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27736847
75EP300_21415370_ChIP-Seq_HL-1_Mouse1.27680247
76TFEB_21752829_ChIP-Seq_HELA_Human1.26816477
77ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25833552
78P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24093402
79AHR_22903824_ChIP-Seq_MCF-7_Human1.24045807
80ATF3_27146783_Chip-Seq_COLON_Human1.23580381
81MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.23093683
82* TCF7_22412390_ChIP-Seq_EML_Mouse1.22910543
83IRF8_21731497_ChIP-ChIP_J774_Mouse1.22573825
84FOXA2_19822575_ChIP-Seq_HepG2_Human1.22464323
85FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.22309875
86NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.22240762
87KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21439033
88KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21439033
89KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21439033
90MAF_26560356_Chip-Seq_TH1_Human1.20067692
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19826119
92PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.19802792
93UTX_26944678_Chip-Seq_JUKART_Human1.19454007
94* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19000875
95PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18811957
96TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.18637911
97STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.18461868
98* TBX20_22328084_ChIP-Seq_HEART_Mouse1.18005085
99* TBX20_22080862_ChIP-Seq_HEART_Mouse1.18005085
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17582419
101NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17295570
102HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16062137
103FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15153294
104* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14200742
105FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.13507333
106FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13206439
107GATA4_25053715_ChIP-Seq_YYC3_Human1.13010571
108FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.12788701
109RUNX1_22412390_ChIP-Seq_EML_Mouse1.12194677
110SOX17_20123909_ChIP-Seq_XEN_Mouse1.10958254
111RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10917437
112* GATA3_27048872_Chip-Seq_THYMUS_Human1.10773443
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10291206
114KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09987553
115SPI1_23547873_ChIP-Seq_NB4_Human1.09929933
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09582010
117CHD1_26751641_Chip-Seq_LNCaP_Human1.09552452
118GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09230608
119STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09132541
120ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08238156
121E2F1_21310950_ChIP-Seq_MCF-7_Human1.08152270
122SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07636514
123IRF8_27001747_Chip-Seq_BMDM_Mouse1.07597115
124KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07566097
125GATA4_21415370_ChIP-Seq_HL-1_Mouse1.05824697
126TP63_23658742_ChIP-Seq_EP156T_Human1.05723767
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05452444
128KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05416847
129SCL_19346495_ChIP-Seq_HPC-7_Human1.04764137
130WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04504057
131UBF1/2_26484160_Chip-Seq_HMECs_Human1.04424557
132* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.04368478
133CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04039198
134PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.03986218
135NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03823392
136FOXO3_23340844_ChIP-Seq_DLD1_Human1.03471430
137SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.01789855
138HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01380674
139E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01176212
140NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.01133379
141SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00946085
142CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00801191
143* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00608612
144ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96950000
145PU_27001747_Chip-Seq_BMDM_Mouse0.96791939
146* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96735651
147MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96723688
148TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96663075
149FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96510405
150MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95683564
151RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95361925
152TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94906234
153ELK3_25401928_ChIP-Seq_HUVEC_Human0.94822752
154KDM5A_27292631_Chip-Seq_BREAST_Human0.93498828
155CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92830779
156HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92142355
157ESR2_21235772_ChIP-Seq_MCF-7_Human0.91501845
158GATA6_25053715_ChIP-Seq_YYC3_Human0.91228086
159TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91205515
160CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90569857
161VDR_21846776_ChIP-Seq_THP-1_Human0.90079223

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane3.44411141
2MP0002877_abnormal_melanocyte_morpholog3.43996562
3MP0003806_abnormal_nucleotide_metabolis3.33860924
4MP0005275_abnormal_skin_tensile2.55269017
5MP0003941_abnormal_skin_development2.54262909
6MP0002139_abnormal_hepatobiliary_system2.34887227
7MP0009780_abnormal_chondrocyte_physiolo2.32005876
8MP0005365_abnormal_bile_salt2.22703319
9MP0003705_abnormal_hypodermis_morpholog2.20773507
10MP0010234_abnormal_vibrissa_follicle2.16119702
11MP0005257_abnormal_intraocular_pressure2.11616371
12MP0003300_gastrointestinal_ulcer2.08917262
13MP0004233_abnormal_muscle_weight2.05476344
14MP0008260_abnormal_autophagy1.90005151
15MP0003252_abnormal_bile_duct1.79836003
16MP0003950_abnormal_plasma_membrane1.78972208
17MP0010352_gastrointestinal_tract_polyps1.78406668
18MP0003091_abnormal_cell_migration1.75695252
19MP0005360_urolithiasis1.74557578
20MP0002796_impaired_skin_barrier1.74122700
21MP0005451_abnormal_body_composition1.71593037
22MP0008438_abnormal_cutaneous_collagen1.69761807
23MP0004264_abnormal_extraembryonic_tissu1.58312293
24MP0006054_spinal_hemorrhage1.57131062
25MP0005085_abnormal_gallbladder_physiolo1.55799683
26MP0005220_abnormal_exocrine_pancreas1.54731412
27MP0003566_abnormal_cell_adhesion1.52741212
28MP0001958_emphysema1.48236050
29MP0005623_abnormal_meninges_morphology1.45063064
30MP0002166_altered_tumor_susceptibility1.44528294
31MP0009840_abnormal_foam_cell1.43820705
32MP0001666_abnormal_nutrient_absorption1.42934368
33MP0010307_abnormal_tumor_latency1.41530214
34MP0003279_aneurysm1.40627087
35MP0003693_abnormal_embryo_hatching1.39950638
36MP0002693_abnormal_pancreas_physiology1.39593893
37MP0010678_abnormal_skin_adnexa1.39028200
38MP0002138_abnormal_hepatobiliary_system1.38564281
39MP0002896_abnormal_bone_mineralization1.38289611
40MP0003183_abnormal_peptide_metabolism1.35754649
41MP0001944_abnormal_pancreas_morphology1.34216943
42MP0005083_abnormal_biliary_tract1.32583793
43MP0003221_abnormal_cardiomyocyte_apopto1.30029179
44MP0005503_abnormal_tendon_morphology1.28857578
45MP0005023_abnormal_wound_healing1.28697502
46MP0000767_abnormal_smooth_muscle1.25519279
47MP0005501_abnormal_skin_physiology1.24658602
48MP0008875_abnormal_xenobiotic_pharmacok1.22230976
49MP0009643_abnormal_urine_homeostasis1.22015778
50MP0000609_abnormal_liver_physiology1.21377603
51MP0004782_abnormal_surfactant_physiolog1.20428385
52MP0005076_abnormal_cell_differentiation1.19168768
53MP0005408_hypopigmentation1.16184076
54MP0002295_abnormal_pulmonary_circulatio1.14889973
55MP0010329_abnormal_lipoprotein_level1.14707034
56MP0005164_abnormal_response_to1.13696392
57MP0001542_abnormal_bone_strength1.12866725
58MP0001873_stomach_inflammation1.11841084
59MP0005058_abnormal_lysosome_morphology1.11540112
60MP0002009_preneoplasia1.10243649
61MP0003763_abnormal_thymus_physiology1.09896072
62MP0004808_abnormal_hematopoietic_stem1.09026054
63MP0000627_abnormal_mammary_gland1.09016003
64MP0001243_abnormal_dermal_layer1.06809224
65MP0001835_abnormal_antigen_presentation1.06350872
66MP0010368_abnormal_lymphatic_system1.05673305
67MP0003656_abnormal_erythrocyte_physiolo1.04806730
68MP0003436_decreased_susceptibility_to1.03093415
69MP0001216_abnormal_epidermal_layer1.03063442
70MP0000678_abnormal_parathyroid_gland1.02429812
71MP0008007_abnormal_cellular_replicative1.01542525
72MP0004947_skin_inflammation1.00925596
73MP0002006_tumorigenesis1.00051848
74MP0003195_calcinosis0.98978893
75MP0003191_abnormal_cellular_cholesterol0.98071941
76MP0003448_altered_tumor_morphology0.97646437
77MP0001849_ear_inflammation0.97269759
78MP0000762_abnormal_tongue_morphology0.97152463
79MP0000598_abnormal_liver_morphology0.96669224
80MP0005319_abnormal_enzyme/_coenzyme0.95624699
81MP0003828_pulmonary_edema0.94905099
82MP0000685_abnormal_immune_system0.94706860
83MP0001661_extended_life_span0.94361993
84MP0000490_abnormal_crypts_of0.93708370
85MP0003172_abnormal_lysosome_physiology0.93462806
86MP0008877_abnormal_DNA_methylation0.93280759
87MP0005621_abnormal_cell_physiology0.92281944
88MP0004957_abnormal_blastocyst_morpholog0.92275309
89MP0003186_abnormal_redox_activity0.92242448
90MP0002933_joint_inflammation0.89459181
91MP0002060_abnormal_skin_morphology0.88379030
92MP0002086_abnormal_extraembryonic_tissu0.88120430
93MP0003453_abnormal_keratinocyte_physiol0.87566601
94MP0001915_intracranial_hemorrhage0.87078852
95MP0008961_abnormal_basal_metabolism0.86718280
96MP0001800_abnormal_humoral_immune0.86162307
97MP0005375_adipose_tissue_phenotype0.86021305
98MP0002269_muscular_atrophy0.85623033
99MP0002405_respiratory_system_inflammati0.85313140
100MP0005397_hematopoietic_system_phenotyp0.85112554
101MP0001545_abnormal_hematopoietic_system0.85112554
102MP0003795_abnormal_bone_structure0.84627495
103MP0000858_altered_metastatic_potential0.83927466
104MP0010155_abnormal_intestine_physiology0.83781859
105MP0002254_reproductive_system_inflammat0.83688001
106MP0000465_gastrointestinal_hemorrhage0.83488102
107MP0003077_abnormal_cell_cycle0.83273461
108MP0001881_abnormal_mammary_gland0.83248587
109MP0001879_abnormal_lymphatic_vessel0.83162979
110MP0005310_abnormal_salivary_gland0.83108785
111MP0001845_abnormal_inflammatory_respons0.83065637
112MP0001730_embryonic_growth_arrest0.82446187
113MP0008004_abnormal_stomach_pH0.82326683
114MP0002078_abnormal_glucose_homeostasis0.81818597
115MP0000013_abnormal_adipose_tissue0.80303827
116MP0000377_abnormal_hair_follicle0.79805168
117MP0002837_dystrophic_cardiac_calcinosis0.79626394
118MP0003868_abnormal_feces_composition0.79501550
119MP0003984_embryonic_growth_retardation0.79383600
120MP0000371_diluted_coat_color0.78830920
121MP0005464_abnormal_platelet_physiology0.78311515
122MP0002019_abnormal_tumor_incidence0.76924856
123MP0001764_abnormal_homeostasis0.76836962
124MP0001790_abnormal_immune_system0.76555109
125MP0005387_immune_system_phenotype0.76555109
126MP0001756_abnormal_urination0.76240908
127MP0002088_abnormal_embryonic_growth/wei0.76083595
128MP0002452_abnormal_antigen_presenting0.75840604
129MP0001672_abnormal_embryogenesis/_devel0.75138321
130MP0005380_embryogenesis_phenotype0.75138321
131MP0000689_abnormal_spleen_morphology0.74255963
132MP0010386_abnormal_urinary_bladder0.74073965
133MP0002118_abnormal_lipid_homeostasis0.72062871
134MP0002398_abnormal_bone_marrow0.71969752
135MP0001533_abnormal_skeleton_physiology0.71835226
136MP0005384_cellular_phenotype0.71784259
137MP0002419_abnormal_innate_immunity0.71619490
138MP0002396_abnormal_hematopoietic_system0.71239202
139MP0000733_abnormal_muscle_development0.71052752
140MP0009384_cardiac_valve_regurgitation0.71048693
141MP0001727_abnormal_embryo_implantation0.69992823
142MP0000751_myopathy0.69438598
143MP0002928_abnormal_bile_duct0.69232149
144MP0003943_abnormal_hepatobiliary_system0.68454980
145MP0001614_abnormal_blood_vessel0.68174847
146MP0005165_increased_susceptibility_to0.67976124
147MP0008469_abnormal_protein_level0.67776052
148MP0000003_abnormal_adipose_tissue0.67726327
149MP0005508_abnormal_skeleton_morphology0.67358910
150MP0002998_abnormal_bone_remodeling0.67138291
151MP0010771_integument_phenotype0.66309887
152MP0009697_abnormal_copulation0.66251198
153MP0000462_abnormal_digestive_system0.65305765
154MP0006138_congestive_heart_failure0.65279170
155MP0002722_abnormal_immune_system0.65253236
156MP0004185_abnormal_adipocyte_glucose0.65149904
157MP0005197_abnormal_uvea_morphology0.62271494
158MP0000604_amyloidosis0.62061030
159MP0002098_abnormal_vibrissa_morphology0.61725692
160MP0001299_abnormal_eye_distance/0.60588982
161MP0000467_abnormal_esophagus_morphology0.60486006
162MP0005666_abnormal_adipose_tissue0.58405140
163MP0004858_abnormal_nervous_system0.57990445
164MP0005409_darkened_coat_color0.57870599

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.17526317
2Hypoglycemic coma (HP:0001325)3.75037890
3Vascular tortuosity (HP:0004948)3.58189431
4Arterial tortuosity (HP:0005116)3.57231343
5Atrophic scars (HP:0001075)3.47166386
6Vertebral compression fractures (HP:0002953)3.40342197
7Aortic dissection (HP:0002647)3.19199057
8Abnormality of the intrinsic pathway (HP:0010989)2.90692974
9Hypoglycemic seizures (HP:0002173)2.86901807
10Right ventricular cardiomyopathy (HP:0011663)2.85996846
11Abnormal foot bone ossification (HP:0010675)2.84949660
12Osteolytic defects of the hand bones (HP:0009699)2.82234193
13Osteolytic defects of the phalanges of the hand (HP:0009771)2.82234193
14IgM deficiency (HP:0002850)2.81907062
15Hyperinsulinemic hypoglycemia (HP:0000825)2.80078061
16Hyperglycemia (HP:0003074)2.79800406
17Beaking of vertebral bodies (HP:0004568)2.79428926
18Abnormality of dentin (HP:0010299)2.78052846
19Mitral stenosis (HP:0001718)2.76626025
20Tetraparesis (HP:0002273)2.74382073
21Wormian bones (HP:0002645)2.73190530
22Cervical subluxation (HP:0003308)2.72244256
23Back pain (HP:0003418)2.61466881
24Thrombocytosis (HP:0001894)2.56907450
25Abnormality of aromatic amino acid family metabolism (HP:0004338)2.49776221
26Intrahepatic cholestasis (HP:0001406)2.49043569
27Myocardial infarction (HP:0001658)2.48716154
28Asymmetry of the thorax (HP:0001555)2.47272529
29Insulin-resistant diabetes mellitus (HP:0000831)2.44141652
30Abnormality of the common coagulation pathway (HP:0010990)2.42748845
31Ulnar deviation of the wrist (HP:0003049)2.40449195
32Fragile skin (HP:0001030)2.39406412
33Degeneration of anterior horn cells (HP:0002398)2.38656818
34Abnormality of the anterior horn cell (HP:0006802)2.38656818
35Flat acetabular roof (HP:0003180)2.38176805
36Abnormality of the pancreatic islet cells (HP:0006476)2.38151778
37Abnormality of endocrine pancreas physiology (HP:0012093)2.38151778
38Abnormal pancreas size (HP:0012094)2.37792680
39Ketoacidosis (HP:0001993)2.37381530
40Thoracolumbar scoliosis (HP:0002944)2.34833392
41Renal cortical cysts (HP:0000803)2.34295766
42Short nail (HP:0001799)2.32943986
43Spondylolisthesis (HP:0003302)2.30333945
44Cardiovascular calcification (HP:0011915)2.29483222
45Abnormal tarsal ossification (HP:0008369)2.28120859
46Ankle contracture (HP:0006466)2.27542729
47Mucopolysacchariduria (HP:0008155)2.26966097
48Urinary glycosaminoglycan excretion (HP:0003541)2.26966097
49Abnormal delivery (HP:0001787)2.25441926
50Blue sclerae (HP:0000592)2.22587374
51Follicular hyperkeratosis (HP:0007502)2.21769691
52Metaphyseal cupping (HP:0003021)2.21512323
53Hypoplastic ischia (HP:0003175)2.21317415
54Vacuolated lymphocytes (HP:0001922)2.21099145
55Generalized aminoaciduria (HP:0002909)2.18198204
56Dilatation of the ascending aorta (HP:0005111)2.15771610
57Abnormality of monocarboxylic acid metabolism (HP:0010996)2.15735361
58Abnormality of the fingertips (HP:0001211)2.12746295
59Distal upper limb amyotrophy (HP:0007149)2.12167343
60Upper limb amyotrophy (HP:0009129)2.12167343
61Abnormality of mucopolysaccharide metabolism (HP:0011020)2.10713538
62Abnormality of polysaccharide metabolism (HP:0011012)2.10713538
63Abnormality of glycosaminoglycan metabolism (HP:0004371)2.10713538
64Soft skin (HP:0000977)2.09571776
65Deep venous thrombosis (HP:0002625)2.09369775
66Severe short stature (HP:0003510)2.08056405
67Abnormality of carpal bone ossification (HP:0006257)2.04960121
68Ketosis (HP:0001946)2.04288032
69* Papillary thyroid carcinoma (HP:0002895)2.03951993
70Spinal rigidity (HP:0003306)2.03303644
71Mitral valve prolapse (HP:0001634)2.02682295
72Insulin resistance (HP:0000855)2.01462429
73Elbow flexion contracture (HP:0002987)2.01283487
74Advanced eruption of teeth (HP:0006288)2.00935309
75Termporal pattern (HP:0011008)2.00798007
76Insidious onset (HP:0003587)2.00798007
77Symptomatic seizures (HP:0011145)1.99272721
78Microglossia (HP:0000171)1.98812300
79Abnormality of purine metabolism (HP:0004352)1.98630395
80Natal tooth (HP:0000695)1.98420116
81Long toe (HP:0010511)1.98363600
82Conjugated hyperbilirubinemia (HP:0002908)1.97993440
83Joint laxity (HP:0001388)1.97371674
84Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.95743927
85Autoamputation (HP:0001218)1.94747874
86Vascular calcification (HP:0004934)1.93329111
87Breech presentation (HP:0001623)1.93023211
88Prominent metopic ridge (HP:0005487)1.92717524
89Cerebral aneurysm (HP:0004944)1.92426451
90Epiphyseal dysplasia (HP:0002656)1.92167856
91Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.91925595
92Hyperextensible skin (HP:0000974)1.91792770
93Aortic aneurysm (HP:0004942)1.91778205
94Abnormality of T cell physiology (HP:0011840)1.90578869
95Micronodular cirrhosis (HP:0001413)1.90164046
96Unilateral renal agenesis (HP:0000122)1.87808063
97Malnutrition (HP:0004395)1.87356964
98Abnormality of the ischium (HP:0003174)1.87123929
99Abnormality of liposaccharide metabolism (HP:0010968)1.86584873
100Abnormality of glycosphingolipid metabolism (HP:0004343)1.86584873
101Abnormality of glycolipid metabolism (HP:0010969)1.86584873
102Late onset (HP:0003584)1.86057765
103Protuberant abdomen (HP:0001538)1.85612784
104Bladder diverticulum (HP:0000015)1.85588308
105Cupped ribs (HP:0000887)1.85332464
106Asymmetric septal hypertrophy (HP:0001670)1.84057161
107Polycythemia (HP:0001901)1.83752584
108Global brain atrophy (HP:0002283)1.83142959
109Ankyloglossia (HP:0010296)1.82779962
110Esophageal varix (HP:0002040)1.82335714
111Gout (HP:0001997)1.81809347
112Dysostosis multiplex (HP:0000943)1.81744105
113Epidermoid cyst (HP:0200040)1.80940541
114Neonatal short-limb short stature (HP:0008921)1.80853835
115Generalized amyotrophy (HP:0003700)1.79815285
116Colitis (HP:0002583)1.79802217
117Pancreatic islet-cell hyperplasia (HP:0004510)1.78170443
118Xanthomatosis (HP:0000991)1.78104051
119Abdominal distention (HP:0003270)1.77711217
120Increased mean platelet volume (HP:0011877)1.77200184
121Curly hair (HP:0002212)1.76483831
122Nasal polyposis (HP:0100582)1.74962314
123Abnormality of the nasal mucosa (HP:0000433)1.74292038
124Peritonitis (HP:0002586)1.73567963
125Facial diplegia (HP:0001349)1.72721965
126Hypobetalipoproteinemia (HP:0003563)1.72714041
127Hand muscle atrophy (HP:0009130)1.72248488
128Pterygium (HP:0001059)1.70888462
129Flattened epiphyses (HP:0003071)1.70796125
130Abnormality of the thoracic spine (HP:0100711)1.70764783
131Abnormality of small intestinal villus morphology (HP:0011472)1.70614832
132Villous atrophy (HP:0011473)1.70614832
133Protrusio acetabuli (HP:0003179)1.70132754
134Mildly elevated creatine phosphokinase (HP:0008180)1.69587689
135Ovoid vertebral bodies (HP:0003300)1.68870673
136Abnormal platelet volume (HP:0011876)1.67911735
137Thoracic kyphosis (HP:0002942)1.67550583
138Fatigue (HP:0012378)1.66815124
139Irregular epiphyses (HP:0010582)1.66790273
140Male infertility (HP:0003251)1.66675050
141Recurrent bronchitis (HP:0002837)1.66124499
142Prolonged partial thromboplastin time (HP:0003645)1.65251831
143Flat capital femoral epiphysis (HP:0003370)1.65142612
144Large for gestational age (HP:0001520)1.64583371
145Fat malabsorption (HP:0002630)1.64228225
146Spinal cord compression (HP:0002176)1.63622629
147Hypolipoproteinemia (HP:0010981)1.63350486
148Abnormality of fatty-acid metabolism (HP:0004359)1.63015157
149Gastrointestinal inflammation (HP:0004386)1.62929675
150Abnormal delayed hypersensitivity skin test (HP:0002963)1.62730693
151Aneurysm (HP:0002617)1.62351291
152Platyspondyly (HP:0000926)1.61753012
153Coxa valga (HP:0002673)1.61671608
154Hypoalphalipoproteinemia (HP:0003233)1.61287737
155Glucose intolerance (HP:0000833)1.61277105
156Abnormality of oral frenula (HP:0000190)1.61147526
157Limb hypertonia (HP:0002509)1.61130597
158Abnormal gallbladder physiology (HP:0012438)1.61072494
159Cholecystitis (HP:0001082)1.61072494
160Reduced subcutaneous adipose tissue (HP:0003758)1.61010818
161Coarse hair (HP:0002208)1.60842299
162Upper limb muscle weakness (HP:0003484)1.60841698
163Abnormality of the acetabulum (HP:0003170)1.60552671
164Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.60511196
165Abnormality of the Achilles tendon (HP:0005109)1.59067606
166Thin bony cortex (HP:0002753)1.58788261
167Abnormality of the distal phalanges of the toes (HP:0010182)1.58144329
168Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.57526678
169Alopecia of scalp (HP:0002293)1.57466167
170Genu recurvatum (HP:0002816)1.55511718
171Testicular neoplasm (HP:0010788)1.55498823
172Limb-girdle muscle weakness (HP:0003325)1.55005215
173Abnormal ossification of hand bones (HP:0005921)1.54902948

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K2.99492750
2EIF2AK12.98531885
3PKN22.88769583
4TAOK32.82572915
5FLT32.69513451
6TRIB32.62134428
7PASK2.58502433
8MET2.54228908
9ERN12.50343130
10MAP3K122.47755268
11MST1R2.33764953
12MYLK2.11492333
13MST42.11051678
14MAPKAPK32.06576975
15LATS22.04164112
16STK102.01161000
17TIE11.99675152
18FRK1.96376743
19JAK31.93145177
20RPS6KA41.81284898
21RIPK11.76857589
22DDR21.67507299
23FER1.63108838
24MAP3K31.61310332
25PRKD31.60584641
26IRAK31.56915601
27ZAP701.54362221
28MAP2K31.51979435
29MAP4K11.50726794
30TTN1.49096267
31PBK1.48867046
32SIK11.45611688
33LATS11.43514245
34STK241.39989759
35NEK21.36532458
36CDC71.35178668
37BCKDK1.34772328
38MAP3K131.33497830
39RPS6KB21.32648813
40MOS1.31181157
41AKT31.30496292
42SCYL21.29953991
43FGFR41.27463308
44BRSK21.27201467
45TYK21.25880709
46PDK41.25848591
47PDK31.25848591
48NEK91.24364535
49KSR11.21979649
50HIPK21.21831631
51PTK61.19414425
52TGFBR21.19141117
53DYRK31.17782849
54NEK11.17114956
55TESK11.13786740
56ERBB31.13469709
57LIMK11.11002046
58MAP3K81.06497451
59BRD41.05591948
60STK31.05091428
61EIF2AK31.03741259
62ACVR1B1.02659506
63ERBB41.02246007
64NEK61.01981230
65MAP3K101.01368409
66MARK30.99424260
67ICK0.94895309
68PIK3CG0.93756785
69NLK0.93145210
70TBK10.92696725
71LRRK20.92102634
72STK38L0.90197925
73CHUK0.88788720
74KSR20.88644942
75FGR0.87117163
76BCR0.86454827
77JAK20.86271504
78STK380.85895135
79EPHA30.84582923
80PDK20.83615905
81NTRK10.82852748
82JAK10.81753233
83PAK20.80071895
84PAK40.78125519
85PDGFRA0.77789418
86LMTK20.75946683
87ILK0.75779473
88PDGFRB0.73864666
89BTK0.72722172
90TRPM70.71990472
91ITK0.71689847
92EPHA20.71245831
93ROCK20.70672495
94MTOR0.70616594
95MAPK110.70462328
96FGFR30.69503851
97PRPF4B0.69417388
98CAMK1D0.68570768
99YES10.68556604
100MAP3K140.66940411
101ARAF0.66704480
102CDK90.66313035
103TTK0.66248303
104BMX0.60756128
105PRKD20.60627024
106SGK30.60460960
107TEC0.59038044
108EPHB10.58232303
109CDK120.57550139
110FGFR10.57001823
111PIM10.56081202
112IKBKE0.55815224
113MAPK150.55443865
114EPHB20.55262440
115RET0.55005175
116MAP2K60.54883101
117PTK20.53630870
118CSF1R0.52993082
119CDC42BPA0.52642894
120AKT20.52205698
121TGFBR10.51924699
122MAP3K20.51781252
123INSRR0.51573058
124MAP3K60.50557492
125KIT0.50127367
126DYRK1B0.48990746
127CDK70.48049977
128MAP3K90.47886037
129STK40.47376204
130IRAK40.45890156
131MUSK0.44976423
132RAF10.44413443
133MELK0.44323441
134BRAF0.43962493
135SIK30.41669070
136PRKG20.41542231
137CDK60.40798319
138MAP3K50.40109282
139AURKB0.39028675
140PDK10.38920658
141CDK40.38301317
142CAMK1G0.37749942
143MAP2K10.37730282
144TAOK20.35331112
145ROCK10.35250583
146DMPK0.33945649
147TSSK60.33917523
148PIK3CA0.33518342

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.00995060
2Protein export_Homo sapiens_hsa030602.53356056
3Selenocompound metabolism_Homo sapiens_hsa004502.51792155
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.28388174
5Adherens junction_Homo sapiens_hsa045201.81953012
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.81140418
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.74981022
8Sulfur metabolism_Homo sapiens_hsa009201.73509482
9Folate biosynthesis_Homo sapiens_hsa007901.67423643
10Caffeine metabolism_Homo sapiens_hsa002321.65814071
11Drug metabolism - other enzymes_Homo sapiens_hsa009831.65269045
12Vibrio cholerae infection_Homo sapiens_hsa051101.59093694
13Pentose and glucuronate interconversions_Homo sapiens_hsa000401.52307867
14Proteoglycans in cancer_Homo sapiens_hsa052051.47594951
15Starch and sucrose metabolism_Homo sapiens_hsa005001.46203915
16Fatty acid degradation_Homo sapiens_hsa000711.45702052
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.40539857
18Antigen processing and presentation_Homo sapiens_hsa046121.38168033
19Central carbon metabolism in cancer_Homo sapiens_hsa052301.36938047
20Pentose phosphate pathway_Homo sapiens_hsa000301.36922779
21Tryptophan metabolism_Homo sapiens_hsa003801.30970875
22Insulin resistance_Homo sapiens_hsa049311.27174955
23Galactose metabolism_Homo sapiens_hsa000521.26508260
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25377792
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.23037408
26Legionellosis_Homo sapiens_hsa051341.21387491
27Other glycan degradation_Homo sapiens_hsa005111.19750252
28Fructose and mannose metabolism_Homo sapiens_hsa000511.18649132
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.18504229
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16622833
31Steroid biosynthesis_Homo sapiens_hsa001001.15592070
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14794035
33Circadian rhythm_Homo sapiens_hsa047101.14705481
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14304134
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.13597478
36Sphingolipid metabolism_Homo sapiens_hsa006001.13501113
37Fat digestion and absorption_Homo sapiens_hsa049751.10107143
38Nitrogen metabolism_Homo sapiens_hsa009101.07766716
39Renal cell carcinoma_Homo sapiens_hsa052111.07542729
40Cell cycle_Homo sapiens_hsa041101.07511965
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04518402
42Bladder cancer_Homo sapiens_hsa052191.03686431
43Propanoate metabolism_Homo sapiens_hsa006401.02850017
44Fatty acid elongation_Homo sapiens_hsa000621.01291275
45Endometrial cancer_Homo sapiens_hsa052131.00526645
46TGF-beta signaling pathway_Homo sapiens_hsa043500.99679520
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99130281
48Shigellosis_Homo sapiens_hsa051310.98116035
49Prion diseases_Homo sapiens_hsa050200.97253467
50Lysine degradation_Homo sapiens_hsa003100.93887078
51Prolactin signaling pathway_Homo sapiens_hsa049170.93500396
52Complement and coagulation cascades_Homo sapiens_hsa046100.93245067
53Regulation of actin cytoskeleton_Homo sapiens_hsa048100.93168917
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93059151
55ABC transporters_Homo sapiens_hsa020100.91771013
56Peroxisome_Homo sapiens_hsa041460.87584294
57Thyroid cancer_Homo sapiens_hsa052160.84797328
58Toxoplasmosis_Homo sapiens_hsa051450.83520825
59Chemical carcinogenesis_Homo sapiens_hsa052040.83025145
60Tight junction_Homo sapiens_hsa045300.82583557
61Leishmaniasis_Homo sapiens_hsa051400.82242321
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81972143
63Endocytosis_Homo sapiens_hsa041440.81925732
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.79967839
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79718467
66Histidine metabolism_Homo sapiens_hsa003400.79608265
67RNA degradation_Homo sapiens_hsa030180.79292381
68Glutathione metabolism_Homo sapiens_hsa004800.79148760
69PPAR signaling pathway_Homo sapiens_hsa033200.78229664
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78123725
71HIF-1 signaling pathway_Homo sapiens_hsa040660.76993644
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76613292
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76552546
74Protein digestion and absorption_Homo sapiens_hsa049740.76528793
75Insulin signaling pathway_Homo sapiens_hsa049100.76383614
76One carbon pool by folate_Homo sapiens_hsa006700.74530612
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74027726
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73648283
79Viral carcinogenesis_Homo sapiens_hsa052030.72448892
80p53 signaling pathway_Homo sapiens_hsa041150.72172169
81Arginine and proline metabolism_Homo sapiens_hsa003300.71935444
82Fatty acid biosynthesis_Homo sapiens_hsa000610.71583729
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71111504
84PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70139748
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69789518
86Lysosome_Homo sapiens_hsa041420.69155880
87B cell receptor signaling pathway_Homo sapiens_hsa046620.68051393
88Herpes simplex infection_Homo sapiens_hsa051680.67957417
89Hepatitis C_Homo sapiens_hsa051600.67955573
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67435357
91Regulation of autophagy_Homo sapiens_hsa041400.66845123
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66820586
93Salmonella infection_Homo sapiens_hsa051320.66268520
94Apoptosis_Homo sapiens_hsa042100.65636241
95Influenza A_Homo sapiens_hsa051640.65145874
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64273716
97TNF signaling pathway_Homo sapiens_hsa046680.62556230
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61707891
99AMPK signaling pathway_Homo sapiens_hsa041520.61565492
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61267879
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.60882832
102Renin-angiotensin system_Homo sapiens_hsa046140.60794502
103MicroRNAs in cancer_Homo sapiens_hsa052060.59892186
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.59524498
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59472300
106N-Glycan biosynthesis_Homo sapiens_hsa005100.59366925
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59303066
108Carbon metabolism_Homo sapiens_hsa012000.59240611
109Chronic myeloid leukemia_Homo sapiens_hsa052200.59031892
110Inositol phosphate metabolism_Homo sapiens_hsa005620.58880398
111Arginine biosynthesis_Homo sapiens_hsa002200.58362943
112Primary immunodeficiency_Homo sapiens_hsa053400.58055697
113mTOR signaling pathway_Homo sapiens_hsa041500.57904683
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.57551480
115Pyruvate metabolism_Homo sapiens_hsa006200.56568439
116Glucagon signaling pathway_Homo sapiens_hsa049220.56355998
117RNA transport_Homo sapiens_hsa030130.55968991
118Osteoclast differentiation_Homo sapiens_hsa043800.55709871
119Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55455645
120ErbB signaling pathway_Homo sapiens_hsa040120.55216311
121Small cell lung cancer_Homo sapiens_hsa052220.55180225
122Non-small cell lung cancer_Homo sapiens_hsa052230.54416885
123Mineral absorption_Homo sapiens_hsa049780.53966916
124FoxO signaling pathway_Homo sapiens_hsa040680.53604322
125beta-Alanine metabolism_Homo sapiens_hsa004100.53598980
126Biosynthesis of amino acids_Homo sapiens_hsa012300.53055199
127Linoleic acid metabolism_Homo sapiens_hsa005910.52884257
128Measles_Homo sapiens_hsa051620.52710974
129Fatty acid metabolism_Homo sapiens_hsa012120.51158490
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50423989
131ECM-receptor interaction_Homo sapiens_hsa045120.50213178
132HTLV-I infection_Homo sapiens_hsa051660.50141430
133Cysteine and methionine metabolism_Homo sapiens_hsa002700.49928179
134Phenylalanine metabolism_Homo sapiens_hsa003600.48916770
135Prostate cancer_Homo sapiens_hsa052150.48667285
136Glioma_Homo sapiens_hsa052140.48337969
137Phagosome_Homo sapiens_hsa041450.46839561
138Acute myeloid leukemia_Homo sapiens_hsa052210.46701477
139Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45712527
140Focal adhesion_Homo sapiens_hsa045100.45653120
141Hepatitis B_Homo sapiens_hsa051610.45630552
142Hippo signaling pathway_Homo sapiens_hsa043900.45480972
143Pancreatic cancer_Homo sapiens_hsa052120.45004900
144Staphylococcus aureus infection_Homo sapiens_hsa051500.43523144
145Amoebiasis_Homo sapiens_hsa051460.43292577
146Pathways in cancer_Homo sapiens_hsa052000.42329846

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »