GOLGA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes a member of the golgin family of proteins which are localized to the Golgi. Its encoded protein has been postulated to play a role in nuclear transport and Golgi apparatus localization. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.37839681
2Golgi transport vesicle coating (GO:0048200)5.37839681
3plasma membrane repair (GO:0001778)4.48266485
4protein targeting to Golgi (GO:0000042)4.08782915
5retrograde transport, vesicle recycling within Golgi (GO:0000301)3.96025910
6cilium or flagellum-dependent cell motility (GO:0001539)3.94610954
7establishment of protein localization to Golgi (GO:0072600)3.90494395
8macroautophagy (GO:0016236)3.85779010
9retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.83915464
10negative regulation of fatty acid transport (GO:2000192)3.76425884
11COPII vesicle coating (GO:0048208)3.69643995
12hemidesmosome assembly (GO:0031581)3.69202907
13maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.68822623
14skin morphogenesis (GO:0043589)3.68758434
15positive regulation of p38MAPK cascade (GO:1900745)3.65168671
16activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.62942132
17ER overload response (GO:0006983)3.56532793
18cell-substrate junction assembly (GO:0007044)3.47131488
19piRNA metabolic process (GO:0034587)3.42380826
20protein localization to endosome (GO:0036010)3.36010836
21inner ear receptor cell development (GO:0060119)3.35228888
22positive regulation of nuclease activity (GO:0032075)3.34652873
23negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.33349801
24regulation of p38MAPK cascade (GO:1900744)3.26875687
25fibroblast migration (GO:0010761)3.20703910
26cytoskeletal anchoring at plasma membrane (GO:0007016)3.17592016
27sequestering of extracellular ligand from receptor (GO:0035581)3.16877251
28endodermal cell differentiation (GO:0035987)3.15988812
29vesicle coating (GO:0006901)3.14444355
30endoplasmic reticulum unfolded protein response (GO:0030968)3.13213926
31negative regulation of potassium ion transmembrane transport (GO:1901380)3.11205498
32acrosome assembly (GO:0001675)3.09028940
33cellular response to unfolded protein (GO:0034620)3.08368868
34ER-nucleus signaling pathway (GO:0006984)3.06102385
35regulation of nuclease activity (GO:0032069)3.05903107
36cellular response to vitamin D (GO:0071305)3.05820805
37positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.04534607
38desmosome organization (GO:0002934)3.04136495
39synaptonemal complex organization (GO:0070193)3.02194448
40protein retention in ER lumen (GO:0006621)3.00633048
41pericardium development (GO:0060039)3.00403730
42regulation of fatty acid beta-oxidation (GO:0031998)2.99197133
43regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.98516250
44relaxation of cardiac muscle (GO:0055119)2.96623822
45insulin-like growth factor receptor signaling pathway (GO:0048009)2.96137045
46cellular response to vitamin (GO:0071295)2.94867851
47basement membrane organization (GO:0071711)2.94168147
48* intra-Golgi vesicle-mediated transport (GO:0006891)2.92929935
49adherens junction assembly (GO:0034333)2.91313957
50growth hormone receptor signaling pathway (GO:0060396)2.91132741
51regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.90943100
52synaptonemal complex assembly (GO:0007130)2.90118523
53sarcoplasmic reticulum calcium ion transport (GO:0070296)2.89448602
54cardiac myofibril assembly (GO:0055003)2.88065429
55myofibril assembly (GO:0030239)2.87753429
56wound healing, spreading of epidermal cells (GO:0035313)2.87082554
57type B pancreatic cell development (GO:0003323)2.86209302
58cell-substrate adherens junction assembly (GO:0007045)2.86125910
59focal adhesion assembly (GO:0048041)2.86125910
60male meiosis (GO:0007140)2.85746536
61regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.85698697
62positive regulation of blood vessel endothelial cell migration (GO:0043536)2.84337946
63protein heterotrimerization (GO:0070208)2.83115598
64cell migration involved in heart development (GO:0060973)2.82445240
65endothelial cell chemotaxis (GO:0035767)2.81753935
66cellular response to topologically incorrect protein (GO:0035967)2.79853538
67protein hydroxylation (GO:0018126)2.76588656
68sarcomere organization (GO:0045214)2.75634191
69endocardial cushion development (GO:0003197)2.75388674
70mannose metabolic process (GO:0006013)2.74421491
71iron ion import (GO:0097286)2.73079137
72collagen fibril organization (GO:0030199)2.72580594
73regulation of axon extension involved in axon guidance (GO:0048841)2.72164655
74protein localization to Golgi apparatus (GO:0034067)2.68319704
75peptide hormone processing (GO:0016486)2.67707365
76sequestering of metal ion (GO:0051238)2.67648793
77positive regulation of histone deacetylation (GO:0031065)2.66038843
78negative regulation of axon extension involved in axon guidance (GO:0048843)2.65323078
79negative regulation of cell size (GO:0045792)2.64580218
80endocrine pancreas development (GO:0031018)2.63456131
81positive regulation of glycolytic process (GO:0045821)2.63028849
82sperm motility (GO:0030317)2.62405895
83histone H3-K36 demethylation (GO:0070544)2.61816249
84ganglion development (GO:0061548)2.61706782
85vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.61512247
86vascular endothelial growth factor signaling pathway (GO:0038084)2.60716793
87semaphorin-plexin signaling pathway (GO:0071526)2.58325265
88regulation of hippo signaling (GO:0035330)2.58176681
89platelet-derived growth factor receptor signaling pathway (GO:0048008)2.58081734
90regulation of protein polyubiquitination (GO:1902914)2.57888443
91cell adhesion mediated by integrin (GO:0033627)2.55321231
92epithelial cell-cell adhesion (GO:0090136)2.54474884
93positive regulation of fatty acid beta-oxidation (GO:0032000)2.54396806
94coronary vasculature morphogenesis (GO:0060977)2.53695283
95response to endoplasmic reticulum stress (GO:0034976)2.52703263
96response to unfolded protein (GO:0006986)2.52496738
97regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.51962378
98UDP-N-acetylglucosamine metabolic process (GO:0006047)2.51770662
99cell migration involved in sprouting angiogenesis (GO:0002042)2.51466691
100regulation of type B pancreatic cell apoptotic process (GO:2000674)2.50269995
101regulation of endothelial cell chemotaxis (GO:2001026)2.49573767
102retina vasculature morphogenesis in camera-type eye (GO:0061299)2.49403981
103collagen metabolic process (GO:0032963)2.49269475
104regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.48799877
105endocrine hormone secretion (GO:0060986)2.48692233
106regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.47429370
107cytoplasmic mRNA processing body assembly (GO:0033962)2.47158040
108glomerular basement membrane development (GO:0032836)2.46836609
109insulin secretion (GO:0030073)2.46625905
110exocrine pancreas development (GO:0031017)2.46565006
111cellular response to growth hormone stimulus (GO:0071378)2.46381251
112actin filament depolymerization (GO:0030042)2.46098551
113blood vessel maturation (GO:0001955)2.43512002
114replicative senescence (GO:0090399)2.42827957
115peptidyl-proline hydroxylation (GO:0019511)2.41401849
1164-hydroxyproline metabolic process (GO:0019471)2.41390549
117atrioventricular valve morphogenesis (GO:0003181)2.41327982
118positive regulation of fibroblast migration (GO:0010763)2.41261800
119pyrimidine ribonucleoside catabolic process (GO:0046133)2.38788320
120collagen catabolic process (GO:0030574)2.38085445
121cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.37845041
122regulation of hexokinase activity (GO:1903299)2.37762165
123regulation of glucokinase activity (GO:0033131)2.37762165
124cellular response to ATP (GO:0071318)2.37627584
125regulation of extracellular matrix disassembly (GO:0010715)2.37581555
126glomerular visceral epithelial cell development (GO:0072015)2.37273420
127glandular epithelial cell development (GO:0002068)2.37217743
128negative regulation of anoikis (GO:2000811)2.36918464
129monoubiquitinated protein deubiquitination (GO:0035520)2.36844226
130actomyosin structure organization (GO:0031032)2.36389253
131negative regulation of organelle assembly (GO:1902116)2.36315498
132multicellular organismal macromolecule metabolic process (GO:0044259)2.35941687
133detection of calcium ion (GO:0005513)2.35807336
134positive regulation of receptor recycling (GO:0001921)2.35137489
135dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.34954575
136negative regulation of glycogen biosynthetic process (GO:0045719)2.34097674
137regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.33237467
138substrate-dependent cell migration (GO:0006929)2.33034441
139positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.32827605
140neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.31578546
141renal filtration (GO:0097205)2.31395796
142response to topologically incorrect protein (GO:0035966)2.31307125
143growth hormone secretion (GO:0030252)2.31055921
144myoblast fusion (GO:0007520)2.30737613
145tooth mineralization (GO:0034505)2.30570413
146fusion of sperm to egg plasma membrane (GO:0007342)2.30516273
147chondrocyte proliferation (GO:0035988)2.30100143
148multicellular organismal metabolic process (GO:0044236)2.29957778
149chondrocyte development (GO:0002063)2.29815346
150face morphogenesis (GO:0060325)2.29620321
151nuclear pore complex assembly (GO:0051292)2.29597665
152negative regulation of TOR signaling (GO:0032007)2.29156038
153regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.29146355
154lactate metabolic process (GO:0006089)2.29032803
155nucleoside diphosphate catabolic process (GO:0009134)2.28885051
156type B pancreatic cell proliferation (GO:0044342)2.28662297
157regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.27733701
158Golgi organization (GO:0007030)2.27556323
159regulation of transforming growth factor beta1 production (GO:0032908)2.26047994
160extracellular matrix disassembly (GO:0022617)2.25978187
161regulation of cardioblast proliferation (GO:0003264)2.25509223
162regulation of secondary heart field cardioblast proliferation (GO:0003266)2.25509223
163positive regulation of glycogen biosynthetic process (GO:0045725)2.23981692
164phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.23660506
165regulation of cholesterol homeostasis (GO:2000188)2.23545996
166sprouting angiogenesis (GO:0002040)2.23325113
167columnar/cuboidal epithelial cell development (GO:0002066)2.22263541
168multicellular organismal catabolic process (GO:0044243)2.20956400
169substrate adhesion-dependent cell spreading (GO:0034446)2.20880159
170actin cytoskeleton reorganization (GO:0031532)2.20821726
171wound healing, spreading of cells (GO:0044319)2.20526658
172venous blood vessel morphogenesis (GO:0048845)2.20513678
173endocytic recycling (GO:0032456)2.19215529
174regulation of axon guidance (GO:1902667)2.18658474
175regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.15863147
176blood vessel endothelial cell migration (GO:0043534)2.15844815

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.94917924
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.13683232
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.82678997
4ESR2_21235772_ChIP-Seq_MCF-7_Human2.66055495
5HIF1A_21447827_ChIP-Seq_MCF-7_Human2.33869756
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.20005046
7EZH2_22144423_ChIP-Seq_EOC_Human2.04855182
8RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.03012917
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.02125060
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.01328609
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.95994782
12SALL1_21062744_ChIP-ChIP_HESCs_Human1.94764595
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87805741
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.87546937
15SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.85974681
16SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.85974681
17ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.83850893
18ZNF217_24962896_ChIP-Seq_MCF-7_Human1.81864642
19ELK3_25401928_ChIP-Seq_HUVEC_Human1.73276722
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72999817
21EP300_21415370_ChIP-Seq_HL-1_Mouse1.72397497
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70409937
23KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.70335040
24GBX2_23144817_ChIP-Seq_PC3_Human1.70198056
25P300_27058665_Chip-Seq_ZR-75-30cells_Human1.69864634
26GATA1_22025678_ChIP-Seq_K562_Human1.69618912
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65976340
28CLOCK_20551151_ChIP-Seq_293T_Human1.65724596
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63543949
30RACK7_27058665_Chip-Seq_MCF-7_Human1.61397701
31AHR_22903824_ChIP-Seq_MCF-7_Human1.53565986
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52637802
33TP53_22127205_ChIP-Seq_IMR90_Human1.50924784
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49041973
35RUNX1_27514584_Chip-Seq_MCF-7_Human1.44012031
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.43633044
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39858515
38CJUN_26792858_Chip-Seq_BT549_Human1.39724680
39SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39060721
40STAT3_23295773_ChIP-Seq_U87_Human1.38887844
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38417370
42DROSHA_22980978_ChIP-Seq_HELA_Human1.37370782
43TBX20_22328084_ChIP-Seq_HEART_Mouse1.37277227
44TBX20_22080862_ChIP-Seq_HEART_Mouse1.37277227
45ARNT_22903824_ChIP-Seq_MCF-7_Human1.37124586
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36521809
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.36301315
48KDM2B_26808549_Chip-Seq_K562_Human1.33807945
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.33345295
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.33059077
51SMAD4_21799915_ChIP-Seq_A2780_Human1.32953644
52TP53_16413492_ChIP-PET_HCT116_Human1.32938779
53HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.31689350
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29264372
55UBF1/2_26484160_Chip-Seq_HMECs_Human1.29175895
56TP53_23651856_ChIP-Seq_MEFs_Mouse1.29141755
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28975832
58FOXA2_19822575_ChIP-Seq_HepG2_Human1.28850796
59TCF4_23295773_ChIP-Seq_U87_Human1.28508403
60CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.28234865
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27969112
62NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.27703762
63KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27481397
64* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26367801
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25073993
66SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22198565
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.22015789
68SOX2_27498859_Chip-Seq_STOMACH_Mouse1.21484461
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20639290
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20472768
71ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19292618
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19124938
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19083638
74ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18623758
75ATF3_27146783_Chip-Seq_COLON_Human1.17966596
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17884059
77CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17503177
78CDX2_22108803_ChIP-Seq_LS180_Human1.17391324
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17354345
80Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16453557
81BRD4_25478319_ChIP-Seq_HGPS_Human1.16179737
82JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15055862
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15024996
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.14925618
85FOXO3_23340844_ChIP-Seq_DLD1_Human1.14291365
86EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14275570
87SMAD_19615063_ChIP-ChIP_OVARY_Human1.13874809
88WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11568426
89TCF7_22412390_ChIP-Seq_EML_Mouse1.11390214
90DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11114020
91ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10675878
92NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10400252
93PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10316258
94ESR1_21235772_ChIP-Seq_MCF-7_Human1.09108107
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08953260
96TCF4_18268006_ChIP-ChIP_LS174T_Human1.07829806
97NFE2_27457419_Chip-Seq_LIVER_Mouse1.06656658
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.05680042
99ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05646977
100GATA1_19941826_ChIP-Seq_K562_Human1.05580404
101CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05402001
102TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04941836
103NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04859236
104PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04830313
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04500861
106EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04050548
107FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.03956376
108FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.03470889
109TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02908805
110NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02544723
111NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02544723
112FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02272198
113TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01999776
114STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.01804705
115E2F1_18555785_Chip-Seq_ESCs_Mouse1.01710748
116GATA6_25053715_ChIP-Seq_YYC3_Human1.01597820
117TP53_18474530_ChIP-ChIP_U2OS_Human0.99751541
118BCAT_22108803_ChIP-Seq_LS180_Human0.99732863
119KDM2B_26808549_Chip-Seq_DND41_Human0.99500925
120EZH2_27294783_Chip-Seq_NPCs_Mouse0.99153829
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98928533
122NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98715152
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98699662
124WT1_19549856_ChIP-ChIP_CCG9911_Human0.98440194
125P53_22387025_ChIP-Seq_ESCs_Mouse0.97938026
126CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97566947
127ISL1_27105846_Chip-Seq_CPCs_Mouse0.97316784
128ESR1_20079471_ChIP-ChIP_T-47D_Human0.96940301
129ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96401056
130NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96239592
131SOX2_20726797_ChIP-Seq_SW620_Human0.96183474
132TP63_23658742_ChIP-Seq_EP156T_Human0.95484828
133SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95441873
134SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95338411
135JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95247640
136NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94957831
137AR_19668381_ChIP-Seq_PC3_Human0.94874287
138VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94694820
139PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94563620
140AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94130874
141MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.94080838
142* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93450995
143FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.93340347
144LXR_22158963_ChIP-Seq_LIVER_Mouse0.92775967
145STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92483053
146YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92470360
147PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91551910
148IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.90904186
149ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90817348
150CMYC_18555785_Chip-Seq_ESCs_Mouse0.90775360
151TET1_21490601_ChIP-Seq_MESCs_Mouse0.90642197
152RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90553264
153KLF5_25053715_ChIP-Seq_YYC3_Human0.90394963
154* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90223305

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.47274431
2MP0000569_abnormal_digit_pigmentation4.31187770
3MP0002877_abnormal_melanocyte_morpholog4.03844227
4MP0002837_dystrophic_cardiac_calcinosis3.42288570
5MP0009780_abnormal_chondrocyte_physiolo3.11666468
6MP0003045_fibrosis3.04135633
7MP0005623_abnormal_meninges_morphology2.65657043
8MP0005503_abnormal_tendon_morphology2.63391993
9MP0010234_abnormal_vibrissa_follicle2.57790808
10MP0005275_abnormal_skin_tensile2.51027209
11MP0003300_gastrointestinal_ulcer2.49656269
12MP0000013_abnormal_adipose_tissue2.48084952
13MP0004084_abnormal_cardiac_muscle2.38828493
14MP0003950_abnormal_plasma_membrane2.37265919
15MP0004036_abnormal_muscle_relaxation2.36879223
16MP0005409_darkened_coat_color2.22802248
17MP0000751_myopathy2.15204043
18MP0005076_abnormal_cell_differentiation2.14389654
19MP0009840_abnormal_foam_cell2.13479277
20MP0002909_abnormal_adrenal_gland2.12133857
21MP0005410_abnormal_fertilization2.08666298
22MP0003705_abnormal_hypodermis_morpholog2.06701726
23MP0000003_abnormal_adipose_tissue2.03813071
24MP0002693_abnormal_pancreas_physiology2.03432196
25MP0001299_abnormal_eye_distance/1.96307641
26MP0003283_abnormal_digestive_organ1.94104604
27MP0002928_abnormal_bile_duct1.91158325
28MP0005023_abnormal_wound_healing1.88606705
29MP0004043_abnormal_pH_regulation1.82602371
30MP0010386_abnormal_urinary_bladder1.81633871
31MP0010368_abnormal_lymphatic_system1.81352987
32MP0009384_cardiac_valve_regurgitation1.75524115
33MP0001944_abnormal_pancreas_morphology1.69335796
34MP0003279_aneurysm1.67001492
35MP0002896_abnormal_bone_mineralization1.66769380
36MP0003566_abnormal_cell_adhesion1.61823724
37MP0002168_other_aberrant_phenotype1.60468766
38MP0002234_abnormal_pharynx_morphology1.58410709
39MP0008877_abnormal_DNA_methylation1.56485847
40MP0004087_abnormal_muscle_fiber1.56225464
41MP0005670_abnormal_white_adipose1.53932165
42MP0004145_abnormal_muscle_electrophysio1.52036852
43MP0003252_abnormal_bile_duct1.51301829
44MP0000749_muscle_degeneration1.49605255
45MP0005375_adipose_tissue_phenotype1.39616686
46MP0005220_abnormal_exocrine_pancreas1.38362556
47MP0005257_abnormal_intraocular_pressure1.34168944
48MP0001243_abnormal_dermal_layer1.33037169
49MP0002269_muscular_atrophy1.32698125
50MP0010630_abnormal_cardiac_muscle1.32100066
51MP0004272_abnormal_basement_membrane1.31917913
52MP0006054_spinal_hemorrhage1.30913746
53MP0010352_gastrointestinal_tract_polyps1.28263364
54MP0010307_abnormal_tumor_latency1.23502825
55MP0002108_abnormal_muscle_morphology1.22518334
56MP0001661_extended_life_span1.20678002
57MP0003646_muscle_fatigue1.19056028
58MP0004130_abnormal_muscle_cell1.18479323
59MP0003183_abnormal_peptide_metabolism1.17933251
60MP0002078_abnormal_glucose_homeostasis1.17287495
61MP0004510_myositis1.12165256
62MP0001348_abnormal_lacrimal_gland1.11689225
63MP0002106_abnormal_muscle_physiology1.11666833
64MP0001270_distended_abdomen1.10593520
65MP0005595_abnormal_vascular_smooth1.10480057
66MP0004215_abnormal_myocardial_fiber1.09185848
67MP0001958_emphysema1.08825306
68MP0004134_abnormal_chest_morphology1.08602080
69MP0003091_abnormal_cell_migration1.08167212
70MP0005369_muscle_phenotype1.06984052
71MP0004858_abnormal_nervous_system1.05685474
72MP0004484_altered_response_of1.05470417
73MP0005379_endocrine/exocrine_gland_phen1.04922348
74MP0008961_abnormal_basal_metabolism1.04409344
75MP0002972_abnormal_cardiac_muscle1.04120851
76MP0001879_abnormal_lymphatic_vessel1.03562187
77MP0008775_abnormal_heart_ventricle1.03444238
78MP0005666_abnormal_adipose_tissue1.01366671
79MP0001849_ear_inflammation1.00084165
80MP0000759_abnormal_skeletal_muscle0.99456281
81MP0002295_abnormal_pulmonary_circulatio0.98243620
82MP0000015_abnormal_ear_pigmentation0.97666223
83MP0001542_abnormal_bone_strength0.97377047
84MP0000371_diluted_coat_color0.96681763
85MP0005330_cardiomyopathy0.96262913
86MP0000733_abnormal_muscle_development0.95727192
87MP0003453_abnormal_keratinocyte_physiol0.94482267
88MP0005620_abnormal_muscle_contractility0.93009510
89MP0000538_abnormal_urinary_bladder0.92030528
90MP0005385_cardiovascular_system_phenoty0.91461701
91MP0001544_abnormal_cardiovascular_syste0.91461701
92MP0000428_abnormal_craniofacial_morphol0.90374158
93MP0000462_abnormal_digestive_system0.88929063
94MP0005451_abnormal_body_composition0.87039966
95MP0000534_abnormal_ureter_morphology0.86555671
96MP0002060_abnormal_skin_morphology0.86089414
97MP0003935_abnormal_craniofacial_develop0.85496442
98MP0003941_abnormal_skin_development0.84932540
99MP0002998_abnormal_bone_remodeling0.84838234
100MP0003868_abnormal_feces_composition0.84271493
101MP0000767_abnormal_smooth_muscle0.83844649
102MP0003385_abnormal_body_wall0.83140444
103MP0005508_abnormal_skeleton_morphology0.83124100
104MP0001915_intracranial_hemorrhage0.82863443
105MP0004085_abnormal_heartbeat0.82416251
106MP0003172_abnormal_lysosome_physiology0.81146987
107MP0000747_muscle_weakness0.80018448
108MP0003787_abnormal_imprinting0.79700164
109MP0001614_abnormal_blood_vessel0.78633417
110MP0000266_abnormal_heart_morphology0.77098840
111MP0003942_abnormal_urinary_system0.76817638
112MP0005621_abnormal_cell_physiology0.76170514
113MP0002925_abnormal_cardiovascular_devel0.75743183
114MP0005408_hypopigmentation0.75698981
115MP0000678_abnormal_parathyroid_gland0.75500177
116MP0005058_abnormal_lysosome_morphology0.74390060
117MP0005171_absent_coat_pigmentation0.73972526
118MP0002115_abnormal_skeleton_extremities0.73778528
119MP0000432_abnormal_head_morphology0.73699198
120MP0003795_abnormal_bone_structure0.72099958
121MP0000762_abnormal_tongue_morphology0.71743701
122MP0000750_abnormal_muscle_regeneration0.70589511
123MP0002075_abnormal_coat/hair_pigmentati0.70143128
124MP0003191_abnormal_cellular_cholesterol0.69446203
125MP0005083_abnormal_biliary_tract0.68846347
126MP0001873_stomach_inflammation0.67918989
127MP0002166_altered_tumor_susceptibility0.67822950
128MP0002876_abnormal_thyroid_physiology0.67517654
129MP0002089_abnormal_postnatal_growth/wei0.67469263
130* MP0001929_abnormal_gametogenesis0.67442563
131MP0000427_abnormal_hair_cycle0.67428035
132* MP0003698_abnormal_male_reproductive0.66559537
133MP0009250_abnormal_appendicular_skeleto0.65611325
134MP0010678_abnormal_skin_adnexa0.65341016
135MP0002971_abnormal_brown_adipose0.65222164
136MP0004233_abnormal_muscle_weight0.65076806
137MP0000377_abnormal_hair_follicle0.63686782
138MP0004808_abnormal_hematopoietic_stem0.62855981
139MP0009703_decreased_birth_body0.62763219
140MP0005164_abnormal_response_to0.62492174
141MP0005334_abnormal_fat_pad0.62384225
142MP0002933_joint_inflammation0.62290334
143MP0002128_abnormal_blood_circulation0.62086214
144MP0006138_congestive_heart_failure0.61724646
145MP0010771_integument_phenotype0.61692838
146MP0003959_abnormal_lean_body0.61366345
147MP0003890_abnormal_embryonic-extraembry0.59942561
148MP0001765_abnormal_ion_homeostasis0.59715892
149MP0003115_abnormal_respiratory_system0.59543740
150MP0009931_abnormal_skin_appearance0.58324558
151MP0002086_abnormal_extraembryonic_tissu0.57869399
152MP0004185_abnormal_adipocyte_glucose0.57793278

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)3.94209596
2Insulin-resistant diabetes mellitus (HP:0000831)3.69855563
3Hyperglycemia (HP:0003074)3.54416169
4Fragile skin (HP:0001030)3.49876236
5Hypoplastic ischia (HP:0003175)3.49137146
6Vascular tortuosity (HP:0004948)3.41602572
7Arterial tortuosity (HP:0005116)3.28088163
8Soft skin (HP:0000977)3.24142016
9Abnormality of the ischium (HP:0003174)3.23813246
10Premature rupture of membranes (HP:0001788)3.21795143
11Cerebral aneurysm (HP:0004944)3.11940951
12Hyporeflexia of lower limbs (HP:0002600)3.06746142
13Absent frontal sinuses (HP:0002688)3.05471573
14Increased connective tissue (HP:0009025)2.92788130
15Hypoglycemic seizures (HP:0002173)2.89572842
16Broad face (HP:0000283)2.80691101
17Ulnar bowing (HP:0003031)2.80622671
18Genu recurvatum (HP:0002816)2.77634190
19Bell-shaped thorax (HP:0001591)2.63301010
20Follicular hyperkeratosis (HP:0007502)2.62208681
21Bladder diverticulum (HP:0000015)2.60554264
22Osteolytic defects of the phalanges of the hand (HP:0009771)2.60358345
23Osteolytic defects of the hand bones (HP:0009699)2.60358345
24Mildly elevated creatine phosphokinase (HP:0008180)2.60022319
25Protrusio acetabuli (HP:0003179)2.55782313
26Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.54494078
27Bundle branch block (HP:0011710)2.51363971
28Neonatal short-limb short stature (HP:0008921)2.51256724
29Spondylolisthesis (HP:0003302)2.46091892
30Hyperextensible skin (HP:0000974)2.45975689
31Bowel diverticulosis (HP:0005222)2.45699865
32Neoplasm of the adrenal cortex (HP:0100641)2.45044365
33Aortic regurgitation (HP:0001659)2.44979639
34Type 1 muscle fiber predominance (HP:0003803)2.42658508
35Sudden death (HP:0001699)2.40967892
36Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.38001199
37Exercise-induced myalgia (HP:0003738)2.37459862
38Broad metatarsal (HP:0001783)2.37063804
39Pancreatic islet-cell hyperplasia (HP:0004510)2.33438745
40Atrophic scars (HP:0001075)2.31971689
41Hyperkalemia (HP:0002153)2.31641532
42Hypoglycemic coma (HP:0001325)2.30864711
43Muscle fiber splitting (HP:0003555)2.30611347
44Distal lower limb amyotrophy (HP:0008944)2.30253948
45Shallow orbits (HP:0000586)2.26142207
46Aneurysm (HP:0002617)2.25502130
47Symptomatic seizures (HP:0011145)2.25251539
48Thin bony cortex (HP:0002753)2.21822830
49Cervical subluxation (HP:0003308)2.21608260
50Large for gestational age (HP:0001520)2.19010358
51Right ventricular cardiomyopathy (HP:0011663)2.17410027
52Mitral regurgitation (HP:0001653)2.16118921
53Short nail (HP:0001799)2.16027947
54Cardiovascular calcification (HP:0011915)2.12372551
55Calf muscle hypertrophy (HP:0008981)2.12245935
56Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.09519531
57Asymmetric septal hypertrophy (HP:0001670)2.09174287
58Prominent metopic ridge (HP:0005487)2.09052365
59Dislocated radial head (HP:0003083)2.08945382
60Asymmetry of the thorax (HP:0001555)2.07922211
61Ankle contracture (HP:0006466)2.06865408
62Tibial bowing (HP:0002982)2.06863480
63Natal tooth (HP:0000695)2.06570928
64Subacute progressive viral hepatitis (HP:0006572)2.06258349
65Biconcave vertebral bodies (HP:0004586)2.05909808
66Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.05301593
67Sparse lateral eyebrow (HP:0005338)2.04424413
68Disproportionate tall stature (HP:0001519)2.03730032
69Abnormal delivery (HP:0001787)2.03281651
70Abnormality of oral frenula (HP:0000190)2.03016495
71Abnormality of the calf musculature (HP:0001430)2.02680770
72Difficulty climbing stairs (HP:0003551)2.02493863
73Distal lower limb muscle weakness (HP:0009053)2.01673934
74Persistence of primary teeth (HP:0006335)2.01051787
75Renovascular hypertension (HP:0100817)2.00822197
76Progressive sensorineural hearing impairment (HP:0000408)2.00627096
77Abnormality of endocrine pancreas physiology (HP:0012093)2.00018660
78Abnormality of the pancreatic islet cells (HP:0006476)2.00018660
79Lower limb amyotrophy (HP:0007210)1.98515247
80Abnormality of the radial head (HP:0003995)1.98492226
81Elfin facies (HP:0004428)1.97343577
82Congenital glaucoma (HP:0001087)1.95448446
83Hyperacusis (HP:0010780)1.95437755
84Wrist flexion contracture (HP:0001239)1.94977517
85Peritonitis (HP:0002586)1.94475826
86Subaortic stenosis (HP:0001682)1.93860807
87Abnormality of the left ventricular outflow tract (HP:0011103)1.93860807
88Unilateral renal agenesis (HP:0000122)1.92942059
89Abnormality of the frontal sinuses (HP:0002687)1.92468251
90Wide anterior fontanel (HP:0000260)1.92406048
91Infantile muscular hypotonia (HP:0008947)1.91005463
92Long toe (HP:0010511)1.90926149
93Dilatation of the ascending aorta (HP:0005111)1.90423437
94Abnormality of the metopic suture (HP:0005556)1.90300921
95Flat acetabular roof (HP:0003180)1.89952069
96Wormian bones (HP:0002645)1.89859782
97Hypoplasia of the iris (HP:0007676)1.89531280
98Advanced eruption of teeth (HP:0006288)1.89475497
99Elbow flexion contracture (HP:0002987)1.88751900
100Abnormality of dentin (HP:0010299)1.88045399
101Papillary thyroid carcinoma (HP:0002895)1.87459224
102Difficulty running (HP:0009046)1.86220415
103Spinal rigidity (HP:0003306)1.85727679
104Turricephaly (HP:0000262)1.85239019
105Mitral stenosis (HP:0001718)1.84303727
106Myoglobinuria (HP:0002913)1.83847272
107Narrow palate (HP:0000189)1.83435470
108Bowing of the arm (HP:0006488)1.82582132
109Bowed forearm bones (HP:0003956)1.82582132
110Vertebral compression fractures (HP:0002953)1.81528569
111Macroorchidism (HP:0000053)1.80991874
112Osteoarthritis (HP:0002758)1.80147284
113Dysmetric saccades (HP:0000641)1.79956779
114Aortic dissection (HP:0002647)1.79607300
115Muscle hypertrophy of the lower extremities (HP:0008968)1.79271474
116Increased variability in muscle fiber diameter (HP:0003557)1.76144711
117Spinal cord compression (HP:0002176)1.74946379
118Exercise-induced muscle cramps (HP:0003710)1.73705955
119Abnormality of the acetabulum (HP:0003170)1.73612978
120Abnormality of carpal bone ossification (HP:0006257)1.72691096
121Hypoplasia of the fovea (HP:0007750)1.72535418
122Aplasia/Hypoplasia of the fovea (HP:0008060)1.72535418
123Flat cornea (HP:0007720)1.71269177
124Long eyelashes (HP:0000527)1.70630692
125Scapular winging (HP:0003691)1.70573637
126Ankyloglossia (HP:0010296)1.70260138
127Radial bowing (HP:0002986)1.70007341
128Absent/shortened dynein arms (HP:0200106)1.68749056
129Dynein arm defect of respiratory motile cilia (HP:0012255)1.68749056
130Mitral valve prolapse (HP:0001634)1.68232794
131Aortic aneurysm (HP:0004942)1.68051836
132Obstructive sleep apnea (HP:0002870)1.67656605
133Ovoid vertebral bodies (HP:0003300)1.67004318
134Ketoacidosis (HP:0001993)1.66036260
135Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.65997074
136Cystic liver disease (HP:0006706)1.65896025
137Prolonged QT interval (HP:0001657)1.65384402
138Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.65184107
139Hand muscle atrophy (HP:0009130)1.64847140
140Atrial fibrillation (HP:0005110)1.64815865
141Abnormal ossification of hand bones (HP:0005921)1.64538161
142Mild short stature (HP:0003502)1.64333611
143Buphthalmos (HP:0000557)1.63589042
144Joint laxity (HP:0001388)1.63577031
145Round ear (HP:0100830)1.63460161
146Ventricular tachycardia (HP:0004756)1.63347694
147Lymphangioma (HP:0100764)1.63162388
148Coxa vara (HP:0002812)1.62767620
149Overgrowth (HP:0001548)1.62725453
150Male infertility (HP:0003251)1.62656536
151EMG: myopathic abnormalities (HP:0003458)1.60951403
152Heterotopia (HP:0002282)1.60459811
153Mucopolysacchariduria (HP:0008155)1.59725418
154Urinary glycosaminoglycan excretion (HP:0003541)1.59725418
155Breech presentation (HP:0001623)1.59411993
156Aortic valve stenosis (HP:0001650)1.59130934
157Epiphyseal dysplasia (HP:0002656)1.58654544
158Upper limb amyotrophy (HP:0009129)1.58371643
159Distal upper limb amyotrophy (HP:0007149)1.58371643
160Blue sclerae (HP:0000592)1.56639723
161Aplasia/Hypoplasia of the macula (HP:0008059)1.55583423
162Aplasia/Hypoplasia affecting the retina (HP:0008061)1.54899884

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.81507449
2EEF2K3.78600095
3IRAK33.29077606
4EPHA32.80856864
5TTN2.80250087
6ZAK2.71680337
7LATS12.56702975
8PDK42.27600347
9PDK32.27600347
10MAPKAPK32.21140988
11MET2.11766000
12FRK1.99265537
13PRKD31.98162249
14EPHA21.95841900
15LMTK21.87005418
16PDGFRA1.83589798
17MST1R1.81467118
18PDK21.63674573
19TAOK31.63359219
20PAK21.62799971
21TRIB31.56400272
22MYLK1.55105046
23JAK11.54683171
24WNK11.53278795
25EPHB11.49593537
26OBSCN1.48195800
27SMG11.46982836
28STK38L1.46291552
29DDR21.44344804
30CDC42BPA1.43468146
31SIK11.43116254
32PTK61.41177506
33RIPK11.41146788
34DMPK1.38891990
35BRD41.34196606
36WNK41.33789699
37IRAK11.32339997
38MAP3K21.28676617
39SGK31.28599376
40CAMK1G1.28447604
41CDK121.28137116
42CAMK1D1.26891521
43AKT31.23443566
44MAPK111.21819766
45SGK21.16926880
46NUAK11.15685573
47FER1.14135606
48STK31.08714116
49PRKCH1.07437102
50MELK1.05731957
51PKN21.05291469
52HIPK21.05221364
53PAK31.05138821
54SCYL21.03916941
55PASK1.03480967
56PIK3CG1.03370480
57STK380.98480808
58ERBB30.96086237
59MAP3K70.95285994
60MAP3K140.94859496
61MTOR0.93847112
62FGFR30.91467955
63FGFR40.90673680
64NEK90.90168309
65PDGFRB0.88547213
66MAP3K130.88018156
67ACVR1B0.85523057
68TESK10.83828943
69PAK40.82894198
70ICK0.82016657
71TRPM70.81856202
72FLT30.81143793
73MAP2K10.80435405
74PDPK10.80163836
75PRKAA10.80089289
76MAP3K30.79348530
77PRPF4B0.77063314
78IRAK40.77060067
79KSR20.76353053
80NTRK10.76312048
81ERBB40.75242763
82PTK2B0.74220735
83CAMKK20.72875399
84IRAK20.72850769
85PIK3CA0.71637465
86PAK60.70746445
87ERN10.70529921
88RET0.70460653
89MARK20.70158545
90PHKG20.66590964
91PHKG10.66590964
92MARK10.66562860
93CHUK0.64442069
94SGK2230.64223364
95SGK4940.64223364
96FGFR20.62929833
97CAMKK10.62922494
98PRKD10.62406683
99MUSK0.62226958
100STK240.62204873
101KSR10.62023293
102PTK20.61408764
103RPS6KB20.59707549
104SGK10.56777158
105ILK0.56074454
106EPHB20.55887437
107JAK30.55064289
108TGFBR20.54751176
109PRKD20.53748864
110BMX0.52748485
111RPS6KA20.52662529
112ROCK10.52618632
113ALK0.52341682
114CAMK2D0.51695231
115RAF10.47929407
116DYRK1B0.47794525
117GSK3A0.47020183
118PRKCI0.46746354
119BMPR20.43702871
120PDK10.43508279
121MAP3K100.43281846
122PRKCE0.43132880
123PLK20.40932264
124NEK60.40768551
125RPS6KB10.38923660
126MAP3K90.38780757
127PRKAA20.37902896
128BRSK20.37307487
129ATM0.37305968
130EIF2AK30.36535370
131MAPK70.35310614
132MAP3K10.34867532
133TTK0.34146150
134PRKDC0.33163140
135FGFR10.32696970
136ROCK20.32154971
137JAK20.31916566
138PIM20.31679535
139STK390.31355258
140MAPK10.30880460
141NTRK30.29952065
142MAPK140.27988680
143LATS20.27516330

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.15817743
2Type II diabetes mellitus_Homo sapiens_hsa049302.56970609
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.22256129
4Dilated cardiomyopathy_Homo sapiens_hsa054141.99133528
5Insulin secretion_Homo sapiens_hsa049111.98685302
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.90483343
7ECM-receptor interaction_Homo sapiens_hsa045121.76709099
8Dorso-ventral axis formation_Homo sapiens_hsa043201.68234342
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.64339349
10Other glycan degradation_Homo sapiens_hsa005111.61380210
11Focal adhesion_Homo sapiens_hsa045101.55190302
12Insulin resistance_Homo sapiens_hsa049311.50104161
13Glucagon signaling pathway_Homo sapiens_hsa049221.49329245
14Protein digestion and absorption_Homo sapiens_hsa049741.41910722
15Lysine degradation_Homo sapiens_hsa003101.39583313
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39241335
17Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.39183566
18Carbohydrate digestion and absorption_Homo sapiens_hsa049731.35858589
19Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.25183478
20Selenocompound metabolism_Homo sapiens_hsa004501.22595256
21VEGF signaling pathway_Homo sapiens_hsa043701.22495907
22Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18960355
23mTOR signaling pathway_Homo sapiens_hsa041501.17887003
24Type I diabetes mellitus_Homo sapiens_hsa049401.17345444
25Adherens junction_Homo sapiens_hsa045201.15424936
26Bladder cancer_Homo sapiens_hsa052191.15172141
27ErbB signaling pathway_Homo sapiens_hsa040121.12429873
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07158143
29Amoebiasis_Homo sapiens_hsa051461.07015049
30Longevity regulating pathway - mammal_Homo sapiens_hsa042111.06137262
31Non-small cell lung cancer_Homo sapiens_hsa052231.05975314
32Sulfur metabolism_Homo sapiens_hsa009201.04780955
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03725735
34GnRH signaling pathway_Homo sapiens_hsa049121.02500452
35Prostate cancer_Homo sapiens_hsa052151.02427634
36Thyroid cancer_Homo sapiens_hsa052161.01515699
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01031868
38Prolactin signaling pathway_Homo sapiens_hsa049170.97567142
39AMPK signaling pathway_Homo sapiens_hsa041520.96039313
40Toxoplasmosis_Homo sapiens_hsa051450.95074655
41Estrogen signaling pathway_Homo sapiens_hsa049150.94733013
42Melanoma_Homo sapiens_hsa052180.94562254
43Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94098570
44Starch and sucrose metabolism_Homo sapiens_hsa005000.92321287
45Phospholipase D signaling pathway_Homo sapiens_hsa040720.92268859
46Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92050965
47Insulin signaling pathway_Homo sapiens_hsa049100.91820108
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90478302
49Pancreatic secretion_Homo sapiens_hsa049720.89623597
50Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89435559
51Adipocytokine signaling pathway_Homo sapiens_hsa049200.88899558
52Proteoglycans in cancer_Homo sapiens_hsa052050.88555684
53ABC transporters_Homo sapiens_hsa020100.87271490
54Acute myeloid leukemia_Homo sapiens_hsa052210.87169812
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86218502
56N-Glycan biosynthesis_Homo sapiens_hsa005100.86023190
57Protein export_Homo sapiens_hsa030600.85920621
58Amphetamine addiction_Homo sapiens_hsa050310.84740247
59FoxO signaling pathway_Homo sapiens_hsa040680.81157271
60Small cell lung cancer_Homo sapiens_hsa052220.80828340
61Choline metabolism in cancer_Homo sapiens_hsa052310.79601720
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78900802
63Renin secretion_Homo sapiens_hsa049240.78027482
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77678605
65TNF signaling pathway_Homo sapiens_hsa046680.76082872
66Hippo signaling pathway_Homo sapiens_hsa043900.75264154
67TGF-beta signaling pathway_Homo sapiens_hsa043500.75126147
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.72827016
69Notch signaling pathway_Homo sapiens_hsa043300.72251424
70Circadian rhythm_Homo sapiens_hsa047100.71966179
71Pathways in cancer_Homo sapiens_hsa052000.71679255
72Thyroid hormone synthesis_Homo sapiens_hsa049180.71378256
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.71244820
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.70709236
75Glioma_Homo sapiens_hsa052140.70170063
76Fructose and mannose metabolism_Homo sapiens_hsa000510.70100873
77Cholinergic synapse_Homo sapiens_hsa047250.70057490
78Taste transduction_Homo sapiens_hsa047420.69220344
79Melanogenesis_Homo sapiens_hsa049160.68541625
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68212915
81Viral myocarditis_Homo sapiens_hsa054160.67462035
82Lysosome_Homo sapiens_hsa041420.66938603
83Vitamin B6 metabolism_Homo sapiens_hsa007500.66768807
84Chronic myeloid leukemia_Homo sapiens_hsa052200.66621538
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66409193
86Cocaine addiction_Homo sapiens_hsa050300.65869837
87Rap1 signaling pathway_Homo sapiens_hsa040150.64693143
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63505734
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62249998
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61885752
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.61838238
92Endometrial cancer_Homo sapiens_hsa052130.61625249
93Osteoclast differentiation_Homo sapiens_hsa043800.61086850
94Long-term potentiation_Homo sapiens_hsa047200.60785416
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60276577
96cAMP signaling pathway_Homo sapiens_hsa040240.59487658
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58688587
98MicroRNAs in cancer_Homo sapiens_hsa052060.57401710
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57032483
100Axon guidance_Homo sapiens_hsa043600.57005598
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.56544999
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55988157
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55744109
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55175830
105Circadian entrainment_Homo sapiens_hsa047130.54994776
106Hepatitis C_Homo sapiens_hsa051600.54888095
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53622123
108Oxytocin signaling pathway_Homo sapiens_hsa049210.53291021
109MAPK signaling pathway_Homo sapiens_hsa040100.52347935
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52323969
111Pancreatic cancer_Homo sapiens_hsa052120.52304136
112Leishmaniasis_Homo sapiens_hsa051400.51916707
113Measles_Homo sapiens_hsa051620.51213673
114Fatty acid biosynthesis_Homo sapiens_hsa000610.50896055
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.50612583
116Vibrio cholerae infection_Homo sapiens_hsa051100.49254393
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49231631
118NF-kappa B signaling pathway_Homo sapiens_hsa040640.48802853
119Influenza A_Homo sapiens_hsa051640.48419197
120Renal cell carcinoma_Homo sapiens_hsa052110.47265269
121Phagosome_Homo sapiens_hsa041450.46628938
122Prion diseases_Homo sapiens_hsa050200.45595611
123Legionellosis_Homo sapiens_hsa051340.45217974
124Inositol phosphate metabolism_Homo sapiens_hsa005620.44315387
125Endocytosis_Homo sapiens_hsa041440.43727257
126HIF-1 signaling pathway_Homo sapiens_hsa040660.42733746
127Tight junction_Homo sapiens_hsa045300.42629491
128Ovarian steroidogenesis_Homo sapiens_hsa049130.42493165
129Platelet activation_Homo sapiens_hsa046110.41932227
130Sphingolipid metabolism_Homo sapiens_hsa006000.41683383
131Propanoate metabolism_Homo sapiens_hsa006400.41458330

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