GNRH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted peptide hormone and member of the gonadotropin-releasing hormone (GnRH) family of proteins. The encoded protein regulates reproductive function by stimulating the production and release of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The encoded protein may inhibit endometrial, ovarian, prostate, and breast cancer cell proliferation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cholesterol efflux (GO:0033344)9.27324729
2protein-lipid complex remodeling (GO:0034368)9.05367915
3macromolecular complex remodeling (GO:0034367)9.05367915
4plasma lipoprotein particle remodeling (GO:0034369)9.05367915
5negative regulation of lipase activity (GO:0060192)8.07712151
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)7.79433975
7negative regulation of sterol transport (GO:0032372)7.75398026
8negative regulation of cholesterol transport (GO:0032375)7.75398026
9negative regulation of fatty acid biosynthetic process (GO:0045717)7.21696275
10plasma lipoprotein particle organization (GO:0071827)7.05794840
11plasma lipoprotein particle clearance (GO:0034381)6.98674164
12protein-lipid complex subunit organization (GO:0071825)6.71991903
13lipoprotein transport (GO:0042953)6.62036113
14positive regulation of triglyceride lipase activity (GO:0061365)6.58983826
15positive regulation of lipoprotein lipase activity (GO:0051006)6.58983826
16regulation of lipoprotein metabolic process (GO:0050746)6.56608666
17regulation of lipoprotein particle clearance (GO:0010984)5.93310696
18ovulation from ovarian follicle (GO:0001542)5.86056993
19protein carboxylation (GO:0018214)5.68715224
20peptidyl-glutamic acid carboxylation (GO:0017187)5.68715224
21cellular response to zinc ion (GO:0071294)5.56442141
22transepithelial transport (GO:0070633)5.53913027
23regulation of triglyceride metabolic process (GO:0090207)5.42722444
24sterol transport (GO:0015918)5.06438990
25cholesterol transport (GO:0030301)5.06438990
26positive regulation of lipid catabolic process (GO:0050996)5.04633292
27negative regulation of lipid catabolic process (GO:0050995)5.04250510
28polyol transport (GO:0015791)4.95872819
29acylglycerol homeostasis (GO:0055090)4.85765122
30triglyceride homeostasis (GO:0070328)4.85765122
31lipoprotein metabolic process (GO:0042157)4.69335215
32negative regulation of receptor-mediated endocytosis (GO:0048261)4.67017334
33cellular response to oxygen radical (GO:0071450)4.60672430
34removal of superoxide radicals (GO:0019430)4.60672430
35cellular response to superoxide (GO:0071451)4.60672430
36acylglycerol catabolic process (GO:0046464)4.59748210
37neutral lipid catabolic process (GO:0046461)4.59748210
38regulation of sterol transport (GO:0032371)4.55655856
39regulation of cholesterol transport (GO:0032374)4.55655856
40regulation of fatty acid biosynthetic process (GO:0042304)4.43687423
41response to phenylpropanoid (GO:0080184)4.26520005
42glial cell proliferation (GO:0014009)4.23459287
43positive regulation of triglyceride metabolic process (GO:0090208)4.17289045
44regulation of lipoprotein lipase activity (GO:0051004)4.11866136
45cholesterol homeostasis (GO:0042632)4.08939712
46triglyceride catabolic process (GO:0019433)4.06821588
47regulation of lipid catabolic process (GO:0050994)4.04291287
48sterol homeostasis (GO:0055092)4.01796461
49regulation of cytokine secretion involved in immune response (GO:0002739)4.00361885
50glutamine family amino acid biosynthetic process (GO:0009084)3.89192496
51positive regulation of fatty acid biosynthetic process (GO:0045723)3.86248300
52sperm capacitation (GO:0048240)3.85792192
53negative regulation of fatty acid metabolic process (GO:0045922)3.83184075
54progesterone metabolic process (GO:0042448)3.81091085
55L-ascorbic acid metabolic process (GO:0019852)3.76901539
56positive regulation of steroid metabolic process (GO:0045940)3.74055553
57DNA damage response, detection of DNA damage (GO:0042769)3.73297971
58glycerolipid catabolic process (GO:0046503)3.64792011
59protein kinase C signaling (GO:0070528)3.63279724
60phototransduction, visible light (GO:0007603)3.59921103
61sulfate transmembrane transport (GO:1902358)3.58483379
62retinoid metabolic process (GO:0001523)3.56751358
63homocysteine metabolic process (GO:0050667)3.53438931
64response to superoxide (GO:0000303)3.49487742
65regulation of digestive system process (GO:0044058)3.47917224
66response to hydroperoxide (GO:0033194)3.41985417
67positive regulation of insulin receptor signaling pathway (GO:0046628)3.37338274
68peptide biosynthetic process (GO:0043043)3.33112751
69negative regulation of gluconeogenesis (GO:0045721)3.32692920
70SMAD protein signal transduction (GO:0060395)3.31152795
71diterpenoid metabolic process (GO:0016101)3.29412990
72vitamin A metabolic process (GO:0006776)3.28798621
73phospholipid transport (GO:0015914)3.26402921
74myelination in peripheral nervous system (GO:0022011)3.24383930
75peripheral nervous system axon ensheathment (GO:0032292)3.24383930
76response to oxygen radical (GO:0000305)3.23900439
77bile acid and bile salt transport (GO:0015721)3.17329332
78negative regulation of lipid transport (GO:0032369)3.12488271
79regulation of Rho protein signal transduction (GO:0035023)3.11778161
80phospholipid homeostasis (GO:0055091)3.11380451
81positive regulation of Rho protein signal transduction (GO:0035025)3.11053961
82phototransduction (GO:0007602)3.10365605
83detection of visible light (GO:0009584)3.07152026
84water-soluble vitamin biosynthetic process (GO:0042364)2.99884098
85oligosaccharide catabolic process (GO:0009313)2.98968931
86sulfate transport (GO:0008272)2.98280547
87hydrogen peroxide catabolic process (GO:0042744)2.97889076
88organic hydroxy compound transport (GO:0015850)2.92789278
89vitamin D metabolic process (GO:0042359)2.89762693
90positive regulation of glycoprotein biosynthetic process (GO:0010560)2.89721937
91terpenoid metabolic process (GO:0006721)2.89170164
92sulfation (GO:0051923)2.89153292
93phospholipid efflux (GO:0033700)14.9537690
94high-density lipoprotein particle remodeling (GO:0034375)14.3167899
95regulation of triglyceride catabolic process (GO:0010896)13.3835115
96reverse cholesterol transport (GO:0043691)12.2680613
97plasma lipoprotein particle assembly (GO:0034377)12.0342416
98very-low-density lipoprotein particle assembly (GO:0034379)11.0735801
99protein-lipid complex assembly (GO:0065005)10.8615996
100regulation of cholesterol esterification (GO:0010872)10.4676677

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human6.74072683
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.27345431
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse5.12185940
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.04424282
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.65209432
6HNF4A_19761587_ChIP-ChIP_CACO-2_Human4.22645557
7CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.81932310
8IKZF1_21737484_ChIP-ChIP_HCT116_Human3.35844900
9EGR1_23403033_ChIP-Seq_LIVER_Mouse3.28978760
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.23105331
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.86333098
12EZH2_22144423_ChIP-Seq_EOC_Human2.66340123
13SRY_22984422_ChIP-ChIP_TESTIS_Rat2.56772698
14CDX2_20551321_ChIP-Seq_CACO-2_Human2.40368944
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.35197544
16LXR_22158963_ChIP-Seq_LIVER_Mouse2.33258057
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.26558680
18TP53_16413492_ChIP-PET_HCT116_Human2.09335626
19SALL4_18804426_ChIP-ChIP_XEN_Mouse1.85092606
20HNF4A_19822575_ChIP-Seq_HepG2_Human1.73519116
21FOXA2_19822575_ChIP-Seq_HepG2_Human1.72567655
22PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.63422856
23FOXH1_21741376_ChIP-Seq_EPCs_Human1.62924496
24PPARA_22158963_ChIP-Seq_LIVER_Mouse1.59233080
25PPAR_26484153_Chip-Seq_NCI-H1993_Human1.57992252
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54930460
27CTCF_27219007_Chip-Seq_Bcells_Human1.48288876
28NANOG_20526341_ChIP-Seq_ESCs_Human1.42444403
29SOX2_22085726_ChIP-Seq_NPCs_Mouse1.36954081
30VDR_22108803_ChIP-Seq_LS180_Human1.34894426
31GATA6_25053715_ChIP-Seq_YYC3_Human1.31153559
32CEBPB_22108803_ChIP-Seq_LS180_Human1.30396218
33SMAD3_21741376_ChIP-Seq_HESCs_Human1.30259593
34FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24340151
35FOXA1_25329375_ChIP-Seq_VCAP_Human1.24340151
36JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.24192237
37BCAT_22108803_ChIP-Seq_LS180_Human1.20406988
38SMAD4_21741376_ChIP-Seq_HESCs_Human1.20304750
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17340540
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15476545
41TP53_18474530_ChIP-ChIP_U2OS_Human1.15348265
42P68_20966046_ChIP-Seq_HELA_Human1.11882255
43ELF1_20517297_ChIP-Seq_JURKAT_Human1.11846347
44VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11614187
45AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.11390518
46ESR1_20079471_ChIP-ChIP_T-47D_Human1.10359801
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09572204
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.09323656
49CTCF_20526341_ChIP-Seq_ESCs_Human1.09009648
50P300_27268052_Chip-Seq_Bcells_Human1.06565831
51GATA4_25053715_ChIP-Seq_YYC3_Human1.05923265
52NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99883012
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99783233
54EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98413169
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97065620
56SMRT_27268052_Chip-Seq_Bcells_Human0.96910982
57CDX2_22108803_ChIP-Seq_LS180_Human0.96592089
58ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95253615
59SOX2_20726797_ChIP-Seq_SW620_Human0.93860958
60ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93331794
61GATA3_21878914_ChIP-Seq_MCF-7_Human0.93223322
62SA1_27219007_Chip-Seq_Bcells_Human0.92420628
63CBP_21632823_ChIP-Seq_H3396_Human0.91748319
64E2F1_20622854_ChIP-Seq_HELA_Human0.91347480
65IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.87223139
66NCOR_22424771_ChIP-Seq_293T_Human0.85477803
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85293667
68CBP_20019798_ChIP-Seq_JUKART_Human0.85293667
69CTCF_27219007_Chip-Seq_ERYTHROID_Human0.84635336
70CTCF_21964334_Chip-Seq_Bcells_Human0.83878592
71AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83082913
72MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.82979640
73* FOXA1_25552417_ChIP-Seq_VCAP_Human0.82310801
74FOXH1_21741376_ChIP-Seq_ESCs_Human0.82203442
75PHF8_20622853_ChIP-Seq_HELA_Human0.82041831
76RAC3_21632823_ChIP-Seq_H3396_Human0.80736009
77CDX2_19796622_ChIP-Seq_MESCs_Mouse0.79090944
78PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.78148998
79RXR_22108803_ChIP-Seq_LS180_Human0.76741381
80RBPJ_21746931_ChIP-Seq_IB4_Human0.76033510
81KLF5_20875108_ChIP-Seq_MESCs_Mouse0.75954113
82RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75911880
83* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.75330897
84FOXA1_21572438_ChIP-Seq_LNCaP_Human0.74698837
85* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.74177762
86TDRD3_21172665_ChIP-Seq_MCF-7_Human0.73606931
87CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.73524021
88RUNX_20019798_ChIP-Seq_JUKART_Human0.73052094
89ETV1_20927104_ChIP-Seq_GIST48_Human0.72814601
90RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.72359791
91EGR1_19032775_ChIP-ChIP_M12_Human0.72100492
92CTNNB1_20460455_ChIP-Seq_HCT116_Human0.71371568
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71299568
94PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.70684693
95CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.70524376
96SUZ12_27294783_Chip-Seq_NPCs_Mouse0.69499526
97TAF2_19829295_ChIP-Seq_ESCs_Human0.69276840
98KAP1_22055183_ChIP-Seq_ESCs_Mouse0.69057945
99WDR5_24793694_ChIP-Seq_LNCAP_Human0.68670860
100CBX2_22325352_ChIP-Seq_293T-Rex_Human0.67219469

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.30525862
2MP0004270_analgesia4.49825945
3MP0005377_hearing/vestibular/ear_phenot3.33973931
4MP0003878_abnormal_ear_physiology3.33973931
5MP0010329_abnormal_lipoprotein_level3.04308044
6MP0002876_abnormal_thyroid_physiology2.82136983
7MP0004019_abnormal_vitamin_homeostasis2.67554212
8MP0004145_abnormal_muscle_electrophysio2.29482941
9MP0002254_reproductive_system_inflammat2.20454154
10MP0003191_abnormal_cellular_cholesterol2.10954087
11MP0009840_abnormal_foam_cell14.6584794
12MP0002822_catalepsy1.91220327
13MP0005332_abnormal_amino_acid1.69470791
14MP0001666_abnormal_nutrient_absorption1.63654508
15MP0003136_yellow_coat_color1.54398586
16MP0002734_abnormal_mechanical_nocicepti1.47468476
17MP0004233_abnormal_muscle_weight1.43656259
18MP0000372_irregular_coat_pigmentation1.36341307
19MP0005551_abnormal_eye_electrophysiolog1.27691658
20MP0006072_abnormal_retinal_apoptosis1.26658161
21MP0004142_abnormal_muscle_tone1.24846782
22MP0005409_darkened_coat_color1.19835996
23MP0009643_abnormal_urine_homeostasis1.17702140
24MP0003690_abnormal_glial_cell1.16640527
25MP0003718_maternal_effect1.16316038
26MP0005171_absent_coat_pigmentation1.13562287
27MP0004264_abnormal_extraembryonic_tissu1.12334922
28MP0002295_abnormal_pulmonary_circulatio1.04719034
29MP0001958_emphysema1.03074196
30MP0000566_synostosis0.99683620
31MP0004147_increased_porphyrin_level0.92719787
32MP0005367_renal/urinary_system_phenotyp0.92536780
33MP0000516_abnormal_urinary_system0.92536780
34MP0005365_abnormal_bile_salt0.91357641
35MP0002909_abnormal_adrenal_gland0.89446667
36MP0002118_abnormal_lipid_homeostasis0.87924063
37MP0000604_amyloidosis0.85558553
38MP0005636_abnormal_mineral_homeostasis0.84760167
39MP0002557_abnormal_social/conspecific_i0.84625134
40MP0000249_abnormal_blood_vessel0.81369340
41MP0005164_abnormal_response_to0.79140117
42MP0005448_abnormal_energy_balance0.77914634
43MP0005058_abnormal_lysosome_morphology0.76029194
44MP0002090_abnormal_vision0.74277535
45MP0001919_abnormal_reproductive_system0.74258444
46MP0001485_abnormal_pinna_reflex0.72839584
47MP0008875_abnormal_xenobiotic_pharmacok0.70854994
48MP0005389_reproductive_system_phenotype0.68239332
49MP0000920_abnormal_myelination0.65806270
50MP0005085_abnormal_gallbladder_physiolo0.63057331
51MP0003632_abnormal_nervous_system0.60901126
52MP0000003_abnormal_adipose_tissue0.60000202
53MP0000639_abnormal_adrenal_gland0.59808681
54MP0009642_abnormal_blood_homeostasis0.57096022
55MP0004883_abnormal_blood_vessel0.56712025
56MP0001756_abnormal_urination0.52999773
57MP0001188_hyperpigmentation0.52399530
58MP0001299_abnormal_eye_distance/0.52188824
59MP0006082_CNS_inflammation0.51884805
60MP0002139_abnormal_hepatobiliary_system0.51430383
61MP0003186_abnormal_redox_activity0.50811027
62MP0001293_anophthalmia0.49395767
63MP0001177_atelectasis0.49138396
64MP0005584_abnormal_enzyme/coenzyme_acti0.47857160
65MP0003879_abnormal_hair_cell0.45565575
66MP0001119_abnormal_female_reproductive0.44813126
67MP0008569_lethality_at_weaning0.43863111
68MP0005257_abnormal_intraocular_pressure0.43258132
69MP0009115_abnormal_fat_cell0.43250516
70MP0001765_abnormal_ion_homeostasis0.41992694
71MP0001663_abnormal_digestive_system0.40942597
72MP0003953_abnormal_hormone_level0.40871521
73MP0010030_abnormal_orbit_morphology0.40702544
74MP0002136_abnormal_kidney_physiology0.40597830
75MP0002160_abnormal_reproductive_system0.39652964
76MP0005464_abnormal_platelet_physiology0.39359464
77MP0000427_abnormal_hair_cycle0.38191740
78MP0002638_abnormal_pupillary_reflex0.37858359
79MP0001986_abnormal_taste_sensitivity0.37656893
80MP0005395_other_phenotype0.35929220
81MP0002877_abnormal_melanocyte_morpholog0.35385284
82MP0000609_abnormal_liver_physiology0.35339848
83MP0003123_paternal_imprinting0.35243049
84MP0001324_abnormal_eye_pigmentation0.34633067
85MP0002970_abnormal_white_adipose0.33662614
86MP0002069_abnormal_eating/drinking_beha0.32902737
87MP0004043_abnormal_pH_regulation0.32053962
88MP0003638_abnormal_response/metabolism_0.31425182
89MP0002089_abnormal_postnatal_growth/wei0.31304408
90MP0005670_abnormal_white_adipose0.30943796
91MP0003646_muscle_fatigue0.30863017
92MP0003634_abnormal_glial_cell0.30179349
93MP0005381_digestive/alimentary_phenotyp0.29061544
94MP0005408_hypopigmentation0.28950592
95MP0001529_abnormal_vocalization0.28783190
96MP0002078_abnormal_glucose_homeostasis0.28594573
97MP0000681_abnormal_thyroid_gland0.28245315
98MP0001764_abnormal_homeostasis0.27926224
99MP0003699_abnormal_female_reproductive0.27860367
100MP0005174_abnormal_tail_pigmentation0.27779835

Predicted human phenotypes

RankGene SetZ-score
1Hypolipoproteinemia (HP:0010981)8.43706238
2Malnutrition (HP:0004395)7.94235865
3Abnormality of the level of lipoprotein cholesterol (HP:0010979)6.51047487
4Abnormality of pyrimidine metabolism (HP:0004353)6.04596088
5Pigmentary retinal degeneration (HP:0001146)5.38192124
6Hyperglycinemia (HP:0002154)4.84509474
7Hypomagnesemia (HP:0002917)4.81688531
8Vacuolated lymphocytes (HP:0001922)4.80092885
9Abnormality of macrophages (HP:0004311)4.71254780
10Nausea (HP:0002018)4.69912139
11Joint hemorrhage (HP:0005261)4.58284357
12Abnormality of monocarboxylic acid metabolism (HP:0010996)4.45811241
13Tetany (HP:0001281)4.14514069
14Abnormality of magnesium homeostasis (HP:0004921)4.12889914
15Type 2 muscle fiber atrophy (HP:0003554)4.12588868
16Abnormality of the common coagulation pathway (HP:0010990)3.79669474
17Absent rod-and cone-mediated responses on ERG (HP:0007688)3.76974147
18Hypoplasia of the iris (HP:0007676)3.67711990
19Muscle fiber atrophy (HP:0100295)3.58012202
20Gingival bleeding (HP:0000225)3.53564494
21Congenital sensorineural hearing impairment (HP:0008527)3.41773584
22Vitreoretinal degeneration (HP:0000655)3.33855392
23Deep venous thrombosis (HP:0002625)3.25986026
24Severe visual impairment (HP:0001141)3.23577042
25Increased serum ferritin (HP:0003281)3.15847984
26Proximal tubulopathy (HP:0000114)3.12971162
27Prolonged partial thromboplastin time (HP:0003645)3.10755636
28Abnormality of the nasal septum (HP:0000419)3.02283986
29Spontaneous abortion (HP:0005268)3.01897570
30Hypoalphalipoproteinemia (HP:0003233)2.98758062
31Amyloidosis (HP:0011034)2.94148127
32Abnormality of glycine metabolism (HP:0010895)2.88662548
33Abnormality of serine family amino acid metabolism (HP:0010894)2.88662548
34Dysostosis multiplex (HP:0000943)2.80355313
35Prolonged neonatal jaundice (HP:0006579)2.80215793
36Menorrhagia (HP:0000132)2.78726923
37Abnormal rod and cone electroretinograms (HP:0008323)2.75842030
38Dyschromatopsia (HP:0007641)2.74090602
39Hyperglycinuria (HP:0003108)2.70635043
40Fatigable weakness (HP:0003473)2.70322616
41Abnormality of the neuromuscular junction (HP:0003398)2.70322616
42Truncal obesity (HP:0001956)2.61691145
43Mitral stenosis (HP:0001718)2.60290520
44Retinal atrophy (HP:0001105)2.53762364
45Abnormality of transition element cation homeostasis (HP:0011030)2.51452295
46Severe Myopia (HP:0011003)2.47213315
47Bicornuate uterus (HP:0000813)2.46178209
48Delayed CNS myelination (HP:0002188)2.41738374
49Abnormality of iron homeostasis (HP:0011031)2.38762952
50Arthropathy (HP:0003040)2.38130253
51Abnormality of nucleobase metabolism (HP:0010932)2.35883924
52Dehydration (HP:0001944)2.34618065
53Nonprogressive disorder (HP:0003680)2.34422566
54Hyperammonemia (HP:0001987)2.33377176
55Vascular calcification (HP:0004934)2.31051150
56Stage 5 chronic kidney disease (HP:0003774)2.27616634
57Abnormal pancreas size (HP:0012094)2.27072010
58Late onset (HP:0003584)2.25505608
59Pendular nystagmus (HP:0012043)2.24215444
60Fat malabsorption (HP:0002630)2.19111561
61High anterior hairline (HP:0009890)2.17638179
62Metabolic acidosis (HP:0001942)2.12101832
63Partial agenesis of the corpus callosum (HP:0001338)2.08857462
64Acanthocytosis (HP:0001927)2.07029791
65Choroideremia (HP:0001139)2.01970372
66Cardiovascular calcification (HP:0011915)2.01475782
67Hypobetalipoproteinemia (HP:0003563)14.5600526
68Hyperlipoproteinemia (HP:0010980)10.7036795
69Chronic hepatic failure (HP:0100626)1.99940226
70Weak cry (HP:0001612)1.98610334
71White forelock (HP:0002211)1.98447669
72Abnormality of the phalanges of the 2nd finger (HP:0009541)1.95110455
73Albinism (HP:0001022)1.93820947
74Easy fatigability (HP:0003388)1.88430956
75Abolished electroretinogram (ERG) (HP:0000550)1.82044554
76Decreased muscle mass (HP:0003199)1.81823606
77Microretrognathia (HP:0000308)1.80575219
78Joint swelling (HP:0001386)1.76170114
79Patchy hypopigmentation of hair (HP:0011365)1.74976692
80Short hallux (HP:0010109)1.72109713
81Abnormality of the Achilles tendon (HP:0005109)1.71514556
82Pancreatitis (HP:0001733)1.71275525
83Prenatal maternal abnormality (HP:0002686)1.71045131
84Back pain (HP:0003418)1.69983905
85Abnormality of chloride homeostasis (HP:0011422)1.67636419
86Hepatoblastoma (HP:0002884)1.61156725
87Steatorrhea (HP:0002570)1.59242885
88Intellectual disability, moderate (HP:0002342)1.57825414
89Wide anterior fontanel (HP:0000260)1.57171124
90Rhinitis (HP:0012384)1.56330375
91Abnormality of vitamin B metabolism (HP:0004340)1.56290109
92Macular degeneration (HP:0000608)1.54181325
93Papillary thyroid carcinoma (HP:0002895)1.52867088
94Aplasia/Hypoplasia of the hallux (HP:0008362)1.52772419
95Fused cervical vertebrae (HP:0002949)1.50412089
96Progressive visual loss (HP:0000529)1.49075490
97Coarse hair (HP:0002208)1.46523235
98Abnormality of the vitamin B12 metabolism (HP:0004341)1.45858573
99Stenosis of the external auditory canal (HP:0000402)1.44448569
100Abnormality of the prostate (HP:0008775)1.43589708

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK25.04085142
2BCKDK2.79011913
3MUSK11.2149940
4PIK3CG10.5157126
5ACVR1B1.99000853
6TNIK1.89551283
7FGFR21.87958976
8WNK31.71852062
9MAP3K121.24321462
10LMTK21.09933879
11NLK0.78580921
12FGFR40.72518866
13IRAK20.66487729
14MARK30.66443838
15TAF10.61956015
16PRKCG0.61835540
17MYLK0.60537728
18NEK90.58222587
19EPHA40.55209547
20CDK190.51768319
21GRK10.51749593
22NUAK10.49146471
23NEK10.48953103
24MAPK110.48403153
25EPHB10.44719485
26PBK0.44177914
27PDK20.40051860
28PRKACB0.39738531
29NTRK30.39126642
30CSNK1G20.36499250
31GRK60.36420362
32STK240.35781142
33GRK50.35695199
34NME10.35415478
35PRKCE0.35203606
36FGFR10.34922902
37FRK0.33808614
38BRD40.32820793
39LRRK20.32486047
40EPHA30.30343312
41TYK20.30317526
42ABL20.29438518
43ADRBK20.28627414
44TXK0.28333185
45JAK10.27106951
46PASK0.26768923
47NEK60.26559086
48PTK2B0.26296653
49PIM20.26064829
50OBSCN0.25466763
51MAP3K90.24255907
52MAP2K60.23090366
53MAP3K20.22189007
54MET0.20739139
55RIPK10.20405714
56MKNK20.19489596
57AKT20.19359839
58ERBB40.19230641
59PRKCZ0.18603668
60ITK0.18466847
61PDPK10.18393593
62PDK10.17622969
63PTK20.15848589
64PRKG20.15761794
65IRAK40.15482407
66KDR0.15336208
67PRKAA20.14402512
68CSNK1D0.13455810
69ARAF0.13369656
70PRKACG0.13126792
71PAK30.13067311
72FGFR30.11415064
73GSK3A0.11360440
74RIPK40.11047891
75CSF1R0.10747616
76IRAK10.10547696
77PAK40.09280839
78INSRR0.09032697
79ERN10.08879690
80MTOR0.08067868
81FER0.07497583
82CSNK2A20.06920521
83CDK11A0.06035958
84NTRK10.05860277
85MATK0.04320145
86PRKCB0.04252137
87PRKCA0.03922773
88PRKCI0.03903455
89INSR0.03899451
90PDGFRB0.03722407
91CSNK2A10.03652981
92PDGFRA0.03615596
93CDK150.03252219
94ROCK10.03110627
95PRKACA0.03070054
96EPHA20.03033622
97CSK0.02813974
98SGK2230.02677082
99SGK4940.02677082
100IGF1R0.02346258

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin digestion and absorption_Homo sapiens_hsa049778.03994689
2Galactose metabolism_Homo sapiens_hsa000524.90404132
3Fat digestion and absorption_Homo sapiens_hsa049754.22724055
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.21264715
5Mineral absorption_Homo sapiens_hsa049784.18813620
6Linoleic acid metabolism_Homo sapiens_hsa005913.12258076
7Carbohydrate digestion and absorption_Homo sapiens_hsa049732.71504003
8Complement and coagulation cascades_Homo sapiens_hsa046102.41382255
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.29687644
10PPAR signaling pathway_Homo sapiens_hsa033202.20756972
11Ether lipid metabolism_Homo sapiens_hsa005652.13962438
12Glycerophospholipid metabolism_Homo sapiens_hsa005641.91758745
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.89583163
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.79139831
15Sphingolipid metabolism_Homo sapiens_hsa006001.78817644
16Selenocompound metabolism_Homo sapiens_hsa004501.73972558
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.63182938
18Chemical carcinogenesis_Homo sapiens_hsa052041.59277749
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.53574463
20Pentose phosphate pathway_Homo sapiens_hsa000301.36595134
21Arachidonic acid metabolism_Homo sapiens_hsa005901.34291945
22Bile secretion_Homo sapiens_hsa049761.30874061
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.30125516
24Tryptophan metabolism_Homo sapiens_hsa003801.22121367
25Fructose and mannose metabolism_Homo sapiens_hsa000511.19000325
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18407206
27Glycerolipid metabolism_Homo sapiens_hsa005611.14587717
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.10866048
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07069534
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06888234
31Fatty acid elongation_Homo sapiens_hsa000621.03454100
32Arginine and proline metabolism_Homo sapiens_hsa003301.02131224
33Other glycan degradation_Homo sapiens_hsa005110.93701954
34Glutathione metabolism_Homo sapiens_hsa004800.90275902
35Fatty acid degradation_Homo sapiens_hsa000710.86615405
36Inositol phosphate metabolism_Homo sapiens_hsa005620.85804929
37ABC transporters_Homo sapiens_hsa020100.83122539
38Primary bile acid biosynthesis_Homo sapiens_hsa001200.79313758
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79014461
40Retinol metabolism_Homo sapiens_hsa008300.72297547
41Nicotine addiction_Homo sapiens_hsa050330.69111617
42Steroid hormone biosynthesis_Homo sapiens_hsa001400.68402295
43African trypanosomiasis_Homo sapiens_hsa051430.67019158
44Carbon metabolism_Homo sapiens_hsa012000.65507852
45Salivary secretion_Homo sapiens_hsa049700.62095416
46Starch and sucrose metabolism_Homo sapiens_hsa005000.61771097
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57028750
48Protein digestion and absorption_Homo sapiens_hsa049740.54311814
49One carbon pool by folate_Homo sapiens_hsa006700.52430233
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51362256
51Metabolic pathways_Homo sapiens_hsa011000.50644475
52Staphylococcus aureus infection_Homo sapiens_hsa051500.48273817
53Propanoate metabolism_Homo sapiens_hsa006400.46000615
54Arginine biosynthesis_Homo sapiens_hsa002200.44552141
55Butanoate metabolism_Homo sapiens_hsa006500.40890074
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.40143443
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40014440
58N-Glycan biosynthesis_Homo sapiens_hsa005100.39516939
59Nitrogen metabolism_Homo sapiens_hsa009100.35762748
60Tyrosine metabolism_Homo sapiens_hsa003500.35269667
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33049251
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31717900
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31712844
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31009602
65Thyroid hormone synthesis_Homo sapiens_hsa049180.30523216
66Ovarian steroidogenesis_Homo sapiens_hsa049130.29805100
67Type II diabetes mellitus_Homo sapiens_hsa049300.28684612
68Renin-angiotensin system_Homo sapiens_hsa046140.27854550
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27464857
70Histidine metabolism_Homo sapiens_hsa003400.26937344
71Phototransduction_Homo sapiens_hsa047440.26922577
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.26777863
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26303223
74Fatty acid metabolism_Homo sapiens_hsa012120.26204025
75Peroxisome_Homo sapiens_hsa041460.22705246
76Hedgehog signaling pathway_Homo sapiens_hsa043400.21534562
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.17937806
78Purine metabolism_Homo sapiens_hsa002300.17934966
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.17886799
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17752775
81Lysosome_Homo sapiens_hsa041420.16098216
82Caffeine metabolism_Homo sapiens_hsa002320.15064645
83Morphine addiction_Homo sapiens_hsa050320.12662921
84Dorso-ventral axis formation_Homo sapiens_hsa043200.11050309
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.10927689
86Circadian rhythm_Homo sapiens_hsa047100.09476684
87ECM-receptor interaction_Homo sapiens_hsa045120.07692906
88beta-Alanine metabolism_Homo sapiens_hsa004100.07304421
89Biosynthesis of amino acids_Homo sapiens_hsa012300.07009635
90Glucagon signaling pathway_Homo sapiens_hsa049220.06602530
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.06602348
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.06349584
93Phenylalanine metabolism_Homo sapiens_hsa003600.06081292
94Hippo signaling pathway_Homo sapiens_hsa043900.05678882
95Pancreatic secretion_Homo sapiens_hsa049720.02915514
96Tight junction_Homo sapiens_hsa045300.02316300
97Cocaine addiction_Homo sapiens_hsa050300.02135585
98Pyruvate metabolism_Homo sapiens_hsa006200.01839633
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.01153394
100Folate biosynthesis_Homo sapiens_hsa00790-0.0139292

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