GNPTG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the gamma sunbunit of the N-acetylglucosamine-1-phosphotransferase complex. This hexameric complex, composed of alpha, beta and gamma subunits, catalyzes the first step in synthesis of a mannose 6-phosphate lysosomal recognition marker. This enzyme complex is necessary for targeting of lysosomal hydrolases to the lysosome. Mutations in the gene encoding the gamma subunit have been associated with mucolipidosis IIIC, also known as mucolipidosis III gamma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)4.55301932
2Golgi transport vesicle coating (GO:0048200)4.55301932
3regulation of synaptic vesicle exocytosis (GO:2000300)4.04517950
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.04225048
5regulation of short-term neuronal synaptic plasticity (GO:0048172)3.94334502
6protein maturation by protein folding (GO:0022417)3.92027599
7neuronal action potential propagation (GO:0019227)3.72918905
8regulation of synaptic vesicle transport (GO:1902803)3.70388528
9signal peptide processing (GO:0006465)3.68529933
10synaptic vesicle exocytosis (GO:0016079)3.65902036
11presynaptic membrane assembly (GO:0097105)3.65056168
12presynaptic membrane organization (GO:0097090)3.51763120
13detection of calcium ion (GO:0005513)3.48724005
14peptide hormone processing (GO:0016486)3.47469977
15negative regulation of interleukin-12 production (GO:0032695)3.42279744
16postsynaptic membrane organization (GO:0001941)3.37316414
17synaptic vesicle maturation (GO:0016188)3.36137878
18endocrine pancreas development (GO:0031018)3.34438263
19neuron cell-cell adhesion (GO:0007158)3.28892494
20regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.27490749
21maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.16675333
22glutamate secretion (GO:0014047)3.09430420
23insulin secretion (GO:0030073)3.09014497
24amino sugar catabolic process (GO:0046348)3.08753743
25positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.04814197
26locomotory exploration behavior (GO:0035641)3.03951031
27neuromuscular process controlling posture (GO:0050884)3.02602840
28positive regulation of synaptic transmission, GABAergic (GO:0032230)3.00410103
29protein retention in ER lumen (GO:0006621)2.99786329
30neurotransmitter secretion (GO:0007269)2.98809666
31magnesium ion transport (GO:0015693)2.96319207
32virion attachment to host cell (GO:0019062)2.96274423
33adhesion of symbiont to host cell (GO:0044650)2.96274423
34positive regulation of insulin secretion (GO:0032024)2.91178441
35neurotransmitter-gated ion channel clustering (GO:0072578)2.90161505
36negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.89759486
37negative regulation of cell killing (GO:0031342)2.89759486
38negative regulation of nitric oxide biosynthetic process (GO:0045019)2.88511511
39negative regulation of mast cell activation (GO:0033004)2.87832895
40negative regulation of catecholamine secretion (GO:0033604)2.87648371
41synaptic transmission, glutamatergic (GO:0035249)2.86910575
42retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.86211920
43regulation of vesicle fusion (GO:0031338)2.85657533
44hydrogen peroxide biosynthetic process (GO:0050665)2.84927975
45macrophage activation involved in immune response (GO:0002281)2.84599229
46regulation of insulin secretion (GO:0050796)2.84057697
47regulation of type B pancreatic cell apoptotic process (GO:2000674)2.83747789
48glandular epithelial cell differentiation (GO:0002067)2.83686541
49cerebellar Purkinje cell layer development (GO:0021680)2.80347999
50regulation of neuronal synaptic plasticity (GO:0048168)2.79195070
51regulation of mononuclear cell migration (GO:0071675)2.79140386
52ER overload response (GO:0006983)2.79130061
53neutrophil activation involved in immune response (GO:0002283)2.79038406
54positive regulation of membrane potential (GO:0045838)2.78657196
55regulation of autophagic vacuole assembly (GO:2000785)2.76534757
56response to peptidoglycan (GO:0032494)2.76006764
57regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.73734006
58response to pheromone (GO:0019236)2.73237659
59regulation of beta-amyloid formation (GO:1902003)2.72871621
60positive regulation of exocytosis (GO:0045921)2.72522524
61long-term synaptic potentiation (GO:0060291)2.72401395
62regulation of glucocorticoid secretion (GO:2000849)2.72212428
63cellular potassium ion homeostasis (GO:0030007)2.71097492
64positive regulation of amino acid transport (GO:0051957)2.69796325
65microglial cell activation (GO:0001774)2.68805368
66regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.68579818
67ionotropic glutamate receptor signaling pathway (GO:0035235)2.68020266
68neuron-neuron synaptic transmission (GO:0007270)2.67720420
69regulation of calcium ion-dependent exocytosis (GO:0017158)2.66992129
70energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.65919631
71ATP hydrolysis coupled proton transport (GO:0015991)2.65919631
72positive regulation of heat generation (GO:0031652)2.65605410
73negative regulation of norepinephrine secretion (GO:0010700)2.65037937
74synaptic vesicle docking involved in exocytosis (GO:0016081)2.64905654
75response to dietary excess (GO:0002021)2.64878340
76axon ensheathment in central nervous system (GO:0032291)2.64747622
77central nervous system myelination (GO:0022010)2.64747622
78positive regulation of antigen processing and presentation (GO:0002579)2.64110136
79transferrin transport (GO:0033572)2.63116696
80reactive oxygen species biosynthetic process (GO:1903409)2.63062330
81protein localization to synapse (GO:0035418)2.62358908
82lytic vacuole organization (GO:0080171)2.62097085
83lysosome organization (GO:0007040)2.62097085
84regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.61996817
85ceramide catabolic process (GO:0046514)2.61978252
86regulation of dopamine metabolic process (GO:0042053)2.61737375
87regulation of catecholamine metabolic process (GO:0042069)2.61737375
88regulation of peptide hormone secretion (GO:0090276)2.61669636
89regulation of mast cell degranulation (GO:0043304)2.61574960
90regulation of amyloid precursor protein catabolic process (GO:1902991)2.61408021
91regulation of peptide secretion (GO:0002791)2.59749769
92neurotransmitter transport (GO:0006836)2.58907296
93immunoglobulin mediated immune response (GO:0016064)2.58432394
94regulation of glutamate receptor signaling pathway (GO:1900449)2.57839125
95cellular response to glucagon stimulus (GO:0071377)2.57534750
96adhesion of symbiont to host (GO:0044406)2.56305694
97positive regulation of mast cell activation involved in immune response (GO:0033008)2.54817188
98positive regulation of mast cell degranulation (GO:0043306)2.54817188
99regulation of neurotransmitter secretion (GO:0046928)2.54178394
100N-acetylneuraminate metabolic process (GO:0006054)2.54019915
101long-term memory (GO:0007616)2.53491014
102glycosphingolipid catabolic process (GO:0046479)2.50871998
103chemosensory behavior (GO:0007635)2.50525126
104intraciliary transport (GO:0042073)2.48929198
105regulation of antigen processing and presentation (GO:0002577)2.48805853
106regulation of mast cell activation (GO:0033003)2.48443572
107regulation of norepinephrine secretion (GO:0014061)2.48108481
108negative regulation of neurotransmitter transport (GO:0051589)2.48081950
109glutamate receptor signaling pathway (GO:0007215)2.47207620
110ferric iron transport (GO:0015682)2.47007002
111trivalent inorganic cation transport (GO:0072512)2.47007002
112T-helper 1 type immune response (GO:0042088)2.46559852
113positive regulation of mast cell activation (GO:0033005)2.45777818
114regulation of exocytosis (GO:0017157)2.45635070
115transmission of nerve impulse (GO:0019226)2.45484479
116startle response (GO:0001964)2.45272502
117establishment of synaptic vesicle localization (GO:0097480)2.45134528
118synaptic vesicle transport (GO:0048489)2.45134528
119positive regulation of cholesterol efflux (GO:0010875)2.45115492
120positive regulation of peptide secretion (GO:0002793)2.45085497
121negative regulation of neurotransmitter secretion (GO:0046929)2.44228540
122membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.44059223
123positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.43721402
124positive regulation of peptide hormone secretion (GO:0090277)2.43162089
125positive regulation of gamma-delta T cell activation (GO:0046645)2.43135972
126response to redox state (GO:0051775)2.43004706
127regulation of cholesterol storage (GO:0010885)2.42527412
128positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.42026083
129synaptic vesicle endocytosis (GO:0048488)2.41667479
130female mating behavior (GO:0060180)2.41646391
131positive regulation of chemokine biosynthetic process (GO:0045080)2.40746829
132regulation of long-term neuronal synaptic plasticity (GO:0048169)2.40550872
133regulation of oxidative phosphorylation (GO:0002082)2.40413232
134regulation of heat generation (GO:0031650)2.40175555
135regulation of chemokine biosynthetic process (GO:0045073)2.40008549
136phagosome maturation (GO:0090382)2.39968846
137phosphatidylglycerol biosynthetic process (GO:0006655)2.39894208
138mannosylation (GO:0097502)2.39721401
139regulation of mast cell activation involved in immune response (GO:0033006)2.38803609
140vocalization behavior (GO:0071625)2.38723538
141negative regulation of tumor necrosis factor production (GO:0032720)2.38371393
142positive regulation of prostaglandin secretion (GO:0032308)2.38086091
143dopamine biosynthetic process (GO:0042416)2.38047411
144negative regulation of cytokine production involved in immune response (GO:0002719)2.37956091
145macrophage activation (GO:0042116)2.35148846
146regulation of fever generation (GO:0031620)2.34636579
147oligosaccharide catabolic process (GO:0009313)2.32482253
148negative regulation of leukocyte chemotaxis (GO:0002689)2.32408856
149NIK/NF-kappaB signaling (GO:0038061)2.32386292
150myeloid cell activation involved in immune response (GO:0002275)2.31938534
151negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.30664702
152autophagic vacuole fusion (GO:0000046)2.28150318
153negative regulation of interleukin-1 beta production (GO:0032691)2.27935591
154mature B cell differentiation involved in immune response (GO:0002313)2.27301180
155indole-containing compound catabolic process (GO:0042436)2.27110129
156indolalkylamine catabolic process (GO:0046218)2.27110129
157tryptophan catabolic process (GO:0006569)2.27110129
158glycolipid catabolic process (GO:0019377)2.26753347
159interferon-gamma-mediated signaling pathway (GO:0060333)2.26420645
160positive regulation of fatty acid transport (GO:2000193)2.26257014
161regulation of T cell mediated cytotoxicity (GO:0001914)2.25359788
162granulocyte activation (GO:0036230)2.24794303
163positive regulation of sterol transport (GO:0032373)2.24503398
164positive regulation of cholesterol transport (GO:0032376)2.24503398
165response to protozoan (GO:0001562)2.22034393
166negative regulation of innate immune response (GO:0045824)2.21806050
167lipopolysaccharide-mediated signaling pathway (GO:0031663)2.21729365
168positive regulation of calcium-mediated signaling (GO:0050850)2.21562332
169negative regulation of interleukin-1 production (GO:0032692)2.21066754
170antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.19918492
171defense response to protozoan (GO:0042832)2.19723891
172lymphocyte chemotaxis (GO:0048247)2.18566780
173antigen processing and presentation of endogenous antigen (GO:0019883)2.17156444
174cellular response to thyroid hormone stimulus (GO:0097067)2.16774565
175regulation of myeloid leukocyte mediated immunity (GO:0002886)2.15892936
176regulation of leukocyte degranulation (GO:0043300)2.15199737
177positive regulation of monocyte chemotaxis (GO:0090026)2.15106799
178antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.14905243
179macrophage chemotaxis (GO:0048246)2.13349280
180monocyte chemotaxis (GO:0002548)2.12957354
181positive regulation by symbiont of host defense response (GO:0052509)2.12397957
182modulation by symbiont of host defense response (GO:0052031)2.12397957
183modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.12397957
184modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.12397957
185positive regulation by organism of defense response of other organism involved in symbiotic interact2.12397957
186modulation by symbiont of host immune response (GO:0052553)2.12397957
187response to pH (GO:0009268)2.10894702
188regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.10685404
189regulation of macrophage chemotaxis (GO:0010758)2.09782605
190positive regulation of icosanoid secretion (GO:0032305)2.08392675
191regulation of vitamin D biosynthetic process (GO:0060556)2.07703044
192positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.07301150
193superoxide anion generation (GO:0042554)2.06076845
194positive regulation of T cell mediated cytotoxicity (GO:0001916)2.05944555
195fat-soluble vitamin biosynthetic process (GO:0042362)2.05286709
196negative regulation of interleukin-6 production (GO:0032715)2.04022038
197sphingolipid catabolic process (GO:0030149)2.03621180

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.01608851
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.26781825
3GBX2_23144817_ChIP-Seq_PC3_Human3.20608972
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.00394035
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.89053195
6REST_21632747_ChIP-Seq_MESCs_Mouse2.69845710
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.65064640
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.59959514
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.38914273
10SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36076900
11* REST_18959480_ChIP-ChIP_MESCs_Mouse2.34174130
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.22077134
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.20192697
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.17775440
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.16795301
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.15173767
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13949203
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.13480888
19LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.13020741
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.07049498
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.03662748
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.03425153
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.01128764
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.99457015
25IRF8_27001747_Chip-Seq_BMDM_Mouse1.98930955
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97380927
27LXR_22292898_ChIP-Seq_THP-1_Human1.95531854
28RARB_27405468_Chip-Seq_BRAIN_Mouse1.90668565
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.89985987
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.86672502
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.85086178
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.83638869
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.83638869
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.83272481
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79804950
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.75214711
37STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.75071945
38* BCL6_27268052_Chip-Seq_Bcells_Human1.74769374
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.73953612
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73933012
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.72446767
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69993436
43DROSHA_22980978_ChIP-Seq_HELA_Human1.67648812
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65569034
45VDR_21846776_ChIP-Seq_THP-1_Human1.65450326
46GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.63018452
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62173549
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.61357196
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53817829
50* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.51580163
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51500458
52* BCOR_27268052_Chip-Seq_Bcells_Human1.50575175
53TAF15_26573619_Chip-Seq_HEK293_Human1.49330002
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48939492
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.48678269
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.48210681
57DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.45798672
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44647343
59VDR_24763502_ChIP-Seq_THP-1_Human1.43659770
60NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.42508721
61MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.41635282
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.41445307
63CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.40845390
64SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40258956
65* P68_20966046_ChIP-Seq_HELA_Human1.38963739
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38873490
67ZNF274_21170338_ChIP-Seq_K562_Hela1.38078039
68IGF1R_20145208_ChIP-Seq_DFB_Human1.37415670
69VDR_22108803_ChIP-Seq_LS180_Human1.36708786
70* ELF1_20517297_ChIP-Seq_JURKAT_Human1.36011174
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33216994
72CTCF_20526341_ChIP-Seq_ESCs_Human1.32386597
73SPI1_23127762_ChIP-Seq_K562_Human1.31961009
74SA1_27219007_Chip-Seq_Bcells_Human1.31945874
75STAT1_20625510_ChIP-Seq_HELA_Human1.31047212
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30888245
77RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29498619
78SMAD4_21799915_ChIP-Seq_A2780_Human1.26764447
79VDR_24787735_ChIP-Seq_THP-1_Human1.26364145
80PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.25698248
81P300_19829295_ChIP-Seq_ESCs_Human1.25588616
82POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25371448
83* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.23582487
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23407420
85SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22942886
86ESR2_21235772_ChIP-Seq_MCF-7_Human1.22612136
87SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19630326
88EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.18745873
89IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17796123
90NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16585941
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16548164
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15533387
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.15303743
94RUNX_20019798_ChIP-Seq_JUKART_Human1.14975943
95E2F1_20622854_ChIP-Seq_HELA_Human1.14961861
96* SA1_27219007_Chip-Seq_ERYTHROID_Human1.12799639
97ERG_21242973_ChIP-ChIP_JURKAT_Human1.12645601
98OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.12300799
99SCL_19346495_ChIP-Seq_HPC-7_Human1.12300658
100PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12139431
101GATA1_19941827_ChIP-Seq_MEL_Mouse1.11637171
102CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11208760
103PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10890108
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10620933
105STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10560119
106RAD21_21589869_ChIP-Seq_MESCs_Mouse1.09308907
107CTCF_26484167_Chip-Seq_Bcells_Mouse1.08771855
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08370668
109TAF2_19829295_ChIP-Seq_ESCs_Human1.06768943
110PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06713321
111* SMC4_20622854_ChIP-Seq_HELA_Human1.06054684
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05950789
113* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05636723
114RXR_22158963_ChIP-Seq_LIVER_Mouse1.05462351
115* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04904676
116TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04234811
117RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03001763
118AR_25329375_ChIP-Seq_VCAP_Human1.01925267
119REST_19997604_ChIP-ChIP_NEURONS_Mouse1.01224016
120SMC3_22415368_ChIP-Seq_MEFs_Mouse1.01102749
121DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00933728
122SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00831402
123STAT3_23295773_ChIP-Seq_U87_Human1.00572491
124TET1_21451524_ChIP-Seq_MESCs_Mouse1.00399391
125HTT_18923047_ChIP-ChIP_STHdh_Human0.99866318
126CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99751598
127Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99563130
128* P300_27268052_Chip-Seq_Bcells_Human0.99106684
129CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98868342
130SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98863375
131OCT4_19829295_ChIP-Seq_ESCs_Human0.97774014
132PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97319004
133CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96328781
134P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.96250790
135RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96071825
136* PHF8_20622854_ChIP-Seq_HELA_Human0.95727285
137BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95031941
138ERA_21632823_ChIP-Seq_H3396_Human0.94793360
139CBX2_27304074_Chip-Seq_ESCs_Mouse0.93266597
140RUNX1_22412390_ChIP-Seq_EML_Mouse0.93075822
141NANOG_18555785_Chip-Seq_ESCs_Mouse0.91893315
142CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91836981
143AR_21572438_ChIP-Seq_LNCaP_Human0.91754178
144FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.91579790
145PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91066190
146YY1_22570637_ChIP-Seq_MALME-3M_Human0.90363881
147FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90092161
148RUNX2_22187159_ChIP-Seq_PCA_Human0.89390355
149TP63_22573176_ChIP-Seq_HFKS_Human0.88971045
150RNF2_27304074_Chip-Seq_NSC_Mouse0.88939809
151SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88692036
152MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87290335
153SOX2_21211035_ChIP-Seq_LN229_Gbm0.86293571
154ETV2_25802403_ChIP-Seq_MESCs_Mouse0.85094045
155BCAT_22108803_ChIP-Seq_LS180_Human0.84182796
156P53_22127205_ChIP-Seq_FIBROBLAST_Human0.83313161
157TP53_22573176_ChIP-Seq_HFKS_Human0.83204939
158NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83047388
159TAL1_26923725_Chip-Seq_HPCs_Mouse0.82062041
160SMAD3_21741376_ChIP-Seq_EPCs_Human0.80777983
161SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79472007
162SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78667409
163TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.78459259
164AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78432599
165TCF4_23295773_ChIP-Seq_U87_Human0.78336928
166P53_22387025_ChIP-Seq_ESCs_Mouse0.78006190
167NANOG_19829295_ChIP-Seq_ESCs_Human0.77976975
168SOX2_19829295_ChIP-Seq_ESCs_Human0.77976975
169TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.77966939
170VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.77936198
171SMAD3_21741376_ChIP-Seq_ESCs_Human0.77866412
172EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.76986244
173RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.76759640
174CTCF_27219007_Chip-Seq_Bcells_Human0.76543635
175SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.76429483
176STAT3_18555785_Chip-Seq_ESCs_Mouse0.75541819
177SOX2_18555785_Chip-Seq_ESCs_Mouse0.75351152
178AR_19668381_ChIP-Seq_PC3_Human0.74830092

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation3.26352371
2MP0004859_abnormal_synaptic_plasticity3.18327680
3MP0009840_abnormal_foam_cell3.15336954
4MP0003880_abnormal_central_pattern3.14048207
5MP0006082_CNS_inflammation3.00563718
6MP0010386_abnormal_urinary_bladder2.93464717
7MP0003303_peritoneal_inflammation2.85553679
8MP0003724_increased_susceptibility_to2.79356147
9MP0005646_abnormal_pituitary_gland2.76135998
10MP0002148_abnormal_hypersensitivity_rea2.72448865
11MP0002909_abnormal_adrenal_gland2.70523856
12MP0003436_decreased_susceptibility_to2.70350639
13MP0004270_analgesia2.66147783
14MP0005645_abnormal_hypothalamus_physiol2.64526839
15MP0003635_abnormal_synaptic_transmissio2.61248629
16MP0000013_abnormal_adipose_tissue2.57069709
17MP0009780_abnormal_chondrocyte_physiolo2.45527829
18MP0005671_abnormal_response_to2.36577853
19MP0009785_altered_susceptibility_to2.28845802
20MP0002064_seizures2.27391230
21MP0002272_abnormal_nervous_system2.23686893
22MP0000604_amyloidosis2.20485674
23MP0002638_abnormal_pupillary_reflex2.17479978
24MP0009745_abnormal_behavioral_response2.16308277
25MP0002419_abnormal_innate_immunity2.12091554
26MP0002734_abnormal_mechanical_nocicepti2.07046300
27MP0009046_muscle_twitch2.05464571
28MP0005423_abnormal_somatic_nervous2.03905659
29MP0001984_abnormal_olfaction2.03101451
30MP0001986_abnormal_taste_sensitivity2.02560829
31MP0002063_abnormal_learning/memory/cond2.02308590
32MP0003195_calcinosis2.01964658
33MP0002572_abnormal_emotion/affect_behav2.01618885
34MP0005379_endocrine/exocrine_gland_phen2.01299872
35MP0000685_abnormal_immune_system2.00263453
36MP0002139_abnormal_hepatobiliary_system1.99643343
37MP0003075_altered_response_to1.98900334
38MP0006072_abnormal_retinal_apoptosis1.97931468
39MP0001835_abnormal_antigen_presentation1.97253324
40MP0005000_abnormal_immune_tolerance1.96684555
41MP0002693_abnormal_pancreas_physiology1.95994787
42MP0005025_abnormal_response_to1.94824938
43MP0009764_decreased_sensitivity_to1.90338488
44MP0005167_abnormal_blood-brain_barrier1.89848119
45MP0001968_abnormal_touch/_nociception1.89585247
46MP0002822_catalepsy1.88469250
47MP0001790_abnormal_immune_system1.87642215
48MP0005387_immune_system_phenotype1.87642215
49MP0001944_abnormal_pancreas_morphology1.87147306
50MP0001502_abnormal_circadian_rhythm1.83495279
51MP0001533_abnormal_skeleton_physiology1.80215423
52MP0000343_altered_response_to1.78116388
53MP0004885_abnormal_endolymph1.76709321
54MP0001501_abnormal_sleep_pattern1.76612907
55MP0003122_maternal_imprinting1.70989987
56MP0006276_abnormal_autonomic_nervous1.65200725
57MP0001970_abnormal_pain_threshold1.64007716
58MP0002723_abnormal_immune_serum1.61449480
59MP0009278_abnormal_bone_marrow1.60373497
60MP0005551_abnormal_eye_electrophysiolog1.59489843
61MP0002736_abnormal_nociception_after1.58880655
62MP0002452_abnormal_antigen_presenting1.57225045
63MP0002876_abnormal_thyroid_physiology1.56804221
64MP0001529_abnormal_vocalization1.55349858
65MP0003329_amyloid_beta_deposits1.54247997
66MP0003806_abnormal_nucleotide_metabolis1.53985996
67MP0003136_yellow_coat_color1.53981856
68MP0002733_abnormal_thermal_nociception1.53573761
69MP0002877_abnormal_melanocyte_morpholog1.53170794
70MP0001486_abnormal_startle_reflex1.52454873
71MP0002067_abnormal_sensory_capabilities1.51221846
72MP0003879_abnormal_hair_cell1.50540629
73MP0004510_myositis1.50519280
74MP0001800_abnormal_humoral_immune1.50033144
75MP0003283_abnormal_digestive_organ1.47394667
76MP0002557_abnormal_social/conspecific_i1.45193641
77MP0002735_abnormal_chemical_nociception1.44332931
78* MP0003183_abnormal_peptide_metabolism1.43734145
79MP0001440_abnormal_grooming_behavior1.43580911
80MP0001905_abnormal_dopamine_level1.39332406
81MP0001765_abnormal_ion_homeostasis1.37835055
82MP0002653_abnormal_ependyma_morphology1.37663572
83MP0000631_abnormal_neuroendocrine_gland1.37629933
84MP0008569_lethality_at_weaning1.36758779
85MP0004142_abnormal_muscle_tone1.35911738
86MP0002420_abnormal_adaptive_immunity1.34181900
87MP0008469_abnormal_protein_level1.33885627
88MP0001819_abnormal_immune_cell1.33772263
89MP0003191_abnormal_cellular_cholesterol1.31860494
90MP0000678_abnormal_parathyroid_gland1.31411135
91MP0002998_abnormal_bone_remodeling1.31276447
92MP0005220_abnormal_exocrine_pancreas1.30898829
93MP0001845_abnormal_inflammatory_respons1.30442219
94MP0005365_abnormal_bile_salt1.30309415
95MP0002184_abnormal_innervation1.28456504
96MP0008875_abnormal_xenobiotic_pharmacok1.26843323
97MP0002229_neurodegeneration1.26663073
98MP0002837_dystrophic_cardiac_calcinosis1.26633790
99MP0002078_abnormal_glucose_homeostasis1.24509280
100MP0005084_abnormal_gallbladder_morpholo1.23288210
101MP0005058_abnormal_lysosome_morphology1.23072967
102MP0005253_abnormal_eye_physiology1.20769637
103MP0004924_abnormal_behavior1.17280994
104MP0005386_behavior/neurological_phenoty1.17280994
105MP0000955_abnormal_spinal_cord1.15326823
106MP0003172_abnormal_lysosome_physiology1.14847788
107MP0005166_decreased_susceptibility_to1.14838300
108MP0006292_abnormal_olfactory_placode1.13473457
109MP0001188_hyperpigmentation1.12759775
110MP0003633_abnormal_nervous_system1.12460040
111MP0002405_respiratory_system_inflammati1.11609601
112MP0000003_abnormal_adipose_tissue1.11573015
113MP0002138_abnormal_hepatobiliary_system1.10421409
114MP0002254_reproductive_system_inflammat1.10213879
115MP0002882_abnormal_neuron_morphology1.10130756
116MP0003011_delayed_dark_adaptation1.09408145
117MP0001664_abnormal_digestion1.07066616
118MP0002066_abnormal_motor_capabilities/c1.06951437
119MP0003634_abnormal_glial_cell1.06483448
120MP0005535_abnormal_body_temperature1.05605931
121MP0003953_abnormal_hormone_level1.03969051
122MP0002933_joint_inflammation1.03289970
123MP0005595_abnormal_vascular_smooth1.03235589
124MP0000920_abnormal_myelination1.02454269
125MP0001663_abnormal_digestive_system1.01633949
126MP0002069_abnormal_eating/drinking_beha1.00018134
127MP0000778_abnormal_nervous_system0.99741978
128MP0005464_abnormal_platelet_physiology0.99712825
129MP0010155_abnormal_intestine_physiology0.99381836
130MP0005636_abnormal_mineral_homeostasis0.97575065
131MP0004811_abnormal_neuron_physiology0.95998141
132MP0005310_abnormal_salivary_gland0.93904897
133MP0004019_abnormal_vitamin_homeostasis0.93885903
134MP0005397_hematopoietic_system_phenotyp0.93670780
135MP0001545_abnormal_hematopoietic_system0.93670780
136MP0001485_abnormal_pinna_reflex0.93144238
137MP0005390_skeleton_phenotype0.92895779
138MP0004858_abnormal_nervous_system0.92871207
139MP0001542_abnormal_bone_strength0.91618468
140MP0001756_abnormal_urination0.90589243
141MP0002090_abnormal_vision0.90417411
142MP0004947_skin_inflammation0.88150933
143MP0009333_abnormal_splenocyte_physiolog0.87673515
144MP0004742_abnormal_vestibular_system0.87265670
145MP0003690_abnormal_glial_cell0.84856441
146MP0001963_abnormal_hearing_physiology0.84764533
147MP0005394_taste/olfaction_phenotype0.84702035
148MP0005499_abnormal_olfactory_system0.84702035
149MP0003868_abnormal_feces_composition0.83370774
150MP0005360_urolithiasis0.81295754
151MP0003631_nervous_system_phenotype0.80971917
152MP0000716_abnormal_immune_system0.80510452
153MP0003300_gastrointestinal_ulcer0.80157373
154MP0003279_aneurysm0.77239662
155MP0010329_abnormal_lipoprotein_level0.76613255
156MP0000681_abnormal_thyroid_gland0.76370174
157MP0001764_abnormal_homeostasis0.75916039
158MP0001873_stomach_inflammation0.75294059
159MP0005174_abnormal_tail_pigmentation0.75133411
160MP0008874_decreased_physiological_sensi0.75002670
161MP0005171_absent_coat_pigmentation0.74419917
162MP0003959_abnormal_lean_body0.74358815
163MP0000230_abnormal_systemic_arterial0.72503755
164MP0004145_abnormal_muscle_electrophysio0.72228620
165MP0001853_heart_inflammation0.71461138
166MP0009643_abnormal_urine_homeostasis0.71070044

Predicted human phenotypes

RankGene SetZ-score
1* Abnormality of glycolipid metabolism (HP:0010969)6.02129458
2* Abnormality of liposaccharide metabolism (HP:0010968)6.02129458
3* Abnormality of glycosphingolipid metabolism (HP:0004343)6.02129458
4Increased cerebral lipofuscin (HP:0011813)5.14760958
5Increased neuronal autofluorescent lipopigment (HP:0002074)4.73699169
6Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.14214947
7Systemic lupus erythematosus (HP:0002725)4.12489413
8Focal motor seizures (HP:0011153)3.88747006
9Hypoglycemic seizures (HP:0002173)3.84914379
10Abnormality of macrophages (HP:0004311)3.69721934
11Decreased circulating renin level (HP:0003351)3.67906207
12Hyperinsulinemic hypoglycemia (HP:0000825)3.63631473
13Symptomatic seizures (HP:0011145)3.61854533
14Loss of speech (HP:0002371)3.53874892
15Mutism (HP:0002300)3.46190320
16Hyperactive renin-angiotensin system (HP:0000841)3.40488043
17Increased circulating renin level (HP:0000848)3.31019241
18Abnormality of calcium-phosphate metabolism (HP:0100530)3.18754506
19Myositis (HP:0100614)3.16234005
20Abnormality of renin-angiotensin system (HP:0000847)3.14414194
21Visual hallucinations (HP:0002367)3.09297355
22Hypothermia (HP:0002045)3.09254849
23Atonic seizures (HP:0010819)3.04831697
24Mesangial abnormality (HP:0001966)3.02560441
25Orchitis (HP:0100796)3.00052098
26Ketoacidosis (HP:0001993)2.96423181
27Stomatitis (HP:0010280)2.91749125
28Eczematoid dermatitis (HP:0000976)2.85112445
29Retrobulbar optic neuritis (HP:0100654)2.84618725
30Optic neuritis (HP:0100653)2.84618725
31Neuroendocrine neoplasm (HP:0100634)2.82623238
32Epileptic encephalopathy (HP:0200134)2.80940916
33Agitation (HP:0000713)2.79604740
34Mediastinal lymphadenopathy (HP:0100721)2.78447622
35Myokymia (HP:0002411)2.76095028
36Split foot (HP:0001839)2.75233642
37Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.74389403
38Pheochromocytoma (HP:0002666)2.74000067
39Hypokalemic alkalosis (HP:0001949)2.71222262
40Hyperaldosteronism (HP:0000859)2.68814717
41Axonal loss (HP:0003447)2.68624744
42Progressive neurologic deterioration (HP:0002344)2.68424233
43Recurrent abscess formation (HP:0002722)2.68412245
44Increased serum ferritin (HP:0003281)2.68236448
45Recurrent bacterial skin infections (HP:0005406)2.66663678
46Abnormality of aromatic amino acid family metabolism (HP:0004338)2.61315573
47Elevated erythrocyte sedimentation rate (HP:0003565)2.60686910
48* Dysostosis multiplex (HP:0000943)2.58731988
49Hypoglycemic coma (HP:0001325)2.56593524
50Autoimmune thrombocytopenia (HP:0001973)2.55798879
51Gout (HP:0001997)2.55459034
52Metabolic alkalosis (HP:0200114)2.54641327
53Supranuclear gaze palsy (HP:0000605)2.54443562
54Disinhibition (HP:0000734)2.54393552
55Focal seizures (HP:0007359)2.53872981
56Glomerulonephritis (HP:0000099)2.53062981
57Absence seizures (HP:0002121)2.52538399
58Epileptiform EEG discharges (HP:0011182)2.51739512
59EEG with generalized epileptiform discharges (HP:0011198)2.49520265
60Neurofibrillary tangles (HP:0002185)2.49368796
61Hypokalemia (HP:0002900)2.48935460
62Dialeptic seizures (HP:0011146)2.48884056
63Hypomagnesemia (HP:0002917)2.48063007
64Vacuolated lymphocytes (HP:0001922)2.47730373
65Anxiety (HP:0000739)2.47606054
66Medial flaring of the eyebrow (HP:0010747)2.45379902
67Recurrent gram-negative bacterial infections (HP:0005420)2.45307549
68Complement deficiency (HP:0004431)2.44800242
69Gait imbalance (HP:0002141)2.44791815
70Purpura (HP:0000979)2.44664018
71Nuclear cataract (HP:0100018)2.43513868
72Retinal dysplasia (HP:0007973)2.41669283
73Abnormality of magnesium homeostasis (HP:0004921)2.38601080
74Mucopolysacchariduria (HP:0008155)2.38223831
75Urinary glycosaminoglycan excretion (HP:0003541)2.38223831
76Nephrogenic diabetes insipidus (HP:0009806)2.37304383
77Pulmonary infiltrates (HP:0002113)2.36434112
78Amyloidosis (HP:0011034)2.35366109
79Congenital primary aphakia (HP:0007707)2.34708467
80Hypsarrhythmia (HP:0002521)2.32770685
81Large for gestational age (HP:0001520)2.30085070
82Late onset (HP:0003584)2.30024045
83Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.28505802
84Retinal atrophy (HP:0001105)2.28412831
85Polyphagia (HP:0002591)2.27986493
86Abnormality of polysaccharide metabolism (HP:0011012)2.27937898
87Abnormality of glycosaminoglycan metabolism (HP:0004371)2.27937898
88Abnormality of mucopolysaccharide metabolism (HP:0011020)2.27937898
89Prolonged neonatal jaundice (HP:0006579)2.27821558
90Abnormality of iron homeostasis (HP:0011031)2.27404142
91Generalized tonic-clonic seizures (HP:0002069)2.26352675
92Decreased electroretinogram (ERG) amplitude (HP:0000654)2.25055906
93Febrile seizures (HP:0002373)2.23759565
94Diplopia (HP:0000651)2.22967272
95Abnormality of binocular vision (HP:0011514)2.22967272
96Chronic bronchitis (HP:0004469)2.21212700
97Chronic obstructive pulmonary disease (HP:0006510)2.19589872
98Obstructive lung disease (HP:0006536)2.19589872
99Abnormal drinking behavior (HP:0030082)2.18744135
100Polydipsia (HP:0001959)2.18744135
101Abnormality of transition element cation homeostasis (HP:0011030)2.18497233
102Type II lissencephaly (HP:0007260)2.17395419
103Abnormal rod and cone electroretinograms (HP:0008323)2.15255552
104Global brain atrophy (HP:0002283)2.14472870
105Xanthomatosis (HP:0000991)2.11002260
106Megalencephaly (HP:0001355)2.10244442
107Dementia (HP:0000726)2.09905861
108Restlessness (HP:0000711)2.09765291
109Hyperventilation (HP:0002883)2.09746790
110Hyperglycemia (HP:0003074)2.08982867
111Cortical visual impairment (HP:0100704)2.07971652
112Abnormal eating behavior (HP:0100738)2.07074432
113Abolished electroretinogram (ERG) (HP:0000550)2.04888278
114Adrenal overactivity (HP:0002717)2.04597878
115Polyuria (HP:0000103)2.04138343
116Conjugated hyperbilirubinemia (HP:0002908)2.03709234
117Insulin-resistant diabetes mellitus (HP:0000831)2.03255560
118Cerebral inclusion bodies (HP:0100314)2.02990675
119Hematochezia (HP:0002573)2.02880567
120Hemoptysis (HP:0002105)2.01073958
121Depression (HP:0000716)1.99618985
122J-shaped sella turcica (HP:0002680)1.98396211
123Abnormality of endocrine pancreas physiology (HP:0012093)1.98211383
124Abnormality of the pancreatic islet cells (HP:0006476)1.98211383
125Pustule (HP:0200039)1.98021930
126Absent rod-and cone-mediated responses on ERG (HP:0007688)1.97710753
127Menstrual irregularities (HP:0000858)1.96706568
128Abnormal protein glycosylation (HP:0012346)1.95735798
129Abnormal glycosylation (HP:0012345)1.95735798
130Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95735798
131Abnormal protein N-linked glycosylation (HP:0012347)1.95735798
132Abnormality of potassium homeostasis (HP:0011042)1.95657674
133Alkalosis (HP:0001948)1.94128743
134Abnormal mitochondria in muscle tissue (HP:0008316)1.93942042
135Recurrent fungal infections (HP:0002841)1.93438580
136Acute necrotizing encephalopathy (HP:0006965)1.93240969
137Neuronal loss in central nervous system (HP:0002529)1.93238006
138Abnormality of chloride homeostasis (HP:0011422)1.92343210
139Hyperparathyroidism (HP:0000843)1.92007529
140Diminished motivation (HP:0000745)1.90155299
141Congenital stationary night blindness (HP:0007642)1.89051984
142Vaginal atresia (HP:0000148)1.88963285
143Abnormal urine output (HP:0012590)1.88591270
144Poor suck (HP:0002033)1.87802112
145Limb dystonia (HP:0002451)1.87307933
146Recurrent skin infections (HP:0001581)1.84473535
147Generalized aminoaciduria (HP:0002909)1.84200723
148Dysautonomia (HP:0002459)1.84105068
149Psychosis (HP:0000709)1.83167327
150Ankle clonus (HP:0011448)1.83152040
151Renal salt wasting (HP:0000127)1.82655544
152Pancreatic islet-cell hyperplasia (HP:0004510)1.82461637
153Genital tract atresia (HP:0001827)1.82430696
154Muscular hypotonia of the trunk (HP:0008936)1.82299928
155Petechiae (HP:0000967)1.82011355
156Abnormality of the fovea (HP:0000493)1.81063963
157Polyneuropathy (HP:0001271)1.77226088
158Abnormality of complement system (HP:0005339)1.77080964
159Cardiomegaly (HP:0001640)1.76902673
160Apathy (HP:0000741)1.75847722
161Abnormality of the vasculature of the conjunctiva (HP:0008054)1.74621362
162Abnormality of the periventricular white matter (HP:0002518)1.73513516
163Albinism (HP:0001022)1.71838511
164Bone cyst (HP:0012062)1.71652003
165Keratoconjunctivitis (HP:0001096)1.70299827
166Keratoconjunctivitis sicca (HP:0001097)1.68747411
167Asymmetric septal hypertrophy (HP:0001670)1.66636303
168Hemiplegia (HP:0002301)1.65851848
169Meningitis (HP:0001287)1.64963568
170Thoracic kyphosis (HP:0002942)1.63940091
171* Joint stiffness (HP:0001387)1.62024726
172Opisthotonus (HP:0002179)1.60107324
173Hepatosplenomegaly (HP:0001433)1.59533456
174Ovoid vertebral bodies (HP:0003300)1.59240759
175Encephalitis (HP:0002383)1.59014224
1763-Methylglutaconic aciduria (HP:0003535)1.58920209
177Increased CSF protein (HP:0002922)1.58476881
178Vasculitis (HP:0002633)1.58251906
179Increased IgM level (HP:0003496)1.57541392

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.25301654
2MAPK154.16715074
3NTRK33.73538357
4MAP3K112.75681424
5TNIK2.63056947
6CASK2.61006010
7ARAF2.48039575
8WNK32.27830627
9MAP3K92.27130202
10EPHA42.20775979
11WNK42.18951934
12NME22.07287301
13TBK12.05010763
14MAP4K12.04384696
15BLK1.93994784
16PRKD31.92697410
17RIPK41.81028942
18CAMKK21.80526618
19MAP3K131.76066874
20IRAK41.74145738
21TXK1.73374120
22IKBKB1.71582115
23ABL21.68385315
24HIPK21.66584586
25UHMK11.66277933
26TNK21.62591759
27PASK1.60322967
28OXSR11.58144141
29MAP3K21.51707606
30STK161.51676948
31SGK4941.50845559
32SGK2231.50845559
33MAP2K71.50196900
34LIMK11.49749912
35NTRK11.46343503
36MAP2K61.45966307
37KIT1.45066979
38TESK21.44329918
39IKBKE1.44259912
40PIM21.43968695
41BRAF1.43533223
42MAP3K121.42710076
43IRAK11.41967005
44TYK21.41401672
45PRPF4B1.38150815
46TGFBR21.36855357
47MAP3K141.32996403
48ZAP701.32837737
49TLK11.32001430
50MARK11.29217377
51AKT31.27525231
52CAMK2B1.22056695
53NTRK21.21907671
54CDK191.21653407
55SYK1.17819011
56MAP2K31.16890066
57PRKCG1.15504486
58DDR21.14055034
59TESK11.13725341
60CDC42BPA1.13112452
61KSR21.11554946
62TAOK21.11520061
63MINK11.08573543
64CDK51.08561335
65GRK51.08232245
66MAP3K41.08046605
67MATK1.06243977
68IRAK21.03992316
69DAPK21.03719492
70NEK61.03592404
71TAOK11.02944721
72ACVR1B1.02606222
73MAP3K11.02011713
74MAPKAPK31.01764978
75CSK1.01754313
76PINK11.00004024
77CSF1R0.99243158
78GRK60.99175531
79MAP3K30.97082723
80MAPK130.95646607
81BCKDK0.94402581
82SGK20.92363901
83PRKCH0.88031425
84LYN0.87273250
85NME10.86297862
86PRKCE0.85742744
87TAOK30.85554327
88CAMK2A0.85229768
89STK390.84746460
90DYRK1A0.83836372
91MUSK0.83597604
92CAMK2D0.82564458
93BMPR1B0.82562081
94PAK60.81819504
95FGR0.80757712
96PRKD20.80589919
97JAK30.80091182
98STK380.80052787
99BMPR20.77839381
100PIK3CG0.77571178
101RIPK10.77077060
102CSNK1G20.75521953
103CDK30.75104896
104MAPK120.74622290
105TYRO30.74172817
106CAMK2G0.73584581
107HCK0.73473008
108MAP2K20.73276150
109MAP2K40.73266776
110LCK0.72273111
111FES0.67530855
112PAK30.67054016
113PKN10.66727398
114PRKG20.65445326
115ITK0.65380835
116BTK0.64455612
117KDR0.63394452
118DAPK10.63011187
119RPS6KA60.62016085
120CSNK1G30.61865995
121CHUK0.60392690
122IRAK30.59573454
123SIK20.59532312
124MAPKAPK50.59213872
125NLK0.58202613
126ADRBK20.58072824
127BCR0.56368315
128PHKG10.56298201
129PHKG20.56298201
130PDK10.55136886
131TIE10.53411613
132CAMKK10.53310413
133MARK30.53294379
134EPHA30.52991012
135GRK70.52757127
136VRK10.52623222
137EIF2AK30.52465457
138WNK10.52248900
139PRKCQ0.52007622
140RPS6KA20.50977994
141ERN10.50790382
142RAF10.50754871
143CDK140.50632437
144JAK20.50092701
145MARK20.50059253
146GRK10.49383182
147CSNK1A1L0.49261915
148RPS6KL10.49204094
149RPS6KC10.49204094
150MAPK70.48494771
151CSNK1A10.47938890
152PRKACA0.47011392
153FRK0.46248579
154CCNB10.45636324
155SCYL20.45605139
156PNCK0.45465025
157TSSK60.45147232
158CSNK1G10.44894912
159JAK10.43368079
160CAMK10.43198882
161MOS0.42279704
162MAPK40.42127799
163PTK2B0.42110181
164PDPK10.41820621
165ADRBK10.41094003

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.72591418
2Protein export_Homo sapiens_hsa030604.02742779
3Synaptic vesicle cycle_Homo sapiens_hsa047212.85956955
4Insulin secretion_Homo sapiens_hsa049112.81539548
5Staphylococcus aureus infection_Homo sapiens_hsa051502.63338436
6Collecting duct acid secretion_Homo sapiens_hsa049662.54005014
7Vibrio cholerae infection_Homo sapiens_hsa051102.37540993
8Nicotine addiction_Homo sapiens_hsa050332.37417482
9GABAergic synapse_Homo sapiens_hsa047272.22358992
10Sulfur metabolism_Homo sapiens_hsa009202.18635712
11Asthma_Homo sapiens_hsa053102.17105470
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.14615643
13Allograft rejection_Homo sapiens_hsa053302.12814690
14Graft-versus-host disease_Homo sapiens_hsa053322.06529621
15Amphetamine addiction_Homo sapiens_hsa050312.01008169
16Osteoclast differentiation_Homo sapiens_hsa043801.96593685
17Cocaine addiction_Homo sapiens_hsa050301.94815399
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.93709299
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.87271005
20Taste transduction_Homo sapiens_hsa047421.82935727
21Circadian entrainment_Homo sapiens_hsa047131.82186758
22Morphine addiction_Homo sapiens_hsa050321.80904893
23Leishmaniasis_Homo sapiens_hsa051401.78520743
24Autoimmune thyroid disease_Homo sapiens_hsa053201.77827277
25Olfactory transduction_Homo sapiens_hsa047401.67106916
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67098748
27Oxidative phosphorylation_Homo sapiens_hsa001901.66244059
28Dopaminergic synapse_Homo sapiens_hsa047281.59847861
29Glutamatergic synapse_Homo sapiens_hsa047241.59197271
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.58195675
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.57687424
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.56014094
33Pertussis_Homo sapiens_hsa051331.55780520
34Long-term potentiation_Homo sapiens_hsa047201.55495226
35Phototransduction_Homo sapiens_hsa047441.54651637
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.51813878
37Malaria_Homo sapiens_hsa051441.50762967
38Tuberculosis_Homo sapiens_hsa051521.50359418
39Other glycan degradation_Homo sapiens_hsa005111.47013117
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.46783589
41Serotonergic synapse_Homo sapiens_hsa047261.46489570
42Pancreatic secretion_Homo sapiens_hsa049721.45182978
43Regulation of autophagy_Homo sapiens_hsa041401.40778323
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.35930345
45NF-kappa B signaling pathway_Homo sapiens_hsa040641.34750473
46Antigen processing and presentation_Homo sapiens_hsa046121.34344399
47* Lysosome_Homo sapiens_hsa041421.32597670
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31025974
49NOD-like receptor signaling pathway_Homo sapiens_hsa046211.30985155
50Type I diabetes mellitus_Homo sapiens_hsa049401.30317675
51Cholinergic synapse_Homo sapiens_hsa047251.24322619
52Folate biosynthesis_Homo sapiens_hsa007901.21548693
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.20109279
54TNF signaling pathway_Homo sapiens_hsa046681.18633131
55Primary immunodeficiency_Homo sapiens_hsa053401.18319713
56Aldosterone synthesis and secretion_Homo sapiens_hsa049251.17882730
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17743507
58Circadian rhythm_Homo sapiens_hsa047101.17616355
59Sphingolipid metabolism_Homo sapiens_hsa006001.15665220
60N-Glycan biosynthesis_Homo sapiens_hsa005101.14198458
61Salivary secretion_Homo sapiens_hsa049701.12531456
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10498404
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10285300
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09526087
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08059204
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06287926
67Parkinsons disease_Homo sapiens_hsa050121.06010087
68Gastric acid secretion_Homo sapiens_hsa049711.05471093
69Butanoate metabolism_Homo sapiens_hsa006501.04873937
70Type II diabetes mellitus_Homo sapiens_hsa049301.04835579
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03626169
72Alzheimers disease_Homo sapiens_hsa050101.02867323
73Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01545344
74Hematopoietic cell lineage_Homo sapiens_hsa046400.99541430
75Complement and coagulation cascades_Homo sapiens_hsa046100.97139514
76African trypanosomiasis_Homo sapiens_hsa051430.96055522
77Tryptophan metabolism_Homo sapiens_hsa003800.94932536
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.94304073
79Arachidonic acid metabolism_Homo sapiens_hsa005900.93734190
80Renin secretion_Homo sapiens_hsa049240.92794536
81Long-term depression_Homo sapiens_hsa047300.90438682
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88076330
83Toxoplasmosis_Homo sapiens_hsa051450.84471814
84Salmonella infection_Homo sapiens_hsa051320.83803289
85PPAR signaling pathway_Homo sapiens_hsa033200.82869983
86Thyroid hormone synthesis_Homo sapiens_hsa049180.82734433
87Legionellosis_Homo sapiens_hsa051340.76935736
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76329393
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76308561
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75988898
91Calcium signaling pathway_Homo sapiens_hsa040200.74565833
92Fatty acid elongation_Homo sapiens_hsa000620.71863178
93cAMP signaling pathway_Homo sapiens_hsa040240.71032415
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.70899265
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69673772
96Chemokine signaling pathway_Homo sapiens_hsa040620.69114863
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68469901
98Rheumatoid arthritis_Homo sapiens_hsa053230.66146689
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64591231
100Ether lipid metabolism_Homo sapiens_hsa005650.63789192
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.62793999
102Prion diseases_Homo sapiens_hsa050200.61052748
103Vitamin B6 metabolism_Homo sapiens_hsa007500.60259271
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56181081
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55489039
106Huntingtons disease_Homo sapiens_hsa050160.54565041
107Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54549978
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.54075202
109Chemical carcinogenesis_Homo sapiens_hsa052040.53591676
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.53192644
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50795148
112Nitrogen metabolism_Homo sapiens_hsa009100.50423376
113Glycerolipid metabolism_Homo sapiens_hsa005610.49924861
114Ovarian steroidogenesis_Homo sapiens_hsa049130.48605461
115Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47533012
116Estrogen signaling pathway_Homo sapiens_hsa049150.47283603
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45755316
118T cell receptor signaling pathway_Homo sapiens_hsa046600.45515518
119B cell receptor signaling pathway_Homo sapiens_hsa046620.45272038
120Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44441323
121Cardiac muscle contraction_Homo sapiens_hsa042600.44167149
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.44151485
123GnRH signaling pathway_Homo sapiens_hsa049120.44072985
124Oxytocin signaling pathway_Homo sapiens_hsa049210.43980297
125Viral myocarditis_Homo sapiens_hsa054160.43848419
126Caffeine metabolism_Homo sapiens_hsa002320.43647827
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42471207
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42386079
129Influenza A_Homo sapiens_hsa051640.42027889
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41868517
131Glucagon signaling pathway_Homo sapiens_hsa049220.40921387
132Gap junction_Homo sapiens_hsa045400.40768109
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39485077
134Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39012347
135Jak-STAT signaling pathway_Homo sapiens_hsa046300.38786642
136Inositol phosphate metabolism_Homo sapiens_hsa005620.37920256
137Sulfur relay system_Homo sapiens_hsa041220.37733279
138Alcoholism_Homo sapiens_hsa050340.36445414
139Melanogenesis_Homo sapiens_hsa049160.35929089
140Steroid hormone biosynthesis_Homo sapiens_hsa001400.35349582
141Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35107306
142Linoleic acid metabolism_Homo sapiens_hsa005910.33952161
143Metabolic pathways_Homo sapiens_hsa011000.30801481
144Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29440267
145Mineral absorption_Homo sapiens_hsa049780.28114071
146ABC transporters_Homo sapiens_hsa020100.27705560
147Histidine metabolism_Homo sapiens_hsa003400.27057263
148Choline metabolism in cancer_Homo sapiens_hsa052310.26471424
149Phagosome_Homo sapiens_hsa041450.25430075
150alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25236582
151Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24131031
152Peroxisome_Homo sapiens_hsa041460.22503314
153Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.22208895

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