GNMT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. This protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia). Alternative splicing results in multiple transcript variants. Naturally occurring readthrough transcription occurs between the upstream CNPY3 (canopy FGF signaling regulator 3) gene and this gene and is represented with GeneID:107080644. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)9.48541135
2omega-hydroxylase P450 pathway (GO:0097267)9.20039457
3epoxygenase P450 pathway (GO:0019373)9.12179459
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.71363632
5L-phenylalanine catabolic process (GO:0006559)7.71363632
6L-phenylalanine metabolic process (GO:0006558)7.37846969
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.37846969
8aromatic amino acid family catabolic process (GO:0009074)6.92403875
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.31841721
10drug metabolic process (GO:0017144)6.24429980
11tryptophan catabolic process (GO:0006569)6.23727234
12indole-containing compound catabolic process (GO:0042436)6.23727234
13indolalkylamine catabolic process (GO:0046218)6.23727234
14oxidative demethylation (GO:0070989)6.08575241
15kynurenine metabolic process (GO:0070189)6.08093530
16ethanol metabolic process (GO:0006067)6.02463510
17bile acid biosynthetic process (GO:0006699)5.98665946
18tryptophan metabolic process (GO:0006568)5.89543394
19urea metabolic process (GO:0019627)5.81051500
20urea cycle (GO:0000050)5.81051500
21glyoxylate metabolic process (GO:0046487)5.79148333
22high-density lipoprotein particle remodeling (GO:0034375)5.59034217
23negative regulation of fibrinolysis (GO:0051918)5.58304367
24regulation of plasminogen activation (GO:0010755)5.56494837
25cysteine metabolic process (GO:0006534)5.49041155
26alpha-linolenic acid metabolic process (GO:0036109)5.48080761
27sulfur amino acid catabolic process (GO:0000098)5.45223463
28regulation of fibrinolysis (GO:0051917)5.37509701
29peptidyl-glutamic acid carboxylation (GO:0017187)5.35067629
30protein carboxylation (GO:0018214)5.35067629
31nitrogen cycle metabolic process (GO:0071941)5.34710552
32phenylpropanoid metabolic process (GO:0009698)5.33896709
33complement activation, alternative pathway (GO:0006957)5.30200386
34regulation of protein activation cascade (GO:2000257)5.28216643
35serine family amino acid catabolic process (GO:0009071)5.21342806
36opsonization (GO:0008228)5.15991050
37bile acid metabolic process (GO:0008206)5.10123901
38aromatic amino acid family metabolic process (GO:0009072)5.04554864
39homocysteine metabolic process (GO:0050667)4.94826320
40regulation of complement activation (GO:0030449)4.92743112
41tyrosine metabolic process (GO:0006570)4.92190229
42regulation of cholesterol esterification (GO:0010872)4.89046101
43reverse cholesterol transport (GO:0043691)4.84868184
44regulation of triglyceride catabolic process (GO:0010896)4.84476959
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.83898083
46plasma lipoprotein particle remodeling (GO:0034369)4.77004333
47protein-lipid complex remodeling (GO:0034368)4.77004333
48macromolecular complex remodeling (GO:0034367)4.77004333
49alpha-amino acid catabolic process (GO:1901606)4.73318984
50acute-phase response (GO:0006953)4.66732782
51lysine catabolic process (GO:0006554)4.64635972
52lysine metabolic process (GO:0006553)4.64635972
53alkaloid metabolic process (GO:0009820)4.62144284
54regulation of humoral immune response (GO:0002920)4.61527799
55amino-acid betaine metabolic process (GO:0006577)4.61344764
56killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.61073482
57disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.61073482
58triglyceride homeostasis (GO:0070328)4.59165190
59acylglycerol homeostasis (GO:0055090)4.59165190
60negative regulation of cholesterol transport (GO:0032375)4.56400843
61negative regulation of sterol transport (GO:0032372)4.56400843
62phospholipid efflux (GO:0033700)4.55898414
63negative regulation of blood coagulation (GO:0030195)4.53712877
64negative regulation of hemostasis (GO:1900047)4.53712877
65glycine metabolic process (GO:0006544)4.49276994
66coenzyme catabolic process (GO:0009109)4.48107330
67indolalkylamine metabolic process (GO:0006586)4.43883234
68imidazole-containing compound metabolic process (GO:0052803)4.41968822
69cellular ketone body metabolic process (GO:0046950)4.39558562
70bile acid and bile salt transport (GO:0015721)4.38321478
71plasma lipoprotein particle clearance (GO:0034381)4.35731017
72cellular amino acid catabolic process (GO:0009063)4.35726855
73amine catabolic process (GO:0009310)4.33259368
74cellular biogenic amine catabolic process (GO:0042402)4.33259368
75glutamate metabolic process (GO:0006536)4.29929815
76serine family amino acid metabolic process (GO:0009069)4.26575618
77negative regulation of protein activation cascade (GO:2000258)4.25814306
78cellular glucuronidation (GO:0052695)4.24275740
79cholesterol efflux (GO:0033344)4.18279098
80cellular modified amino acid catabolic process (GO:0042219)4.16795252
81benzene-containing compound metabolic process (GO:0042537)4.15174286
82ethanol oxidation (GO:0006069)4.12871548
83positive regulation of hemostasis (GO:1900048)4.12188916
84positive regulation of blood coagulation (GO:0030194)4.12188916
85serine family amino acid biosynthetic process (GO:0009070)4.11876113
86arginine metabolic process (GO:0006525)4.11575897
87negative regulation of coagulation (GO:0050819)4.08823179
88aldehyde catabolic process (GO:0046185)4.05173127
89negative regulation of wound healing (GO:0061045)4.04956780
90dicarboxylic acid biosynthetic process (GO:0043650)4.03347730
91low-density lipoprotein particle remodeling (GO:0034374)4.01961866
92fibrinolysis (GO:0042730)3.98049196
93plasma lipoprotein particle assembly (GO:0034377)3.97266529
94intestinal cholesterol absorption (GO:0030299)3.95613503
95* S-adenosylmethionine metabolic process (GO:0046500)3.92014065
96response to mercury ion (GO:0046689)3.89104448
97drug catabolic process (GO:0042737)3.87826513
98cofactor catabolic process (GO:0051187)3.84129399
99blood coagulation, intrinsic pathway (GO:0007597)3.81212559
100ketone body metabolic process (GO:1902224)3.80435789
101carboxylic acid catabolic process (GO:0046395)3.78735862
102organic acid catabolic process (GO:0016054)3.78735862
103positive regulation of coagulation (GO:0050820)3.77859756
104positive regulation of triglyceride lipase activity (GO:0061365)3.76699500
105positive regulation of lipoprotein lipase activity (GO:0051006)3.76699500
106uronic acid metabolic process (GO:0006063)3.76306107
107glucuronate metabolic process (GO:0019585)3.76306107
108negative regulation of lipase activity (GO:0060192)3.76258237
109complement activation, classical pathway (GO:0006958)3.74145139
110regulation of bile acid biosynthetic process (GO:0070857)3.73584035
111very-low-density lipoprotein particle assembly (GO:0034379)3.73148596
112cholesterol homeostasis (GO:0042632)3.71777465
113complement activation (GO:0006956)3.70121694
114positive regulation of lipid catabolic process (GO:0050996)3.69757579
115acetyl-CoA metabolic process (GO:0006084)3.68743049
116phospholipid homeostasis (GO:0055091)3.68605454
117protein activation cascade (GO:0072376)3.68585816
118short-chain fatty acid metabolic process (GO:0046459)3.67946888
119L-serine metabolic process (GO:0006563)3.67477900
120cytolysis (GO:0019835)3.65775340
121sterol homeostasis (GO:0055092)3.65554519
122negative regulation of complement activation (GO:0045916)3.63193273
123regulation of cholesterol homeostasis (GO:2000188)3.61842473
124plasma lipoprotein particle organization (GO:0071827)3.60878351
125NAD biosynthetic process (GO:0009435)3.58606364
126protein-lipid complex assembly (GO:0065005)3.55964486
127hormone catabolic process (GO:0042447)3.55256550
128acute inflammatory response (GO:0002526)3.55007866
129nicotinamide nucleotide biosynthetic process (GO:0019359)3.53885560
130positive regulation of fatty acid biosynthetic process (GO:0045723)3.47015046
131flavonoid metabolic process (GO:0009812)3.42743872
132regulation of apoptotic cell clearance (GO:2000425)3.38763981
133positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.38538825

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.41030056
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.20139445
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.04123165
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.49096169
5* FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.23693055
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.17249371
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.83560293
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.04931967
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.04007382
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08365757
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.00011175
12* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9650941
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98834343
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.59769962
15HTT_18923047_ChIP-ChIP_STHdh_Human1.56245536
16CLOCK_20551151_ChIP-Seq_293T_Human1.53766704
17GATA1_22025678_ChIP-Seq_K562_Human1.41052346
18HNF4A_19822575_ChIP-Seq_HepG2_Human1.40397457
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29479745
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28218977
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27375442
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20015710
23* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.18518408
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16131674
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04012696
26ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02211558
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.01135942
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.96617697
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94529421
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94348328
31SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93172728
32SMC4_20622854_ChIP-Seq_HELA_Human0.89793095
33IRF8_22096565_ChIP-ChIP_GC-B_Human0.86019969
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84935929
35ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84925237
36RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84701451
37DNAJC2_21179169_ChIP-ChIP_NT2_Human0.82636555
38AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82401018
39GATA4_25053715_ChIP-Seq_YYC3_Human0.81482735
40SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81414728
41SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81197300
42SOX2_21211035_ChIP-Seq_LN229_Human0.81120568
43ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.80544663
44ELF1_20517297_ChIP-Seq_JURKAT_Human0.79924549
45SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77815911
46GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.77219902
47KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77194688
48E2F1_20622854_ChIP-Seq_HELA_Human0.76246937
49SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75435694
50SA1_27219007_Chip-Seq_Bcells_Human0.74901455
51* RAC3_21632823_ChIP-Seq_H3396_Human0.74899361
52RARA_24833708_ChIP-Seq_LIVER_Mouse0.74797531
53SPI1_20517297_ChIP-Seq_HL60_Human0.74565747
54BCL6_27268052_Chip-Seq_Bcells_Human0.74565159
55BCOR_27268052_Chip-Seq_Bcells_Human0.74088629
56BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73495981
57ZNF263_19887448_ChIP-Seq_K562_Human0.72175659
58CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.70798049
59CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70614842
60CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70378775
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.70213746
62P68_20966046_ChIP-Seq_HELA_Human0.69363227
63CTCF_27219007_Chip-Seq_Bcells_Human0.68666136
64GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.68624813
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.67905380
66AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67622822
67ESR2_21235772_ChIP-Seq_MCF-7_Human0.66761108
68TET1_21451524_ChIP-Seq_MESCs_Mouse0.65891081
69HNFA_21074721_ChIP-Seq_CACO-2_Human0.65860572
70P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.65359202
71SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65183249
72CTCF_20526341_ChIP-Seq_ESCs_Human0.64400443
73RARB_24833708_ChIP-Seq_LIVER_Mouse0.64373206
74NRF2_20460467_ChIP-Seq_MEFs_Mouse0.63355372
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.63355372
76BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.63089236
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.62379817
78RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62291667
79RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.61922249
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.61907194
81FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.61891257
82GATA6_21074721_ChIP-Seq_CACO-2_Human0.61221515
83NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.60261973
84ETV2_25802403_ChIP-Seq_MESCs_Mouse0.60184960
85P300_27268052_Chip-Seq_Bcells_Human0.59303068
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.59014028
87PHF8_20622853_ChIP-Seq_HELA_Human0.58575253
88CEBPB_22108803_ChIP-Seq_LS180_Human0.57984977
89PHF8_20622854_ChIP-Seq_HELA_Human0.57866607
90JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.57484020
91EGR1_19032775_ChIP-ChIP_M12_Human0.56529985
92SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.56254528
93LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.54557476
94E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.54186392
95POU5F1_16518401_ChIP-PET_MESCs_Mouse0.54063564
96AR_20517297_ChIP-Seq_VCAP_Human0.53615762
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.53527926
98FOXA1_25552417_ChIP-Seq_VCAP_Human0.53336637
99STAT3_1855785_ChIP-Seq_MESCs_Mouse0.53293754
100ERA_21632823_ChIP-Seq_H3396_Human0.53285577
101FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52948237
102PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52681589
103RACK7_27058665_Chip-Seq_MCF-7_Human0.52116207
104* LXR_22292898_ChIP-Seq_THP-1_Human0.52019974
105MYC_19915707_ChIP-ChIP_AK7_Human0.51375772
106FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.51265085
107EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.51200487
108ESET_19884257_ChIP-Seq_ESCs_Mouse0.49842716
109P53_21459846_ChIP-Seq_SAOS-2_Human0.47918000
110CBP_21632823_ChIP-Seq_H3396_Human0.47429009
111STAT1_17558387_ChIP-Seq_HELA_Human0.46644668
112ESR1_21235772_ChIP-Seq_MCF-7_Human0.45205889
113PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44569456
114CDX2_20551321_ChIP-Seq_CACO-2_Human0.44385588
115PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44185211
116TAF15_26573619_Chip-Seq_HEK293_Human0.43736192
117PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43633591
118FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.43555938
119TAF2_19829295_ChIP-Seq_ESCs_Human0.43502054
120SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.43284908
121ERG_21242973_ChIP-ChIP_JURKAT_Human0.42822150
122FOXO3_23340844_ChIP-Seq_DLD1_Human0.41049973
123GATA1_19941827_ChIP-Seq_MEL_Mouse0.40947186
124GATA6_25053715_ChIP-Seq_YYC3_Human0.39739292
125GATA1_19941826_ChIP-Seq_K562_Human0.39715936
126STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.39044838
127* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.38785451
128MYC_27129775_Chip-Seq_CORNEA_Mouse0.38254593
129BCAT_22108803_ChIP-Seq_LS180_Human0.37945436
130GATA2_19941826_ChIP-Seq_K562_Human0.37823553
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.37761804
132PPAR_26484153_Chip-Seq_NCI-H1993_Human0.37731921
133ESR1_20079471_ChIP-ChIP_T-47D_Human0.37360246
134LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35582402
135ERG_20517297_ChIP-Seq_VCAP_Human0.35088463
136NCOR_22424771_ChIP-Seq_293T_Human0.34431358
137FOXH1_21741376_ChIP-Seq_EPCs_Human0.34321243
138SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.33869462
139SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.33605130
140* SPI1_26923725_Chip-Seq_HPCs_Mouse0.33097296
141OCT4_20526341_ChIP-Seq_ESCs_Human0.33089278

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.24547056
2MP0005360_urolithiasis7.54741295
3MP0005085_abnormal_gallbladder_physiolo6.47388097
4MP0005365_abnormal_bile_salt6.25490302
5MP0008875_abnormal_xenobiotic_pharmacok5.11965820
6MP0003806_abnormal_nucleotide_metabolis4.29765350
7MP0003252_abnormal_bile_duct3.88181967
8MP0010329_abnormal_lipoprotein_level3.57655203
9MP0009840_abnormal_foam_cell3.29487791
10MP0005083_abnormal_biliary_tract3.17574219
11MP0003195_calcinosis2.86608520
12* MP0005332_abnormal_amino_acid2.72268123
13MP0001666_abnormal_nutrient_absorption2.70770070
14MP0003191_abnormal_cellular_cholesterol2.30524224
15MP0000609_abnormal_liver_physiology2.15310359
16MP0004019_abnormal_vitamin_homeostasis2.12107403
17* MP0002118_abnormal_lipid_homeostasis2.07918083
18MP0003868_abnormal_feces_composition1.99215444
19MP0002138_abnormal_hepatobiliary_system1.97284175
20* MP0005319_abnormal_enzyme/_coenzyme1.76908545
21MP0001764_abnormal_homeostasis1.71555184
22MP0009697_abnormal_copulation1.62753171
23MP0005584_abnormal_enzyme/coenzyme_acti1.56846523
24MP0005451_abnormal_body_composition1.48665149
25MP0003011_delayed_dark_adaptation1.35667093
26MP0003186_abnormal_redox_activity1.30567986
27MP0009643_abnormal_urine_homeostasis1.24678991
28MP0003656_abnormal_erythrocyte_physiolo1.24031281
29MP0003705_abnormal_hypodermis_morpholog1.17337683
30* MP0000598_abnormal_liver_morphology1.15103218
31MP0005647_abnormal_sex_gland1.13095160
32MP0000604_amyloidosis1.07743960
33MP0009764_decreased_sensitivity_to1.04408833
34MP0009763_increased_sensitivity_to1.01418852
35MP0002254_reproductive_system_inflammat0.98779766
36MP0005636_abnormal_mineral_homeostasis0.93046625
37MP0010368_abnormal_lymphatic_system0.91972952
38MP0002282_abnormal_trachea_morphology0.88497008
39MP0005408_hypopigmentation0.87693054
40* MP0009642_abnormal_blood_homeostasis0.86105472
41* MP0008469_abnormal_protein_level0.85520388
42MP0006036_abnormal_mitochondrial_physio0.83774607
43MP0005220_abnormal_exocrine_pancreas0.83111233
44MP0005084_abnormal_gallbladder_morpholo0.81961294
45MP0005670_abnormal_white_adipose0.80668750
46MP0005376_homeostasis/metabolism_phenot0.80152641
47MP0009765_abnormal_xenobiotic_induced0.79328625
48MP0002249_abnormal_larynx_morphology0.76936112
49MP0002876_abnormal_thyroid_physiology0.76146124
50* MP0002078_abnormal_glucose_homeostasis0.75294038
51MP0002971_abnormal_brown_adipose0.71652739
52MP0005187_abnormal_penis_morphology0.70907940
53MP0003879_abnormal_hair_cell0.70213927
54MP0005334_abnormal_fat_pad0.68904274
55MP0005535_abnormal_body_temperature0.68006873
56MP0009785_altered_susceptibility_to0.67279576
57MP0004130_abnormal_muscle_cell0.66975927
58MP0003690_abnormal_glial_cell0.66650183
59MP0005266_abnormal_metabolism0.65292193
60MP0003329_amyloid_beta_deposits0.65160896
61MP0001661_extended_life_span0.64740842
62MP0009053_abnormal_anal_canal0.64518633
63MP0001915_intracranial_hemorrhage0.63273247
64MP0001756_abnormal_urination0.60630575
65MP0000639_abnormal_adrenal_gland0.59789842
66MP0006035_abnormal_mitochondrial_morpho0.57232108
67MP0005448_abnormal_energy_balance0.56570574
68MP0005464_abnormal_platelet_physiology0.51291691
69MP0003638_abnormal_response/metabolism_0.48943161
70MP0002822_catalepsy0.48868961
71MP0005395_other_phenotype0.48692944
72MP0003718_maternal_effect0.46600204
73MP0008874_decreased_physiological_sensi0.45251801
74MP0002928_abnormal_bile_duct0.44900244
75MP0008873_increased_physiological_sensi0.44762366
76MP0002136_abnormal_kidney_physiology0.44628036
77MP0004782_abnormal_surfactant_physiolog0.43541351
78MP0003436_decreased_susceptibility_to0.41479924
79MP0003953_abnormal_hormone_level0.41037629
80MP0002837_dystrophic_cardiac_calcinosis0.40577395
81MP0004381_abnormal_hair_follicle0.40156021
82MP0003724_increased_susceptibility_to0.40028102
83MP0003075_altered_response_to0.39676272
84MP0005248_abnormal_Harderian_gland0.39306679
85MP0008872_abnormal_physiological_respon0.39246300
86MP0005023_abnormal_wound_healing0.38381540
87MP0005166_decreased_susceptibility_to0.37300859
88MP0005666_abnormal_adipose_tissue0.36374227
89MP0009672_abnormal_birth_weight0.36371810
90MP0005164_abnormal_response_to0.35853466
91MP0000467_abnormal_esophagus_morphology0.35372162
92MP0000579_abnormal_nail_morphology0.34722016
93MP0001851_eye_inflammation0.34117659
94MP0002796_impaired_skin_barrier0.33214217
95MP0009115_abnormal_fat_cell0.31719892
96MP0000230_abnormal_systemic_arterial0.31685818
97MP0002168_other_aberrant_phenotype0.31296834
98MP0009384_cardiac_valve_regurgitation0.31265418
99MP0001243_abnormal_dermal_layer0.31154862
100MP0000249_abnormal_blood_vessel0.31104233
101MP0002970_abnormal_white_adipose0.30541759
102MP0006082_CNS_inflammation0.29872337
103MP0002332_abnormal_exercise_endurance0.29792125
104MP0002419_abnormal_innate_immunity0.29304010
105MP0004883_abnormal_blood_vessel0.28977416
106MP0001845_abnormal_inflammatory_respons0.28016723
107MP0001853_heart_inflammation0.27996673
108MP0005025_abnormal_response_to0.27507678
109MP0001881_abnormal_mammary_gland0.27261664
110MP0002132_abnormal_respiratory_system0.26071781
111MP0002060_abnormal_skin_morphology0.24620477
112MP0002090_abnormal_vision0.23532697
113MP0005058_abnormal_lysosome_morphology0.23133925
114MP0000858_altered_metastatic_potential0.22535636
115MP0010155_abnormal_intestine_physiology0.22409317
116MP0000566_synostosis0.22207849
117MP0001944_abnormal_pancreas_morphology0.21966743
118MP0005375_adipose_tissue_phenotype0.21749778
119MP0003959_abnormal_lean_body0.18974496

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.57766882
2Deep venous thrombosis (HP:0002625)7.39835967
3Intrahepatic cholestasis (HP:0001406)7.30099041
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.84830542
5Prolonged partial thromboplastin time (HP:0003645)6.54750038
6Hypobetalipoproteinemia (HP:0003563)6.43819785
7Xanthomatosis (HP:0000991)6.29796893
8Hyperlipoproteinemia (HP:0010980)5.65022294
9Complement deficiency (HP:0004431)5.34169555
10Hypolipoproteinemia (HP:0010981)4.79671801
11Joint hemorrhage (HP:0005261)4.79191402
12Hyperammonemia (HP:0001987)4.67526087
13Epidermoid cyst (HP:0200040)4.52295453
14Hyperglycinemia (HP:0002154)4.47156493
15Abnormality of the common coagulation pathway (HP:0010990)4.45451243
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.39258539
17Ketosis (HP:0001946)4.30755074
18Abnormality of glutamine family amino acid metabolism (HP:0010902)4.23069793
19Hypoalphalipoproteinemia (HP:0003233)4.19248217
20Fat malabsorption (HP:0002630)4.18004686
21* Abnormality of sulfur amino acid metabolism (HP:0004339)4.02133950
22Abnormality of pyrimidine metabolism (HP:0004353)3.98549852
23Hyperglycinuria (HP:0003108)3.98358647
24Abnormality of serine family amino acid metabolism (HP:0010894)3.95400430
25Abnormality of glycine metabolism (HP:0010895)3.95400430
26Abnormality of complement system (HP:0005339)3.89261566
27Nephritis (HP:0000123)3.83676735
28Hypoglycemic coma (HP:0001325)3.82988507
29* Abnormality of methionine metabolism (HP:0010901)3.80274651
30Abnormality of the intrinsic pathway (HP:0010989)3.80003097
31* Abnormality of aspartate family amino acid metabolism (HP:0010899)3.77782439
32Conjugated hyperbilirubinemia (HP:0002908)3.76459907
33Hypercholesterolemia (HP:0003124)3.59456844
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.40274565
35Abnormality of fatty-acid metabolism (HP:0004359)3.35502271
36Hyperbilirubinemia (HP:0002904)3.34976135
37Steatorrhea (HP:0002570)3.20933994
38Abnormality of serum amino acid levels (HP:0003112)3.14825200
39Abnormality of nucleobase metabolism (HP:0010932)3.13136233
40Delayed CNS myelination (HP:0002188)3.12422690
41Neonatal hypoglycemia (HP:0001998)3.09534064
42Ketoacidosis (HP:0001993)3.02901603
43Spontaneous abortion (HP:0005268)3.00944921
44Hepatocellular carcinoma (HP:0001402)2.99312724
45Myocardial infarction (HP:0001658)2.97575554
46Hypochromic microcytic anemia (HP:0004840)2.93358194
47Metabolic acidosis (HP:0001942)2.81496116
48Skin nodule (HP:0200036)2.79378133
49Pulmonary embolism (HP:0002204)2.78602367
50Purpura (HP:0000979)2.74346486
51Abnormality of purine metabolism (HP:0004352)2.70429424
52Systemic lupus erythematosus (HP:0002725)2.70238300
53Lethargy (HP:0001254)2.66368190
54Vascular calcification (HP:0004934)2.65167044
55Dicarboxylic aciduria (HP:0003215)2.59429021
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.59429021
57Gout (HP:0001997)2.53313329
58Cerebral edema (HP:0002181)2.52065399
59Spastic diplegia (HP:0001264)2.51316820
60Acanthocytosis (HP:0001927)2.49860268
61Fair hair (HP:0002286)2.47213979
62Hypoglycemic seizures (HP:0002173)2.45578317
63Abnormal gallbladder morphology (HP:0012437)2.44938870
64Mitral stenosis (HP:0001718)2.43521169
65Glomerulonephritis (HP:0000099)2.40987191
66Neonatal onset (HP:0003623)2.39651628
67Cholelithiasis (HP:0001081)2.38489777
68Irritability (HP:0000737)2.38315714
69Cardiovascular calcification (HP:0011915)2.34951912
70Recurrent gram-negative bacterial infections (HP:0005420)2.32632045
71Amyloidosis (HP:0011034)2.30351942
72Cholecystitis (HP:0001082)2.29596744
73Abnormal gallbladder physiology (HP:0012438)2.29596744
74Malnutrition (HP:0004395)2.27158825
75Reduced antithrombin III activity (HP:0001976)2.25179338
76Esophageal varix (HP:0002040)2.20104749
77Gingival bleeding (HP:0000225)2.19259566
78Osteomalacia (HP:0002749)2.19252856
79Pancreatitis (HP:0001733)2.18242373
80Menorrhagia (HP:0000132)2.15293354
81Brushfield spots (HP:0001088)2.14965370
82Sensorimotor neuropathy (HP:0007141)2.13898826
83Late onset (HP:0003584)2.12378886
84Enlarged kidneys (HP:0000105)2.12309196
85Vomiting (HP:0002013)2.10972555
86Gangrene (HP:0100758)2.08245071
87Elevated alkaline phosphatase (HP:0003155)2.07860376
88Thrombophlebitis (HP:0004418)2.07817857
89Opisthotonus (HP:0002179)2.06569944
90Generalized aminoaciduria (HP:0002909)2.03316698
91Abnormality of the gallbladder (HP:0005264)1.99048513
92Increased serum ferritin (HP:0003281)1.98909657
93Epistaxis (HP:0000421)1.98010156
94Hemorrhage of the eye (HP:0011885)1.97593427
95Hyperinsulinemic hypoglycemia (HP:0000825)1.97396728
96Poikilocytosis (HP:0004447)1.96216356
97Alkalosis (HP:0001948)1.94825182
98Rickets (HP:0002748)1.91677564
99Abnormality of iron homeostasis (HP:0011031)1.90561447
100Abnormality of transition element cation homeostasis (HP:0011030)1.89594418
101Abnormality of alkaline phosphatase activity (HP:0004379)1.89549786
102Abnormal cartilage morphology (HP:0002763)1.88421836
103Hyperphosphaturia (HP:0003109)1.86734989
104Hypophosphatemic rickets (HP:0004912)1.85950280
105Abnormality of proline metabolism (HP:0010907)1.84786034
106Hydroxyprolinuria (HP:0003080)1.84786034
107Renal cortical cysts (HP:0000803)1.84378469
108Status epilepticus (HP:0002133)1.81500166
109Abnormality of the Achilles tendon (HP:0005109)1.80337761
110Abnormal enzyme/coenzyme activity (HP:0012379)1.79526584
111Generalized hypopigmentation of hair (HP:0011358)1.76255095
112Abnormality of vitamin metabolism (HP:0100508)1.73450465
113* Elevated hepatic transaminases (HP:0002910)1.72526229
114Hyperglycemia (HP:0003074)1.72411244
115Joint swelling (HP:0001386)1.71949821
116Acute hepatic failure (HP:0006554)1.71637870
117Atrioventricular block (HP:0001678)1.70640479
118Increased mean platelet volume (HP:0011877)1.68346187
119Bifid scrotum (HP:0000048)1.67734793
120Cerebral palsy (HP:0100021)1.66960930
121Arthropathy (HP:0003040)1.64601955
122Abnormality of urine glucose concentration (HP:0011016)1.60306917
123Glycosuria (HP:0003076)1.60306917
124Abnormal platelet volume (HP:0011876)1.58767117
125Reticulocytosis (HP:0001923)1.58298709
126Impaired platelet aggregation (HP:0003540)1.56879835
127Abnormal platelet function (HP:0011869)1.56879835
128Anorexia (HP:0002039)1.53915323
129Abnormal urine phosphate concentration (HP:0012599)1.53640720
130Blue irides (HP:0000635)1.45082647

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.46090597
2FGFR44.54414087
3ERN14.53382306
4SIK14.51482058
5TAOK33.04614888
6INSRR2.93515255
7ERBB42.85995090
8PRPF4B2.64841995
9MAP2K42.30080709
10PKN22.28243552
11SMG12.22698209
12TNK22.18648375
13MST1R2.01553767
14FLT31.93877044
15MAPK111.85062564
16PIK3CG1.82093429
17TRIB31.78110091
18TYK21.67778947
19LATS11.60253995
20DAPK21.52934823
21ABL21.47955085
22PTK61.46939575
23FRK1.44073016
24TESK21.43343350
25CAMKK21.38905381
26FGFR21.35351420
27CCNB11.33876914
28CAMKK11.32900898
29NEK91.32149830
30MAP4K11.30603915
31KDR1.25298881
32JAK21.20343535
33PINK11.19956248
34BRSK21.18495675
35MAP3K71.17893630
36MAP2K31.10111024
37PRKAA21.08612355
38GRK61.06955892
39TBK11.04428830
40ERBB21.00458930
41ZAP700.99268277
42JAK10.97484299
43MAPK40.95485690
44MAP3K100.95252685
45MAPK150.94973120
46MAP3K140.94509029
47KSR20.93508065
48MAP3K30.93369530
49PRKCZ0.91934730
50BLK0.91223679
51STK38L0.89873675
52MAPK120.82582134
53MARK20.82458835
54MAP3K110.82400178
55ARAF0.81485085
56PDK20.81276360
57MET0.81102140
58EPHB10.80736201
59CDK60.79192870
60NTRK30.78780874
61EPHA20.75861443
62TIE10.74942444
63PRKACG0.74529775
64MAP2K60.73438032
65EPHA30.73361976
66CAMK2G0.72123721
67CAMK1G0.71457790
68DYRK1B0.71257051
69FER0.70667333
70CSK0.67800217
71IRAK30.66523846
72GSK3A0.65422057
73PRKAA10.65010952
74TAOK10.63969554
75CAMK1D0.63017732
76SGK30.60214102
77RAF10.59878829
78TAOK20.59342227
79MAPK70.59023088
80LRRK20.57549532
81PTK20.55471915
82TGFBR20.55449522
83RIPK10.55441591
84FGFR30.54620417
85IKBKE0.53651448
86CSF1R0.53638702
87RIPK40.53485393
88PDPK10.52227663
89JAK30.52135502
90SIK30.51798731
91PRKCQ0.51091603
92CHUK0.50143553
93CSNK1G10.49929813
94NLK0.49242662
95MAP3K20.48943245
96MAP3K50.46038517
97GRK10.45421763
98MAP2K10.45255035
99IRAK40.44495315
100EPHA40.44213378
101PRKG10.43786962
102SGK20.43134811
103TESK10.43103367
104IGF1R0.42929247
105SGK10.40904074
106RET0.40484830
107CDK40.39728377
108PRKCG0.39363770
109PRKD10.39044672
110PKN10.38707950
111MAP3K130.36647611
112MTOR0.36012879
113EEF2K0.34972327
114ICK0.34686763
115NEK60.34178159
116MAP3K60.33662764
117EGFR0.32790031
118PDK10.32233114
119CAMK40.32171272
120CSNK1G20.32005432
121MAP2K20.31967099
122* PRKACA0.30828748
123SGK2230.30268862
124SGK4940.30268862
125DYRK1A0.30043734
126HCK0.29474745
127CSNK1G30.29434439
128PBK0.28567998
129FES0.27784038
130IRAK20.27625240
131MAPK30.27177719
132MAP3K10.26146517
133PRKCA0.25393087
134IRAK10.24943489
135LATS20.23189644
136PIK3CA0.22786674
137PDK30.20980029
138PDK40.20980029
139ABL10.20284847
140CSNK1A1L0.20193200

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.55131252
2Nitrogen metabolism_Homo sapiens_hsa009103.58417531
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.44842307
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33964898
5Arginine biosynthesis_Homo sapiens_hsa002203.14709223
6Complement and coagulation cascades_Homo sapiens_hsa046102.73237080
7Tryptophan metabolism_Homo sapiens_hsa003802.68251608
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.63154350
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62197546
10* Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.48341046
11Fatty acid degradation_Homo sapiens_hsa000712.45855125
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.38667881
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24132975
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14749366
15Butanoate metabolism_Homo sapiens_hsa006502.10780681
16Peroxisome_Homo sapiens_hsa041462.07264908
17Chemical carcinogenesis_Homo sapiens_hsa052041.96265007
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.93803813
19Propanoate metabolism_Homo sapiens_hsa006401.92524227
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.91618029
21Histidine metabolism_Homo sapiens_hsa003401.91053923
22PPAR signaling pathway_Homo sapiens_hsa033201.83477574
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.78888509
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.77646021
25Fatty acid metabolism_Homo sapiens_hsa012121.75612170
26Caffeine metabolism_Homo sapiens_hsa002321.75148220
27Staphylococcus aureus infection_Homo sapiens_hsa051501.72546140
28beta-Alanine metabolism_Homo sapiens_hsa004101.70438153
29Retinol metabolism_Homo sapiens_hsa008301.69306571
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65855829
31Selenocompound metabolism_Homo sapiens_hsa004501.61016616
32Phenylalanine metabolism_Homo sapiens_hsa003601.59185007
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55283310
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55242048
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53783873
36Bile secretion_Homo sapiens_hsa049761.47106507
37Tyrosine metabolism_Homo sapiens_hsa003501.45787377
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.38386202
39Sulfur metabolism_Homo sapiens_hsa009201.37545623
40Pyruvate metabolism_Homo sapiens_hsa006201.35325956
41Fatty acid elongation_Homo sapiens_hsa000621.30383319
42Starch and sucrose metabolism_Homo sapiens_hsa005001.27690754
43Folate biosynthesis_Homo sapiens_hsa007901.26536988
44Biosynthesis of amino acids_Homo sapiens_hsa012301.24735416
45Steroid biosynthesis_Homo sapiens_hsa001001.20761485
46Fat digestion and absorption_Homo sapiens_hsa049751.18781757
47ABC transporters_Homo sapiens_hsa020101.17151167
48Carbon metabolism_Homo sapiens_hsa012001.12433857
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07195769
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.02534227
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.02109354
52Arginine and proline metabolism_Homo sapiens_hsa003300.98484520
53Sulfur relay system_Homo sapiens_hsa041220.97179618
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96287771
55Vitamin B6 metabolism_Homo sapiens_hsa007500.94020994
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87813807
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84981681
58Vitamin digestion and absorption_Homo sapiens_hsa049770.84556073
59Lysine degradation_Homo sapiens_hsa003100.79475327
60One carbon pool by folate_Homo sapiens_hsa006700.77997215
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69844434
62Glycerolipid metabolism_Homo sapiens_hsa005610.68868393
63Glutathione metabolism_Homo sapiens_hsa004800.66160227
64Pentose phosphate pathway_Homo sapiens_hsa000300.56028049
65Fatty acid biosynthesis_Homo sapiens_hsa000610.50984295
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48196754
67Metabolic pathways_Homo sapiens_hsa011000.46866141
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39227261
69Pertussis_Homo sapiens_hsa051330.38176961
70Prion diseases_Homo sapiens_hsa050200.35927987
71Galactose metabolism_Homo sapiens_hsa000520.25423341
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24742705
73Fructose and mannose metabolism_Homo sapiens_hsa000510.24394778
74Linoleic acid metabolism_Homo sapiens_hsa005910.22870468
75Insulin resistance_Homo sapiens_hsa049310.22219553
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.20835467
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17706882
78Other glycan degradation_Homo sapiens_hsa005110.17161478
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.15875722
80Glucagon signaling pathway_Homo sapiens_hsa049220.08961015
81AMPK signaling pathway_Homo sapiens_hsa041520.01448903
82Ether lipid metabolism_Homo sapiens_hsa00565-0.2480328
83Amoebiasis_Homo sapiens_hsa05146-0.2448193
84Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.2439731
85Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2419432
86Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2401489
87Type II diabetes mellitus_Homo sapiens_hsa04930-0.2351017
88FoxO signaling pathway_Homo sapiens_hsa04068-0.2326135
89Protein digestion and absorption_Homo sapiens_hsa04974-0.2304333
90Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2219799
91Sphingolipid metabolism_Homo sapiens_hsa00600-0.2158679
92Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1970895
93Hepatitis C_Homo sapiens_hsa05160-0.1857381
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1828576
95Renin-angiotensin system_Homo sapiens_hsa04614-0.1724043
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1713669
97Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1597790
98Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1592579
99Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1551418
100Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1538497
101African trypanosomiasis_Homo sapiens_hsa05143-0.1517895
102Circadian rhythm_Homo sapiens_hsa04710-0.1495549
103Regulation of autophagy_Homo sapiens_hsa04140-0.1179059
104Insulin signaling pathway_Homo sapiens_hsa04910-0.1053849
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0925537
106Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0814321
107Pancreatic secretion_Homo sapiens_hsa04972-0.0729440
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0652230
109Mineral absorption_Homo sapiens_hsa04978-0.0384595
110Serotonergic synapse_Homo sapiens_hsa04726-0.0363132
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0310020

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