GNLY

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine ribonucleoside catabolic process (GO:0046133)9.92260056
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450919.01535362
3DNA deamination (GO:0045006)8.43692641
4cellular response to interleukin-15 (GO:0071350)6.43079364
5regulation of activation of Janus kinase activity (GO:0010533)5.50017552
6response to interleukin-15 (GO:0070672)5.47993847
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.35445012
8T cell migration (GO:0072678)5.31427023
9positive regulation of gamma-delta T cell activation (GO:0046645)5.25907914
10positive regulation of natural killer cell mediated immunity (GO:0002717)5.25401699
11regulation of regulatory T cell differentiation (GO:0045589)5.24673286
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.17778798
13negative regulation of cell killing (GO:0031342)5.17778798
14regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.16091913
15regulation of natural killer cell mediated immunity (GO:0002715)5.16091913
16positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.06283851
17positive T cell selection (GO:0043368)4.92317533
18positive thymic T cell selection (GO:0045059)4.88406909
19positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.85097116
20regulation of gamma-delta T cell differentiation (GO:0045586)4.84290908
21eosinophil chemotaxis (GO:0048245)4.83210433
22pyrimidine nucleoside catabolic process (GO:0046135)4.68312229
23regulation of B cell receptor signaling pathway (GO:0050855)4.67599805
24activated T cell proliferation (GO:0050798)4.55962158
25positive regulation of interleukin-8 secretion (GO:2000484)4.51230727
26regulation of leukocyte mediated cytotoxicity (GO:0001910)4.49948278
27antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.49293731
28negative regulation by host of viral transcription (GO:0043922)4.48702600
29negative regulation of viral genome replication (GO:0045071)4.46423379
30macrophage chemotaxis (GO:0048246)4.45744723
31positive regulation of T cell mediated cytotoxicity (GO:0001916)4.42761240
32negative T cell selection (GO:0043383)4.38968374
33regulation of lymphocyte chemotaxis (GO:1901623)4.37328718
34eosinophil migration (GO:0072677)4.36803919
35regulation of gamma-delta T cell activation (GO:0046643)4.34061258
36positive regulation of B cell differentiation (GO:0045579)4.32591731
37positive regulation of cell killing (GO:0031343)4.29228187
38positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.27892577
39regulation of T cell chemotaxis (GO:0010819)4.27574034
40positive regulation of T cell chemotaxis (GO:0010820)4.27574034
41interferon-gamma production (GO:0032609)4.25250700
42regulation of B cell differentiation (GO:0045577)4.22311327
43positive regulation of monocyte chemotaxis (GO:0090026)4.17396306
44positive regulation of calcium-mediated signaling (GO:0050850)4.16398389
45cytolysis (GO:0019835)4.16211397
46negative regulation of T cell apoptotic process (GO:0070233)4.11961814
47regulation of T cell mediated cytotoxicity (GO:0001914)4.09384338
48antigen processing and presentation of endogenous antigen (GO:0019883)4.08134110
49positive regulation of defense response to virus by host (GO:0002230)4.05980557
50antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.04725799
51regulation of cell killing (GO:0031341)4.03976435
52* cellular defense response (GO:0006968)3.99726472
53lymphocyte chemotaxis (GO:0048247)3.99001488
54regulation of isotype switching to IgG isotypes (GO:0048302)3.92317325
55regulation of alpha-beta T cell proliferation (GO:0046640)3.77443729
56regulation of T cell tolerance induction (GO:0002664)3.76960915
57positive regulation of lymphocyte migration (GO:2000403)3.73865086
58thymic T cell selection (GO:0045061)3.69675735
59negative regulation of B cell proliferation (GO:0030889)3.67474485
60negative thymic T cell selection (GO:0045060)3.65210868
61positive regulation of alpha-beta T cell proliferation (GO:0046641)3.63210244
62regulation of interleukin-12 biosynthetic process (GO:0045075)3.62783398
63T cell selection (GO:0045058)3.56605080
64granulocyte activation (GO:0036230)3.56460613
65leukocyte aggregation (GO:0070486)3.55927379
66lymphocyte migration (GO:0072676)3.55200955
67regulation of interleukin-8 secretion (GO:2000482)3.50816399
68positive regulation of tolerance induction (GO:0002645)3.45738434
69negative regulation of type 2 immune response (GO:0002829)3.42779180
70dendritic cell chemotaxis (GO:0002407)3.40130247
71chemokine-mediated signaling pathway (GO:0070098)3.37564733
72T cell receptor signaling pathway (GO:0050852)3.36779183
73regulation of chronic inflammatory response (GO:0002676)3.31461892
74positive regulation of translational initiation (GO:0045948)3.29949943
75regulation of lymphocyte migration (GO:2000401)3.28416408
76positive regulation of T-helper 1 type immune response (GO:0002827)3.28148009
77regulation of tolerance induction (GO:0002643)3.22121730
78monocyte chemotaxis (GO:0002548)3.21906810
79T cell costimulation (GO:0031295)3.20477639
80neutrophil activation (GO:0042119)3.20122589
81regulation of mononuclear cell migration (GO:0071675)3.18261089
82negative regulation of leukocyte mediated immunity (GO:0002704)3.17855031
83lymphocyte costimulation (GO:0031294)3.16467311
84regulation of macrophage chemotaxis (GO:0010758)3.16138531
85regulation of calcium-mediated signaling (GO:0050848)3.14017613
86positive regulation of T cell migration (GO:2000406)3.11704057
87Arp2/3 complex-mediated actin nucleation (GO:0034314)3.09089279
88antigen receptor-mediated signaling pathway (GO:0050851)3.07656896
89regulation of viral genome replication (GO:0045069)3.07369175
90positive regulation of lymphocyte mediated immunity (GO:0002708)3.06601624
91natural killer cell activation (GO:0030101)3.02875752
92negative regulation of B cell activation (GO:0050869)3.01945271
93regulation of T-helper 1 type immune response (GO:0002825)2.97861824
94positive regulation of T cell mediated immunity (GO:0002711)2.97582271
95negative regulation of viral transcription (GO:0032897)2.97580741
96regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.95999452
97regulation of T cell migration (GO:2000404)2.94284589
98cytidine catabolic process (GO:0006216)11.0807727
99cytidine deamination (GO:0009972)11.0807727
100cytidine metabolic process (GO:0046087)11.0807727

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.49044021
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.54267266
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.40471078
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.31243734
5RUNX_20019798_ChIP-Seq_JUKART_Human3.57151221
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.44195074
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.12494129
8MYB_26560356_Chip-Seq_TH2_Human3.01104544
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.87194282
10STAT4_19710469_ChIP-ChIP_TH1__Mouse2.83727819
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.78948510
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.54305698
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.43360661
14CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.39754232
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.35191648
16LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.28623303
17* GATA3_27048872_Chip-Seq_THYMUS_Human2.24710662
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.17638717
19MYB_26560356_Chip-Seq_TH1_Human2.10959337
20UTX_26944678_Chip-Seq_JUKART_Human2.05617301
21GATA3_26560356_Chip-Seq_TH2_Human2.01929191
22IRF8_27001747_Chip-Seq_BMDM_Mouse1.92012278
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.89962439
24MAF_26560356_Chip-Seq_TH1_Human1.86172537
25MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.84052968
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.83327334
27MAF_26560356_Chip-Seq_TH2_Human1.78678525
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74339654
29LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.70709197
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.66653409
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66430499
32GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.64294088
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48897864
34SPI1_23547873_ChIP-Seq_NB4_Human1.47161809
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41235407
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41068382
37* BCL6_27268052_Chip-Seq_Bcells_Human1.38663361
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34373081
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.31862519
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31422653
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31176514
42TAF2_19829295_ChIP-Seq_ESCs_Human1.29190790
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.24162197
44TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.22748835
45PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.19269989
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17563216
47SA1_27219007_Chip-Seq_Bcells_Human1.17122920
48VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.17054646
49GATA3_26560356_Chip-Seq_TH1_Human1.15583338
50SPI1_23127762_ChIP-Seq_K562_Human1.15157239
51GATA1_22025678_ChIP-Seq_K562_Human1.14957247
52P300_27268052_Chip-Seq_Bcells_Human1.14922255
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14051219
54PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.08000656
55PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.05785519
56RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05759316
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.05252440
58NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03434551
59RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03351067
60CTCF_20526341_ChIP-Seq_ESCs_Human1.03030501
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01311643
62CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99257992
63BCOR_27268052_Chip-Seq_Bcells_Human0.97619865
64* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97185238
65IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96967955
66* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.96205677
67FLI1_27457419_Chip-Seq_LIVER_Mouse0.95209196
68GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94313658
69* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93174940
70SCL_19346495_ChIP-Seq_HPC-7_Human0.93005107
71BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92205871
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.92125863
73HTT_18923047_ChIP-ChIP_STHdh_Human0.91508829
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90917701
75VDR_24763502_ChIP-Seq_THP-1_Human0.90349985
76CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87935286
77FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86825296
78NANOG_20526341_ChIP-Seq_ESCs_Human0.86237441
79OCT4_20526341_ChIP-Seq_ESCs_Human0.84496942
80ELF1_20517297_ChIP-Seq_JURKAT_Human0.83044206
81GATA6_21074721_ChIP-Seq_CACO-2_Human0.82734207
82CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82047697
83EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.81629773
84BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.81220351
85PCGF2_27294783_Chip-Seq_ESCs_Mouse0.80703961
86SPI1_20517297_ChIP-Seq_HL60_Human0.80507635
87* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79634040
88YY1_22570637_ChIP-Seq_MALME-3M_Human0.79034916
89E2F1_20622854_ChIP-Seq_HELA_Human0.78718335
90FOXA1_25329375_ChIP-Seq_VCAP_Human0.78699773
91FOXA1_27270436_Chip-Seq_PROSTATE_Human0.78699773
92EGR1_19032775_ChIP-ChIP_M12_Human0.78613503
93FOXH1_21741376_ChIP-Seq_ESCs_Human0.78454169
94PCGF2_27294783_Chip-Seq_NPCs_Mouse0.76871924
95SRY_22984422_ChIP-ChIP_TESTIS_Rat0.76752814
96FOXH1_21741376_ChIP-Seq_EPCs_Human0.75828214
97GATA1_19941827_ChIP-Seq_MEL_Mouse0.74656165
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.72916996
99EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.72399376
100P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.71885888

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.85433129
2MP0006082_CNS_inflammation5.31967693
3MP0003763_abnormal_thymus_physiology4.02865976
4MP0001835_abnormal_antigen_presentation3.56597442
5MP0009785_altered_susceptibility_to3.45672231
6MP0001873_stomach_inflammation3.36263892
7MP0005000_abnormal_immune_tolerance3.26383610
8MP0009333_abnormal_splenocyte_physiolog3.19008194
9MP0001800_abnormal_humoral_immune3.10311916
10MP0005025_abnormal_response_to3.00462050
11MP0002723_abnormal_immune_serum2.83481360
12MP0002420_abnormal_adaptive_immunity2.78851338
13MP0001819_abnormal_immune_cell2.70291360
14MP0003436_decreased_susceptibility_to2.63110988
15MP0002148_abnormal_hypersensitivity_rea2.57711961
16MP0001790_abnormal_immune_system2.37505315
17MP0005387_immune_system_phenotype2.37505315
18MP0002452_abnormal_antigen_presenting2.36810662
19MP0002419_abnormal_innate_immunity2.29032278
20MP0003866_abnormal_defecation2.15189513
21MP0000685_abnormal_immune_system2.14866489
22MP0000716_abnormal_immune_system2.10504506
23MP0002398_abnormal_bone_marrow2.10274265
24MP0010155_abnormal_intestine_physiology2.08343150
25MP0000703_abnormal_thymus_morphology2.03361547
26MP0002405_respiratory_system_inflammati2.02829030
27MP0003724_increased_susceptibility_to2.02766154
28MP0003448_altered_tumor_morphology1.97033617
29MP0002933_joint_inflammation1.90775852
30MP0004947_skin_inflammation1.83787921
31MP0002722_abnormal_immune_system1.82233195
32MP0000689_abnormal_spleen_morphology1.75661647
33MP0001845_abnormal_inflammatory_respons1.75535608
34MP0003045_fibrosis1.74290762
35MP0000858_altered_metastatic_potential1.66508524
36MP0002429_abnormal_blood_cell1.56819059
37MP0008469_abnormal_protein_level1.51548648
38MP0003011_delayed_dark_adaptation1.48589367
39MP0001851_eye_inflammation1.46633107
40MP0005464_abnormal_platelet_physiology1.35211413
41MP0002166_altered_tumor_susceptibility1.32682882
42MP0009763_increased_sensitivity_to1.29309622
43MP0004782_abnormal_surfactant_physiolog1.27109216
44MP0002877_abnormal_melanocyte_morpholog1.18761050
45MP0005166_decreased_susceptibility_to1.17447512
46MP0010307_abnormal_tumor_latency1.17341801
47MP0001533_abnormal_skeleton_physiology1.12597811
48MP0002006_tumorigenesis1.10969449
49MP0008873_increased_physiological_sensi1.08920920
50MP0001986_abnormal_taste_sensitivity1.08728321
51MP0001853_heart_inflammation1.06862512
52MP0003690_abnormal_glial_cell1.04182045
53MP0003183_abnormal_peptide_metabolism1.02876938
54MP0004145_abnormal_muscle_electrophysio1.02765276
55MP0009764_decreased_sensitivity_to1.01849134
56MP0002277_abnormal_respiratory_mucosa1.01739242
57MP0009765_abnormal_xenobiotic_induced0.96798540
58MP0002998_abnormal_bone_remodeling0.95874029
59MP0005310_abnormal_salivary_gland0.93220545
60MP0004130_abnormal_muscle_cell0.88938905
61MP0004381_abnormal_hair_follicle0.88649432
62MP0000920_abnormal_myelination0.88137561
63MP0002234_abnormal_pharynx_morphology0.79880893
64MP0002693_abnormal_pancreas_physiology0.79136829
65MP0005075_abnormal_melanosome_morpholog0.78934932
66MP0003075_altered_response_to0.78868005
67MP0002019_abnormal_tumor_incidence0.78338668
68MP0003786_premature_aging0.76346652
69MP0002653_abnormal_ependyma_morphology0.76114693
70MP0000465_gastrointestinal_hemorrhage0.76038842
71MP0001919_abnormal_reproductive_system0.75399399
72MP0002132_abnormal_respiratory_system0.74167785
73MP0003300_gastrointestinal_ulcer0.72886817
74MP0004510_myositis0.70634871
75MP0001905_abnormal_dopamine_level0.69287634
76MP0003137_abnormal_impulse_conducting0.64967245
77MP0004883_abnormal_blood_vessel0.64602276
78MP0005623_abnormal_meninges_morphology0.63691860
79MP0003195_calcinosis0.63546520
80MP0001663_abnormal_digestive_system0.62973611
81MP0002876_abnormal_thyroid_physiology0.62620101
82MP0004142_abnormal_muscle_tone0.59112851
83MP0001188_hyperpigmentation0.54957954
84MP0001765_abnormal_ion_homeostasis0.52692672
85MP0002163_abnormal_gland_morphology0.50637004
86MP0008875_abnormal_xenobiotic_pharmacok0.49194908
87MP0000343_altered_response_to0.48139967
88MP0003795_abnormal_bone_structure0.47817213
89MP0005377_hearing/vestibular/ear_phenot0.47779725
90MP0003878_abnormal_ear_physiology0.47779725
91MP0000490_abnormal_crypts_of0.47136274
92MP0001727_abnormal_embryo_implantation0.46877637
93MP0005390_skeleton_phenotype0.46264656
94MP0002332_abnormal_exercise_endurance0.45864133
95MP0002168_other_aberrant_phenotype0.44914311
96MP0005381_digestive/alimentary_phenotyp0.43874798
97MP0003303_peritoneal_inflammation0.42491485
98MP0003646_muscle_fatigue0.42337368
99MP0005389_reproductive_system_phenotype0.40820052
100MP0000604_amyloidosis0.40027080

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of T cell number (HP:0011839)8.21109041
2T lymphocytopenia (HP:0005403)7.52036193
3Abnormal delayed hypersensitivity skin test (HP:0002963)6.07244694
4Increased IgM level (HP:0003496)6.04177283
5Autoimmune hemolytic anemia (HP:0001890)5.72255983
6Abnormality of eosinophils (HP:0001879)5.46453793
7Abnormality of T cells (HP:0002843)5.46172932
8Autoimmune thrombocytopenia (HP:0001973)4.93175196
9Eosinophilia (HP:0001880)4.93108068
10Hypoproteinemia (HP:0003075)4.78186515
11IgG deficiency (HP:0004315)4.72009499
12Abnormality of macrophages (HP:0004311)4.49003061
13Aplastic anemia (HP:0001915)4.36362874
14Granulocytopenia (HP:0001913)4.33455166
15Leukocytosis (HP:0001974)4.29179953
16Hemiplegia (HP:0002301)4.13884894
17Encephalitis (HP:0002383)4.13414743
18Severe combined immunodeficiency (HP:0004430)4.09445750
19Elevated erythrocyte sedimentation rate (HP:0003565)4.08305311
20Meningitis (HP:0001287)3.86923395
21Stomatitis (HP:0010280)3.85741495
22Recurrent abscess formation (HP:0002722)3.82088308
23Abnormality of T cell physiology (HP:0011840)3.81089108
24Chronic diarrhea (HP:0002028)3.45147010
25Recurrent cutaneous fungal infections (HP:0011370)3.44359221
26Chronic mucocutaneous candidiasis (HP:0002728)3.44359221
27Recurrent gram-negative bacterial infections (HP:0005420)3.37509928
28Myositis (HP:0100614)3.33699575
29Combined immunodeficiency (HP:0005387)3.32693082
30Hypochromic anemia (HP:0001931)3.29466806
31Recurrent bronchitis (HP:0002837)3.27927050
32Recurrent fungal infections (HP:0002841)3.23853141
33Retrobulbar optic neuritis (HP:0100654)3.22199936
34Optic neuritis (HP:0100653)3.22199936
35Vasculitis (HP:0002633)3.14207973
36Hypoalbuminemia (HP:0003073)3.08962464
37Abnormal albumin level (HP:0012116)3.08962464
38Agammaglobulinemia (HP:0004432)3.08880284
39Eczematoid dermatitis (HP:0000976)3.08852586
40Hypergammaglobulinemia (HP:0010702)3.04646916
41Gastrointestinal infarctions (HP:0005244)3.00860271
42Abnormality of cells of the lymphoid lineage (HP:0012140)2.96592238
43Orchitis (HP:0100796)2.92091014
44Joint swelling (HP:0001386)2.92049323
45Chronic obstructive pulmonary disease (HP:0006510)2.90926972
46Obstructive lung disease (HP:0006536)2.90926972
47Recurrent viral infections (HP:0004429)2.88159829
48Pustule (HP:0200039)2.84573743
49Recurrent bacterial skin infections (HP:0005406)2.76521595
50Pulmonary infiltrates (HP:0002113)2.70318177
51Thyroiditis (HP:0100646)2.68365935
52Recurrent skin infections (HP:0001581)2.64529110
53Increased serum ferritin (HP:0003281)2.57812995
54Hypoplasia of the thymus (HP:0000778)2.54575505
55Gangrene (HP:0100758)2.43800506
56Lymphopenia (HP:0001888)2.43743568
57Hemoptysis (HP:0002105)2.43538931
58Abnormality of the prostate (HP:0008775)2.43038084
59Alveolar cell carcinoma (HP:0006519)2.42190423
60Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.41034134
61Decreased activity of mitochondrial respiratory chain (HP:0008972)2.41034134
62Decreased electroretinogram (ERG) amplitude (HP:0000654)2.35480917
63Panhypogammaglobulinemia (HP:0003139)2.34589605
64Chest pain (HP:0100749)2.30104285
65Pulmonary embolism (HP:0002204)2.29943137
66Lymphoma (HP:0002665)2.28602234
67Mediastinal lymphadenopathy (HP:0100721)2.26397142
68Anorexia (HP:0002039)2.24593168
69IgM deficiency (HP:0002850)2.19280525
70Bronchitis (HP:0012387)2.16349134
71Ureteral stenosis (HP:0000071)2.16012254
72Keratoconjunctivitis (HP:0001096)2.15728324
73Urticaria (HP:0001025)2.15691160
74Keratoconjunctivitis sicca (HP:0001097)2.13872810
75Abnormality of iron homeostasis (HP:0011031)2.13269399
76Tetraplegia (HP:0002445)2.05908342
77Nasal polyposis (HP:0100582)2.03422105
78Neoplasm of the tracheobronchial system (HP:0100552)2.03055696
79Periodontitis (HP:0000704)2.02796475
80Ureteral obstruction (HP:0006000)2.01520811
81Gingivitis (HP:0000230)1.99629992
82Increased CSF protein (HP:0002922)1.99102373
83Basal ganglia calcification (HP:0002135)1.92559771
84Abnormality of the pleura (HP:0002103)1.90831091
85Recurrent otitis media (HP:0000403)1.89128904
86Skin rash (HP:0000988)1.88697337
87Abolished electroretinogram (ERG) (HP:0000550)1.85095435
88Abnormality of transition element cation homeostasis (HP:0011030)1.84818122
89Abnormality of the common coagulation pathway (HP:0010990)1.83545055
90Diplopia (HP:0000651)1.83223702
91Abnormality of binocular vision (HP:0011514)1.83223702
92Keratitis (HP:0000491)1.81918159
93Abnormality of liposaccharide metabolism (HP:0010968)1.76798090
94Abnormality of glycosphingolipid metabolism (HP:0004343)1.76798090
95Abnormality of glycolipid metabolism (HP:0010969)1.76798090
96Hyponatremia (HP:0002902)1.76168543
97Radial bowing (HP:0002986)1.74307917
98Abnormality of the nasal mucosa (HP:0000433)1.69784077
99Pulmonary fibrosis (HP:0002206)1.68080364
100Oral leukoplakia (HP:0002745)1.67869125

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK8.95859296
2MAP4K14.05821105
3KDR3.77252150
4TLK13.22966729
5ITK2.99484229
6PIK3CA2.83778667
7FES2.73287601
8CSK2.39375066
9TESK22.30557261
10GRK72.25030269
11LCK1.93219732
12ZAP701.84819123
13STK101.82061561
14BCKDK1.79526328
15RIPK41.72350087
16TNK21.71951215
17SYK1.70949904
18TAOK31.70018541
19GRK61.68388610
20BTK1.64022948
21JAK31.52769176
22TGFBR21.48527343
23PRKCQ1.45509579
24KIT1.40913679
25MARK31.36081229
26PRKCH1.30037892
27IRAK41.29875894
28IKBKB1.25270315
29TYRO31.22067990
30IKBKE1.16132979
31ADRBK21.15845084
32BMPR21.14410121
33LYN1.14239647
34JAK11.05693395
35MAP3K111.01654872
36TEC1.00305400
37HCK0.94611614
38TBK10.93570224
39PIK3CG0.88874546
40FYN0.86117527
41PIM10.85057689
42CSF1R0.82824460
43TYK20.82729876
44BLK0.81174243
45JAK20.80662878
46MAP2K60.79338357
47CAMKK20.75474674
48MOS0.73148574
49RET0.73064891
50WNK40.72132524
51FGFR10.70593242
52TESK10.68239990
53PDK10.66487766
54GRK50.61844420
55INSR0.61407618
56IGF1R0.61252805
57MAPK120.60177192
58EPHB10.56757928
59PDGFRB0.55288250
60MAP3K140.55022193
61DAPK20.52491187
62MATK0.51546726
63FGR0.49022150
64GRK10.44312369
65LIMK10.43749920
66DAPK10.42280654
67MUSK0.41591889
68ADRBK10.41574000
69MAPKAPK30.41271624
70STK110.41162460
71EPHA30.39683188
72MAP2K70.38089419
73PTK2B0.34066882
74PRKCD0.33736227
75OXSR10.33430576
76MST40.32130811
77NEK60.31015410
78PRKD20.29439107
79MAPKAPK20.28327925
80MAPK110.27457596
81SRC0.27350440
82MAP2K30.26967903
83BUB10.26253737
84INSRR0.26074730
85PRKCA0.25950892
86PRKACA0.25223205
87OBSCN0.24181060
88PRKD10.23866682
89CAMK2A0.23418861
90MAP3K60.22398476
91MAP4K20.20802443
92FRK0.19605824
93ABL10.19520494
94TIE10.18087615
95MAP2K20.17847131
96AURKA0.14635076
97RPS6KA50.14475908
98CAMKK10.14248260
99CDK190.12125177
100MAPK30.11583886

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.12213614
2Graft-versus-host disease_Homo sapiens_hsa053324.99812946
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046504.56240426
4Autoimmune thyroid disease_Homo sapiens_hsa053204.10542056
5Allograft rejection_Homo sapiens_hsa053303.93558752
6Antigen processing and presentation_Homo sapiens_hsa046123.49711582
7Type I diabetes mellitus_Homo sapiens_hsa049403.17225224
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.65545801
9T cell receptor signaling pathway_Homo sapiens_hsa046602.53847749
10Hematopoietic cell lineage_Homo sapiens_hsa046402.31287577
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.14868444
12Measles_Homo sapiens_hsa051622.10660316
13Viral myocarditis_Homo sapiens_hsa054161.96124254
14Rheumatoid arthritis_Homo sapiens_hsa053231.89840083
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.78738206
16Caffeine metabolism_Homo sapiens_hsa002321.76785003
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.74481814
18Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.70536570
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.66246299
20Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.61031681
21Malaria_Homo sapiens_hsa051441.54210134
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.54013950
23Staphylococcus aureus infection_Homo sapiens_hsa051501.51535891
24Leishmaniasis_Homo sapiens_hsa051401.46722964
25Linoleic acid metabolism_Homo sapiens_hsa005911.46649626
26Chemokine signaling pathway_Homo sapiens_hsa040621.32320612
27Osteoclast differentiation_Homo sapiens_hsa043801.29707451
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.29080703
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27503991
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.24912756
31Salmonella infection_Homo sapiens_hsa051321.15304134
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12355469
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12123384
34African trypanosomiasis_Homo sapiens_hsa051431.11018776
35Proteasome_Homo sapiens_hsa030501.07368484
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.01081011
37Intestinal immune network for IgA production_Homo sapiens_hsa046720.97450481
38Apoptosis_Homo sapiens_hsa042100.95772753
39Legionellosis_Homo sapiens_hsa051340.94917124
40Phototransduction_Homo sapiens_hsa047440.91352843
41RNA polymerase_Homo sapiens_hsa030200.89333847
42Herpes simplex infection_Homo sapiens_hsa051680.86977761
43B cell receptor signaling pathway_Homo sapiens_hsa046620.81948697
44TNF signaling pathway_Homo sapiens_hsa046680.80118711
45Nitrogen metabolism_Homo sapiens_hsa009100.75120726
46Ether lipid metabolism_Homo sapiens_hsa005650.74768120
47Shigellosis_Homo sapiens_hsa051310.72260462
48Influenza A_Homo sapiens_hsa051640.70432270
49Asthma_Homo sapiens_hsa053100.70142788
50Pertussis_Homo sapiens_hsa051330.66740605
51Tuberculosis_Homo sapiens_hsa051520.59166724
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56432597
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54446990
54Toxoplasmosis_Homo sapiens_hsa051450.52361779
55Prion diseases_Homo sapiens_hsa050200.50153770
56Epstein-Barr virus infection_Homo sapiens_hsa051690.47943894
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46267124
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40374524
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39698536
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.38776632
61VEGF signaling pathway_Homo sapiens_hsa043700.38503261
62HTLV-I infection_Homo sapiens_hsa051660.38358338
63Arachidonic acid metabolism_Homo sapiens_hsa005900.34455463
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34447151
65Platelet activation_Homo sapiens_hsa046110.30610974
66Non-small cell lung cancer_Homo sapiens_hsa052230.29864662
67Endocytosis_Homo sapiens_hsa041440.28097415
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.27603959
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27541324
70Phagosome_Homo sapiens_hsa041450.27001484
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.26818557
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25437604
73Ras signaling pathway_Homo sapiens_hsa040140.25002968
74Systemic lupus erythematosus_Homo sapiens_hsa053220.24946047
75Oxidative phosphorylation_Homo sapiens_hsa001900.22451044
76Vitamin digestion and absorption_Homo sapiens_hsa049770.19797937
77Hepatitis B_Homo sapiens_hsa051610.17538599
78Regulation of autophagy_Homo sapiens_hsa041400.15444973
79Acute myeloid leukemia_Homo sapiens_hsa052210.14777203
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.12972909
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.11493518
82Hepatitis C_Homo sapiens_hsa051600.10889309
83Retinol metabolism_Homo sapiens_hsa008300.10768637
84Olfactory transduction_Homo sapiens_hsa047400.10243080
85Lysosome_Homo sapiens_hsa041420.09900171
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.08373261
87Parkinsons disease_Homo sapiens_hsa050120.08305758
88Glycerolipid metabolism_Homo sapiens_hsa005610.08286062
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.07714298
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.07380758
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.07367696
92MAPK signaling pathway_Homo sapiens_hsa040100.07326298
93Fat digestion and absorption_Homo sapiens_hsa049750.06918117
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.06749758
95Complement and coagulation cascades_Homo sapiens_hsa046100.04573236
96Folate biosynthesis_Homo sapiens_hsa007900.04448851
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.04369806
98Chemical carcinogenesis_Homo sapiens_hsa052040.03056891
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.02923333
100Sulfur metabolism_Homo sapiens_hsa00920-0.0075914

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