GNL3L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.93346328
2nuclear pore organization (GO:0006999)6.32504148
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.91848381
4synaptic vesicle exocytosis (GO:0016079)5.58903007
5pore complex assembly (GO:0046931)5.36950294
6synaptic vesicle maturation (GO:0016188)5.32411277
7vocalization behavior (GO:0071625)5.30355465
8regulation of synaptic vesicle exocytosis (GO:2000300)5.15023546
9neuron cell-cell adhesion (GO:0007158)5.09734337
10glutamate secretion (GO:0014047)5.04452187
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.76640229
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.72046792
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.71904989
14protein localization to synapse (GO:0035418)4.64605736
15neurotransmitter secretion (GO:0007269)4.54735107
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.48965974
17regulation of glutamate receptor signaling pathway (GO:1900449)4.47636307
18regulation of synaptic vesicle transport (GO:1902803)4.47263825
19synaptic vesicle docking involved in exocytosis (GO:0016081)4.47132572
20locomotory exploration behavior (GO:0035641)4.45666281
21DNA strand elongation involved in DNA replication (GO:0006271)4.22120794
22neuronal action potential propagation (GO:0019227)4.20199140
23DNA unwinding involved in DNA replication (GO:0006268)4.17745267
24mitotic sister chromatid cohesion (GO:0007064)4.16476395
25DNA strand elongation (GO:0022616)4.08269809
26mitotic nuclear envelope disassembly (GO:0007077)4.02480868
27presynaptic membrane assembly (GO:0097105)4.00075098
28exploration behavior (GO:0035640)3.99992445
29neuron-neuron synaptic transmission (GO:0007270)3.96968915
30double-strand break repair via nonhomologous end joining (GO:0006303)3.93593550
31non-recombinational repair (GO:0000726)3.93593550
32neurotransmitter-gated ion channel clustering (GO:0072578)3.91522058
33negative regulation of synaptic transmission, GABAergic (GO:0032229)3.87749713
34presynaptic membrane organization (GO:0097090)3.87074300
35proline transport (GO:0015824)3.86839114
36ionotropic glutamate receptor signaling pathway (GO:0035235)3.85203546
37synaptic transmission, glutamatergic (GO:0035249)3.83246289
38postsynaptic membrane organization (GO:0001941)3.82119346
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.79149447
40regulation of neuronal synaptic plasticity (GO:0048168)3.78783302
41neurotransmitter transport (GO:0006836)3.78599269
42gamma-aminobutyric acid signaling pathway (GO:0007214)3.78251173
43positive regulation of synapse maturation (GO:0090129)3.76735346
44folic acid-containing compound biosynthetic process (GO:0009396)3.75557429
45nuclear envelope disassembly (GO:0051081)3.71148691
46membrane disassembly (GO:0030397)3.71148691
47ribosome assembly (GO:0042255)3.70631154
48regulation of long-term neuronal synaptic plasticity (GO:0048169)3.69946675
49DNA duplex unwinding (GO:0032508)3.65015963
50spliceosomal tri-snRNP complex assembly (GO:0000244)3.64869562
51negative regulation of dendrite morphogenesis (GO:0050774)3.64617932
52telomere maintenance via semi-conservative replication (GO:0032201)3.62704972
53glutamate receptor signaling pathway (GO:0007215)3.62661492
54mitotic chromosome condensation (GO:0007076)3.62432691
55regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.61955068
56DNA geometric change (GO:0032392)3.60409604
57positive regulation of synaptic transmission, GABAergic (GO:0032230)3.59368249
58synaptic vesicle endocytosis (GO:0048488)3.57939579
59DNA replication initiation (GO:0006270)3.57851827
60IMP biosynthetic process (GO:0006188)3.55912362
61layer formation in cerebral cortex (GO:0021819)3.55752619
62maturation of 5.8S rRNA (GO:0000460)3.55177531
63gamma-aminobutyric acid transport (GO:0015812)3.55167105
64neuron recognition (GO:0008038)3.53514916
65regulation of translational fidelity (GO:0006450)3.53008383
66cell migration in hindbrain (GO:0021535)3.50575863
67regulation of synapse structural plasticity (GO:0051823)3.50100259
68transmission of nerve impulse (GO:0019226)3.45424372
69mitotic sister chromatid segregation (GO:0000070)3.41619045
70long-term synaptic potentiation (GO:0060291)3.40772382
71viral mRNA export from host cell nucleus (GO:0046784)3.40769203
72regulation of neurotransmitter secretion (GO:0046928)3.40746359
73cerebellar Purkinje cell differentiation (GO:0021702)3.37914966
74DNA replication-dependent nucleosome organization (GO:0034723)3.37667811
75DNA replication-dependent nucleosome assembly (GO:0006335)3.37667811
76telomere maintenance via recombination (GO:0000722)3.37058050
77regulation of neurotransmitter levels (GO:0001505)3.36964661
78long-term memory (GO:0007616)3.36671319
79regulation of excitatory postsynaptic membrane potential (GO:0060079)3.36288498
80regulation of centriole replication (GO:0046599)3.33617971
81negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.31264588
82synapse assembly (GO:0007416)3.30162273
83regulation of postsynaptic membrane potential (GO:0060078)3.28003715
84mitotic metaphase plate congression (GO:0007080)3.27806371
85positive regulation of membrane potential (GO:0045838)3.27421186
86startle response (GO:0001964)3.27394700
87innervation (GO:0060384)3.26896878
88DNA replication checkpoint (GO:0000076)3.24783156
89regulation of synaptic transmission, glutamatergic (GO:0051966)3.23679114
90neuromuscular process controlling posture (GO:0050884)3.23359210
91negative regulation of dendrite development (GO:2000171)3.22586358
92protein localization to chromosome, centromeric region (GO:0071459)3.22091400
93regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.21177870
94chromatin assembly (GO:0031497)3.21037541
95sister chromatid segregation (GO:0000819)3.20788722
96regulation of synaptic transmission, GABAergic (GO:0032228)3.20620785
97regulation of neurotransmitter transport (GO:0051588)3.19405731
98response to histamine (GO:0034776)3.18523260
99positive regulation of synapse assembly (GO:0051965)3.18370296
100IMP metabolic process (GO:0046040)3.16442379
101mitotic recombination (GO:0006312)3.15278592
102axonal fasciculation (GO:0007413)3.15032078
103regulation of synapse maturation (GO:0090128)3.14600639
104activation of protein kinase A activity (GO:0034199)3.14416986
105striatum development (GO:0021756)3.14216373
106regulation of vesicle fusion (GO:0031338)3.14014997
107mitochondrial RNA metabolic process (GO:0000959)3.13281719
108nucleobase biosynthetic process (GO:0046112)3.11708535
109positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.11045695
110regulation of synaptic plasticity (GO:0048167)3.10903021
111* ribosome biogenesis (GO:0042254)3.10459880
112tRNA aminoacylation for protein translation (GO:0006418)3.09929247
113formation of translation preinitiation complex (GO:0001731)3.07241937
114regulation of centrosome cycle (GO:0046605)3.06950795
115tRNA aminoacylation (GO:0043039)3.06785198
116amino acid activation (GO:0043038)3.06785198
117folic acid metabolic process (GO:0046655)3.06750016
118pre-miRNA processing (GO:0031054)3.06714351
119G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.06605198
120dendritic spine morphogenesis (GO:0060997)3.06539420
121DNA conformation change (GO:0071103)3.05768048
122membrane depolarization during action potential (GO:0086010)3.05215555
123synaptic transmission (GO:0007268)3.03933045
124auditory behavior (GO:0031223)3.03560378
125establishment of synaptic vesicle localization (GO:0097480)3.03425289
126synaptic vesicle transport (GO:0048489)3.03425289
127DNA topological change (GO:0006265)3.02650995
128cellular potassium ion homeostasis (GO:0030007)3.02387779
129chromatin assembly or disassembly (GO:0006333)3.00683986
130membrane hyperpolarization (GO:0060081)3.00491717
131vesicle transport along microtubule (GO:0047496)3.00462299
132regulation of centrosome duplication (GO:0010824)3.00438973
133response to auditory stimulus (GO:0010996)3.00272226
134regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.99766576
135somatic hypermutation of immunoglobulin genes (GO:0016446)2.98316168
136somatic diversification of immune receptors via somatic mutation (GO:0002566)2.98316168
137behavioral defense response (GO:0002209)2.98273730
138behavioral fear response (GO:0001662)2.98273730
139cerebellar granule cell differentiation (GO:0021707)2.98116006
140regulation of RNA export from nucleus (GO:0046831)2.96917123
141mechanosensory behavior (GO:0007638)2.95702078
142positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.94953569
143learning (GO:0007612)2.94495505
144regulation of translational termination (GO:0006449)2.93806894
145membrane depolarization (GO:0051899)2.93173758
146metaphase plate congression (GO:0051310)2.92863730
147nuclear envelope organization (GO:0006998)2.91829891
148positive regulation of neurotransmitter transport (GO:0051590)2.90620863
149organelle transport along microtubule (GO:0072384)2.90241948
150regulation of spindle checkpoint (GO:0090231)2.89253765
151neuromuscular synaptic transmission (GO:0007274)2.89131619
152transferrin transport (GO:0033572)2.88368150
153protein localization to kinetochore (GO:0034501)2.88000015
154establishment of vesicle localization (GO:0051650)2.87264136
155purine nucleobase biosynthetic process (GO:0009113)2.86902127
156positive regulation of synaptic transmission (GO:0050806)2.86792970
157meiotic chromosome segregation (GO:0045132)2.86438962
158dendrite development (GO:0016358)2.86398629
159rRNA processing (GO:0006364)2.86363357
160tRNA methylation (GO:0030488)2.85817593
161establishment of integrated proviral latency (GO:0075713)2.84555815
162regulation of histone H3-K9 methylation (GO:0051570)2.83965107
163regulation of synaptic transmission (GO:0050804)2.82856667
164positive regulation of chromosome segregation (GO:0051984)2.82304290
165intraspecies interaction between organisms (GO:0051703)2.81783782
166DNA strand renaturation (GO:0000733)2.81175486
167pseudouridine synthesis (GO:0001522)2.78589648
168negative regulation of DNA repair (GO:0045738)2.77868510
169rRNA metabolic process (GO:0016072)2.77406278
170telomere organization (GO:0032200)2.76751169
171replication fork processing (GO:0031297)2.75330338
172telomere maintenance (GO:0000723)2.75178387
173peptidyl-arginine omega-N-methylation (GO:0035247)2.73614203
174DNA synthesis involved in DNA repair (GO:0000731)2.72998924
175spliceosomal snRNP assembly (GO:0000387)2.72959175
176protein export from nucleus (GO:0006611)2.72391301
177histone arginine methylation (GO:0034969)2.70921568
178negative regulation of chromosome segregation (GO:0051985)2.70902736
179CENP-A containing nucleosome assembly (GO:0034080)2.70267677
180hepatocyte apoptotic process (GO:0097284)2.70138988
181nucleotide-excision repair, DNA gap filling (GO:0006297)2.69227336
182spindle checkpoint (GO:0031577)2.68506790
183rRNA transcription (GO:0009303)2.66299093
184establishment of chromosome localization (GO:0051303)2.65921104
185regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.65553524
186chromatin remodeling at centromere (GO:0031055)2.64482931
187positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.63325522
188somatic recombination of immunoglobulin gene segments (GO:0016447)2.61022625
189regulation of sister chromatid cohesion (GO:0007063)2.60493229
190maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.60030131
191snRNA metabolic process (GO:0016073)2.59721125
192mitotic spindle checkpoint (GO:0071174)2.59533160
193regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.59239436
194regulation of mitotic metaphase/anaphase transition (GO:0030071)2.59239436
195somatic cell DNA recombination (GO:0016444)2.58931228
196somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.58931228
197telomere maintenance via telomere lengthening (GO:0010833)2.58369932
198regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.58347739
199regulation of chromosome segregation (GO:0051983)2.57808653
200regulation of histone H3-K4 methylation (GO:0051569)2.57222281

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.82142309
2EZH2_22144423_ChIP-Seq_EOC_Human5.63339153
3GBX2_23144817_ChIP-Seq_PC3_Human4.24960367
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.01877757
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.98597171
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.33740420
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.32887997
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.10438450
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.07782636
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.91498665
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.90591864
12REST_21632747_ChIP-Seq_MESCs_Mouse2.80372755
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.79406506
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.76269721
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.70700580
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.68844091
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.65986714
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.60303607
19TAF15_26573619_Chip-Seq_HEK293_Human2.56066589
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53506935
21* EST1_17652178_ChIP-ChIP_JURKAT_Human2.43467153
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.39969815
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.36864669
24GABP_17652178_ChIP-ChIP_JURKAT_Human2.33693126
25ETS1_20019798_ChIP-Seq_JURKAT_Human2.33642997
26E2F1_21310950_ChIP-Seq_MCF-7_Human2.32465529
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.32264492
28REST_18959480_ChIP-ChIP_MESCs_Mouse2.31650253
29JARID2_20075857_ChIP-Seq_MESCs_Mouse2.31640858
30* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28592790
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.28465452
32EZH2_18974828_ChIP-Seq_MESCs_Mouse2.28138352
33RNF2_18974828_ChIP-Seq_MESCs_Mouse2.28138352
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24002311
35* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.22940711
36CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19842327
37RARB_27405468_Chip-Seq_BRAIN_Mouse2.19294819
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.15080428
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14088415
40SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13199762
41* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.10460648
42EED_16625203_ChIP-ChIP_MESCs_Mouse2.10179221
43NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09796300
44MYC_22102868_ChIP-Seq_BL_Human2.09039825
45CREB1_15753290_ChIP-ChIP_HEK293T_Human2.06890610
46VDR_23849224_ChIP-Seq_CD4+_Human2.06308776
47FOXP3_21729870_ChIP-Seq_TREG_Human2.06034056
48MTF2_20144788_ChIP-Seq_MESCs_Mouse2.04205595
49CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02666235
50THAP11_20581084_ChIP-Seq_MESCs_Mouse2.00638915
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98272327
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.96694008
53* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.96341777
54* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.93425527
55RNF2_27304074_Chip-Seq_ESCs_Mouse1.92379191
56SMAD4_21799915_ChIP-Seq_A2780_Human1.92278113
57* ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91102747
58* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89975079
59IGF1R_20145208_ChIP-Seq_DFB_Human1.89586848
60EZH2_27294783_Chip-Seq_ESCs_Mouse1.88865872
61DROSHA_22980978_ChIP-Seq_HELA_Human1.88069145
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.87412360
63ELK1_19687146_ChIP-ChIP_HELA_Human1.86885662
64DCP1A_22483619_ChIP-Seq_HELA_Human1.86355565
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.85024708
66SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84394706
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84141822
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83508059
69* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80892057
70XRN2_22483619_ChIP-Seq_HELA_Human1.80289723
71KDM5A_27292631_Chip-Seq_BREAST_Human1.79779729
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78821645
73P300_19829295_ChIP-Seq_ESCs_Human1.77226838
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74837299
75GABP_19822575_ChIP-Seq_HepG2_Human1.74729259
76CIITA_25753668_ChIP-Seq_RAJI_Human1.71376929
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70781413
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70299741
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.69022044
80AR_21572438_ChIP-Seq_LNCaP_Human1.66837113
81ERG_20887958_ChIP-Seq_HPC-7_Mouse1.66629370
82RNF2_27304074_Chip-Seq_NSC_Mouse1.64410533
83POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61881712
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61451029
85SRF_21415370_ChIP-Seq_HL-1_Mouse1.61221506
86AR_21909140_ChIP-Seq_LNCAP_Human1.59444501
87E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59154228
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58110661
89SMAD_19615063_ChIP-ChIP_OVARY_Human1.54162435
90ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51958369
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51653556
92FUS_26573619_Chip-Seq_HEK293_Human1.51084102
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.48766801
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48708521
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48506972
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.48481358
97SMAD3_21741376_ChIP-Seq_EPCs_Human1.48183733
98TFEB_21752829_ChIP-Seq_HELA_Human1.48148178
99ZNF274_21170338_ChIP-Seq_K562_Hela1.47245064
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44699853
101CBX2_27304074_Chip-Seq_ESCs_Mouse1.42171188
102EGR1_19374776_ChIP-ChIP_THP-1_Human1.41680585
103SOX2_21211035_ChIP-Seq_LN229_Gbm1.41410470
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41215805
105MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.40985367
106SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40500270
107MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40369105
108TTF2_22483619_ChIP-Seq_HELA_Human1.40024105
109IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39606530
110* STAT3_23295773_ChIP-Seq_U87_Human1.38989862
111E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.38665754
112HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37154720
113AR_25329375_ChIP-Seq_VCAP_Human1.34656465
114PIAS1_25552417_ChIP-Seq_VCAP_Human1.34409839
115SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34225107
116NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31394017
117GATA1_22025678_ChIP-Seq_K562_Human1.31188606
118ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29058995
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.28237611
120RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26317612
121RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26215389
122TCF4_23295773_ChIP-Seq_U87_Human1.26204991
123EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24980080
124YY1_21170310_ChIP-Seq_MESCs_Mouse1.24933879
125PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24304013
126* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24191153
127CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23855063
128* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23745659
129FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23576528
130STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22981186
131* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20907927
132CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18870720
133P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18530398
134HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18461904
135AR_19668381_ChIP-Seq_PC3_Human1.17077181
136JUN_21703547_ChIP-Seq_K562_Human1.16328017
137RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16190531
138AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15673734
139TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15395731
140* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14144082
141RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13699246
142CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13340462
143ARNT_22903824_ChIP-Seq_MCF-7_Human1.12106745
144BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11755930
145VDR_22108803_ChIP-Seq_LS180_Human1.11027274
146ER_23166858_ChIP-Seq_MCF-7_Human1.10425143
147UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09991770
148BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09947309
149RUNX2_22187159_ChIP-Seq_PCA_Human1.09682589
150MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08382950
151GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08357302
152CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07038459
153CHD1_26751641_Chip-Seq_LNCaP_Human1.06696497
154AHR_22903824_ChIP-Seq_MCF-7_Human1.06215061
155RING1B_27294783_Chip-Seq_ESCs_Mouse1.05870653
156SPI1_23547873_ChIP-Seq_NB4_Human1.05537326
157MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04883328
158PRDM14_20953172_ChIP-Seq_ESCs_Human1.04267969
159PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03862513
160SOX9_26525672_Chip-Seq_HEART_Mouse1.03190644
161ERG_21242973_ChIP-ChIP_JURKAT_Human1.02348472
162SALL1_21062744_ChIP-ChIP_HESCs_Human1.02134178
163KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01652848
164TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01224496
165TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01128896
166EWS_26573619_Chip-Seq_HEK293_Human1.00813673
167TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00591638
168NANOG_18555785_Chip-Seq_ESCs_Mouse0.99610476
169ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99484354
170TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99094932
171RING1B_27294783_Chip-Seq_NPCs_Mouse0.97711396
172NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97574876
173CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97383769
174CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97116954
175SMAD3_21741376_ChIP-Seq_ESCs_Human0.96901377
176MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96184931
177MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95937544
178* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95487410
179NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93317940
180* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92859297
181* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92450311
182STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91118640
183TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90779531
184POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90779531
185FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90127942
186VDR_21846776_ChIP-Seq_THP-1_Human0.89992614
187MYB_26560356_Chip-Seq_TH1_Human0.89851296
188MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89284839
189NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.87649753
190MYB_21317192_ChIP-Seq_ERMYB_Mouse0.85766836
191ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82790057
192BRD4_27068464_Chip-Seq_AML-cells_Mouse0.82783654
193STAT4_19710469_ChIP-ChIP_TH1__Mouse0.81386499
194MYC_18940864_ChIP-ChIP_HL60_Human0.81344483
195MYB_26560356_Chip-Seq_TH2_Human0.81159410
196E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.81146389
197* CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.81133645
198* SOX17_20123909_ChIP-Seq_XEN_Mouse0.80897266
199PKCTHETA_26484144_Chip-Seq_BREAST_Human0.80225495

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.88307475
2MP0008057_abnormal_DNA_replication4.45136659
3MP0010094_abnormal_chromosome_stability4.43914124
4MP0003880_abnormal_central_pattern4.31813854
5MP0003111_abnormal_nucleus_morphology3.96615869
6MP0003693_abnormal_embryo_hatching3.68153095
7MP0003635_abnormal_synaptic_transmissio3.65347471
8MP0004957_abnormal_blastocyst_morpholog3.40771036
9MP0004270_analgesia3.39586692
10MP0003077_abnormal_cell_cycle3.33563780
11MP0008058_abnormal_DNA_repair3.31466373
12MP0009046_muscle_twitch3.22429557
13MP0009745_abnormal_behavioral_response3.14082958
14MP0001968_abnormal_touch/_nociception3.00760143
15MP0002063_abnormal_learning/memory/cond2.98123486
16MP0002064_seizures2.93966710
17MP0002734_abnormal_mechanical_nocicepti2.79577465
18MP0002735_abnormal_chemical_nociception2.78902574
19MP0005423_abnormal_somatic_nervous2.72996230
20MP0002572_abnormal_emotion/affect_behav2.61562621
21MP0002272_abnormal_nervous_system2.53677157
22MP0002396_abnormal_hematopoietic_system2.52129471
23MP0008007_abnormal_cellular_replicative2.51953069
24MP0002822_catalepsy2.45028900
25MP0002736_abnormal_nociception_after2.41484579
26MP0010352_gastrointestinal_tract_polyps2.38494688
27MP0008932_abnormal_embryonic_tissue2.35227451
28MP0001486_abnormal_startle_reflex2.32616797
29MP0006276_abnormal_autonomic_nervous2.27579273
30MP0003787_abnormal_imprinting2.21514283
31MP0003122_maternal_imprinting2.12234675
32MP0001730_embryonic_growth_arrest2.08084951
33MP0001661_extended_life_span2.07875202
34MP0009697_abnormal_copulation2.07076925
35MP0002067_abnormal_sensory_capabilities2.04220517
36MP0002733_abnormal_thermal_nociception2.03333608
37MP0002184_abnormal_innervation2.00544938
38MP0001501_abnormal_sleep_pattern2.00203643
39MP0001970_abnormal_pain_threshold1.97615141
40MP0003786_premature_aging1.97558857
41MP0001188_hyperpigmentation1.97411392
42MP0005646_abnormal_pituitary_gland1.97191886
43MP0001440_abnormal_grooming_behavior1.96291970
44MP0002009_preneoplasia1.96026088
45MP0001984_abnormal_olfaction1.94018717
46MP0002877_abnormal_melanocyte_morpholog1.92064223
47MP0006035_abnormal_mitochondrial_morpho1.81742771
48MP0000778_abnormal_nervous_system1.80947479
49MP0009780_abnormal_chondrocyte_physiolo1.80441356
50MP0002557_abnormal_social/conspecific_i1.78779424
51MP0004924_abnormal_behavior1.78694814
52MP0005386_behavior/neurological_phenoty1.78694814
53MP0005076_abnormal_cell_differentiation1.77176788
54MP0001529_abnormal_vocalization1.74338601
55MP0004811_abnormal_neuron_physiology1.74051765
56MP0003763_abnormal_thymus_physiology1.73786667
57MP0000350_abnormal_cell_proliferation1.73349099
58MP0008260_abnormal_autophagy1.70362258
59MP0004808_abnormal_hematopoietic_stem1.66302505
60MP0004142_abnormal_muscle_tone1.66001982
61MP0002166_altered_tumor_susceptibility1.64549389
62MP0008569_lethality_at_weaning1.61170647
63MP0005645_abnormal_hypothalamus_physiol1.60790943
64MP0003646_muscle_fatigue1.60402749
65MP0003984_embryonic_growth_retardation1.58790345
66MP0001672_abnormal_embryogenesis/_devel1.58052667
67MP0005380_embryogenesis_phenotype1.58052667
68MP0000955_abnormal_spinal_cord1.55776858
69MP0010307_abnormal_tumor_latency1.54555568
70MP0002088_abnormal_embryonic_growth/wei1.52820782
71MP0002080_prenatal_lethality1.52641412
72MP0000358_abnormal_cell_content/1.51618913
73MP0004858_abnormal_nervous_system1.48775666
74MP0001697_abnormal_embryo_size1.47380278
75MP0002909_abnormal_adrenal_gland1.47043710
76MP0002882_abnormal_neuron_morphology1.46137498
77MP0004185_abnormal_adipocyte_glucose1.44053868
78MP0003221_abnormal_cardiomyocyte_apopto1.43955465
79MP0001905_abnormal_dopamine_level1.43265076
80MP0003950_abnormal_plasma_membrane1.42689424
81MP0003879_abnormal_hair_cell1.41957556
82MP0000313_abnormal_cell_death1.40869905
83MP0002019_abnormal_tumor_incidence1.39730877
84MP0005451_abnormal_body_composition1.37019486
85MP0002086_abnormal_extraembryonic_tissu1.34938907
86MP0002066_abnormal_motor_capabilities/c1.34757196
87MP0005499_abnormal_olfactory_system1.33948253
88MP0005394_taste/olfaction_phenotype1.33948253
89MP0000703_abnormal_thymus_morphology1.32060943
90MP0002006_tumorigenesis1.30682139
91MP0001502_abnormal_circadian_rhythm1.28589058
92MP0003718_maternal_effect1.26793949
93MP0003121_genomic_imprinting1.25084293
94MP0003656_abnormal_erythrocyte_physiolo1.24497470
95MP0004885_abnormal_endolymph1.23257062
96MP0005551_abnormal_eye_electrophysiolog1.21235807
97MP0002398_abnormal_bone_marrow1.20786936
98MP0002084_abnormal_developmental_patter1.19612750
99MP0004197_abnormal_fetal_growth/weight/1.17826693
100MP0010386_abnormal_urinary_bladder1.17664474
101MP0006072_abnormal_retinal_apoptosis1.16441103
102MP0004084_abnormal_cardiac_muscle1.15327209
103MP0001835_abnormal_antigen_presentation1.14399842
104MP0000631_abnormal_neuroendocrine_gland1.13941952
105MP0002152_abnormal_brain_morphology1.12861075
106MP0003329_amyloid_beta_deposits1.12578216
107MP0005464_abnormal_platelet_physiology1.10077499
108MP0001986_abnormal_taste_sensitivity1.09871898
109MP0005083_abnormal_biliary_tract1.08263825
110MP0003806_abnormal_nucleotide_metabolis1.07854549
111MP0008877_abnormal_DNA_methylation1.07207193
112MP0009672_abnormal_birth_weight1.07111100
113MP0002722_abnormal_immune_system1.06916981
114MP0002085_abnormal_embryonic_tissue1.06459975
115MP0005384_cellular_phenotype1.06063533
116MP0002229_neurodegeneration1.05385351
117MP0003566_abnormal_cell_adhesion1.04200134
118MP0000015_abnormal_ear_pigmentation1.03902428
119MP0002876_abnormal_thyroid_physiology1.03542344
120MP0003633_abnormal_nervous_system1.02932817
121MP0000490_abnormal_crypts_of1.01697728
122MP0002751_abnormal_autonomic_nervous1.01256749
123MP0005621_abnormal_cell_physiology1.00509690
124MP0000689_abnormal_spleen_morphology1.00168933
125MP0001963_abnormal_hearing_physiology1.00023855
126MP0002752_abnormal_somatic_nervous0.97656019
127MP0001873_stomach_inflammation0.97102816
128MP0003631_nervous_system_phenotype0.95945310
129MP0003123_paternal_imprinting0.94368811
130MP0000383_abnormal_hair_follicle0.92962053
131MP0004036_abnormal_muscle_relaxation0.92000894
132MP0001853_heart_inflammation0.90465328
133MP0004742_abnormal_vestibular_system0.88293849
134MP0008872_abnormal_physiological_respon0.87850336
135MP0002069_abnormal_eating/drinking_beha0.87537493
136MP0002429_abnormal_blood_cell0.87222868
137MP0003283_abnormal_digestive_organ0.87016470
138MP0008789_abnormal_olfactory_epithelium0.86739574
139MP0005501_abnormal_skin_physiology0.84804669
140MP0000013_abnormal_adipose_tissue0.84768950
141MP0001177_atelectasis0.83845523
142MP0002638_abnormal_pupillary_reflex0.83338486
143MP0010678_abnormal_skin_adnexa0.82410189
144MP0001727_abnormal_embryo_implantation0.81797041
145MP0005310_abnormal_salivary_gland0.80885806
146MP0005266_abnormal_metabolism0.80101487
147MP0004145_abnormal_muscle_electrophysio0.79914899
148MP0004085_abnormal_heartbeat0.79800327
149MP0002837_dystrophic_cardiac_calcinosis0.79658146
150MP0004381_abnormal_hair_follicle0.79331896
151MP0001485_abnormal_pinna_reflex0.78758467
152MP0002653_abnormal_ependyma_morphology0.78236762
153MP0005075_abnormal_melanosome_morpholog0.77876477
154MP0002269_muscular_atrophy0.77588255
155MP0000749_muscle_degeneration0.76659819
156MP0009703_decreased_birth_body0.76234920
157MP0004233_abnormal_muscle_weight0.76194736
158MP0003632_abnormal_nervous_system0.75987069
159MP0005253_abnormal_eye_physiology0.75691774
160MP0001849_ear_inflammation0.75177748
161MP0010234_abnormal_vibrissa_follicle0.74860590
162MP0002332_abnormal_exercise_endurance0.74817831
163MP0006292_abnormal_olfactory_placode0.74682530
164MP0009333_abnormal_splenocyte_physiolog0.73941892
165MP0003634_abnormal_glial_cell0.72635928
166MP0009278_abnormal_bone_marrow0.71968180
167MP0003861_abnormal_nervous_system0.71442647
168MP0000751_myopathy0.69975220
169MP0000569_abnormal_digit_pigmentation0.69490391
170MP0010630_abnormal_cardiac_muscle0.69191772
171MP0002060_abnormal_skin_morphology0.69037168
172MP0000716_abnormal_immune_system0.67238973
173MP0001299_abnormal_eye_distance/0.67232407
174MP0000685_abnormal_immune_system0.66794102
175MP0000026_abnormal_inner_ear0.66113446
176MP0001664_abnormal_digestion0.66101201
177MP0003943_abnormal_hepatobiliary_system0.65992556
178MP0003828_pulmonary_edema0.65521008
179MP0004215_abnormal_myocardial_fiber0.65136676
180MP0001943_abnormal_respiration0.64407368
181MP0008995_early_reproductive_senescence0.64346008
182MP0005171_absent_coat_pigmentation0.64216566
183MP0000465_gastrointestinal_hemorrhage0.63585434
184MP0002090_abnormal_vision0.63478546
185MP0004043_abnormal_pH_regulation0.63099511
186MP0000371_diluted_coat_color0.62384640
187MP0004087_abnormal_muscle_fiber0.61974601
188MP0003183_abnormal_peptide_metabolism0.59820507
189MP0010770_preweaning_lethality0.59737271
190MP0002082_postnatal_lethality0.59737271
191MP0000627_abnormal_mammary_gland0.59596174
192MP0002254_reproductive_system_inflammat0.59214723
193MP0006036_abnormal_mitochondrial_physio0.58565413
194MP0010769_abnormal_survival0.57820876
195MP0000428_abnormal_craniofacial_morphol0.57524235
196MP0002405_respiratory_system_inflammati0.57041629
197MP0005220_abnormal_exocrine_pancreas0.56583628

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.95576533
2Myokymia (HP:0002411)5.25709836
3Febrile seizures (HP:0002373)5.08412906
4Atonic seizures (HP:0010819)5.03256996
5Focal seizures (HP:0007359)5.02549708
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.99834828
7Epileptic encephalopathy (HP:0200134)4.93004071
8Chromsome breakage (HP:0040012)4.59425364
9Visual hallucinations (HP:0002367)4.55422667
10Absence seizures (HP:0002121)4.20523517
11Progressive cerebellar ataxia (HP:0002073)4.04819137
12Dialeptic seizures (HP:0011146)3.83352308
13Generalized tonic-clonic seizures (HP:0002069)3.50376212
14Hyperventilation (HP:0002883)3.22738100
15Abnormality of chromosome stability (HP:0003220)3.22391185
16Broad-based gait (HP:0002136)3.18484845
17Microvesicular hepatic steatosis (HP:0001414)3.14326026
18Ependymoma (HP:0002888)3.12391585
19Abnormality of the preputium (HP:0100587)3.09864391
20Pheochromocytoma (HP:0002666)3.04426851
21Limb dystonia (HP:0002451)3.03803819
22Action tremor (HP:0002345)2.98647187
23Failure to thrive in infancy (HP:0001531)2.87272678
24Truncal ataxia (HP:0002078)2.86738626
25Prominent nose (HP:0000448)2.85716272
26Gaze-evoked nystagmus (HP:0000640)2.83951480
27Progressive muscle weakness (HP:0003323)2.83083149
28Ankle clonus (HP:0011448)2.82846074
29Neuroendocrine neoplasm (HP:0100634)2.81268359
30Abnormality of the labia minora (HP:0012880)2.78670674
31Gait imbalance (HP:0002141)2.76385603
32Abnormal eating behavior (HP:0100738)2.75366268
33Abnormal hair whorl (HP:0010721)2.72855158
34Impaired vibration sensation in the lower limbs (HP:0002166)2.71203353
35Drooling (HP:0002307)2.67893784
36Excessive salivation (HP:0003781)2.67893784
37Deep philtrum (HP:0002002)2.66634366
38IgA deficiency (HP:0002720)2.64716703
39Fetal akinesia sequence (HP:0001989)2.64170873
40Progressive inability to walk (HP:0002505)2.62525280
41Rhabdomyosarcoma (HP:0002859)2.62104743
42Ectopic kidney (HP:0000086)2.62000346
43Myelodysplasia (HP:0002863)2.61395490
44Dysdiadochokinesis (HP:0002075)2.60583413
45Depression (HP:0000716)2.60365572
46Urinary bladder sphincter dysfunction (HP:0002839)2.60273695
47Birth length less than 3rd percentile (HP:0003561)2.56423756
48Polyphagia (HP:0002591)2.55714552
49Epileptiform EEG discharges (HP:0011182)2.55703273
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.52014807
51Abnormality of the corticospinal tract (HP:0002492)2.50053389
52Poor eye contact (HP:0000817)2.48421595
53Multiple enchondromatosis (HP:0005701)2.47960564
54Abnormality of the astrocytes (HP:0100707)2.47876675
55Astrocytoma (HP:0009592)2.47876675
56Anxiety (HP:0000739)2.47352062
57EEG with generalized epileptiform discharges (HP:0011198)2.47015008
58Abnormality of the ileum (HP:0001549)2.44985224
59Meckel diverticulum (HP:0002245)2.44474820
60Proximal placement of thumb (HP:0009623)2.43950077
61Deviation of the thumb (HP:0009603)2.42757157
62Squamous cell carcinoma (HP:0002860)2.42355868
63Volvulus (HP:0002580)2.41126936
64Nephroblastoma (Wilms tumor) (HP:0002667)2.40689866
65Amblyopia (HP:0000646)2.39613651
66Septate vagina (HP:0001153)2.38290758
67Progressive external ophthalmoplegia (HP:0000590)2.38118318
68Prostate neoplasm (HP:0100787)2.36907781
69Supranuclear gaze palsy (HP:0000605)2.36809976
70Congenital primary aphakia (HP:0007707)2.33995108
71Viral hepatitis (HP:0006562)2.32741700
72Hypsarrhythmia (HP:0002521)2.31001271
73Termporal pattern (HP:0011008)2.29445585
74Insidious onset (HP:0003587)2.29445585
75Subacute progressive viral hepatitis (HP:0006572)2.28633058
76Impaired social interactions (HP:0000735)2.28168479
77Abnormal social behavior (HP:0012433)2.28168479
78Increased mean platelet volume (HP:0011877)2.27303603
79Scanning speech (HP:0002168)2.26815699
80Specific learning disability (HP:0001328)2.26376477
81Abnormality of binocular vision (HP:0011514)2.25561229
82Diplopia (HP:0000651)2.25561229
83Poor suck (HP:0002033)2.24682740
84Bradykinesia (HP:0002067)2.24462005
85Mutism (HP:0002300)2.24253443
86Inability to walk (HP:0002540)2.21868981
87Cafe-au-lait spot (HP:0000957)2.21281061
88Medial flaring of the eyebrow (HP:0010747)2.21045323
89Embryonal renal neoplasm (HP:0011794)2.20219359
90Hemiparesis (HP:0001269)2.19984996
91IgM deficiency (HP:0002850)2.19978008
92Glioma (HP:0009733)2.19358622
93Spastic gait (HP:0002064)2.17849574
94Absent speech (HP:0001344)2.17382336
95Clubbing of toes (HP:0100760)2.17345568
96Impaired smooth pursuit (HP:0007772)2.17090334
97Nephrogenic diabetes insipidus (HP:0009806)2.16062572
98Urinary urgency (HP:0000012)2.15691737
99Neoplasm of the adrenal cortex (HP:0100641)2.14955387
100Protruding tongue (HP:0010808)2.14744089
101Hypothermia (HP:0002045)2.14240749
102Sparse lateral eyebrow (HP:0005338)2.13918581
103Genetic anticipation (HP:0003743)2.13604838
104Medulloblastoma (HP:0002885)2.13175804
105Abnormality of DNA repair (HP:0003254)2.11274016
106Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.11031037
107Dysmetria (HP:0001310)2.10487559
108Acute myeloid leukemia (HP:0004808)2.10380091
109Premature ovarian failure (HP:0008209)2.09838855
110Postural instability (HP:0002172)2.09387115
111Entropion (HP:0000621)2.08735571
112Abnormal platelet volume (HP:0011876)2.07294046
113Abnormality of the lower motor neuron (HP:0002366)2.06577457
114Abnormality of the carotid arteries (HP:0005344)2.06073108
115Small intestinal stenosis (HP:0012848)2.04288714
116Duodenal stenosis (HP:0100867)2.04288714
117Recurrent viral infections (HP:0004429)2.03709362
118Hypoventilation (HP:0002791)2.00061147
119Resting tremor (HP:0002322)1.99761950
120Akinesia (HP:0002304)1.99752683
121Spastic diplegia (HP:0001264)1.99161001
122Poikiloderma (HP:0001029)1.98790796
123Abnormality of the fingertips (HP:0001211)1.96848201
124Degeneration of the lateral corticospinal tracts (HP:0002314)1.95030088
125Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.95030088
126Aplasia/Hypoplasia of the thymus (HP:0010515)1.94712279
127Homocystinuria (HP:0002156)1.94548579
128Abnormality of homocysteine metabolism (HP:0010919)1.94548579
129Sloping forehead (HP:0000340)1.94285480
130Blue irides (HP:0000635)1.93923766
131Papilledema (HP:0001085)1.93273134
132Agitation (HP:0000713)1.93109873
133Abnormality of methionine metabolism (HP:0010901)1.92893922
134Rough bone trabeculation (HP:0100670)1.92453883
135High pitched voice (HP:0001620)1.92344523
136Hypoplasia of the thymus (HP:0000778)1.91576190
137Cellular immunodeficiency (HP:0005374)1.91162319
138Genital tract atresia (HP:0001827)1.89903001
139Dyschromatopsia (HP:0007641)1.89642748
140Micronodular cirrhosis (HP:0001413)1.89396668
141Abnormality of ocular smooth pursuit (HP:0000617)1.89365590
142Neoplasm of the peripheral nervous system (HP:0100007)1.88788315
143Selective tooth agenesis (HP:0001592)1.87564740
144Aplasia/Hypoplasia of the sacrum (HP:0008517)1.87460475
145Trismus (HP:0000211)1.87190958
146Lower limb muscle weakness (HP:0007340)1.86660337
147Vaginal atresia (HP:0000148)1.86130390
148Long eyelashes (HP:0000527)1.85835245
149Sleep apnea (HP:0010535)1.84524567
150Duplicated collecting system (HP:0000081)1.83254753
151Abnormality of salivation (HP:0100755)1.82581890
152Abnormality of pain sensation (HP:0010832)1.80750321
153Impaired pain sensation (HP:0007328)1.80750321
154Hyperthyroidism (HP:0000836)1.79821922
155Shoulder girdle muscle weakness (HP:0003547)1.78822070
156Incomplete penetrance (HP:0003829)1.78316647
157Amyotrophic lateral sclerosis (HP:0007354)1.77620720
158Generalized hypotonia (HP:0001290)1.77165424
159Narrow nasal bridge (HP:0000446)1.76758371
160Sandal gap (HP:0001852)1.76492882
161Short thumb (HP:0009778)1.76437193
162Horseshoe kidney (HP:0000085)1.76307521
163Long foot (HP:0001833)1.74227859
164Fatigue (HP:0012378)1.73810030
165Torticollis (HP:0000473)1.73421543
166Ureteral duplication (HP:0000073)1.72743173
167Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.72548371
168Generalized myoclonic seizures (HP:0002123)1.72383977
169Autoimmune hemolytic anemia (HP:0001890)1.72342692
170Type I transferrin isoform profile (HP:0003642)1.71479516
171Neoplasm of the pancreas (HP:0002894)1.71384120
172Poor coordination (HP:0002370)1.71173344
173Panhypogammaglobulinemia (HP:0003139)1.70748958
174Amaurosis fugax (HP:0100576)1.70685896
175Increased nuchal translucency (HP:0010880)1.70656582
176Impaired vibratory sensation (HP:0002495)1.70550304
177Hypergonadotropic hypogonadism (HP:0000815)1.70426696
178Acute lymphatic leukemia (HP:0006721)1.70274708
179Short nail (HP:0001799)1.70186431
180Abnormality of the thymus (HP:0000777)1.70120774
181Pelvic girdle muscle weakness (HP:0003749)1.69726398
182Neoplasm of striated muscle (HP:0009728)1.67036118
183Absent thumb (HP:0009777)1.66872760
184Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.65688800
185Abnormal protein N-linked glycosylation (HP:0012347)1.65688800
186Abnormal protein glycosylation (HP:0012346)1.65688800
187Abnormal glycosylation (HP:0012345)1.65688800
188Gait ataxia (HP:0002066)1.65079579
189Colon cancer (HP:0003003)1.65027833
190Lymphoma (HP:0002665)1.64976584
191Central scotoma (HP:0000603)1.64702182
192Esotropia (HP:0000565)1.64451865
193Gastroesophageal reflux (HP:0002020)1.64123481
194Choanal atresia (HP:0000453)1.63746936
195Pancreatic islet-cell hyperplasia (HP:0004510)1.63017403
196Abnormality of glycolysis (HP:0004366)1.62497148
197Hyperacusis (HP:0010780)1.62351031
198Leiomyosarcoma (HP:0100243)1.61934958
199Uterine leiomyosarcoma (HP:0002891)1.61934958
200Arteriovenous malformation (HP:0100026)1.61453859

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.33881700
2NTRK34.11804017
3MARK13.64723530
4SRPK13.33933306
5MAP3K43.28786495
6CDC73.15919925
7MAP2K73.06321114
8BUB12.98835554
9CDK122.97479388
10ZAK2.92906045
11SMG12.92886230
12MAP3K122.92219245
13MAP3K92.90604785
14MINK12.72365046
15PBK2.65236292
16TAF12.62565712
17EIF2AK12.51145601
18EPHA42.38252385
19VRK22.23622422
20AKT32.18342361
21NTRK22.13176515
22VRK11.97646893
23PLK21.95520212
24TTK1.92910282
25TLK11.90934247
26IRAK31.85530649
27MAP2K41.77255808
28PRPF4B1.76564286
29CAMK1D1.72967740
30PNCK1.68599053
31CDK81.66529593
32MAPK131.65301269
33EEF2K1.63329244
34CHEK21.60139895
35ATR1.58605766
36NTRK11.58018777
37PAK61.55115884
38SGK21.51979841
39STK41.51379336
40AURKB1.48645819
41DAPK21.48602977
42MST1R1.48337106
43MST41.48247053
44GRK51.45086855
45SGK4941.42183684
46SGK2231.42183684
47CAMK1G1.38715008
48CDK191.37745272
49PDK21.36766420
50DAPK11.33188574
51CDK51.33143402
52TSSK61.31007736
53PRKCG1.30193886
54BRSK21.29788143
55CHEK11.28896499
56NME21.26757695
57RPS6KB21.26684775
58NUAK11.25793676
59KSR11.23474354
60UHMK11.23166399
61CDK71.22065631
62ICK1.21090562
63CDK41.18948189
64MELK1.16776885
65EIF2AK31.14585307
66TNIK1.14472387
67CAMKK11.10563188
68CAMKK21.10141761
69RPS6KA51.09298621
70TTN1.08875771
71TRIB31.08319331
72PLK11.06070136
73AURKA1.05024239
74PHKG21.04453492
75PHKG11.04453492
76NEK11.03144074
77SIK31.01230695
78SGK30.99411196
79CDK90.98209714
80CAMK2A0.97450266
81TEC0.97066382
82ARAF0.96527006
83ATM0.96374181
84MKNK10.95314752
85KSR20.94729857
86MTOR0.94123389
87LATS20.92990008
88BCR0.92796808
89CDK180.92543087
90MAP3K100.91549291
91CCNB10.91108410
92CDK140.90546156
93ERBB30.90340813
94STK100.89653201
95PRKD30.88961563
96OXSR10.87767529
97CDK150.85301401
98PIK3CG0.84749006
99NME10.83981024
100BRD40.83742438
101DYRK1A0.83341296
102CSNK1G20.81974105
103MAP3K80.79673371
104EIF2AK20.79513076
105STK160.79249421
106CAMK2B0.78644057
107MAP3K20.78200123
108BMPR20.77144602
109SCYL20.77067484
110WNK30.76447700
111BTK0.76260145
112TNK20.76019744
113PRKCE0.75860467
114PLK30.75076691
115MAP2K30.74693700
116BMPR1B0.72770300
117CDK11A0.71031557
118STK380.70539481
119MAPK110.70224808
120MKNK20.67470756
121BRAF0.67360766
122SGK10.65851292
123PKN20.65669784
124PINK10.65115171
125PLK40.65004251
126LIMK10.64504454
127IRAK40.64364577
128MAPKAPK50.64029748
129PRKCH0.63146121
130FER0.62707508
131LMTK20.61424122
132INSRR0.60385167
133PAK30.60306811
134RAF10.60270802
135FES0.60138058
136NEK60.59703187
137CDK10.59192741
138MAP3K140.59155989
139PIM10.58587927
140CAMK2D0.57359485
141PIM20.57349213
142ALK0.57311100
143CDK20.56710659
144PAK40.56208686
145RIPK40.56164711
146RPS6KA20.55029247
147TRPM70.50842793
148SIK20.50797891
149ADRBK20.50765884
150CSNK1G30.50410868
151DAPK30.50093710
152CAMK10.50054862
153MUSK0.49618509
154STK110.48835642
155NEK20.48266430
156PDK40.47323510
157PDK30.47323510
158BMX0.47065549
159MAPK100.46901300
160BRSK10.46705504
161IRAK10.46474115
162CSNK2A20.46285840
163DYRK20.45500262
164CDC42BPA0.44766706
165RPS6KB10.44676129
166RPS6KA30.43565546
167CAMK2G0.43108179
168ERBB40.43080271
169YES10.42528856
170IRAK20.41990225
171GRK70.41686900
172ADRBK10.41623917
173SIK10.40956976
174RET0.40747832
175CDK30.40256512
176PRKCI0.39920383
177FRK0.38317201
178WNK10.37062888
179ROCK20.36607360
180CSNK1A1L0.34412163
181CLK10.33516871
182MAP4K10.33419284
183MARK30.33116501
184CDK60.31106021
185CHUK0.30687675
186PRKDC0.29782662
187RPS6KA40.27863400
188BLK0.27071846
189IKBKB0.26483226
190CSNK1E0.26247258

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.13101160
2Nicotine addiction_Homo sapiens_hsa050334.12945446
3DNA replication_Homo sapiens_hsa030304.04120919
4* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.87310808
5Non-homologous end-joining_Homo sapiens_hsa034503.66424270
6Mismatch repair_Homo sapiens_hsa034303.38508232
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.37121901
8Systemic lupus erythematosus_Homo sapiens_hsa053223.09604170
9GABAergic synapse_Homo sapiens_hsa047272.94329135
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.80061399
11RNA polymerase_Homo sapiens_hsa030202.73462903
12Olfactory transduction_Homo sapiens_hsa047402.70596447
13Homologous recombination_Homo sapiens_hsa034402.64675231
14Morphine addiction_Homo sapiens_hsa050322.58050135
15Circadian entrainment_Homo sapiens_hsa047132.58045843
16RNA transport_Homo sapiens_hsa030132.57045363
17Collecting duct acid secretion_Homo sapiens_hsa049662.47034096
18Spliceosome_Homo sapiens_hsa030402.46766137
19Base excision repair_Homo sapiens_hsa034102.46493656
20One carbon pool by folate_Homo sapiens_hsa006702.40159406
21Long-term potentiation_Homo sapiens_hsa047202.35768805
22Nucleotide excision repair_Homo sapiens_hsa034202.30027822
23Amphetamine addiction_Homo sapiens_hsa050312.28739813
24Glutamatergic synapse_Homo sapiens_hsa047242.28348540
25Cell cycle_Homo sapiens_hsa041102.27470119
26Dopaminergic synapse_Homo sapiens_hsa047282.23884037
27Proteasome_Homo sapiens_hsa030502.23790636
28Fanconi anemia pathway_Homo sapiens_hsa034602.10050307
29Pyrimidine metabolism_Homo sapiens_hsa002402.08741395
30Insulin secretion_Homo sapiens_hsa049112.08607176
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.07230140
32Taste transduction_Homo sapiens_hsa047422.04944435
33Serotonergic synapse_Homo sapiens_hsa047261.92254132
34Cholinergic synapse_Homo sapiens_hsa047251.85269814
35Salivary secretion_Homo sapiens_hsa049701.84432914
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.83276024
37Viral carcinogenesis_Homo sapiens_hsa052031.77526689
38Vibrio cholerae infection_Homo sapiens_hsa051101.69954290
39Long-term depression_Homo sapiens_hsa047301.68619192
40Cocaine addiction_Homo sapiens_hsa050301.61756603
41Gastric acid secretion_Homo sapiens_hsa049711.56212190
42Basal transcription factors_Homo sapiens_hsa030221.53766273
43Renin secretion_Homo sapiens_hsa049241.47258544
44RNA degradation_Homo sapiens_hsa030181.46548740
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45301880
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43354961
47mRNA surveillance pathway_Homo sapiens_hsa030151.42681577
48Calcium signaling pathway_Homo sapiens_hsa040201.40939688
49Lysine degradation_Homo sapiens_hsa003101.39602374
50Selenocompound metabolism_Homo sapiens_hsa004501.39495036
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39068502
52Oxytocin signaling pathway_Homo sapiens_hsa049211.38846804
53Phototransduction_Homo sapiens_hsa047441.37049401
54Purine metabolism_Homo sapiens_hsa002301.31162785
55Gap junction_Homo sapiens_hsa045401.30463344
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24724675
57Thyroid cancer_Homo sapiens_hsa052161.20089079
58GnRH signaling pathway_Homo sapiens_hsa049121.16941272
59Non-small cell lung cancer_Homo sapiens_hsa052231.15013926
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11409703
61Biosynthesis of amino acids_Homo sapiens_hsa012301.11355844
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.08473238
63Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07634424
64Axon guidance_Homo sapiens_hsa043601.04427533
65Oocyte meiosis_Homo sapiens_hsa041141.03990089
66ErbB signaling pathway_Homo sapiens_hsa040121.03601561
67Cysteine and methionine metabolism_Homo sapiens_hsa002701.03529733
68Pentose phosphate pathway_Homo sapiens_hsa000301.02703830
69Type II diabetes mellitus_Homo sapiens_hsa049301.01431564
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00739454
71cAMP signaling pathway_Homo sapiens_hsa040241.00639354
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99721352
73Alcoholism_Homo sapiens_hsa050340.98832812
74Estrogen signaling pathway_Homo sapiens_hsa049150.98489739
75Epstein-Barr virus infection_Homo sapiens_hsa051690.96361844
76Cardiac muscle contraction_Homo sapiens_hsa042600.96307242
77Chronic myeloid leukemia_Homo sapiens_hsa052200.94689591
78Type I diabetes mellitus_Homo sapiens_hsa049400.94425542
79Melanogenesis_Homo sapiens_hsa049160.93691203
80p53 signaling pathway_Homo sapiens_hsa041150.93045611
81Oxidative phosphorylation_Homo sapiens_hsa001900.92185077
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91179684
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91035558
84Glioma_Homo sapiens_hsa052140.86935522
85Pancreatic cancer_Homo sapiens_hsa052120.83608447
86MicroRNAs in cancer_Homo sapiens_hsa052060.82898911
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81460703
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80213042
89Primary immunodeficiency_Homo sapiens_hsa053400.79237317
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76683473
91Herpes simplex infection_Homo sapiens_hsa051680.75718228
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.75146669
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.75106920
94Small cell lung cancer_Homo sapiens_hsa052220.73833317
95Acute myeloid leukemia_Homo sapiens_hsa052210.73493195
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72904009
97Prostate cancer_Homo sapiens_hsa052150.70955068
98Apoptosis_Homo sapiens_hsa042100.70473341
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69268145
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68763772
101MAPK signaling pathway_Homo sapiens_hsa040100.68693263
102Carbon metabolism_Homo sapiens_hsa012000.68513828
103Parkinsons disease_Homo sapiens_hsa050120.68188507
104Alzheimers disease_Homo sapiens_hsa050100.67468610
105Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66140042
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65006558
107Bladder cancer_Homo sapiens_hsa052190.63450017
108N-Glycan biosynthesis_Homo sapiens_hsa005100.62687022
109Hepatitis B_Homo sapiens_hsa051610.62039813
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61532406
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61450339
112Thyroid hormone synthesis_Homo sapiens_hsa049180.61263677
113Measles_Homo sapiens_hsa051620.61168101
114Fatty acid biosynthesis_Homo sapiens_hsa000610.60551598
115Endometrial cancer_Homo sapiens_hsa052130.60395273
116HTLV-I infection_Homo sapiens_hsa051660.60074341
117Pancreatic secretion_Homo sapiens_hsa049720.59851550
118Pyruvate metabolism_Homo sapiens_hsa006200.59452620
119Dilated cardiomyopathy_Homo sapiens_hsa054140.59170434
120Circadian rhythm_Homo sapiens_hsa047100.58562103
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58480090
122Inositol phosphate metabolism_Homo sapiens_hsa005620.58199956
123Ras signaling pathway_Homo sapiens_hsa040140.57344378
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55744261
125Huntingtons disease_Homo sapiens_hsa050160.55604516
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54661798
127Rheumatoid arthritis_Homo sapiens_hsa053230.54048433
128Platelet activation_Homo sapiens_hsa046110.53705394
129Wnt signaling pathway_Homo sapiens_hsa043100.53641233
130B cell receptor signaling pathway_Homo sapiens_hsa046620.53370716
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.53289165
132Adherens junction_Homo sapiens_hsa045200.52976097
133Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51561021
134Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51420033
135Dorso-ventral axis formation_Homo sapiens_hsa043200.51183573
136NF-kappa B signaling pathway_Homo sapiens_hsa040640.50589074
137Glucagon signaling pathway_Homo sapiens_hsa049220.50386065
1382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49590583
139Choline metabolism in cancer_Homo sapiens_hsa052310.48595782
140Legionellosis_Homo sapiens_hsa051340.48529539
141Phospholipase D signaling pathway_Homo sapiens_hsa040720.47901995
142Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46854066
143Melanoma_Homo sapiens_hsa052180.46244552
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45443266
145Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44615930
146Phagosome_Homo sapiens_hsa041450.43736463
147Colorectal cancer_Homo sapiens_hsa052100.43076524
148Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41858130
149Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39839706
150mTOR signaling pathway_Homo sapiens_hsa041500.39506688
151Rap1 signaling pathway_Homo sapiens_hsa040150.39269020
152T cell receptor signaling pathway_Homo sapiens_hsa046600.38921632
153Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38390058
154Ribosome_Homo sapiens_hsa030100.37940445
155Vitamin B6 metabolism_Homo sapiens_hsa007500.37747941
156Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37087382
157Insulin signaling pathway_Homo sapiens_hsa049100.35616987
158HIF-1 signaling pathway_Homo sapiens_hsa040660.34693447
159Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34368305
160Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34354434
161Jak-STAT signaling pathway_Homo sapiens_hsa046300.33187359
162Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32933575
163Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31943254
164Renal cell carcinoma_Homo sapiens_hsa052110.31469512
165FoxO signaling pathway_Homo sapiens_hsa040680.31355753
166Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31072581
167Sulfur relay system_Homo sapiens_hsa041220.30641768
168Endocytosis_Homo sapiens_hsa041440.30636673
169Sulfur metabolism_Homo sapiens_hsa009200.30419031
170Hedgehog signaling pathway_Homo sapiens_hsa043400.30336367
171Sphingolipid signaling pathway_Homo sapiens_hsa040710.30213643
172Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29773779
173TGF-beta signaling pathway_Homo sapiens_hsa043500.29571861
174Ovarian steroidogenesis_Homo sapiens_hsa049130.29243463
175Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28733423
176Galactose metabolism_Homo sapiens_hsa000520.28338519
177Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28250685
178Prion diseases_Homo sapiens_hsa050200.28250618
179Notch signaling pathway_Homo sapiens_hsa043300.27276424
180Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27239875
181Proteoglycans in cancer_Homo sapiens_hsa052050.26900498
182Regulation of autophagy_Homo sapiens_hsa041400.26628101
183Influenza A_Homo sapiens_hsa051640.26554749
184Hepatitis C_Homo sapiens_hsa051600.26409001
185Insulin resistance_Homo sapiens_hsa049310.25237100

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