GNG3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The gamma subunit determines the specificity of which signaling pathways will be affected by this particular complex. The protein encoded by this gene represents the gamma subunit of both inhibitory and stimulatory complexes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.84890870
2neuron cell-cell adhesion (GO:0007158)5.56877560
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.30157751
4glutamate secretion (GO:0014047)5.25642865
5vocalization behavior (GO:0071625)4.97164969
6regulation of synaptic vesicle exocytosis (GO:2000300)4.86988123
7protein localization to synapse (GO:0035418)4.72789652
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.70746442
9synaptic vesicle maturation (GO:0016188)4.68386596
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.60245785
11nucleobase catabolic process (GO:0046113)4.47864906
12neuronal action potential propagation (GO:0019227)4.44204326
13neuronal ion channel clustering (GO:0045161)4.30901975
14neurotransmitter secretion (GO:0007269)4.29303704
15regulation of glutamate receptor signaling pathway (GO:1900449)4.28871634
16regulation of synaptic vesicle transport (GO:1902803)4.26893644
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.26206363
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.23001277
19synaptic vesicle docking involved in exocytosis (GO:0016081)4.20716084
20auditory behavior (GO:0031223)4.14947679
21establishment of mitochondrion localization (GO:0051654)4.10402297
22dendritic spine morphogenesis (GO:0060997)4.04953153
23cell migration in hindbrain (GO:0021535)4.04566055
24behavioral response to nicotine (GO:0035095)4.03841820
25locomotory exploration behavior (GO:0035641)3.97728457
26neurofilament cytoskeleton organization (GO:0060052)3.91565837
27presynaptic membrane assembly (GO:0097105)3.90656403
28neuron-neuron synaptic transmission (GO:0007270)3.81668415
29negative regulation of dendrite morphogenesis (GO:0050774)3.80972583
30positive regulation of dendritic spine morphogenesis (GO:0061003)3.76412433
31ionotropic glutamate receptor signaling pathway (GO:0035235)3.73301016
32presynaptic membrane organization (GO:0097090)3.72450768
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.72038416
34synaptic transmission, glutamatergic (GO:0035249)3.70491959
35exploration behavior (GO:0035640)3.70089582
36postsynaptic membrane organization (GO:0001941)3.67458908
37negative regulation of synaptic transmission, GABAergic (GO:0032229)3.66504575
38negative regulation of microtubule polymerization (GO:0031115)3.60058147
39positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.59881809
40neurotransmitter-gated ion channel clustering (GO:0072578)3.59120400
41ATP hydrolysis coupled proton transport (GO:0015991)3.59042105
42energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.59042105
43positive regulation of synaptic transmission, GABAergic (GO:0032230)3.57007104
44neuron recognition (GO:0008038)3.54319148
45neurotransmitter transport (GO:0006836)3.52173284
46proline transport (GO:0015824)3.51420260
47transferrin transport (GO:0033572)3.50295810
48cellular potassium ion homeostasis (GO:0030007)3.47798540
49glutamate receptor signaling pathway (GO:0007215)3.42375790
50regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.39800250
51cerebellar granule cell differentiation (GO:0021707)3.37298598
52regulation of neuronal synaptic plasticity (GO:0048168)3.36604481
53positive regulation of synapse assembly (GO:0051965)3.35405574
54chaperone-mediated protein transport (GO:0072321)3.34685525
55regulation of neurotransmitter secretion (GO:0046928)3.33959051
56negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.32932134
57mitochondrion transport along microtubule (GO:0047497)3.32306019
58establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.32306019
59synaptic vesicle endocytosis (GO:0048488)3.32139147
60regulation of neurotransmitter levels (GO:0001505)3.31993104
61regulation of voltage-gated calcium channel activity (GO:1901385)3.31360655
62positive regulation of dendritic spine development (GO:0060999)3.31114277
63regulation of dendritic spine morphogenesis (GO:0061001)3.27796977
64response to auditory stimulus (GO:0010996)3.27090769
65regulation of long-term neuronal synaptic plasticity (GO:0048169)3.26204619
66regulation of vesicle fusion (GO:0031338)3.26028070
67cerebellar Purkinje cell differentiation (GO:0021702)3.25112829
68negative regulation of dendrite development (GO:2000171)3.24650594
69regulation of synapse structural plasticity (GO:0051823)3.23318102
70trivalent inorganic cation transport (GO:0072512)3.23293062
71ferric iron transport (GO:0015682)3.23293062
72membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.22128368
73gamma-aminobutyric acid signaling pathway (GO:0007214)3.21674013
74mechanosensory behavior (GO:0007638)3.21399043
75positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.21319200
76gamma-aminobutyric acid transport (GO:0015812)3.19238135
77regulation of excitatory postsynaptic membrane potential (GO:0060079)3.18991484
78positive regulation of synapse maturation (GO:0090129)3.18879428
79synaptic vesicle transport (GO:0048489)3.18236615
80establishment of synaptic vesicle localization (GO:0097480)3.18236615
81regulation of neurotransmitter transport (GO:0051588)3.17620687
82activation of protein kinase A activity (GO:0034199)3.14348338
83regulation of postsynaptic membrane potential (GO:0060078)3.13974603
84synapse assembly (GO:0007416)3.11862435
85layer formation in cerebral cortex (GO:0021819)3.10646482
86central nervous system myelination (GO:0022010)3.09606803
87axon ensheathment in central nervous system (GO:0032291)3.09606803
88positive regulation of neurotransmitter transport (GO:0051590)3.07752516
89axonal fasciculation (GO:0007413)3.07650920
90positive regulation of membrane potential (GO:0045838)3.07487103
91innervation (GO:0060384)3.07051906
92regulation of synaptic transmission, glutamatergic (GO:0051966)3.05658501
93dendrite morphogenesis (GO:0048813)3.04978506
94neuromuscular process controlling posture (GO:0050884)3.03960222
95neuromuscular synaptic transmission (GO:0007274)3.03190089
96substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.02833855
97substrate-independent telencephalic tangential migration (GO:0021826)3.02833855
98long-term synaptic potentiation (GO:0060291)3.02569429
99pyrimidine nucleobase catabolic process (GO:0006208)3.02036784
100membrane depolarization during action potential (GO:0086010)3.01235896
101prepulse inhibition (GO:0060134)3.00767885
102regulation of synaptic transmission, GABAergic (GO:0032228)2.99940614
103short-term memory (GO:0007614)2.99637990
104behavioral defense response (GO:0002209)2.98975799
105behavioral fear response (GO:0001662)2.98975799
106synapse organization (GO:0050808)2.98283291
107regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.98059885
108long-term memory (GO:0007616)2.97643382
109cell differentiation in hindbrain (GO:0021533)2.96102484
110* synaptic transmission (GO:0007268)2.95938525
111sequestering of actin monomers (GO:0042989)2.95663930
112dendritic spine organization (GO:0097061)2.94295320
113sodium ion export (GO:0071436)2.93265046
114membrane depolarization (GO:0051899)2.92436625
115response to histamine (GO:0034776)2.92280769
116establishment of vesicle localization (GO:0051650)2.92248320
117G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.91553872
118startle response (GO:0001964)2.90826119
119fear response (GO:0042596)2.89431413
120striatum development (GO:0021756)2.88925719
121regulation of synaptic plasticity (GO:0048167)2.88919920
122membrane hyperpolarization (GO:0060081)2.88594785
123behavioral response to cocaine (GO:0048148)2.87851337
124regulation of protein kinase A signaling (GO:0010738)2.87630330
125response to cocaine (GO:0042220)2.86036355
126regulation of glutamate secretion (GO:0014048)2.85760097
127synaptic transmission, dopaminergic (GO:0001963)2.84342287
128transmission of nerve impulse (GO:0019226)2.83973732
129adult walking behavior (GO:0007628)2.81362272
130regulation of synapse assembly (GO:0051963)2.81247889
131mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.81138634

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.95607611
2GBX2_23144817_ChIP-Seq_PC3_Human4.31868468
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19424881
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03272607
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93269824
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.86394635
7REST_21632747_ChIP-Seq_MESCs_Mouse2.77567144
8TAF15_26573619_Chip-Seq_HEK293_Human2.71417811
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64909215
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.63544714
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56007196
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56007196
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53877417
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49334801
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47101726
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.40662628
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35908929
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.33688132
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32444998
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.29832418
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.28943341
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.26038906
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.15802173
24BMI1_23680149_ChIP-Seq_NPCS_Mouse2.13852323
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.13738178
26CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06109796
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02223681
28* RARB_27405468_Chip-Seq_BRAIN_Mouse2.02134232
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.98583719
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97788274
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.74158133
32DROSHA_22980978_ChIP-Seq_HELA_Human1.72031688
33SMAD4_21799915_ChIP-Seq_A2780_Human1.70743624
34AR_21572438_ChIP-Seq_LNCaP_Human1.70625881
35P300_19829295_ChIP-Seq_ESCs_Human1.68401131
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66579171
37IGF1R_20145208_ChIP-Seq_DFB_Human1.65169922
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.64187588
39VDR_22108803_ChIP-Seq_LS180_Human1.64080727
40RNF2_27304074_Chip-Seq_NSC_Mouse1.62802698
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60635850
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56920329
43ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.50175190
44ZNF274_21170338_ChIP-Seq_K562_Hela1.46281799
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.41543232
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41516385
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41383261
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40874095
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39812460
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39648509
51MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36999856
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35322054
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33697167
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33189017
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31660628
56AR_25329375_ChIP-Seq_VCAP_Human1.30719173
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29366037
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.28535409
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27951610
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.25825292
61FUS_26573619_Chip-Seq_HEK293_Human1.23596875
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.22823134
63GATA1_26923725_Chip-Seq_HPCs_Mouse1.21558794
64RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21290716
65CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18959370
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18530073
67ER_23166858_ChIP-Seq_MCF-7_Human1.14163034
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13856609
69JUN_21703547_ChIP-Seq_K562_Human1.13710554
70OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13295626
71FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12943962
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.12839312
73STAT3_23295773_ChIP-Seq_U87_Human1.11931109
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08834425
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.05328254
76CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.04212196
77SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04133170
78RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02562879
79TCF4_23295773_ChIP-Seq_U87_Human1.00632087
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00093982
81RUNX2_22187159_ChIP-Seq_PCA_Human0.99674426
82P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99016495
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97716176
84AR_19668381_ChIP-Seq_PC3_Human0.97106942
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96454659
86DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95957221
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95114678
88CTCF_27219007_Chip-Seq_Bcells_Human0.94891348
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93912183
90YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93578211
91TP53_20018659_ChIP-ChIP_R1E_Mouse0.93551066
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93001077
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91792439
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91792439
95SMAD_19615063_ChIP-ChIP_OVARY_Human0.91551878
96RING1B_27294783_Chip-Seq_NPCs_Mouse0.90827490
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89504012
98ARNT_22903824_ChIP-Seq_MCF-7_Human0.89156441
99LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88725198
100CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88205575
101SMAD3_21741376_ChIP-Seq_ESCs_Human0.88107473
102NANOG_18555785_Chip-Seq_ESCs_Mouse0.88034377
103SOX9_26525672_Chip-Seq_HEART_Mouse0.87362605
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86264512
105AHR_22903824_ChIP-Seq_MCF-7_Human0.85948346
106RBPJ_22232070_ChIP-Seq_NCS_Mouse0.85409149
107KDM2B_26808549_Chip-Seq_REH_Human0.84861412
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83841857
109WT1_25993318_ChIP-Seq_PODOCYTE_Human0.82257879
110THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81483432
111ZFP281_18757296_ChIP-ChIP_E14_Mouse0.79433511
112STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.79175977
113CDX2_19796622_ChIP-Seq_MESCs_Mouse0.79160915

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.87349401
2MP0004859_abnormal_synaptic_plasticity4.84493939
3MP0001968_abnormal_touch/_nociception3.62566467
4MP0004270_analgesia3.62114285
5MP0003635_abnormal_synaptic_transmissio3.56828299
6MP0002735_abnormal_chemical_nociception3.40644664
7MP0006276_abnormal_autonomic_nervous3.30930623
8MP0002736_abnormal_nociception_after3.11726598
9MP0009745_abnormal_behavioral_response3.07439798
10MP0009046_muscle_twitch3.03133093
11MP0002734_abnormal_mechanical_nocicepti2.96088356
12MP0002063_abnormal_learning/memory/cond2.90545923
13* MP0002064_seizures2.88171975
14MP0002572_abnormal_emotion/affect_behav2.69003045
15MP0002733_abnormal_thermal_nociception2.58585005
16MP0002272_abnormal_nervous_system2.55258766
17MP0005423_abnormal_somatic_nervous2.54681204
18MP0001529_abnormal_vocalization2.46368643
19MP0001970_abnormal_pain_threshold2.41544432
20MP0003122_maternal_imprinting2.21954437
21MP0001486_abnormal_startle_reflex2.19033718
22MP0002822_catalepsy2.15885053
23MP0001440_abnormal_grooming_behavior2.14376251
24MP0002067_abnormal_sensory_capabilities2.10387545
25MP0001905_abnormal_dopamine_level2.10329920
26MP0002184_abnormal_innervation2.08964407
27MP0001501_abnormal_sleep_pattern1.98802980
28MP0000778_abnormal_nervous_system1.91901276
29MP0001984_abnormal_olfaction1.89796468
30MP0004858_abnormal_nervous_system1.87872661
31MP0003787_abnormal_imprinting1.87072662
32MP0005386_behavior/neurological_phenoty1.80819423
33MP0004924_abnormal_behavior1.80819423
34MP0002557_abnormal_social/conspecific_i1.75096237
35MP0004811_abnormal_neuron_physiology1.71016416
36MP0001986_abnormal_taste_sensitivity1.67125677
37MP0004142_abnormal_muscle_tone1.64952742
38MP0005646_abnormal_pituitary_gland1.63163244
39MP0000955_abnormal_spinal_cord1.55822268
40MP0001188_hyperpigmentation1.55045351
41MP0002882_abnormal_neuron_morphology1.44635115
42MP0005645_abnormal_hypothalamus_physiol1.44402228
43MP0002066_abnormal_motor_capabilities/c1.36021925
44MP0003879_abnormal_hair_cell1.35420670
45MP0008569_lethality_at_weaning1.35366954
46MP0003123_paternal_imprinting1.29475874
47MP0002102_abnormal_ear_morphology1.24728005
48MP0003329_amyloid_beta_deposits1.23941682
49MP0010386_abnormal_urinary_bladder1.22353397
50MP0000751_myopathy1.19073657
51MP0002909_abnormal_adrenal_gland1.18339518
52MP0002837_dystrophic_cardiac_calcinosis1.17241784
53MP0001502_abnormal_circadian_rhythm1.15669992
54MP0000569_abnormal_digit_pigmentation1.15469201
55MP0002751_abnormal_autonomic_nervous1.14071547
56MP0002638_abnormal_pupillary_reflex1.12913049
57MP0009780_abnormal_chondrocyte_physiolo1.10610526
58MP0008872_abnormal_physiological_respon1.10465311
59MP0005499_abnormal_olfactory_system1.05140996
60MP0005394_taste/olfaction_phenotype1.05140996
61MP0002152_abnormal_brain_morphology1.02556147
62MP0004742_abnormal_vestibular_system1.00541234
63MP0002752_abnormal_somatic_nervous0.98161165
64MP0002229_neurodegeneration0.95298704
65MP0002876_abnormal_thyroid_physiology0.95289090
66MP0005551_abnormal_eye_electrophysiolog0.91837110
67MP0003121_genomic_imprinting0.91785376
68MP0002069_abnormal_eating/drinking_beha0.90247920
69MP0004133_heterotaxia0.90169875
70MP0001963_abnormal_hearing_physiology0.89444310
71MP0003633_abnormal_nervous_system0.88744679
72MP0003631_nervous_system_phenotype0.86322783
73MP0000631_abnormal_neuroendocrine_gland0.86010790
74MP0005187_abnormal_penis_morphology0.85423541
75MP0001664_abnormal_digestion0.84435528
76MP0003011_delayed_dark_adaptation0.81613076
77MP0008877_abnormal_DNA_methylation0.79147707
78MP0004145_abnormal_muscle_electrophysio0.77187612
79MP0004085_abnormal_heartbeat0.75947613
80MP0005535_abnormal_body_temperature0.75842099
81MP0006292_abnormal_olfactory_placode0.75468430
82MP0002653_abnormal_ependyma_morphology0.74642996
83MP0003646_muscle_fatigue0.71745156
84MP0008874_decreased_physiological_sensi0.71378455
85MP0000566_synostosis0.70824371
86MP0001177_atelectasis0.70422895
87MP0003634_abnormal_glial_cell0.69578275
88MP0008789_abnormal_olfactory_epithelium0.68174878
89MP0005253_abnormal_eye_physiology0.67202619
90MP0004885_abnormal_endolymph0.66725755
91MP0003938_abnormal_ear_development0.66381748
92MP0003890_abnormal_embryonic-extraembry0.65633312
93MP0003183_abnormal_peptide_metabolism0.64526840
94MP0006072_abnormal_retinal_apoptosis0.63150008
95MP0000920_abnormal_myelination0.63091333
96MP0001943_abnormal_respiration0.62796182
97MP0003632_abnormal_nervous_system0.62449916
98MP0008995_early_reproductive_senescence0.62363613
99MP0002928_abnormal_bile_duct0.61873202
100MP0003861_abnormal_nervous_system0.59652843
101MP0005409_darkened_coat_color0.59470855
102MP0000026_abnormal_inner_ear0.58745793
103MP0005195_abnormal_posterior_eye0.57693853
104MP0000538_abnormal_urinary_bladder0.56404133
105MP0003690_abnormal_glial_cell0.54919037
106MP0006035_abnormal_mitochondrial_morpho0.53970953
107MP0001299_abnormal_eye_distance/0.53700283
108MP0010770_preweaning_lethality0.52924795
109MP0002082_postnatal_lethality0.52924795
110MP0004215_abnormal_myocardial_fiber0.52257634
111MP0003137_abnormal_impulse_conducting0.50829175
112MP0010769_abnormal_survival0.50780499
113MP0004233_abnormal_muscle_weight0.50068101
114MP0001485_abnormal_pinna_reflex0.49568352
115MP0002332_abnormal_exercise_endurance0.49450178
116MP0005171_absent_coat_pigmentation0.49093932
117MP0010768_mortality/aging0.48192018

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.08401851
2Focal motor seizures (HP:0011153)6.61721276
3Focal seizures (HP:0007359)4.92076300
4Atonic seizures (HP:0010819)4.89278825
5Epileptic encephalopathy (HP:0200134)4.63080935
6Febrile seizures (HP:0002373)4.44026519
7Limb dystonia (HP:0002451)4.37714284
8Progressive cerebellar ataxia (HP:0002073)4.32466418
9Visual hallucinations (HP:0002367)4.25334579
10Abnormal hair whorl (HP:0010721)3.92325512
11Pheochromocytoma (HP:0002666)3.83516001
12Failure to thrive in infancy (HP:0001531)3.80467062
13Absence seizures (HP:0002121)3.80464073
14Polyphagia (HP:0002591)3.59755712
15Neuroendocrine neoplasm (HP:0100634)3.52390798
16Dialeptic seizures (HP:0011146)3.44743508
17Hyperventilation (HP:0002883)3.35829928
18Generalized tonic-clonic seizures (HP:0002069)3.30028339
19Abnormal eating behavior (HP:0100738)3.18626869
20Acute necrotizing encephalopathy (HP:0006965)3.15468615
21Poor suck (HP:0002033)3.14660095
22Amblyopia (HP:0000646)2.95799684
23Abnormal mitochondria in muscle tissue (HP:0008316)2.90880823
24Broad-based gait (HP:0002136)2.90613705
25Gait imbalance (HP:0002141)2.88149887
26Impaired vibration sensation in the lower limbs (HP:0002166)2.87753445
27Abnormality of the labia minora (HP:0012880)2.84370539
28Hypothermia (HP:0002045)2.84260822
29Progressive macrocephaly (HP:0004481)2.79784695
30Oligomenorrhea (HP:0000876)2.74726287
31Action tremor (HP:0002345)2.73543036
32Ankle clonus (HP:0011448)2.72789245
33Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.72174953
34Degeneration of the lateral corticospinal tracts (HP:0002314)2.72174953
35Hypoventilation (HP:0002791)2.68970216
36Status epilepticus (HP:0002133)2.68827104
37Progressive inability to walk (HP:0002505)2.62003601
38Amyotrophic lateral sclerosis (HP:0007354)2.58276404
39Gaze-evoked nystagmus (HP:0000640)2.54828574
40Mitochondrial inheritance (HP:0001427)2.53886807
41Morphological abnormality of the pyramidal tract (HP:0002062)2.53708218
42Cerebral hypomyelination (HP:0006808)2.51607209
43Specific learning disability (HP:0001328)2.50853657
44Anxiety (HP:0000739)2.49903021
45Diplopia (HP:0000651)2.49852617
46Truncal ataxia (HP:0002078)2.48544441
47Spastic tetraplegia (HP:0002510)2.47552913
48Congenital primary aphakia (HP:0007707)2.45885478
49Supranuclear gaze palsy (HP:0000605)2.45536185
50Medial flaring of the eyebrow (HP:0010747)2.44995396
51Insidious onset (HP:0003587)2.44506589
52Termporal pattern (HP:0011008)2.44506589
53Postural instability (HP:0002172)2.39211338
54Depression (HP:0000716)2.37855014
55Sleep apnea (HP:0010535)2.36378873
56Abnormality of the corticospinal tract (HP:0002492)2.36050649
57Impaired pain sensation (HP:0007328)2.35605216
58Abnormality of pain sensation (HP:0010832)2.35605216
59Esotropia (HP:0000565)2.35006806
60Myotonia (HP:0002486)2.33942911
61Retinal dysplasia (HP:0007973)2.33333812
62Intention tremor (HP:0002080)2.33286523
63Urinary bladder sphincter dysfunction (HP:0002839)2.32552417
64Epileptiform EEG discharges (HP:0011182)2.32476141
65Lissencephaly (HP:0001339)2.31526553
66Hemiparesis (HP:0001269)2.31371187
67Fetal akinesia sequence (HP:0001989)2.30461432
68Neoplasm of the peripheral nervous system (HP:0100007)2.28641879
69Nephrogenic diabetes insipidus (HP:0009806)2.28005393
70Acute encephalopathy (HP:0006846)2.27544196
71Spastic gait (HP:0002064)2.27400084
72Inability to walk (HP:0002540)2.24780819
73Genital tract atresia (HP:0001827)2.24124291
74Dysmetria (HP:0001310)2.23337326
75Excessive salivation (HP:0003781)2.19968224
76Drooling (HP:0002307)2.19968224
77Sensory axonal neuropathy (HP:0003390)2.19443974
78Vaginal atresia (HP:0000148)2.18232873
79EEG with generalized epileptiform discharges (HP:0011198)2.18051708
80Poor eye contact (HP:0000817)2.17063263
81Urinary urgency (HP:0000012)2.16872260
82Hyperthyroidism (HP:0000836)2.15470191
83Narrow nasal bridge (HP:0000446)2.15191892
84Dysdiadochokinesis (HP:0002075)2.14729629
85Aplasia/Hypoplasia of the brainstem (HP:0007362)2.14118502
86Hypoplasia of the brainstem (HP:0002365)2.14118502
87Hepatocellular necrosis (HP:0001404)2.13776279
88Generalized hypotonia (HP:0001290)2.13632974
89Mutism (HP:0002300)2.13067419
90Cortical dysplasia (HP:0002539)2.13049656
91Focal dystonia (HP:0004373)2.09425871
92Increased CSF lactate (HP:0002490)2.07731791
93Hypsarrhythmia (HP:0002521)2.07349352
94Pachygyria (HP:0001302)2.06753997
95Abnormality of glycolysis (HP:0004366)2.04846046
96Increased serum pyruvate (HP:0003542)2.04846046
97Delusions (HP:0000746)2.03988386
98Torticollis (HP:0000473)2.02530903
99Akinesia (HP:0002304)2.02451283
100Impaired vibratory sensation (HP:0002495)2.01655336
101Agitation (HP:0000713)2.00711006
102Abnormal social behavior (HP:0012433)1.99292029
103Impaired social interactions (HP:0000735)1.99292029
104Optic disc pallor (HP:0000543)1.98420332
105Peripheral hypomyelination (HP:0007182)1.98052036
106Absent speech (HP:0001344)1.97085267
107CNS hypomyelination (HP:0003429)1.94581306
108Scanning speech (HP:0002168)1.93604198
109Ulnar claw (HP:0001178)1.92082361
110Muscular hypotonia of the trunk (HP:0008936)1.89664901
111Hypoplasia of the corpus callosum (HP:0002079)1.89263454
112Psychosis (HP:0000709)1.88159526
113Abnormality of the lower motor neuron (HP:0002366)1.87693375
114Neurofibrillary tangles (HP:0002185)1.87428254
115Bradykinesia (HP:0002067)1.86302315
116Incomplete penetrance (HP:0003829)1.84145324
117Craniofacial dystonia (HP:0012179)1.84110346
118Genetic anticipation (HP:0003743)1.83150397
119Poor coordination (HP:0002370)1.81018436
120Impaired smooth pursuit (HP:0007772)1.80487522
121Papilledema (HP:0001085)1.79587874
122Lower limb muscle weakness (HP:0007340)1.78303484
123Abnormality of binocular vision (HP:0011514)1.78025811
124Hemiplegia (HP:0002301)1.76998281
125Hand muscle atrophy (HP:0009130)1.75878637
126Type II lissencephaly (HP:0007260)1.74182260
127Neuronal loss in central nervous system (HP:0002529)1.72829358
128Nephronophthisis (HP:0000090)1.67903016

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.47011212
2MAP3K123.84783133
3NTRK33.52742820
4MARK13.19944097
5MAP3K43.08698363
6MAP2K72.93486276
7MAP3K92.79255200
8MINK12.71192895
9GRK52.51117336
10EPHA42.15681529
11DAPK22.06357624
12PLK22.04467005
13PINK12.03769494
14MAP2K41.97985939
15MAPK131.93771174
16CDK191.91781759
17ARAF1.79691246
18NTRK21.75593222
19SIK31.73068265
20LIMK11.71816627
21DAPK11.67026963
22PAK61.64797080
23NTRK11.44760926
24KSR21.41668129
25PNCK1.34717316
26CDK51.32799327
27UHMK11.31320389
28NME11.30275397
29PRPF4B1.29451177
30KSR11.29244884
31PRKCG1.27519026
32AKT31.26140979
33SGK4941.15021963
34SGK2231.15021963
35MAP4K21.14175915
36BCR1.13135078
37OXSR11.12919672
38CDK181.11878561
39CDK141.11472306
40CCNB11.03313207
41CAMK2A1.03013837
42CSNK1G21.02936249
43BRAF1.02227133
44CDK151.01807946
45TSSK61.00908034
46TRIM281.00267897
47LATS21.00197837
48PHKG10.98800667
49PHKG20.98800667
50CSNK1A1L0.98747221
51PRKD30.94149037
52SGK20.91267839
53CDK11A0.90413904
54DYRK20.89422585
55RIPK40.88582558
56MAP3K110.87482253
57CAMK2B0.87442204
58CSNK1G30.86668760
59TNIK0.86664504
60DYRK1B0.80284475
61BMPR1B0.79794675
62DYRK30.79587596
63CAMKK20.78851192
64GRK70.77129921
65PKN10.76558342
66ADRBK20.74647226
67ADRBK10.73877856
68MAPKAPK50.70589598
69RET0.70023254
70MAP3K20.69866966
71CAMKK10.69320504
72WNK30.68490497
73FES0.68167346
74SIK20.68156612
75CAMK40.65699196
76PRKCE0.64990252
77DYRK1A0.64738929
78NEK10.61205664
79PTK2B0.59579024
80WNK40.57842566
81PAK30.57145849
82CAMK2G0.57105707
83RPS6KA20.56839875
84EPHA30.55895650
85ERBB30.55146444
86MAP2K10.53357485
87TESK10.53235360
88TYRO30.53077028
89DAPK30.52480400
90CAMK2D0.52055832
91LMTK20.50784297
92CAMK1G0.50374055
93FER0.49205387
94MYLK0.47488269
95CAMK10.47189430
96SGK30.45712185
97PRKG10.43637927
98CSNK1G10.43320670
99CSNK1E0.42542817
100PRKCZ0.42521400
101ROCK20.42400690
102RPS6KA30.41821178
103STK390.41208307
104CDK80.40393706
105BMPR20.40304345
106MAP3K60.39720190
107ERBB40.38943467
108STK160.38805986
109SGK10.37854232
110PRKCH0.37515986
111PRKACA0.36931931
112CSNK1A10.36094918
113PDK40.35990834
114PDK30.35990834
115PLK30.35498168
116PRKCA0.35248053
117STK110.35105022
118STK380.34907756
119ALK0.34109404
120CSNK1D0.33412696
121MAPK150.33146980
122MARK20.33102490
123FYN0.32700527
124MAPK40.32583225
125MAPK80.32139092
126TNK20.31785302
127PRKAA10.29896249
128MAPK100.29851389
129ERBB20.29237548
130PRKCB0.29127227

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.46290175
2Nicotine addiction_Homo sapiens_hsa050333.78175596
3Collecting duct acid secretion_Homo sapiens_hsa049663.19264249
4Oxidative phosphorylation_Homo sapiens_hsa001902.86549112
5* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.46821084
6* GABAergic synapse_Homo sapiens_hsa047272.39590904
7Olfactory transduction_Homo sapiens_hsa047402.37597177
8Parkinsons disease_Homo sapiens_hsa050122.35820816
9Amphetamine addiction_Homo sapiens_hsa050312.28171491
10Long-term potentiation_Homo sapiens_hsa047202.24784651
11* Circadian entrainment_Homo sapiens_hsa047132.22236862
12* Morphine addiction_Homo sapiens_hsa050322.12855748
13* Dopaminergic synapse_Homo sapiens_hsa047282.12324379
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.12208458
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.09168432
16* Glutamatergic synapse_Homo sapiens_hsa047242.07321268
17Vibrio cholerae infection_Homo sapiens_hsa051102.05822010
18Taste transduction_Homo sapiens_hsa047422.03628395
19Alzheimers disease_Homo sapiens_hsa050101.87436093
20Insulin secretion_Homo sapiens_hsa049111.80114161
21* Serotonergic synapse_Homo sapiens_hsa047261.78510626
22Salivary secretion_Homo sapiens_hsa049701.74273736
23Cocaine addiction_Homo sapiens_hsa050301.73757681
24* Cholinergic synapse_Homo sapiens_hsa047251.67457767
25Long-term depression_Homo sapiens_hsa047301.66821794
26Cardiac muscle contraction_Homo sapiens_hsa042601.60765660
27Huntingtons disease_Homo sapiens_hsa050161.59160112
28Gastric acid secretion_Homo sapiens_hsa049711.40840192
29Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.34689582
30Gap junction_Homo sapiens_hsa045401.34305436
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32375080
32Renin secretion_Homo sapiens_hsa049241.31676522
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.31596663
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30713327
35Calcium signaling pathway_Homo sapiens_hsa040201.29807365
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28410652
37Oxytocin signaling pathway_Homo sapiens_hsa049211.25149031
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18675500
39Phototransduction_Homo sapiens_hsa047441.18616871
40GnRH signaling pathway_Homo sapiens_hsa049121.14685857
41Axon guidance_Homo sapiens_hsa043601.11559643
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97407994
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92653004
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91165837
45Melanogenesis_Homo sapiens_hsa049160.90916083
46ErbB signaling pathway_Homo sapiens_hsa040120.90767928
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90525513
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88239817
49Oocyte meiosis_Homo sapiens_hsa041140.87341180
50Rheumatoid arthritis_Homo sapiens_hsa053230.87316244
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83945420
52cAMP signaling pathway_Homo sapiens_hsa040240.83660773
53Estrogen signaling pathway_Homo sapiens_hsa049150.83605407
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79349354
55Glioma_Homo sapiens_hsa052140.77492897
56Phagosome_Homo sapiens_hsa041450.77397254
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76008239
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74855001
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69701457
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.68596849
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64156677
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62914439
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62623412
64Type II diabetes mellitus_Homo sapiens_hsa049300.61345902
65Protein export_Homo sapiens_hsa030600.61318855
66* Alcoholism_Homo sapiens_hsa050340.59488307
67Pyruvate metabolism_Homo sapiens_hsa006200.56364399
68Steroid biosynthesis_Homo sapiens_hsa001000.55844346
69MAPK signaling pathway_Homo sapiens_hsa040100.53716434
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53220920
71Vitamin B6 metabolism_Homo sapiens_hsa007500.52058466
72Thyroid hormone synthesis_Homo sapiens_hsa049180.50043464
73Nitrogen metabolism_Homo sapiens_hsa009100.47830068
74Type I diabetes mellitus_Homo sapiens_hsa049400.47169204
75Pancreatic secretion_Homo sapiens_hsa049720.46158260
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44606920
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.43302370
78Choline metabolism in cancer_Homo sapiens_hsa052310.43280068
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.42747844
80* Ras signaling pathway_Homo sapiens_hsa040140.41828593
81Bile secretion_Homo sapiens_hsa049760.41536173
82Regulation of autophagy_Homo sapiens_hsa041400.41343394
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41248304
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40864860
85Dilated cardiomyopathy_Homo sapiens_hsa054140.40826204
86Dorso-ventral axis formation_Homo sapiens_hsa043200.40639362
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40320561
88Proteasome_Homo sapiens_hsa030500.39054150
89Circadian rhythm_Homo sapiens_hsa047100.36106114
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35876597
91Melanoma_Homo sapiens_hsa052180.35806171
92Glucagon signaling pathway_Homo sapiens_hsa049220.35692980
93Endocytosis_Homo sapiens_hsa041440.34909438
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34523050
95Ether lipid metabolism_Homo sapiens_hsa005650.33723905
96Endometrial cancer_Homo sapiens_hsa052130.32781243
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32628764
98Wnt signaling pathway_Homo sapiens_hsa043100.32593009
99Insulin signaling pathway_Homo sapiens_hsa049100.30944034
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30773545
101Renal cell carcinoma_Homo sapiens_hsa052110.30658280
102Rap1 signaling pathway_Homo sapiens_hsa040150.30037892
103VEGF signaling pathway_Homo sapiens_hsa043700.29004152
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.28572874
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27840425
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27403395
107Butanoate metabolism_Homo sapiens_hsa006500.27072903
108Prion diseases_Homo sapiens_hsa050200.26881203
109Ovarian steroidogenesis_Homo sapiens_hsa049130.26623809
110Phenylalanine metabolism_Homo sapiens_hsa003600.26193282
111Hippo signaling pathway_Homo sapiens_hsa043900.25640187
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24958385
113Hedgehog signaling pathway_Homo sapiens_hsa043400.23730192
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23251044
115Colorectal cancer_Homo sapiens_hsa052100.22420744
1162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.21381168
117Inositol phosphate metabolism_Homo sapiens_hsa005620.21195145
118Arginine and proline metabolism_Homo sapiens_hsa003300.20704780
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.18498139

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