GNE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.17247265
2L-phenylalanine catabolic process (GO:0006559)7.17247265
3L-phenylalanine metabolic process (GO:0006558)6.99091208
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.99091208
5aromatic amino acid family catabolic process (GO:0009074)6.38554335
6epoxygenase P450 pathway (GO:0019373)6.16278283
7omega-hydroxylase P450 pathway (GO:0097267)5.93114531
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.81559511
9kynurenine metabolic process (GO:0070189)5.73994204
10indole-containing compound catabolic process (GO:0042436)5.72248362
11indolalkylamine catabolic process (GO:0046218)5.72248362
12tryptophan catabolic process (GO:0006569)5.72248362
13bile acid biosynthetic process (GO:0006699)5.48545891
14sulfur amino acid catabolic process (GO:0000098)5.44641835
15urea metabolic process (GO:0019627)5.43634665
16urea cycle (GO:0000050)5.43634665
17tryptophan metabolic process (GO:0006568)5.42980677
18alpha-linolenic acid metabolic process (GO:0036109)5.42892783
19glyoxylate metabolic process (GO:0046487)5.29665950
20negative regulation of fibrinolysis (GO:0051918)5.26663489
21high-density lipoprotein particle remodeling (GO:0034375)5.22969798
22peptidyl-glutamic acid carboxylation (GO:0017187)5.10813020
23protein carboxylation (GO:0018214)5.10813020
24cysteine metabolic process (GO:0006534)5.06312862
25regulation of protein activation cascade (GO:2000257)5.02391965
26complement activation, alternative pathway (GO:0006957)5.02021719
27regulation of fibrinolysis (GO:0051917)5.01276010
28nitrogen cycle metabolic process (GO:0071941)4.97678555
29bile acid metabolic process (GO:0008206)4.79304622
30fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.76764043
31serine family amino acid catabolic process (GO:0009071)4.71474471
32regulation of complement activation (GO:0030449)4.68379054
33aromatic amino acid family metabolic process (GO:0009072)4.67736826
34regulation of triglyceride catabolic process (GO:0010896)4.67704868
35lysine metabolic process (GO:0006553)4.66433716
36lysine catabolic process (GO:0006554)4.66433716
37homocysteine metabolic process (GO:0050667)4.65592726
38ethanol metabolic process (GO:0006067)4.60563411
39reverse cholesterol transport (GO:0043691)4.58602666
40tyrosine metabolic process (GO:0006570)4.51338553
41protein-lipid complex remodeling (GO:0034368)4.43339347
42macromolecular complex remodeling (GO:0034367)4.43339347
43plasma lipoprotein particle remodeling (GO:0034369)4.43339347
44negative regulation of sterol transport (GO:0032372)4.42009507
45negative regulation of cholesterol transport (GO:0032375)4.42009507
46drug metabolic process (GO:0017144)4.40085150
47acylglycerol homeostasis (GO:0055090)4.38852993
48triglyceride homeostasis (GO:0070328)4.38852993
49amino-acid betaine metabolic process (GO:0006577)4.38336673
50alpha-amino acid catabolic process (GO:1901606)4.38040480
51regulation of cholesterol esterification (GO:0010872)4.34763198
52bile acid and bile salt transport (GO:0015721)4.34000728
53uronic acid metabolic process (GO:0006063)4.30552282
54glucuronate metabolic process (GO:0019585)4.30552282
55oxidative demethylation (GO:0070989)4.27191364
56cellular ketone body metabolic process (GO:0046950)4.25347143
57ethanol oxidation (GO:0006069)4.20910398
58phospholipid efflux (GO:0033700)4.18342357
59cellular amino acid catabolic process (GO:0009063)4.10969377
60coenzyme catabolic process (GO:0009109)4.09530501
61glycine metabolic process (GO:0006544)4.09017466
62indolalkylamine metabolic process (GO:0006586)4.08565848
63cellular modified amino acid catabolic process (GO:0042219)4.08514480
64phenylpropanoid metabolic process (GO:0009698)4.08078747
65plasma lipoprotein particle clearance (GO:0034381)4.04663086
66glutamate metabolic process (GO:0006536)4.01501727
67regulation of cholesterol homeostasis (GO:2000188)3.93489072
68benzene-containing compound metabolic process (GO:0042537)3.91512965
69cholesterol efflux (GO:0033344)3.90445429
70cellular glucuronidation (GO:0052695)3.88292162
71S-adenosylmethionine metabolic process (GO:0046500)3.87454676
72imidazole-containing compound metabolic process (GO:0052803)3.86399485
73serine family amino acid metabolic process (GO:0009069)3.86088175
74drug catabolic process (GO:0042737)3.84918019
75dicarboxylic acid biosynthetic process (GO:0043650)3.79298941
76cellular biogenic amine catabolic process (GO:0042402)3.78746544
77amine catabolic process (GO:0009310)3.78746544
78short-chain fatty acid metabolic process (GO:0046459)3.77747942
79arginine metabolic process (GO:0006525)3.74864268
80intestinal cholesterol absorption (GO:0030299)3.74094571
81plasma lipoprotein particle assembly (GO:0034377)3.71670850
82phospholipid homeostasis (GO:0055091)3.70751922
83ketone body metabolic process (GO:1902224)3.67736731
84behavioral response to nicotine (GO:0035095)3.67479226
85serine family amino acid biosynthetic process (GO:0009070)3.67266785
86negative regulation of protein activation cascade (GO:2000258)3.65460120
87fibrinolysis (GO:0042730)3.64329638
88complement activation, classical pathway (GO:0006958)3.63895707
89positive regulation of triglyceride lipase activity (GO:0061365)3.63251426
90positive regulation of lipoprotein lipase activity (GO:0051006)3.63251426
91negative regulation of lipase activity (GO:0060192)3.62899018
92blood coagulation, intrinsic pathway (GO:0007597)3.62761938
93positive regulation of lipid catabolic process (GO:0050996)3.62606888
94organic acid catabolic process (GO:0016054)3.62157948
95carboxylic acid catabolic process (GO:0046395)3.62157948
96regulation of bile acid biosynthetic process (GO:0070857)3.61356454
972-oxoglutarate metabolic process (GO:0006103)3.60812965
98acetyl-CoA metabolic process (GO:0006084)3.59471108
99cholesterol homeostasis (GO:0042632)3.58010799
100protein activation cascade (GO:0072376)3.54384303
101complement activation (GO:0006956)3.54343639
102nucleobase catabolic process (GO:0046113)3.53701748
103flavonoid metabolic process (GO:0009812)3.52630268
104sterol homeostasis (GO:0055092)3.52589145
105cytolysis (GO:0019835)3.46953426
106low-density lipoprotein particle remodeling (GO:0034374)3.46526971
107positive regulation of fatty acid beta-oxidation (GO:0032000)3.45480291
108epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.44158843
109valine metabolic process (GO:0006573)3.42899424
110drug transmembrane transport (GO:0006855)3.42803519
111fatty acid oxidation (GO:0019395)3.42552407
112cofactor catabolic process (GO:0051187)3.40138868
113exogenous drug catabolic process (GO:0042738)3.39850923
114acute-phase response (GO:0006953)3.39609545
115macroautophagy (GO:0016236)3.38971674
116pyrimidine nucleobase catabolic process (GO:0006208)3.24226975
117alkaloid metabolic process (GO:0009820)3.23950271
118negative regulation of complement activation (GO:0045916)3.23581071
119primary alcohol catabolic process (GO:0034310)3.22131925
120axonemal dynein complex assembly (GO:0070286)3.08413190
121intestinal absorption (GO:0050892)3.05532810
122positive regulation of glycolytic process (GO:0045821)2.98590517
123regulation of hexokinase activity (GO:1903299)2.96260454
124regulation of glucokinase activity (GO:0033131)2.96260454
125cilium or flagellum-dependent cell motility (GO:0001539)2.92134035
126xenobiotic metabolic process (GO:0006805)2.84923987
127primary alcohol metabolic process (GO:0034308)2.79458576
128heme transport (GO:0015886)2.70535648
129L-fucose metabolic process (GO:0042354)2.68860295
130L-fucose catabolic process (GO:0042355)2.68860295
131fucose catabolic process (GO:0019317)2.68860295
132androgen metabolic process (GO:0008209)2.66858232
133nephron epithelium morphogenesis (GO:0072088)2.60174777
134nephron tubule morphogenesis (GO:0072078)2.60174777
135positive regulation of fatty acid oxidation (GO:0046321)2.59967715
136epithelial cilium movement (GO:0003351)2.59281629
137regulation of plasminogen activation (GO:0010755)2.56599840
138opsonization (GO:0008228)2.55375388
139purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.55181778
1403-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.55181778
141peptidyl-glutamic acid modification (GO:0018200)2.54489098
142negative regulation of humoral immune response (GO:0002921)2.53463053
143positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.52216024
144sodium-independent organic anion transport (GO:0043252)2.51131048

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.88018203
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.86703193
3* LXR_22158963_ChIP-Seq_LIVER_Mouse6.07814151
4EGR1_23403033_ChIP-Seq_LIVER_Mouse6.04651782
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.13057678
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.80213397
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.61300846
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.87876765
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.52352385
10ZNF274_21170338_ChIP-Seq_K562_Hela2.49417212
11GBX2_23144817_ChIP-Seq_PC3_Human2.47560236
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27712114
13GATA1_22025678_ChIP-Seq_K562_Human2.25450430
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.21316279
15PIAS1_25552417_ChIP-Seq_VCAP_Human2.19272834
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.14810407
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12584405
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11730703
19* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09232918
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04559772
21TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.03726095
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.2459014
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.96908444
24CLOCK_20551151_ChIP-Seq_293T_Human1.94153603
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.92124908
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88075461
27FOXA2_19822575_ChIP-Seq_HepG2_Human1.76796438
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73302744
29FUS_26573619_Chip-Seq_HEK293_Human1.70096712
30VDR_22108803_ChIP-Seq_LS180_Human1.67237476
31* STAT3_23295773_ChIP-Seq_U87_Human1.67202734
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.63961168
33SMAD4_21799915_ChIP-Seq_A2780_Human1.61803314
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60886363
35TAF15_26573619_Chip-Seq_HEK293_Human1.60385735
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.56350444
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56165210
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.55880476
39BCAT_22108803_ChIP-Seq_LS180_Human1.49513854
40* TCF4_23295773_ChIP-Seq_U87_Human1.49005268
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48959949
42NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48852777
43ER_23166858_ChIP-Seq_MCF-7_Human1.48453835
44* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.47329421
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46527338
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45521594
47AR_25329375_ChIP-Seq_VCAP_Human1.44394847
48HNF4A_19822575_ChIP-Seq_HepG2_Human1.44073190
49P300_19829295_ChIP-Seq_ESCs_Human1.36755431
50* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.36638353
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.34683669
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34420259
53* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34309952
54ZNF263_19887448_ChIP-Seq_K562_Human1.34100967
55TP53_16413492_ChIP-PET_HCT116_Human1.32314607
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27787112
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25788188
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.25463906
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24694604
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23676151
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23293482
62CJUN_26792858_Chip-Seq_BT549_Human1.23227752
63* CDX2_22108803_ChIP-Seq_LS180_Human1.22944841
64AHR_22903824_ChIP-Seq_MCF-7_Human1.22569064
65NANOG_18555785_Chip-Seq_ESCs_Mouse1.22519659
66CBP_20019798_ChIP-Seq_JUKART_Human1.20515573
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20515573
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.20026660
69ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19406006
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17493177
71REST_21632747_ChIP-Seq_MESCs_Mouse1.17387166
72EWS_26573619_Chip-Seq_HEK293_Human1.17141547
73* CBX2_27304074_Chip-Seq_ESCs_Mouse1.16834020
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16797527
75AR_21572438_ChIP-Seq_LNCaP_Human1.16637260
76ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16431353
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16139815
78DROSHA_22980978_ChIP-Seq_HELA_Human1.15407110
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15394313
80GATA4_25053715_ChIP-Seq_YYC3_Human1.15343660
81IGF1R_20145208_ChIP-Seq_DFB_Human1.15120808
82IRF8_22096565_ChIP-ChIP_GC-B_Human1.14926330
83HTT_18923047_ChIP-ChIP_STHdh_Human1.14514085
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13402715
85ESR2_21235772_ChIP-Seq_MCF-7_Human1.13199359
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12480267
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11637561
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09734429
89KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09579023
90RUNX2_22187159_ChIP-Seq_PCA_Human1.09169140
91EZH2_27294783_Chip-Seq_NPCs_Mouse1.09091039
92TCF4_18268006_ChIP-ChIP_LS174T_Human1.09056414
93SMAD4_21741376_ChIP-Seq_EPCs_Human1.07948253
94FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07802073
95* TCF4_22108803_ChIP-Seq_LS180_Human1.07723435
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07273052
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07273052
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05350769
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04964376
100P53_22387025_ChIP-Seq_ESCs_Mouse1.04368329
101RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04126131
102TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03791428
103RXRA_24833708_ChIP-Seq_LIVER_Mouse1.03377971
104NFE2_27457419_Chip-Seq_LIVER_Mouse1.03128772
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01749314
106SOX2_21211035_ChIP-Seq_LN229_Gbm1.00979750
107SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00499922
108CDX2_20551321_ChIP-Seq_CACO-2_Human1.00470603
109BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99753226
110NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98549972
111ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97663579
112AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.93740164
113IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93540204
114LXR_22292898_ChIP-Seq_THP-1_Human0.93319334
115GATA6_25053715_ChIP-Seq_YYC3_Human0.90598081
116ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87857266
117ESR1_21235772_ChIP-Seq_MCF-7_Human0.85964916
118FOXO3_23340844_ChIP-Seq_DLD1_Human0.82897058
119CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80869470
120TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.80157802
121SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.79310177
122BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77348344
123RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.75896188
124FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.75541161
125RARA_24833708_ChIP-Seq_LIVER_Mouse0.75125604
126GATA1_19941827_ChIP-Seq_MEL_Mouse0.75044409
127PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.74402613
128ESR1_20079471_ChIP-ChIP_T-47D_Human0.74085711
129RACK7_27058665_Chip-Seq_MCF-7_Human0.73876919
130GATA1_19941826_ChIP-Seq_K562_Human0.73511065
131NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.73288166
132GATA2_19941826_ChIP-Seq_K562_Human0.72409154
133* SOX2_20726797_ChIP-Seq_SW620_Human0.71368374
134FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.70853998
135* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.70594391
136ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.69572065
137STAT3_1855785_ChIP-Seq_MESCs_Mouse0.67744377
138SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67626369
139FOXA1_25552417_ChIP-Seq_VCAP_Human0.67288495
140RARB_24833708_ChIP-Seq_LIVER_Mouse0.66724460
141BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66331407
142PPAR_26484153_Chip-Seq_NCI-H1993_Human0.64320037
143KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.62596086
144FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.62180874
145NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.61860254
146BRD4_27068464_Chip-Seq_AML-cells_Mouse0.61134437
147AUTS2_25519132_ChIP-Seq_293T-REX_Human0.60844250
148E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.60092508
149Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.59918618
150GATA3_24758297_ChIP-Seq_MCF-7_Human0.57850230
151TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.56921664
152RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.56381670
153PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.55400731
154GATA2_21666600_ChIP-Seq_HMVEC_Human0.55338263
155GATA1_22383799_ChIP-Seq_G1ME_Mouse0.54854136
156GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.54609855
157TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.54200049
158CEBPB_22108803_ChIP-Seq_LS180_Human0.53839193
159ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.53427752
160EGR1_19032775_ChIP-ChIP_M12_Human0.52743506
161NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.51982651
162RAD21_21589869_ChIP-Seq_MESCs_Mouse0.51936323
163TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.51723886
164CREB1_26743006_Chip-Seq_LNCaP_Human0.50288743
165MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.49511799
166MYC_19915707_ChIP-ChIP_AK7_Human0.48615874
167ATF3_27146783_Chip-Seq_COLON_Human0.48584645
168SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.47729966
169TBX20_22328084_ChIP-Seq_HEART_Mouse0.47648892
170TBX20_22080862_ChIP-Seq_HEART_Mouse0.47648892
171* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.47512051
172NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.47235985
173NRF2_20460467_ChIP-Seq_MEFs_Mouse0.47235985
174P53_21459846_ChIP-Seq_SAOS-2_Human0.47233997
175AR_20517297_ChIP-Seq_VCAP_Human0.47192855
176TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.46297133

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.81945527
2MP0005360_urolithiasis7.05775646
3MP0005085_abnormal_gallbladder_physiolo6.15383091
4MP0005365_abnormal_bile_salt5.97727734
5MP0008875_abnormal_xenobiotic_pharmacok4.95716740
6MP0003806_abnormal_nucleotide_metabolis3.83539083
7MP0003252_abnormal_bile_duct3.82254195
8MP0010329_abnormal_lipoprotein_level3.49599905
9MP0009840_abnormal_foam_cell3.14839988
10MP0005083_abnormal_biliary_tract2.95200867
11MP0001666_abnormal_nutrient_absorption2.92158455
12MP0005332_abnormal_amino_acid2.55827479
13MP0003191_abnormal_cellular_cholesterol2.40191407
14MP0003195_calcinosis2.39356716
15MP0000609_abnormal_liver_physiology2.19023766
16MP0003868_abnormal_feces_composition2.18392102
17MP0002118_abnormal_lipid_homeostasis2.06674577
18MP0002138_abnormal_hepatobiliary_system1.97599470
19MP0004019_abnormal_vitamin_homeostasis1.97175173
20MP0002909_abnormal_adrenal_gland1.88840507
21* MP0005319_abnormal_enzyme/_coenzyme1.81325357
22MP0002638_abnormal_pupillary_reflex1.62223396
23MP0005584_abnormal_enzyme/coenzyme_acti1.56583346
24MP0001764_abnormal_homeostasis1.55961444
25MP0005645_abnormal_hypothalamus_physiol1.51931947
26MP0000013_abnormal_adipose_tissue1.49306921
27MP0010234_abnormal_vibrissa_follicle1.41919750
28* MP0009643_abnormal_urine_homeostasis1.40490484
29MP0002102_abnormal_ear_morphology1.39364328
30MP0009046_muscle_twitch1.38476971
31MP0003656_abnormal_erythrocyte_physiolo1.38165419
32MP0003705_abnormal_hypodermis_morpholog1.37001614
33MP0005551_abnormal_eye_electrophysiolog1.34247616
34MP0003283_abnormal_digestive_organ1.31145821
35MP0009697_abnormal_copulation1.28561923
36MP0004147_increased_porphyrin_level1.28377623
37MP0010386_abnormal_urinary_bladder1.27207695
38MP0003890_abnormal_embryonic-extraembry1.25198826
39MP0000598_abnormal_liver_morphology1.23085136
40MP0001501_abnormal_sleep_pattern1.23035503
41MP0000569_abnormal_digit_pigmentation1.20981223
42MP0005379_endocrine/exocrine_gland_phen1.16624819
43MP0000604_amyloidosis1.13400168
44MP0009745_abnormal_behavioral_response1.13194310
45MP0003186_abnormal_redox_activity1.11451175
46MP0010368_abnormal_lymphatic_system1.10839644
47MP0005636_abnormal_mineral_homeostasis1.09513467
48MP0003011_delayed_dark_adaptation1.08190042
49MP0000003_abnormal_adipose_tissue1.06485766
50MP0005220_abnormal_exocrine_pancreas1.05928584
51MP0001502_abnormal_circadian_rhythm1.04465037
52MP0000427_abnormal_hair_cycle1.03492299
53MP0009764_decreased_sensitivity_to1.03124584
54MP0005647_abnormal_sex_gland1.02975943
55MP0004264_abnormal_extraembryonic_tissu1.02041430
56MP0004142_abnormal_muscle_tone0.99573555
57MP0005670_abnormal_white_adipose0.98417813
58MP0003122_maternal_imprinting0.96378852
59MP0009763_increased_sensitivity_to0.96295615
60MP0005451_abnormal_body_composition0.96238491
61MP0003300_gastrointestinal_ulcer0.95764667
62MP0004924_abnormal_behavior0.94841611
63MP0005386_behavior/neurological_phenoty0.94841611
64MP0004130_abnormal_muscle_cell0.94287769
65* MP0009642_abnormal_blood_homeostasis0.90050313
66MP0002168_other_aberrant_phenotype0.88779967
67* MP0008469_abnormal_protein_level0.88708432
68MP0006036_abnormal_mitochondrial_physio0.86353610
69MP0002078_abnormal_glucose_homeostasis0.86201098
70MP0002693_abnormal_pancreas_physiology0.85958420
71MP0004133_heterotaxia0.85857180
72MP0002163_abnormal_gland_morphology0.84170573
73MP0003632_abnormal_nervous_system0.83973444
74MP0002272_abnormal_nervous_system0.83727314
75MP0002557_abnormal_social/conspecific_i0.83684651
76MP0005408_hypopigmentation0.82901120
77MP0000383_abnormal_hair_follicle0.82041719
78MP0000631_abnormal_neuroendocrine_gland0.80868584
79MP0002254_reproductive_system_inflammat0.80758166
80MP0002064_seizures0.78243564
81MP0000566_synostosis0.77916930
82MP0009765_abnormal_xenobiotic_induced0.77382273
83MP0004885_abnormal_endolymph0.75487022
84MP0001756_abnormal_urination0.75242469
85MP0008775_abnormal_heart_ventricle0.74985210
86MP0005084_abnormal_gallbladder_morpholo0.74837494
87MP0005376_homeostasis/metabolism_phenot0.74825577
88MP0002572_abnormal_emotion/affect_behav0.74754116
89MP0002876_abnormal_thyroid_physiology0.74479539
90MP0005464_abnormal_platelet_physiology0.74296763
91MP0003879_abnormal_hair_cell0.73617492
92MP0003950_abnormal_plasma_membrane0.73606894
93MP0005334_abnormal_fat_pad0.72840541
94MP0002938_white_spotting0.72823638
95MP0005253_abnormal_eye_physiology0.72810951
96MP0005409_darkened_coat_color0.71367109
97MP0010678_abnormal_skin_adnexa0.70366258
98MP0005395_other_phenotype0.68407714
99MP0002009_preneoplasia0.65872979
100MP0002971_abnormal_brown_adipose0.65501482
101MP0005646_abnormal_pituitary_gland0.64409123
102MP0006072_abnormal_retinal_apoptosis0.64190790
103MP0003045_fibrosis0.62832441
104MP0005666_abnormal_adipose_tissue0.61716559
105MP0001986_abnormal_taste_sensitivity0.61637620
106MP0003329_amyloid_beta_deposits0.61016981
107MP0001440_abnormal_grooming_behavior0.60707687
108MP0000778_abnormal_nervous_system0.60427658
109MP0003646_muscle_fatigue0.60379406
110MP0002837_dystrophic_cardiac_calcinosis0.60019999
111MP0005535_abnormal_body_temperature0.59668969
112MP0005266_abnormal_metabolism0.58753595
113MP0002063_abnormal_learning/memory/cond0.58736606
114MP0003633_abnormal_nervous_system0.58512840
115MP0001970_abnormal_pain_threshold0.57703841
116MP0002733_abnormal_thermal_nociception0.57349506
117MP0006276_abnormal_autonomic_nervous0.56380534
118MP0001881_abnormal_mammary_gland0.55220826
119MP0001765_abnormal_ion_homeostasis0.54538852
120MP0005448_abnormal_energy_balance0.54380175
121MP0001873_stomach_inflammation0.54215099
122MP0000639_abnormal_adrenal_gland0.53691713
123* MP0002136_abnormal_kidney_physiology0.52847466
124MP0001661_extended_life_span0.52677835
125MP0008873_increased_physiological_sensi0.50479234
126MP0003075_altered_response_to0.49757196
127MP0009384_cardiac_valve_regurgitation0.49404527
128MP0005166_decreased_susceptibility_to0.48555527
129MP0003953_abnormal_hormone_level0.47541597
130MP0008874_decreased_physiological_sensi0.47082017
131MP0009780_abnormal_chondrocyte_physiolo0.47072192
132MP0005167_abnormal_blood-brain_barrier0.46953079
133MP0003638_abnormal_response/metabolism_0.46609881
134MP0002928_abnormal_bile_duct0.45700550
135MP0004782_abnormal_surfactant_physiolog0.45698460
136MP0001944_abnormal_pancreas_morphology0.45230112
137MP0001663_abnormal_digestive_system0.45190939
138MP0010155_abnormal_intestine_physiology0.45045803
139MP0000230_abnormal_systemic_arterial0.44672526
140MP0006035_abnormal_mitochondrial_morpho0.43802464
141MP0002166_altered_tumor_susceptibility0.43772494
142MP0001845_abnormal_inflammatory_respons0.42471777
143MP0003436_decreased_susceptibility_to0.42159715
144MP0003690_abnormal_glial_cell0.41606513
145MP0003724_increased_susceptibility_to0.41159278
146MP0000249_abnormal_blood_vessel0.40685047
147MP0005058_abnormal_lysosome_morphology0.40461129
148MP0008872_abnormal_physiological_respon0.40286097
149MP0004947_skin_inflammation0.40147957
150MP0002822_catalepsy0.39255897
151MP0004043_abnormal_pH_regulation0.37368272
152MP0005187_abnormal_penis_morphology0.36897054
153MP0005381_digestive/alimentary_phenotyp0.36856750
154MP0009053_abnormal_anal_canal0.36244250
155MP0009115_abnormal_fat_cell0.34830797
156MP0002970_abnormal_white_adipose0.33942000

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.09701196
2Deep venous thrombosis (HP:0002625)6.99622006
3Intrahepatic cholestasis (HP:0001406)6.91737873
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.41117094
5Prolonged partial thromboplastin time (HP:0003645)5.98763135
6Xanthomatosis (HP:0000991)5.89491964
7Hypobetalipoproteinemia (HP:0003563)5.81941704
8Hyperlipoproteinemia (HP:0010980)5.02896709
9Complement deficiency (HP:0004431)4.95675421
10Hyperammonemia (HP:0001987)4.52305581
11Abnormality of the common coagulation pathway (HP:0010990)4.47037292
12Hypolipoproteinemia (HP:0010981)4.38435838
13Ketosis (HP:0001946)4.32858584
14Fat malabsorption (HP:0002630)4.20375971
15Joint hemorrhage (HP:0005261)4.20323903
16Epidermoid cyst (HP:0200040)4.12630227
17Hyperglycinemia (HP:0002154)4.09882626
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.99496375
19Abnormality of glutamine family amino acid metabolism (HP:0010902)3.99418741
20Abnormality of the intrinsic pathway (HP:0010989)3.94005730
21Abnormality of sulfur amino acid metabolism (HP:0004339)3.93916327
22Hypoglycemic coma (HP:0001325)3.88966082
23Hypoalphalipoproteinemia (HP:0003233)3.87655428
24Abnormality of methionine metabolism (HP:0010901)3.75529056
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.70828252
26Hyperventilation (HP:0002883)3.70275560
27Conjugated hyperbilirubinemia (HP:0002908)3.61798465
28Abnormality of glycine metabolism (HP:0010895)3.60459159
29Abnormality of serine family amino acid metabolism (HP:0010894)3.60459159
30Hyperglycinuria (HP:0003108)3.59665217
31Abnormality of complement system (HP:0005339)3.59602514
32Decreased circulating renin level (HP:0003351)3.49153356
33Fair hair (HP:0002286)3.43212908
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.42739313
35Hypercholesterolemia (HP:0003124)3.30612515
36Hyperbilirubinemia (HP:0002904)3.29984055
37Abnormality of pyrimidine metabolism (HP:0004353)3.29459818
38Abnormal respiratory epithelium morphology (HP:0012253)3.28510175
39Abnormal respiratory motile cilium morphology (HP:0005938)3.28510175
40Abnormality of fatty-acid metabolism (HP:0004359)3.26892972
41Ketoacidosis (HP:0001993)3.24210087
42Steatorrhea (HP:0002570)3.21316537
43Dynein arm defect of respiratory motile cilia (HP:0012255)3.12693764
44Absent/shortened dynein arms (HP:0200106)3.12693764
45Spontaneous abortion (HP:0005268)3.06296056
46Delayed CNS myelination (HP:0002188)3.00202340
47Hepatocellular carcinoma (HP:0001402)2.90828420
48Tubular atrophy (HP:0000092)2.90651872
49Nephronophthisis (HP:0000090)2.90212747
50Abnormality of nucleobase metabolism (HP:0010932)2.89963135
51Pancreatic cysts (HP:0001737)2.88840461
52Myocardial infarction (HP:0001658)2.84186855
53Pancreatic fibrosis (HP:0100732)2.83256740
54Abnormality of midbrain morphology (HP:0002418)2.80191374
55Molar tooth sign on MRI (HP:0002419)2.80191374
56Chronic hepatic failure (HP:0100626)2.76043020
57Skin nodule (HP:0200036)2.75815050
58Abnormality of serum amino acid levels (HP:0003112)2.75629209
59Arthropathy (HP:0003040)2.73876012
60Abnormality of renin-angiotensin system (HP:0000847)2.73347841
61Metabolic acidosis (HP:0001942)2.71423191
62Abnormality of purine metabolism (HP:0004352)2.70214794
63Acanthocytosis (HP:0001927)2.65069148
64Generalized hypopigmentation of hair (HP:0011358)2.63945607
65Abnormal ciliary motility (HP:0012262)2.63161258
66Abnormality of the renal cortex (HP:0011035)2.62101500
67Hypothermia (HP:0002045)2.58186952
68Spastic diplegia (HP:0001264)2.56036345
69Abnormality of the renal medulla (HP:0100957)2.55197407
70Hyperactive renin-angiotensin system (HP:0000841)2.52863175
71Abnormality of dicarboxylic acid metabolism (HP:0010995)2.52251600
72Dicarboxylic aciduria (HP:0003215)2.52251600
73Hypoglycemic seizures (HP:0002173)2.51560872
74Abnormality of alanine metabolism (HP:0010916)2.49454201
75Hyperalaninemia (HP:0003348)2.49454201
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.49454201
77Congenital stationary night blindness (HP:0007642)2.49282841
78Gout (HP:0001997)2.48763454
79Rhinitis (HP:0012384)2.48078885
80Abnormal respiratory motile cilium physiology (HP:0012261)2.43654847
81Vascular calcification (HP:0004934)2.42532051
82Type II lissencephaly (HP:0007260)2.41477041
83Hypochromic microcytic anemia (HP:0004840)2.39327281
84Lethargy (HP:0001254)2.39043178
85Metabolic alkalosis (HP:0200114)2.38074407
86Abnormal gallbladder morphology (HP:0012437)2.36552242
87Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.35339199
88Large for gestational age (HP:0001520)2.35317608
89True hermaphroditism (HP:0010459)2.34192333
90Abnormal gallbladder physiology (HP:0012438)2.33877333
91Cholecystitis (HP:0001082)2.33877333
92Late onset (HP:0003584)2.33791488
93Esophageal varix (HP:0002040)2.33771263
94Pancreatitis (HP:0001733)2.33513804
95Cholelithiasis (HP:0001081)2.33092041
96Malnutrition (HP:0004395)2.31623733
97Blue irides (HP:0000635)2.29678782
98Mitral stenosis (HP:0001718)2.29146829
99Gingival bleeding (HP:0000225)2.29113322
100Irritability (HP:0000737)2.28544663
101Abnormality of chloride homeostasis (HP:0011422)2.27761796
102Neonatal onset (HP:0003623)2.27735973
103Menorrhagia (HP:0000132)2.24709132
104Systemic lupus erythematosus (HP:0002725)2.23882208
105Abnormal drinking behavior (HP:0030082)2.18374055
106Polydipsia (HP:0001959)2.18374055
107Cardiovascular calcification (HP:0011915)2.17096140
108Abnormality of vitamin metabolism (HP:0100508)2.14440530
109Brushfield spots (HP:0001088)2.14329709
110Amyloidosis (HP:0011034)2.13777490
111Sensorimotor neuropathy (HP:0007141)2.13716272
112Hemorrhage of the eye (HP:0011885)2.13653590
113Generalized aminoaciduria (HP:0002909)2.13166381
114Glomerulonephritis (HP:0000099)2.11493983
115Cystic liver disease (HP:0006706)2.10184247
116Hyperinsulinemic hypoglycemia (HP:0000825)2.10043944
117Chorioretinal atrophy (HP:0000533)2.08906497
118Nephritis (HP:0000123)2.07157037
119Cerebral edema (HP:0002181)2.06852170
120Thrombophlebitis (HP:0004418)2.06524966
121Broad-based gait (HP:0002136)2.04015379
122Poikilocytosis (HP:0004447)2.02820692
123Bile duct proliferation (HP:0001408)2.02069687
124Abnormal biliary tract physiology (HP:0012439)2.02069687
125Abnormal cartilage morphology (HP:0002763)2.01899157
126Hyperaldosteronism (HP:0000859)1.99892102
127Alkalosis (HP:0001948)1.96887704
128Abnormality of the gallbladder (HP:0005264)1.96030054
129Abnormality of potassium homeostasis (HP:0011042)1.94805492
130Abnormality of transition element cation homeostasis (HP:0011030)1.93877184
131Vomiting (HP:0002013)1.92831019
132Hypokalemia (HP:0002900)1.91091755
133Recurrent gram-negative bacterial infections (HP:0005420)1.89504427
134Widely spaced teeth (HP:0000687)1.89211850
135EEG with generalized epileptiform discharges (HP:0011198)1.89197292
136Hyperkalemia (HP:0002153)1.89158836
137Death in childhood (HP:0003819)1.88513767
138Abnormality of proline metabolism (HP:0010907)1.86507911
139Hydroxyprolinuria (HP:0003080)1.86507911
140Abnormality of iron homeostasis (HP:0011031)1.85710515
141Elevated hepatic transaminases (HP:0002910)1.85119142
142Abnormal enzyme/coenzyme activity (HP:0012379)1.84581479
143Epileptiform EEG discharges (HP:0011182)1.82895807
144Symptomatic seizures (HP:0011145)1.82818306
145Tubulointerstitial fibrosis (HP:0005576)1.82377889
146Furrowed tongue (HP:0000221)1.82066247
147Hypsarrhythmia (HP:0002521)1.80882489
148Hyperglycemia (HP:0003074)1.80795935
149Increased mean platelet volume (HP:0011877)1.78925785
150Pheochromocytoma (HP:0002666)1.76376976
151Opisthotonus (HP:0002179)1.76299377
152Lissencephaly (HP:0001339)1.75413280
153Abnormality of the vitreous humor (HP:0004327)1.75164826
154Enlarged kidneys (HP:0000105)1.74818879
155Rickets (HP:0002748)1.74657224
156Medial flaring of the eyebrow (HP:0010747)1.74605063
157Stroke (HP:0001297)1.74442352
158Inability to walk (HP:0002540)1.72307553
159Abnormal pancreas size (HP:0012094)1.71727164
160Tubulointerstitial abnormality (HP:0001969)1.71454175
161Reticulocytosis (HP:0001923)1.69415945

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.70461276
2ERN15.07721775
3SIK14.13132204
4FGFR43.44597463
5ACVR1B3.36069154
6TAOK33.26567715
7PKN23.20543712
8TRIB33.10457438
9WNK42.93686220
10CASK2.75044227
11INSRR2.65811934
12CAMKK22.56466993
13FLT32.53804161
14FRK2.49417369
15PNCK2.20744491
16ADRBK22.19356614
17BMPR1B2.16366513
18PTK62.05735603
19MST1R1.76306070
20MAP3K41.76124606
21MAP2K41.74226126
22ERBB41.68523950
23PIK3CG1.67739409
24WNK31.67224099
25KDR1.64020934
26PHKG21.63540181
27PHKG11.63540181
28MAPK111.58882303
29TLK11.56432101
30CAMK1G1.55139403
31TYK21.54677939
32MAP3K101.54347173
33LMTK21.48488125
34LATS11.42447848
35NTRK31.40164298
36AKT31.37592859
37MARK11.35237130
38MAP3K71.35201272
39RIPK11.33059945
40GRK61.28101376
41PINK11.25140136
42TRPM71.22326843
43EPHA21.22252583
44TBK11.21012292
45TIE11.19594288
46BRSK21.14504076
47JAK21.14117603
48MAP2K31.14092677
49STK38L1.11838121
50MKNK21.10621778
51EEF2K1.08499374
52NEK91.06602034
53NLK1.06128944
54JAK11.02437905
55ZAK1.01835920
56DAPK21.01151226
57IRAK10.99652185
58SCYL20.99321758
59PRKAA20.98580871
60TGFBR20.94982263
61ERBB30.94948800
62PIK3CA0.94893012
63STK30.94485995
64LRRK20.90384569
65MAP4K20.90074114
66RET0.89592840
67MAPK130.88860111
68EPHB10.86540359
69MAP4K10.86486011
70ERBB20.84789070
71FER0.84450385
72EPHA30.81117506
73STK390.80555932
74MYLK0.79891956
75SIK20.77033714
76PTK20.76851541
77CDK60.76114579
78SGK20.75778142
79WNK10.75240660
80CSF1R0.73956484
81ADRBK10.73902361
82MAP3K110.73086832
83PRKCE0.72376477
84MET0.72045388
85MAP2K60.70761689
86MAP3K20.69048027
87CAMK1D0.68589757
88MAPK40.67649634
89PTK2B0.66556493
90ABL20.65318445
91IKBKE0.64570157
92SGK2230.63859309
93SGK4940.63859309
94MAP2K20.63300032
95MAP2K10.62411996
96PRKG20.62226373
97PRKAA10.62127921
98CAMK40.61974415
99PRKCG0.61627288
100MAP3K10.61292427
101PDPK10.59994813
102PDGFRB0.59072985
103MAP2K70.57107370
104MAP3K30.56558935
105MAPKAPK30.56542042
106STK380.55985208
107JAK30.54529528
108CSK0.53371069
109PRKACG0.52466596
110MAPKAPK50.52192283
111KSR20.51859784
112ZAP700.51838000
113HIPK20.51553067
114MELK0.51444301
115BCR0.51375825
116PDK10.50158687
117STK110.49980098
118PRKCZ0.49813785
119MAPK120.47824759
120TGFBR10.47223530
121MAP3K60.46347405
122TNIK0.46305236
123GSK3A0.45630660
124ICK0.45247505
125KIT0.44985089
126FGFR30.44811186
127SGK30.44541573
128DYRK1B0.44172323
129CAMK2A0.43674432
130CAMKK10.43656653
131FGFR20.43559944
132RPS6KA50.43221391
133PDGFRA0.42467698
134STK240.41651485
135TAOK10.41596550
136NUAK10.41094750
137CSNK1G10.40669438
138SGK10.40409207
139MKNK10.39715294
140CSNK1E0.39497628
141MAP3K90.39425627
142CAMK2G0.36925778
143MTOR0.36504723
144MAP3K50.35754780
145TNK20.35175855
146OXSR10.34286752
147IGF1R0.34223425
148CAMK2D0.33636490
149EGFR0.32820967
150PRKCQ0.32289606
151PRKD10.29426752
152MAPK150.28265190
153ITK0.26662814
154CDK40.25278844
155GRK10.25275373
156PAK30.24917733
157BTK0.24531095
158PAK20.24192991
159MAP3K130.22740206

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.37649516
2Nitrogen metabolism_Homo sapiens_hsa009103.65914874
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.39553351
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.36248213
5Arginine biosynthesis_Homo sapiens_hsa002203.08770055
6Tryptophan metabolism_Homo sapiens_hsa003802.73966061
7Fatty acid degradation_Homo sapiens_hsa000712.62387443
8Complement and coagulation cascades_Homo sapiens_hsa046102.61062078
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.60692094
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.53501769
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.48750465
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.35755243
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22193476
14Butanoate metabolism_Homo sapiens_hsa006502.07451368
15Caffeine metabolism_Homo sapiens_hsa002322.03787936
16Propanoate metabolism_Homo sapiens_hsa006401.99773854
17Peroxisome_Homo sapiens_hsa041461.98441224
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.94809367
19PPAR signaling pathway_Homo sapiens_hsa033201.87296512
20Fatty acid metabolism_Homo sapiens_hsa012121.83033757
21Histidine metabolism_Homo sapiens_hsa003401.81964866
22Sulfur metabolism_Homo sapiens_hsa009201.79633977
23Chemical carcinogenesis_Homo sapiens_hsa052041.76364994
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.72602806
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.70042185
26Selenocompound metabolism_Homo sapiens_hsa004501.69622587
27beta-Alanine metabolism_Homo sapiens_hsa004101.67305132
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.67295437
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.66970043
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.66519150
31Bile secretion_Homo sapiens_hsa049761.62971882
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.51909776
33Staphylococcus aureus infection_Homo sapiens_hsa051501.47815110
34Phenylalanine metabolism_Homo sapiens_hsa003601.45558832
35Retinol metabolism_Homo sapiens_hsa008301.44831549
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41722151
37Pyruvate metabolism_Homo sapiens_hsa006201.41657643
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34683354
39Folate biosynthesis_Homo sapiens_hsa007901.34160577
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.31529515
41Starch and sucrose metabolism_Homo sapiens_hsa005001.31412053
42Tyrosine metabolism_Homo sapiens_hsa003501.29966207
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.27931332
44ABC transporters_Homo sapiens_hsa020101.26678391
45Biosynthesis of amino acids_Homo sapiens_hsa012301.25167528
46Fat digestion and absorption_Homo sapiens_hsa049751.22971941
47Carbon metabolism_Homo sapiens_hsa012001.20182723
48Fatty acid elongation_Homo sapiens_hsa000621.08602939
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05186660
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.04021743
51Arachidonic acid metabolism_Homo sapiens_hsa005900.99576137
52Sulfur relay system_Homo sapiens_hsa041220.96975050
53Arginine and proline metabolism_Homo sapiens_hsa003300.91487957
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88047268
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87767724
56Insulin secretion_Homo sapiens_hsa049110.87506193
57Lysine degradation_Homo sapiens_hsa003100.85560626
58Steroid biosynthesis_Homo sapiens_hsa001000.83320590
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79197048
60Vitamin digestion and absorption_Homo sapiens_hsa049770.77782404
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77504735
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76945200
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76926340
64Circadian rhythm_Homo sapiens_hsa047100.72002445
65Glycerolipid metabolism_Homo sapiens_hsa005610.71527743
66One carbon pool by folate_Homo sapiens_hsa006700.67082736
67Mineral absorption_Homo sapiens_hsa049780.65927033
68Ether lipid metabolism_Homo sapiens_hsa005650.65621516
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64458632
70Pentose phosphate pathway_Homo sapiens_hsa000300.63190010
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62553576
72Serotonergic synapse_Homo sapiens_hsa047260.56821297
73Glutathione metabolism_Homo sapiens_hsa004800.56695337
74Vitamin B6 metabolism_Homo sapiens_hsa007500.55437591
75Fatty acid biosynthesis_Homo sapiens_hsa000610.54934815
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49651314
77Cocaine addiction_Homo sapiens_hsa050300.46232023
78Galactose metabolism_Homo sapiens_hsa000520.45712042
79Nicotine addiction_Homo sapiens_hsa050330.44292314
80Insulin resistance_Homo sapiens_hsa049310.42574107
81* Metabolic pathways_Homo sapiens_hsa011000.42155652
82Fructose and mannose metabolism_Homo sapiens_hsa000510.42115557
83Type II diabetes mellitus_Homo sapiens_hsa049300.37180905
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36422826
85Dorso-ventral axis formation_Homo sapiens_hsa043200.35704812
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34316449
87Phototransduction_Homo sapiens_hsa047440.34127857
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.30566089
89Pancreatic secretion_Homo sapiens_hsa049720.29764055
90Glutamatergic synapse_Homo sapiens_hsa047240.28271894
91Prion diseases_Homo sapiens_hsa050200.26437190
92Regulation of autophagy_Homo sapiens_hsa041400.24930072
93Sphingolipid metabolism_Homo sapiens_hsa006000.22450997
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21027216
95GABAergic synapse_Homo sapiens_hsa047270.20989533
96Amphetamine addiction_Homo sapiens_hsa050310.20649129
97Glucagon signaling pathway_Homo sapiens_hsa049220.20580138
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.19312811
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.18642559
100Dopaminergic synapse_Homo sapiens_hsa047280.18564673
101Taste transduction_Homo sapiens_hsa047420.17096185
102AMPK signaling pathway_Homo sapiens_hsa041520.16634666
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15665256
104Renin secretion_Homo sapiens_hsa049240.15610455
105Long-term depression_Homo sapiens_hsa047300.15081664
106Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.14739652
107Salivary secretion_Homo sapiens_hsa049700.14411899
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11990289
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.09539077
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.08498863
111Renin-angiotensin system_Homo sapiens_hsa046140.06388898
112Thyroid hormone synthesis_Homo sapiens_hsa049180.04383140
113* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.03477130
114Insulin signaling pathway_Homo sapiens_hsa049100.03167944
115Linoleic acid metabolism_Homo sapiens_hsa005910.02489628
116Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1657839
117Thyroid cancer_Homo sapiens_hsa05216-0.1536485
118Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1532212
119Amoebiasis_Homo sapiens_hsa05146-0.1393605
120Protein digestion and absorption_Homo sapiens_hsa04974-0.1382941
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1283521
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1239858
123Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.1097864
124Bladder cancer_Homo sapiens_hsa05219-0.0892638
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.0814801
126Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0780922
127Hepatitis C_Homo sapiens_hsa05160-0.0518233
128N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0231580
129Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0230846
130Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0147315

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