GNB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.42954211
2central nervous system myelination (GO:0022010)6.42954211
3myelination (GO:0042552)5.48735177
4axon ensheathment (GO:0008366)5.46229889
5ensheathment of neurons (GO:0007272)5.46229889
6negative regulation of neurotransmitter secretion (GO:0046929)4.99667936
7fatty acid elongation (GO:0030497)4.79009898
8long-chain fatty acid biosynthetic process (GO:0042759)4.70119920
9detection of molecule of bacterial origin (GO:0032490)4.49603052
10presynaptic membrane assembly (GO:0097105)4.32139778
11negative regulation of neurotransmitter transport (GO:0051589)4.23331638
12negative regulation of interleukin-12 production (GO:0032695)4.14349523
13negative regulation of peptidyl-threonine phosphorylation (GO:0010801)4.04137954
14cholesterol biosynthetic process (GO:0006695)4.02383215
15virion attachment to host cell (GO:0019062)3.95083267
16adhesion of symbiont to host cell (GO:0044650)3.95083267
17Rap protein signal transduction (GO:0032486)3.94846754
18regulation of chemokine-mediated signaling pathway (GO:0070099)3.90189987
19presynaptic membrane organization (GO:0097090)3.86266540
20regulation of collateral sprouting (GO:0048670)3.84505977
21myelination in peripheral nervous system (GO:0022011)3.83965579
22peripheral nervous system axon ensheathment (GO:0032292)3.83965579
23response to peptidoglycan (GO:0032494)3.83355291
24transmission of nerve impulse (GO:0019226)3.75746681
25glycosphingolipid catabolic process (GO:0046479)3.75369317
26membrane assembly (GO:0071709)3.75084009
27regulation of vitamin D biosynthetic process (GO:0060556)3.73422290
28limb bud formation (GO:0060174)3.73386983
29neuron cell-cell adhesion (GO:0007158)3.73325666
30photoreceptor cell differentiation (GO:0046530)3.64759193
31eye photoreceptor cell differentiation (GO:0001754)3.64759193
32glycerophospholipid catabolic process (GO:0046475)3.63687443
33* substantia nigra development (GO:0021762)3.60478529
34cerebral cortex radially oriented cell migration (GO:0021799)3.59613998
35peptidyl-tyrosine autophosphorylation (GO:0038083)3.58000565
36positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.57540965
37astrocyte development (GO:0014002)3.56593322
38positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.52194712
39cellular response to thyroid hormone stimulus (GO:0097067)3.52098211
40oligodendrocyte differentiation (GO:0048709)3.50179626
41sterol biosynthetic process (GO:0016126)3.48412981
42cellular response to epinephrine stimulus (GO:0071872)3.48222196
43positive regulation of actin filament depolymerization (GO:0030836)3.46392775
44negative regulation of axon extension (GO:0030517)3.40348997
45isoprenoid biosynthetic process (GO:0008299)3.37595492
46oligosaccharide catabolic process (GO:0009313)3.36893970
47macrophage activation involved in immune response (GO:0002281)3.35373824
48phagocytosis, engulfment (GO:0006911)3.30635462
49negative regulation of axonogenesis (GO:0050771)3.29079935
50positive regulation of action potential (GO:0045760)3.28628442
51retina vasculature morphogenesis in camera-type eye (GO:0061299)3.26409005
52glycolipid catabolic process (GO:0019377)3.21875350
53regulation of mononuclear cell migration (GO:0071675)3.21064243
54regulation of cell communication by electrical coupling (GO:0010649)3.20185161
55iron ion import (GO:0097286)3.19178250
56T-helper 1 type immune response (GO:0042088)3.17128583
57asymmetric protein localization (GO:0008105)3.15251332
58regulation of monocyte chemotaxis (GO:0090025)3.15094978
59negative regulation of protein localization to cell surface (GO:2000009)3.13482643
60response to redox state (GO:0051775)3.12303468
61ceramide catabolic process (GO:0046514)3.11219175
62regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.10741939
63negative regulation of nitric oxide biosynthetic process (GO:0045019)3.09884498
64cell adhesion mediated by integrin (GO:0033627)3.08240766
65regulation of memory T cell differentiation (GO:0043380)3.07196563
66response to epinephrine (GO:0071871)3.06944666
67positive regulation of interleukin-17 production (GO:0032740)3.03270480
68collagen fibril organization (GO:0030199)3.01381386
69positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.00094356
70neuronal ion channel clustering (GO:0045161)2.99827088
71neutrophil activation involved in immune response (GO:0002283)2.98628729
72regulation of fever generation (GO:0031620)2.97041993
73protein targeting to lysosome (GO:0006622)2.96639149
74establishment of protein localization to vacuole (GO:0072666)2.96639149
75protein targeting to vacuole (GO:0006623)2.96639149
76detection of external biotic stimulus (GO:0098581)2.96523983
77adhesion of symbiont to host (GO:0044406)2.96481757
78peripheral nervous system development (GO:0007422)2.95298241
79wound healing, spreading of epidermal cells (GO:0035313)2.95281822
80positive regulation of cellular amide metabolic process (GO:0034250)2.92911438
81cellular response to monoamine stimulus (GO:0071868)2.91757139
82cellular response to catecholamine stimulus (GO:0071870)2.91757139
83membrane invagination (GO:0010324)2.90034388
84positive regulation of monocyte chemotaxis (GO:0090026)2.89665058
85cellular response to ethanol (GO:0071361)2.88280994
86apical protein localization (GO:0045176)2.86883806
87import into cell (GO:0098657)2.86404459
88neurotransmitter catabolic process (GO:0042135)2.85364541
89cellular extravasation (GO:0045123)2.84676904
90regulation of interferon-alpha production (GO:0032647)2.83589574
91protein localization to endosome (GO:0036010)2.79985585
92negative regulation of anoikis (GO:2000811)2.79703831
93cellular response to interferon-alpha (GO:0035457)2.79239794
94positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.77707831
95regulation of macrophage cytokine production (GO:0010935)2.77561623
96modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.77417020
97positive regulation by organism of defense response of other organism involved in symbiotic interact2.77417020
98modulation by symbiont of host immune response (GO:0052553)2.77417020
99positive regulation by symbiont of host defense response (GO:0052509)2.77417020
100modulation by symbiont of host defense response (GO:0052031)2.77417020
101modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.77417020
102positive regulation of T-helper cell differentiation (GO:0045624)2.76434344
103neuron recognition (GO:0008038)2.76013791
104response to monoamine (GO:0071867)2.75848476
105response to catecholamine (GO:0071869)2.75848476
106detection of other organism (GO:0098543)2.74730284
107histamine secretion (GO:0001821)2.72849137
108response to lipoprotein particle (GO:0055094)2.72369717
109dermatan sulfate biosynthetic process (GO:0030208)2.72288859
110protein neddylation (GO:0045116)2.70623525
111enteric nervous system development (GO:0048484)2.70313714
112regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.70231570
113positive regulation of leukocyte degranulation (GO:0043302)2.69065405
114microglial cell activation (GO:0001774)2.68654855
115regulation of homotypic cell-cell adhesion (GO:0034110)2.68044247
116nerve growth factor signaling pathway (GO:0038180)2.67434760
117regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.67260419
118negative regulation of interleukin-17 production (GO:0032700)2.66693678
119negative regulation of mast cell activation (GO:0033004)2.64631254
120amino sugar catabolic process (GO:0046348)2.64506690
121positive regulation of macrophage cytokine production (GO:0060907)2.63132283
122regulation of interferon-beta biosynthetic process (GO:0045357)2.62135258
123keratan sulfate catabolic process (GO:0042340)2.61413131
124dendrite morphogenesis (GO:0048813)2.60897878
125magnesium ion transport (GO:0015693)2.60831746
126regulation of dendrite morphogenesis (GO:0048814)2.60779577
127regulation of mast cell activation (GO:0033003)2.60111611
128L-amino acid import (GO:0043092)2.59915765
129establishment of mitochondrion localization (GO:0051654)2.59902167
130regulation of nitric oxide biosynthetic process (GO:0045428)2.59354761
131detection of biotic stimulus (GO:0009595)2.58981103
132cellular response to hepatocyte growth factor stimulus (GO:0035729)2.58835303
133response to hepatocyte growth factor (GO:0035728)2.58835303
134positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.57324517
135macrophage activation (GO:0042116)2.57097412
136adult walking behavior (GO:0007628)2.56231482
137cerebellar granule cell differentiation (GO:0021707)2.55455998
138glial cell migration (GO:0008347)2.54691595
139positive regulation of toll-like receptor signaling pathway (GO:0034123)2.54536350
140osteoclast differentiation (GO:0030316)2.54249307
141interleukin-6-mediated signaling pathway (GO:0070102)2.54073732
142positive regulation of mast cell degranulation (GO:0043306)2.53944487
143positive regulation of mast cell activation involved in immune response (GO:0033008)2.53944487
144negative regulation of axon extension involved in axon guidance (GO:0048843)2.53499013
145positive regulation of interleukin-6 production (GO:0032755)2.52864360
146regulation of T-helper 1 cell differentiation (GO:0045625)2.52766234
147positive regulation of interferon-alpha production (GO:0032727)2.52335879
148regulation of heat generation (GO:0031650)2.52203187
149positive regulation of type 2 immune response (GO:0002830)2.51847548
150dendritic spine morphogenesis (GO:0060997)2.51581492
151lipopolysaccharide-mediated signaling pathway (GO:0031663)2.51420015
152positive regulation of gamma-delta T cell activation (GO:0046645)2.50943764
153Notch signaling involved in heart development (GO:0061314)2.49799518
154axon extension involved in axon guidance (GO:0048846)2.48800948
155neuron projection extension involved in neuron projection guidance (GO:1902284)2.48800948
156chondrocyte development (GO:0002063)2.48750038
157* neural nucleus development (GO:0048857)2.48264347
158chondroitin sulfate biosynthetic process (GO:0030206)2.47468064
159positive regulation of mast cell activation (GO:0033005)2.47432856
160actin filament depolymerization (GO:0030042)2.45618984
161Golgi to plasma membrane protein transport (GO:0043001)2.45290605
162axonal fasciculation (GO:0007413)2.45272785
163negative regulation of interleukin-10 production (GO:0032693)2.44209917
164membrane tubulation (GO:0097320)2.44046029
165positive regulation of nitric oxide biosynthetic process (GO:0045429)2.43688833
166positive regulation of protein depolymerization (GO:1901881)2.43131436
167I-kappaB phosphorylation (GO:0007252)2.42794982
168phagocytosis, recognition (GO:0006910)2.42115405
169dopamine biosynthetic process (GO:0042416)2.40524093
170myelin maintenance (GO:0043217)2.40429467
171protein palmitoylation (GO:0018345)2.40127966
172response to thyroid hormone (GO:0097066)2.40012531
173nuclear pore complex assembly (GO:0051292)2.39230013
174regulation of dendritic cell antigen processing and presentation (GO:0002604)2.38732532
175positive regulation of heat generation (GO:0031652)2.38709423
176activated T cell proliferation (GO:0050798)2.38146710
177positive regulation of chemokine production (GO:0032722)2.37738794
178heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.37443978
179epithelial cell differentiation involved in prostate gland development (GO:0060742)2.37297347
180axon development (GO:0061564)2.36859335
181positive regulation of pseudopodium assembly (GO:0031274)2.36528536
182lateral sprouting from an epithelium (GO:0060601)2.36427007
183collagen catabolic process (GO:0030574)2.35787359
184dendrite development (GO:0016358)2.35338794
185negative regulation of exocytosis (GO:0045920)2.34636593
186dermatan sulfate metabolic process (GO:0030205)2.34537155
187collagen metabolic process (GO:0032963)2.34364568
188negative regulation of osteoclast differentiation (GO:0045671)2.32913959
189regulation of activation of Janus kinase activity (GO:0010533)2.32872383
190regulation of voltage-gated calcium channel activity (GO:1901385)2.32197619
191neuronal action potential propagation (GO:0019227)2.32035096
192negative regulation of axon guidance (GO:1902668)2.31097887
193amyloid precursor protein metabolic process (GO:0042982)2.30362852
194creatine metabolic process (GO:0006600)2.28031544
195phosphatidylinositol 3-kinase signaling (GO:0014065)2.27941177
196semaphorin-plexin signaling pathway (GO:0071526)2.27444191
197cell migration in hindbrain (GO:0021535)2.27003838

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.57306589
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.31658364
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.22671476
4Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.01155352
5IRF8_27001747_Chip-Seq_BMDM_Mouse2.82956371
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.68146404
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.66863475
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.63388866
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.60776141
10CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.59838883
11TAF15_26573619_Chip-Seq_HEK293_Human2.59455408
12SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.58338624
13AR_21572438_ChIP-Seq_LNCaP_Human2.53421546
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.49934404
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.49327812
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.47017823
17GATA1_22025678_ChIP-Seq_K562_Human2.45803731
18EZH2_22144423_ChIP-Seq_EOC_Human2.38971896
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32206278
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31297432
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29784399
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.29064080
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.28801443
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.27248171
25WT1_19549856_ChIP-ChIP_CCG9911_Human2.26467932
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.25382210
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.21214415
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.21076316
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.20589173
30EZH2_18974828_ChIP-Seq_MESCs_Mouse2.19683830
31RNF2_18974828_ChIP-Seq_MESCs_Mouse2.19683830
32BRD4_25478319_ChIP-Seq_HGPS_Human2.19331521
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.08786379
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.08463152
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.06859671
36MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05206440
37JARID2_20075857_ChIP-Seq_MESCs_Mouse2.03936627
38ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02528589
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.02345366
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.99468020
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.92835846
42ER_23166858_ChIP-Seq_MCF-7_Human1.91832481
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.88595930
44CJUN_26792858_Chip-Seq_BT549_Human1.86914307
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85926444
46SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83112812
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.81110935
48FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.79805853
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.78732776
50FUS_26573619_Chip-Seq_HEK293_Human1.75545014
51P300_19829295_ChIP-Seq_ESCs_Human1.75294501
52SALL4_18804426_ChIP-ChIP_XEN_Mouse1.74928138
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.74891565
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69134313
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.68469241
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67494485
57MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.67146042
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.66838919
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66691684
60TRIM28_21343339_ChIP-Seq_HEK293_Human1.61067118
61BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.59051781
62TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.55831136
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.53837108
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53754854
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50743358
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50412086
67CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.49292260
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49246782
69VDR_22108803_ChIP-Seq_LS180_Human1.45893463
70EP300_21415370_ChIP-Seq_HL-1_Mouse1.45023797
71DROSHA_22980978_ChIP-Seq_HELA_Human1.43828291
72PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43642324
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.42228088
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.42228088
75GATA2_21666600_ChIP-Seq_HMVEC_Human1.41344912
76SMAD4_21799915_ChIP-Seq_A2780_Human1.40583872
77IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40294754
78* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36399239
79IGF1R_20145208_ChIP-Seq_DFB_Human1.36389634
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35973774
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33532336
82RNF2_27304074_Chip-Seq_NSC_Mouse1.33345287
83PU_27001747_Chip-Seq_BMDM_Mouse1.32941101
84HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.32603431
85FOXM1_23109430_ChIP-Seq_U2OS_Human1.30784254
86* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29704426
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28331919
88ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28103517
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.27981186
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25897922
91NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25830605
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24269540
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23949285
94TP53_18474530_ChIP-ChIP_U2OS_Human1.23543375
95ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21411433
96* CMYC_18555785_Chip-Seq_ESCs_Mouse1.20855530
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.19742033
98* STAT3_23295773_ChIP-Seq_U87_Human1.19311166
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19129460
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14859332
101PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14801354
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14538826
103EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14431547
104STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.13980680
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13943788
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13943788
107P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13343438
108SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13067176
109SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13067176
110RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12114578
111KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11571865
112* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11068735
113SPI1_23547873_ChIP-Seq_NB4_Human1.10702865
114EWS_26573619_Chip-Seq_HEK293_Human1.10325056
115TCF4_23295773_ChIP-Seq_U87_Human1.09880448
116RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09440138
117NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09379897
118FLI1_27457419_Chip-Seq_LIVER_Mouse1.08896114
119SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08485475
120RUNX2_22187159_ChIP-Seq_PCA_Human1.07667094
121JUN_21703547_ChIP-Seq_K562_Human1.07477917
122TP53_16413492_ChIP-PET_HCT116_Human1.06938252
123E2F1_18555785_Chip-Seq_ESCs_Mouse1.06773982
124CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06170737
125SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06051548
126STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05808949
127TP63_23658742_ChIP-Seq_EP156T_Human1.05194740
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04716010
129HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04228436
130LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03331906
131PRDM14_20953172_ChIP-Seq_ESCs_Human1.03161537
132ELK1_19687146_ChIP-ChIP_HELA_Human1.02838148
133SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.02651851
134SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02605764
135P300_18555785_Chip-Seq_ESCs_Mouse1.02456823
136P53_22387025_ChIP-Seq_ESCs_Mouse1.01782206
137PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99688713
138SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99411224
139FLI1_21867929_ChIP-Seq_TH2_Mouse0.98730718
140SOX9_26525672_Chip-Seq_HEART_Mouse0.97946437
141KDM2B_26808549_Chip-Seq_REH_Human0.97517127
142PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97415750
143POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97162769
144BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97159032
145TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96740744
146SOX2_21211035_ChIP-Seq_LN229_Gbm0.96459054
147VDR_24787735_ChIP-Seq_THP-1_Human0.96297632
148KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95316180
149E2F7_22180533_ChIP-Seq_HELA_Human0.95301898
150SCL_19346495_ChIP-Seq_HPC-7_Human0.95279532
151REST_21632747_ChIP-Seq_MESCs_Mouse0.95205567
152SPI1_23127762_ChIP-Seq_K562_Human0.94980497
153TFEB_21752829_ChIP-Seq_HELA_Human0.94911796
154MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94802299
155RING1B_27294783_Chip-Seq_NPCs_Mouse0.94739986
156IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94521175
157AR_25329375_ChIP-Seq_VCAP_Human0.94255200
158EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93890500
159FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93426905
160JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91581386

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.37622384
2MP0000920_abnormal_myelination3.99786208
3MP0006054_spinal_hemorrhage3.82028937
4MP0003303_peritoneal_inflammation3.13788481
5MP0002877_abnormal_melanocyte_morpholog3.12102990
6MP0003724_increased_susceptibility_to3.11423392
7MP0003880_abnormal_central_pattern3.07394685
8MP0004270_analgesia2.90863013
9MP0003705_abnormal_hypodermis_morpholog2.89272391
10MP0001348_abnormal_lacrimal_gland2.84168054
11MP0005275_abnormal_skin_tensile2.71920339
12MP0005171_absent_coat_pigmentation2.63601807
13MP0003300_gastrointestinal_ulcer2.60739367
14MP0006082_CNS_inflammation2.57426486
15MP0000778_abnormal_nervous_system2.51359143
16MP0001905_abnormal_dopamine_level2.48572601
17MP0001346_abnormal_lacrimal_gland2.48087727
18MP0001958_emphysema2.44748211
19MP0004859_abnormal_synaptic_plasticity2.39017795
20MP0003279_aneurysm2.34884674
21MP0005058_abnormal_lysosome_morphology2.33876124
22MP0005409_darkened_coat_color2.32973884
23MP0003690_abnormal_glial_cell2.22186649
24MP0004742_abnormal_vestibular_system2.19515245
25MP0002734_abnormal_mechanical_nocicepti2.18108989
26MP0002272_abnormal_nervous_system2.12637938
27MP0005257_abnormal_intraocular_pressure2.09016267
28MP0001529_abnormal_vocalization2.01625667
29MP0010352_gastrointestinal_tract_polyps1.95076742
30MP0001835_abnormal_antigen_presentation1.90219276
31MP0003828_pulmonary_edema1.89649571
32MP0001968_abnormal_touch/_nociception1.88417733
33MP0001486_abnormal_startle_reflex1.84916333
34MP0002064_seizures1.84912535
35MP0009046_muscle_twitch1.84664336
36MP0008438_abnormal_cutaneous_collagen1.83706324
37MP0003448_altered_tumor_morphology1.82657437
38MP0000343_altered_response_to1.82437616
39MP0004134_abnormal_chest_morphology1.82010550
40MP0003136_yellow_coat_color1.81867502
41MP0009745_abnormal_behavioral_response1.79395817
42MP0002735_abnormal_chemical_nociception1.77318851
43MP0005423_abnormal_somatic_nervous1.75944466
44MP0003635_abnormal_synaptic_transmissio1.75404710
45MP0002419_abnormal_innate_immunity1.73580716
46MP0001299_abnormal_eye_distance/1.73537787
47MP0003191_abnormal_cellular_cholesterol1.72743967
48MP0003950_abnormal_plasma_membrane1.72408303
49MP0003634_abnormal_glial_cell1.70912991
50MP0003566_abnormal_cell_adhesion1.70508159
51MP0009764_decreased_sensitivity_to1.67092351
52MP0005248_abnormal_Harderian_gland1.66036581
53MP0002009_preneoplasia1.64816811
54MP0002148_abnormal_hypersensitivity_rea1.63550331
55MP0002163_abnormal_gland_morphology1.61730857
56MP0002736_abnormal_nociception_after1.56347390
57MP0001485_abnormal_pinna_reflex1.53829086
58MP0002733_abnormal_thermal_nociception1.52342611
59MP0004272_abnormal_basement_membrane1.51980141
60MP0005503_abnormal_tendon_morphology1.49016218
61MP0005174_abnormal_tail_pigmentation1.48194754
62MP0000767_abnormal_smooth_muscle1.45497584
63MP0004883_abnormal_blood_vessel1.44815276
64MP0004147_increased_porphyrin_level1.42938875
65MP0004142_abnormal_muscle_tone1.42366150
66MP0005623_abnormal_meninges_morphology1.40504412
67MP0001542_abnormal_bone_strength1.39231558
68MP0001970_abnormal_pain_threshold1.38464657
69MP0002102_abnormal_ear_morphology1.37924651
70MP0001440_abnormal_grooming_behavior1.35763649
71MP0003632_abnormal_nervous_system1.35056818
72MP0000015_abnormal_ear_pigmentation1.35023841
73MP0000955_abnormal_spinal_cord1.34077247
74MP0005164_abnormal_response_to1.32948949
75MP0000372_irregular_coat_pigmentation1.31923865
76MP0009250_abnormal_appendicular_skeleto1.30919502
77MP0002063_abnormal_learning/memory/cond1.30690164
78MP0003172_abnormal_lysosome_physiology1.30558503
79MP0001853_heart_inflammation1.29918085
80MP0000462_abnormal_digestive_system1.28825978
81MP0004885_abnormal_endolymph1.28738359
82MP0002882_abnormal_neuron_morphology1.26570833
83MP0002067_abnormal_sensory_capabilities1.25021407
84MP0004510_myositis1.24870749
85MP0002896_abnormal_bone_mineralization1.23716006
86MP0003937_abnormal_limbs/digits/tail_de1.23703984
87MP0005645_abnormal_hypothalamus_physiol1.23500420
88MP0003329_amyloid_beta_deposits1.23187059
89MP0008004_abnormal_stomach_pH1.22890883
90MP0002572_abnormal_emotion/affect_behav1.22759257
91MP0005310_abnormal_salivary_gland1.22136989
92MP0002295_abnormal_pulmonary_circulatio1.22063428
93MP0005386_behavior/neurological_phenoty1.21013073
94MP0004924_abnormal_behavior1.21013073
95MP0003221_abnormal_cardiomyocyte_apopto1.20843329
96MP0001533_abnormal_skeleton_physiology1.19282678
97MP0010307_abnormal_tumor_latency1.18557135
98MP0000371_diluted_coat_color1.16370892
99MP0002998_abnormal_bone_remodeling1.16356694
100MP0005595_abnormal_vascular_smooth1.16152228
101MP0002332_abnormal_exercise_endurance1.16134798
102MP0001243_abnormal_dermal_layer1.12574370
103MP0002184_abnormal_innervation1.11284620
104MP0003075_altered_response_to1.10889726
105MP0006276_abnormal_autonomic_nervous1.10810066
106MP0009785_altered_susceptibility_to1.09826013
107MP0005167_abnormal_blood-brain_barrier1.08620369
108MP0009384_cardiac_valve_regurgitation1.08036801
109MP0002066_abnormal_motor_capabilities/c1.06790509
110MP0003183_abnormal_peptide_metabolism1.06044491
111MP0002229_neurodegeneration1.05859317
112MP0002452_abnormal_antigen_presenting1.05389400
113MP0000465_gastrointestinal_hemorrhage1.04335475
114MP0003436_decreased_susceptibility_to1.03559670
115MP0002090_abnormal_vision1.03217770
116MP0002060_abnormal_skin_morphology1.02315529
117MP0002254_reproductive_system_inflammat1.01816693
118MP0005379_endocrine/exocrine_gland_phen1.01710366
119MP0000383_abnormal_hair_follicle1.01463054
120MP0004808_abnormal_hematopoietic_stem1.01014445
121MP0003385_abnormal_body_wall1.00245672
122MP0002752_abnormal_somatic_nervous0.99940390
123MP0008057_abnormal_DNA_replication0.99296070
124MP0002938_white_spotting0.99236576
125MP0010678_abnormal_skin_adnexa0.98809495
126MP0001188_hyperpigmentation0.96812555
127MP0008569_lethality_at_weaning0.96306762
128MP0002095_abnormal_skin_pigmentation0.94494285
129MP0001963_abnormal_hearing_physiology0.92621045
130MP0001915_intracranial_hemorrhage0.92102246
131MP0000427_abnormal_hair_cycle0.91767926
132MP0001986_abnormal_taste_sensitivity0.91008888
133MP0001545_abnormal_hematopoietic_system0.90704676
134MP0005397_hematopoietic_system_phenotyp0.90704676
135MP0003938_abnormal_ear_development0.90349527
136MP0003453_abnormal_keratinocyte_physiol0.89266339
137MP0005197_abnormal_uvea_morphology0.88570672
138MP0000647_abnormal_sebaceous_gland0.88562631
139MP0003091_abnormal_cell_migration0.88374409
140MP0009379_abnormal_foot_pigmentation0.87546777
141MP0010368_abnormal_lymphatic_system0.87212242
142MP0005000_abnormal_immune_tolerance0.86874732
143MP0002751_abnormal_autonomic_nervous0.86154622
144MP0005025_abnormal_response_to0.86052213
145MP0000428_abnormal_craniofacial_morphol0.83458540
146MP0005508_abnormal_skeleton_morphology0.83411044
147MP0005390_skeleton_phenotype0.82837188
148MP0002108_abnormal_muscle_morphology0.82430668
149MP0003631_nervous_system_phenotype0.81896985
150MP0001177_atelectasis0.81227712
151MP0002152_abnormal_brain_morphology0.81005646
152MP0000858_altered_metastatic_potential0.80163101
153MP0001879_abnormal_lymphatic_vessel0.80141381
154MP0000631_abnormal_neuroendocrine_gland0.79022094
155MP0002723_abnormal_immune_serum0.77869743
156MP0005387_immune_system_phenotype0.76367440
157MP0001790_abnormal_immune_system0.76367440
158MP0000026_abnormal_inner_ear0.75309812
159MP0010234_abnormal_vibrissa_follicle0.75280720
160MP0001661_extended_life_span0.75119797
161MP0004811_abnormal_neuron_physiology0.74995282
162MP0009278_abnormal_bone_marrow0.74954944
163MP0002177_abnormal_outer_ear0.74562938
164MP0005165_increased_susceptibility_to0.74514779
165MP0003795_abnormal_bone_structure0.73798772
166MP0008260_abnormal_autophagy0.72354264
167MP0008775_abnormal_heart_ventricle0.72302688
168MP0002933_joint_inflammation0.71733101
169MP0003122_maternal_imprinting0.71618701
170MP0005023_abnormal_wound_healing0.71500320
171MP0004947_skin_inflammation0.70439963
172MP0002133_abnormal_respiratory_system0.70222040
173MP0005388_respiratory_system_phenotype0.70222040
174MP0002115_abnormal_skeleton_extremities0.69328167
175MP0001851_eye_inflammation0.63900658
176MP0000604_amyloidosis0.63854515
177MP0002557_abnormal_social/conspecific_i0.63743549
178MP0005646_abnormal_pituitary_gland0.61856476
179MP0001501_abnormal_sleep_pattern0.61400339
180MP0003755_abnormal_palate_morphology0.60325869

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)5.87192952
2Abnormality of glycosphingolipid metabolism (HP:0004343)5.87192952
3Abnormality of glycolipid metabolism (HP:0010969)5.87192952
4Degeneration of the lateral corticospinal tracts (HP:0002314)5.77668632
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.77668632
6Sensory axonal neuropathy (HP:0003390)5.24474550
7Abnormality of the corticospinal tract (HP:0002492)4.69870404
8Neurofibrillary tangles (HP:0002185)4.16041553
9Parakeratosis (HP:0001036)4.02600342
10Premature rupture of membranes (HP:0001788)4.01181452
11Small epiphyses (HP:0010585)3.60237927
12Epiphyseal dysplasia (HP:0002656)3.53768798
13Akinesia (HP:0002304)3.51679338
14Vacuolated lymphocytes (HP:0001922)3.47723092
15Insidious onset (HP:0003587)3.30571801
16Termporal pattern (HP:0011008)3.30571801
17Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.29442078
18Myocardial infarction (HP:0001658)3.12637580
19Disinhibition (HP:0000734)3.10503495
20Increased cerebral lipofuscin (HP:0011813)3.00491832
21Alacrima (HP:0000522)2.99506101
22Recurrent bacterial skin infections (HP:0005406)2.99404362
23Peritonitis (HP:0002586)2.99037020
24Spastic gait (HP:0002064)2.98140061
25Peripheral hypomyelination (HP:0007182)2.96613557
26Cortical dysplasia (HP:0002539)2.95279664
27Abnormality of the vasculature of the conjunctiva (HP:0008054)2.90963660
28Hematochezia (HP:0002573)2.88079492
29Metaphyseal dysplasia (HP:0100255)2.87160521
30Supranuclear gaze palsy (HP:0000605)2.80265037
31Atonic seizures (HP:0010819)2.79889208
32Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.79653663
33Absent frontal sinuses (HP:0002688)2.79375394
34Irregular epiphyses (HP:0010582)2.77827993
35Aortic dissection (HP:0002647)2.74515139
36Recurrent abscess formation (HP:0002722)2.72974405
37Cerebral inclusion bodies (HP:0100314)2.72596893
38Cerebral hemorrhage (HP:0001342)2.68266165
39Hypoplastic pelvis (HP:0008839)2.66032797
40Retinal dysplasia (HP:0007973)2.62444531
41Dysostosis multiplex (HP:0000943)2.62346712
42Autoamputation (HP:0001218)2.62064004
43Cupped ear (HP:0000378)2.60272428
44Spondylolisthesis (HP:0003302)2.58159965
45Abnormality of the phalanges of the 2nd finger (HP:0009541)2.52782780
46Follicular hyperkeratosis (HP:0007502)2.51690567
47Bladder diverticulum (HP:0000015)2.50787384
48Cerebral hypomyelination (HP:0006808)2.49649138
49Neuroendocrine neoplasm (HP:0100634)2.48104234
50Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.47821785
51Relative macrocephaly (HP:0004482)2.47001856
52Adrenal hypoplasia (HP:0000835)2.46662901
53Loss of speech (HP:0002371)2.46530150
54Fetal akinesia sequence (HP:0001989)2.44829732
55Pheochromocytoma (HP:0002666)2.44752628
56Absent septum pellucidum (HP:0001331)2.42154029
57Spinal cord lesions (HP:0100561)2.39490338
58Syringomyelia (HP:0003396)2.39490338
59Limb dystonia (HP:0002451)2.39269357
60Spontaneous hematomas (HP:0007420)2.38812039
61Abnormality of incisor morphology (HP:0011063)2.38715714
62Broad ribs (HP:0000885)2.37628941
63Thickened helices (HP:0000391)2.37401084
64Stomach cancer (HP:0012126)2.36957745
65Vascular tortuosity (HP:0004948)2.36585790
66Abnormality of macrophages (HP:0004311)2.35918648
67Soft skin (HP:0000977)2.35867310
68Decreased lacrimation (HP:0000633)2.34236128
69Osteolytic defects of the hand bones (HP:0009699)2.33847036
70Osteolytic defects of the phalanges of the hand (HP:0009771)2.33847036
71Eczematoid dermatitis (HP:0000976)2.33620657
72Myokymia (HP:0002411)2.32222338
73Poor head control (HP:0002421)2.30609699
74Conjunctival telangiectasia (HP:0000524)2.29406859
75Agnosia (HP:0010524)2.28783399
76Ankle contracture (HP:0006466)2.28486784
77Deep philtrum (HP:0002002)2.28353434
78Genu recurvatum (HP:0002816)2.25359414
79Thoracolumbar scoliosis (HP:0002944)2.24413492
80Intention tremor (HP:0002080)2.20710920
81Upper motor neuron abnormality (HP:0002127)2.20656484
82Aortic aneurysm (HP:0004942)2.19648116
83Optic neuritis (HP:0100653)2.17327055
84Retrobulbar optic neuritis (HP:0100654)2.17327055
85Hypothermia (HP:0002045)2.17162902
86Dilatation of the ascending aorta (HP:0005111)2.16523742
87Short middle phalanx of the 5th finger (HP:0004220)2.14906891
88Orchitis (HP:0100796)2.14830643
89Arterial tortuosity (HP:0005116)2.13486325
90Stridor (HP:0010307)2.12602824
91Abnormality of the septum pellucidum (HP:0007375)2.11963988
92Abnormal auditory evoked potentials (HP:0006958)2.11569064
93Abnormality of glycolysis (HP:0004366)2.11256100
94Increased serum pyruvate (HP:0003542)2.11256100
95Dysmetria (HP:0001310)2.10718809
96Type II lissencephaly (HP:0007260)2.10543534
97Protrusio acetabuli (HP:0003179)2.09536845
98Large earlobe (HP:0009748)2.08967212
99Slow saccadic eye movements (HP:0000514)2.07740245
100Decreased skull ossification (HP:0004331)2.05999559
101Mild short stature (HP:0003502)2.05443472
102Partial agenesis of the corpus callosum (HP:0001338)2.05313898
103Progressive inability to walk (HP:0002505)2.05310765
104Premature skin wrinkling (HP:0100678)2.05249550
105White forelock (HP:0002211)2.04488032
106Aplasia involving bones of the extremities (HP:0009825)2.04360556
107Aplasia involving bones of the upper limbs (HP:0009823)2.04360556
108Aplasia of the phalanges of the hand (HP:0009802)2.04360556
109Abnormality of skull ossification (HP:0002703)2.02595985
110Septo-optic dysplasia (HP:0100842)2.02392726
111Delayed epiphyseal ossification (HP:0002663)2.01724218
112Inappropriate behavior (HP:0000719)2.01343652
113Mediastinal lymphadenopathy (HP:0100721)2.01309474
114Epileptic encephalopathy (HP:0200134)2.00468923
115Subacute progressive viral hepatitis (HP:0006572)1.97956410
116Autoimmune thrombocytopenia (HP:0001973)1.97906588
117Lower limb muscle weakness (HP:0007340)1.97658405
118Wormian bones (HP:0002645)1.97298005
119Patchy hypopigmentation of hair (HP:0011365)1.95291024
120Congenital ichthyosiform erythroderma (HP:0007431)1.94979361
121Abnormality of glycosaminoglycan metabolism (HP:0004371)1.94072441
122Abnormality of mucopolysaccharide metabolism (HP:0011020)1.94072441
123Abnormality of polysaccharide metabolism (HP:0011012)1.94072441
124Atrophic scars (HP:0001075)1.93468404
125Infantile muscular hypotonia (HP:0008947)1.93256666
126Chin dimple (HP:0010751)1.93091464
127Apathy (HP:0000741)1.92444307
128Mucopolysacchariduria (HP:0008155)1.92122793
129Urinary glycosaminoglycan excretion (HP:0003541)1.92122793
130Mutism (HP:0002300)1.91648267
131Leukodystrophy (HP:0002415)1.88195079
132Myelomeningocele (HP:0002475)1.88140589
133Ankle clonus (HP:0011448)1.88050196
134Conical tooth (HP:0000698)1.87483687
135Abnormality of the frontal sinuses (HP:0002687)1.87224573
136Anteriorly placed anus (HP:0001545)1.86764128
137Scanning speech (HP:0002168)1.85725252
138Diminished movement (HP:0002374)1.85093622
139Pulmonary artery stenosis (HP:0004415)1.83463939
140* Onion bulb formation (HP:0003383)1.83177138
141Myositis (HP:0100614)1.82921819
142Mitral valve prolapse (HP:0001634)1.82702629
143Overgrowth (HP:0001548)1.82429270
144Increased neuronal autofluorescent lipopigment (HP:0002074)1.82211322
145Diminished motivation (HP:0000745)1.80585621
146Cerebral aneurysm (HP:0004944)1.80197098
147Hypoplasia of the iris (HP:0007676)1.79840052
148Ulnar claw (HP:0001178)1.79484240
149Coronal craniosynostosis (HP:0004440)1.79404751
150Anomalous pulmonary venous return (HP:0010772)1.78053627
151Abnormality of the periventricular white matter (HP:0002518)1.76750071
152Mixed hearing impairment (HP:0000410)1.76731280
153Bowel diverticulosis (HP:0005222)1.76191446
154Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.76093793
155Humeroradial synostosis (HP:0003041)1.75698840
156Synostosis involving the elbow (HP:0003938)1.75698840
157Renal Fanconi syndrome (HP:0001994)1.74814432
158Widely spaced teeth (HP:0000687)1.74709505
159Hypoplastic ischia (HP:0003175)1.74684603
160Abnormal hair whorl (HP:0010721)1.73348402
161Abnormality of the vitreous humor (HP:0004327)1.72379811
162Broad-based gait (HP:0002136)1.72350939
163Pulmonic stenosis (HP:0001642)1.71918596
164Blue sclerae (HP:0000592)1.70497437
165Asymmetry of the thorax (HP:0001555)1.70388722
166Abnormality of the parathyroid morphology (HP:0011766)1.69262641
167Prostate neoplasm (HP:0100787)1.69262529
168Barrel-shaped chest (HP:0001552)1.68311647
169Albinism (HP:0001022)1.67724488
170Buphthalmos (HP:0000557)1.67466226
171Esophageal varix (HP:0002040)1.66822004
172Focal seizures (HP:0007359)1.66350760
173Heterochromia iridis (HP:0001100)1.62570485
174Meningocele (HP:0002435)1.62407275
175Abnormality of the pulmonary veins (HP:0011718)1.62295840
176Absent hand (HP:0004050)1.61284326
177Hypomagnesemia (HP:0002917)1.60940123
178Abnormality of the femoral head (HP:0003368)1.60175379
179Abnormality of the middle phalanges of the toes (HP:0010183)1.60045544
180Mitral stenosis (HP:0001718)1.59342397
181Clumsiness (HP:0002312)1.59138208
182Acute myeloid leukemia (HP:0004808)1.59082416
183Hemoptysis (HP:0002105)1.58826871
184Flat cornea (HP:0007720)1.58683207
185Recurrent skin infections (HP:0001581)1.54200595
186Periodontitis (HP:0000704)1.53708067
187Global brain atrophy (HP:0002283)1.52670917
188Hepatosplenomegaly (HP:0001433)1.52086587
189Curly hair (HP:0002212)1.51764549
190Mucosal telangiectasiae (HP:0100579)1.47302124
191Transitional cell carcinoma of the bladder (HP:0006740)1.47177012
192Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.46716440
193Bladder carcinoma (HP:0002862)1.46490119
194Bladder neoplasm (HP:0009725)1.46490119

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.20033541
2STK395.06196027
3BCR3.44964836
4TGFBR23.30518945
5OXSR13.19721132
6EPHB12.93652771
7NEK92.92988627
8GRK72.54941232
9PKN12.25110982
10BLK2.23676752
11CDK62.15396500
12ERBB32.09560835
13PDGFRA2.09554696
14LIMK12.04259599
15ACVR1B1.99545790
16PBK1.96176745
17PAK61.91244119
18PRPF4B1.85075644
19CASK1.83632871
20MAP3K131.79932143
21MARK11.78543348
22NEK61.75665792
23MAPK131.74199276
24CDK191.73043140
25MAP3K61.72251733
26CAMKK21.72050014
27FGFR21.70659607
28CSNK1G31.70485645
29BMPR1B1.68405409
30JAK31.67805935
31WNK41.66350673
32UHMK11.64722199
33LATS21.62495297
34TYK21.60979810
35MAP3K141.58177292
36NTRK11.57039268
37CSNK1A1L1.55568374
38CCNB11.50630930
39MAPKAPK51.46701548
40TGFBR11.36303702
41CSNK1G21.34822348
42CSNK1G11.33857831
43MET1.31997789
44RIPK11.29858870
45JAK11.27007078
46WNK11.25448924
47DYRK21.25319173
48PAK31.23636801
49IRAK31.23113777
50ROCK21.22076276
51FGR1.21665364
52FER1.20369329
53MATK1.19599660
54JAK21.18010035
55LATS11.16778054
56PIK3CG1.12911005
57TYRO31.10858360
58RPS6KA41.08585744
59EPHA31.03412409
60PDK21.02126886
61CSK1.01918633
62WEE11.01287490
63PAK21.00492011
64MAP2K30.98701834
65MAP3K40.98493397
66BRSK20.98374893
67CDK140.97141313
68MST40.95258474
69YES10.94269825
70ERBB40.93714622
71DYRK30.91149186
72FLT30.91125943
73FES0.91062690
74ICK0.90947306
75STK30.89559779
76KSR20.88928317
77CDK50.86187020
78EPHA40.85691573
79TIE10.83348122
80PLK20.83063264
81PRKCQ0.83031861
82PRKCE0.82089522
83TTN0.81061619
84CLK10.79916766
85PLK40.79872034
86CAMK2D0.78971167
87ARAF0.75631004
88CAMK2B0.75613144
89ROCK10.75305190
90EIF2AK30.75175028
91GRK50.74977365
92STK100.73389562
93EGFR0.72980601
94CAMK2A0.71445006
95CDK150.71131454
96BRD40.70464577
97CDK180.70308666
98NUAK10.69706962
99MARK20.69531808
100MINK10.68914905
101ABL10.68809957
102BMPR20.68786440
103PAK40.67135362
104TEC0.66301134
105HCK0.65774061
106CDK11A0.64431243
107MUSK0.63607368
108DDR20.63517310
109MKNK20.63315790
110EIF2AK20.63209575
111PKN20.61657306
112MAPK70.61579053
113FRK0.59800593
114MAP2K70.59574208
115IRAK10.58941057
116ZAP700.58649229
117CAMK1D0.58010865
118PIK3CA0.57066198
119FYN0.56737783
120IKBKB0.56193979
121PTK2B0.54384895
122TRPM70.52817068
123MAP3K30.52738403
124RET0.50667773
125GSK3A0.50179059
126PDGFRB0.49818014
127LYN0.49694941
128SGK4940.48613428
129SGK2230.48613428
130MOS0.47851372
131NLK0.47748901
132CAMK2G0.47524709
133STK240.46865202
134MKNK10.45874392
135MAP3K90.44663767
136DMPK0.44484562
137CAMK1G0.44035269
138KSR10.42176245
139EPHB20.42156566
140STK38L0.41408676
141PHKG20.41277577
142PHKG10.41277577
143TAF10.40911808
144IRAK40.40807400
145NTRK20.40576206
146IGF1R0.40209879
147PLK30.39999136
148OBSCN0.39129699
149PRKG10.38168404
150RAF10.37437472
151MAP3K20.37221558
152ADRBK20.36558520
153IRAK20.36057589
154NTRK30.35321038
155IKBKE0.34494832
156ADRBK10.32894819
157MELK0.31124006
158ABL20.29781605
159INSR0.29350287
160KIT0.29185017

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.44114596
2Steroid biosynthesis_Homo sapiens_hsa001003.46250723
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.67888335
4Lysosome_Homo sapiens_hsa041422.33144313
5Axon guidance_Homo sapiens_hsa043602.25822862
6Ether lipid metabolism_Homo sapiens_hsa005652.25275724
7Other glycan degradation_Homo sapiens_hsa005112.11215921
8Osteoclast differentiation_Homo sapiens_hsa043802.03508503
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.01582900
10Leishmaniasis_Homo sapiens_hsa051402.01136904
11Fatty acid elongation_Homo sapiens_hsa000621.91752890
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.83625954
13Tuberculosis_Homo sapiens_hsa051521.80816013
14Legionellosis_Homo sapiens_hsa051341.80760185
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.80032945
16Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.72105263
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66724238
18Staphylococcus aureus infection_Homo sapiens_hsa051501.64773496
19* Serotonergic synapse_Homo sapiens_hsa047261.63715720
20Oxidative phosphorylation_Homo sapiens_hsa001901.61213827
21Pertussis_Homo sapiens_hsa051331.57813403
22Toxoplasmosis_Homo sapiens_hsa051451.52892973
23TNF signaling pathway_Homo sapiens_hsa046681.49813048
24Long-term depression_Homo sapiens_hsa047301.47563299
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.44050793
26Sphingolipid metabolism_Homo sapiens_hsa006001.43881949
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.43587990
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.38136904
29* Glutamatergic synapse_Homo sapiens_hsa047241.35697428
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.33431377
31Parkinsons disease_Homo sapiens_hsa050121.32699598
32Amoebiasis_Homo sapiens_hsa051461.32057730
33Hepatitis B_Homo sapiens_hsa051611.30066520
34Renal cell carcinoma_Homo sapiens_hsa052111.29433704
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.27394053
36ECM-receptor interaction_Homo sapiens_hsa045121.27074027
37Rheumatoid arthritis_Homo sapiens_hsa053231.26599774
38Influenza A_Homo sapiens_hsa051641.25549798
39Autoimmune thyroid disease_Homo sapiens_hsa053201.23432691
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20573209
41Pancreatic cancer_Homo sapiens_hsa052121.20428521
42Alzheimers disease_Homo sapiens_hsa050101.20358983
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18585913
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.18247998
45Phospholipase D signaling pathway_Homo sapiens_hsa040721.16225239
46Ovarian steroidogenesis_Homo sapiens_hsa049131.12598211
47Sphingolipid signaling pathway_Homo sapiens_hsa040711.12177928
48* Cholinergic synapse_Homo sapiens_hsa047251.11282860
49Chronic myeloid leukemia_Homo sapiens_hsa052201.11259481
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10943859
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10224409
52* Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09959291
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.09681458
54Measles_Homo sapiens_hsa051621.07928881
55Malaria_Homo sapiens_hsa051441.07885766
56* Ras signaling pathway_Homo sapiens_hsa040141.06616247
57MicroRNAs in cancer_Homo sapiens_hsa052061.05870501
58* Morphine addiction_Homo sapiens_hsa050321.04664669
59* GABAergic synapse_Homo sapiens_hsa047271.04278757
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02993773
61Small cell lung cancer_Homo sapiens_hsa052221.02978427
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01865855
63Jak-STAT signaling pathway_Homo sapiens_hsa046301.01818487
64Bladder cancer_Homo sapiens_hsa052191.01616974
65Protein export_Homo sapiens_hsa030601.00404699
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97906595
67ErbB signaling pathway_Homo sapiens_hsa040120.97011549
68Prolactin signaling pathway_Homo sapiens_hsa049170.96890120
69Dorso-ventral axis formation_Homo sapiens_hsa043200.94683911
70Proteoglycans in cancer_Homo sapiens_hsa052050.92862556
71Allograft rejection_Homo sapiens_hsa053300.92468573
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92423229
73Gap junction_Homo sapiens_hsa045400.91691040
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.90994856
75Cardiac muscle contraction_Homo sapiens_hsa042600.90937316
76Vibrio cholerae infection_Homo sapiens_hsa051100.90307782
77Nicotine addiction_Homo sapiens_hsa050330.90265088
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88495370
79* Dopaminergic synapse_Homo sapiens_hsa047280.88331840
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.88060536
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87459838
82Shigellosis_Homo sapiens_hsa051310.87030632
83* Circadian entrainment_Homo sapiens_hsa047130.86225393
84Focal adhesion_Homo sapiens_hsa045100.85196845
85Tight junction_Homo sapiens_hsa045300.82964954
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82804223
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82241655
88Endocytosis_Homo sapiens_hsa041440.80129222
89Cocaine addiction_Homo sapiens_hsa050300.80114715
90Oxytocin signaling pathway_Homo sapiens_hsa049210.80091708
91Antigen processing and presentation_Homo sapiens_hsa046120.80057851
92Herpes simplex infection_Homo sapiens_hsa051680.80014293
93Phagosome_Homo sapiens_hsa041450.79884376
94Adherens junction_Homo sapiens_hsa045200.79734207
95Hepatitis C_Homo sapiens_hsa051600.79043208
96Choline metabolism in cancer_Homo sapiens_hsa052310.78831605
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78678223
98Hematopoietic cell lineage_Homo sapiens_hsa046400.77566096
99Dilated cardiomyopathy_Homo sapiens_hsa054140.76370001
100Apoptosis_Homo sapiens_hsa042100.75932822
101Synaptic vesicle cycle_Homo sapiens_hsa047210.75742920
102Renin secretion_Homo sapiens_hsa049240.75355311
103Salivary secretion_Homo sapiens_hsa049700.75332826
104Viral myocarditis_Homo sapiens_hsa054160.74980972
105Olfactory transduction_Homo sapiens_hsa047400.74726161
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72421348
107Colorectal cancer_Homo sapiens_hsa052100.72409450
108* Chemokine signaling pathway_Homo sapiens_hsa040620.72124614
109B cell receptor signaling pathway_Homo sapiens_hsa046620.71746643
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71559205
111Collecting duct acid secretion_Homo sapiens_hsa049660.70958826
112Salmonella infection_Homo sapiens_hsa051320.69738165
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69459576
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.69043741
115* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67924250
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.67817611
117Huntingtons disease_Homo sapiens_hsa050160.67702957
118MAPK signaling pathway_Homo sapiens_hsa040100.67020188
119Taste transduction_Homo sapiens_hsa047420.65720009
120Platelet activation_Homo sapiens_hsa046110.65401889
121p53 signaling pathway_Homo sapiens_hsa041150.64986951
122GnRH signaling pathway_Homo sapiens_hsa049120.64338859
123Proteasome_Homo sapiens_hsa030500.63675496
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63100131
125TGF-beta signaling pathway_Homo sapiens_hsa043500.63092871
126Acute myeloid leukemia_Homo sapiens_hsa052210.62804279
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62459000
128* Pathways in cancer_Homo sapiens_hsa052000.61999085
129Viral carcinogenesis_Homo sapiens_hsa052030.61876046
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61279162
131cAMP signaling pathway_Homo sapiens_hsa040240.61261725
132African trypanosomiasis_Homo sapiens_hsa051430.60441449
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60182880
134Endometrial cancer_Homo sapiens_hsa052130.59282626
135Linoleic acid metabolism_Homo sapiens_hsa005910.58518010
136Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58255570
137Long-term potentiation_Homo sapiens_hsa047200.57418024
138alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56536910
139Graft-versus-host disease_Homo sapiens_hsa053320.55642964
140Non-small cell lung cancer_Homo sapiens_hsa052230.55327991
141HIF-1 signaling pathway_Homo sapiens_hsa040660.55176815
142Hippo signaling pathway_Homo sapiens_hsa043900.53854532
143NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53478979
144Central carbon metabolism in cancer_Homo sapiens_hsa052300.53255684
145Rap1 signaling pathway_Homo sapiens_hsa040150.52760278
146Amphetamine addiction_Homo sapiens_hsa050310.52673564
147Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52313222
148Melanoma_Homo sapiens_hsa052180.52277142
149Estrogen signaling pathway_Homo sapiens_hsa049150.51199786
150Prostate cancer_Homo sapiens_hsa052150.50630864
151Gastric acid secretion_Homo sapiens_hsa049710.50531306
152Hedgehog signaling pathway_Homo sapiens_hsa043400.50344380
153Glioma_Homo sapiens_hsa052140.47746132
154Arachidonic acid metabolism_Homo sapiens_hsa005900.47366890
155Asthma_Homo sapiens_hsa053100.47099729
156HTLV-I infection_Homo sapiens_hsa051660.46501838
157Calcium signaling pathway_Homo sapiens_hsa040200.46250847
158FoxO signaling pathway_Homo sapiens_hsa040680.45855666
159Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45044694
160Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44576888
161Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42469680
162mTOR signaling pathway_Homo sapiens_hsa041500.42187936
163Prion diseases_Homo sapiens_hsa050200.41973875
164Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41732784

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