GNAT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in rods. This gene is also expressed in other cells, and has been implicated in bitter taste transduction in rat taste cells. Mutations in this gene result in autosomal dominant congenital stationary night blindness. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* phototransduction (GO:0007602)9.88544782
2* phototransduction, visible light (GO:0007603)9.71689311
3GMP metabolic process (GO:0046037)9.61047580
4* detection of light stimulus involved in visual perception (GO:0050908)9.46929340
5* detection of light stimulus involved in sensory perception (GO:0050962)9.46929340
6* detection of light stimulus (GO:0009583)9.35882950
7* detection of visible light (GO:0009584)9.23894478
8regulation of guanylate cyclase activity (GO:0031282)9.22744240
9protein-chromophore linkage (GO:0018298)8.45396145
10negative regulation of cardiac muscle tissue growth (GO:0055022)8.42570177
11negative regulation of heart growth (GO:0061117)8.42570177
12negative regulation of cardiac muscle hypertrophy (GO:0010614)8.23557082
13retinal rod cell development (GO:0046548)8.04910887
14* visual perception (GO:0007601)7.97756356
15* sensory perception of light stimulus (GO:0050953)7.88103693
16negative regulation of muscle hypertrophy (GO:0014741)7.38311186
17* cellular response to light stimulus (GO:0071482)7.23653285
18regulation of cGMP metabolic process (GO:0030823)6.51309511
19* detection of external stimulus (GO:0009581)6.49643043
20* detection of abiotic stimulus (GO:0009582)6.45295363
21eye photoreceptor cell differentiation (GO:0001754)5.98381444
22photoreceptor cell differentiation (GO:0046530)5.98381444
23retinal metabolic process (GO:0042574)5.96579735
24* cellular response to electrical stimulus (GO:0071257)5.91349137
25positive regulation of cGMP biosynthetic process (GO:0030828)5.87029619
26* retina development in camera-type eye (GO:0060041)5.86901001
27fat-soluble vitamin metabolic process (GO:0006775)5.85719561
28regulation of cGMP biosynthetic process (GO:0030826)5.56456476
29negative regulation of cardiac muscle tissue development (GO:0055026)5.53626349
30retinol metabolic process (GO:0042572)5.18002529
31positive regulation of cGMP metabolic process (GO:0030825)5.16097718
32receptor guanylyl cyclase signaling pathway (GO:0007168)5.12274817
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.97679764
34cell morphogenesis involved in neuron differentiation (GO:0048667)4.81922994
35* cellular response to radiation (GO:0071478)4.81320304
36positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.66833160
37regulation of cardiac muscle cell differentiation (GO:2000725)4.55173079
38nonmotile primary cilium assembly (GO:0035058)4.25629665
39isoprenoid metabolic process (GO:0006720)4.22508900
40keratan sulfate catabolic process (GO:0042340)4.11345354
41prenylation (GO:0097354)4.03370133
42protein prenylation (GO:0018342)4.03370133
43negative regulation of striated muscle cell differentiation (GO:0051154)3.95805805
44short-term memory (GO:0007614)3.93390776
45regulation of voltage-gated calcium channel activity (GO:1901385)3.78641617
46retina homeostasis (GO:0001895)3.73824571
47* regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)3.69059808
48regulation of cardiac muscle hypertrophy (GO:0010611)3.66141550
49* sensory perception (GO:0007600)3.63567782
50nucleoside diphosphate catabolic process (GO:0009134)3.61461145
51* response to light stimulus (GO:0009416)3.53621194
52regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.52977608
53regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.52977608
54regulation of muscle hypertrophy (GO:0014743)3.51510312
55positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.48984071
56regulation of penile erection (GO:0060405)3.46753144
57adaptation of signaling pathway (GO:0023058)3.42491614
58rRNA modification (GO:0000154)3.39282110
59behavioral response to ethanol (GO:0048149)3.38455557
60chemosensory behavior (GO:0007635)3.36160831
61peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.29727614
62negative regulation of organ growth (GO:0046621)3.29379006
63maturation of SSU-rRNA (GO:0030490)3.25333608
64ribosomal small subunit biogenesis (GO:0042274)3.14055351
65estrogen biosynthetic process (GO:0006703)3.13452473
66positive regulation of cyclase activity (GO:0031281)3.13220857
67response to histamine (GO:0034776)3.08908938
68regulation of clathrin-mediated endocytosis (GO:2000369)3.06019801
69vitamin A metabolic process (GO:0006776)23.6595003
70positive regulation of sodium ion transmembrane transport (GO:1902307)2.98922296
71cellular response to zinc ion (GO:0071294)2.96193253
72viral transcription (GO:0019083)2.95852450
73positive regulation of lyase activity (GO:0051349)2.93814720
74primary alcohol metabolic process (GO:0034308)2.92519701
75arachidonic acid secretion (GO:0050482)2.91551698
76icosanoid secretion (GO:0032309)2.91551698
77positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.88660852
78translational termination (GO:0006415)2.88547379
79rRNA methylation (GO:0031167)2.88430604
80protein heterotetramerization (GO:0051290)2.88007496
81membrane hyperpolarization (GO:0060081)2.83261969
82* neuron development (GO:0048666)2.82910619
83* detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.82599802
84retina layer formation (GO:0010842)2.81897848
85post-embryonic morphogenesis (GO:0009886)2.80699349
86regulation of muscle adaptation (GO:0043502)2.80094056
87regulation of cytokine production involved in inflammatory response (GO:1900015)2.77832333
88CDP-diacylglycerol biosynthetic process (GO:0016024)2.77070531
89regulation of dopamine metabolic process (GO:0042053)2.76607659
90regulation of catecholamine metabolic process (GO:0042069)2.76607659
91positive regulation of neurotransmitter transport (GO:0051590)2.76133003
92negative regulation of striated muscle tissue development (GO:0045843)2.74945885
93low-density lipoprotein particle remodeling (GO:0034374)2.73777268
94positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.71682450
95positive regulation of ERBB signaling pathway (GO:1901186)2.69746987
96retinoid metabolic process (GO:0001523)2.66284583
97negative regulation of muscle tissue development (GO:1901862)2.64612477
98positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.64147179
99CDP-diacylglycerol metabolic process (GO:0046341)2.63091009
100spliceosomal complex assembly (GO:0000245)2.62330603
101synaptic transmission, dopaminergic (GO:0001963)2.60105563
102positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.58406319
103negative regulation of muscle organ development (GO:0048635)2.58376788
104* response to radiation (GO:0009314)2.54474525
105complement activation, alternative pathway (GO:0006957)2.54384256
106protein localization to synapse (GO:0035418)2.54321328
107vasculature development (GO:0001944)2.52021252
108negative regulation of catenin import into nucleus (GO:0035414)2.51943072
109negative regulation of complement activation (GO:0045916)2.50719433
110quaternary ammonium group transport (GO:0015697)2.50643298
111negative regulation of receptor-mediated endocytosis (GO:0048261)2.49061483
112preassembly of GPI anchor in ER membrane (GO:0016254)2.48843950
113behavioral response to cocaine (GO:0048148)2.48365333
114histone H4-K8 acetylation (GO:0043982)2.47254305
115histone H4-K5 acetylation (GO:0043981)2.47254305
116positive regulation of respiratory burst (GO:0060267)2.46552932
117diterpenoid metabolic process (GO:0016101)2.46162489
118spliceosomal snRNP assembly (GO:0000387)2.43798404
119cell migration involved in gastrulation (GO:0042074)2.43324015
120base-excision repair, AP site formation (GO:0006285)2.41180213
121negative regulation of cation channel activity (GO:2001258)2.40798376
122terpenoid metabolic process (GO:0006721)2.40328181
123regulation of lipoprotein metabolic process (GO:0050746)2.39651597
124negative regulation of calcium ion transmembrane transport (GO:1903170)2.38023251
125negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.38023251
126regulation of short-term neuronal synaptic plasticity (GO:0048172)2.37420549
127negative regulation of protein activation cascade (GO:2000258)2.35876449
128DNA deamination (GO:0045006)2.35167748
129regulation of cardiac muscle tissue growth (GO:0055021)2.28846342
130modified amino acid transport (GO:0072337)2.27028039
131* response to electrical stimulus (GO:0051602)2.25631068
132phospholipid translocation (GO:0045332)2.19245367
133lipid translocation (GO:0034204)2.19245367
134cellular response to cadmium ion (GO:0071276)2.18366574
135regulation of complement activation (GO:0030449)2.18173821
136fat-soluble vitamin biosynthetic process (GO:0042362)2.14432419
137cell-cell junction maintenance (GO:0045217)2.11139604
138regulation of protein activation cascade (GO:2000257)2.10687980
139barbed-end actin filament capping (GO:0051016)2.09489719
140* cellular response to abiotic stimulus (GO:0071214)2.08750699
141gamma-aminobutyric acid transport (GO:0015812)2.08015258
142negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.07641645
143extracellular fibril organization (GO:0043206)2.07625160
144regulation of cyclase activity (GO:0031279)2.07007068
145lymphangiogenesis (GO:0001946)2.06812712
146smooth muscle tissue development (GO:0048745)2.04677755
147negative regulation of muscle cell differentiation (GO:0051148)2.02723015
148sodium-independent organic anion transport (GO:0043252)2.02573083
149embryonic heart tube development (GO:0035050)2.00779146
150* regulation of rhodopsin mediated signaling pathway (GO:0022400)17.5546719
151* rhodopsin mediated signaling pathway (GO:0016056)17.0656381
152retinal cone cell development (GO:0046549)15.0572367
153* photoreceptor cell development (GO:0042461)10.6510555
154photoreceptor cell maintenance (GO:0045494)10.5240314
155positive regulation of guanylate cyclase activity (GO:0031284)10.1134736
156* eye photoreceptor cell development (GO:0042462)10.1048253
157muscle filament sliding (GO:0030049)1.98877569
158actin-myosin filament sliding (GO:0033275)1.98877569

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse4.10402085
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.75561747
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.61825554
4VDR_22108803_ChIP-Seq_LS180_Human3.36028681
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.30254480
6NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.27210964
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.15467287
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.13401548
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.13221384
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.99132367
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.81748452
12DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.78291926
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69370150
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.69031322
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.66033721
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.61411420
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.53620050
18BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.51444827
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.46128292
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.43479874
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.43046697
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.40105271
23XRN2_22483619_ChIP-Seq_HELA_Human2.38099976
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.33735052
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.25929388
26NANOG_18555785_ChIP-Seq_MESCs_Mouse2.25886025
27CREB1_15753290_ChIP-ChIP_HEK293T_Human2.21709920
28ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.19211287
29MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17862315
30EP300_21415370_ChIP-Seq_HL-1_Mouse2.13203783
31CDX2_19796622_ChIP-Seq_MESCs_Mouse2.12883635
32POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.12063833
33ESR2_21235772_ChIP-Seq_MCF-7_Human2.10667670
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.06225102
35RARG_19884340_ChIP-ChIP_MEFs_Mouse2.06120338
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89954793
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.88305836
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.87197319
39SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.82551677
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78653511
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76603622
42NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.73501337
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.71554457
44ELK1_22589737_ChIP-Seq_MCF10A_Human1.71249716
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.71098126
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.70806447
47TTF2_22483619_ChIP-Seq_HELA_Human1.69450624
48FOXP3_21729870_ChIP-Seq_TREG_Human1.65131763
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.64134879
50CJUN_26792858_Chip-Seq_BT549_Human1.63625084
51PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.62913617
52FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.60767765
53VDR_23849224_ChIP-Seq_CD4+_Human1.60638818
54TBX20_22328084_ChIP-Seq_HEART_Mouse1.59763169
55TBX20_22080862_ChIP-Seq_HEART_Mouse1.59763169
56FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.59682168
57* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.59315513
58SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.57244842
59TRIM28_21343339_ChIP-Seq_HEK293_Human1.53941418
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.53263364
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.52737516
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52433779
63RXR_22158963_ChIP-Seq_LIVER_Mouse1.52072467
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50438330
65SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.50067893
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48373751
67NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48272342
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47982497
69KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.47855486
70KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.47855486
71KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.47855486
72* EZH2_27294783_Chip-Seq_ESCs_Mouse1.47816567
73SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.47271922
74BP1_19119308_ChIP-ChIP_Hs578T_Human1.45417607
75* GATA1_26923725_Chip-Seq_HPCs_Mouse1.45412896
76FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.41848682
77ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.41716204
78* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.41662510
79DCP1A_22483619_ChIP-Seq_HELA_Human1.40857578
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40756071
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.40516166
82* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.37640678
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36967570
84AHR_22903824_ChIP-Seq_MCF-7_Human1.36765528
85IGF1R_20145208_ChIP-Seq_DFB_Human1.36163540
86RXRA_24833708_ChIP-Seq_LIVER_Mouse1.35005921
87SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33099607
88YY1_22570637_ChIP-Seq_MALME-3M_Human1.32664920
89AR_21572438_ChIP-Seq_LNCaP_Human1.32414686
90NANOG_21062744_ChIP-ChIP_HESCs_Human1.32367215
91MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31670654
92* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.31649684
93* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.31586759
94SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31573034
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31511033
96EED_16625203_ChIP-ChIP_MESCs_Mouse1.31196772
97PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.30996119
98EGR1_23403033_ChIP-Seq_LIVER_Mouse1.30751838
99SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.30133028
100GATA2_21666600_ChIP-Seq_HMVEC_Human1.29221730
101DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28388763
102FOXM1_23109430_ChIP-Seq_U2OS_Human1.27659202
103ISL1_27105846_Chip-Seq_CPCs_Mouse1.27571215
104LXR_22158963_ChIP-Seq_LIVER_Mouse1.27422816
105CTCF_27219007_Chip-Seq_Bcells_Human1.26128722
106CTCF_20526341_ChIP-Seq_ESCs_Human1.25938321
107SOX2_18692474_ChIP-Seq_MEFs_Mouse1.25838817
108* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25737178
109GABP_19822575_ChIP-Seq_HepG2_Human1.25239892
110CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25128755
111NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.24731857
112EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24288273
113CBX2_27304074_Chip-Seq_ESCs_Mouse1.24180424
114GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22874974
115E2F7_22180533_ChIP-Seq_HELA_Human1.22305892
116ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21438805
117GATA1_22025678_ChIP-Seq_K562_Human1.20757981
118SMAD_19615063_ChIP-ChIP_OVARY_Human1.19723710
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19417840
120CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.19392550
121EGR1_19032775_ChIP-ChIP_M12_Human1.18830083
122STAT1_17558387_ChIP-Seq_HELA_Human1.18744289
123LXR_22292898_ChIP-Seq_THP-1_Human1.16937802
124MYC_18940864_ChIP-ChIP_HL60_Human1.16740227
125ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16701642
126MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16048376
127* KAP1_27257070_Chip-Seq_ESCs_Mouse1.15503685
128ELK1_19687146_ChIP-ChIP_HELA_Human1.14586486
129NANOG_16153702_ChIP-ChIP_HESCs_Human1.13876149
130FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.13823067
131SRF_21415370_ChIP-Seq_HL-1_Mouse1.13704295
132EZH2_18974828_ChIP-Seq_MESCs_Mouse1.13612630
133RNF2_18974828_ChIP-Seq_MESCs_Mouse1.13612630
134ERG_21242973_ChIP-ChIP_JURKAT_Human1.12813815
135BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12669798
136NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12344280
137NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10670583
138P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09939342
139IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08281802
140* GF1_26923725_Chip-Seq_HPCs_Mouse1.08184831
141GATA1_19941827_ChIP-Seq_MEL_Mouse1.08122230
142UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07584564
143* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.07557068
144YY1_21170310_ChIP-Seq_MESCs_Mouse1.07154676
145NCOR_22424771_ChIP-Seq_293T_Human1.06898907
146SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06200318
147P68_20966046_ChIP-Seq_HELA_Human1.05994063
148KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03965838
149SA1_27219007_Chip-Seq_Bcells_Human1.03696782
150CTCF_18555785_ChIP-Seq_MESCs_Mouse1.03480071
151ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03413568
152CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02511471
153KDM2B_26808549_Chip-Seq_REH_Human1.02364244
154PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01554317
155GBX2_23144817_ChIP-Seq_PC3_Human1.01542298
156NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01270522
157CBP_21632823_ChIP-Seq_H3396_Human1.01019964
158CIITA_25753668_ChIP-Seq_RAJI_Human1.00765292
159* RING1B_27294783_Chip-Seq_ESCs_Mouse1.00622499
160KDM5A_27292631_Chip-Seq_BREAST_Human1.00098047
161NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99136696
162WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98721066
163SMC4_20622854_ChIP-Seq_HELA_Human0.97657347
164RXR_22108803_ChIP-Seq_LS180_Human0.97477457
165TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96983883
166TP63_17297297_ChIP-ChIP_HaCaT_Human0.96975994
167SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95548439
168TAF2_19829295_ChIP-Seq_ESCs_Human0.93753320
169JARID2_20064375_ChIP-Seq_MESCs_Mouse0.93618092
170TCF4_18268006_ChIP-ChIP_LS174T_Human0.93532261
171PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93443729
172* TAL1_26923725_Chip-Seq_HPCs_Mouse0.92626446
173E2F1_20622854_ChIP-Seq_HELA_Human0.91424154
174* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90886698
175CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90825624
176DROSHA_22980978_ChIP-Seq_HELA_Human0.90679656
177SOX2_16153702_ChIP-ChIP_HESCs_Human0.90561498
178GF1B_26923725_Chip-Seq_HPCs_Mouse0.90338451
179* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.89999822
180MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89690649
181SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.89374117
182EOMES_21245162_ChIP-Seq_HESCs_Human0.89025181
183SMAD4_21799915_ChIP-Seq_A2780_Human0.88591729
184MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.87933751
185SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87112539
186KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.86904271
187SMAD3_21741376_ChIP-Seq_HESCs_Human0.86434041
188E2F1_17053090_ChIP-ChIP_MCF-7_Human0.86229517
189CLOCK_20551151_ChIP-Seq_293T_Human0.85743864
190PIAS1_25552417_ChIP-Seq_VCAP_Human0.85073511
191MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.84982557
192FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84617386
193LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84062109
194SCL_19346495_ChIP-Seq_HPC-7_Human0.84010405
195EZH2_27304074_Chip-Seq_ESCs_Mouse0.83918611
196SMAD3_21741376_ChIP-Seq_EPCs_Human0.83391973
197MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.82903679

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog9.30499444
2* MP0005253_abnormal_eye_physiology6.51847972
3MP0006072_abnormal_retinal_apoptosis6.39481293
4MP0003950_abnormal_plasma_membrane4.59546104
5* MP0005195_abnormal_posterior_eye3.63959560
6MP0001324_abnormal_eye_pigmentation3.28303327
7* MP0005391_vision/eye_phenotype3.19467984
8MP0002638_abnormal_pupillary_reflex2.93742741
9MP0002090_abnormal_vision2.87233033
10MP0004145_abnormal_muscle_electrophysio2.38621361
11* MP0002229_neurodegeneration2.33743743
12MP0001764_abnormal_homeostasis2.08057239
13MP0003011_delayed_dark_adaptation11.0684867
14* MP0002752_abnormal_somatic_nervous1.86157195
15MP0004019_abnormal_vitamin_homeostasis1.58107036
16MP0009379_abnormal_foot_pigmentation1.54570832
17MP0006292_abnormal_olfactory_placode1.52329976
18MP0002653_abnormal_ependyma_morphology1.41132892
19MP0003045_fibrosis1.36550762
20* MP0002882_abnormal_neuron_morphology1.23316316
21MP0005171_absent_coat_pigmentation1.05011169
22MP0002332_abnormal_exercise_endurance0.98409795
23MP0005499_abnormal_olfactory_system0.95035772
24MP0005394_taste/olfaction_phenotype0.95035772
25MP0002127_abnormal_cardiovascular_syste0.94860683
26MP0010368_abnormal_lymphatic_system0.93856731
27MP0008058_abnormal_DNA_repair0.91735136
28MP0001879_abnormal_lymphatic_vessel0.89700915
29MP0008789_abnormal_olfactory_epithelium0.88611551
30MP0001984_abnormal_olfaction0.87920247
31MP0003806_abnormal_nucleotide_metabolis0.87252075
32MP0005197_abnormal_uvea_morphology0.86502793
33MP0004133_heterotaxia0.85895562
34MP0005187_abnormal_penis_morphology0.85620311
35MP0005275_abnormal_skin_tensile0.81836345
36MP0004233_abnormal_muscle_weight0.77381723
37MP0004885_abnormal_endolymph0.76967434
38MP0005248_abnormal_Harderian_gland0.76747634
39MP0000566_synostosis0.74879709
40MP0002272_abnormal_nervous_system0.73183155
41MP0001286_abnormal_eye_development0.72000815
42MP0004270_analgesia0.70669964
43MP0003111_abnormal_nucleus_morphology0.68806526
44MP0003693_abnormal_embryo_hatching0.68666375
45MP0003634_abnormal_glial_cell0.68107063
46MP0002822_catalepsy0.67282764
47MP0002168_other_aberrant_phenotype0.64586264
48MP0003890_abnormal_embryonic-extraembry0.62398202
49MP0002933_joint_inflammation0.60627278
50MP0001661_extended_life_span0.59575528
51MP0005503_abnormal_tendon_morphology0.59074505
52MP0005376_homeostasis/metabolism_phenot0.58359331
53* MP0005423_abnormal_somatic_nervous0.58037157
54MP0004142_abnormal_muscle_tone0.56520068
55MP0001486_abnormal_startle_reflex0.56440630
56MP0004957_abnormal_blastocyst_morpholog0.56254297
57MP0002734_abnormal_mechanical_nocicepti0.55528561
58MP0001346_abnormal_lacrimal_gland0.53647439
59MP0005395_other_phenotype0.53162114
60MP0008438_abnormal_cutaneous_collagen0.52775272
61MP0008007_abnormal_cellular_replicative0.51828783
62MP0003136_yellow_coat_color0.50274212
63MP0001502_abnormal_circadian_rhythm0.47646323
64MP0003880_abnormal_central_pattern0.45816860
65MP0005266_abnormal_metabolism0.44007414
66MP0003724_increased_susceptibility_to0.43466605
67MP0003638_abnormal_response/metabolism_0.42681012
68MP0008057_abnormal_DNA_replication0.42610795
69MP0005167_abnormal_blood-brain_barrier0.41786371
70MP0003077_abnormal_cell_cycle0.41665062
71MP0003283_abnormal_digestive_organ0.41318299
72MP0002249_abnormal_larynx_morphology0.39704364
73MP0009046_muscle_twitch0.39408196
74MP0006035_abnormal_mitochondrial_morpho0.36814547
75MP0002075_abnormal_coat/hair_pigmentati0.36727283
76MP0001963_abnormal_hearing_physiology0.36310232
77MP0003718_maternal_effect0.35698621
78MP0005409_darkened_coat_color0.35696694
79MP0003878_abnormal_ear_physiology0.34831452
80MP0005377_hearing/vestibular/ear_phenot0.34831452
81MP0002064_seizures0.33672919
82MP0000372_irregular_coat_pigmentation0.32408580
83MP0005623_abnormal_meninges_morphology0.31293299
84MP0003646_muscle_fatigue0.30879095
85MP0003635_abnormal_synaptic_transmissio0.30815479
86MP0005257_abnormal_intraocular_pressure0.29825991
87MP0002697_abnormal_eye_size0.28783678
88MP0005620_abnormal_muscle_contractility0.28605418
89MP0000465_gastrointestinal_hemorrhage0.28443703
90MP0000751_myopathy0.28435500
91MP0006054_spinal_hemorrhage0.28006888
92MP0001968_abnormal_touch/_nociception0.27141028
93MP0002877_abnormal_melanocyte_morpholog0.26626027
94MP0000750_abnormal_muscle_regeneration0.26286243
95MP0006138_congestive_heart_failure0.26214062
96MP0002295_abnormal_pulmonary_circulatio0.25825443
97MP0003075_altered_response_to0.25665871
98MP0001905_abnormal_dopamine_level0.25401231
99MP0004036_abnormal_muscle_relaxation0.25322671
100MP0005508_abnormal_skeleton_morphology0.25246990
101MP0004085_abnormal_heartbeat0.24739663
102MP0005076_abnormal_cell_differentiation0.24736069
103MP0004272_abnormal_basement_membrane0.24652758
104MP0005595_abnormal_vascular_smooth0.24087262
105MP0002572_abnormal_emotion/affect_behav0.23907955
106MP0005165_increased_susceptibility_to0.23515337
107MP0010030_abnormal_orbit_morphology0.23159125
108MP0001186_pigmentation_phenotype0.22611525
109MP0002009_preneoplasia0.22333871
110MP0002092_abnormal_eye_morphology0.22192078
111MP0000747_muscle_weakness0.22108605
112MP0005193_abnormal_anterior_eye0.20925719
113MP0010329_abnormal_lipoprotein_level0.20485170
114MP0004859_abnormal_synaptic_plasticity0.20373011
115MP0005174_abnormal_tail_pigmentation0.20233194
116MP0000026_abnormal_inner_ear0.19706835
117MP0001730_embryonic_growth_arrest0.19480134
118MP0003941_abnormal_skin_development0.18979239
119MP0000631_abnormal_neuroendocrine_gland0.18784419
120MP0008932_abnormal_embryonic_tissue0.18625143
121MP0002067_abnormal_sensory_capabilities0.18544125
122MP0002085_abnormal_embryonic_tissue0.18510697
123MP0009745_abnormal_behavioral_response0.18466048
124MP0003633_abnormal_nervous_system0.18180151
125MP0000350_abnormal_cell_proliferation0.17886629
126MP0004043_abnormal_pH_regulation0.17814396
127MP0003300_gastrointestinal_ulcer0.17653307
128MP0002184_abnormal_innervation0.16863929
129MP0002152_abnormal_brain_morphology0.16490984
130MP0008004_abnormal_stomach_pH0.16275427
131MP0008775_abnormal_heart_ventricle0.15438874
132MP0009764_decreased_sensitivity_to0.15097426
133MP0000767_abnormal_smooth_muscle0.14913047
134MP0001915_intracranial_hemorrhage0.14632540
135MP0009703_decreased_birth_body0.14580277
136MP0004381_abnormal_hair_follicle0.14530990
137MP0005386_behavior/neurological_phenoty0.14465112
138MP0004924_abnormal_behavior0.14465112
139MP0003698_abnormal_male_reproductive0.14452968
140MP0001958_emphysema0.14376151
141MP0000013_abnormal_adipose_tissue0.14221687
142MP0000462_abnormal_digestive_system0.14051290
143MP0002102_abnormal_ear_morphology0.13963154
144* MP0000001_mammalian_phenotype0.13701682
145MP0005367_renal/urinary_system_phenotyp0.13432607
146MP0000516_abnormal_urinary_system0.13432607
147MP0002108_abnormal_muscle_morphology0.12957868
148MP0004084_abnormal_cardiac_muscle0.12765130
149MP0000249_abnormal_blood_vessel0.12442112
150MP0005023_abnormal_wound_healing0.12242662
151MP0001851_eye_inflammation0.11651180
152MP0001756_abnormal_urination0.11178723
153MP0005410_abnormal_fertilization0.10744856
154MP0000163_abnormal_cartilage_morphology0.10469680
155MP0000749_muscle_degeneration0.09513880
156MP0000920_abnormal_myelination0.09091294
157MP0002128_abnormal_blood_circulation0.09077108
158MP0002971_abnormal_brown_adipose0.08458585
159MP0003879_abnormal_hair_cell0.08444406
160MP0002282_abnormal_trachea_morphology0.08393586
161MP0000534_abnormal_ureter_morphology0.08373572
162MP0005365_abnormal_bile_salt0.08103113
163MP0003631_nervous_system_phenotype0.07544537
164MP0002938_white_spotting0.07161777
165MP0001614_abnormal_blood_vessel0.07069073
166MP0000569_abnormal_digit_pigmentation0.06765145
167MP0005390_skeleton_phenotype0.05401164

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)9.94897797
2Pigmentary retinal degeneration (HP:0001146)9.63127476
3Abnormal rod and cone electroretinograms (HP:0008323)9.60546054
4Pendular nystagmus (HP:0012043)8.03781962
5Dyschromatopsia (HP:0007641)7.90707865
6Central scotoma (HP:0000603)7.74972914
7Attenuation of retinal blood vessels (HP:0007843)7.67917742
8Chorioretinal atrophy (HP:0000533)7.57542002
9Abnormality of macular pigmentation (HP:0008002)7.09581496
10Scotoma (HP:0000575)6.86428637
11Decreased central vision (HP:0007663)6.36043480
12Abolished electroretinogram (ERG) (HP:0000550)5.50621736
13Photophobia (HP:0000613)5.39608650
14Type II diabetes mellitus (HP:0005978)5.38565787
15Macular degeneration (HP:0000608)4.76909341
16Increased corneal curvature (HP:0100692)4.57414085
17Keratoconus (HP:0000563)4.57414085
18Vitreoretinal degeneration (HP:0000655)4.42193385
19Severe visual impairment (HP:0001141)4.32845526
20Choroideremia (HP:0001139)4.30962194
21Retinitis pigmentosa (HP:0000510)4.13098784
22Cone-rod dystrophy (HP:0000548)3.99286942
23Posterior subcapsular cataract (HP:0007787)3.85064970
24Constricted visual fields (HP:0001133)3.76937752
25Decreased electroretinogram (ERG) amplitude (HP:0000654)3.51389629
26Long foot (HP:0001833)3.25472186
27Duplicated collecting system (HP:0000081)3.19316030
28Optic disc pallor (HP:0000543)3.10015247
29Ulnar claw (HP:0001178)2.99447435
30Systemic lupus erythematosus (HP:0002725)2.99400699
31Complement deficiency (HP:0004431)2.84301784
32Subcapsular cataract (HP:0000523)2.78043165
33Acute lymphatic leukemia (HP:0006721)2.69740077
34Abnormality of the renal collecting system (HP:0004742)2.68440167
35Progressive visual loss (HP:0000529)2.64784373
36Hypoplastic nipples (HP:0002557)2.61345241
37Wide nasal bridge (HP:0000431)2.44380398
38Retinal atrophy (HP:0001105)2.40380810
39Abnormality of complement system (HP:0005339)2.34914979
40Segmental peripheral demyelination/remyelination (HP:0003481)2.32448664
41Action tremor (HP:0002345)2.23359464
42Gait imbalance (HP:0002141)2.19492252
43Abnormal pupillary function (HP:0007686)2.18640910
44Congenital primary aphakia (HP:0007707)2.18076808
45Hypopigmentation of the fundus (HP:0007894)2.17661023
46Insidious onset (HP:0003587)2.14070728
47Termporal pattern (HP:0011008)2.14070728
48Congenital sensorineural hearing impairment (HP:0008527)2.08659659
49Broad-based gait (HP:0002136)2.05748332
50* Congenital stationary night blindness (HP:0007642)15.8510744
51Bony spicule pigmentary retinopathy (HP:0007737)11.0558229
52Peripheral hypomyelination (HP:0007182)1.96682230
53Large for gestational age (HP:0001520)1.93428123
54Nephrogenic diabetes insipidus (HP:0009806)1.88103322
55Medial flaring of the eyebrow (HP:0010747)1.86348899
56Adactyly (HP:0009776)1.85067247
57Glomerulonephritis (HP:0000099)1.81390627
58Pulmonary artery stenosis (HP:0004415)1.79670579
59Horizontal nystagmus (HP:0000666)1.77134711
60White forelock (HP:0002211)1.74887028
61Hypoplasia of the iris (HP:0007676)1.72516625
62Amyloidosis (HP:0011034)1.69652706
63Poor coordination (HP:0002370)1.64777079
64Upper limb muscle weakness (HP:0003484)1.62324802
65Optic atrophy (HP:0000648)1.62211328
66Annular pancreas (HP:0001734)1.59737728
67True hermaphroditism (HP:0010459)1.56468645
68Patchy hypopigmentation of hair (HP:0011365)1.49802053
69Breast hypoplasia (HP:0003187)1.49746013
70Ureteral duplication (HP:0000073)1.47783659
71Hemorrhage of the eye (HP:0011885)1.46877024
72Vaginal atresia (HP:0000148)1.45530766
73Increased CSF protein (HP:0002922)1.45326492
74Ureteral stenosis (HP:0000071)1.45221929
75Polar cataract (HP:0010696)1.44714825
76Nemaline bodies (HP:0003798)1.40902256
77Abnormal ventriculo-arterial connection (HP:0011563)1.38070714
78Transposition of the great arteries (HP:0001669)1.38070714
79Abnormal connection of the cardiac segments (HP:0011545)1.38070714
80Decreased activity of mitochondrial respiratory chain (HP:0008972)1.37052687
81Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.37052687
82Genital tract atresia (HP:0001827)1.37051782
83Nephritis (HP:0000123)1.35146482
84Impaired proprioception (HP:0010831)1.34689604
85Muscle fiber inclusion bodies (HP:0100299)1.34219983
86Progressive sensorineural hearing impairment (HP:0000408)1.33053469
87Thyroiditis (HP:0100646)1.32510387
88Pallor (HP:0000980)1.28935058
89Ureteral obstruction (HP:0006000)1.27805894
90Foot dorsiflexor weakness (HP:0009027)1.27554598
91Cystic liver disease (HP:0006706)1.27022764
92Calf muscle hypertrophy (HP:0008981)1.25662144
93Increased intramyocellular lipid droplets (HP:0012240)1.25117394
94Progressive external ophthalmoplegia (HP:0000590)1.24541532
95Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.24438161
96Interstitial pulmonary disease (HP:0006530)1.23518806
97Protrusio acetabuli (HP:0003179)1.21376634
98Distal lower limb amyotrophy (HP:0008944)1.21171062
99Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.20611251
100Pancreatic fibrosis (HP:0100732)1.19523550
101Abnormality of the foot musculature (HP:0001436)1.18104629
102Aplasia/Hypoplasia of the lens (HP:0008063)1.17597936
103Chorioretinal coloboma (HP:0000567)1.17097727
104Postural tremor (HP:0002174)1.16861144
105Aplasia/Hypoplasia of the nipples (HP:0006709)1.14907743
106Muscle fiber splitting (HP:0003555)1.14142061
107Distal arthrogryposis (HP:0005684)1.13087884
108Pancreatic cysts (HP:0001737)1.12935135
109Aplasia/Hypoplasia of the fovea (HP:0008060)1.12796576
110Hypoplasia of the fovea (HP:0007750)1.12796576
111Abnormality of abdominal situs (HP:0011620)1.12690132
112Abdominal situs inversus (HP:0003363)1.12690132
113Difficulty running (HP:0009046)1.12491110
114Retinal detachment (HP:0000541)1.12250417
115Joint hemorrhage (HP:0005261)1.11807663
116Steppage gait (HP:0003376)1.11224783
117Aortic aneurysm (HP:0004942)1.10766016
118Distal lower limb muscle weakness (HP:0009053)1.10667441
119Severe Myopia (HP:0011003)1.10081284
120Deep venous thrombosis (HP:0002625)1.09898420
121Reticulocytopenia (HP:0001896)1.08472754
122Muscle hypertrophy of the lower extremities (HP:0008968)1.08007814
123Vertebral compression fractures (HP:0002953)1.07947291
124Blue irides (HP:0000635)1.06473873
125Abnormality of the fovea (HP:0000493)1.05945890
126Abnormality of cells of the erythroid lineage (HP:0012130)1.02128910
127Type 1 muscle fiber predominance (HP:0003803)1.01737343
128Large hands (HP:0001176)1.01538813
129Macrocytic anemia (HP:0001972)1.00710299
130Dysdiadochokinesis (HP:0002075)0.99058273
131Astigmatism (HP:0000483)0.98571603
132Increased muscle lipid content (HP:0009058)0.96973285
133Onion bulb formation (HP:0003383)0.95660917
134Colon cancer (HP:0003003)0.94886077
135Widely spaced teeth (HP:0000687)0.94515725
136Abnormal number of erythroid precursors (HP:0012131)0.93523528
137Bicornuate uterus (HP:0000813)0.93499979
138Decreased testicular size (HP:0008734)0.92271338
139Stereotypic behavior (HP:0000733)0.92187623
140Asymmetry of the thorax (HP:0001555)0.91842010
141Genetic anticipation (HP:0003743)0.90412718
142Septo-optic dysplasia (HP:0100842)0.89955090
143Increased connective tissue (HP:0009025)0.89866237
144Sclerocornea (HP:0000647)0.89763383
145Bulbar palsy (HP:0001283)0.88994407
146Rhabdomyolysis (HP:0003201)0.88864608
147Spontaneous abortion (HP:0005268)0.88116997
148Broad foot (HP:0001769)0.88010177
149Biconcave vertebral bodies (HP:0004586)0.86399683
150Lower limb amyotrophy (HP:0007210)0.86320487
151Corneal dystrophy (HP:0001131)0.85884983
152Decreased number of peripheral myelinated nerve fibers (HP:0003380)0.85637395
153Sex reversal (HP:0012245)0.85252261
154Abnormal sex determination (HP:0012244)0.85252261
155Myoglobinuria (HP:0002913)0.85231521
156Increased number of teeth (HP:0011069)0.84982929
157Abnormality of the pupil (HP:0000615)0.83552656
158Cerebral hypomyelination (HP:0006808)0.83549844
159Ulnar deviation of the wrist (HP:0003049)0.82951438
160Colitis (HP:0002583)0.82573365
161Peripheral demyelination (HP:0011096)0.81653220

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK19.52763625
2PBK6.69549032
3TTN3.15144378
4CDC42BPA3.07752127
5IRAK22.96981004
6MARK12.75781984
7NEK12.58373352
8CCNB12.52771136
9BUB12.22540790
10TTK2.19021775
11OBSCN2.00452583
12RPS6KB21.77776223
13PNCK1.73360561
14ERN11.70142025
15IRAK31.66991325
16TGFBR21.63333029
17ADRBK11.49563187
18MAPK71.38981730
19NEK21.32288827
20EPHA31.30000919
21ZAK1.26017451
22WEE11.25278597
23PINK11.21994127
24AKT31.21830776
25INSRR1.21164679
26EPHA21.20299634
27RPS6KA41.17476935
28BRD41.17016083
29STK161.14136195
30PLK31.07635277
31PRKCZ1.07625865
32TRPM71.02045354
33ROCK21.00283898
34NEK61.00113853
35IRAK10.97452689
36PLK40.95691229
37STK380.93512418
38VRK10.91602281
39CSNK1D0.91043006
40ICK0.90884694
41PLK10.88649719
42CHEK20.87025041
43NME10.86727167
44PAK40.82409527
45WNK40.81929555
46EPHB10.81561053
47PRKCI0.80146335
48TIE10.80115935
49ATR0.79864624
50DYRK30.79369340
51PTK2B0.79322682
52SRPK10.79268738
53MAP3K100.78883006
54MAPK120.75177639
55NME20.74739809
56STK390.71875097
57CHEK10.70623911
58CDK30.70077135
59WNK10.69440955
60CSK0.67391927
61PRKCB0.67123610
62PRKD20.67110118
63ROCK10.66364766
64CDK120.65881329
65MYLK0.65794590
66EPHB20.62477200
67DDR20.60029591
68ABL20.59752381
69JAK10.59143695
70CDK70.58582482
71AURKA0.58435660
72PAK60.58432808
73EIF2AK10.58381554
74ERBB20.57595179
75PIK3CG0.57241567
76TAOK30.56082007
77SIK20.54898255
78RPS6KA50.54238200
79CAMK2D0.52572047
80CSNK1E0.52249997
81BTK0.51730659
82CDK10.50190471
83PRKDC0.49478608
84TGFBR10.48617625
85PLK20.47344030
86GRK50.46862588
87CAMK1G0.46644504
88SGK20.45717771
89MARK30.44598750
90FES0.44552684
91PRKACG0.44534983
92FGFR40.44425313
93CAMK40.44217407
94ALK0.44099762
95EIF2AK30.44078189
96PHKG20.43436123
97PHKG10.43436123
98HIPK20.42708033
99CDK20.41402421
100TESK20.40597675
101RPS6KA30.39875822
102ATM0.39502172
103CAMK10.39402864
104NLK0.38945966
105MAPK90.38934176
106CAMK1D0.38403952
107CSNK2A20.38367903
108MAPK150.36977429
109GSK3A0.36504689
110MAP3K60.36340232
111DYRK1A0.35312958
112GSK3B0.35006848
113AKT20.33860313
114PRKACA0.33346689
115CAMK2A0.32546884
116BLK0.30660772
117PRKCG0.30318669
118STK240.30170945
119PRKCA0.29934105
120MAPK140.29544178
121MAP3K30.28955956
122CSNK2A10.28511613
123KDR0.28405247
124DYRK20.27945646
125PRKAA20.26833782
126TYK20.26743404
127SGK30.26462455
128FER0.26006099
129TLK10.25759350
130PRKD10.25608201
131MKNK20.25480922
132MAPK30.24823940
133PDK20.24685220
134RIPK10.24579108
135MTOR0.24093288
136DYRK1B0.23465642
137CDK150.23291803
138CDK11A0.23154555
139SGK4940.22888235
140SGK2230.22888235
141LRRK20.21428450
142JAK20.20754482
143PRKG10.20077827
144MARK20.19888585
145MUSK0.17810781
146ZAP700.17360149
147PIK3CA0.17071228
148RET0.16544583
149MAP3K70.16470785
150STK30.16194314
151PRKCH0.15860908
152PKN20.15570336
153PDGFRA0.15477776
154HCK0.14737429
155PDPK10.14031042
156MAPK10.13320543
157PRKCD0.13214728
158MET0.12687067
159SYK0.12274417
160PRKAA10.10968746
161CHUK0.10759705
162TRIB30.09993040
163FGFR30.09868443
164PKN10.09819319
165SMG10.09094163
166MAPK40.09013845

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046102.04425392
2* Phototransduction_Homo sapiens_hsa0474415.5410887
3Ribosome_Homo sapiens_hsa030101.98011819
4RNA polymerase_Homo sapiens_hsa030201.38774621
5Synaptic vesicle cycle_Homo sapiens_hsa047211.37288123
6Staphylococcus aureus infection_Homo sapiens_hsa051501.22214160
7Purine metabolism_Homo sapiens_hsa002301.14978072
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12793805
9Spliceosome_Homo sapiens_hsa030401.09599288
10Olfactory transduction_Homo sapiens_hsa047400.97273958
11Retinol metabolism_Homo sapiens_hsa008300.97036227
12Bile secretion_Homo sapiens_hsa049760.96956088
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94958573
14Arachidonic acid metabolism_Homo sapiens_hsa005900.87943802
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86191202
16Oxidative phosphorylation_Homo sapiens_hsa001900.85871715
17Pyrimidine metabolism_Homo sapiens_hsa002400.85524963
18GABAergic synapse_Homo sapiens_hsa047270.83930655
19Mismatch repair_Homo sapiens_hsa034300.83870627
20Mineral absorption_Homo sapiens_hsa049780.83672774
21Tight junction_Homo sapiens_hsa045300.82200296
22Ether lipid metabolism_Homo sapiens_hsa005650.78562066
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78282223
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73982748
25Proteasome_Homo sapiens_hsa030500.72114723
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69587899
27Fat digestion and absorption_Homo sapiens_hsa049750.68521723
28RNA transport_Homo sapiens_hsa030130.68462018
29Huntingtons disease_Homo sapiens_hsa050160.68275835
30Nitrogen metabolism_Homo sapiens_hsa009100.66145068
31DNA replication_Homo sapiens_hsa030300.65700901
32Cardiac muscle contraction_Homo sapiens_hsa042600.65677319
33Fanconi anemia pathway_Homo sapiens_hsa034600.62605825
34Parkinsons disease_Homo sapiens_hsa050120.61056000
35Drug metabolism - other enzymes_Homo sapiens_hsa009830.60252683
36RNA degradation_Homo sapiens_hsa030180.59174549
37Nucleotide excision repair_Homo sapiens_hsa034200.58776282
38Vascular smooth muscle contraction_Homo sapiens_hsa042700.57815223
39PPAR signaling pathway_Homo sapiens_hsa033200.56854083
40Biosynthesis of amino acids_Homo sapiens_hsa012300.55309770
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54629437
42Base excision repair_Homo sapiens_hsa034100.54280455
43Malaria_Homo sapiens_hsa051440.53354904
44Fructose and mannose metabolism_Homo sapiens_hsa000510.52138268
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49251805
46Primary bile acid biosynthesis_Homo sapiens_hsa001200.47537259
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.47395107
48Cholinergic synapse_Homo sapiens_hsa047250.46853919
49Tryptophan metabolism_Homo sapiens_hsa003800.46255859
50Arginine biosynthesis_Homo sapiens_hsa002200.46200388
51Pertussis_Homo sapiens_hsa051330.45967631
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45797371
53Glutamatergic synapse_Homo sapiens_hsa047240.43893134
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43266250
55Alzheimers disease_Homo sapiens_hsa050100.43003216
56mRNA surveillance pathway_Homo sapiens_hsa030150.42529666
57Chemical carcinogenesis_Homo sapiens_hsa052040.41892398
58Morphine addiction_Homo sapiens_hsa050320.38834647
59Dopaminergic synapse_Homo sapiens_hsa047280.37955440
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37459321
61Circadian entrainment_Homo sapiens_hsa047130.36877893
62Basal transcription factors_Homo sapiens_hsa030220.36597147
63Prion diseases_Homo sapiens_hsa050200.36451904
64ABC transporters_Homo sapiens_hsa020100.36306126
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36246906
66Circadian rhythm_Homo sapiens_hsa047100.34216341
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33866595
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33740324
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.33617825
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33250206
71TGF-beta signaling pathway_Homo sapiens_hsa043500.33227422
72Folate biosynthesis_Homo sapiens_hsa007900.33021229
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32086156
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.31281273
75Histidine metabolism_Homo sapiens_hsa003400.30606581
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30225141
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30053583
78Ras signaling pathway_Homo sapiens_hsa040140.30018563
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.29780679
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.29346499
81Serotonergic synapse_Homo sapiens_hsa047260.29337322
82Non-small cell lung cancer_Homo sapiens_hsa052230.28815969
83Systemic lupus erythematosus_Homo sapiens_hsa053220.28609539
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27996853
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27413400
86Nicotine addiction_Homo sapiens_hsa050330.26439999
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.26418596
88Fatty acid degradation_Homo sapiens_hsa000710.26138614
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25565231
90Caffeine metabolism_Homo sapiens_hsa002320.24990289
91One carbon pool by folate_Homo sapiens_hsa006700.24713743
92Arginine and proline metabolism_Homo sapiens_hsa003300.24624029
93Galactose metabolism_Homo sapiens_hsa000520.24408117
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24010946
95ECM-receptor interaction_Homo sapiens_hsa045120.23588139
96FoxO signaling pathway_Homo sapiens_hsa040680.22792332
97Fatty acid elongation_Homo sapiens_hsa000620.22141646
98Homologous recombination_Homo sapiens_hsa034400.21916781
99Adherens junction_Homo sapiens_hsa045200.21882695
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21227759
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.20986871
102Insulin secretion_Homo sapiens_hsa049110.20265125
103Carbon metabolism_Homo sapiens_hsa012000.20123905
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19512455
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.18875991
106Oocyte meiosis_Homo sapiens_hsa041140.18526808
107Metabolic pathways_Homo sapiens_hsa011000.18317439
108Pancreatic secretion_Homo sapiens_hsa049720.18188067
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.16614041
110Epstein-Barr virus infection_Homo sapiens_hsa051690.16603001
111Calcium signaling pathway_Homo sapiens_hsa040200.16267402
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16168047
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.16147771
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.15529186
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.14613317
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.14118609
117Thyroid hormone synthesis_Homo sapiens_hsa049180.14097701
118Phenylalanine metabolism_Homo sapiens_hsa003600.13937619
119Cell cycle_Homo sapiens_hsa041100.13143637
120Pentose phosphate pathway_Homo sapiens_hsa000300.12739011
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.12200479
122Taste transduction_Homo sapiens_hsa047420.12145119
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.11935770
124Glycerolipid metabolism_Homo sapiens_hsa005610.11642199
125Vitamin B6 metabolism_Homo sapiens_hsa007500.11259230
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.10905853
127Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.10319763
128HIF-1 signaling pathway_Homo sapiens_hsa040660.10285027
129Pyruvate metabolism_Homo sapiens_hsa006200.10281383
130Wnt signaling pathway_Homo sapiens_hsa043100.10088075
131Ovarian steroidogenesis_Homo sapiens_hsa049130.09930766
132Focal adhesion_Homo sapiens_hsa045100.09444953
133Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.09329140
134Butanoate metabolism_Homo sapiens_hsa006500.09327514
135Vitamin digestion and absorption_Homo sapiens_hsa049770.08596740
136Collecting duct acid secretion_Homo sapiens_hsa049660.08573238
137Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.08490238
138Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.08280112
139Phospholipase D signaling pathway_Homo sapiens_hsa040720.08076430
140Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.07609915
141Cyanoamino acid metabolism_Homo sapiens_hsa004600.07505706
142Melanoma_Homo sapiens_hsa052180.07485926
143Dilated cardiomyopathy_Homo sapiens_hsa054140.07455700
144Tyrosine metabolism_Homo sapiens_hsa003500.06996196
145Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.06250228
146Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.06094008
147Oxytocin signaling pathway_Homo sapiens_hsa049210.05966859
148Alcoholism_Homo sapiens_hsa050340.04976425
149Peroxisome_Homo sapiens_hsa041460.04966247
150Proteoglycans in cancer_Homo sapiens_hsa052050.04582950
151Protein export_Homo sapiens_hsa030600.04393470
152Thyroid cancer_Homo sapiens_hsa052160.04183537
153Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.04131072
154Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.04047965
155Leukocyte transendothelial migration_Homo sapiens_hsa046700.03685355
156Chemokine signaling pathway_Homo sapiens_hsa040620.03633249
157Prostate cancer_Homo sapiens_hsa052150.03620898
158mTOR signaling pathway_Homo sapiens_hsa041500.03316909
159Aldosterone synthesis and secretion_Homo sapiens_hsa049250.03164401
160Central carbon metabolism in cancer_Homo sapiens_hsa052300.03020908
161Linoleic acid metabolism_Homo sapiens_hsa005910.02995509
162Glutathione metabolism_Homo sapiens_hsa004800.02674334
163Inositol phosphate metabolism_Homo sapiens_hsa005620.02151386

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