GNAQ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.37637608
2vocalization behavior (GO:0071625)5.05804406
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.65876345
4ionotropic glutamate receptor signaling pathway (GO:0035235)4.50460187
5neuron recognition (GO:0008038)4.49403201
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.42746221
7synaptic vesicle exocytosis (GO:0016079)4.40765978
8protein localization to synapse (GO:0035418)4.38021774
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.29852127
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.21743486
11regulation of glutamate receptor signaling pathway (GO:1900449)4.16992476
12dendritic spine morphogenesis (GO:0060997)4.11329035
13locomotory exploration behavior (GO:0035641)4.10624991
14presynaptic membrane assembly (GO:0097105)4.07714598
15* glutamate receptor signaling pathway (GO:0007215)4.04347370
16axonal fasciculation (GO:0007413)4.00608934
17nerve growth factor signaling pathway (GO:0038180)3.97639147
18exploration behavior (GO:0035640)3.90508742
19regulation of synaptic vesicle exocytosis (GO:2000300)3.86248504
20neuronal action potential propagation (GO:0019227)3.83688514
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.82606628
22presynaptic membrane organization (GO:0097090)3.82145940
23negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.76671153
24glutamate secretion (GO:0014047)3.75303835
25layer formation in cerebral cortex (GO:0021819)3.73208406
26synaptic vesicle maturation (GO:0016188)3.66004622
27gamma-aminobutyric acid signaling pathway (GO:0007214)3.64247540
28synaptic transmission, glutamatergic (GO:0035249)3.61389286
29neuron-neuron synaptic transmission (GO:0007270)3.59602813
30postsynaptic membrane organization (GO:0001941)3.58205237
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.53140916
32regulation of neuronal synaptic plasticity (GO:0048168)3.45559314
33negative regulation of synaptic transmission, GABAergic (GO:0032229)3.43353487
34negative regulation of neurotransmitter secretion (GO:0046929)3.42862004
35regulation of synaptic vesicle transport (GO:1902803)3.39012566
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.37258575
37transmission of nerve impulse (GO:0019226)3.33027380
38cell migration in hindbrain (GO:0021535)3.30431352
39regulation of dendritic spine morphogenesis (GO:0061001)3.29385999
40interkinetic nuclear migration (GO:0022027)3.28695279
41regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.28638805
42neurotransmitter secretion (GO:0007269)3.27171048
43regulation of postsynaptic membrane potential (GO:0060078)3.23114585
44dendrite morphogenesis (GO:0048813)3.20816981
45positive regulation of synapse assembly (GO:0051965)3.17928064
46regulation of vesicle fusion (GO:0031338)3.17177655
47innervation (GO:0060384)3.15058095
48long-term memory (GO:0007616)3.13442274
49regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.11821534
50negative regulation of neurotransmitter transport (GO:0051589)3.10974099
51regulation of synapse structural plasticity (GO:0051823)3.09104767
52synapse assembly (GO:0007416)3.09000583
53neurotransmitter-gated ion channel clustering (GO:0072578)3.08158412
54long-term synaptic potentiation (GO:0060291)3.07167011
55pyrimidine nucleobase catabolic process (GO:0006208)3.06388936
56dendritic spine organization (GO:0097061)3.06054283
57positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.05272597
58G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.04892715
59synaptic vesicle endocytosis (GO:0048488)3.04827396
60proline transport (GO:0015824)3.03252959
61positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.01779818
62regulation of dendritic spine development (GO:0060998)3.01538332
63regulation of synaptic transmission, glutamatergic (GO:0051966)2.99012368
64regulation of glutamate secretion (GO:0014048)2.97264534
65positive regulation of membrane potential (GO:0045838)2.96182975
66regulation of synaptic plasticity (GO:0048167)2.94657076
67neurotransmitter transport (GO:0006836)2.93821427
68gamma-aminobutyric acid transport (GO:0015812)2.92451672
69response to histamine (GO:0034776)2.92415620
70mating behavior (GO:0007617)2.91926505
71central nervous system projection neuron axonogenesis (GO:0021952)2.91162612
72startle response (GO:0001964)2.87295399
73auditory behavior (GO:0031223)2.87234793
74learning (GO:0007612)2.87107677
75membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.86387066
76membrane depolarization (GO:0051899)2.85464999
77positive regulation of dendritic spine development (GO:0060999)2.84973176
78regulation of respiratory system process (GO:0044065)2.81093985
79negative regulation of microtubule polymerization (GO:0031115)2.81010799
80cerebral cortex radially oriented cell migration (GO:0021799)2.80974627
81cell differentiation in hindbrain (GO:0021533)2.79827627
82positive regulation of synaptic transmission, GABAergic (GO:0032230)2.79168163
83regulation of neurotransmitter secretion (GO:0046928)2.78897592
84synapse organization (GO:0050808)2.78567528
85positive regulation of synapse maturation (GO:0090129)2.78154873
86cerebellar granule cell differentiation (GO:0021707)2.76435095
87nucleobase catabolic process (GO:0046113)2.76420638
88behavioral fear response (GO:0001662)2.75311893
89behavioral defense response (GO:0002209)2.75311893
90fear response (GO:0042596)2.73250371
91epithelial cell differentiation involved in kidney development (GO:0035850)2.73116991
92positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.72949871
93organelle transport along microtubule (GO:0072384)2.72768052
94cerebellar Purkinje cell differentiation (GO:0021702)2.72211713
95negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.71667591
96vesicle transport along microtubule (GO:0047496)2.71369277
97regulation of synapse assembly (GO:0051963)2.71345774
98synaptic vesicle docking involved in exocytosis (GO:0016081)2.70700567
99mechanosensory behavior (GO:0007638)2.70263054
100detection of calcium ion (GO:0005513)2.69410158
101dendrite development (GO:0016358)2.69222902
102calcium-mediated signaling using intracellular calcium source (GO:0035584)2.66520298
103cellular potassium ion homeostasis (GO:0030007)2.66387463
104potassium ion homeostasis (GO:0055075)2.66326475
105adult walking behavior (GO:0007628)2.64794424
106positive regulation of dendritic spine morphogenesis (GO:0061003)2.64114782
107regulation of neurotransmitter levels (GO:0001505)2.63888236
108membrane hyperpolarization (GO:0060081)2.63434961
109intraspecies interaction between organisms (GO:0051703)2.62559914
110social behavior (GO:0035176)2.62559914
111G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.60035290
112regulation of respiratory gaseous exchange (GO:0043576)2.59654136
113regulation of cAMP-dependent protein kinase activity (GO:2000479)2.58404176
114negative regulation of cytosolic calcium ion concentration (GO:0051481)2.58170959
115regulation of calcium ion-dependent exocytosis (GO:0017158)2.56694526
116regulation of neurotransmitter transport (GO:0051588)2.55939737
117membrane depolarization during action potential (GO:0086010)2.53607623
118regulation of female receptivity (GO:0045924)2.52791167
119nucleus localization (GO:0051647)2.50117598
120negative regulation of dendrite development (GO:2000171)2.48027656
121negative regulation of exocytosis (GO:0045920)2.47529301
122negative regulation of dendrite morphogenesis (GO:0050774)2.46413250
123axon ensheathment in central nervous system (GO:0032291)2.45934102
124central nervous system myelination (GO:0022010)2.45934102
125female mating behavior (GO:0060180)2.44007804
126heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.44003725
127regulation of exocytosis (GO:0017157)2.43330129
128potassium ion import (GO:0010107)2.42417394
129serotonin metabolic process (GO:0042428)2.42234763
130relaxation of smooth muscle (GO:0044557)2.41250815
131L-amino acid import (GO:0043092)2.39618537
132regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.39122730
133membrane assembly (GO:0071709)2.38525442
134dopamine biosynthetic process (GO:0042416)2.36839987
135definitive hemopoiesis (GO:0060216)2.36516373
136establishment of nucleus localization (GO:0040023)2.31502830
137apical protein localization (GO:0045176)2.31459408
138positive regulation of meiosis (GO:0045836)2.27975349
139neuronal action potential (GO:0019228)2.25938716
140positive regulation of potassium ion transmembrane transport (GO:1901381)2.25442195
141sodium ion export (GO:0071436)2.22510368
142regulation of Rap GTPase activity (GO:0032317)2.22224212

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.62721125
2GBX2_23144817_ChIP-Seq_PC3_Human3.78503788
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.00360399
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98821853
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.94608361
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60184202
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56257554
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56257554
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.53016362
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51924223
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48298637
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45798716
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.36522733
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32537378
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.25817178
16TAF15_26573619_Chip-Seq_HEK293_Human2.24310761
17REST_21632747_ChIP-Seq_MESCs_Mouse2.23346209
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07518663
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.05328668
20AR_21572438_ChIP-Seq_LNCaP_Human2.05318969
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.04573506
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03064769
23* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01147841
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00127091
25* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93000493
26DROSHA_22980978_ChIP-Seq_HELA_Human1.84445638
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81020946
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81005978
29P300_19829295_ChIP-Seq_ESCs_Human1.74508076
30* SMAD4_21799915_ChIP-Seq_A2780_Human1.73871591
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.72245030
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69728065
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.67358435
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.63196069
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.62290053
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61458750
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61244473
38VDR_22108803_ChIP-Seq_LS180_Human1.59943997
39* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59280972
40* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59041614
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58668516
42ZNF274_21170338_ChIP-Seq_K562_Hela1.55939651
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55871369
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.54529681
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.51796689
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51241278
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51188141
48* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51075430
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49781093
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49054576
51IGF1R_20145208_ChIP-Seq_DFB_Human1.46718394
52* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.45578043
53* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45060788
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44964032
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41748064
56* FUS_26573619_Chip-Seq_HEK293_Human1.36103305
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35590269
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35590269
59AR_25329375_ChIP-Seq_VCAP_Human1.32676459
60RNF2_27304074_Chip-Seq_NSC_Mouse1.30202310
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.29288429
62FLI1_21867929_ChIP-Seq_TH2_Mouse1.27274486
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.27114138
64* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25883445
65EWS_26573619_Chip-Seq_HEK293_Human1.25630828
66* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25593637
67* SOX2_21211035_ChIP-Seq_LN229_Gbm1.25025004
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24057241
69* STAT3_23295773_ChIP-Seq_U87_Human1.22867512
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.22191792
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20780169
72TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19127557
73P53_22387025_ChIP-Seq_ESCs_Mouse1.18400122
74AHR_22903824_ChIP-Seq_MCF-7_Human1.17748948
75TP53_18474530_ChIP-ChIP_U2OS_Human1.17713095
76RING1B_27294783_Chip-Seq_ESCs_Mouse1.17671825
77TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.17548250
78ER_23166858_ChIP-Seq_MCF-7_Human1.17113528
79ERG_21242973_ChIP-ChIP_JURKAT_Human1.14537218
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.14438638
81* RUNX2_22187159_ChIP-Seq_PCA_Human1.13682316
82KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13672785
83* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13043271
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.10102417
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10030456
86RING1B_27294783_Chip-Seq_NPCs_Mouse1.09859828
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08681926
88TCF4_23295773_ChIP-Seq_U87_Human1.08062011
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07981561
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07981561
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07794032
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.07549208
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.07491132
94CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06945033
95* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06576506
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06204518
97BCAT_22108803_ChIP-Seq_LS180_Human1.05534598
98FLI1_27457419_Chip-Seq_LIVER_Mouse1.05400345
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05299532
100* TP53_16413492_ChIP-PET_HCT116_Human1.04380288
101JUN_21703547_ChIP-Seq_K562_Human1.04144215
102MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03939245
103* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03433762
104YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02799247
105AR_19668381_ChIP-Seq_PC3_Human1.02570129
106* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02473072
107P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01816263
108FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01768734
109MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01625425
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95350047
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94523592
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93393023
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91945213
114* KDM2B_26808549_Chip-Seq_REH_Human0.91691711
115STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91270417
116E2F1_18555785_Chip-Seq_ESCs_Mouse0.91036460
117ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90821957
118SMAD3_21741376_ChIP-Seq_ESCs_Human0.90642834
119EP300_21415370_ChIP-Seq_HL-1_Mouse0.90601120

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.30198160
2MP0004859_abnormal_synaptic_plasticity5.12679517
3MP0004270_analgesia3.92051386
4* MP0003635_abnormal_synaptic_transmissio3.65335756
5MP0001968_abnormal_touch/_nociception3.23040316
6MP0009745_abnormal_behavioral_response3.10123738
7MP0002063_abnormal_learning/memory/cond3.05647023
8MP0002735_abnormal_chemical_nociception2.87607290
9MP0002064_seizures2.87403676
10MP0002734_abnormal_mechanical_nocicepti2.80604420
11MP0002572_abnormal_emotion/affect_behav2.73058226
12MP0002736_abnormal_nociception_after2.72406171
13MP0009046_muscle_twitch2.60148376
14MP0006276_abnormal_autonomic_nervous2.53557145
15MP0005423_abnormal_somatic_nervous2.51403796
16* MP0002272_abnormal_nervous_system2.45672240
17MP0000778_abnormal_nervous_system2.44043295
18MP0001486_abnormal_startle_reflex2.39445036
19MP0001440_abnormal_grooming_behavior2.32256369
20MP0002733_abnormal_thermal_nociception2.28650096
21MP0001970_abnormal_pain_threshold2.15022781
22MP0001501_abnormal_sleep_pattern2.12559482
23MP0002067_abnormal_sensory_capabilities2.03646246
24* MP0002184_abnormal_innervation1.99118003
25MP0001529_abnormal_vocalization1.90665445
26MP0003329_amyloid_beta_deposits1.87943168
27MP0003724_increased_susceptibility_to1.81915211
28MP0001905_abnormal_dopamine_level1.76943733
29MP0009780_abnormal_chondrocyte_physiolo1.75106804
30MP0002557_abnormal_social/conspecific_i1.72618036
31MP0005386_behavior/neurological_phenoty1.70587074
32MP0004924_abnormal_behavior1.70587074
33MP0004858_abnormal_nervous_system1.65276146
34MP0002822_catalepsy1.64836831
35MP0000955_abnormal_spinal_cord1.58960462
36MP0004811_abnormal_neuron_physiology1.54986951
37MP0002882_abnormal_neuron_morphology1.48710927
38MP0005187_abnormal_penis_morphology1.45956173
39MP0001984_abnormal_olfaction1.45276791
40MP0005645_abnormal_hypothalamus_physiol1.45009812
41MP0004742_abnormal_vestibular_system1.43922850
42MP0003183_abnormal_peptide_metabolism1.42350384
43MP0008569_lethality_at_weaning1.37356883
44* MP0002066_abnormal_motor_capabilities/c1.36258852
45MP0010386_abnormal_urinary_bladder1.31633914
46MP0004885_abnormal_endolymph1.31553457
47MP0002837_dystrophic_cardiac_calcinosis1.30363157
48MP0002909_abnormal_adrenal_gland1.30187732
49MP0001851_eye_inflammation1.27785847
50MP0001502_abnormal_circadian_rhythm1.27569178
51MP0000920_abnormal_myelination1.25845033
52MP0003122_maternal_imprinting1.25739852
53MP0005646_abnormal_pituitary_gland1.24898536
54MP0004142_abnormal_muscle_tone1.18273061
55MP0008877_abnormal_DNA_methylation1.16416200
56MP0003633_abnormal_nervous_system1.15955434
57MP0003787_abnormal_imprinting1.14193181
58MP0003890_abnormal_embryonic-extraembry1.13808588
59MP0003634_abnormal_glial_cell1.13209233
60MP0000383_abnormal_hair_follicle1.12148749
61MP0002152_abnormal_brain_morphology1.12027260
62MP0010368_abnormal_lymphatic_system1.11419768
63MP0003631_nervous_system_phenotype1.07392400
64MP0004130_abnormal_muscle_cell1.06799412
65MP0004145_abnormal_muscle_electrophysio1.03731182
66MP0003283_abnormal_digestive_organ1.03464692
67MP0004883_abnormal_blood_vessel1.01906743
68MP0005171_absent_coat_pigmentation1.01698269
69MP0003879_abnormal_hair_cell1.01048390
70MP0002229_neurodegeneration1.00284435
71MP0005248_abnormal_Harderian_gland0.97822867
72MP0010678_abnormal_skin_adnexa0.96429158
73MP0005551_abnormal_eye_electrophysiolog0.96318701
74MP0001963_abnormal_hearing_physiology0.95753430
75MP0002752_abnormal_somatic_nervous0.95712050
76MP0000465_gastrointestinal_hemorrhage0.94170600
77MP0003121_genomic_imprinting0.93743499
78MP0000631_abnormal_neuroendocrine_gland0.92978508
79MP0002009_preneoplasia0.92139650
80MP0005084_abnormal_gallbladder_morpholo0.90595829
81MP0002928_abnormal_bile_duct0.90239549
82MP0000604_amyloidosis0.90174409
83* MP0005464_abnormal_platelet_physiology0.89721319
84MP0004043_abnormal_pH_regulation0.89669001
85MP0003632_abnormal_nervous_system0.89144513
86MP0003828_pulmonary_edema0.88943878
87MP0005595_abnormal_vascular_smooth0.87815287
88MP0000751_myopathy0.87430290
89MP0002069_abnormal_eating/drinking_beha0.85543169
90MP0003690_abnormal_glial_cell0.85399363
91MP0004133_heterotaxia0.83202863
92MP0002876_abnormal_thyroid_physiology0.83179873
93MP0000569_abnormal_digit_pigmentation0.82524334
94MP0005388_respiratory_system_phenotype0.82520293
95MP0002133_abnormal_respiratory_system0.82520293
96MP0004484_altered_response_of0.81914225
97MP0004085_abnormal_heartbeat0.81436579
98MP0001485_abnormal_pinna_reflex0.81304979
99MP0005167_abnormal_blood-brain_barrier0.80304029
100* MP0001188_hyperpigmentation0.79097365
101MP0005535_abnormal_body_temperature0.78907197
102MP0001177_atelectasis0.78645574
103MP0002638_abnormal_pupillary_reflex0.78147882
104MP0000013_abnormal_adipose_tissue0.77004820
105MP0001299_abnormal_eye_distance/0.76934590
106MP0000026_abnormal_inner_ear0.75470120
107MP0008004_abnormal_stomach_pH0.74797843
108MP0002751_abnormal_autonomic_nervous0.74655945
109MP0006072_abnormal_retinal_apoptosis0.73880972
110MP0000230_abnormal_systemic_arterial0.73850279
111MP0005394_taste/olfaction_phenotype0.73418361
112MP0005499_abnormal_olfactory_system0.73418361
113MP0008057_abnormal_DNA_replication0.72248456
114MP0003638_abnormal_response/metabolism_0.72165537
115MP0004134_abnormal_chest_morphology0.71720102
116MP0003861_abnormal_nervous_system0.66866239
117MP0002090_abnormal_vision0.66713670
118MP0008874_decreased_physiological_sensi0.66290660
119MP0003303_peritoneal_inflammation0.64722256
120MP0001943_abnormal_respiration0.64706661
121MP0002160_abnormal_reproductive_system0.64705582
122MP0005623_abnormal_meninges_morphology0.64522799
123MP0001879_abnormal_lymphatic_vessel0.63807504
124MP0003938_abnormal_ear_development0.63175211
125MP0001664_abnormal_digestion0.62013916
126MP0005379_endocrine/exocrine_gland_phen0.58737601
127MP0002102_abnormal_ear_morphology0.57902804
128MP0008872_abnormal_physiological_respon0.57698638
129MP0003136_yellow_coat_color0.54357809
130MP0001986_abnormal_taste_sensitivity0.53001056
131MP0000538_abnormal_urinary_bladder0.51812605
132MP0003137_abnormal_impulse_conducting0.51538429
133MP0004215_abnormal_myocardial_fiber0.51139937
134MP0005195_abnormal_posterior_eye0.50056765

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.72674023
2Myokymia (HP:0002411)5.25612236
3Focal seizures (HP:0007359)5.09159126
4Atonic seizures (HP:0010819)4.51884689
5Visual hallucinations (HP:0002367)4.39406256
6Papillary thyroid carcinoma (HP:0002895)4.38700781
7Epileptic encephalopathy (HP:0200134)4.29433401
8Hyperventilation (HP:0002883)3.91939185
9Progressive cerebellar ataxia (HP:0002073)3.89723464
10Febrile seizures (HP:0002373)3.88805470
11Neurofibrillary tangles (HP:0002185)3.85995083
12Cerebral inclusion bodies (HP:0100314)3.81944586
13Absence seizures (HP:0002121)3.79580428
14Metaphyseal dysplasia (HP:0100255)3.66457134
15Supranuclear gaze palsy (HP:0000605)3.66359847
16Dialeptic seizures (HP:0011146)3.59958936
17Action tremor (HP:0002345)3.58423262
18Broad-based gait (HP:0002136)3.43279905
19Termporal pattern (HP:0011008)3.43267543
20Insidious onset (HP:0003587)3.43267543
21Generalized tonic-clonic seizures (HP:0002069)3.42729034
22Amblyopia (HP:0000646)3.38625032
23Abnormality of the corticospinal tract (HP:0002492)3.30075945
24Excessive salivation (HP:0003781)3.23531961
25Drooling (HP:0002307)3.23531961
26Limb dystonia (HP:0002451)3.09001816
27Degeneration of the lateral corticospinal tracts (HP:0002314)3.06268245
28Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.06268245
29Mutism (HP:0002300)3.04099402
30Thyroid carcinoma (HP:0002890)3.02339818
31Absent speech (HP:0001344)2.89685231
32Progressive inability to walk (HP:0002505)2.83640845
33Truncal ataxia (HP:0002078)2.72312574
34Dysmetria (HP:0001310)2.70630730
35Anxiety (HP:0000739)2.67440139
36Ankle clonus (HP:0011448)2.64299463
37Hemiparesis (HP:0001269)2.60211493
38Abnormal eating behavior (HP:0100738)2.53168499
39Prolonged bleeding time (HP:0003010)2.51473542
40Pheochromocytoma (HP:0002666)2.50384035
41Gaze-evoked nystagmus (HP:0000640)2.48197254
42Abnormality of binocular vision (HP:0011514)2.46949746
43Diplopia (HP:0000651)2.46949746
44Epileptiform EEG discharges (HP:0011182)2.46514792
45Dysdiadochokinesis (HP:0002075)2.45615841
46Urinary bladder sphincter dysfunction (HP:0002839)2.43131013
47Polyphagia (HP:0002591)2.40871405
48Spastic gait (HP:0002064)2.40141288
49Exotropia (HP:0000577)2.38011245
50Hemiplegia (HP:0002301)2.36796189
51Abnormality of salivation (HP:0100755)2.36777069
52Poor eye contact (HP:0000817)2.32370447
53EEG with generalized epileptiform discharges (HP:0011198)2.32027871
54Gait imbalance (HP:0002141)2.31936710
55Acute myeloid leukemia (HP:0004808)2.31389450
56Agitation (HP:0000713)2.29412753
57Ulnar claw (HP:0001178)2.29144971
58Impaired vibration sensation in the lower limbs (HP:0002166)2.25032978
59Retinal dysplasia (HP:0007973)2.24141357
60Depression (HP:0000716)2.19685024
61Urinary urgency (HP:0000012)2.18786381
62Inability to walk (HP:0002540)2.16765374
63Hypsarrhythmia (HP:0002521)2.15828207
64Neuroendocrine neoplasm (HP:0100634)2.14201595
65Inappropriate behavior (HP:0000719)2.12069587
66Blue irides (HP:0000635)2.11987231
67Impaired social interactions (HP:0000735)2.09948807
68Abnormal social behavior (HP:0012433)2.09948807
69Disinhibition (HP:0000734)2.09922246
70Scanning speech (HP:0002168)2.09343276
71Protruding tongue (HP:0010808)2.07729399
72Lower limb muscle weakness (HP:0007340)2.07436991
73Amyotrophic lateral sclerosis (HP:0007354)2.07316412
74Stereotypic behavior (HP:0000733)2.07091900
75Akinesia (HP:0002304)2.06326330
76Thickened helices (HP:0000391)2.05481227
77Genetic anticipation (HP:0003743)2.05357798
78Papilledema (HP:0001085)2.05147679
79Peripheral hypomyelination (HP:0007182)2.03686115
80Generalized myoclonic seizures (HP:0002123)2.02718203
81Widely spaced teeth (HP:0000687)2.02107865
82Hypoplasia of the brainstem (HP:0002365)2.02038703
83Aplasia/Hypoplasia of the brainstem (HP:0007362)2.02038703
84Intention tremor (HP:0002080)1.99956652
85Psychosis (HP:0000709)1.98908872
86Hypothermia (HP:0002045)1.98263859
87Fetal akinesia sequence (HP:0001989)1.95900672
88Hyperthyroidism (HP:0000836)1.94651908
89Dynein arm defect of respiratory motile cilia (HP:0012255)1.94464416
90Absent/shortened dynein arms (HP:0200106)1.94464416
91Megalencephaly (HP:0001355)1.91363082
92Neoplasm of the tracheobronchial system (HP:0100552)1.89889489
93Abnormality of the axillary hair (HP:0100134)1.87399422
94Abnormality of secondary sexual hair (HP:0009888)1.87399422
95Postural tremor (HP:0002174)1.86717694
96Genital tract atresia (HP:0001827)1.85977283
97Neuronal loss in central nervous system (HP:0002529)1.85877917
98Clumsiness (HP:0002312)1.84980178
99Ventricular fibrillation (HP:0001663)1.84916142
100Acute lymphatic leukemia (HP:0006721)1.84378575
101Rapidly progressive (HP:0003678)1.84374353
102Specific learning disability (HP:0001328)1.83192288
103Absent frontal sinuses (HP:0002688)1.83110317
104Vaginal atresia (HP:0000148)1.81536650
105Medial flaring of the eyebrow (HP:0010747)1.81327367
106Esotropia (HP:0000565)1.80037141
107Postural instability (HP:0002172)1.77539902
108Apathy (HP:0000741)1.77507816
109Stomach cancer (HP:0012126)1.77401940
110Aqueductal stenosis (HP:0002410)1.76986658
111Torticollis (HP:0000473)1.76523201
112Hypoventilation (HP:0002791)1.75908026
113Impaired vibratory sensation (HP:0002495)1.74376029
114Congenital primary aphakia (HP:0007707)1.74353773
115Abnormality of ocular smooth pursuit (HP:0000617)1.72543115
116Morphological abnormality of the pyramidal tract (HP:0002062)1.72228723
117Delusions (HP:0000746)1.70961979
118Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.70615248
119Osteomalacia (HP:0002749)1.69848102
120Abnormal EKG (HP:0003115)1.67671710
121Impaired smooth pursuit (HP:0007772)1.67029471
122Curly hair (HP:0002212)1.66911931
123Increased mean platelet volume (HP:0011877)1.65595334
124Volvulus (HP:0002580)1.63790167
125Failure to thrive in infancy (HP:0001531)1.62188263
126Abnormality of macular pigmentation (HP:0008002)1.60970067
127Abnormal platelet volume (HP:0011876)1.58011335
128Sleep apnea (HP:0010535)1.53202856
129Status epilepticus (HP:0002133)1.52316900
130Bradykinesia (HP:0002067)1.51991907
131Neoplasm of the heart (HP:0100544)1.51973878
132Dyskinesia (HP:0100660)1.51947265
133Clonus (HP:0002169)1.49152503
134Long nose (HP:0003189)1.48885821
135Neoplasm of the thyroid gland (HP:0100031)1.47556883
136Gingival bleeding (HP:0000225)1.46917589
137Spontaneous hematomas (HP:0007420)1.46320614

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.95132595
2EPHA43.94756069
3MARK13.77941450
4CASK3.29264977
5MAP3K42.63868279
6MAP3K92.62955177
7PNCK2.57526207
8RIPK42.56900374
9MINK12.42789641
10MAP2K72.33908688
11PINK12.32684720
12NTRK12.10807403
13MAP3K121.98966016
14PLK21.95178392
15NTRK21.92954103
16FRK1.84194848
17MAPK131.82708131
18SIK21.76950363
19GRK51.69822815
20PAK61.65751074
21DAPK21.63835047
22MAP2K41.61277137
23TNIK1.50839281
24KSR21.45872745
25CDK51.44003672
26TEC1.43483201
27TIE11.36977208
28FGR1.36956282
29STK391.31663638
30KSR11.31083730
31TAOK31.27764452
32UHMK11.27674913
33FES1.26782643
34BMPR21.25538353
35CAMK2A1.23483950
36GRK71.20523574
37CAMK2B1.17133241
38ACVR1B1.15526458
39ARAF1.13980267
40PRPF4B1.11175305
41PRKCG1.09403805
42OXSR11.09121762
43MAP3K21.06232330
44PHKG21.05822972
45PHKG11.05822972
46PTK2B1.05194223
47CSNK1G21.04761600
48BCR1.04197442
49YES11.01847825
50SGK30.99721211
51STK38L0.99499219
52NME10.97499423
53DYRK20.96118093
54PKN10.95028243
55SGK2230.93695019
56SGK4940.93695019
57PRKCE0.91323633
58PAK30.90029497
59EPHA30.88637334
60MKNK20.88519458
61CDK140.88188302
62DAPK10.86936680
63CAMKK20.85843126
64DYRK1A0.85274256
65FGFR30.83674580
66WNK40.82754091
67CAMKK10.81614114
68LATS20.81486316
69TYRO30.80413476
70CDK180.79181422
71CAMK1G0.78246973
72CDK150.76385999
73ERBB20.75882668
74DMPK0.75754655
75CAMK2D0.73680953
76CSNK1G30.71725092
77WNK30.69660238
78RET0.69233760
79CDK190.68059255
80FER0.67806522
81PRKG20.67232595
82MAP3K10.67005209
83PRKD30.66919809
84MARK20.66597425
85MAPKAPK50.66494234
86CDK11A0.65863140
87ROCK20.65550749
88STK30.64426162
89LATS10.62461154
90PIK3CA0.62334728
91SGK10.61955447
92PDGFRB0.59203648
93STK110.58732471
94BMPR1B0.58053572
95CSNK1A1L0.56455202
96ADRBK10.56161552
97MAP3K130.55951240
98PRKCZ0.55901252
99SGK20.55484251
100FGFR20.55225389
101MKNK10.54489893
102ERBB30.54119763
103WNK10.54023544
104KIT0.52548292
105FYN0.52062012
106CDK30.50046068
107RPS6KA30.49838010
108HIPK20.49790259
109HCK0.49647192
110MAP2K10.48873719
111CAMK2G0.48057724
112ADRBK20.47239215
113MUSK0.46694690
114TAF10.43491832
115TRPM70.43191171
116CAMK10.43101257
117MAP3K60.42887547
118MAPK120.42464729
119CSNK1G10.42325533
120LIMK10.41705348
121PRKCH0.40907024
122RAF10.40658115
123RPS6KA20.39962255
124PRKG10.39732268
125PRKACG0.39016069
126NLK0.38612806
127MAPK100.38492490
128PRKACA0.38370265
129STK240.37913329
130JAK20.37900959
131STK380.36446184
132SIK30.35550603
133AKT30.34885443

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.77755419
2Synaptic vesicle cycle_Homo sapiens_hsa047212.72508487
3* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.62979918
4GABAergic synapse_Homo sapiens_hsa047272.49598361
5* Glutamatergic synapse_Homo sapiens_hsa047242.48496764
6* Long-term potentiation_Homo sapiens_hsa047202.46267078
7Amphetamine addiction_Homo sapiens_hsa050312.36580833
8* Circadian entrainment_Homo sapiens_hsa047132.36070146
9Morphine addiction_Homo sapiens_hsa050322.30498217
10* Dopaminergic synapse_Homo sapiens_hsa047282.13402029
11Olfactory transduction_Homo sapiens_hsa047402.08834695
12* Serotonergic synapse_Homo sapiens_hsa047262.00809314
13Taste transduction_Homo sapiens_hsa047422.00631100
14* Salivary secretion_Homo sapiens_hsa049701.89999581
15Collecting duct acid secretion_Homo sapiens_hsa049661.86918242
16* Long-term depression_Homo sapiens_hsa047301.83515430
17* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.74443618
18* Renin secretion_Homo sapiens_hsa049241.73411255
19* Cholinergic synapse_Homo sapiens_hsa047251.72558670
20Axon guidance_Homo sapiens_hsa043601.69764733
21Cocaine addiction_Homo sapiens_hsa050301.69529727
22* Insulin secretion_Homo sapiens_hsa049111.62683299
23* Gastric acid secretion_Homo sapiens_hsa049711.54471213
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49904353
25* Oxytocin signaling pathway_Homo sapiens_hsa049211.47435491
26* Calcium signaling pathway_Homo sapiens_hsa040201.45310856
27* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.37739135
28Oxidative phosphorylation_Homo sapiens_hsa001901.35620202
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35399143
30* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34975688
31Vibrio cholerae infection_Homo sapiens_hsa051101.31690413
32* Gap junction_Homo sapiens_hsa045401.29299099
33* GnRH signaling pathway_Homo sapiens_hsa049121.28696272
34Alzheimers disease_Homo sapiens_hsa050101.25996333
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20705868
36Cardiac muscle contraction_Homo sapiens_hsa042601.18730396
37* Platelet activation_Homo sapiens_hsa046111.18671141
38* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16937076
39cAMP signaling pathway_Homo sapiens_hsa040241.12209625
40Phototransduction_Homo sapiens_hsa047441.09696016
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04742634
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02815392
43ErbB signaling pathway_Homo sapiens_hsa040121.02256517
44Glioma_Homo sapiens_hsa052140.98949892
45* Estrogen signaling pathway_Homo sapiens_hsa049150.98605798
46Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98371043
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97708145
48* Melanogenesis_Homo sapiens_hsa049160.96560617
49Nitrogen metabolism_Homo sapiens_hsa009100.96329246
50Type II diabetes mellitus_Homo sapiens_hsa049300.94782531
51Parkinsons disease_Homo sapiens_hsa050120.94600579
52* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91190291
53* Vascular smooth muscle contraction_Homo sapiens_hsa042700.90099677
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89225598
55Dorso-ventral axis formation_Homo sapiens_hsa043200.89141237
56* Pancreatic secretion_Homo sapiens_hsa049720.82148160
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81405197
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.79339348
59Prolactin signaling pathway_Homo sapiens_hsa049170.78341063
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77656296
61Choline metabolism in cancer_Homo sapiens_hsa052310.77480108
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75756267
63Ras signaling pathway_Homo sapiens_hsa040140.72601652
64MAPK signaling pathway_Homo sapiens_hsa040100.71492728
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71482954
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67274168
67VEGF signaling pathway_Homo sapiens_hsa043700.67136960
68Dilated cardiomyopathy_Homo sapiens_hsa054140.66978470
69Bile secretion_Homo sapiens_hsa049760.64241182
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64174023
71Fatty acid biosynthesis_Homo sapiens_hsa000610.64116810
72Renal cell carcinoma_Homo sapiens_hsa052110.62897536
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62683626
74* Sphingolipid signaling pathway_Homo sapiens_hsa040710.62008380
75Rheumatoid arthritis_Homo sapiens_hsa053230.61877029
76Phagosome_Homo sapiens_hsa041450.59828047
77Oocyte meiosis_Homo sapiens_hsa041140.58895772
78Circadian rhythm_Homo sapiens_hsa047100.58259296
79Huntingtons disease_Homo sapiens_hsa050160.57547520
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55848880
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55848622
82Prion diseases_Homo sapiens_hsa050200.55431059
83mTOR signaling pathway_Homo sapiens_hsa041500.53952493
84* Rap1 signaling pathway_Homo sapiens_hsa040150.53870229
85Wnt signaling pathway_Homo sapiens_hsa043100.53828570
86Endometrial cancer_Homo sapiens_hsa052130.52375900
87Ether lipid metabolism_Homo sapiens_hsa005650.52340802
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.51937368
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.51818595
90* Thyroid hormone synthesis_Homo sapiens_hsa049180.50720298
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.50143757
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49696891
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49676278
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49324993
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48473683
96Histidine metabolism_Homo sapiens_hsa003400.48259128
97FoxO signaling pathway_Homo sapiens_hsa040680.47677068
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46536319
99Regulation of autophagy_Homo sapiens_hsa041400.46004110
100Focal adhesion_Homo sapiens_hsa045100.45152747
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.43164167
102Alcoholism_Homo sapiens_hsa050340.43031936
103Non-small cell lung cancer_Homo sapiens_hsa052230.42921400
104Ovarian steroidogenesis_Homo sapiens_hsa049130.42903088
105Endocytosis_Homo sapiens_hsa041440.42165989
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42115088
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42077883
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42045017
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41846857
110Osteoclast differentiation_Homo sapiens_hsa043800.41063090
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40985856
112* Amoebiasis_Homo sapiens_hsa051460.40922301
113Type I diabetes mellitus_Homo sapiens_hsa049400.39744353
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37395551
115Mineral absorption_Homo sapiens_hsa049780.37286150
116Inositol phosphate metabolism_Homo sapiens_hsa005620.36538352
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36250780
118Butanoate metabolism_Homo sapiens_hsa006500.36246079
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33743015
120* African trypanosomiasis_Homo sapiens_hsa051430.33144677
121Hedgehog signaling pathway_Homo sapiens_hsa043400.33073914
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32886098
123Melanoma_Homo sapiens_hsa052180.32366543
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31370338
125Chemokine signaling pathway_Homo sapiens_hsa040620.31221851

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